GNF-Pf-1034
  Mrv1591402191617072D          

 45 51  0  0  0  0            999 V2000
    0.7611    0.7458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5164    0.3983    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9041   -0.3888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7045   -0.5677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4774   -0.1249    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3361   -0.3664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6723   -0.7826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9768   -0.0978    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9653    0.7547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6027   -1.5682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8757   -1.9885    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2205   -1.4954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2199   -2.0211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8746   -1.6062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0786   -0.8294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9551   -0.7935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8252   -0.9780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3107   -1.7239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1018   -1.9580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3662   -2.7286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8238   -3.3297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1711   -4.0825    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0157   -3.2147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3299   -3.7481    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5525   -4.1222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0249   -4.7579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2148   -4.6516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8483   -3.9043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1052   -3.4442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4752   -2.8312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8520   -3.3473    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7045   -4.1706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0838   -3.1110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9046   -2.3244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4769   -1.7457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3017   -0.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2503   -2.0088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7841   -1.3906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3871   -3.3093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1867   -3.4058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8520   -2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3387   -1.4780    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2628   -1.1719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0019   -2.1936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2382   -2.2838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  6 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
  3 36  4  0  0  0  0
 35 37  4  0  0  0  0
 30 37  1  0  0  0  0
 37 38  4  0  0  0  0
  4 38  4  0  0  0  0
 28 39  4  0  0  0  0
 39 40  4  0  0  0  0
 25 40  4  0  0  0  0
 23 41  4  0  0  0  0
 18 41  4  0  0  0  0
 16 42  1  0  0  0  0
 42 43  1  0  0  0  0
 42 44  1  0  0  0  0
 44 45  1  0  0  0  0
 14 45  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1034

>  <JC_XSMILES>
COC1=C2OC3=C(OC)C(OC)=CC4=C3C(CC5=CC=C(O)C(OC6=CC=C(CC7N(C)CCC(=C1)C7=C2)C=C6)=C5)N(C)CC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.997

>  <W2 Pf proliferation inhibition EC50 uM>
1.061

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-104
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
  8 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-104

>  <JC_XSMILES>
NC1=NC(N)=C2C=C(C=CC2=N1)S(=O)(=O)N3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02017

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.674

>  <Powder data?>
No

>  <IFI value>
0.1640625

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1042
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6548   -1.4365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8683   -2.2334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0714   -2.4469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 17 23  4  0  0  0  0
 13 24  4  0  0  0  0
 24 25  4  0  0  0  0
  5 25  4  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 26 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1042

>  <JC_XSMILES>
COC1=CC2=C(C=C1OC)C(=O)N(NC(=O)C3=CC=CC(F)=C3)C(=N2)C4CCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.055

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.083333333

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1046
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    1.4630    1.3575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9933    0.7255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7111   -0.0498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2414   -0.6817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2414   -2.3317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5269   -1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5269   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7717   -0.0498    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5842   -0.1930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1145    0.4390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9269    0.2957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2091   -0.4795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6788   -1.1115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8663   -0.9683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  4 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1046

>  <JC_XSMILES>
C=CCC1(CCCCC1)NC2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.052

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1179
  Mrv1591402191617072D          

 41 46  0  0  0  0            999 V2000
    2.7742   -4.3934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0205   -4.0577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3530   -4.5425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5994   -4.2068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5133   -3.3863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1808   -2.9015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0947   -2.0810    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7622   -1.5962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5159   -1.9319    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6761   -0.7757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9425   -0.3794    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2061   -0.7512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1598   -1.5749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5767   -1.9467    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6229   -2.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3594   -3.1421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0496   -2.6902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0034   -1.8665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2669   -1.4947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2206   -0.6710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0587    0.4422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4804    1.0305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8848    0.5445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4769    1.1059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1123    0.5831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8557   -0.3607    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3049   -0.2413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3423   -0.5696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7981    0.1788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4479    1.9304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1474    2.3677    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7194    2.3176    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6904    3.1420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9619    3.5292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9329    4.3537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6325    4.7910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3610    4.4039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0605    4.8412    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.3900    3.5794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9344   -3.2372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6020   -2.7524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 10 27  1  0  0  0  0
 23 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 25 29  1  0  0  0  0
 24 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  1  0  0  0  0
 37 39  4  0  0  0  0
 33 39  4  0  0  0  0
  6 40  1  0  0  0  0
  2 40  1  0  0  0  0
 40 41  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1179

>  <JC_XSMILES>
CC1CCCC(NC(=O)C2N(CCN3CCCCC3C)C(=O)C4C(C5OC24C=C5)C(=O)NC6=CC=CC(Cl)=C6)C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
>10.36

>  <W2 Pf proliferation inhibition EC50 uM>
4.61

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
47.72

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1251
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
  7 21  4  0  0  0  0
  5 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1251

>  <JC_XSMILES>
OC1=CC=C(NC2=NC(N3CCCC3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.584

>  <W2 Pf proliferation inhibition EC50 uM>
0.926

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.045454545

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1325
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2337    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    3.0624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -0.5422    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -0.1006    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 11 19  4  0  0  0  0
  7 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1325

>  <JC_XSMILES>
CC(C)N1CCC2=C(C1)SC(NC(=O)C(C)(C)C)=C2C(N)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.035

>  <W2 Pf proliferation inhibition EC50 uM>
6.26

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
71.21

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1458
  Mrv1591402191617072D          

 21 25  0  0  0  0            999 V2000
    5.1116   -1.8201    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9401   -2.6271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1864   -2.9626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4327   -2.6271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7653   -3.1120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8515   -3.9325    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6052   -4.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2726   -3.7831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0796   -3.9546    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.4921   -4.6691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3171   -4.6691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7296   -3.9546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3171   -3.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8691   -2.6271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6228   -2.9626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3765   -2.6271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0439   -3.1120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9577   -3.9325    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2040   -4.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5366   -3.7831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4921   -3.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 15 20  4  0  0  0  0
 13 21  4  0  0  0  0
  2 21  1  0  0  0  0
  9 21  4  0  0  0  0
M  CHG  1   9   1
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1458

>  <JC_XSMILES>
O=C1C2=CC=CC=C2[N+]3=CC=C4C(NC5=CC=CC=C45)=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0749

>  <W2 Pf proliferation inhibition EC50 uM>
0.0464

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.589

>  <Powder data?>
Yes

>  <IFI value>
0.412162162

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-147
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    7.3697   -2.3781    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.0841   -2.7906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7986   -2.3781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5131   -2.7906    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.2275   -2.3781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9420   -2.7906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6565   -2.3781    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.3710   -2.7906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0854   -2.3781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0854   -1.5531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.7999   -1.1406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.5144   -1.5531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2990   -1.2982    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.7839   -1.9656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.6044   -2.0518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.9400   -2.8055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4550   -3.4730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.6345   -3.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2990   -2.6330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.5144   -2.3781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.7999   -2.7906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 20 21  4  0  0  0  0
  9 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  13
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-147

>  <JC_XSMILES>
OCCNCCNCC1=CC=C2NC3=CC=CC=C3C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2913

>  <W2 Pf proliferation inhibition EC50 uM>
7.6

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
28.94

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1678
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 10 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
  8 24  4  0  0  0  0
  6 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1678

>  <JC_XSMILES>
CC1=CC=CC(NC2=NC(NCC3=CC=CO3)=C4C=CC=CC4=N2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2656

>  <W2 Pf proliferation inhibition EC50 uM>
0.326

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.93

>  <Powder data?>
Yes

>  <IFI value>
0.094339623

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1791
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 17 27  4  0  0  0  0
 27 28  4  0  0  0  0
 14 28  4  0  0  0  0
 12 29  4  0  0  0  0
  7 29  4  0  0  0  0
 29 30  4  0  0  0  0
  4 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1791

>  <JC_XSMILES>
CCOC1=CC=C2N=C(C)C=C(NC3=CC=C(OCC4=CC=CC=C4Cl)C=C3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.142

>  <W2 Pf proliferation inhibition EC50 uM>
0.357

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.84

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1864
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    8.5737    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    6.6000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    5.8855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    7.3145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 22 27  4  0  0  0  0
  4 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
  2 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1864

>  <JC_XSMILES>
NC1=NC(NCC2CCC(CC2)CNS(=O)(=O)C3=CC=CC4=CC=CC=C34)=NC5=CC=CC=C15

>  <PF proliferation inhibition 3D7 EC50 uM>
0.684

>  <W2 Pf proliferation inhibition EC50 uM>
0.571

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.0390625

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2054
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
 16 22  4  0  0  0  0
  7 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2054

>  <JC_XSMILES>
CN(C)C1=CC=C(NC2=C3CCCC3=NC4=CC=C(C)C=C24)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.791

>  <W2 Pf proliferation inhibition EC50 uM>
0.95

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.79

>  <Powder data?>
Yes

>  <IFI value>
0.010638298

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2156
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
    2.0652   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4521   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  3  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
  9 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2156

>  <JC_XSMILES>
CCN1C=CN=C1CC2COC3=CC=CC=C3O2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.044

>  <W2 Pf proliferation inhibition EC50 uM>
0.443

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.011764706

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2170
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  5 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2170

>  <JC_XSMILES>
OCCNC1=NC(NC2=CC=C(Cl)C=C2)=NC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.321

>  <W2 Pf proliferation inhibition EC50 uM>
0.508

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.56

>  <Powder data?>
Yes

>  <IFI value>
0.014705882

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2277
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 12 23  4  0  0  0  0
  7 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2277

>  <JC_XSMILES>
CCOC1=CC=C2N=C(C)C=C(NC3=CC=C(C=C3)N(C)C)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.344

>  <W2 Pf proliferation inhibition EC50 uM>
0.662

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.65

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2303
  Mrv1591402191617072D          

 25 29  0  0  1  0            999 V2000
    3.2789   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.8500   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3509   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1340    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3509    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1794    1.8869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7925    2.4389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5771    2.1840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  4  3  1  0  0  0  0
  4  5  1  6  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 15 14  1  0  0  0  0
 15  2  1  6  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 14 24  1  0  0  0  0
 24 25  4  0  0  0  0
 17 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2303

>  <JC_XSMILES>
CN1C[C@@H](CSC2=CC=CC=N2)C=C3[C@H]1CC4=CNC5=CC=CC3=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2257

>  <W2 Pf proliferation inhibition EC50 uM>
0.393

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.048780488

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2356
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 11 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
  9 25  4  0  0  0  0
  7 26  4  0  0  0  0
  3 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2356

>  <JC_XSMILES>
COC1=CC=CC(NC2=NC(NCC3CCCO3)=C4C=CC=CC4=N2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2303

>  <W2 Pf proliferation inhibition EC50 uM>
0.2859

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.67

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2363
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
   -0.1712    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9011    4.3735    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2337    4.8584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5663    4.3735    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9962   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  2  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
  4 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  3  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
 21 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2363

>  <JC_XSMILES>
CC1=CC(C=C(C)N1C2=CC=C3OCOC3=C2)=C(C#N)C4=NC5=CC=CC=C5S4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.038

>  <W2 Pf proliferation inhibition EC50 uM>
3.71

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2377
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  2 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 14 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2377

>  <JC_XSMILES>
OC(CCNC1CCCCC1)COC2=CC=CC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.789

>  <W2 Pf proliferation inhibition EC50 uM>
0.366

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2380
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    1.2448   -0.6055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1842   -0.6055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2380

>  <JC_XSMILES>
CC1(C)N=C(N)N=C(N)N1C2=CC=C(F)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02175

>  <W2 Pf proliferation inhibition EC50 uM>
1.859

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
51.02

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2523
  Mrv1591402191617072D          

 32 37  0  0  0  0            999 V2000
    3.6771   -1.7412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3969   -1.3381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0644   -0.8532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5493   -1.5206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0342   -0.8532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7017   -1.3381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5165   -1.2091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0357   -1.8502    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7400   -2.6204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9252   -2.7495    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2592   -3.2616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0741   -3.1325    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5933   -3.7737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2976   -4.5439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4828   -4.6729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9636   -4.0318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8122   -0.4389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2930    0.2023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5886    0.9725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4035    1.1015    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.9227    0.4604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7375    0.5895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2567   -0.0517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9610   -0.8219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1462   -0.9510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6270   -0.3098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2167   -2.0056    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9618   -2.7902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1368   -2.7902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8819   -2.0056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8369   -0.7323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0323   -0.9143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  7 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 17 26  4  0  0  0  0
 21 26  4  0  0  0  0
  6 27  1  0  0  0  0
  4 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
  2 30  1  0  0  0  0
  4 30  1  0  0  0  0
  2 31  1  0  0  0  0
 31 32  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2523

>  <JC_XSMILES>
CC1(CC23CC(C(OC(=O)C4=CC=CC=C4)C5=CC=NC6=CC=CC=C56)N2CCC13)C=C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1757

>  <W2 Pf proliferation inhibition EC50 uM>
0.938

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
29.2

>  <Powder data?>
Yes

>  <IFI value>
0.036363636

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2586
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
  9 26  4  0  0  0  0
  7 27  4  0  0  0  0
 27 28  4  0  0  0  0
  4 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2586

>  <JC_XSMILES>
CCOC1=CC=C(NC2=NC(NCC3=CC=CC=C3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0882

>  <W2 Pf proliferation inhibition EC50 uM>
0.17

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.67

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2592
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 14 28  4  0  0  0  0
  9 28  4  0  0  0  0
 28 29  4  0  0  0  0
  6 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2592

>  <JC_XSMILES>
CCOC(=O)C1=CC=C2N=C(C)C=C(NC3=CC=C(C=C3)N4CCCCC4)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2917

>  <W2 Pf proliferation inhibition EC50 uM>
0.634

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.19

>  <Powder data?>
Yes

>  <IFI value>
0.011235955

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2607
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    5.0013    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
  8 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 19 33  4  0  0  0  0
 27 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2607

>  <JC_XSMILES>
CCCCCCCN(CCCCCCC)CC(O)C1=CC2=CC=CC=C2C3=CC(Br)=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.867

>  <W2 Pf proliferation inhibition EC50 uM>
0.1365

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>4.63

>  <Powder data?>
No

>  <IFI value>
0.008849558

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2727
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
  6 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2727

>  <JC_XSMILES>
ClCC(=O)NC1=CC=C(CN2CCCCC2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.976

>  <W2 Pf proliferation inhibition EC50 uM>
0.911

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
34.07

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2760
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  8 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2760

>  <JC_XSMILES>
CN(C)CCCNC1=CC(C)=NC2=CC=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.716

>  <W2 Pf proliferation inhibition EC50 uM>
1.382

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
53.25

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
Hydrochloride

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2783
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    5.2224   -3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8099   -2.5559    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849   -2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7474   -3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3349   -2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5099   -2.5559    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0974   -1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2724   -1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1401   -1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9651   -1.1270    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.2724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0974   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5099   -1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3349   -1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7474   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849    0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8099    0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2224    1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474    1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4599    1.7309    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2224   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4599   -1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7474   -1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 19 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 15 26  4  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2783

>  <JC_XSMILES>
COC1=CC=C2N=C3C=C(Cl)C=CC3=C(NCCN(CCN)CCN)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.808

>  <W2 Pf proliferation inhibition EC50 uM>
0.2538

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.144578313

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2821
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
 18 19  4  0  0  0  0
 12 19  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
  8 26  4  0  0  0  0
  6 27  4  0  0  0  0
 27 28  4  0  0  0  0
  3 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2821

>  <JC_XSMILES>
COC1=CC=C(NC2=NC(NC3=CC=C(OC)C=C3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0573

>  <W2 Pf proliferation inhibition EC50 uM>
0.0519

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.104

>  <Powder data?>
No

>  <IFI value>
0.07518797

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2864
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    2.2428   -2.5916    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3963    2.4068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3963    3.2318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    3.4867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6658    2.8193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -5.9016    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  2  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
  7 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  4 20  4  0  0  0  0
 15 20  4  0  0  0  0
  2 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 21 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2864

>  <JC_XSMILES>
OC(CN1C(=N)N(CCN2CCCC2)C3=CC=CC=C13)C4=CC=C(Cl)C(Cl)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.083

>  <W2 Pf proliferation inhibition EC50 uM>
0.2566

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.9

>  <Powder data?>
Yes

>  <IFI value>
0.081967213

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2867
  Mrv1591402191617072D          

 59 65  0  0  1  0            999 V2000
    6.8104    0.9185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5282    0.1433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.9979   -0.7752    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.8592    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    3.3000    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    9.2881    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    3.3000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   10.7171    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   10.7171    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   11.4315    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  6  0  0  0
  3  4  1  1  0  0  0
  3  5  1  0  0  0  0
  6  5  1  0  0  0  0
  6  7  1  1  0  0  0
  8  7  1  6  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 11 10  1  0  0  0  0
 11 12  1  1  0  0  0
 13 12  1  6  0  0  0
 13 14  1  0  0  0  0
 15 14  1  0  0  0  0
 15 16  1  1  0  0  0
 17 15  1  0  0  0  0
 17 18  1  1  0  0  0
 19 18  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 24 22  1  0  0  0  0
 24 25  1  1  0  0  0
 24 26  1  0  0  0  0
 19 26  1  0  0  0  0
 17 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 13 29  1  0  0  0  0
 11 30  1  0  0  0  0
 30 31  1  1  0  0  0
 30 32  1  0  0  0  0
  8 32  1  0  0  0  0
 10 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
  6 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  1  0  0  0  0
 37 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 36 42  4  0  0  0  0
 43 42  1  0  0  0  0
  3 43  1  0  0  0  0
 43 44  1  6  0  0  0
 44 45  2  0  0  0  0
 44 46  1  0  0  0  0
 46 47  1  0  0  0  0
 40 48  1  0  0  0  0
 48 49  2  0  0  0  0
 48 50  1  0  0  0  0
 50 51  4  0  0  0  0
 51 52  1  0  0  0  0
 51 53  4  0  0  0  0
 53 54  4  0  0  0  0
 54 55  4  0  0  0  0
 55 56  1  0  0  0  0
 55 57  4  0  0  0  0
 50 57  4  0  0  0  0
 57 58  1  0  0  0  0
 39 58  1  0  0  0  0
 58 59  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2867

>  <JC_XSMILES>
CC[C@@]1(O)C[C@H](O[C@@H]2CC([C@@H](O[C@@H]3C[C@@H](O)[C@@H](O[C@@H]4CCC(=O)[C@@H](C)O4)C(C)O3)[C@@H](C)O2)N(C)C)C5=C(O)C6=C(C=C5[C@H]1C(=O)OC)C(=O)C7=C(O)C=CC(O)=C7C6=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0877

>  <W2 Pf proliferation inhibition EC50 uM>
0.0792

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.37

>  <Powder data?>
No

>  <IFI value>
0.214285714

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2883
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 12 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 10 26  4  0  0  0  0
  8 27  4  0  0  0  0
 27 28  4  0  0  0  0
  5 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2883

>  <JC_XSMILES>
COC(=O)C1=CC=C(NC2=NC(NCC3=CC=CO3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.279

>  <W2 Pf proliferation inhibition EC50 uM>
0.433

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.77

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2946
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -6.2621   -0.2092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5476   -0.6217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8331   -0.2092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1187   -0.6217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1187   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4042   -1.8592    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6897   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6897   -0.6217    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9753   -1.8592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2608   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5463   -1.8592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5463   -2.6842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1681   -3.0967    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8826   -2.6842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5971   -3.0967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3116   -2.6842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0260   -3.0967    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7077   -2.6319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4960   -2.8751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7974   -3.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3849   -4.3575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5691   -4.4805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9644   -3.9193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2608   -3.0967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9753   -2.6842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2608   -3.9217    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.9753   -4.3342    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.5463   -4.3342    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8331   -1.8592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5476   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2621   -1.8592    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 17 23  1  0  0  0  0
 12 24  4  0  0  0  0
 24 25  4  0  0  0  0
  9 25  4  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
  5 29  4  0  0  0  0
 29 30  4  0  0  0  0
  2 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  CHG  2  26   1  27  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2946

>  <JC_XSMILES>
CC1=CC=C(NC(=O)C2=CC=C(NCCCN3CCCCCC3)C(=C2)[N+]([O-])=O)C=C1F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0941

>  <W2 Pf proliferation inhibition EC50 uM>
0.371

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.94

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3081
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752    0.3126    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429    4.0641    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710    3.7211    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  2  0  0  0  0
  6  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 12 19  4  0  0  0  0
  8 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
  5 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3081

>  <JC_XSMILES>
CCCCN1C(=N)N(CC(O)C2=CC=C(Cl)C(Cl)=C2)C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0625

>  <W2 Pf proliferation inhibition EC50 uM>
0.1204

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.24

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3165
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    4.8171   -1.8430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7565   -1.8430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 14 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 11 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3165

>  <JC_XSMILES>
CC1(C)N=C(N)N=C(N)N1C2=CC=C(OC3=CC=C(Cl)C=C3)C(Cl)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.058

>  <W2 Pf proliferation inhibition EC50 uM>
0.628

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
35.09

>  <Powder data?>
Yes

>  <IFI value>
0.106382979

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3176
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
  9 15  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3176

>  <JC_XSMILES>
COC1=CC2=NC(NC3=CC=CC(F)=C3)=NC(N)=C2C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1478

>  <W2 Pf proliferation inhibition EC50 uM>
0.358

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.14

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3179
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8163   -1.7466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0416   -1.7466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
 14 15  1  0  0  0  0
  8 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3179

>  <JC_XSMILES>
CC1=CC=CC(=C1)N2C(N)=NC(N)=NC2(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02024

>  <W2 Pf proliferation inhibition EC50 uM>
0.0528

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.976

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3199
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    2.2428   -2.5916    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710    3.7211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -5.9016    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  2  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  4 21  4  0  0  0  0
 16 21  4  0  0  0  0
  2 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 22 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3199

>  <JC_XSMILES>
OC(CN1C(=N)N(CCN2CCCCC2)C3=CC=CC=C13)C4=CC=C(Cl)C(Cl)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0528

>  <W2 Pf proliferation inhibition EC50 uM>
0.2238

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.83

>  <Powder data?>
Yes

>  <IFI value>
0.095238095

>  <Salt>
Hydrochloride

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3206
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    1.5335    1.9562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5335    1.1312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7713    0.8155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4556    0.0533    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3694    0.0533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7819    0.7678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6069    0.7678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0194    1.4822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6069    2.1967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7819    2.1967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3694    1.4822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7713   -0.7089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5335   -1.0246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5335   -1.8496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2957   -0.7089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6114    0.0533    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4364    0.0533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8489   -0.6612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6739   -0.6612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0864   -1.3757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6739   -2.0901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8489   -2.0901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4364   -2.8046    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.4364   -1.3757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2957    0.8155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8029    0.0533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 18 24  4  0  0  0  0
 16 25  1  0  0  0  0
  2 25  1  0  0  0  0
 13 26  1  0  0  0  0
  2 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3206

>  <JC_XSMILES>
CC12CN(CC3=CC=CC=C3)CC(C)(CN(CC4=CC=CC(Br)=C4)C1)C2

>  <PF proliferation inhibition 3D7 EC50 uM>
3.62

>  <W2 Pf proliferation inhibition EC50 uM>
0.819

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
47.25

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3253
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  2  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 11 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3253

>  <JC_XSMILES>
CC(C)N(C(C)C)C(=O)CN1C=CC(=N)C2=CC=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
1.243

>  <W2 Pf proliferation inhibition EC50 uM>
1.654

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-330
  Mrv1591402191617072D          

 26 26  0  0  0  0            999 V2000
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894  -11.5500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473  -11.5500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907  -13.6125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-330

>  <JC_XSMILES>
CCCCCCCCCCCCOCCCNC(=O)C1=CC=CC(N)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.569

>  <W2 Pf proliferation inhibition EC50 uM>
>1.563

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019736842

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3301
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    5.0013   -1.2375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
 10  7  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3301

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)C=NN2CCN(CC2)CC3=CC=CC=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>7.22

>  <W2 Pf proliferation inhibition EC50 uM>
>1.588

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3461
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -6.9766   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2621   -1.8592    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5476   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5476   -0.6217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8331   -0.2092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1187   -0.6217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1187   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4042   -1.8592    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6897   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6897   -0.6217    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9753   -1.8592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2608   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5463   -1.8592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5463   -2.6842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1681   -3.0967    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8826   -2.6842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5971   -3.0967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3116   -2.6842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0260   -3.0967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7077   -2.6319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4960   -2.8751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7974   -3.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3849   -4.3575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5691   -4.4805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9644   -3.9193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2608   -3.0967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9753   -2.6842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2608   -3.9217    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.9753   -4.3342    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.5463   -4.3342    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8331   -1.8592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 19 25  1  0  0  0  0
 14 26  4  0  0  0  0
 26 27  4  0  0  0  0
 11 27  4  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  2  0  0  0  0
  7 31  4  0  0  0  0
  3 31  4  0  0  0  0
M  CHG  2  28   1  29  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3461

>  <JC_XSMILES>
COC1=CC=CC(NC(=O)C2=CC=C(NCCCC3CCCCCC3)C(=C2)[N+]([O-])=O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2259

>  <W2 Pf proliferation inhibition EC50 uM>
0.391

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
28.81

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3479
  Mrv1591402191617072D          

 31 32  0  0  0  0            999 V2000
   -0.0957  -10.6893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4444  -10.0657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2546  -10.2216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7946   -9.5980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5246   -8.8184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4444   -7.8829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6048   -9.7539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1449   -9.1302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9550   -9.2861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4951   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3052   -8.8184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8453   -8.1948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6555   -8.3507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9255   -9.1302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3854   -9.7539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5753   -9.5980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0352  -10.2216    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.2251  -10.0657    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.3052  -11.0012    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7356   -9.2861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2757   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.0057  -10.0657    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8158  -10.2216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3559   -9.5980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1660   -9.7539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4361  -10.5334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8960  -11.1571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1660  -11.9366    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.9762  -12.0925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0859  -11.0012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 15 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 24 31  4  0  0  0  0
M  CHG  2  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3479

>  <JC_XSMILES>
CCCN(CCC)CCCNC1=CC=C(C=C1[N+]([O-])=O)C(=O)NC2=CC=CC(OC)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1588

>  <W2 Pf proliferation inhibition EC50 uM>
0.32

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
24.01

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3485
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    2.9919    0.4949    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7063    0.0824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7063   -0.7426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9919   -1.1551    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9056   -1.9756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4577   -2.5887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2027   -3.3733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3957   -3.5448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8437   -2.9317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0986   -2.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6861   -1.4327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8792   -1.2611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6242   -0.4765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1763    0.1366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9832   -0.0349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2382   -0.8196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4208    0.4949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4208    1.3199    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.7063    1.7324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7063    2.5574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4208    2.9699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1353    2.5574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8497    2.9699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5642    2.5574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5642    1.7324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8497    1.3199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8497    0.4949    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1353    1.7324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  4 16  4  0  0  0  0
 11 16  4  0  0  0  0
  2 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 18 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  CHG  1  18   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3485

>  <JC_XSMILES>
OC(CN1C2=CC=CC=C2C3=CC=CC=C13)C[N+]4=CC=CC5=CC=CC(O)=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1988

>  <W2 Pf proliferation inhibition EC50 uM>
0.651

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
49.2

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3493
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  7 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  5 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3493

>  <JC_XSMILES>
OCCNC1=NC(NC2=CC=CC=C2)=NC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1666

>  <W2 Pf proliferation inhibition EC50 uM>
0.626

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
47.54

>  <Powder data?>
Yes

>  <IFI value>
0.014388489

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3594
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
  7 18  4  0  0  0  0
 12 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3594

>  <JC_XSMILES>
CN(C)CCNC1=CC(C)=NC2=CC=C(C)C=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.36

>  <W2 Pf proliferation inhibition EC50 uM>
0.709

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
59.13

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
Hydrochloride

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3618
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
  9 21  4  0  0  0  0
 14 21  4  0  0  0  0
  7 22  4  0  0  0  0
 22 23  4  0  0  0  0
  4 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3618

>  <JC_XSMILES>
CCOC1=CC=C(NC2=CC(C)=NC3=C(C)C=C(C)C=C23)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.484

>  <W2 Pf proliferation inhibition EC50 uM>
0.2251

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.23

>  <Powder data?>
Yes

>  <IFI value>
0.011111111

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3768
  Mrv1591402191617072D          

 18 21  0  0  1  0            999 V2000
    1.9663   -3.3428    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2485   -2.5675    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2485   -1.7425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9629   -1.3300    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6774   -1.7425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6774   -2.5675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9629   -2.9800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1004   -2.4300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1004   -1.8800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4360   -2.4243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8425   -2.9974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1141   -2.6100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6611   -2.8922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2931   -2.3619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1499   -1.5494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3746   -1.2673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2574   -1.7976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0743   -1.6828    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3768

>  <JC_XSMILES>
O[C@]1(CN2CCC1CC2)C3=CC4=CC=CC=C4S3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.177

>  <W2 Pf proliferation inhibition EC50 uM>
0.1014

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.016260163

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3823
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -0.1067   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078   -1.2991    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4888   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1019   -2.0811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8865   -1.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4996   -2.3782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3281   -3.1852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9411   -3.7372    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.5434   -3.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9303   -2.8881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 10 16  1  0  0  0  0
  9 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3823

>  <JC_XSMILES>
COC1=CC=CC=C1C(N2CCN(C)CC2)C3=NN=NN3CC4=CC=C(F)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
11.88

>  <W2 Pf proliferation inhibition EC50 uM>
0.97

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3839
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
   -0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
  7 22  4  0  0  0  0
 22 23  4  0  0  0  0
  4 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3839

>  <JC_XSMILES>
NC(=N)C1=CC=C(OCCCOC2=CC=C(C=C2)C(N)=N)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0755

>  <W2 Pf proliferation inhibition EC50 uM>
0.0595

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.25

>  <Powder data?>
No

>  <IFI value>
0.055555556

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4000
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4000

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C=CC(C)=CC2=C1NCCCN3CCOCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.9

>  <W2 Pf proliferation inhibition EC50 uM>
0.827

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047619048

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4012
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
  7 23  4  0  0  0  0
  5 24  4  0  0  0  0
 24 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4012

>  <JC_XSMILES>
FC1=CC=C(NC2=NC(NCC3=CC=CO3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.191

>  <W2 Pf proliferation inhibition EC50 uM>
0.1011

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.35

>  <Powder data?>
Yes

>  <IFI value>
0.096774194

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4076
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    4.0668    2.3479    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -0.5422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -0.3707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -0.9838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -1.7684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -1.9399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  6 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  5 16  4  0  0  0  0
 16 17  4  0  0  0  0
  2 17  4  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4076

>  <JC_XSMILES>
ClC1=CC=C2N(CC3=CC=CC=C3)C(=NC2=C1)N4CCNCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.049

>  <W2 Pf proliferation inhibition EC50 uM>
0.077

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4111
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  5 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4111

>  <JC_XSMILES>
OCCNC1=NC(NC2=CC=C(F)C=C2)=NC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.223

>  <W2 Pf proliferation inhibition EC50 uM>
0.749

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.029411765

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4202
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 13 19  4  0  0  0  0
 11 20  4  0  0  0  0
  6 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4202

>  <JC_XSMILES>
COC1=CC=C2N=C(C)C=C(NC3=CC=CC(O)=C3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2284

>  <W2 Pf proliferation inhibition EC50 uM>
0.347

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
51.03

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4223
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    4.5888   -0.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8263   -0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388    0.5230    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8263    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0638    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -0.1914    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3013    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5388    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9513    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7763    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.5388    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9513   -0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5388   -0.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138   -0.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3013   -0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  2  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 11 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4223

>  <JC_XSMILES>
CCCN(CCC)C(=O)CN1C=CC(=N)C2=CC=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
1.195

>  <W2 Pf proliferation inhibition EC50 uM>
0.671

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4240
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    2.2428   -2.5916    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -5.9016    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  2  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  7 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  4 20  4  0  0  0  0
 15 20  4  0  0  0  0
  2 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 21 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4240

>  <JC_XSMILES>
OC(CN1C(=N)N(CC2=CC=CC=C2)C3=CC=CC=C13)C4=CC=C(Cl)C(Cl)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.214

>  <W2 Pf proliferation inhibition EC50 uM>
0.0436

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.59

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4293
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -1.6889   -1.3402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9744   -1.7527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9744   -2.5777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2600   -2.9902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2600   -3.8152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9744   -4.2277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9744   -5.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2600   -5.4652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4545   -5.0527    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1690   -5.4652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9815   -5.6085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2636   -6.3837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0761   -6.5270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7333   -7.0157    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0155   -7.7909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9209   -6.8724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6387   -6.0972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1738   -5.9539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4512   -4.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2636   -4.5467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5458   -3.7714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3583   -3.6282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8886   -4.2602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6064   -5.0354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7939   -5.1787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6889   -3.8152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6889   -2.9902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4034   -2.5777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4034   -1.7527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 10 17  1  0  0  0  0
 17 18  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4293

>  <JC_XSMILES>
COC1=CC=C(CCNC2(CC(C)N(C)CC2C)CC3=CC=CC=C3)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.62

>  <W2 Pf proliferation inhibition EC50 uM>
0.2675

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
42.71

>  <Powder data?>
Yes

>  <IFI value>
0.054545455

>  <Salt>
Hydrochloride

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4298
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752    0.3126    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429    4.0641    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  2  0  0  0  0
  6  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
  8 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  5 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4298

>  <JC_XSMILES>
CCCCN1C(=N)N(CC(O)C2=CC=C(Br)C=C2)C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.466

>  <W2 Pf proliferation inhibition EC50 uM>
0.1406

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
22.51

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4303
  Mrv1591402191617072D          

 32 33  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 11 15  4  0  0  0  0
  7 15  4  0  0  0  0
 15 16  1  0  0  0  0
  9 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 19 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 25 32  4  0  0  0  0
 17 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4303

>  <JC_XSMILES>
CCN(CC)CC1=CC(=CC(CC=C)=C1O)C2=CC(CC=C)=C(O)C(CN(CC)CC)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2731

>  <W2 Pf proliferation inhibition EC50 uM>
0.0619

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.023529412

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4309
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    2.1581    0.0702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1581   -0.7548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4436   -1.1673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4436   -1.9923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1581   -2.4048    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8725   -1.9923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5870   -2.4048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5870   -3.2298    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8725   -3.6423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1581   -3.2298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3015   -3.6423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0159   -3.2298    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3015   -4.4673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9689   -4.9522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7140   -5.7368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8890   -5.7368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6340   -4.9522    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7291   -2.4048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6429   -3.2252    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1641   -3.3968    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5766   -2.6823    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0246   -2.0692    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1961   -1.2622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9807   -1.0073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1522   -0.2003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5391    0.3517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2455    0.0968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4170   -0.7102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
  4 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4309

>  <JC_XSMILES>
CCCC(N1CCN(CC1)C(=O)C2=CC=CO2)C3=NN=NN3C4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.333

>  <W2 Pf proliferation inhibition EC50 uM>
0.616

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4436
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    3.5439    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2584    1.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9728    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6873    1.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4018    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1162    1.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8307    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5452    1.1193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2989    1.4548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4704    2.2618    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.8509    0.8418    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.6714    0.9280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0069    1.6817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5220    2.3491    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.8274    1.7679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1630    2.5216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9834    2.6078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4684    1.9404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2889    2.0266    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.1328    1.1867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6177    0.5193    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   12.3123    1.1005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4384    0.1273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6933   -0.6573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1413   -1.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3343   -1.0989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0794   -0.3143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6314    0.2988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 15 22  4  0  0  0  0
 11 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
  8 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4436

>  <JC_XSMILES>
CCCCCCCN1C(=N)N(CC(O)C2=CC=C(Cl)C(Cl)=C2)C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2038

>  <W2 Pf proliferation inhibition EC50 uM>
0.0335

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.5

>  <Powder data?>
Yes

>  <IFI value>
0.092592593

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4500
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8520    0.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8520    0.6875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  9 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4500

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(CC2=CC=CC=C2)NC3CN4CCC3CC4

>  <PF proliferation inhibition 3D7 EC50 uM>
4.26

>  <W2 Pf proliferation inhibition EC50 uM>
0.3083

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>64.95

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
2

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4514
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    2.2428   -2.5916    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -5.9016    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  2  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  7 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  4 20  4  0  0  0  0
 15 20  4  0  0  0  0
  2 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4514

>  <JC_XSMILES>
OC(CN1C(=N)N(CC2=CC=CC=C2)C3=CC=CC=C13)C4=CC=C(Br)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2539

>  <W2 Pf proliferation inhibition EC50 uM>
0.1011

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.78

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4530
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  1  0  0  0  0
 13 18  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4530

>  <JC_XSMILES>
N=C1C=CN(CC(=O)N2CCCC3=CC=CC=C23)C4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
1.493

>  <W2 Pf proliferation inhibition EC50 uM>
0.453

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4548
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
  5 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  3 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4548

>  <JC_XSMILES>
COC1=CC2=NC(NC(N)=N)=NC(C)=C2C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02439

>  <W2 Pf proliferation inhibition EC50 uM>
0.0441

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.031496063

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4562
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
  6 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4562

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C=CC=CC2=C1NCCCN(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1981

>  <W2 Pf proliferation inhibition EC50 uM>
0.2222

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
52.12

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4586
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  6 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 15 19  1  0  0  0  0
  4 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4586

>  <JC_XSMILES>
C=CCC1CC(CC2=CC=CC=C2)=CC(CC=C)N1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.31

>  <W2 Pf proliferation inhibition EC50 uM>
0.1881

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
46.01

>  <Powder data?>
Yes

>  <IFI value>
0.039215686

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4608
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.2428   -2.5916    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -5.9016    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  2  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  7 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  4 16  4  0  0  0  0
 11 16  4  0  0  0  0
  2 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 17 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4608

>  <JC_XSMILES>
OC(CN1C(=N)N(CC=C)C2=CC=CC=C12)C3=CC=C(Cl)C(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1405

>  <W2 Pf proliferation inhibition EC50 uM>
0.0583

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.69

>  <Powder data?>
Yes

>  <IFI value>
0.095238095

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4685
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -0.4663   -0.8077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9966   -0.1757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8091   -0.3190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8091    0.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5269   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0572   -1.7262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3428   -2.1387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6283   -1.7262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0862   -2.1387    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8006   -1.7262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5151   -2.1387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2296   -1.7262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9441   -2.1387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9441   -2.9637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2296   -3.3762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5151   -2.9637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8006   -3.3762    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8697   -1.5830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1519   -0.8077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6216   -0.1757    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3394   -2.5015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8091   -3.1335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0913   -3.9087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9037   -4.0520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1859   -4.8272    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9984   -4.9705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4340   -3.4200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1519   -2.6447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  6 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
  3 20  1  0  0  0  0
  6 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  4  0  0  0  0
 27 28  4  0  0  0  0
 21 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4685

>  <JC_XSMILES>
CCC1(C)CC(CCNCC2=CC=CC=C2O)(CCO1)C3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.455

>  <W2 Pf proliferation inhibition EC50 uM>
0.0765

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.4

>  <Powder data?>
Yes

>  <IFI value>
0.018867925

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4746
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.9000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 13 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 22 29  4  0  0  0  0
  5 30  1  0  0  0  0
 30 31  1  0  0  0  0
  2 31  1  0  0  0  0
M  CHG  2  16   1  17  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4746

>  <JC_XSMILES>
CC1CCN(CCCNC2=CC=C(C=C2[N+]([O-])=O)C(=O)NC3=CC=C(C)C(F)=C3)CC1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1912

>  <W2 Pf proliferation inhibition EC50 uM>
0.33

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4752
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
   -0.1632   -4.2976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2792   -3.4808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0897   -3.3266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3614   -2.5477    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1719   -2.3935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4436   -1.6145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2541   -1.4603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5258   -0.6814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9870   -0.0566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1766   -0.2107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9048   -0.9897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0944   -1.1439    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4562   -3.1071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1918   -3.4808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6413   -2.6905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6413   -1.9431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9057   -1.5694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4562   -2.3597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1702   -1.9431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1702   -2.6905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9057   -3.0642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  1  0  0  0  0
  2 13  1  0  0  0  0
 15 21  1  0  0  0  0
 14 15  1  0  0  0  0
 13 14  1  0  0  0  0
  2 20  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
 17 19  1  0  0  0  0
 16 17  1  0  0  0  0
 19 20  1  0  0  0  0
 13 18  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4752

>  <JC_XSMILES>
CC2(CNCC1=CC=CC=C1O)C3CC4CC(C3)CC2C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1433

>  <W2 Pf proliferation inhibition EC50 uM>
0.0326

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4940
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
   -2.7512   -7.4866    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -6.2491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -7.4866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8212   -7.8991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8212   -8.7241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4886   -9.2090    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2337   -9.9937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4087   -9.9937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1537   -9.2090    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -7.8991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -7.4866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -4.1866    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235   -5.4241    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4669   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4669   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.1814   -3.7741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -9.1814   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.8489   -2.4642    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -9.5939   -1.6796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.7689   -1.6796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5140   -2.4642    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
  7 14  4  0  0  0  0
 14 15  4  0  0  0  0
  4 15  4  0  0  0  0
  2 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 30 34  1  0  0  0  0
 28 35  4  0  0  0  0
 35 36  4  0  0  0  0
 25 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4940

>  <JC_XSMILES>
O=C(NC1=CC=C(NC2=NCCN2)C=C1)C3=CC=C(C=C3)C(=O)NC4=CC=C(NC5=NCCN5)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1664

>  <W2 Pf proliferation inhibition EC50 uM>
0.02565

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.026086957

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5046
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  5 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
  2 14  1  0  0  0  0
  4 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5046

>  <JC_XSMILES>
NC1=NC(N(C2=CC=CC=C2)C(N)=N1)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0823

>  <W2 Pf proliferation inhibition EC50 uM>
0.2043

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015748031

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5109
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
   -0.6101    1.4427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0581    0.8296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3130    0.0450    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2390   -0.5681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0460   -0.3966    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0159   -1.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4690   -2.0202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2940   -2.0202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065   -2.7346    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5315   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9440   -3.4491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7690   -3.4491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1815   -4.1636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0065   -4.1636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1815   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0065   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0159   -2.6876    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2390   -3.4722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8006   -2.4327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5150   -2.8452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2295   -2.4327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9440   -2.8452    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.2295   -1.6077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9440   -1.1952    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5150   -1.1952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8006   -1.6077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
  7 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
  6 26  4  0  0  0  0
 19 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5109

>  <JC_XSMILES>
CCOC(=O)C1=C(CNCCN(CC)CC)N(C)C2=CC(Br)=C(O)C=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.515

>  <W2 Pf proliferation inhibition EC50 uM>
0.1848

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5114
  Mrv1591402191617072D          

 14 15  0  0  0  0            999 V2000
    0.2779   -0.4730    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2779   -1.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9923   -1.7105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9923   -2.5355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2779   -2.9480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4366   -2.5355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4366   -1.7105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2779   -3.7730    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0212   -4.1310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2047   -4.9353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6904   -5.5803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1346   -5.5803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6490   -4.9353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4654   -4.1310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5114

>  <JC_XSMILES>
NC1=CC=C(C=C1)N2CCCCCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1531

>  <W2 Pf proliferation inhibition EC50 uM>
0.1834

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.054545455

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5130
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    0.6411   -5.2354    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5023   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5023   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3429   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5130

>  <JC_XSMILES>
ClC1=CC=CC=C1CN2C3=C(CCCC3)C(=N)C4=C2CCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2216

>  <W2 Pf proliferation inhibition EC50 uM>
0.1744

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5251
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -2.2168   -6.0604    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.2168   -5.2354    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.9312   -4.8229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5023   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5023   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3429   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  1  0  0  0  0
  7 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5251

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(CN2C3=C(CCCC3)C(=N)C4=C2CCC4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.121

>  <W2 Pf proliferation inhibition EC50 uM>
0.1301

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5375
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
    0.7145   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
  2 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 28 31  1  0  0  0  0
 31 32  2  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 31 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5375

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)C2=NCCCN2)C3=CC=C(C=C3)C(=O)NC4=CC=C(C=C4)C5=NCCCN5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1203

>  <W2 Pf proliferation inhibition EC50 uM>
0.0932

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.052631579

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5530
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5530

>  <JC_XSMILES>
CC(CC1=CC=CC=C1)NCC2=CC=CC=C2O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.525

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00493

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.03125

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5561
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    5.8119   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0974   -1.0709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -2.7209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -2.7209    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -0.2459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    0.9916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    0.9916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -0.2459    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8060    0.3041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8060    0.8541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    2.2291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    2.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 15 21  1  0  0  0  0
 21 22  2  0  0  0  0
 10 23  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  4  0  0  0  0
  3 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5561

>  <JC_XSMILES>
COC1=CC=C2N=CC=C(C(O)C3CC4(CCN3CC4)C=C)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00682

>  <W2 Pf proliferation inhibition EC50 uM>
0.02933

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
77.68

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5576
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  2 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
M  CHG  2  21   1  22  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5576

>  <JC_XSMILES>
CC(CCC1=CC=CC=C1)NCC(O)C2=CC=CC(=C2)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2046

>  <W2 Pf proliferation inhibition EC50 uM>
0.01454

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
42.54

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5678
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    4.0168    4.0796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0970    3.1441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3670    2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1771    2.2086    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7172    2.8323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5274    2.6764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0675    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8776    3.1441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4472    1.4291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9071    0.8054    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2573    1.2732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5274    0.4936    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3375    0.3377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6075   -0.4418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0675   -1.0655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3375   -1.8450    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2573   -0.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7172   -1.5332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9071   -1.3773    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -0.5978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1771    0.0259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9873   -0.1300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 13 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5678

>  <JC_XSMILES>
CCCCN(CCCC)C(=O)CN1C=CC(=N)C2=CC=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
3.74

>  <W2 Pf proliferation inhibition EC50 uM>
<0.0001507

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5679
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8263    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5408   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 16  1  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 22  1  0  0  0  0
 17 23  4  0  0  0  0
 23 24  4  0  0  0  0
  9 24  4  0  0  0  0
 24 25  4  0  0  0  0
  6 25  4  0  0  0  0
 25 26  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5679

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C=C(OCC3CC3)C(OCC4CC4)=CC2=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
<0.00572

>  <W2 Pf proliferation inhibition EC50 uM>
<7.06E-05

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.00862069

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-60
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.0750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
  6 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-60

>  <JC_XSMILES>
CC1=CC=CC(OCC(O)CN2CCN(CC2)CC(=O)C3=CC=C(Br)C=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.896

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
~0.2138

>  <Powder data?>
No

>  <IFI value>
0.030769231

>  <Salt>
Hydrochloride

>  <Equiv of salt>
2

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-764
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 11 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-764

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2N=C(N)N=C(N)N2C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.326

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.014285714

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-777
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
   -0.2056   -1.3269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5739   -1.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2507   -1.1256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9085   -1.6236    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7333   -1.6398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2973   -1.0377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1008   -1.2251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3402   -2.0146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7762   -2.6167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9727   -2.4293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2959   -2.9010    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2796   -3.7258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9858   -4.1523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9695   -4.9772    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6757   -5.4037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6595   -6.2285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9370   -6.6269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2308   -6.2004    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2471   -5.3755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6381   -2.4030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8133   -2.3868    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 11 20  4  0  0  0  0
  4 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-777

>  <JC_XSMILES>
CC1=CN2C3=CC=CC=C3N(CCN4CCOCC4)C2=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
>2.477

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
2

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-806
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8245   -4.0962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4372   -3.4254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 15 16  1  0  0  0  0
  9 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-806

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2C(N)=NC(N)=NC2(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01378

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.045454545

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-807
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8245   -4.0962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4372   -3.4254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
 12 13  1  0  0  0  0
  6 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
  5 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
  2 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-807

>  <JC_XSMILES>
CC1=CC=C(N2C(N)=NC(N)=NC2(C)C)C(C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1053

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015151515

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-922
  Mrv1591402191617072D          

 35 37  0  0  0  0            999 V2000
    4.6735    5.2946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8209    4.4429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1487    3.6858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9682    3.5912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2960    2.8341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1156    2.7395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6073    3.4019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4269    3.3073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9186    3.9697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7382    3.8751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2299    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0495    4.4429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4434    1.9824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2630    1.8877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7547    2.5502    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.5908    1.1307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4104    1.0360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7382    0.2790    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2464   -0.3835    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.4269   -0.2888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9352   -0.9513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2630   -1.7083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1156   -0.8566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7878   -0.0996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9682   -0.0049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2795    0.5629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0991    0.4682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5577    0.1843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0495    0.8468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8690    0.7521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1968   -0.0049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0164   -0.0996    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   12.7051   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8856   -0.5727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  7 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 17 28  4  0  0  0  0
 21 28  4  0  0  0  0
 19 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-922

>  <JC_XSMILES>
CCCCCCN(CCCCCC)CC(O)C1=CC(=NC2=C(C)C=C(C)C=C12)C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
7.13

>  <W2 Pf proliferation inhibition EC50 uM>
5.94

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
51.86

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-924
  Mrv1591402191617072D          

 19 19  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
  6 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
  2 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-924

>  <JC_XSMILES>
CC1=CC(C)=C(CSC(N)=N)C(C)=C1CSC(N)=N

>  <PF proliferation inhibition 3D7 EC50 uM>
1.115

>  <W2 Pf proliferation inhibition EC50 uM>
>1.145

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2174
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    2.8579   -4.9500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2174

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(=C1)C(=O)CN2C=CC(C=C2)=NCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.397

>  <W2 Pf proliferation inhibition EC50 uM>
0.439

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Hydrobromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2579
  Mrv1591402191617072D          

 13 13  0  0  0  0            999 V2000
    0.5678    1.9393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5678    1.1143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2352    0.6294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0198    0.8843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1913    1.6913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5783    2.2433    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9760    1.9462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1475    2.7532    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5891    1.3942    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9803   -0.1553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4652   -0.8227    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1553   -0.1553    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0997    0.6294    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
  3 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
  2 13  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2579

>  <JC_XSMILES>
CC1=C(CC(N)C(O)=O)C(O)=NO1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.158

>  <W2 Pf proliferation inhibition EC50 uM>
0.302

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Hydrobromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2959
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2959

>  <JC_XSMILES>
IC1=CC=C(C=C1)C(=O)CN2C=CC(C=C2)=NCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3082

>  <W2 Pf proliferation inhibition EC50 uM>
0.448

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.81

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
Hydrobromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-307
  Mrv1591402191617072D          

 34 38  0  0  1  0            999 V2000
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  1  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 13 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
 18 17  1  0  0  0  0
 18  5  1  6  0  0  0
 18 19  1  0  0  0  0
 20 19  1  0  0  0  0
  3 20  1  0  0  0  0
 20 21  1  6  0  0  0
 22 21  1  1  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  4  0  0  0  0
 22 34  1  0  0  0  0
 26 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-307

>  <JC_XSMILES>
CC[C@H]1CN2CCC3=CC(OC)=C(OC)C=C3[C@@H]2C[C@@H]1C[C@H]4NCCC5=CC(O)=C(OC)C=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00361

>  <W2 Pf proliferation inhibition EC50 uM>
0.00423

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.02614

>  <Powder data?>
No

>  <IFI value>
0.322580645

>  <Salt>
Hydrobromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3616
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    1.3222    4.0634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    2.8259    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    2.8259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    2.0009    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2117    2.0009    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8617    2.0009    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -3.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1661   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9866   -3.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -2.9774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1426   -2.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8372   -2.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1728   -1.5563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0168   -2.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 20 27  4  0  0  0  0
 18 28  4  0  0  0  0
 15 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3616

>  <JC_XSMILES>
CCN(CC)S(=O)(=O)C1=CC=C(C=C1)C2=CSC(NC3=CC=C(C)C(C)=C3)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
>2.104

>  <W2 Pf proliferation inhibition EC50 uM>
>1.173

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
Hydrobromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4785
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
  6 28  4  0  0  0  0
 18 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4785

>  <JC_XSMILES>
CCOC(=O)C1=C(CNC2=CC=NC=C2)N(C)C3=CC(Br)=C(OC(C)=O)C=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2568

>  <W2 Pf proliferation inhibition EC50 uM>
0.3104

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
Hydrobromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4847
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    4.9675    0.9963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9675    0.1713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6820   -0.2412    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2531   -0.2412    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2531   -1.0662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9205   -1.5511    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6656   -2.3357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1505   -3.0031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8406   -2.3357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5856   -1.5511    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3556   -3.0031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6106   -3.7878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9431   -4.2727    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2757   -3.7878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4911   -4.0427    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -3.4907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0934   -3.7456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5197   -3.1936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3482   -2.3866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9613   -1.8346    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.4364   -2.1317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0495   -2.6837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5306   -3.0031    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 14 23  4  0  0  0  0
 11 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4847

>  <JC_XSMILES>
CC(=O)NC1=NC(C)=C(S1)C2=CSC(NC3=CC=C(Cl)C=C3)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1403

>  <W2 Pf proliferation inhibition EC50 uM>
0.0978

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
34.41

>  <Powder data?>
Yes

>  <IFI value>
0.058139535

>  <Salt>
Hydrobromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5067
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -2.3645    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -0.9355    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  2  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  5 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
  9 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
  8 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5067

>  <JC_XSMILES>
OC1=CC=C2C(=O)C(=C(OC2=C1CN3CCCCC3)C(F)(F)F)C4=CC=C(Cl)C=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.994

>  <W2 Pf proliferation inhibition EC50 uM>
0.1985

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012195122

>  <Salt>
Hydrobromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-833
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -1.7072   -9.0690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3716   -8.3153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8565   -7.6479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6770   -7.7341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1619   -7.0667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5210   -6.8942    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7673   -7.2298    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2746   -6.5586    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1854   -6.1405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6703   -5.4731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3348   -4.7194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5143   -4.6332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0294   -5.3006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3649   -6.0543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1787   -3.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5912   -3.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0392   -2.5519    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6282   -3.7080    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2413   -4.2600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  4  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 20 29  4  0  0  0  0
 24 29  4  0  0  0  0
 18 30  4  0  0  0  0
 15 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-833

>  <JC_XSMILES>
CCN(CC)S(=O)(=O)C1=CC=C(C=C1)C2=CSC(=NC3=CC=CC4=CC=CC=C34)N2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0609

>  <W2 Pf proliferation inhibition EC50 uM>
>1.219

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Hydrobromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1566
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
 12 13  1  4  0  0  0
  8 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
  6 17  4  0  0  0  0
 17 18  4  0  0  0  0
  3 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1566

>  <JC_XSMILES>
COC1=CC=C2N=C(NC(N)=NC)N=C(C)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.662

>  <W2 Pf proliferation inhibition EC50 uM>
0.725

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.036231884

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1715
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -0.0978    0.7018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8123    0.2893    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8123   -0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4798   -1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2248   -1.8053    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3998   -1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1449   -1.0206    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0851   -2.4727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5700   -3.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5823   -2.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7525   -1.9878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2644   -0.7657    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
   -3.0490   -0.5108    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6621   -1.0628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4467   -0.8079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6182   -0.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0051    0.5512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2205    0.2962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0094    0.0189    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5615    0.6320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3065    1.4166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4996    1.5882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9475    0.9751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2025    0.1905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5193   -1.5503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9673   -2.1634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2222   -2.9480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0292   -3.1196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5812   -2.5065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3263   -1.7218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  3  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  4 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 12 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 12 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  CHG  1  12   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1715

>  <JC_XSMILES>
CSC1=C(N=C(O1)C(C)(C)C)[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.296

>  <W2 Pf proliferation inhibition EC50 uM>
0.438

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.82

>  <Powder data?>
No

>  <IFI value>
0.232

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1813
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9012    2.6145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5657    3.3682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7452    3.2820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  4  0  0  0  0
 14 15  2  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  8 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1813

>  <JC_XSMILES>
CCCCCCCN1C2=C(CCC2)C(=N)C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.277

>  <W2 Pf proliferation inhibition EC50 uM>
0.231

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.86

>  <Powder data?>
Yes

>  <IFI value>
0.136363636

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2331
  Mrv1591402191617072D          

 11 10  0  0  0  0            999 V2000
    0.4694   -1.7521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4694   -1.0116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1718   -0.6413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1108   -0.6413    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
    1.4810   -1.2826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7521   -0.2711    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7521    0.4694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3934   -0.6413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7405    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1108    0.6413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2331

>  <JC_XSMILES>
CN(C)[P+](C)(N(C)C)N(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.442

>  <W2 Pf proliferation inhibition EC50 uM>
0.382

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.123595506

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2480
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8171   -2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1527   -1.5818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9732   -1.6680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  4  0  0  0  0
 15 16  2  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
  8 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2480

>  <JC_XSMILES>
CCCCCCCN1C2=C(CCCC2)C(=N)C3=C1CCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0693

>  <W2 Pf proliferation inhibition EC50 uM>
0.0914

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.725

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2582
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    4.9524    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.8974   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7044   -1.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9594   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4073   -2.6088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6004   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3454   -1.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  6 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
  5 22  1  0  0  0  0
 22 23  2  0  0  0  0
M  CHG  1   7   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2582

>  <JC_XSMILES>
CC1=[N+](C)C2=C(N1C3=CC=CC=C3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00655

>  <W2 Pf proliferation inhibition EC50 uM>
0.01288

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.427

>  <Powder data?>
No

>  <IFI value>
0.333333333

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2669
  Mrv1591402191617072D          

 16 16  0  0  0  0            999 V2000
    0.0000    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.8250    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
M  CHG  3   2   1  14   1  15  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2669

>  <JC_XSMILES>
C[N+](C)(C)CC(=C)C1=CC=C(C=C1)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.317

>  <W2 Pf proliferation inhibition EC50 uM>
0.2794

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.007462687

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2969
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
  9 20  1  0  0  0  0
 20 21  2  0  0  0  0
  6 22  4  0  0  0  0
  2 22  4  0  0  0  0
M  CHG  1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2969

>  <JC_XSMILES>
C[N+]1=CC=CC(CNC2=C(Cl)C(=O)C3=CC=CC=C3C2=O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1268

>  <W2 Pf proliferation inhibition EC50 uM>
0.2128

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3031
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
  4 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  3 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3031

>  <JC_XSMILES>
CC[N+]1=C(\C=C\C2=CC(Br)=CC=C2OC)C=CC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1547

>  <W2 Pf proliferation inhibition EC50 uM>
0.202

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.074380165

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3436
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
  4 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3436

>  <JC_XSMILES>
CC[N+]1=C(\C=C\C2=CC=C(F)C=C2)C=CC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1222

>  <W2 Pf proliferation inhibition EC50 uM>
0.1396

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.051020408

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4184
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.4161   -5.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.0300   -5.5585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 11 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  8 23  4  0  0  0  0
 18 23  4  0  0  0  0
  5 24  4  0  0  0  0
 24 25  4  0  0  0  0
  2 25  4  0  0  0  0
 25 26  1  0  0  0  0
M  CHG  1  25   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4184

>  <JC_XSMILES>
CC1=CC=C(CCN2C(C)=C(C3=CC=CC=C3)C4=CC=CC=C24)C=[N+]1C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.647

>  <W2 Pf proliferation inhibition EC50 uM>
0.69

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012195122

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4338
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  6 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
  5 18  4  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4338

>  <JC_XSMILES>
CCCCC1=C(CCC)C(=N)C2=CC=CC=C2N1C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3113

>  <W2 Pf proliferation inhibition EC50 uM>
0.422

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
71.94

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-440
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    1.6204   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -2.2539    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.7474   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184   -1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204    1.3184    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
  8 18  4  0  0  0  0
 18 19  4  0  0  0  0
  5 19  4  0  0  0  0
M  CHG  1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-440

>  <JC_XSMILES>
C[N+](C)(C)C1=CC=C2C=C(Br)C3=CC=CC=C3C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.759

>  <W2 Pf proliferation inhibition EC50 uM>
1.367

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-462
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    3.8904    0.1425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3384    0.7556    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5314    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2765   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4695   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9175    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0925    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5214    0.5840    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.3284    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5834    1.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3903    1.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6453    2.4963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0932    3.1094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2863    2.9379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0313    2.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0024    2.1816    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7436    2.5438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3349    2.6666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4188    2.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    1.5105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1724    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9794    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 10 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
  6 24  4  0  0  0  0
 24 25  4  0  0  0  0
  3 25  4  0  0  0  0
 23 26  4  0  0  0  0
  7 26  4  0  0  0  0
 18 26  1  0  0  0  0
M  CHG  1  10   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-462

>  <JC_XSMILES>
COC1=CC=C2N3CCN(CC4=CC=CC=C4)C5=[N+](C)CCC(C2=C1)=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
0.442

>  <W2 Pf proliferation inhibition EC50 uM>
1.338

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-902
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -12.7875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 16 28  4  0  0  0  0
 12 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  CHG  1  28   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-902

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)\C=C\C2=CC=CC(\C=C\C3=CC=C(C=C3)N(C)C)=[N+]2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2101

>  <W2 Pf proliferation inhibition EC50 uM>
0.2963

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.533

>  <Powder data?>
No

>  <IFI value>
0.25

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-122
  Mrv1591402191617072D          

 20 23  0  0  0  0            999 V2000
    4.2729    2.4671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2637    1.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5447    1.2377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8349    1.6581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8441    2.4831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5631    2.8876    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5354    0.4127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2747    0.0465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8857    0.6008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6713    0.3489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8459   -0.4575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2349   -1.0118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4493   -0.7598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9277   -1.3991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1028   -1.3898    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5956   -0.7391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7882    0.0631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0847    0.4941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4574   -0.0417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7732   -0.8039    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  3  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
  7 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-122

>  <JC_XSMILES>
C1CC(CCN1)=C2C3=CC=CC=C3CSC4=C2C=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.088

>  <W2 Pf proliferation inhibition EC50 uM>
4.41

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
13.05

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Oxalate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1322
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
  6 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1322

>  <JC_XSMILES>
CCN(CC)C(CN1CCN(CC1)CC(C)C(=O)C2=CC=C(O)C=C2)C3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.95

>  <W2 Pf proliferation inhibition EC50 uM>
4.31

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.96

>  <Powder data?>
Yes

>  <IFI value>
0.010526316

>  <Salt>
Oxalate

>  <Equiv of salt>
3

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2491
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2491

>  <JC_XSMILES>
COC1=CC=CC=C1N2CCN(CC2)C3CCN(CC3)C4CCC(CC4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2927

>  <W2 Pf proliferation inhibition EC50 uM>
0.67

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.21

>  <Powder data?>
Yes

>  <IFI value>
0.034482759

>  <Salt>
Oxalate

>  <Equiv of salt>
3

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1772
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  2 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1772

>  <JC_XSMILES>
OC(COCC1=CC=CC=C1)CN2CCN(CC2)C(=O)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.618

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.027027027

>  <Salt>
Oxalate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1894
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1894

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1OC)C(=O)N2CCN(CC2)CC3=CC=CC(Br)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
5.58

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011235955

>  <Salt>
Oxalate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1069
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    1.5395   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
  2 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1069

>  <JC_XSMILES>
O=S(=O)(N1CCN(CC1)CC2CNCCO2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.767

>  <W2 Pf proliferation inhibition EC50 uM>
0.332

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.22

>  <Powder data?>
No

>  <IFI value>
0.014084507

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
3

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1597
  Mrv1591402191617072D          

 32 33  0  0  0  0            999 V2000
    4.0168    5.7687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5569    5.1450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3670    5.3010    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9071    4.6773    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7172    4.8332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2573    4.2096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9873    3.4300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5274    2.8064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2573    2.0268    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4472    1.8709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9071    2.4946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1771    1.0914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3670    0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0970    0.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7467    0.6236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9366    0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0168   -0.7796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2066   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7974    1.4032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6075    1.5591    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5274    0.6236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0675    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7974   -0.7796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3375   -1.4032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0675   -2.1827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2573   -2.3387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9873   -3.1182    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.7172   -1.7150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9873   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1771    3.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370    3.8978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
  9 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
  7 31  4  0  0  0  0
 31 32  4  0  0  0  0
  4 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1597

>  <JC_XSMILES>
CCOC1=CC=C(CN(C(C)CCCN(CC)CC)C(=O)COC2=CC=C(Cl)C=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.387

>  <W2 Pf proliferation inhibition EC50 uM>
1.324

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.9

>  <Powder data?>
Yes

>  <IFI value>
0.027027027

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4839
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752    0.3126    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429    4.0641    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710    3.7211    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 16 23  4  0  0  0  0
 12 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
  9 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4839

>  <JC_XSMILES>
CC1=CC=CC=C1CN2C(=N)N(CC(O)C3=CC=C(Cl)C(Cl)=C3)C4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1353

>  <W2 Pf proliferation inhibition EC50 uM>
0.0384

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
13.28

>  <Powder data?>
Yes

>  <IFI value>
0.032258065

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-202
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    6.2102    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-202

>  <JC_XSMILES>
COC1=CC=CC=C1CN2CCC3=C(C2)SC(=N3)C4=CN=CC=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
9.23

>  <W2 Pf proliferation inhibition EC50 uM>
4.44

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
22.99

>  <Powder data?>
Yes

>  <IFI value>
0.098591549

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2049
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2049

>  <JC_XSMILES>
COC1=CC=CC=C1CN2CCC(CC2)S(=O)(=O)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.349

>  <W2 Pf proliferation inhibition EC50 uM>
0.0523

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.082

>  <Powder data?>
No

>  <IFI value>
0.04109589

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2169
  Mrv1591402191617072D          

 35 37  0  0  0  0            999 V2000
    8.3540    0.6759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9415   -0.0385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1165   -0.0385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7040   -0.7530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8790   -0.7530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4665   -0.0385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8790    0.6759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7040    0.6759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6415   -0.0385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2290    0.6759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2290   -0.7530    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4040   -0.7530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9915   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4040   -2.1820    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7540   -2.1820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0896   -2.9356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4765   -3.4877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7620   -3.0752    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9336   -2.2682    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3815   -1.6551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4255   -1.8266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9775   -1.2135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7225   -0.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2746    0.1842    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0844   -0.2574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3394    0.5272    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.6365   -0.8705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5627   -4.3081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6490   -5.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7423   -4.3944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3832   -4.2219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6415   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2290   -2.1820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 21 28  4  0  0  0  0
 18 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
 11 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2169

>  <JC_XSMILES>
CCC1=CC=C(C=C1)C(=O)N(CC(=O)NC2=CC(=NN2C3=CC=C(Cl)C(Cl)=C3)C(C)(C)C)C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.727

>  <W2 Pf proliferation inhibition EC50 uM>
3.86

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
87.78

>  <Powder data?>
Yes

>  <IFI value>
0.021052632

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2239
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    7.6391    6.0604    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    4.8229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2239

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C2CN(CCO2)C(=O)C3=CC=C4OCOC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.632

>  <W2 Pf proliferation inhibition EC50 uM>
4.11

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.01369863

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2435
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3731   -6.5955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1800   -6.7670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5925   -6.0525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0405   -5.4394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 10  1  0  0  0  0
  4 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  2 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 21 29  4  0  0  0  0
 29 30  4  0  0  0  0
 18 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2435

>  <JC_XSMILES>
O=C(NC(CN1CCCC1)C2=CC=CC=C2)NC3=CC=C(OC4=CC=CC=C4)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.355

>  <W2 Pf proliferation inhibition EC50 uM>
0.476

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
13.63

>  <Powder data?>
Yes

>  <IFI value>
0.070422535

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2696
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -7.1447   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -9.4875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 22 29  4  0  0  0  0
 19 30  4  0  0  0  0
 15 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2696

>  <JC_XSMILES>
CN(C)CCNC(=O)C1=CC=C(C=C1)C2=CN=CC(NCC3=CC=C(Cl)C(Cl)=C3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.64

>  <W2 Pf proliferation inhibition EC50 uM>
0.2836

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.32

>  <Powder data?>
Yes

>  <IFI value>
0.021276596

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3119
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
  9 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3119

>  <JC_XSMILES>
COC1=CC=C(C=N1)C(OCC(=O)N2CCN(CC2)CC3=CC=CC=C3)C4=CC=C(F)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.733

>  <W2 Pf proliferation inhibition EC50 uM>
0.1868

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028846154

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3404
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
  9 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3404

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(OCC(=O)N2CCSCC2)C3=CC=NC=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.35

>  <W2 Pf proliferation inhibition EC50 uM>
1.446

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.009803922

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
2

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3521
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1904   -1.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5253   -1.1651    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 14 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3521

>  <JC_XSMILES>
OCCN1CCN(CC1)C(=O)COC(C2=CC=CS2)C3=CC=CN=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.286

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.039215686

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
3

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3789
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
   -5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 10 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3789

>  <JC_XSMILES>
NCCCNC(=O)COC(C1=CC=CC=C1)C2=CC=CN=C2Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0817

>  <W2 Pf proliferation inhibition EC50 uM>
0.1

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019417476

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
3

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3969
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  2  0  0  0  0
  9 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3969

>  <JC_XSMILES>
CCN(CC)CCN1C(NC2=CC=CC=C2C1=O)C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.37

>  <W2 Pf proliferation inhibition EC50 uM>
0.455

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
53.34

>  <Powder data?>
Yes

>  <IFI value>
0.036585366

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4231
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 17 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
  5 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 35 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4231

>  <JC_XSMILES>
COC1=CC(=CC=C1OC2CCN(CC2)CC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)NCCC5=CC=CC=N5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.44

>  <W2 Pf proliferation inhibition EC50 uM>
0.0864

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.95

>  <Powder data?>
Yes

>  <IFI value>
0.01369863

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4232
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.1907    3.6207    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.9753    3.8756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2302    3.0910    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7204    4.6602    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7599    4.1305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9314    4.9375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7161    5.1925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3292    4.6404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1576    3.8335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3730    3.5785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1138    4.8954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3687    5.6800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1937    5.6800    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4487    4.8954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4232

>  <JC_XSMILES>
FC(F)(F)C1=CC=C(C=C1)C2CNCC2C(=O)NCC3=CC=C4OCOC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.325

>  <W2 Pf proliferation inhibition EC50 uM>
0.362

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
54.3

>  <Powder data?>
Yes

>  <IFI value>
0.01369863

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4394
  Mrv1591402191617072D          

 14 15  0  0  0  0            999 V2000
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6288   -2.9346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0992   -1.8951    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6684   -2.4049    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
  2 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4394

>  <JC_XSMILES>
CC1=NC2=CC=CC=C2N1S(C)(=O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0596

>  <W2 Pf proliferation inhibition EC50 uM>
0.0543

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018181818

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4613
  Mrv1591402191617072D          

 38 43  0  0  0  0            999 V2000
   -2.2768   -4.2590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3630   -5.0795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7499   -5.6315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429   -5.4600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3909   -6.0731    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400   -4.0623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0855   -6.3852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9060   -6.2990    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0775   -5.4920    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6730   -7.0997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8480   -7.0997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4355   -7.8142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8480   -8.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6730   -8.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0855   -7.8142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 17 22  4  0  0  0  0
 15 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
  3 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
  2 32  4  0  0  0  0
 30 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4613

>  <JC_XSMILES>
CC1=C(C(=O)N2CCC(CC2)CNC3=C(N=C4C=CC=CN34)C5=CC=C(F)C=C5)C(=NO1)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.674

>  <W2 Pf proliferation inhibition EC50 uM>
0.1778

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
44.96

>  <Powder data?>
Yes

>  <IFI value>
0.055555556

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4670
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -12.7875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
 12 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
  9 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4670

>  <JC_XSMILES>
CCC(C)CNC(=O)C1=CC=C(OC2CCN(CC2)CC3CCCCC3)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0782

>  <W2 Pf proliferation inhibition EC50 uM>
0.0484

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>13.19

>  <Powder data?>
No

>  <IFI value>
0.027777778

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4691
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8761   -0.4477    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8365    0.0820    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3464   -1.4873    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4691

>  <JC_XSMILES>
COC1=CC=C(CNC(=O)C2CNCC2C3=CC=C(C=C3)C(F)(F)F)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1652

>  <W2 Pf proliferation inhibition EC50 uM>
0.0857

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
24.14

>  <Powder data?>
Yes

>  <IFI value>
0.014084507

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4984
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
  5 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4984

>  <JC_XSMILES>
OC1=CC=C(C=C1CNC2CCCCC2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.982

>  <W2 Pf proliferation inhibition EC50 uM>
<0.02349

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.016806723

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5173
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    2.2630    6.5386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9775    6.9511    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6920    6.5386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4064    6.9511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1209    6.5386    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8354    6.9511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8354    7.7761    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5498    6.5386    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2643    6.9511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9788    6.5386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6933    6.9511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4077    6.5386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4077    5.7136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1222    5.3011    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.1222    4.4761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7896    3.9912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5347    3.2066    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.7097    3.2066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1577    2.5935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3507    2.7650    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.0957    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6478    4.1627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4548    3.9912    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.5743    4.2461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3589    4.5011    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8292    3.4615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3193    5.0308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6933    5.3011    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9788    5.7136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
 18 23  4  0  0  0  0
 16 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 13 28  4  0  0  0  0
 28 29  4  0  0  0  0
 10 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5173

>  <JC_XSMILES>
COCCOC(=O)NCC1=CC=C(NC2=C(N=C3C=NC=CN23)C(C)(C)C)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1022

>  <W2 Pf proliferation inhibition EC50 uM>
0.01551

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.01369863

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5257
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.6534    1.5387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3862    1.0091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1831    0.4992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1633   -4.5039    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714   -1.5229    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
  7 15  4  0  0  0  0
 15 16  4  0  0  0  0
  5 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
 18 29  4  0  0  0  0
 29 30  2  0  0  0  0
 29 31  4  0  0  0  0
 15 31  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  31
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5257

>  <JC_XSMILES>
CC(C)(C)C1=NN(C2=CC=C(Cl)C=C2)C3=C1C=C(CNCC4=CC=C(Cl)C=C4)C(=O)N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.351

>  <W2 Pf proliferation inhibition EC50 uM>
0.1289

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.055555556

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5431
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    9.7006    3.1257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7006    2.3007    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.9862    1.8882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9862    1.0632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717    0.6507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572    1.0632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572    1.8882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717    2.3007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717    3.1257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572    3.5382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427    3.1257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283    3.5382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283    4.3632    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427    4.7757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572    4.3632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138    4.7757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138    5.6007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    6.0132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849    5.6007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    6.0132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    6.8382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849    7.2507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    6.8382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283    6.0132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283    6.8382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427    7.2507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572    6.8382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572    6.0132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427    5.6007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717   -0.1743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572   -0.5868    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.9862   -0.5868    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.9862   -1.4118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3987   -2.1263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.1263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 17 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
  5 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5431

>  <JC_XSMILES>
COC1=CC(=CC=C1OC2CCN(CC2)CC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)NC5CC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0444

>  <W2 Pf proliferation inhibition EC50 uM>
0.01847

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.5

>  <Powder data?>
Yes

>  <IFI value>
0.027777778

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5490
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    4.1960   -5.8286    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4509   -5.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2579   -4.8724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8099   -5.4855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6169   -5.3140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1689   -5.9271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9140   -6.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1070   -6.8832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5550   -6.2701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8989   -4.4309    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919   -4.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 17 25  4  0  0  0  0
 20 25  4  0  0  0  0
 18 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 15 32  4  0  0  0  0
 32 33  4  0  0  0  0
 12 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5490

>  <JC_XSMILES>
O=C(CC1=CC=CC=C1)NCC2=CC=C(NC3=C(N=C4C=CC=CN34)C5=CC=CN=C5)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0342

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00613

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.041666667

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-72
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
  6 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-72

>  <JC_XSMILES>
COC1=CC=C(SC2CCN(CC2)C3CCOCC3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.466

>  <W2 Pf proliferation inhibition EC50 uM>
0.358

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.2396

>  <Powder data?>
No

>  <IFI value>
0.013888889

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-83
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    7.5706   -1.7343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2850   -2.1468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2850   -2.9718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9995   -1.7343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7140   -2.1468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7140   -2.9718    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4284   -1.7343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4284   -0.9093    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.1429   -2.1468    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.8574   -1.7343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5719   -2.1468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2863   -1.7343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0008   -2.1468    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.7153   -1.7343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.8015   -0.9138    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.6085   -0.7423    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   16.0210   -1.4567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.8279   -1.6283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0829   -2.4129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.5309   -3.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7239   -2.8545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.4689   -2.0698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-83

>  <JC_XSMILES>
CC(C)CC(N)C(=O)NCCCNC1=NSC2=CC=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
2.82

>  <W2 Pf proliferation inhibition EC50 uM>
>12.09

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.91

>  <Powder data?>
Yes

>  <IFI value>
0.208333333

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-870
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -2.6932   -2.6459    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4382   -3.4305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9903   -4.0436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7972   -3.8721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3493   -4.4852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1562   -4.3137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4112   -3.5290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8591   -2.9160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0522   -3.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6313   -3.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3763   -4.3867    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0792   -2.9890    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2508   -2.1820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5363   -1.7695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2587   -3.0752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 18 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-870

>  <JC_XSMILES>
NC(CC1=CC=CC=C1)C(=O)N2CCC(C2)NC3=NSC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
1.114

>  <W2 Pf proliferation inhibition EC50 uM>
1.509

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.67

>  <Powder data?>
No

>  <IFI value>
0.101449275

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-980
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    4.3652   -4.7529    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0797   -4.3404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0797   -3.5154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7942   -3.1029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5086   -3.5154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2231   -3.1029    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9376   -3.5154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6521   -3.1029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6521   -2.2779    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.3665   -3.5154    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0810   -3.1029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0810   -2.2779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3665   -1.8654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3665   -1.0404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0810   -0.6279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0810    0.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7955    0.6096    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7955    1.4346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1280    1.9195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3830    2.7041    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.2080    2.7041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7600    3.3172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5670    3.1457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8219    2.3611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2699    1.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4629    1.9195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7955   -1.0404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7955   -1.8654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5086   -4.3404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7942   -4.7529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 18 26  4  0  0  0  0
 21 26  4  0  0  0  0
 15 27  4  0  0  0  0
 27 28  4  0  0  0  0
 12 28  4  0  0  0  0
  5 29  4  0  0  0  0
 29 30  4  0  0  0  0
  2 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-980

>  <JC_XSMILES>
ClC1=CC=C(OCC(=O)NCC2=CC=C(CNC3=NOC4=CC=CC=C34)C=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
3.098

>  <W2 Pf proliferation inhibition EC50 uM>
7.29

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
66.16

>  <Powder data?>
Yes

>  <IFI value>
0.055555556

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2355
  Mrv1591402191617072D          

 25 29  0  0  0  0            999 V2000
   -0.6225   -2.5542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2209   -3.2749    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6040   -3.2875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0056   -4.0081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8305   -4.0207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2538   -3.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8523   -2.5919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0274   -2.5793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6258   -1.8587    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1991   -1.8461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0788   -3.3251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5021   -2.6170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3270   -2.6295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7503   -1.9214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5752   -1.9340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9768   -2.6546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7811   -2.8384    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8548   -3.6601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0961   -3.9842    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5535   -3.3627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7286   -3.3502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3052   -4.0583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4803   -4.0458    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.0570   -4.7539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -4.7413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 11 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  5 25  1  0  0  0  0
M  CHG  1  23   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2355

>  <JC_XSMILES>
COC1=CC2=C(C=C1OC)C3=CC4=CC=C5OCOC5=C4C=[N+]3CC2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1034

>  <W2 Pf proliferation inhibition EC50 uM>
0.2333

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.25

>  <Powder data?>
No

>  <IFI value>
0.040650407

>  <Salt>
Sulfate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3943
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -0.7314   -3.6118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1913   -2.9882    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6188   -3.1441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1589   -2.5204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8889   -1.7409    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.1173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9690   -2.6764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2391   -3.4559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0492   -3.6118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5893   -2.9882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3994   -3.1441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9395   -2.5204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7497   -2.6764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0197   -3.4559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8298   -3.6118    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3699   -2.9882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4796   -4.0796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7497   -4.8591    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2096   -5.4827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6695   -3.9236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1294   -4.5473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3193   -4.3914    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7792   -5.0150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9690   -4.8591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6990   -4.0796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8889   -3.9236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  4  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  8 25  4  0  0  0  0
 25 26  4  0  0  0  0
  3 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3943

>  <JC_XSMILES>
COC1=C(OC)C=C2C3CC4=CC=C(OC)C(OC)=C4CN3CCC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.599

>  <W2 Pf proliferation inhibition EC50 uM>
0.871

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.006802721

>  <Salt>
Sulfate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-801
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3276    0.1930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3882    0.1930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
  5 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-801

>  <JC_XSMILES>
COC1=CC2=C(C=C1OC)C(CCCCCl)=NC(C)(C)C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.343

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Sulfate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3004
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -0.6358    3.0630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0957    2.4393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.5952    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9845    3.3748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7946    3.5307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2546    1.9716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0647    2.1275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6048    1.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3347    0.7243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8748    0.1007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6850    0.2566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2251   -0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0352   -0.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3052    0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7651    1.1921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9550    1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4149    1.6598    0.0000 O   0  3  0  0  0  0  0  0  0  0  0  0
    6.1154    0.7243    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3854    1.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8453    2.1275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6555    0.1007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4656    0.2566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5246    0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2546   -0.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4444   -0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0957    0.2566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1744    1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9845    1.1921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
  6 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  CHG  1  17   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3004

>  <JC_XSMILES>
CCN(CC)C1=CC2=C(N=C3C=CC(C=C3O2)=[N+](CC)CC)C4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
0.865

>  <W2 Pf proliferation inhibition EC50 uM>
0.826

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
39.76

>  <Powder data?>
Yes

>  <IFI value>
0.145454545

>  <Salt>
Acetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3797
  Mrv1591402191617072D          

 13 13  0  0  0  0            999 V2000
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
  6 13  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3797

>  <JC_XSMILES>
CNCC(O)C1=CC=C(Cl)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.837

>  <W2 Pf proliferation inhibition EC50 uM>
0.0991

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Tartrate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2175
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    6.0645   -3.7223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8747   -3.8782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4148   -3.2546    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6848   -1.8514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2249   -3.4105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7650   -2.7868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5751   -2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1152   -2.3191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8452   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9253   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4654   -1.8514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1954   -1.0718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7355   -0.4482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5456   -0.6041    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.8156   -1.3836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6258   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.8958   -2.3191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7060   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.9760   -3.2546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.4359   -3.8782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6258   -3.7223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3557   -2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5456   -2.7868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2756   -2.0073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 12 25  4  0  0  0  0
 16 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2175

>  <JC_XSMILES>
CCN(CC)CCCC(C)NC1=CC=NC2=CC3=CC=CC=C3C=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0901

>  <W2 Pf proliferation inhibition EC50 uM>
0.933

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.26

>  <Powder data?>
Yes

>  <IFI value>
0.092307692

>  <Salt>
Phosphate

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3423
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3423

>  <JC_XSMILES>
CC1CCCCN1CC(=O)N2CCN(CC2)C(=O)CN3CCCCC3C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.0603

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>4.25

>  <Powder data?>
No

>  <IFI value>
0.037037037

>  <Salt>
Formate

>  <Equiv of salt>
2

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3449
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  2 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 14 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3449

>  <JC_XSMILES>
O=C(CNCCC1=CC=CC=C1)NC(C2=CC=CC=C2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
5.96

>  <W2 Pf proliferation inhibition EC50 uM>
0.623

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
45.35

>  <Powder data?>
Yes

>  <IFI value>
0.018181818

>  <Salt>
Formate

>  <Equiv of salt>
2

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-371
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  4  0  0  0  0
 11 12  4  0  0  0  0
  3 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-371

>  <JC_XSMILES>
COC1=CC(OC)=C(OC)C=C1CN2CCN(CC2)C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.014

>  <W2 Pf proliferation inhibition EC50 uM>
>1.476

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Formate

>  <Equiv of salt>
2

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1560
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -3.4349   -6.6087    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7204   -6.1962    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7205   -5.3712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0060   -4.9587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0061   -4.1337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2916   -3.7211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.1336    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.1373   -3.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -2.8960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5772   -2.4836    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -2.4835    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -1.6585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -1.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5873   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -0.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.9586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2915   -5.3711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  4  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 15 16  1  0  0  0  0
 14 19  1  0  0  0  0
 12 20  1  0  0  0  0
 18 19  1  0  0  0  0
 16 21  1  0  0  0  0
 18 20  1  0  0  0  0
 17 18  1  0  0  0  0
 12 21  1  0  0  0  0
 14 15  1  0  0  0  0
  7 22  4  0  0  0  0
 22 23  4  0  0  0  0
  4 23  4  0  0  0  0
M  CHG  1   7   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1560

>  <JC_XSMILES>
ON=CC1=CC=[N+](CC(=O)NC23CC4CC(CC(C4)C2)C3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.074

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
42.2

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1618
  Mrv1591402191617072D          

 28 29  0  0  0  0            999 V2000
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  9 22  4  0  0  0  0
 22 23  4  0  0  0  0
  6 23  4  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  CHG  1  16   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1618

>  <JC_XSMILES>
CCC(C)(C)C1=CC=C(OCCOCC[N+]2=CC=CC=C2)C(=C1)C(C)(C)CC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.96

>  <W2 Pf proliferation inhibition EC50 uM>
0.844

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.2

>  <Powder data?>
Yes

>  <IFI value>
0.065217391

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1731
  Mrv1591402191617072D          

 33 38  0  0  0  0            999 V2000
   -0.5615   -2.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2627   -2.3457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2369   -1.5211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9382   -1.0865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6652   -1.4765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7770   -2.2939    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5889   -2.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0235   -3.1414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8481   -3.1156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2381   -2.3886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0627   -2.3628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4527   -1.6358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0181   -0.9346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1935   -0.9604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8035   -1.6874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9789   -1.7131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4080   -1.1176    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5542   -0.3056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5099   -1.1311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1913   -1.5657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9551   -1.2539    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.1517   -0.4527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4877   -1.8839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3123   -1.9097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7469   -1.2084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5715   -1.2342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9615   -1.9612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5269   -2.6624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7023   -2.6367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2677   -3.3379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4431   -3.3122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0531   -2.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2519   -2.3885    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  4  3  1  4  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  1  0  0  0  0
  5 17  1  0  0  0  0
 17 18  1  0  0  0  0
  3 19  2  0  0  0  0
 19 20  1  4  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 23 32  4  0  0  0  0
 32 33  4  0  0  0  0
 20 33  4  0  0  0  0
M  CHG  1  21   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1731

>  <JC_XSMILES>
CCC(C=C1SC2=CC=C3C=CC=CC3=C2N1C)=CC4=[N+](C)C5=C6C=CC=CC6=CC=C5S4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.611

>  <W2 Pf proliferation inhibition EC50 uM>
6.37

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2473
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    3.5724   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  6  5  1  4  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  5 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
 19 20  1  0  0  0  0
M  CHG  1  12   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2473

>  <JC_XSMILES>
ClC1=CC=C(C=NNC(=O)C[N+]2=CC=CC=C2)C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
2.845

>  <W2 Pf proliferation inhibition EC50 uM>
3.38

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2886
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.2498   -4.0609    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6088    3.9926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1608    4.6056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9678    4.4341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5198    5.0472    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.2227    3.6495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6707    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 10 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
  8 26  4  0  0  0  0
 22 26  4  0  0  0  0
M  CHG  1  10   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2886

>  <JC_XSMILES>
FC1=CC=C(C=C1)C2=C[N+](CC(=O)NC3=CC=C(Cl)C=C3)=C4CCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
2.883

>  <W2 Pf proliferation inhibition EC50 uM>
2.304

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027027027

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2994
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.8018   -4.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498   -4.0609    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6707    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2227    3.6495    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.9256    2.2518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6285    0.8541    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  1  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 25  4  0  0  0  0
 21 25  4  0  0  0  0
M  CHG  1  11   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2994

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C[N+](CC3=CC=C(Cl)C=C3Cl)=C4CCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1891

>  <W2 Pf proliferation inhibition EC50 uM>
0.667

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
31.82

>  <Powder data?>
Yes

>  <IFI value>
0.047619048

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3201
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919    3.2065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8989    3.0350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8370    3.9911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0300    4.1626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710    3.7211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161    4.5057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 15 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
  9 31  4  0  0  0  0
 31 32  1  0  0  0  0
M  CHG  1  10   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3201

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=[N+](CC(=O)OC3CC(C)CCC3C(C)C)C4=CC=CC=C4N2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.391

>  <W2 Pf proliferation inhibition EC50 uM>
0.2332

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
13.38

>  <Powder data?>
Yes

>  <IFI value>
0.227272727

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3672
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    8.2151   -2.5883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9296   -2.1758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6440   -2.5883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3585   -2.1758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0730   -2.5883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7874   -2.1758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5019   -2.5883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2164   -2.1758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9309   -2.5883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.6453   -2.1758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.3598   -2.5883    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   16.0743   -2.1758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.0743   -1.3508    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   16.7887   -2.5883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.5032   -2.1758    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   17.5894   -1.3554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.9764   -0.8033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.3964   -1.1838    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   18.7320   -0.4302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.8089   -1.8983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.6159   -2.0698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.8708   -2.8545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.3188   -3.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5118   -3.2960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.2569   -2.5114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 15 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3672

>  <JC_XSMILES>
CCCCCCCCCCOC(=O)CN1C(C)=[N+](C)C2=CC=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.644

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
58.13

>  <Powder data?>
Yes

>  <IFI value>
0.015267176

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4189
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
   -1.4289    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    9.2411    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.7661    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674    4.2187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    4.2187    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
  4 17  4  0  0  0  0
M  CHG  1   7   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4189

>  <JC_XSMILES>
CN(C)C1=CC=[N+](CC(=O)C2=CC=CS2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.649

>  <W2 Pf proliferation inhibition EC50 uM>
0.688

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.032258065

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4249
  Mrv1591402191617072D          

 23 27  0  0  0  0            999 V2000
    3.4939   -1.8693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2939   -1.0689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8871   -0.4955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7101   -0.5526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0188    0.2125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.2458    1.0057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0462    1.2057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6196    0.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3926   -0.1807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5922   -0.3807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3865    0.7425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6871    0.3049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8939    0.5319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3008   -0.0415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5008   -0.8419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9076   -1.4153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1145   -1.1883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9145   -0.3879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1213   -0.1609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0787    0.6395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5145    1.2129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3076    0.9859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5076    0.1855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
  3 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  2 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 14 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  CHG  1   5   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4249

>  <JC_XSMILES>
CC1=C2C[N+]3(CCCCC3)CC2=CC4=C1C=CC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
1.287

>  <W2 Pf proliferation inhibition EC50 uM>
0.657

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015151515

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5308
  Mrv1591402191617072D          

 38 40  0  0  0  0            999 V2000
    6.5408   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.8908   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.6829   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
  2 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 37 38  1  0  0  0  0
M  CHG  2   2   1  20   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5308

>  <JC_XSMILES>
C[N+](C)(CCCC(=O)C1=CC=C(C=C1)C(=O)CCC[N+](C)(C)CC2=CC=CC=C2Cl)CC3=CC=CC=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02127

>  <W2 Pf proliferation inhibition EC50 uM>
0.1134

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Chloride

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-77
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  1  0  0  0  0
  7 17  4  0  0  0  0
 17 18  4  0  0  0  0
  4 18  4  0  0  0  0
M  CHG  1   7   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-77

>  <JC_XSMILES>
CN(C)C1=CC=[N+](CC2=C(Cl)C=CC=C2Cl)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1397

>  <W2 Pf proliferation inhibition EC50 uM>
0.598

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.642

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-880
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  3  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 10 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
M  CHG  1  10   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-880

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)C(C2=CC=C(C=C2)N(C)C)=C3C=CC(C=C3)=[N+](C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02213

>  <W2 Pf proliferation inhibition EC50 uM>
0.1703

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.434

>  <Powder data?>
Yes

>  <IFI value>
0.256756757

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-929
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
  5 11  4  0  0  0  0
  2 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
M  CHG  1  12   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-929

>  <JC_XSMILES>
CC(C(=O)C1=CC=C(C)C=C1)[N+]2=CC=C(C=C2)N(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.438

>  <W2 Pf proliferation inhibition EC50 uM>
4.04

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
35.3

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1754
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    4.5031   -1.1185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6822   -1.0366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2008   -1.7066    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3799   -1.6247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0403   -0.8728    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8985   -2.2947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3465   -1.6816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5395   -1.8532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5660   -2.7797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3110   -3.5643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0943   -3.8234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4860   -3.5643    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2311   -2.7797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4465   -2.5247    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2248   -4.3848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4711   -4.7203    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8922   -4.8697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8060   -5.6902    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.4734   -6.1751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3872   -6.9956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6335   -7.3311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9661   -6.8462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2124   -7.1818    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.0523   -6.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
  6 13  1  0  0  0  0
 13 14  2  0  0  0  0
 10 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  CHG  1  18   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1754

>  <JC_XSMILES>
CCOC(=O)C1(CC)CC(C)(OC1=O)C(=O)C[N+]2=CC=CC(Br)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.41

>  <W2 Pf proliferation inhibition EC50 uM>
0.628

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2276
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -0.1360   -5.2885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9036   -4.7588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6657   -4.2489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 13 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  CHG  1  13   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2276

>  <JC_XSMILES>
CC(C)(C)C1=CC=C(C=C1)C2=C[N+](C3=CC=CC=C3)=C4SCCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2213

>  <W2 Pf proliferation inhibition EC50 uM>
0.313

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.87

>  <Powder data?>
Yes

>  <IFI value>
0.230769231

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2431
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
   -2.5154   -0.2549    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.6904   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  4  0  0  0  0
 14 15  4  0  0  0  0
  8 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2431

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C2=CN3CCCC3=[N+]2C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2574

>  <W2 Pf proliferation inhibition EC50 uM>
3.51

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2715
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    7.7858   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -0.5396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 13 24  1  0  0  0  0
M  CHG  1  13   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2715

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)C(=O)C[N+]2=C(CC)C3=CC=C(C)N3CC2

>  <PF proliferation inhibition 3D7 EC50 uM>
2.441

>  <W2 Pf proliferation inhibition EC50 uM>
2.189

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
81.04

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3106
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    5.2520   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.0145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
 12 17  4  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3106

>  <JC_XSMILES>
C=CC[N+]1=CC=CC2=C1C=CC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
1.718

>  <W2 Pf proliferation inhibition EC50 uM>
1.896

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.111111111

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3160
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -0.5150    5.9049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2601    5.1202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5469    4.9487    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8018    4.1641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6088    3.9926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498    3.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076    1.3686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498   -4.0609    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8018   -4.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 14 21  4  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 28  4  0  0  0  0
 28 29  4  0  0  0  0
 22 29  4  0  0  0  0
M  CHG  1  14   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3160

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)C(=O)C(C)[N+]2=C3CCCN3C(=C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.506

>  <W2 Pf proliferation inhibition EC50 uM>
0.595

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
33.16

>  <Powder data?>
Yes

>  <IFI value>
0.08

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3382
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  1  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
M  CHG  1   8   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3382

>  <JC_XSMILES>
C(C1=CC=CC=C1)[N+]2=CC=C(C=C2)C3=NC4=CC=CC=C4S3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.85

>  <W2 Pf proliferation inhibition EC50 uM>
1.481

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.009708738

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3522
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    7.0714   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -0.5396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 12 22  1  0  0  0  0
M  CHG  1  12   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3522

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(=O)C[N+]2=C(C)C3=CC=C(C)N3CC2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.173

>  <W2 Pf proliferation inhibition EC50 uM>
1.286

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3650
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752    0.3126    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429    4.0641    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.3909    4.6772    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.7499    4.2357    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
  3 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
  2 22  4  0  0  0  0
 22 23  1  0  0  0  0
M  CHG  3   3   1  13   1  14  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3650

>  <JC_XSMILES>
CC1=[N+](CC(=O)C2=CC=C(C=C2)[N+]([O-])=O)C3=CC=CC=C3N1N

>  <PF proliferation inhibition 3D7 EC50 uM>
1.951

>  <W2 Pf proliferation inhibition EC50 uM>
1.136

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4082
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    7.7858   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -0.5396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 13 23  1  0  0  0  0
M  CHG  1  13   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4082

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)C(=O)C[N+]2=C(C)C3=CC=C(C)N3CC2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.632

>  <W2 Pf proliferation inhibition EC50 uM>
0.767

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4444
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    7.6391    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 18 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 28  4  0  0  0  0
 28 29  4  0  0  0  0
 22 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
M  CHG  1  12   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4444

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(=O)C[N+]2=CC=C3N(C)C(=NC3=C2)C4=CC=C(OC)C=C4OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.92

>  <W2 Pf proliferation inhibition EC50 uM>
0.512

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4610
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.6623   -2.8437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3802   -3.6190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4323   -3.7623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.2448   -5.1695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9626   -5.9447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1501   -6.0880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3802   -5.4560    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0980   -4.6808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  4 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  3  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 13 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4610

>  <JC_XSMILES>
C=CC[N+]1(CCCCC1)CC#CC2=CC=CC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.683

>  <W2 Pf proliferation inhibition EC50 uM>
0.396

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4672
  Mrv1591402191617072D          

 18 18  0  0  0  0            999 V2000
    3.5724   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -7.8375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   12.8605   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  CHG  1  13   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4672

>  <JC_XSMILES>
OCCCCCCCCCCC[N+]1=CC=CC=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1331

>  <W2 Pf proliferation inhibition EC50 uM>
0.365

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012195122

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4674
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    1.5269    4.3942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.0980    4.3942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6283    5.0262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3461    5.8015    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4663    5.9447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9966    5.3127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  2  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 13 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  CHG  1   2   1
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4674

>  <JC_XSMILES>
C[N+]1(CCOCC1)CC(=O)NNC2=C3C=CC=CC3=NC4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.637

>  <W2 Pf proliferation inhibition EC50 uM>
0.364

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4789
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
   -2.5154   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6904   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  4  0  0  0  0
 14 15  4  0  0  0  0
  8 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4789

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=CN3CCSC3=[N+]2C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.427

>  <W2 Pf proliferation inhibition EC50 uM>
0.3093

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.051851852

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4948
  Mrv1591402191617072D          

 42 46  0  0  0  0            999 V2000
   -6.3029   -5.0499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0174   -4.6374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0174   -3.8124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3029   -3.3999    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -5.5884   -3.8124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5884   -4.6374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6902   -2.6714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2530   -1.9718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8159   -1.2722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3787   -0.5725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7660    0.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3288    0.8556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5043    0.8268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1170    0.0983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5542   -0.6013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9156   -2.6714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0911   -2.6426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2666   -2.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4421   -2.5851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0548   -1.8566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2303   -1.8278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7931   -2.5275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1804   -3.2559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0049   -3.2847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9686   -2.4987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1441   -2.4699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6804   -2.4411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0677   -1.7127    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.1825   -0.8957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9474   -0.5866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5975   -1.0946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4827   -1.9115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7178   -2.2206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2831   -1.4577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1115   -0.6508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0600    0.1562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2315    0.9632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0161    1.2181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1877    2.0251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5746    2.5771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2101    2.3222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3816    1.5152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  3  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  4 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  3  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  3  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
 28 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  3  0  0  0  0
 36 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
M  CHG  2   4   1  28   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4948

>  <JC_XSMILES>
C1CC[N+](CC1)(CC#CC2=CC=CC=C2)CC#CC3=CC=C(C=C3)C#CC[N+]4(CCCCC4)CC#CC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.493

>  <W2 Pf proliferation inhibition EC50 uM>
0.2515

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
Bromide

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4979
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    0.2498   -4.0609    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076    1.3686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473    2.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 10 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
  8 21  4  0  0  0  0
 17 21  4  0  0  0  0
M  CHG  1  10   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4979

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C2=C[N+](C3=CC=CC=C3)=C4SCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3082

>  <W2 Pf proliferation inhibition EC50 uM>
0.2358

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.007246377

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5004
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    0.5469   -5.4586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8018   -4.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498   -4.0609    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076    1.3686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473    2.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 10 17  4  0  0  0  0
 13 17  4  0  0  0  0
 12 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  CHG  1  12   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5004

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)C2=C[N+](=C3SCCN23)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.421

>  <W2 Pf proliferation inhibition EC50 uM>
0.2282

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5041
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  4  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  1  6  4  0  0  0  0
  4  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  7 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  9 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  CHG  1  11   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5041

>  <JC_XSMILES>
C1=CC=C(C=C1)N2N=C(N=[N+]2C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.296

>  <W2 Pf proliferation inhibition EC50 uM>
0.2067

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.112244898

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5133
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  CHG  1   9   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5133

>  <JC_XSMILES>
COC1=CC=C(C=C1)[N+]2=C3SCCCN3C(=C2)C4=CC=C(Br)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.609

>  <W2 Pf proliferation inhibition EC50 uM>
0.1717

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-588
  Mrv1591402191617072D          

 14 14  0  0  0  0            999 V2000
   -0.6865   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0280   -2.0248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7425   -2.4373    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4569   -2.0248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4569   -1.1998    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1714   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8859   -2.0248    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9721   -1.2043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3590   -0.6523    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.7791   -1.0328    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.1916   -1.7472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0121   -1.8335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4970   -1.1660    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6396   -2.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  2  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 11 14  4  0  0  0  0
  7 14  4  0  0  0  0
M  CHG  1   9   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-588

>  <JC_XSMILES>
CCOC(=O)C[N+]1=C(N)SC(CC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.074

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-991
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  CHG  1  18   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-991

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)C2=CN3CCCSC3=[N+]2CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.648

>  <W2 Pf proliferation inhibition EC50 uM>
1.093

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2545
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   -0.0977    0.7018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8122    0.2893    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6406    1.0963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8122   -0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4797   -1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2248   -1.8052    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3998   -1.8052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1448   -1.0206    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0851   -2.4727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9056   -2.3865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3905   -3.0540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0549   -3.8076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5398   -4.4751    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.2344   -3.8938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2505   -3.2264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0710   -3.3126    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.2643   -0.7656    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
   -3.0489   -0.5106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6620   -1.0626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4466   -0.8076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6181   -0.0007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0050    0.5513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2204    0.2964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0093    0.0190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5613    0.6321    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3064    1.4167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4994    1.5882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9474    0.9751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2024    0.1905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5193   -1.5502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9673   -2.1633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2223   -2.9479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0292   -3.1194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5812   -2.5063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3263   -1.7217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  1  0  0  0  0
  5 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 17 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 17 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  CHG  1  17   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2545

>  <JC_XSMILES>
CN(C)C1=C(N=C(O1)C2=CC=C(Cl)C=C2Cl)[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2303

>  <W2 Pf proliferation inhibition EC50 uM>
0.365

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.58

>  <Powder data?>
Yes

>  <IFI value>
0.203703704

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2940
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3018   -2.1741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5314   -1.9238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  4  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  1  0  0  0  0
  5 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
  2 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  CHG  1   6   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2940

>  <JC_XSMILES>
CN(C=CC1=[N+](C)C2=CC=C(Cl)C=C2C1(C)C)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.455

>  <W2 Pf proliferation inhibition EC50 uM>
2.041

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>92.78

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3526
  Mrv1591402191617072D          

 27 31  0  0  0  0            999 V2000
    2.0328   -8.0157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7506   -7.2404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2809   -6.6084    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.5630   -5.8332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3755   -5.6899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9058   -6.3218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6237   -7.0971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8112   -7.2404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5664   -6.1960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5664   -5.3710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8519   -4.9585    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8518   -4.1335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -3.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -2.8960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -2.4835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5662   -2.8960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5663   -3.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -1.6585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -1.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5873   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -0.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  3  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
 21 22  1  0  0  0  0
 20 25  1  0  0  0  0
 18 26  1  0  0  0  0
 24 25  1  0  0  0  0
 22 27  1  0  0  0  0
 24 26  1  0  0  0  0
 23 24  1  0  0  0  0
 18 27  1  0  0  0  0
 20 21  1  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3526

>  <JC_XSMILES>
CC[N+]1(CCCCC1)CCOC2=CC=C(C=C2)C34CC5CC(CC(C5)C3)C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.008

>  <W2 Pf proliferation inhibition EC50 uM>
0.746

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
58.22

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3619
  Mrv1591402191617072D          

 36 41  0  0  0  0            999 V2000
   -1.0046   -3.0874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7892   -2.8325    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9607   -2.0255    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7144   -1.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4289   -2.1025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1434   -1.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8578   -2.1025    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8578   -2.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5723   -1.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2868   -2.1025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0012   -1.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0012   -0.8650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2868   -0.4525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5723   -0.8650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6282   -0.8695    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.2413   -0.3174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0259   -0.5724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6390   -0.0203    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4675    0.7866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6828    1.0416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0697    0.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  5  4  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  4 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
 22 27  4  0  0  0  0
 25 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 35 36  4  0  0  0  0
 28 36  4  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3619

>  <JC_XSMILES>
CC[N+]1=C(C=CN(C)C2=CC=CC=C2)N(C3=CC=CC=C3)C4=CC=C(C=C14)C5=NC6=CC=CC=C6S5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.46

>  <W2 Pf proliferation inhibition EC50 uM>
0.3145

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
26.87

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3716
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  3 13  4  0  0  0  0
  7 13  4  0  0  0  0
  4 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 15 21  1  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3716

>  <JC_XSMILES>
CC[N+]1=C(C=CC2=CC(C)=CC=C12)C=C3C=CN(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.388

>  <W2 Pf proliferation inhibition EC50 uM>
0.286

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>26.83

>  <Powder data?>
Yes

>  <IFI value>
0.078125

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3840
  Mrv1591402191617072D          

 23 22  0  0  0  0            999 V2000
    3.0407    6.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2542    5.2750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6709    4.6916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8844    3.8948    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6813    3.6813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2645    4.2645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0614    4.0510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3011    3.3114    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
    1.7178    3.8948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7178    2.7281    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9313    1.9313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3479    1.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5615    0.5511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9209    2.9416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3376    2.3583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4593    2.5718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8844    2.7281    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6709    1.9313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2542    1.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0407    0.5511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6813    2.9416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2645    2.3583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0510    1.5615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
M  CHG  1   8   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3840

>  <JC_XSMILES>
CCCN(CCC)[P+](C)(N(CCC)CCC)N(CCC)CCC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.895

>  <W2 Pf proliferation inhibition EC50 uM>
0.58

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>61.2

>  <Powder data?>
Yes

>  <IFI value>
0.078431373

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4110
  Mrv1591402191617072D          

 14 15  0  0  0  0            999 V2000
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  4  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  3 14  4  0  0  0  0
  9 14  4  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4110

>  <JC_XSMILES>
CCC1=[N+](CC)C=CN2C(C)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.61

>  <W2 Pf proliferation inhibition EC50 uM>
0.749

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.060240964

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4123
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
  3 13  4  0  0  0  0
 13 14  1  0  0  0  0
  8 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  6 17  4  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4123

>  <JC_XSMILES>
CCC1=[N+](C)C2=C3C(C=CC=C3N1C)=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.958

>  <W2 Pf proliferation inhibition EC50 uM>
0.739

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4129
  Mrv1591402191617072D          

 27 31  0  0  0  0            999 V2000
   -1.0046   -3.0874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7892   -2.8325    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9607   -2.0255    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7144   -1.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4289   -2.1025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6282   -0.8695    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.2413   -0.3174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0259   -0.5724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6390   -0.0203    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4675    0.7866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6828    1.0416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0697    0.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  6 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  3 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 19 27  1  0  0  0  0
M  CHG  1   6   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4129

>  <JC_XSMILES>
CC[N+]1=C(C)N(C2=CC=CC=C2)C3=CC=C(C=C13)C4NC5=CC=CC=C5S4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.18

>  <W2 Pf proliferation inhibition EC50 uM>
0.734

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.031746032

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4178
  Mrv1591402191617072D          

 44 47  0  0  0  0            999 V2000
    9.3164    0.2104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4914    0.2104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0789   -0.5040    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2539   -0.5040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8414   -1.2185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0164   -1.2185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6039   -0.5040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0164    0.2104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8414    0.2104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7789   -0.5040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3664    0.2104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3664   -1.2185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5414   -1.2185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1289   -1.9330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3039   -1.9330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8914   -1.2185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0664   -1.2185    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.2500   -2.0228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2500   -0.4142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7356    0.2308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0894    0.2308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6038   -0.4142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4202   -1.2185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3231   -1.5765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8914   -2.6474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3039   -3.3619    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0664   -2.6474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6539   -3.3619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1711   -3.3619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5836   -2.6474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4086   -2.6474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8211   -1.9330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6461   -1.9330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1711   -1.9330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6539   -1.9330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7789   -1.9330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3664   -2.6474    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.7616   -2.0863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1548   -2.8906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4562   -3.6586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0437   -4.3731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2279   -4.4960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6231   -3.9349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6848   -3.1122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 17 24  1  0  0  0  0
 15 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 30 34  4  0  0  0  0
 34 35  4  0  0  0  0
 27 35  4  0  0  0  0
 12 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 42 43  1  0  0  0  0
 43 44  1  0  0  0  0
 37 44  1  0  0  0  0
M  CHG  2  17   1  37   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4178

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)C(=O)C(CCC(C[N+]2(C)CCCCCC2)C(=O)C3=CC=C(OCC)C=C3)C[N+]4(C)CCCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.615

>  <W2 Pf proliferation inhibition EC50 uM>
0.693

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Iodide

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4182
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -0.4202    2.8430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2487    3.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007    4.2631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3882    4.9775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7238    5.7312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4188    4.8060    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0319    5.3580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 13 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  CHG  1   6   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4182

>  <JC_XSMILES>
CC1=CC(C)=[N+](C)N1CC(O)CN2C3=CC=CC=C3C4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
1.224

>  <W2 Pf proliferation inhibition EC50 uM>
0.691

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.010309278

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4242
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
 10  7  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  1  0  0  0  0
M  CHG  1  18   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4242

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)C=CC2=CC=C(C)C=[N+]2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.397

>  <W2 Pf proliferation inhibition EC50 uM>
0.4

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>60.47

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4361
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 10 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
  9 20  1  0  0  0  0
M  CHG  1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4361

>  <JC_XSMILES>
CN1C=CC(C=C1)=CC2=[N+](CC=C)C3=CC=CC=C3S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1715

>  <W2 Pf proliferation inhibition EC50 uM>
0.14

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
24.58

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4551
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    5.3203    2.0754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0347    2.4879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7492    2.0754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4637    2.4879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1782    2.0754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8926    2.4879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6071    2.0754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3216    2.4879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0360    2.0754    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   11.7897    2.4110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9612    3.2180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3417    1.7979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.1622    1.8841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4978    2.6378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9292    1.0834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1842    0.2988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6322   -0.3143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8252   -0.1428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2731   -0.7559    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.5702    0.6419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1223    1.2550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
  9 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  CHG  1   9   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4551

>  <JC_XSMILES>
CCCCCCCC[N+]1=C(C)N(CC)C2=CC=C(Cl)C=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.139

>  <W2 Pf proliferation inhibition EC50 uM>
0.2392

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
54.87

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4650
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
  2 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
M  CHG  3   9   1  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4650

>  <JC_XSMILES>
CN1C2=CC=CC=C2[N+](C)=C1C3=CC=C(C=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.313

>  <W2 Pf proliferation inhibition EC50 uM>
0.376

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012987013

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4665
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  5 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
 14 19  4  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4665

>  <JC_XSMILES>
CC1=[N+](C)C(CC2=CC=CC=C2)=CC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.488

>  <W2 Pf proliferation inhibition EC50 uM>
0.369

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.062992126

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4803
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  4  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
  6 19  4  0  0  0  0
 19 20  4  0  0  0  0
  3 20  4  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4803

>  <JC_XSMILES>
COC1=CC=C2SC(=CC3=CC=CC=[N+]3C)N(C)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2187

>  <W2 Pf proliferation inhibition EC50 uM>
0.3022

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4805
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  1  8  1  0  0  0  0
  7  9  2  0  0  0  0
  9 10  1  4  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 11 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
M  CHG  1  11   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4805

>  <JC_XSMILES>
[H]C1(C)CC(C)=CC(C1)=CC2=[N+](CC)C3=CC=CC=C3S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.326

>  <W2 Pf proliferation inhibition EC50 uM>
0.3004

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4823
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    4.1801   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8476   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926   -3.8062    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.7676   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0775   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8980   -4.3874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3829   -5.0548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474   -5.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2269   -5.8947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7420   -5.2273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5323   -6.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3528   -6.3897    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1968   -7.2296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6817   -7.8970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3461   -8.6507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5256   -8.7369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0407   -8.0695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3763   -7.3158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1901   -9.4906    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.6026  -10.2051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0505  -10.8182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2969  -10.4826    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5824  -10.8951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3831   -9.6621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  4  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  CHG  2   4   1  21   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4823

>  <JC_XSMILES>
C[N+]1=CN(C=C1)C2=CC=C(C=C2)C(=O)C3=CC=C(C=C3)N4C=C[N+](C)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0335

>  <W2 Pf proliferation inhibition EC50 uM>
0.02941

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.014084507

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4850
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  3  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  2  8  4  0  0  0  0
  4  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 10 19  1  0  0  0  0
M  CHG  1   8   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4850

>  <JC_XSMILES>
CC1=CC(C=C(C)O1)=CC2=[N+](C)C3=CC=CC=C3S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.03131

>  <W2 Pf proliferation inhibition EC50 uM>
0.02366

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.35

>  <Powder data?>
Yes

>  <IFI value>
0.166666667

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4969
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -2.6652   -1.4765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9382   -1.0865    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2369   -1.5211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5099   -1.1311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1913   -1.5657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9551   -1.2539    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.1517   -0.4527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4877   -1.8839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3123   -1.9097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7469   -1.2084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5715   -1.2342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9615   -1.9612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5269   -2.6624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7023   -2.6367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2677   -3.3379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4431   -3.3122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0531   -2.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2519   -2.3885    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9124   -0.2619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6136    0.1727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5879    0.9973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8609    1.3873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1596    0.9527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1854    0.1281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  4  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
 17 18  4  0  0  0  0
  5 18  4  0  0  0  0
  2 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  CHG  1   6   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4969

>  <JC_XSMILES>
CN(C=CC1=[N+](C)C2=C3C=CC=CC3=CC=C2S1)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2387

>  <W2 Pf proliferation inhibition EC50 uM>
0.1531

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
64.31

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4977
  Mrv1591402191617072D          

 30 31  0  0  0  0            999 V2000
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    4.9500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   12.1460    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8440    4.2355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6690    4.2355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0190    5.6645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    6.3789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  2  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
  7 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  CHG  1  16   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4977

>  <JC_XSMILES>
CCCCCCN1C(=O)C(C(=O)NCC[N+](CC)(CC)CC)=C(O)C2=CC=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.506

>  <W2 Pf proliferation inhibition EC50 uM>
0.236

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.054545455

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5008
  Mrv1591402191617072D          

 15 16  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
  4 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
M  CHG  1  13   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5008

>  <JC_XSMILES>
CCSC1=CC=C2C=CC=CC2=[N+]1CC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.179

>  <W2 Pf proliferation inhibition EC50 uM>
0.2269

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.007462687

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3080
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    2.0329   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.6829    0.6039    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204    1.3184    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  4  0  0  0  0
  2 17  4  0  0  0  0
M  CHG  1   6   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3080

>  <JC_XSMILES>
CC1=CC(C)=[N+]2N=C(N)C3=CC=CC=C3C2=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2483

>  <W2 Pf proliferation inhibition EC50 uM>
0.1931

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018348624

>  <Salt>
Perchlorate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3891
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
   -0.8123    0.2893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8123   -0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1449   -1.0206    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3998   -1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2248   -1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4798   -1.0206    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7097   -2.4727    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5302   -2.3865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0151   -3.0539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6796   -3.8076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1645   -4.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9850   -4.3888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3205   -3.6351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8356   -2.9677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0851   -2.4727    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
    0.5700   -3.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3905   -3.0539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8754   -3.7213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5399   -4.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7194   -4.5612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2345   -3.8938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5823   -2.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4961   -3.7781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1635   -4.2630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9172   -3.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0034   -3.1070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3360   -2.6221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7525   -1.9878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6663   -1.1673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3337   -0.6824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0874   -1.0179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1737   -1.8384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5062   -2.3233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  4 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 15 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3891

>  <JC_XSMILES>
CC1=NC(=C(O1)SCC2=CC=CC=C2)[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.456

>  <W2 Pf proliferation inhibition EC50 uM>
0.621

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
68.33

>  <Powder data?>
Yes

>  <IFI value>
0.21641791

>  <Salt>
Perchlorate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5159
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  4 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5159

>  <JC_XSMILES>
OCC[N+]1=C2C=CC=CC2=NC3=CC=C(C=C13)N4CCOCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2426

>  <W2 Pf proliferation inhibition EC50 uM>
0.0564

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
35.03

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Perchlorate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3272
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
   -1.3099   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2549   -2.1195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -1.0799    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8242   -2.1195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8792   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2917    0.0470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1167    0.0470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5292   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1167   -1.3819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2917   -1.3819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
M  CHG  1   5   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3272

>  <JC_XSMILES>
CC1=C(C)[N+]2=C(S1)SC(=C2N)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.053

>  <W2 Pf proliferation inhibition EC50 uM>
1.632

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Benzenesulfonate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-100
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  5 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  1 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-100

>  <JC_XSMILES>
C(NC1=NC(=NN=C1C2=CC=CC=C2)C3=CC=CC=N3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1821

>  <W2 Pf proliferation inhibition EC50 uM>
0.326

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.63

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1005
  Mrv1591402191617072D          

 11 11  0  0  0  0            999 V2000
   -0.1467    3.1768    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1467    2.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612    1.9393    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5678    1.9393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5678    1.1143    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2352    0.6294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9803   -0.1553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4652   -0.8227    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1553   -0.1553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0997    0.6294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8843    0.8843    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1005

>  <JC_XSMILES>
NC(=O)CN1CC(O)CC1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
5.96

>  <W2 Pf proliferation inhibition EC50 uM>
6.22

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
57.48

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1006
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6561    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4407    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4407    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1082    2.4204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6561    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
  3 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  8 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1006

>  <JC_XSMILES>
COC1=CC=C2CN(C(=O)C2=C1OC)C3=NC=C(C)S3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.081

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1007
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2411   -7.9099    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.9862   -8.6945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1612   -8.6945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9062   -7.9099    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 21 25  1  0  0  0  0
M  CHG  2  14   1  15  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1007

>  <JC_XSMILES>
CCCCCCOC1=CC=C(C=C1[N+]([O-])=O)C(C)=NNC2=NCCN2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2281

>  <W2 Pf proliferation inhibition EC50 uM>
0.791

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.32

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1008
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -3.0907   -4.7792    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3762   -4.3667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6617   -4.7792    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9473   -4.3667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9473   -3.5417    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2328   -4.7792    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4817   -4.3667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1962   -4.7792    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1962   -5.6042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4817   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2328   -5.6042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9106   -6.0167    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6251   -5.6042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6251   -4.7792    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3396   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0540   -5.6042    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4830   -5.6042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5692   -4.7837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9561   -4.2317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3762   -4.6122    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7887   -5.3267    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2367   -5.9398    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6092   -5.4129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0941   -4.7455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9146   -4.8317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2501   -5.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7652   -6.2528    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1008   -7.0065    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.9212   -7.0927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9447   -6.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 24 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1008

>  <JC_XSMILES>
CCOC(=O)N1CCC(CC1)NC(=O)CSCC2=C(C)OC(=N2)C3=CC=CC(OC)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.08

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-101
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    2.8579   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.4105    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -4.8395    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 12 18  4  0  0  0  0
  7 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  5 21  4  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-101

>  <JC_XSMILES>
FC(F)(F)C1=CC(NC(=O)NC2=CC=CC(Cl)=C2)=CC(=C1)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
3.22

>  <W2 Pf proliferation inhibition EC50 uM>
>9.99

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.46

>  <Powder data?>
Yes

>  <IFI value>
0.125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1010
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
 17 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1010

>  <JC_XSMILES>
COC1=CC=CC=C1NC(=O)C(=O)NCCC2=CC=C(OC)C(OC)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>10.31

>  <W2 Pf proliferation inhibition EC50 uM>
>10.78

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1011
  Mrv1591402191617072D          

 22 22  0  0  0  0            999 V2000
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
  2 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1011

>  <JC_XSMILES>
CC(\C=C(C)\C=C\C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2002

>  <W2 Pf proliferation inhibition EC50 uM>
0.1708

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.587

>  <Powder data?>
No

>  <IFI value>
0.226415094

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1013
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -1.6904   -3.1128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779   -2.3984    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6904   -1.6839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529   -0.9694    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404   -1.6839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529   -2.3984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2734    0.5458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4449    1.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7304    1.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1173    1.2132    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 21 22  1  0  0  0  0
 14 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1013

>  <JC_XSMILES>
CN1CCN(CC1)C(C2=CC=CO2)C3=C(O)N4N=CN=C4S3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.075

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1014
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
  4 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 19 24  4  0  0  0  0
  6 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
M  CHG  4   1  -1   2   1  25   1  26  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1014

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(=C2C=CC=NC2=C1NC3=CC=CC4=CC=CN=C34)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
8.04

>  <W2 Pf proliferation inhibition EC50 uM>
6.44

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
59.94

>  <Powder data?>
Yes

>  <IFI value>
0.1

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1015
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 10 16  4  0  0  0  0
  9 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1015

>  <JC_XSMILES>
CC1=CC=CC=C1NC(C2=CC=CC(Cl)=C2)C3=NN=NN3C4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.723

>  <W2 Pf proliferation inhibition EC50 uM>
>1.074

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1016
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
  7 20  4  0  0  0  0
 20 21  4  0  0  0  0
  4 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1016

>  <JC_XSMILES>
CN(C)C1=CC=C(NC(=O)C2=CC=CN=C2C(O)=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.32

>  <W2 Pf proliferation inhibition EC50 uM>
0.841

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.84

>  <Powder data?>
No

>  <IFI value>
0.060240964

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1017
  Mrv1591402191617072D          

 38 40  0  0  0  0            999 V2000
   -2.0647   -0.8802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2546   -1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0957   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358    0.0552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459   -0.1007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860    0.5230    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    1.3025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560    1.9262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860    2.7057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9058    1.4584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3657    0.8348    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444    0.9907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9845    0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7946    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647    1.3025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5246    1.9262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.7702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744    2.3939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444    3.1734    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358    2.2380    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758    2.8616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9058    3.6412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459    4.2648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560    4.1089    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758    5.0444    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    5.6680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961    0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362    0.9907    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164    0.0552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2265   -0.1007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4966   -0.8802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9565   -1.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2265   -2.2834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4966   -3.0630    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
  7 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 35 37  1  0  0  0  0
 37 38  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1017

>  <JC_XSMILES>
CCCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1CCC(=O)OC)C(=O)NC3=CC=CC(=C3)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.979

>  <W2 Pf proliferation inhibition EC50 uM>
1.071

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1018
  Mrv1591402191617072D          

 31 34  0  0  1  0            999 V2000
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -4.9820    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.7309   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -4.1974    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.6914   -3.9425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5198   -3.1355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0783   -4.4945    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7064   -4.2396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3195   -4.7916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1041   -4.5367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7172   -5.0887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5018   -4.8338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6733   -4.0268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0602   -3.4748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2318   -2.6678    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.2756   -3.7297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0408   -5.6495    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8658   -5.6495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1208   -6.4341    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4533   -6.9190    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7859   -6.4341    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  9  8  1  0  0  0  0
  9 10  1  0  0  0  0
 11 10  1  0  0  0  0
 11  7  1  0  0  0  0
 11 12  1  1  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 17 23  4  0  0  0  0
  9 24  1  6  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 24 28  4  0  0  0  0
  5 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
  2 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1018

>  <JC_XSMILES>
CC1=CC=C(CN2C[C@@H](C[C@H]2C(=O)NCCC3=CC=CC(Cl)=C3)N4C=NN=N4)C(C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.319

>  <W2 Pf proliferation inhibition EC50 uM>
1.119

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.45

>  <Powder data?>
No

>  <IFI value>
0.019417476

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1020
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -9.9000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  2  0  0  0  0
 24 26  4  0  0  0  0
 16 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 27 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1020

>  <JC_XSMILES>
CCN(CC)CCCC(C)NC(=O)CSC1=NC2=CC=CC=C2C(=O)N1C3=CC=CC(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.069

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.036697248

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1021
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -4.8892   -4.3131    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1747   -3.9006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1747   -3.0756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4603   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7458   -3.0756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0313   -2.6631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3168   -3.0756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6024   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6024   -1.8381    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1121   -3.0756    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8266   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5802   -2.9987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7518   -3.8057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -4.6126    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1323   -2.3856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7198   -1.6711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2718   -1.0580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0255   -1.3936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9392   -2.2141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9128   -1.8427    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7458   -3.9006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0313   -4.3131    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4603   -4.3131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  3  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  4  0  0  0  0
 11 20  4  0  0  0  0
  5 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1021

>  <JC_XSMILES>
FC1=CC=C(OCC(=O)NC2=C(C#N)C3=C(CCC3)S2)C(F)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.068

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1022
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -1.5246   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -0.8802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -1.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -1.3480    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    0.0552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9058   -0.1007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3657    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444    0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9845    0.9907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.7702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0957    1.9262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358    1.3025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459    1.4584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    2.2380    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860    0.8348    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961    0.9907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362    0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164    1.3025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763    1.9262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662    1.7702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261    2.3939    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961    3.1734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261   -1.9716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -1.8157    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -2.7512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961   -3.3748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261   -4.1543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -4.3103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459   -5.0898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -3.6866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459   -2.9071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
  6 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 31 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1022

>  <JC_XSMILES>
CCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3OC)C(=O)C4=CC=C(C)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.893

>  <W2 Pf proliferation inhibition EC50 uM>
1.068

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1025
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
  9 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1025

>  <JC_XSMILES>
COC1=CC=CC=C1N(CC(=O)N2CCCCC2)S(=O)(=O)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.067

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1026
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.5675    2.6100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7470    2.6963    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2620    2.0288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5976    1.2752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1127    0.6077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2922    0.6940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0434    1.4476    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4416    2.1151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1060    2.8687    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.9550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0500    3.7087    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1994    2.2875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8638    1.5339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0199    2.3738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324    3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2393    2.9167    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3256    2.0962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0401    1.6837    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7545    2.0962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7545    2.9212    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4690    1.6837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1835    2.0962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8979    1.6837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8979    0.8587    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6124    2.0962    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3269    1.6837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0806    2.0193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6326    1.4062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2201    0.6917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4131    0.8633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5719    1.7607    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 26 30  1  0  0  0  0
 17 31  4  0  0  0  0
 14 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1026

>  <JC_XSMILES>
COC1=CC=CC2=C1OC(=O)C(=C2)C3=CSC(NC(=O)CCC(=O)NC4CCCC4)=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.067

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1028
  Mrv1591402191617072D          

 11 10  0  0  1  0            999 V2000
    2.0625    0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    0.7145    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.8250    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    2.1434    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    2.8579    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    3.5724    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105    2.4454    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    3.2704    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  2  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1028

>  <JC_XSMILES>
N[C@@H](COP(O)(O)=O)C(O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.08

>  <W2 Pf proliferation inhibition EC50 uM>
>1.065

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1031
  Mrv1591402191617072D          

 37 42  0  0  0  0            999 V2000
   -4.0007   -1.7716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1937   -1.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6417   -2.2131    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4856   -2.8806    0.0000 O   0  3  0  0  0  0  0  0  0  0  0  0
   -2.0987   -3.4326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -4.2576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -4.6701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -4.2576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -3.4326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -3.0201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2422   -4.6701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2422   -5.4951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9566   -5.9076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6711   -5.4951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6711   -4.6701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9566   -4.2576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  3 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  4 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  1  0  0  0  0
 21 31  1  0  0  0  0
 27 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  CHG  1   5   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1031

>  <JC_XSMILES>
CCN1C(\OC2=CC=C(C=C12)C3=CC=CC=C3)=C\C=C\C4=[N+](CC)C5=CC(=CC=C5O4)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.718

>  <W2 Pf proliferation inhibition EC50 uM>
1.063

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1037
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -15.2625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -16.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1037

>  <JC_XSMILES>
COC1=CC=C(CCN2CCC(CC2)NCC3=CC=CC(=C3)N(C)C)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.806

>  <W2 Pf proliferation inhibition EC50 uM>
1.06

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1043
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    1.5745   -1.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1620   -0.8803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7495   -0.1658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8765   -0.4678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4475   -1.2928    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2669   -0.8803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2669   -0.0553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9814    0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6959   -0.0553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4103    0.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4103    1.1822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1248    1.5947    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.6959    1.5947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9814    1.1822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2669    1.5947    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.4475   -2.1178    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1150   -2.6027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8600   -3.3873    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0350   -3.3873    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2199   -2.6027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0045   -2.3478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8290   -2.3766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2662   -1.6769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8789   -0.9485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0544   -0.9197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6172   -1.6194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1193   -3.1648    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8843   -3.4738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9991   -4.2908    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7640   -4.5998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4141   -4.0919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1790   -4.4010    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.2993   -3.2749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5344   -2.9659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  1  0  0  0  0
  5 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
 21 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 33 34  4  0  0  0  0
 28 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1043

>  <JC_XSMILES>
CC(C)(C)C(\C=C\C1=CC=C(Cl)C=C1Cl)N2N=NN=C2C3(CCCCC3)NC4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.054

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1047
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
  3 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  2  0  0  0  0
 30 32  4  0  0  0  0
 22 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  1  0  0  0  0
 37 39  4  0  0  0  0
 33 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1047

>  <JC_XSMILES>
CCC(N(CCC1=CC=CC=C1)C(=O)C2=CC=C(F)C=C2)C3=NC4=CC=CC=C4C(=O)N3C5=CC=CC(Cl)=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2673

>  <W2 Pf proliferation inhibition EC50 uM>
0.069

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.656

>  <Powder data?>
No

>  <IFI value>
0.018181818

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1051
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  6 17  4  0  0  0  0
  2 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1051

>  <JC_XSMILES>
CC1=CC=CC(NC(=O)NC2=CC=CN=C2)=C1NC(=O)NC3=CC=CN=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.049

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1056
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1056

>  <JC_XSMILES>
CC1=C2C=CC=CC2=C(C3=CC=CC=C3)C4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
1.231

>  <W2 Pf proliferation inhibition EC50 uM>
0.626

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6

>  <Powder data?>
No

>  <IFI value>
0.030075188

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1057
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 15 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  2  0  0  0  0
  7 34  4  0  0  0  0
  3 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1057

>  <JC_XSMILES>
COC1=CC=CC(CCN2CC3=CC=C(C=C3N=C2\C=C\C4=CC=CC=C4)C(=O)NCC=C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.34

>  <W2 Pf proliferation inhibition EC50 uM>
1.043

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.086419753

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1059
  Mrv1591402191617072D          

 42 46  0  0  0  0            999 V2000
    0.4507    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -2.8414    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6329   -3.6421    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4614   -4.4490    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1759   -4.8615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2621   -5.6820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0158   -6.0176    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1020   -6.8381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8557   -7.1736    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4346   -7.3230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6809   -6.9874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0135   -7.4723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0997   -8.2928    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8534   -8.6284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9396   -9.4489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5208   -8.1435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7890   -4.3095    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5960   -4.4810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1480   -3.8679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9550   -4.0395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5070   -3.4264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2521   -2.6417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4451   -2.4702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8931   -3.0833    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 21 27  4  0  0  0  0
 16 28  4  0  0  0  0
 13 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
  7 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
  6 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 37 42  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1059

>  <JC_XSMILES>
CCOC(=O)C1=C(NC(=O)CSC2=NN=C(CNC(=O)C3=CC=CC(C)=C3)N2CC4=CC=CC=C4)SC5=C1CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.092

>  <W2 Pf proliferation inhibition EC50 uM>
>1.456

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>13.96

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-106
  Mrv1591402191617072D          

 35 37  0  0  0  0            999 V2000
   -7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  2  0  0  0  0
 17 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  CHG  2  27   1  28  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-106

>  <JC_XSMILES>
CCCCC1=CC=C(C=C1)C(=O)NCCCN(C(=O)NC2=CC=C(C=C2)[N+]([O-])=O)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.213

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.685

>  <Powder data?>
No

>  <IFI value>
0.020833333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1061
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -2.7512   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -3.7741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -6.2491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3693   -6.7340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6242   -7.5187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4492   -7.5187    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7041   -6.7340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  2 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 14 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1061

>  <JC_XSMILES>
O=C(NCC1=CC=CC=C1)C2=CN=C(NCCCN3C=CN=C3)N=C2NCC4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3113

>  <W2 Pf proliferation inhibition EC50 uM>
1.039

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.029126214

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1062
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9234    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481    0.0548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612   -0.4973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -0.0848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3294   -0.4203    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042    0.7222    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1903    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9234    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9234    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9234    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1728    3.6716    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  4  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 14 19  4  0  0  0  0
 12 20  4  0  0  0  0
 20 21  2  0  0  0  0
 20 22  4  0  0  0  0
 10 22  4  0  0  0  0
 22 23  1  0  0  0  0
  6 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1062

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N=c2sc(=CC3=CC=C(I)O3)c(=O)n2C1C4=CC=CC=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
1.331

>  <W2 Pf proliferation inhibition EC50 uM>
0.57

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>5.49

>  <Powder data?>
No

>  <IFI value>
0.048192771

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1066
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  2  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 14 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 25 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1066

>  <JC_XSMILES>
COC1=CC=CC(OC)=C1C(=O)NN2C(=O)C3=CC=CC=C3N=C2C4=CC=CC(C)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.034

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1068
  Mrv1591402191617072D          

 51 56  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 10 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  8 24  4  0  0  0  0
 23 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
 31 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 35 40  4  0  0  0  0
  5 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
  3 43  4  0  0  0  0
 43 44  1  0  0  0  0
 44 45  1  0  0  0  0
 45 46  1  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 48 49  4  0  0  0  0
 49 50  4  0  0  0  0
 50 51  4  0  0  0  0
 46 51  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1068

>  <JC_XSMILES>
COC1=CC(CNC2=CC(OCCOC3=CC=C(Cl)C=C3)=CC(=C2)C(=O)NC4CCN(CC4)CC5=CC=CC=C5)=CC=C1OCC6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.902

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>12.12

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-107
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
  6 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-107

>  <JC_XSMILES>
COC1=CN=C(N=C1NC(C)C)C2=CC=CC=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.712

>  <W2 Pf proliferation inhibition EC50 uM>
1.1

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.499

>  <Powder data?>
Yes

>  <IFI value>
0.025

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1070
  Mrv1591402191617072D          

 19 19  0  0  0  0            999 V2000
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
  7 17  4  0  0  0  0
 17 18  4  0  0  0  0
  3 18  4  0  0  0  0
 18 19  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1070

>  <JC_XSMILES>
CCC1=C(C)N=C(SCC(=O)NNC(C)=O)N=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.031

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.016129032

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1071
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    0.6411   -3.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -3.0146    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -3.0146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -3.8396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
 10  5  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1071

>  <JC_XSMILES>
COC1=CC(=CC=C1O)C=NNC2=NC3=NON=C3N=C2NC4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.031

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1072
  Mrv1591402191617072D          

 22 24  0  0  1  0            999 V2000
    1.9132    1.7706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7365    1.7181    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1028    0.9789    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.9277    0.9881    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4493    0.3489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2349    0.6008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8459    0.0465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6314    0.2985    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6713   -0.7598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2823   -1.3142    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1077   -2.1205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8857   -1.0118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2747   -0.4575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5354   -0.8237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5447   -1.6487    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7882   -0.4741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0847   -0.9051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4574   -0.3693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7732    0.3929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5956    0.3281    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.6552   -0.5619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4209   -1.3529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  1  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  9 12  4  0  0  0  0
 12 13  4  0  0  0  0
  5 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 20 19  1  0  0  0  0
  3 20  1  0  0  0  0
 20 16  1  1  0  0  0
 18 21  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1072

>  <JC_XSMILES>
CO[C@H]1NC2=CC(O)=C(OC)C=C2C(=O)N3CC(\C[C@@H]13)=C/C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.027

>  <W2 Pf proliferation inhibition EC50 uM>
0.875

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.49

>  <Powder data?>
No

>  <IFI value>
0.285714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1074
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  6 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 18 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 35 36  4  0  0  0  0
 27 36  4  0  0  0  0
 36 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1074

>  <JC_XSMILES>
CCOC1=CC(=CC=C1OCC2=CC=CC=C2)C(NC3=CC(C)=CC=N3)C4=CC=C5C=CC=NC5=C4O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.339

>  <W2 Pf proliferation inhibition EC50 uM>
1.029

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1078
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309    1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9441    2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7511    2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1636    1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6116    1.3144    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  3 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  4  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 11 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  1  0  0  0  0
 21 26  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   7
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1078

>  <JC_XSMILES>
O=C1C(SC2=NNC=N2)=CC(=NS(=O)(=O)C3=CC=CS3)C4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
1.526

>  <W2 Pf proliferation inhibition EC50 uM>
0.707

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.91

>  <Powder data?>
Yes

>  <IFI value>
0.25

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1079
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
 11 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  8 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 21 26  4  0  0  0  0
  5 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1079

>  <JC_XSMILES>
CC(=O)OC1=CC=C(C(=O)C(C(C)=O)C2=CC=CC=C2)C(OC(C)=O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.386

>  <W2 Pf proliferation inhibition EC50 uM>
>1.022

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-108
  Mrv1591402191617072D          

 35 36  0  0  0  0            999 V2000
    5.6091    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    4.8884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    5.7134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9880    2.8972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    3.6509    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.1759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    2.4134    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4657    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9910   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7360   -2.5686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9110   -2.5686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6561   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8715   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2584   -2.0811    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7000   -0.7221    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    2.8259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4670    3.2384    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  4  0  0  0
 13 14  2  0  0  0  0
 14 15  1  4  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  2 25  1  0  0  0  0
 16 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 26 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
 11 34  1  0  0  0  0
 34 35  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-108

>  <JC_XSMILES>
CC1CC(C)CC(C)C(O)C(=CC=CCC(OC(=O)CC(O)C(C)C1)C2CCCC2C(O)=O)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0437

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.85

>  <Powder data?>
No

>  <IFI value>
0.257575758

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1084
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -8.2500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -10.7250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  2  0  0  0  0
 21 23  4  0  0  0  0
 13 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1084

>  <JC_XSMILES>
CCCNC(=O)CCCCCSC1=NC2=CC=CC=C2C(=O)N1C3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.78

>  <W2 Pf proliferation inhibition EC50 uM>
>1.175

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.52

>  <Powder data?>
No

>  <IFI value>
0.009259259

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1086
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572    1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7322    3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  4 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1086

>  <JC_XSMILES>
CC(C)N(C\C(C)=C\C1=CC=CC=C1)C(=O)C2=CC=C(C=C2)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2171

>  <W2 Pf proliferation inhibition EC50 uM>
0.535

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>5.25

>  <Powder data?>
No

>  <IFI value>
0.021505376

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1087
  Mrv1591402191617072D          

 36 41  0  0  0  0            999 V2000
    0.3230    5.6317    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2446    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2446    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8533    6.5502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0409    6.6935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2413    7.4688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2890    8.1007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0068    8.8760    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.1015    7.9575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3836    7.1822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 27  1  0  0  0  0
 24 28  1  0  0  0  0
 20 28  1  0  0  0  0
 28 29  2  0  0  0  0
  2 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 35 36  4  0  0  0  0
 30 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1087

>  <JC_XSMILES>
OC1(CCN(CC1)C(=O)C2CCN(CC2)C3=CC=CC4=C3C(=O)N(C5CC5)C4=O)C6=CC=C(Cl)C=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.019

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.088235294

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1088
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
   -2.0647    0.0552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5246   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -0.8802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -1.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -1.3480    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    0.0552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9058   -0.1007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3657    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444    0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9845    0.9907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.7702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0957    1.9262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358    1.3025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459    1.4584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    2.2380    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860    0.8348    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961    0.9907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662    1.7702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763    1.9262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164    1.3025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2265    1.4584    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362    0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261   -1.9716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -1.8157    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -2.7512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961   -3.3748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261   -4.1543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -4.3103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -3.6866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459   -2.9071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459   -5.0898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -5.8694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6663   -4.8198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2254   -5.3599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
  7 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 34 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  1  0  0  0  0
 37 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1088

>  <JC_XSMILES>
CCCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=C(F)C=C3)C(=O)C4=CC=C(C=C4)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.795

>  <W2 Pf proliferation inhibition EC50 uM>
1.019

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.038834951

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-109
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -4.9504   -1.8941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2830   -1.4092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3692   -0.5887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7018   -0.1038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9481   -0.4393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2807    0.0456    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8619   -1.2598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5293   -1.7447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1082   -1.5954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0219   -2.4158    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4407   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4407   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6561   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6561   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  13
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  24
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-109

>  <JC_XSMILES>
CC1=CC=C(O)C(=C1)C(=O)C2=CNC(=C2)C3=NC4=CC=CC=C4N3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.878

>  <W2 Pf proliferation inhibition EC50 uM>
2.472

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.65

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1090
  Mrv1591402191617072D          

 44 49  0  0  0  0            999 V2000
    3.1566    3.2550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8761    2.4791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0639    2.3342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4077    1.8483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1271    1.0724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5899    0.3894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0833   -0.2617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3124   -1.0543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7405   -1.6489    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1133   -1.2522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6852   -0.6575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4861   -0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7151   -1.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1433   -2.2427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3424   -2.0448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3075    0.0188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3346    0.8434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6834    1.3499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8605    1.2907    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7965    2.1672    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1453    2.6737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2585    3.4909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6073    3.9975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7204    4.8147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4847    5.1253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1358    4.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0227    3.8016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2804   -0.8057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2534   -1.6303    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4879   -1.0348    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0251   -0.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2079   -0.2387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1028    0.5256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4038    1.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0932    1.9410    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.2210    1.0637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5317    0.2994    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4145    0.3624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8502    1.0629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6747    1.0359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0636    0.3082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8881    0.2812    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.6278   -0.3923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8033   -0.3652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  7 16  1  0  0  0  0
 16 17  1  0  0  0  0
  5 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 16 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 16 37  1  0  0  0  0
 31 37  4  0  0  0  0
  6 38  1  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  1  0  0  0  0
 41 43  4  0  0  0  0
 43 44  4  0  0  0  0
 38 44  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1090

>  <JC_XSMILES>
CC(C)CC1C(C(C(=O)C2=CC=CC=C2)C4(N1C(=O)NCC3=CC=CC=C3)C(=O)NC5=CC=C(Br)C=C45)C6=CC=C(Cl)C=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.775

>  <W2 Pf proliferation inhibition EC50 uM>
>1.018

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.036363636

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1091
  Mrv1591402191617072D          

 41 44  0  0  0  0            999 V2000
   -7.5572   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7322   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  5 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 29 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 36 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1091

>  <JC_XSMILES>
CS(=O)(=O)N(CCC1=CC=CC=C1)CC(O)CN2CCC(CC2)CNC(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.527

>  <W2 Pf proliferation inhibition EC50 uM>
1.017

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.029126214

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1092
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    7.5125    2.0072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7056    2.1788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1535    1.5657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3466    1.7372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7945    1.1241    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9876    1.2956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4355    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6285    0.8541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9256    2.2518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7326    2.0803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6904   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5154   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404    1.1740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 15 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1092

>  <JC_XSMILES>
CCCCOC1=CC=C(C=C1)C(=O)NC2=C3CSCC3=NN2C4=CC=C(C)C=C4C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.515

>  <W2 Pf proliferation inhibition EC50 uM>
1.017

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1095
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 16 22  4  0  0  0  0
 14 23  4  0  0  0  0
 23 24  2  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 11 26  4  0  0  0  0
 26 27  4  0  0  0  0
  8 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1095

>  <JC_XSMILES>
CCN(CC)C(=O)C1=CC=C2C(=O)N(CC3=CC=CC(Br)=C3)C(=S)NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.016

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1096
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    2.3522    0.3352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8825    1.2537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    0.0940    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    0.0940    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6534   -0.7137    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  2  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 16  4  0  0  0  0
  5 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1096

>  <JC_XSMILES>
CC1(C)CC2=C(CO1)SC(NC(=O)CCl)=C2C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
2.037

>  <W2 Pf proliferation inhibition EC50 uM>
2.085

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.53

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1097
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    5.9420   -3.7511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6565   -4.1636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6565   -4.9886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3709   -3.7511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3709   -2.9261    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.0854   -4.1636    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7999   -3.7511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5144   -4.1636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2288   -3.7511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2288   -2.9261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9433   -2.5136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6578   -2.9261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3722   -2.5136    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.6578   -3.7511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9433   -4.1636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3722   -4.1636    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.1259   -3.8280    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.6780   -4.4411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.5030   -4.4411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.9155   -5.1556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.5030   -5.8701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6780   -5.8701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2655   -5.1556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4585   -4.9841    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1097

>  <JC_XSMILES>
CC(=C)C(=O)OCCC1=CC=C(O)C(=C1)N2N=C3C=CC=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.015

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1098
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  8 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
M  CHG  1  12   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1098

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=CC(C)=[N+](C)C(=C2)C3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3127

>  <W2 Pf proliferation inhibition EC50 uM>
0.763

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.52

>  <Powder data?>
Yes

>  <IFI value>
0.106060606

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1099
  Mrv1591402191617072D          

 27 30  0  0  1  0            999 V2000
    2.5044   -4.5981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4449   -3.7753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7025   -3.4154    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1277   -3.3123    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0682   -2.4895    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8389   -1.6970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5218   -1.2340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1731   -1.7404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9852   -1.5952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2656   -0.8193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0777   -0.6741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6095   -1.3048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4216   -1.1597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9534   -1.7904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7655   -1.6452    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6731   -2.5663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8609   -2.7115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3291   -2.0808    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.0488   -2.8567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5170   -2.2259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2367   -3.0019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4246   -3.1470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8928   -2.5163    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5329   -3.2587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2561   -2.6347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7243   -2.0039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5732   -3.0976    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  5  4  1  6  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 18 17  1  0  0  0  0
 18 12  1  0  0  0  0
 18 19  1  1  0  0  0
 18 20  1  0  0  0  0
  9 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 23 22  1  0  0  0  0
 23  5  1  0  0  0  0
 23  8  1  0  0  0  0
 23 24  1  1  0  0  0
  5 25  1  1  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1099

>  <JC_XSMILES>
CC(=O)O[C@@]1(CCC2C3C=CC4=CC(=O)CC[C@]4(C)C3CC[C@]12C)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.213

>  <W2 Pf proliferation inhibition EC50 uM>
1.014

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.023255814

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-110
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6658    2.8193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    3.4867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3963    3.2318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2712    3.7167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3963    2.4068    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4487   -4.0704    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1937   -4.8550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3687   -4.8550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1138   -4.0704    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 10 15  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 24 28  4  0  0  0  0
 19 29  4  0  0  0  0
 29 30  4  0  0  0  0
 16 30  4  0  0  0  0
 30 31  4  0  0  0  0
  5 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-110

>  <JC_XSMILES>
COC(=O)C1=C(NC(=O)C2=CC=C(C)S2)C3=CC=C(CN(C)CC4=NC=CS4)N=C3S1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.33

>  <W2 Pf proliferation inhibition EC50 uM>
1.149

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>2.843

>  <Powder data?>
No

>  <IFI value>
0.017094017

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1100
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -1.5269   -0.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9966    0.3627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  2  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
  7 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1100

>  <JC_XSMILES>
CC1(C)CC(=O)C2=C(C1)NC(=O)CC2C3=CC=C(C=C3)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.012

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.090909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1101
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -6.0166   -0.0674    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -5.1961    0.0188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8605    0.7725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0401    0.8587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5551    0.1913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8907   -0.5624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7112   -0.6486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0467   -1.4023    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.7346    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3221    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5152    0.8205    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1826   -0.3356    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 16 25  4  0  0  0  0
 25 26  1  0  0  0  0
 14 27  1  0  0  0  0
 27 28  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1101

>  <JC_XSMILES>
ClC1=CC=C(C=C1Cl)C2=CSC(=N2)\C(=C\C3=CC4=CC=CC=C4N=C3Cl)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.011

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1103
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    4.8946    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.1759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -3.2361    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4131   -0.7221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3715   -0.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5430    0.3398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0701    0.8918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8547    0.6369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0262   -0.1701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.1759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
  8 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  6 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
  3 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1103

>  <JC_XSMILES>
COC1=CC=C(\C=C2/SC(=O)NC2=NC3=CC=CC=C3)C(OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.1

>  <W2 Pf proliferation inhibition EC50 uM>
1.011

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1104
  Mrv1591402191617072D          

 36 38  0  0  0  0            999 V2000
   -2.0647    0.0552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5246   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -0.8802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -1.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -1.3480    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    0.0552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9058   -0.1007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3657    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444    0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9845    0.9907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7946    0.8348    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.7702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0957    1.9262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358    1.3025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459    1.4584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    2.2380    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860    0.8348    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961    0.9907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362    0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261   -1.9716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -1.8157    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -2.7512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961   -3.3748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261   -4.1543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -4.3103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -3.6866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459   -2.9071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459   -5.0898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -5.8694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6663   -4.8198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2254   -5.3599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  2  0  0  0  0
 20 22  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  7 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 30 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
 33 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1104

>  <JC_XSMILES>
CCCCCCN(C(CC)C1=NC2=CC(Cl)=CC=C2C(=O)N1CC)C(=O)C3=CC=C(C=C3)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.954

>  <W2 Pf proliferation inhibition EC50 uM>
1.01

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1107
  Mrv1591402191617072D          

 35 37  0  0  0  0            999 V2000
   -0.7145   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -0.5230    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9355   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230   -1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7605   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1730   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8375   -2.7056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4506   -3.2577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1650   -2.8452    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9935   -2.0382    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5455   -1.4251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3525   -1.5966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9045   -0.9835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6496   -0.1989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8426   -0.0274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5877    0.7572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2906   -0.6405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3643   -4.0782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2781   -4.8986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1848   -4.1644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5438   -3.9919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020    0.9059    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5395    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9520   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7770   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1895    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7770    0.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9520    0.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1895    1.6204    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -4.0145    1.6204    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.7770    2.3349    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 11 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  4 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  2  0  0  0  0
M  CHG  2  33   1  34  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1107

>  <JC_XSMILES>
CCCN(CC(=O)NC1=CC(=NN1C2=CC=CC(C)=C2)C(C)(C)C)C(=O)C3=CC=CC(=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.629

>  <W2 Pf proliferation inhibition EC50 uM>
1.009

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.036036036

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1109
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4467   -3.6020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717   -2.1730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  2  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  6 12  4  0  0  0  0
 12 13  4  0  0  0  0
  3 13  4  0  0  0  0
 10 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 24 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1109

>  <JC_XSMILES>
COC1=CC=C2OC(=O)C(=CC2=C1)C(=O)N(C)C3=CC=C(C=C3)S(N)(=O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.008

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-111
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8810   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0525   -1.8980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8372   -1.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4502   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2787   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4941   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2349   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0195   -1.6852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4898   -2.7248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9799   -1.1555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1946   -1.8980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0339   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8186   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9901   -2.4922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7747   -2.2373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3770   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5924   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 12 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-111

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(=O)N2C(CSC2C3=CC=C(C=C3)C(C)(C)C)C(=O)NC4=CC=C(C)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.036

>  <W2 Pf proliferation inhibition EC50 uM>
1.167

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>2.97

>  <Powder data?>
No

>  <IFI value>
0.021978022

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1111
  Mrv1591402191617072D          

 47 49  0  0  0  0            999 V2000
   -3.5724    2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2704    1.7605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4454    3.1895    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -3.1895    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -1.7605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684   -3.7125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184   -3.7125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020    0.5230    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    1.9520    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  2  0  0  0  0
 15 14  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 16 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 13 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 11 30  4  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 31 38  1  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 38 43  4  0  0  0  0
  8 44  1  0  0  0  0
 44 45  1  0  0  0  0
 44 46  1  0  0  0  0
 44 47  1  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  28
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1111

>  <JC_XSMILES>
FC(F)(F)C(=O)CC(=NNC1=NC(NN=C(CC(=O)C(F)(F)F)C(F)(F)F)=NC(=N1)N(C2=CC=CC=C2)C3=CC=CC=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.67

>  <W2 Pf proliferation inhibition EC50 uM>
1.007

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1112
  Mrv1591402191617072D          

 86 86  0  0  1  0            999 V2000
    9.7835    5.9619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9467    5.1532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7287    4.8903    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   11.3474    5.4360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8920    4.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6740    3.8186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8372    3.0099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2185    2.4642    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.6192    2.7470    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.2916    3.2251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9540    2.7334    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   14.7412    2.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6911    1.9514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8661    1.9598    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   12.3744    1.2974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5548    1.3920    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.7022    0.5403    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.2105   -0.1221    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   11.3909   -0.0275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8992   -0.6900    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   11.2271   -1.4470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0797   -0.5954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5879   -1.2578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9158   -2.0149    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7684   -1.1632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2767   -1.8256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6045   -2.5827    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4571   -1.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9654   -2.3934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5383   -0.8792    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3579   -0.9738    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.0466   -1.5417    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.3744   -2.2987    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   13.1940   -2.3933    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   13.5218   -3.1504    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.6857   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.8655   -0.9257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.5053   -1.8255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8827   -2.9612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0632   -2.8666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.2106   -3.7182    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.7188   -4.3807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0564   -3.8890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3813   -4.8724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2271   -5.0431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4076   -4.9485    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.5549   -5.8002    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.0632   -6.4626    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   10.2437   -6.3680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7519   -7.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9324   -6.9358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0798   -7.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3911   -7.2197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2106   -7.3143    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.8993   -7.8822    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.2272   -8.6392    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   12.0467   -8.7338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5384   -8.0714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7182   -7.2662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3580   -8.1660    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7354   -9.3017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9159   -9.2070    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.0633  -10.0587    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.5716  -10.7212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9091  -10.2295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2340  -11.2129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0798  -11.3836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2603  -11.2890    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4077  -12.1407    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.9159  -12.8031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2535  -12.3114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5784  -13.2949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4242  -13.4656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6047  -13.3710    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7521  -14.2227    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2603  -14.8851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5882  -15.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0965  -16.3046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2769  -16.2100    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.4243  -17.0617    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.9326  -17.7241    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    8.1130  -17.6295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2604  -18.4812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7687  -19.1436    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0965  -19.9007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9491  -19.0490    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  0  0  0  0
  3  4  1  6  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 11 10  1  0  0  0  0
 11 12  1  1  0  0  0
 11 13  1  0  0  0  0
 14 13  1  0  0  0  0
 14  9  1  0  0  0  0
 14 15  1  1  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 18 17  1  6  0  0  0
 18 19  1  0  0  0  0
 20 19  1  0  0  0  0
 20 21  1  6  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 18 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 33 32  1  1  0  0  0
 33 34  1  0  0  0  0
 34 35  1  1  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 36 38  1  0  0  0  0
 33 39  1  0  0  0  0
 39 40  2  0  0  0  0
 39 41  1  0  0  0  0
 41 42  1  0  0  0  0
 42 43  1  0  0  0  0
 42 44  1  0  0  0  0
 42 45  1  0  0  0  0
 45 46  2  0  0  0  0
 45 47  1  0  0  0  0
 48 47  1  6  0  0  0
 48 49  1  0  0  0  0
 49 50  1  0  0  0  0
 50 51  1  0  0  0  0
 50 52  1  0  0  0  0
 48 53  1  0  0  0  0
 53 54  2  0  0  0  0
 53 55  1  0  0  0  0
 56 55  1  1  0  0  0
 56 57  1  0  0  0  0
 57 58  1  0  0  0  0
 58 59  1  0  0  0  0
 58 60  1  0  0  0  0
 56 61  1  0  0  0  0
 61 62  2  0  0  0  0
 61 63  1  0  0  0  0
 63 64  1  0  0  0  0
 64 65  1  0  0  0  0
 64 66  1  0  0  0  0
 64 67  1  0  0  0  0
 67 68  2  0  0  0  0
 67 69  1  0  0  0  0
 69 70  1  0  0  0  0
 70 71  1  0  0  0  0
 70 72  1  0  0  0  0
 70 73  1  0  0  0  0
 73 74  2  0  0  0  0
 73 75  1  0  0  0  0
 75 76  1  0  0  0  0
 76 77  1  0  0  0  0
 77 78  1  0  0  0  0
 78 79  2  0  0  0  0
 78 80  1  0  0  0  0
 81 80  1  0  0  0  0
 81 82  1  6  0  0  0
 81 83  1  0  0  0  0
 83 84  1  0  0  0  0
 84 85  1  0  0  0  0
 84 86  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1112

>  <JC_XSMILES>
CC[C@H](C)\C=C\C(=O)N1C[C@@H](C)C[C@H]1C(=O)N[C@@H](C[C@H](C)CC(O)CC(=O)CC)C(=O)N[C@@H]([C@H](O)C(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NCCC(=O)N[C@@H](C)CN(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1935

>  <W2 Pf proliferation inhibition EC50 uM>
0.651

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.47

>  <Powder data?>
No

>  <IFI value>
0.120689655

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1113
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
   -3.8795   -3.0366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1650   -3.4491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4506   -3.0366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7361   -3.4491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0216   -3.0366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0216   -2.2116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3072   -3.4491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3072   -4.2741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4073   -3.0366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1610   -3.3722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3325   -4.1792    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7130   -2.7591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3005   -2.0446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4936   -2.2161    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7130   -1.3301    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5380   -1.3301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9505   -2.0446    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7755   -2.0446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1880   -2.7591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7755   -3.4736    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0130   -2.7591    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4255   -3.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2505   -3.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4255   -2.0446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2505   -2.0446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5380   -2.7591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9505   -3.4736    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 17 26  4  0  0  0  0
 12 26  4  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1113

>  <JC_XSMILES>
CCCCN(C)C(=O)C1=C(C)C2=C(S1)N=CN(CC(=O)N(CC)CC)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.006

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1116
  Mrv1591402191617072D          

 56 66  0  0  0  0            999 V2000
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 24 36  1  0  0  0  0
 36 37  2  0  0  0  0
 35 38  4  0  0  0  0
 27 38  4  0  0  0  0
 31 38  4  0  0  0  0
 17 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 10 44  4  0  0  0  0
 39 44  4  0  0  0  0
  3 45  1  0  0  0  0
 45 46  2  0  0  0  0
 45 47  1  0  0  0  0
 47 48  4  0  0  0  0
 48 49  4  0  0  0  0
 49 50  4  0  0  0  0
 50 51  4  0  0  0  0
 51 52  4  0  0  0  0
 52 53  4  0  0  0  0
  2 53  1  0  0  0  0
 48 53  4  0  0  0  0
 49 54  4  0  0  0  0
 54 55  4  0  0  0  0
 55 56  4  0  0  0  0
 47 56  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1116

>  <JC_XSMILES>
O=C1N(C2=CC=C(C=C2)C3=C4C=CC=CC4=C(C5=CC=C(C=C5)N6C(=O)C7=CC=CC8=CC=CC(C6=O)=C78)C9=CC=CC=C39)C(=O)C%10=C%11C(C=CC=C1%11)=CC=C%10

>  <PF proliferation inhibition 3D7 EC50 uM>
1.053

>  <W2 Pf proliferation inhibition EC50 uM>
1.003

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1117
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    3.8795   -3.8616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5940   -3.4491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5940   -2.6241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3084   -3.8616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0229   -3.4491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7374   -3.8616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4519   -3.4491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4519   -2.6241    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.1663   -3.8616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9200   -3.5261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0915   -2.7191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4720   -4.1392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2970   -4.1392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7095   -4.8536    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.2970   -5.5681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7095   -6.2826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4720   -5.5681    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0595   -4.8536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2526   -4.6821    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.7095   -3.4247    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.2970   -2.7102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7095   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5345   -1.9957    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.9470   -1.2813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9470   -2.7102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5345   -3.4247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  4  0  0  0  0
 13 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 20 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1117

>  <JC_XSMILES>
CN(C)CCNC(=O)C1=C(C)C2=C(N=C(C)N=C2S1)N3CCN(C)CC3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.598

>  <W2 Pf proliferation inhibition EC50 uM>
>1.001

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.011235955

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1118
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
   -3.0091   -0.1648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2021    0.0067    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6501   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9050   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3530   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5460   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1215   -2.3175    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7889   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5340   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0860   -0.4349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8930   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1479   -1.3910    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9549   -1.5625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5959   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8508   -2.7887    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2910   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8431   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  2  0  0  0  0
  9 16  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  4  0  0  0  0
  3 17  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   7
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1118

>  <JC_XSMILES>
COC1=CC=C2NC3=C(N=CN(C)C3=O)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.413

>  <W2 Pf proliferation inhibition EC50 uM>
1.001

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1119
  Mrv1591402191617072D          

 19 19  0  0  0  0            999 V2000
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5395    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  2 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1119

>  <JC_XSMILES>
CN(CC(=O)NC(C)(C)C)S(=O)(=O)C1=CC=CC=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1120
  Mrv1591402191617072D          

 19 22  0  0  0  0            999 V2000
    0.1535   -1.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3658   -0.7389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3696   -1.1126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0798   -0.3224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0798    0.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8152    0.7986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8778    1.6633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5508    0.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5508   -0.3224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1013   -1.1126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8152   -0.6960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8151   -1.5210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5296   -1.9335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5296   -2.7584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8151   -3.1708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1007   -2.7583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1008   -1.9334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3658    0.0084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5964    0.1385    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  6  8  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2 10  1  0  0  0  0
  4 11  1  0  0  0  0
  9 10  1  0  0  0  0
  6 18  1  0  0  0  0
  9 11  1  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  2 18  1  0  0  0  0
  4  5  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1120

>  <JC_XSMILES>
CC12CN3CC(C)(CN(C1)C3C4=CC=CC=C4)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.18

>  <W2 Pf proliferation inhibition EC50 uM>
>10

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1121
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    0.7571    3.2564    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.6624    2.4369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3249    1.9451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2302    1.1256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4732    0.7978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1893    1.2895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0946    2.1091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3785   -0.0218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3785   -0.3496    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0410   -0.5135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9463   -1.3331    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6088   -1.8248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3658   -1.4970    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5141   -2.6444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1766   -3.1361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9337   -2.8083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0283   -1.9887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7854   -1.6609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4478   -2.1526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3532   -2.9722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0156   -3.4639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9210   -4.2835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1639   -4.6113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5015   -4.1196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7444   -4.4474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0819   -3.9556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3249   -4.2835    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6624   -3.7917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0946   -4.1196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7571   -3.6278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6624   -2.8083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0946   -2.4804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7571   -2.9722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 15 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 14 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1121

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C(=O)COC(=O)C2=C3CCCCCCCCCCC3=NC4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.18

>  <W2 Pf proliferation inhibition EC50 uM>
>10

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1123
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.1759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.1759    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1331   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8781   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0531   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7982   -1.7840    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4240   -1.2025    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6494   -1.2025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2621   -1.9310    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.9210   -0.8152    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.3778   -1.5899    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.1759    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
  7 15  1  0  0  0  0
  2 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
  6 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1123

>  <JC_XSMILES>
CN1C(=O)NC(C(C(=O)C2=CC=CS2)C1(O)C(F)(F)F)C3=CC=CN=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.18

>  <W2 Pf proliferation inhibition EC50 uM>
>10

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1124
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    4.7812    1.9354    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.0940    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3686    0.1410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1532    0.3960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1532    1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3686    1.4759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
  7 13  4  0  0  0  0
 13 14  4  0  0  0  0
  4 14  4  0  0  0  0
 10 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 22 26  4  0  0  0  0
 18 27  4  0  0  0  0
 27 28  4  0  0  0  0
 15 28  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1124

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C2C(=O)N(C(=O)C2=C1)C3=CC=C(OC(=O)C4=CC=CO4)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>10

>  <W2 Pf proliferation inhibition EC50 uM>
>10

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1125
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    4.7812    0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    2.7604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1937    2.6499    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3687    1.2210    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  2  0  0  0  0
  7  9  4  0  0  0  0
  2  9  4  0  0  0  0
  3 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 19 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1125

>  <JC_XSMILES>
CC1=C(C(=O)NC(=O)N1)S(=O)(=O)NC2=CC=C3OC(=NC3=C2)C4=CC=NC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>10

>  <W2 Pf proliferation inhibition EC50 uM>
>10

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1127
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -3.6791    2.7027    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6791    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8541    3.5277    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5041    3.5277    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6791    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3935    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3935    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6791    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6791    6.8277    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501    6.0027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    4.7652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    5.5902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041    3.0428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693    3.0428    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 23 27  4  0  0  0  0
 10 28  4  0  0  0  0
  5 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1127

>  <JC_XSMILES>
FC(F)(F)C1=CC=C(Cl)C(NC(=O)CN2CCN(CC2)C(=O)C3=CC=CO3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.04

>  <W2 Pf proliferation inhibition EC50 uM>
>10

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-113
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    2.5645    7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    3.2704    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 23 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-113

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2CCN(CC2)C3=NC=NC4=C3C(C)=C(S4)C(=O)NCC5=CC=CN=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.18

>  <W2 Pf proliferation inhibition EC50 uM>
>8.11

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.72

>  <Powder data?>
Yes

>  <IFI value>
0.01

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1130
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  9 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
  7 27  4  0  0  0  0
 27 28  4  0  0  0  0
  4 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1130

>  <JC_XSMILES>
CCOC1=CC=C2N=C3C=C(NC(=O)C4=CC=C(C)C=C4)C=CC3=C(N)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.187

>  <W2 Pf proliferation inhibition EC50 uM>
0.997

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1140
  Mrv1591402191617072D          

 48 54  0  0  0  0            999 V2000
   -8.4302   -1.6900    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -7.7157   -2.1025    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -7.7157   -2.9275    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0012   -1.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0012   -0.8650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2868   -0.4525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5723   -0.8650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5723   -1.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2868   -2.1025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2868   -2.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0012   -3.3400    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5723   -3.3400    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8578   -2.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8578   -2.1025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1434   -1.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4289   -2.1025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4289   -2.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1434   -3.3400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7144   -1.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6282   -0.8695    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9607   -2.0255    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.7812   -3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 19 27  4  0  0  0  0
 24 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  2  0  0  0  0
 35 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
 42 43  1  0  0  0  0
 43 44  1  0  0  0  0
 43 45  2  0  0  0  0
 33 46  4  0  0  0  0
 46 47  4  0  0  0  0
 30 47  4  0  0  0  0
 47 48  4  0  0  0  0
 28 48  4  0  0  0  0
M  CHG  4   1  -1   2   1  43   1  44  -1
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  29
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1140

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C3=NC4=CC=C(C=C4N3)C5=NC6=CC=C(NC(=O)C7=CC=CC=C7[N+]([O-])=O)C=C6N5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.987

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1146
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -2.1730    2.5559    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730    1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4585    1.3184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4586    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1731    0.0809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8875    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8875    1.3184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1731   -0.7441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8876   -1.1566    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4587   -1.1566    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4587   -1.9816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1732   -2.3941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8876   -1.9816    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.4282   -3.1787    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7442   -2.3942    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
   -0.0298   -2.8067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6847   -2.3942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3992   -2.8068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3991   -3.6318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6846   -4.0442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0298   -3.6317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1568   -3.1086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7443   -3.8231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1568   -4.5376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9818   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3943   -3.8230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9818   -3.1086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3317   -1.6797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7442   -0.9652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3316   -0.2508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4934   -0.2508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9058   -0.9653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4933   -1.6797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 15 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1146

>  <JC_XSMILES>
FC1=CC=C(C=C1)C(=O)NC(=C(Cl)Cl)[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.954

>  <W2 Pf proliferation inhibition EC50 uM>
0.171

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.739

>  <Powder data?>
Yes

>  <IFI value>
0.272727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1149
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 11 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
  9 29  4  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1149

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2N=C(C(=O)NCCC3=CCCCC3)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
7.22

>  <W2 Pf proliferation inhibition EC50 uM>
>9.81

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-115
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
  4 11  4  0  0  0  0
  2 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  2  0  0  0  0
 20 22  4  0  0  0  0
 12 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-115

>  <JC_XSMILES>
CC(NC1=CC=C(C)C(C)=C1)C2=NC3=CC=CC=C3C(=O)N2CCOC4CCCCO4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.799

>  <W2 Pf proliferation inhibition EC50 uM>
1.035

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>2.7

>  <Powder data?>
No

>  <IFI value>
0.019047619

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1152
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
   -6.9463  -10.3475    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1259  -10.2612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7903   -9.5075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9698   -9.4213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4849  -10.0888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8205  -10.8424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6409  -10.9287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6644  -10.0025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2519   -9.2880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4450   -9.4596    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3587  -10.2801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6442  -10.6926    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9298  -10.2801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9298   -9.4551    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2153  -10.6926    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4992  -10.2801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2136  -10.6926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9281  -10.2801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6426  -10.6926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3570  -10.2801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0715  -10.6926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7860  -10.2801    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5005  -10.6926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5005  -11.5176    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2149  -10.2801    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9294  -10.6926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6831  -10.3570    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.2351  -10.9701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8226  -11.6846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0156  -11.5130    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.0556  -10.8839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3911  -10.1302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2116  -10.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6966  -10.7114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5170  -10.6251    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.3610  -11.4651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5405  -11.5513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1124  -10.6156    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
 28 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 31 37  4  0  0  0  0
 11 38  4  0  0  0  0
  8 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1152

>  <JC_XSMILES>
FC1=CC=C(C=C1)C2=CSC(NC(=O)NCCCCCCNC(=O)NC3=NC(=CS3)C4=CC=C(F)C=C4)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
5.97

>  <W2 Pf proliferation inhibition EC50 uM>
5.06

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
51.61

>  <Powder data?>
Yes

>  <IFI value>
0.031746032

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1153
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8020    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6090    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0215    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4694   -0.3356    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8420    0.1913    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    8.3269    0.8587    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    8.1775   -0.5624    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 14 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 12 28  4  0  0  0  0
 28 29  4  0  0  0  0
  8 29  4  0  0  0  0
M  CHG  2  23   1  24  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1153

>  <JC_XSMILES>
CC1CCN(CC1)C2=CC(C)=C3C=C(NC(=O)C4=CC=C(O4)[N+]([O-])=O)C=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.66

>  <W2 Pf proliferation inhibition EC50 uM>
2.142

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.88

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1154
  Mrv1591402191617072D          

 20 23  0  0  0  0            999 V2000
    6.1857    5.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7732    4.4787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1088    3.7250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9528    4.3924    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
  2 10  4  0  0  0  0
  7 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  10
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  18
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1154

>  <JC_XSMILES>
CC1=NC2=CC=C(C=C2N1)C3=CC=C4N=C(C)NC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.093

>  <W2 Pf proliferation inhibition EC50 uM>
0.844

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.63

>  <Powder data?>
Yes

>  <IFI value>
0.030769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1156
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.6900   -3.4491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4045   -3.0366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190   -3.4491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190   -4.2741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8334   -3.0366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5479   -3.4491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2624   -3.0366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3486   -2.2161    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1556   -2.0446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5681   -1.3301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3931   -1.3301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8056   -2.0446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3931   -2.7591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5681   -2.7591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0161   -3.3722    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1876   -4.1792    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9722   -4.4341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5853   -3.8821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3699   -4.1370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5415   -4.9440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3261   -5.1989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9284   -5.4960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1437   -5.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
  7 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1156

>  <JC_XSMILES>
CCC(=O)NCC1=NC2=CC=CC=C2N1CC3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>9.76

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1157
  Mrv1591402191617072D          

 24 29  0  0  0  0            999 V2000
    1.5766   -4.4589    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7792   -4.6698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3285   -5.2852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4497   -5.0528    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2729   -5.2440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8221   -4.6285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0567   -4.8609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6490   -3.8219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0735   -3.6308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6228   -4.2463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9523   -3.8632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0734   -2.8059    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7878   -2.3934    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7877   -1.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0524   -1.9421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5018   -1.1519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5018   -0.4046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2372   -0.0309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9727   -0.4046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9727   -1.1519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7702   -1.3629    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2372   -1.5255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5233   -1.9421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7877   -0.8211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  4 10  1  0  0  0  0
  9 11  1  0  0  0  0
  2 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 17 18  1  0  0  0  0
 16 22  1  0  0  0  0
 14 23  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 18 24  1  0  0  0  0
 20 23  1  0  0  0  0
 19 20  1  0  0  0  0
 14 24  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1157

>  <JC_XSMILES>
NC12CC3CC(C1)CC(C3)(C2)SSC45CC6CC(CC(N)(C6)C4)C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2081

>  <W2 Pf proliferation inhibition EC50 uM>
0.1912

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.96

>  <Powder data?>
Yes

>  <IFI value>
0.081967213

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1158
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    1.9947   -0.0261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7091    0.3864    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4236   -0.0261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1381    0.3864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8525   -0.0261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8525   -0.8511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5670   -1.2636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2815   -0.8511    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9960   -1.2636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9960   -2.0886    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7104   -0.8511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4249   -1.2636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1394   -0.8511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2256   -0.0307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0326    0.1409    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4451   -0.5736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2521   -0.7451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5070   -1.5298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9550   -2.1428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1480   -1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8930   -1.1867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7104   -0.0261    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9960    0.3864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9960    1.2114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7104    1.6239    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.1801    2.2558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2407    2.2558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4249    1.2114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4249    0.3864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1381   -1.2636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4236   -0.8511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 16 21  4  0  0  0  0
 11 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  2  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 22 29  1  0  0  0  0
  6 30  4  0  0  0  0
 30 31  4  0  0  0  0
  3 31  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1158

>  <JC_XSMILES>
COC1=CC=C(CNC(=O)C(CC2=CNC3=CC=CC=C23)N4CCS(=O)(=O)CC4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.851

>  <W2 Pf proliferation inhibition EC50 uM>
0.784

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.04

>  <Powder data?>
No

>  <IFI value>
0.012820513

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1161
  Mrv1591402191617072D          

 34 39  0  0  0  0            999 V2000
    9.1883    1.2558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1595    2.0803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9765    1.9654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3525    1.9087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8005    2.5218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0554    3.3064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8624    3.4780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4144    2.8649    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.3880    3.7914    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7206    3.3064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9755    2.5218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4235    1.9087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6784    1.1241    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6165    2.0803    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0645    1.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435    1.9817    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6545    1.1404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1336    1.8501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3615    2.8649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9136    3.4780    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  2  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  5 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  2  0  0  0  0
 21 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 28 31  1  0  0  0  0
 24 31  1  0  0  0  0
 25 32  4  0  0  0  0
 20 32  4  0  0  0  0
 14 33  4  0  0  0  0
 33 34  4  0  0  0  0
 10 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1161

>  <JC_XSMILES>
CC1(C)CC2=C(CS1)OC3=C2C(=N)N(CCN4C=NC5=C(C4=N)C6=C(CSC(C)(C)C6)O5)C=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
9.74

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1162
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
   -5.5239   -4.9344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7392   -4.6794    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5677   -3.8725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7831   -3.6175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6116   -2.8106    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1636   -2.1975    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7511   -1.4830    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9441   -1.6545    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 11 17  1  0  0  0  0
 10 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
 20 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 18 31  4  0  0  0  0
 31 32  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  30
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1162

>  <JC_XSMILES>
COCCN1N=NN=C1C(N2CCC(O)CC2)C3=CC4=CC5=C(OCCO5)C=C4NC3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.974

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1166
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    5.3625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684    4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184    4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
  7 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1166

>  <JC_XSMILES>
NC1=NC(N)=C2C(OCC3=CC=C(C=C3)C(F)(F)F)=CC=CC2=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.782

>  <W2 Pf proliferation inhibition EC50 uM>
0.972

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076335878

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1169
  Mrv1591402191617072D          

 13 14  0  0  0  0            999 V2000
   -2.5474    0.0470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7224    0.0470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -0.6674    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3349    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.2549   -2.1195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2971   -2.7326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
  9 13  4  0  0  0  0
  4 13  4  0  0  0  0
M  CHG  1   5   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1169

>  <JC_XSMILES>
CCSC1=[N+](CC)C2=C(SC=C2)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.944

>  <W2 Pf proliferation inhibition EC50 uM>
0.833

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.58

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-117
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
  6 12  4  0  0  0  0
 12 13  4  0  0  0  0
  3 13  4  0  0  0  0
  8 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   7
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-117

>  <JC_XSMILES>
COC1=CC=C2N=C(C=C(O)C2=C1)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.411

>  <W2 Pf proliferation inhibition EC50 uM>
0.3142

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.835

>  <Powder data?>
Yes

>  <IFI value>
0.14159292

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1172
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    0.6434   -4.9612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3578   -5.3737    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3578   -6.1987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0723   -6.6112    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0723   -7.4362    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3578   -7.8487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3578   -8.6737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6434   -9.0862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0711   -8.6737    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6434   -9.9112    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0711  -10.3237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0711  -11.1487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7856  -11.5612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000  -11.1487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000  -10.3237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7856   -9.9112    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2145  -11.5612    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6270  -10.8467    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8020  -12.2757    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9290  -11.9737    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8673  -12.7964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4721  -13.3575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2879  -13.2346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7004  -12.5201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3990  -11.7521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6106  -11.5090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6434   -7.4362    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6434   -6.6112    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 20 26  1  0  0  0  0
  6 27  4  0  0  0  0
 27 28  4  0  0  0  0
  3 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1172

>  <JC_XSMILES>
COC1=CC=C(CC(=O)NC2=CC=C(C=C2)S(=O)(=O)N3CCCCCC3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
9.69

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1175
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
  7 24  4  0  0  0  0
 24 25  4  0  0  0  0
  4 25  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1175

>  <JC_XSMILES>
CCOC1=CC=C2N=C(C)C(CN(C)CC3=CC=CC=C3)=C(O)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.969

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1177
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -0.4752   -1.7084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 11 27  4  0  0  0  0
 14 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1177

>  <JC_XSMILES>
OC(CN1CCOCC1)CN2C=NC3=C(SCC4=CC=CC=C4)N=CN=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>9.67

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1183
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  2  0  0  0  0
 12 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  11
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1183

>  <JC_XSMILES>
OC(=O)C1=CC=CC(=C1)N2N=C(CC2=O)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>9.63

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.048192771

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1184
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -1.4289    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.7661    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.9812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.9812    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1184

>  <JC_XSMILES>
CC1=CC=CC=C1CSC2=CC=C(N=N2)C3=CC=CS3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.055

>  <W2 Pf proliferation inhibition EC50 uM>
0.963

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1188
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 17 23  4  0  0  0  0
 23 24  4  0  0  0  0
  9 24  4  0  0  0  0
 24 25  4  0  0  0  0
  6 25  4  0  0  0  0
 25 26  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1188

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C=C(OCC(C)C)C(OCC(C)C)=CC2=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.649

>  <W2 Pf proliferation inhibition EC50 uM>
0.958

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.006493506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-119
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
  3 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
  2 24  1  0  0  0  0
 24 25  2  0  0  0  0
M  CHG  2  13   1  14  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-119

>  <JC_XSMILES>
CC1=C(CC(=O)C2=CC=CC(=C2)[N+]([O-])=O)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.844

>  <W2 Pf proliferation inhibition EC50 uM>
1.722

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.69

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1194
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 16 25  4  0  0  0  0
 11 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1194

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CNC3CCCCC3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.842

>  <W2 Pf proliferation inhibition EC50 uM>
0.953

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017391304

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1195
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    2.3596   -3.4255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6451   -3.8380    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6451   -4.6630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3596   -5.0755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3596   -5.9005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6451   -6.3130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6451   -7.1380    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9307   -7.5505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9307   -5.9005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9307   -5.0755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2162   -6.3130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2162   -7.1380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4983   -7.5505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2127   -7.1380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9272   -7.5505    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2127   -6.3130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9272   -5.9005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6417   -6.3130    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3562   -5.9005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0107   -6.4028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8286   -6.2951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3308   -5.6406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2232   -4.8226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5686   -4.3204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7507   -4.4281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2485   -5.0826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4983   -5.9005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 19 26  1  0  0  0  0
 16 27  4  0  0  0  0
 11 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1195

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CNC3CCCCCCC3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.767

>  <W2 Pf proliferation inhibition EC50 uM>
0.952

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017241379

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1197
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    6.9755    2.5218    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4235    1.9087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6784    1.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0645    1.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435    1.9817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.0694    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1544   -0.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9614   -0.8867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5134   -0.2736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2585    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4515    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.6165    2.0803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  2  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
 16 27  4  0  0  0  0
 11 27  4  0  0  0  0
  6 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1197

>  <JC_XSMILES>
ClC1=CC=CC(CN2C=NC3=C(C2=O)C4=C(CC(CC4)N5CCCCC5)S3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.949

>  <W2 Pf proliferation inhibition EC50 uM>
2.643

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
27.79

>  <Powder data?>
Yes

>  <IFI value>
0.01754386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1198
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 12 21  4  0  0  0  0
  7 21  4  0  0  0  0
  5 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
  2 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1198

>  <JC_XSMILES>
CC1=CC=C(NC2=CC(C)=NC(NCC3=CC=CC=C3)=N2)C(C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3062

>  <W2 Pf proliferation inhibition EC50 uM>
0.619

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.51

>  <Powder data?>
Yes

>  <IFI value>
0.104477612

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-120
  Mrv1591402191617072D          

 33 38  0  0  0  0            999 V2000
    6.5473    7.9083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9953    7.2952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2502    6.5105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6982    5.8974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9531    5.1128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4011    4.4997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5941    4.6713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0421    4.0582    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2970    3.2735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1040    3.1020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6560    3.7151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4630    3.5436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7180    2.7590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5249    2.5874    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.1659    2.1459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3589    2.3174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2351    4.2297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9802    5.0143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2265    5.3499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3127    6.1704    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1197    6.3419    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5322    5.6274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3392    5.4559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8912    6.0690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5120    4.9374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5120    4.1124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7976    3.6999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0831    4.1124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7015    3.8574    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1864    4.5249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7015    5.1923    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0831    4.9374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7976    5.3499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
  8 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 22 23  4  0  0  0  0
  7 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
 19 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 28 32  4  0  0  0  0
 32 33  4  0  0  0  0
 25 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-120

>  <JC_XSMILES>
CCOC1=CC=C2N(CC3=CC=C(Cl)C=C3)C=C4C(=NN=C4C2=C1)C5=CC=C6OCOC6=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
8.39

>  <W2 Pf proliferation inhibition EC50 uM>
4.98

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.56

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1200
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  7 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 14 24  4  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1200

>  <JC_XSMILES>
COCC(=O)NC(C1=CC=CC=C1)C2=CC(Cl)=C3C=CC=NC3=C2O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.047

>  <W2 Pf proliferation inhibition EC50 uM>
0.95

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1201
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  9 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1201

>  <JC_XSMILES>
NC1=NC(N)=NC(=N1)C(C2=CC=CC=C2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.087

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>13.17

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1202
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  8 15  4  0  0  0  0
 15 16  2  0  0  0  0
  5 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  11
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  14
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1202

>  <JC_XSMILES>
CC1=CC=C(NC=C2C(=O)NC(=S)NC2=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>9.49

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1206
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -1.3333   -0.8607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8734   -1.4843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6033   -2.2639    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9535   -2.7316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7932   -2.4198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2531   -1.7961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5570   -1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0971   -1.3284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8271   -0.5488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0169   -0.3929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2531    0.3866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0632    0.5425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3333    1.3221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.4780    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4135    2.2575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7932    1.9457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0169    1.7898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2870    1.0103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0971    0.8543    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3672    0.0748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1773   -0.0811    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8271   -2.7316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2870   -3.3552    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6372   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9073   -3.6671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7174   -3.8230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9874   -4.6025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4473   -5.2262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6372   -5.0702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0971   -5.6939    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.3672   -4.2907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 12 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 10 21  4  0  0  0  0
 21 22  2  0  0  0  0
  8 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1206

>  <JC_XSMILES>
CCN(CC)CCN(CC1=CC2=CC(OC)=CC=C2NC1=O)C(=S)NC3=CC=CC(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.192

>  <W2 Pf proliferation inhibition EC50 uM>
2.187

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.06

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-121
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    1.4289   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    9.2411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    5.9411    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964    4.2187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315    2.7666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615    4.2187    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 11 16  4  0  0  0  0
  7 17  4  0  0  0  0
 17 18  4  0  0  0  0
  4 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-121

>  <JC_XSMILES>
CCOC1=CC=C(NC(=O)C2=CC=C(C)O2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
3.71

>  <W2 Pf proliferation inhibition EC50 uM>
4.43

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
13

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1210
  Mrv1591402191617072D          

 38 42  0  0  1  0            999 V2000
    4.9075    4.7694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4762    4.1718    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.2781    4.3655    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2430    3.3804    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.8118    2.7828    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5786    1.9914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7767    1.7977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5435    1.0063    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.1122    0.4087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7416    0.8126    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.1728    1.4102    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5084    0.0212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0771   -0.5764    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7036   -0.2891    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1319    0.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3358    0.2314    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.2249   -0.5861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8774   -1.0909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6408   -0.7783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2933   -1.2831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7517    0.0393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0992    0.5441    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2101    1.3616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4410    1.8693    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4961    2.6891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1168    1.6175    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.8021    1.8141    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0353    2.6055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4666    3.2031    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8372    2.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0704    3.5906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8724    3.7843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4411    3.1867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7670    0.8290    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.0046    0.5371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7942    1.5537    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0307    1.5426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3721    2.2626    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  2  3  1  1  0  0  0
  2  4  1  0  0  0  0
  4  5  1  6  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  0  0  0  0
  8  9  1  1  0  0  0
  8 10  1  0  0  0  0
 10 11  1  1  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 16 15  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 22 21  1  0  0  0  0
 16 22  1  0  0  0  0
 22 23  1  6  0  0  0
 24 23  1  0  0  0  0
 24 25  1  1  0  0  0
 26 25  1  1  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 30 28  1  4  0  0  0
 30 31  2  0  0  0  0
 32 31  1  4  0  0  0
 32 33  2  0  0  0  0
  4 33  1  0  0  0  0
 34 26  1  0  0  0  0
 34 16  1  0  0  0  0
 34 35  1  1  0  0  0
 34 36  1  0  0  0  0
 36 24  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 36 38  1  6  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1210

>  <JC_XSMILES>
C[C@@H](O)[C@@H]1OCC[C@@H](C)[C@H](O)C(=O)OC[C@]23CCC(C)=C[C@H]2O[C@@H]4C[C@@H](OC(=O)C=CC=C1)[C@@]3(C)[C@@]45CO5

>  <PF proliferation inhibition 3D7 EC50 uM>
<0.000572

>  <W2 Pf proliferation inhibition EC50 uM>
<0.000572

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.00604

>  <Powder data?>
No

>  <IFI value>
0.245283019

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1213
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4584   -4.9320    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2788   -5.0182    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6144   -4.2645    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4214   -4.0930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9734   -4.7061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7804   -4.5346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3324   -5.1477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0775   -5.9323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6295   -6.5454    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.2705   -6.1038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7185   -5.4907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 11 23  4  0  0  0  0
  7 23  4  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1213

>  <JC_XSMILES>
CCOC(=O)CN1C=NC2=C(N=NN2CC3=CC=C(F)C=C3)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.38

>  <W2 Pf proliferation inhibition EC50 uM>
0.1604

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>1.695

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1218
  Mrv1591402191617072D          

 37 39  0  0  0  0            999 V2000
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 15 26  4  0  0  0  0
 21 26  4  0  0  0  0
  8 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 34 37  4  0  0  0  0
 28 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1218

>  <JC_XSMILES>
CCCCNC(=O)N(CCCC(C)NC1=CC(OC)=CC2=CC=CN=C12)CC3=CC=C(OC)C(OC)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.265

>  <W2 Pf proliferation inhibition EC50 uM>
0.422

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>4.47

>  <Powder data?>
No

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-123
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    2.7512   -1.7116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.0215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -3.8062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8538   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0333   -4.3874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5484   -5.0548    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2721   -4.9686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7571   -5.6360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5775   -5.5498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9131   -4.7961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7336   -4.7098    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4282   -4.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6077   -4.2149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.0215    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
  5 16  4  0  0  0  0
  2 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-123

>  <JC_XSMILES>
NC1=NN=C(CCSC2=CC=C(Cl)C=C2)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1754

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>3.71

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1234
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
  8 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 19 26  4  0  0  0  0
  5 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 33 37  4  0  0  0  0
 37 38  4  0  0  0  0
 30 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1234

>  <JC_XSMILES>
CCCCN(C(C)C1=NC2=CC=CC=C2C(=O)N1C3=CC=C(F)C(Cl)=C3)C(=O)NC4=CC=C(OCC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.011

>  <W2 Pf proliferation inhibition EC50 uM>
0.935

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.117021277

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1239
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    1.3480   -5.4730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230   -5.4730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -5.4730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3480   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7605   -7.6164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5855   -7.6164    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9980   -8.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8230   -8.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2355   -7.6164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0605   -7.6164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4730   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2980   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7105   -7.6164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5355   -7.6164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9480   -8.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2980   -8.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4730   -8.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0605   -9.0454    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2355   -9.0454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8230   -9.7599    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9980   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5855   -6.1875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8230   -6.9020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2355   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8230   -5.4730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9980   -5.4730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5855   -4.7586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9980   -4.0441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8230   -4.0441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2355   -4.7586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  4  0  0  0  0
 19 20  4  0  0  0  0
 13 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  2  0  0  0  0
  9 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1239

>  <JC_XSMILES>
CCN(CC)CCCN(CC1=CC2=CC=C(OC)C=C2NC1=O)C(=S)NCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
3.91

>  <W2 Pf proliferation inhibition EC50 uM>
2.411

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
25.85

>  <Powder data?>
Yes

>  <IFI value>
0.034188034

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1243
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -8.9645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -7.5355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.9625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
  6 29  4  0  0  0  0
 29 30  4  0  0  0  0
  3 30  4  0  0  0  0
M  CHG  2  26   1  27  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1243

>  <JC_XSMILES>
COC1=CC=C(NS(=O)(=O)C2=CC=CC(=C2)C(=O)NC3=CC=CC=C3[N+]([O-])=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.13

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
44.45

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1248
  Mrv1591402191617072D          

 45 50  0  0  0  0            999 V2000
   12.6071   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8926   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1781   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4636   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4636   -1.2991    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7492   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7492    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4636    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0347    1.1759    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3202    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5356    1.0183    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.0507    0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2257    0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8132    1.0654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2257    1.7798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8132    2.4943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9882    2.4943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5757    1.7798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7507    1.7798    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3382    2.4943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5132    2.4943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1007    1.7798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2757    1.7798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8632    2.4943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2757    3.2088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8632    3.9232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2757    4.6377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1007    4.6377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5132    3.9232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1007    3.2088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9882    1.0654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5356   -0.3165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2807   -1.1012    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3202   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0347   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0347   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7492   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7492   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0347   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0347   -3.7741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7492   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3202   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3202   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6058   -1.2991    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8913   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  4  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 21 30  4  0  0  0  0
 25 30  4  0  0  0  0
 18 31  4  0  0  0  0
 14 31  4  0  0  0  0
 12 32  4  0  0  0  0
 32 33  2  0  0  0  0
 32 34  4  0  0  0  0
 10 34  4  0  0  0  0
 34 35  1  0  0  0  0
  6 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 39 42  4  0  0  0  0
 42 43  4  0  0  0  0
 36 43  4  0  0  0  0
 43 44  1  0  0  0  0
 44 45  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1248

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N=c2sc(=CC3=CC=CC(OCC4=CC=CC5=CC=CC=C45)=C3)c(=O)n2C1C6=CC=C(OC)C=C6OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>9.27

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-125
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
   -0.0987   -2.0064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2044   -1.2391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9717   -1.5421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5630   -0.9361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5074   -0.4718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0525    0.1342    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0722    0.9497    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6085    1.4159    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3525    1.0595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4159    0.2369    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0332    1.5256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7773    1.1692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8406    0.3467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5847   -0.0097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2654    0.4565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0673    0.2625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4995    0.9653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9647    1.5935    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2020    1.2790    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4579    1.6354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7875    1.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7276    2.1835    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5548    1.0577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2305    1.5312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8895    1.0349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6993    1.1927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2408    0.5702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9725   -0.2099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1627   -0.3677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6212    0.2548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7964    0.2688    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3302   -0.4118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
  7 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 23 31  4  0  0  0  0
 31 32  1  0  0  0  0
  5 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-125

>  <JC_XSMILES>
CC(C)(C)C1=NN(CC(=O)NC2=CC=C3OCOC3=C2)C(=O)C4=CC5=CC=CC=C5N4C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.16

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.81

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1254
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.9995    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.9132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7679   -3.1596    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -4.5807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7378   -4.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2227   -5.1619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8871   -5.9156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -6.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -5.3344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -3.3320    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -2.2925    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4827   -1.5079    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9925   -3.0771    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5222   -2.0375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -2.5896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9199   -2.3346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -1.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8761   -1.2727    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.4784   -0.9756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -1.2306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  4 14  4  0  0  0  0
 14 15  4  0  0  0  0
  2 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1254

>  <JC_XSMILES>
NC1=CC(OC(=O)C2=CC=CC=C2)=NN1S(=O)(=O)C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.923

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1255
  Mrv1591402191617072D          

 22 22  0  0  0  0            999 V2000
   -0.7145    5.3625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.3625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1255

>  <JC_XSMILES>
FC(F)C(F)(F)COS(=O)(=O)C1=CC=C(NC(=O)CCl)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.727

>  <W2 Pf proliferation inhibition EC50 uM>
1.58

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.12

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-126
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    1.9059    5.3903    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1608    4.6056    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6088    3.9926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498    3.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5572    3.7225    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8121    4.5071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8018    4.1641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5469    4.9487    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2601    5.1202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6904   -1.6839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6904   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6904    1.1740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 16 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 24 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-126

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1OC)C(=O)NC2=C3CSCC3=NN2C4=CC(C)=CC(C)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.907

>  <W2 Pf proliferation inhibition EC50 uM>
0.341

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>1.067

>  <Powder data?>
No

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1261
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  4  0  0  0  0
 14 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1261

>  <JC_XSMILES>
CCN1CCN(CC1)CC(O)COC2=CC=C(OC)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
2.806

>  <W2 Pf proliferation inhibition EC50 uM>
>9.19

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1264
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 18 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 27 36  4  0  0  0  0
  7 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1264

>  <JC_XSMILES>
C=CCNC(=O)C1=CC(OCC2=CC=CC=C2)=C(OCC3=CC=CC=C3)C(OCC4=CC=CC=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
10.75

>  <W2 Pf proliferation inhibition EC50 uM>
9.18

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1265
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -1.5078   -3.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7933   -2.8846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7933   -2.0596    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0788   -1.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0788   -0.8221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6357   -0.4096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3501   -0.8221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3501   -1.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6357   -2.0596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0646   -0.4096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791   -0.8221    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935   -0.4096    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -0.8221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -1.6471    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -0.4096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -0.8221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3514   -0.4096    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4377    0.4109    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2446    0.5824    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6571   -0.1320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4641   -0.3036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7190   -1.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1670   -1.7013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3600   -1.5298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1051   -0.7451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
 10  7  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 17 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1265

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)C=NNC(=O)CCN2N=NC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.042

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>13.63

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1269
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.5855    4.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480    3.9849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -3.1599    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 12 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1269

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)C2=NC3(CCN(CC3)C(C)C)NC(C2)C4=CC(Cl)=CC=C4O

>  <PF proliferation inhibition 3D7 EC50 uM>
7.18

>  <W2 Pf proliferation inhibition EC50 uM>
5.48

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
59.87

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-127
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
   -5.8207   -2.3098    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -5.1532   -1.8249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1532   -0.9999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3686   -0.7450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3686   -2.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5349   -2.4249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0869   -3.0380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6744   -3.7525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0100   -4.5061    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.8675   -3.5809    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 25 30  4  0  0  0  0
 21 31  4  0  0  0  0
 31 32  4  0  0  0  0
 18 32  4  0  0  0  0
 32 33  4  0  0  0  0
 16 33  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  33
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-127

>  <JC_XSMILES>
BrC1=CC=C(O1)C(=O)NC2=CC=C(C=C2)C3=NC4=CC=C(NC(=O)C5=CC=C(Br)O5)C=C4N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2939

>  <W2 Pf proliferation inhibition EC50 uM>
0.709

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.247

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1271
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -0.9303   -1.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2159   -1.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2159   -0.6721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4986   -1.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2131   -1.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9275   -1.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9275   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6420   -3.1471    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3565   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0709   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7854   -2.7346    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.4999   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2536   -2.8116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8056   -3.4247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6306   -3.4247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0431   -2.7102    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.0431   -4.1392    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6306   -4.8536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8056   -4.8536    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3931   -4.1392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5861   -3.9676    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2131   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4986   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
  7 22  4  0  0  0  0
 22 23  4  0  0  0  0
  4 23  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1271

>  <JC_XSMILES>
CC(=O)C1=CC=C(OCCSC2=NC3=C(N)N=CN=C3N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.18

>  <W2 Pf proliferation inhibition EC50 uM>
>9.15

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1272
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    3.5854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    4.4104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -0.5422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083   -1.4984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604   -0.8853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -0.1006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
  2 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  5 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1272

>  <JC_XSMILES>
CC1=NC2=C(C(C)=NN2C(C)=C1CC(=O)NCC3=CC=CC=N3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
9.14

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1286
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  3  0  0  0  0
  6  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
  2 11  4  0  0  0  0
 12 11  1  4  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1286

>  <JC_XSMILES>
CC1=CC(C)=C(C#N)C(=O)N1N=CC2=CC=CC(Cl)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
9.06

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-129
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -3.8062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2991   -2.7666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6860   -3.3186    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1276   -1.9596    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3430   -1.7047    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1714   -0.8977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6132   -0.6428    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7847    0.1642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1716    0.7162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6130    0.4613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7845   -0.3457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -0.6006    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.3431    1.5232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5147    2.3302    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.4638    1.6947    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1501    1.3517    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-129

>  <JC_XSMILES>
CN1C=CN=C1C(=O)NNC2=NC=C(C=C2Cl)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.609

>  <W2 Pf proliferation inhibition EC50 uM>
0.359

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.146

>  <Powder data?>
Yes

>  <IFI value>
0.1328125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1298
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  2  0  0  0  0
 17 19  4  0  0  0  0
  9 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
  6 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 35 36  4  0  0  0  0
 30 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1298

>  <JC_XSMILES>
CCCCCN(C(C)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3CC)C(=O)C4=CC=C(C)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.615

>  <W2 Pf proliferation inhibition EC50 uM>
0.895

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-130
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
  6 12  4  0  0  0  0
  4 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 17 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
 14 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-130

>  <JC_XSMILES>
CC1=CC(NC2=CC=CC(Cl)=C2)=NC3=CC=C(NC(=O)C4=CC=CN=C4)C=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.721

>  <W2 Pf proliferation inhibition EC50 uM>
1.307

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.19

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1301
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1369   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6218   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1369   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 20 21  4  0  0  0  0
  9 21  4  0  0  0  0
 13 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
  5 29  4  0  0  0  0
 29 30  4  0  0  0  0
  2 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1301

>  <JC_XSMILES>
CC1=CC=C(NC(=O)C2=C(N)C3=C(C4=C(CCC4)N=C3S2)C5=CC=C(C)C=C5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.787

>  <W2 Pf proliferation inhibition EC50 uM>
8.94

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.074074074

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1302
  Mrv1591402191617072D          

 48 56  0  0  0  0            999 V2000
    1.9339    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2181   -1.6207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9325   -2.0332    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5456   -1.4811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2101   -0.7275    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3526   -1.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6075   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4145   -2.6088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9665   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7116   -1.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9046   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5356   -1.9562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2030   -1.4713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9567   -1.8069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0430   -2.6273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3755   -3.1123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6218   -2.7767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0780   -0.7275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4135   -1.4811    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8004   -2.0332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0860   -1.6207    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8867   -2.8536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6403   -3.1892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7266   -4.0097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0591   -4.4946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3055   -4.1590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2192   -3.3386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4905   -0.0130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0780    0.7015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4905    1.4160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3155    1.4160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7280    0.7015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3155   -0.0130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  1  0  0  0  0
  9 14  4  0  0  0  0
 11 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 16 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
  6 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 32 36  4  0  0  0  0
 35 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
 33 43  1  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 43 48  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  36
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1302

>  <JC_XSMILES>
O=C1C2=CC=C(C=C2C3=CC(=CC=C13)C4=C(NC(=N4)C5=CC=CC=C5)C6=CC=CC=C6)C7=C(N=C(N7)C8=CC=CC=C8)C9=CC=CC=C9

>  <PF proliferation inhibition 3D7 EC50 uM>
9.19

>  <W2 Pf proliferation inhibition EC50 uM>
8.93

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1305
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -0.5837    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.1599    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 13 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1305

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C(=O)C2=C(NC(=O)CCl)C3=CC=CC=C3O2

>  <PF proliferation inhibition 3D7 EC50 uM>
10.18

>  <W2 Pf proliferation inhibition EC50 uM>
1.384

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.53

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1308
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  3 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1308

>  <JC_XSMILES>
CCC(NC1CCCCC1)C2=NC3=CC=CC=C3C(=O)N2C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.107

>  <W2 Pf proliferation inhibition EC50 uM>
0.888

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.025

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1309
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -1.4289    9.6536    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.7145    9.2411    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.0000    9.6536    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.9411    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674    4.2187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    4.2187    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.7036    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8971    5.6055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4491    6.2186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0366    6.9331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2296    6.7616    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 10 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1309

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)N(CC2=CC=CS2)C(=O)C3=CC=CS3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.677

>  <W2 Pf proliferation inhibition EC50 uM>
0.888

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019607843

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-131
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    2.2162   -4.1111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6114   -4.6722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8231   -4.4290    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2619   -5.0338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5634   -5.8018    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5607   -4.9721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9187   -5.7154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7414   -5.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2061   -5.0954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8482   -4.3521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0255   -4.2905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7823   -3.5021    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0143   -3.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0143   -2.3757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7001   -1.9632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4146   -2.3757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1291   -1.9632    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8435   -2.3757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8435   -3.2007    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5580   -1.9632    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2725   -2.3757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9870   -1.9632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7014   -2.3757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4159   -1.9632    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1304   -2.3757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8448   -1.9632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1304   -3.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4146   -3.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7001   -3.6132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 16 28  4  0  0  0  0
 28 29  4  0  0  0  0
  3 29  1  0  0  0  0
 13 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-131

>  <JC_XSMILES>
CCN1C(=O)C2=CC=CC=C2SC3=CC=C(NC(=O)NCCCOC(C)C)C=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
>10

>  <W2 Pf proliferation inhibition EC50 uM>
>10

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
32.09

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1311
  Mrv1591402191617072D          

 42 46  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.1434    4.5375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  3 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
  2 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  2  0  0  0  0
 32 34  4  0  0  0  0
 24 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  1  0  0  0  0
 39 41  4  0  0  0  0
 35 41  4  0  0  0  0
 41 42  1  0  0  0  0
M  CHG  2  21   1  22  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1311

>  <JC_XSMILES>
CC(N(CCC1=CC=CC=C1)C(=O)C2=CC=C(C)C(=C2)[N+]([O-])=O)C3=NC4=CC=CC=C4C(=O)N3C5=CC=CC(Cl)=C5C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.615

>  <W2 Pf proliferation inhibition EC50 uM>
0.887

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019230769

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1313
  Mrv1591402191617072D          

 43 47  0  0  0  0            999 V2000
   -0.3216   -7.9741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8065   -7.3067    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4709   -6.5530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9559   -5.8856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6203   -5.1319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2002   -5.0457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6851   -5.7131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3495   -6.4668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5357   -4.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1232   -3.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6753   -2.9644    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3427   -4.1205    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 21 30  4  0  0  0  0
 18 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 33 42  4  0  0  0  0
 37 42  4  0  0  0  0
 12 43  4  0  0  0  0
  9 43  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1313

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=NN=C(NC(=O)CCN(CCC3=CC=C(OC)C(OC)=C3)C(=O)C4=CC=CC5=CC=CC=C45)S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.934

>  <W2 Pf proliferation inhibition EC50 uM>
>1.202

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>13.57

>  <Powder data?>
No

>  <IFI value>
0.038095238

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1315
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    2.8315    1.8609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4634    1.3304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9249    2.0143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1917    0.9429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9670    1.2249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5989    0.6945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4554   -0.1179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6801   -0.3999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0483    0.1305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2313    0.0159    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8438   -0.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2808   -1.4122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8933   -2.1405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0688   -2.1691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6318   -1.4694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0193   -0.7411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8698    0.7575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3393    0.1256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5269    0.2691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9965   -0.3628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2784   -1.1381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7480   -1.7700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0644   -1.6265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1840   -0.2194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0980    0.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4325    1.1878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2449    1.0444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7754    1.6762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5878    1.5328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9104    0.6994    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.4408    0.0675    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.1924    1.4747    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 10 17  1  0  0  0  0
  2 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 20 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 19 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 17 29  1  0  0  0  0
 25 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  2  0  0  0  0
M  CHG  2  30   1  31  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1315

>  <JC_XSMILES>
CC1(C)C2=CC=CC=C2N(C3=CC=CC=C3)C14OC5=C(CC=C)C=C(C=C5C=C4)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.396

>  <W2 Pf proliferation inhibition EC50 uM>
0.885

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1317
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    2.0367   -0.4741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4748   -3.9898    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9899   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3255   -5.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8406   -6.0783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0201   -5.9921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3155   -5.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1694   -4.5710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  7  5  1  4  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  1 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1317

>  <JC_XSMILES>
N(C1=NN=C(S1)N=NC2=CC=CC=C2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.957

>  <W2 Pf proliferation inhibition EC50 uM>
0.884

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1319
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -0.7240   -1.2292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0932   -1.1161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4038   -0.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1027    0.2994    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2079    1.0637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0251    1.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4879    1.8598    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2804    1.6307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9316    2.1373    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3075    0.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0834    1.0867    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5899    0.4355    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1271   -0.2475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3346   -0.0184    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4077   -1.0233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2199   -1.1683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5004   -1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9688   -2.5750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2493   -3.3508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1566   -2.4300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8761   -1.6542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5317    0.5256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2210   -0.2387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 10 22  1  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
  3 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1319

>  <JC_XSMILES>
CCC1=CC=C2NC(=O)C3(NN=C(S3)C4=CC=C(C)C=C4)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.491

>  <W2 Pf proliferation inhibition EC50 uM>
2.101

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.81

>  <Powder data?>
Yes

>  <IFI value>
0.093023256

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-132
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 13 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 12 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 33 34  4  0  0  0  0
 28 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-132

>  <JC_XSMILES>
COC1=CC=CC=C1\C=C/CN(C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)C4=CC=C(C)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.117

>  <W2 Pf proliferation inhibition EC50 uM>
>1.352

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>4.36

>  <Powder data?>
No

>  <IFI value>
0.021978022

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1320
  Mrv1591402191617072D          

 17 17  0  0  0  0            999 V2000
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5395   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  2  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 11 17  4  0  0  0  0
  6 17  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1320

>  <JC_XSMILES>
CCN(CC)C1=NC(S)=NC(NC(C)(C)C)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>8.81

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1327
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    1.5356    4.8884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8212    4.4759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067    4.8884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    4.8884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    5.7134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    6.1259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067    5.7134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8212    6.1259    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    4.8884    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    4.4759    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    3.2384    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5127    1.9285    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7676    1.1438    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5926    1.1438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0775    0.4764    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8476    1.9285    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
 10  5  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1327

>  <JC_XSMILES>
COC1=CC(=CC=C1O)C=NNC(=O)CC2=NN=C(N)S2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.115

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>12.69

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-133
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8860    2.0445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3340    2.6576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4730    2.4860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7279    1.7014    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0250    3.0991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8535    3.9061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5680    4.3186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1811    3.7666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9880    3.9381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8455    3.0129    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065    2.1307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0420    1.3770    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190    2.8452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9440    2.8452    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065    3.5596    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190    4.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 16 21  4  0  0  0  0
 12 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 11 24  4  0  0  0  0
 24 25  4  0  0  0  0
  8 25  4  0  0  0  0
 22 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-133

>  <JC_XSMILES>
CCCCN(C)CC1=CC=C2C(NC(=O)C3=CC=C(C)S3)=C(SC2=N1)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.542

>  <W2 Pf proliferation inhibition EC50 uM>
0.461

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.516

>  <Powder data?>
No

>  <IFI value>
0.017241379

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1335
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
 18 29  4  0  0  0  0
 29 30  4  0  0  0  0
 15 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1335

>  <JC_XSMILES>
COC1=CC=CC=C1N2CCN(CC2)C3=CC=C(NC(=O)C4=CC=C(Br)C=C4)C=C3C(=O)NCCCN(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.1171

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.338

>  <Powder data?>
No

>  <IFI value>
0.030927835

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-134
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  4  0  0  0  0
  8 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-134

>  <JC_XSMILES>
CN1CCN(CC1)C2=CC=C(NC(=O)OC3=CC=CC=C3)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
4.17

>  <W2 Pf proliferation inhibition EC50 uM>
7.48

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
25.39

>  <Powder data?>
Yes

>  <IFI value>
0.012048193

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1342
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    5.0501   -3.1318    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7646   -3.5443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7646   -4.3693    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4790   -3.1318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1935   -3.5443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9080   -3.1318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6224   -3.5443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3369   -3.1318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0514   -3.5443    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7659   -3.1318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7659   -2.3068    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4803   -1.8943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1948   -2.3068    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1948   -3.1318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4803   -3.5443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6519   -4.3513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4723   -4.4375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8079   -5.1912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3230   -5.8586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5025   -5.7724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1669   -5.0187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8079   -3.6838    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  4  0  0  0  0
 14 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1342

>  <JC_XSMILES>
OC(=O)CCCCCNC1=NC=NC2=C1C3=C(CCCC3)S2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.869

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.007407407

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1343
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 15 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1343

>  <JC_XSMILES>
COC1=CC=CC=C1CCNCC2=CC(=CC=C2O)C3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.048

>  <W2 Pf proliferation inhibition EC50 uM>
0.869

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009090909

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1344
  Mrv1591402191617072D          

 28 29  0  0  0  0            999 V2000
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 22 23  4  0  0  0  0
 14 23  4  0  0  0  0
 23 24  1  0  0  0  0
  7 25  4  0  0  0  0
 25 26  4  0  0  0  0
  3 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1344

>  <JC_XSMILES>
COC1=CC(Br)=C(CCNC(=O)CC2=CC(OC)=C(OC)C=C2Br)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>8.77

>  <W2 Pf proliferation inhibition EC50 uM>
>8.68

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.030075188

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-135
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  4 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  3 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  2  0  0  0  0
 29 31  4  0  0  0  0
 21 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  1  0  0  0  0
 36 38  4  0  0  0  0
 32 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-135

>  <JC_XSMILES>
CCC(N(CCC(C)C)C(=O)COCC1=CC=CC=C1)C2=NC3=CC=CC=C3C(=O)N2C4=CC=CC(Cl)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.194

>  <W2 Pf proliferation inhibition EC50 uM>
>1.143

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.91

>  <Powder data?>
No

>  <IFI value>
0.009090909

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1353
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9849   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
  2 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  2  0  0  0  0
 24 26  4  0  0  0  0
 15 26  4  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1353

>  <JC_XSMILES>
CC(N1CCN(CC1)C(=O)C(C)(C)C)C2=NC3=CC=C(Cl)C=C3C(=O)N2C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.467

>  <W2 Pf proliferation inhibition EC50 uM>
0.86

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1357
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    2.8579    2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 13 12  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 11 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 23 31  4  0  0  0  0
  9 31  4  0  0  0  0
  7 32  4  0  0  0  0
 32 33  4  0  0  0  0
  4 33  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1357

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(NC2=NC(NN=CC3=CC=CC=C3I)=NC(NC4=CC=CC=C4)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.846

>  <W2 Pf proliferation inhibition EC50 uM>
2.822

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
32.82

>  <Powder data?>
Yes

>  <IFI value>
0.026315789

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1359
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8445   -1.7701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4576   -2.3221    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1721   -1.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9258   -2.2452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0006   -1.1027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1359

>  <JC_XSMILES>
CCNC1=NC=NC2=C1C(C)=C(S2)C(=O)NCC3=CSC(C)=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>8.59

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1367
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
    7.3589   -5.5944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5519   -5.4229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9999   -6.0360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2970   -4.6383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4900   -4.4668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2351   -3.6821    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4281   -3.5106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8761   -4.1237    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1732   -2.7260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3662   -2.5545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1113   -1.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4703   -1.3283    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5322   -2.2844    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0842   -1.6713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8912   -1.8429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1461   -2.6275    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9531   -2.7990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5051   -2.1859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3121   -2.3574    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5941   -3.2406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7871   -3.0690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
 15 23  1  0  0  0  0
 12 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 28 36  4  0  0  0  0
 31 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1367

>  <JC_XSMILES>
CN(C)CCNC(=O)C1=CC=C(N=C1N2CCN(CCO)CC2)C3=CC=CC4=C3SC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.388

>  <W2 Pf proliferation inhibition EC50 uM>
0.452

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.32

>  <Powder data?>
No

>  <IFI value>
0.113043478

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1371
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -0.5837    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.1599    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8913    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3038    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8913    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    0.7310    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2822   -1.8800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1371

>  <JC_XSMILES>
COC1=CC=CC=C1NC(=O)CSC2=NC3=CC=CN=C3N2C4=CC=CC=C4OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.833

>  <W2 Pf proliferation inhibition EC50 uM>
0.848

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1377
  Mrv1591402191617072D          

 26 29  0  0  1  0            999 V2000
   -4.1807    0.9699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1807   -0.1449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.6039    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6075   -1.6305    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.6421   -1.0731    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  6  5  1  0  0  0  0
  6  7  1  1  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 20  6  1  0  0  0  0
 20 21  1  6  0  0  0
 20 22  1  0  0  0  0
 22 23  1  1  0  0  0
  2 23  1  0  0  0  0
  4 23  1  0  0  0  0
 22 24  1  0  0  0  0
 20 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1377

>  <JC_XSMILES>
CC1(C)C2C[C@@H](COC(=O)NC(=O)C3=CC=CC=C3)[C@]4(C)[C@H](C12)C4(Cl)Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
1.137

>  <W2 Pf proliferation inhibition EC50 uM>
0.951

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.25

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1378
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 15 24  4  0  0  0  0
  6 24  4  0  0  0  0
 24 25  4  0  0  0  0
  3 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1378

>  <JC_XSMILES>
COC1=CC=C2N=C3C=C(Cl)C=CC3=C(NC4=CC=C(O)C=C4)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.809

>  <W2 Pf proliferation inhibition EC50 uM>
0.845

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1379
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4710   -3.5195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5316   -3.5195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
  5 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
  4 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1379

>  <JC_XSMILES>
CC1CC2=C(CC1CNCCCN(C)C)C(C)(C)CCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2497

>  <W2 Pf proliferation inhibition EC50 uM>
0.844

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1383
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  5 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
M  CHG  2  15   1  16  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1383

>  <JC_XSMILES>
CC1=CN=C(SC2=CC=CC=N2)C(=C1)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
6.13

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
72.86

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1384
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.1599    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  2 10  4  0  0  0  0
  5 10  4  0  0  0  0
  7 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  3 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1384

>  <JC_XSMILES>
NC1=C(SC2=NC(=CC=C12)C3=CC=CN=C3)C(=O)C4=CC=C(Br)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.297

>  <W2 Pf proliferation inhibition EC50 uM>
>1.091

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>12.97

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1385
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 25 31  4  0  0  0  0
  5 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 37 38  4  0  0  0  0
  3 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1385

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=CC=C2OC)C(=O)NC3=CC=CC(F)=C3)=C4N=CC=CC4=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.664

>  <W2 Pf proliferation inhibition EC50 uM>
0.84

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.048076923

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1389
  Mrv1591402191617072D          

 35 42  0  0  1  0            999 V2000
    1.8744   -1.5099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6171   -1.1510    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6777   -0.3283    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.4341    0.0841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5335    1.0054    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.7825    1.0941    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0388    1.0800    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.2155    1.0287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9973    0.1846    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.2506   -0.1662    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1811   -0.9882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8842    1.9772    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0834    2.2887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3424    1.9264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3420    2.3870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2853    3.2100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4558    3.5723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1402    3.1118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9680    3.3503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4180    4.0581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1607    4.8419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8266    5.3289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4955    4.8460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2793    5.1033    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2430    4.0607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7051    3.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5323    3.0979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2079    3.5711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9557    3.2227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0276    2.4008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3520    1.9276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6043    2.2761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7852    1.9082    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2635    2.6116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4187    2.6515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  1  0  0  0
  3  4  1  0  0  0  0
  5  4  1  0  0  0  0
  5  6  1  1  0  0  0
  7  6  1  0  0  0  0
  7  8  1  6  0  0  0
  9  7  1  0  0  0  0
  9  3  1  0  0  0  0
  9 10  1  1  0  0  0
 10 11  1  0  0  0  0
  7 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  4  0  0  0  0
  5 33  1  0  0  0  0
 33 34  4  0  0  0  0
 26 34  4  0  0  0  0
 34 35  4  0  0  0  0
 12 35  4  0  0  0  0
 19 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1389

>  <JC_XSMILES>
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)N3C4=CC=CC=C4C5=C6CNC(=O)C6=C7C8=CC=CC=C8N2C7=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0547

>  <W2 Pf proliferation inhibition EC50 uM>
0.02975

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.355

>  <Powder data?>
Yes

>  <IFI value>
0.4125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1394
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -9.4875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.1763   -8.6625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.8263   -8.6625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
  9 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
  6 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1394

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N(CCNC2=NC=C(C=C2Cl)C(F)(F)F)C(=O)CC1

>  <PF proliferation inhibition 3D7 EC50 uM>
7.67

>  <W2 Pf proliferation inhibition EC50 uM>
8.35

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1396
  Mrv1591402191617072D          

 37 36  0  0  0  0            999 V2000
   10.6954   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2829   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4579   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0454   -2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2204   -2.1434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8079   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2204   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8079    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2204    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8079   -2.8579    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
    7.3954   -3.5724    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -3.5724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -4.2868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -4.2868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -5.0013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8079   -4.2868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -5.0013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8079   -5.7158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -6.4302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0934   -2.4454    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3789   -2.8579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6645   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9500   -2.8579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2355   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0934   -1.6204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3789   -1.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6645   -1.6204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9500   -1.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5224   -3.2704    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2368   -2.8579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9513   -3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6658   -2.8579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3802   -3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5224   -4.0954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2368   -4.5079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9513   -4.0954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6658   -4.5079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 10 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 20 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 10 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 29 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
M  CHG  1  10   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1396

>  <JC_XSMILES>
CCCCN(CCCC)[P+](N(CCCC)CCCC)(N(CCCC)CCCC)N(CCCC)CCCC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2242

>  <W2 Pf proliferation inhibition EC50 uM>
0.0654

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.784

>  <Powder data?>
Yes

>  <IFI value>
0.272727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1397
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 23 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  1  0  0  0  0
 37 39  4  0  0  0  0
 39 40  4  0  0  0  0
 34 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1397

>  <JC_XSMILES>
CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N(CCC4=CC=CC=C4)C(=O)C5=CC=C(Br)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.834

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.057142857

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1401
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    1.4743   -2.1191    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4243   -1.7779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4243   -2.6029    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2902   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  2 10  1  0  0  0  0
  5 10  4  0  0  0  0
  7 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
  2 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1401

>  <JC_XSMILES>
NC1(CCC2=CC(=CC=C12)C(O)=O)C(O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.155

>  <W2 Pf proliferation inhibition EC50 uM>
0.833

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.014814815

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1402
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    1.4289   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    9.2411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    5.9411    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964    4.2187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315    2.7666    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615    4.2187    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 11 16  4  0  0  0  0
  7 17  4  0  0  0  0
 17 18  4  0  0  0  0
  4 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1402

>  <JC_XSMILES>
CCOC1=CC=C(NC(=O)C2=CC=C(I)O2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.85

>  <W2 Pf proliferation inhibition EC50 uM>
5.79

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
69.56

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1403
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 12 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1403

>  <JC_XSMILES>
CC1CCN(CC1)C(=O)C(C)N(C2=CC=CC=C2)S(C)(=O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
7.2

>  <W2 Pf proliferation inhibition EC50 uM>
8.32

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1405
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 10 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1405

>  <JC_XSMILES>
CCCCCCOC(=O)C1=C(C)NC(=O)NC1C2=CC=CC=C2F

>  <PF proliferation inhibition 3D7 EC50 uM>
>6.76

>  <W2 Pf proliferation inhibition EC50 uM>
>8.31

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.007142857

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1406
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
  3 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 20 28  4  0  0  0  0
 28 29  2  0  0  0  0
 28 30  4  0  0  0  0
 17 30  4  0  0  0  0
 30 31  4  0  0  0  0
 14 31  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1406

>  <JC_XSMILES>
CCN(C1=CC=C(F)C=C1)S(=O)(=O)C2=CC=C3NC=C(C(=O)NC(C)(C)C)C(=O)C3=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.603

>  <W2 Pf proliferation inhibition EC50 uM>
0.83

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-141
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -2.1434   10.0661    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414    8.9391    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164   10.3680    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.1786    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    7.1786    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.9812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.9812    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
  9 24  4  0  0  0  0
  5 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-141

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(NC(=O)C2=CC=C(C=C2)C3=CC=CS3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
10.01

>  <W2 Pf proliferation inhibition EC50 uM>
1.935

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.13

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1411
  Mrv1591402191617072D          

 28 27  0  0  0  0            999 V2000
    3.0670    1.3773    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8770    1.2214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1471    0.4420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9571    0.2861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2272   -0.4935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0372   -0.6493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3072   -1.4288    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
    6.5773   -2.2083    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3873   -2.3642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6574   -3.1438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4674   -3.2996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0372   -2.8319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3072   -3.6114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7673   -4.2350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5278   -1.6989    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9042   -1.1588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1247   -1.4288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5011   -0.8888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3719   -2.5089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5923   -2.7790    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9688   -2.2389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0868   -1.1588    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7103   -1.6989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4898   -1.4288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1134   -1.9688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2426   -0.3488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0222   -0.0787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6457   -0.6188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  8 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  7 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
  7 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 22 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  CHG  1   7   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1411

>  <JC_XSMILES>
CCCCCC[P+](N(CCC)CCC)(N(CCC)CCC)N(CCC)CCC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0704

>  <W2 Pf proliferation inhibition EC50 uM>
0.0956

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.156

>  <Powder data?>
Yes

>  <IFI value>
0.290909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1412
  Mrv1591402191617072D          

 20 23  0  0  0  0            999 V2000
    3.8905    0.1425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3384    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5934    1.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5314    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2765   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4695   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9175    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0925    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5214    0.5840    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.3284    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0023    2.1816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3349    2.6666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4188    2.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    1.5105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1724    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9794    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
  7 18  4  0  0  0  0
 18 19  4  0  0  0  0
  4 19  4  0  0  0  0
 17 20  4  0  0  0  0
  8 20  4  0  0  0  0
 13 20  4  0  0  0  0
M  CHG  1  11   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1412

>  <JC_XSMILES>
CC(C)C1=CC=C2N3C=C[N+](C)=C4CCCC(C2=C1)=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
1.724

>  <W2 Pf proliferation inhibition EC50 uM>
2.63

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
31.81

>  <Powder data?>
Yes

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1419
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -4.9820    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2460   -5.6495    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -4.1974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5955   -3.9425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2086   -4.4945    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7670   -3.1355    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5516   -2.8806    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7231   -2.0736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5078   -1.8187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6793   -1.0117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4639   -0.7568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0770   -1.3088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9055   -2.1158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5186   -2.6678    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    6.1209   -2.3707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  2  7  4  0  0  0  0
  3  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 11 10  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 13 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1419

>  <JC_XSMILES>
CC1=C(SC(N)=N1)C(=O)NN=CC2=CC=CC(Br)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.819

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-142
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
 10  9  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 17 23  4  0  0  0  0
  9 24  4  0  0  0  0
  4 24  4  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-142

>  <JC_XSMILES>
CCOC1=CC(Br)=CC(C=NNC(=O)COC2=CC=CC(C)=C2)=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
7.52

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>46.25

>  <Powder data?>
Yes

>  <IFI value>
0.051470588

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1427
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    4.7086   -5.5844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9635   -4.7998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4115   -4.1867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6664   -3.4021    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1815   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3565   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9440   -2.0202    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190   -2.0202    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065   -1.3057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8860   -1.2195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0420   -0.5520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6664   -2.0672    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4510   -2.3221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1655   -1.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8800   -2.3221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8800   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1655   -3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4510   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  6  5  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
  5 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1427

>  <JC_XSMILES>
CCCN1C(C=NNC2=NC3=CC=CC=C3N2)=NC4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
5.56

>  <W2 Pf proliferation inhibition EC50 uM>
5.11

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
62.84

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1428
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.3197   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9697   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 11  8  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1428

>  <JC_XSMILES>
CCCOC1=CC=C(C=C1)C=NC2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.41

>  <W2 Pf proliferation inhibition EC50 uM>
0.813

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1430
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 12 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 10 30  4  0  0  0  0
  7 31  4  0  0  0  0
 31 32  4  0  0  0  0
  4 32  4  0  0  0  0
M  CHG  1  24   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1430

>  <JC_XSMILES>
CN(C)C1=CC=C(\C=C\C2=CC(\C=C\C3=CC=C(C=C3)N(C)C)=[N+]4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.336

>  <W2 Pf proliferation inhibition EC50 uM>
0.811

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.214285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1432
  Mrv1591402191617072D          

 36 40  0  0  1  0            999 V2000
    2.0367   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -1.7116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.4656    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    2.4134    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.1759    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.6091    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9910   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7360   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9110   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6561   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    4.8884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    3.6509    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 15 12  1  6  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 20 19  1  0  0  0  0
 15 20  1  0  0  0  0
 20 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 25 29  1  0  0  0  0
 18 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1432

>  <JC_XSMILES>
COC1=CC=CC=C1N2CCN(CC2)[C@@H]3CCN(C[C@@H]3CCC(=O)N4CCCC4)CC5=CC=CN=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.085

>  <W2 Pf proliferation inhibition EC50 uM>
0.81

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.026785714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1433
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    4.4380   -3.6505    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.8505   -2.9360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5650   -3.3485    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.1360   -2.5235    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.2630   -2.2216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8505   -1.5071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2630   -0.7926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8505   -0.0781    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0255   -0.0781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6130   -0.7926    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6130    0.6363    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7880    0.6363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4300    1.3796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6257    1.5632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9807    1.0488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9807    0.2238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6257   -0.2905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4300   -0.1070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3940    0.6363    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5690    0.6363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0841   -0.0311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7005    0.2238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7005    1.0488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0841    1.3038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0880   -0.7926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5005   -1.5071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0880   -2.2216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5005   -2.9360    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 12 18  1  0  0  0  0
 17 19  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 20 24  1  0  0  0  0
  7 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1433

>  <JC_XSMILES>
FC(F)(F)C1=CC(NC(=O)NC2CC3CCC(C2)N3C4CCCC4)=CC=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.541

>  <W2 Pf proliferation inhibition EC50 uM>
0.81

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.012820513

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1434
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
   -0.0320   -4.5888    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.8570   -4.5888    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.2695   -5.3033    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2695   -3.8743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0945   -3.8743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5070   -3.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0945   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2695   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8570   -3.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5070   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3320   -1.7309    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0945   -1.0164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3320   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3320    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0945    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2695    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0395   -1.0396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5082    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0395    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 23 27  1  0  0  0  0
 25 28  1  0  0  0  0
 22 28  1  0  0  0  0
 28 29  1  0  0  0  0
 19 29  1  0  0  0  0
 29 30  2  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1434

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)C(=O)OC2=CC=CC=C2N3C(=O)C4C5CC(C=C5)C4C3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.74

>  <W2 Pf proliferation inhibition EC50 uM>
8.07

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1435
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
  5 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 13 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 12 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1435

>  <JC_XSMILES>
CC(=O)N(C1=CC=C(F)C=C1)C2=C(N3CCOCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01294

>  <W2 Pf proliferation inhibition EC50 uM>
0.01398

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.1733

>  <Powder data?>
No

>  <IFI value>
0.246753247

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1437
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -2.0108    0.3392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2262    0.5942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6131    0.0422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1715    0.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 Sn  0  0  0  0  0  0  0  0  0  0  0  0
    0.1146   -0.7363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1965   -1.5572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9484   -1.8968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6184   -1.4154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0937    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9007    1.3686    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0937   -1.7070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9007   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1556   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6036   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8585   -4.0609    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7966   -3.1047    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5417   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7347   -2.1486    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
  5 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 25 26  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  24
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1437

>  <JC_XSMILES>
CCCC[Sn]1(CCCC)OC2C(CO)OC(C2O1)N3C=CC(=O)NC3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.916

>  <W2 Pf proliferation inhibition EC50 uM>
0.803

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1439
  Mrv1591402191617072D          

 30 34  0  0  1  0            999 V2000
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.1468    1.6002    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6165    0.6817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0862    1.3137    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3343   -0.0935    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.4776   -0.9060    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2977   -0.6238    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.1101   -0.7671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  1  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  4 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 14 12  1  0  0  0  0
 14 15  1  1  0  0  0
 16 15  1  1  0  0  0
 16  3  1  0  0  0  0
 16 14  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  6  0  0  0
 17 19  1  0  0  0  0
 19 20  1  6  0  0  0
 19 21  1  0  0  0  0
 21 22  1  6  0  0  0
 23 21  1  0  0  0  0
 14 23  1  0  0  0  0
 23 24  1  6  0  0  0
 19 25  1  1  0  0  0
 25 26  2  0  0  0  0
 27 25  1  6  0  0  0
 27 28  1  0  0  0  0
 29 28  1  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  1  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1439

>  <JC_XSMILES>
CO[C@H]1C2=C(OC)C=CC=C2C(=O)[C@@]34O[C@@]13[C@@H](O)[C@@](O)([C@@H](C)[C@H]4O)C(=O)[C@@H]5O[C@H]5C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2641

>  <W2 Pf proliferation inhibition EC50 uM>
0.2257

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.817

>  <Powder data?>
No

>  <IFI value>
0.203703704

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-144
  Mrv1591402191617072D          

 36 41  0  0  0  0            999 V2000
   -3.0091   -0.1648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2021    0.0067    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6501   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9050   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3530   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5460   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1215   -2.3175    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7889   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5340   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0860   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8930   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1479   -1.3910    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5959   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8508   -2.7887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6578   -2.9602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9127   -3.7449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3607   -4.3580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6156   -5.1426    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0636   -5.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5537   -4.1864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0017   -4.7995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1947   -4.6280    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3573   -5.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1858   -6.0481    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9003   -6.4606    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5134   -5.9085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1778   -5.1549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3203   -6.0801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5753   -6.8647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3822   -7.0362    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9343   -6.4231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6793   -5.6385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8724   -5.4670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2988   -3.4018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2910   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8431   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 23 27  4  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 20 34  4  0  0  0  0
 14 34  4  0  0  0  0
  9 35  4  0  0  0  0
  6 35  4  0  0  0  0
 35 36  4  0  0  0  0
  3 36  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   7
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-144

>  <JC_XSMILES>
COC1=CC=C2NC3=C(CCNC3C4=CC=C(OC)C(CSC5=NN=C(O5)C6=CC=CC=C6)=C4)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.05

>  <W2 Pf proliferation inhibition EC50 uM>
1.992

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.42

>  <Powder data?>
Yes

>  <IFI value>
0.023076923

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1444
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 13 23  4  0  0  0  0
 23 24  2  0  0  0  0
  6 25  4  0  0  0  0
 25 26  4  0  0  0  0
  3 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1444

>  <JC_XSMILES>
COC1=CC=C(CCNC(=O)CN2C(C)=CC3=CC=CC=C3C2=O)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.539

>  <W2 Pf proliferation inhibition EC50 uM>
0.796

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1446
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
   -4.2868   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 13 20  4  0  0  0  0
  9 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1446

>  <JC_XSMILES>
ClCC(=O)NCCCN(C(=O)NC1=CC=C(Cl)C(Cl)=C1)C2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2166

>  <W2 Pf proliferation inhibition EC50 uM>
0.074

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>0.931

>  <Powder data?>
No

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1447
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  1 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 13 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1447

>  <JC_XSMILES>
C1CC2=CC=CC=C2CN1C3=CC(=NC(=N3)C4=CC=NC=C4)C5=CC=CN=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.602

>  <W2 Pf proliferation inhibition EC50 uM>
0.794

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1449
  Mrv1591402191617072D          

 14 14  0  0  0  0            999 V2000
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
  5 14  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1449

>  <JC_XSMILES>
CCCCC1=CC=C(NC(C)=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2138

>  <W2 Pf proliferation inhibition EC50 uM>
0.334

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.21

>  <Powder data?>
Yes

>  <IFI value>
0.021276596

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1456
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 14 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1456

>  <JC_XSMILES>
COC1=CC=CC(OC)=C1C(=O)OC2=CC=CC3=CC=C(C)N=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.788

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.013888889

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1457
  Mrv1591402191617072D          

 16 16  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1457

>  <JC_XSMILES>
CC1=CC=CN=C1NC(=O)CCCC(O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.067

>  <W2 Pf proliferation inhibition EC50 uM>
0.788

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-146
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 22 28  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-146

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1OC)C2=NC3=CC=C(C=C3N2)N4CCN(C)CC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.733

>  <W2 Pf proliferation inhibition EC50 uM>
5.57

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.16

>  <Powder data?>
Yes

>  <IFI value>
0.060240964

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1460
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    0.6078    3.6509    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    4.0634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7347    3.3489    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.9097    4.7779    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    5.3009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    5.7134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    5.3009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.0634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    4.0634    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676    3.3489    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926    4.7779    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    3.6509    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    2.8259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    1.5884    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2765    1.1035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0216    0.3188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1966    0.3188    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9416    1.1035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570    1.3584    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    6.5384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    7.3634    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.5762    6.5384    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.9262    6.5384    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  2  0  0  0  0
  7 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1460

>  <JC_XSMILES>
FC(F)(F)C1=CC(=CC(=C1)S(=O)(=O)NCCN2CCNC2=O)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.199

>  <W2 Pf proliferation inhibition EC50 uM>
0.786

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1462
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9849   -2.1730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599   -3.6020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 17 23  1  0  0  0  0
 20 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 12 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 35 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1462

>  <JC_XSMILES>
CC(C)COC(=O)C1=C(C)N=C(N=C1C(=O)N2CCN(C(C)C2)S(=O)(=O)\C=C\C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.931

>  <W2 Pf proliferation inhibition EC50 uM>
0.785

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1463
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830    3.9995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    0.8205    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  7 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
  5 23  1  0  0  0  0
 23 24  2  0  0  0  0
  6 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1463

>  <JC_XSMILES>
CC(C)CN1C(C(C(=O)NC2=NC(C)=CS2)C3=CC=CC=C3C1=O)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.611

>  <W2 Pf proliferation inhibition EC50 uM>
0.785

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1469
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -4.6480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -6.0770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1469

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)S(=O)(=O)C3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.38

>  <W2 Pf proliferation inhibition EC50 uM>
0.3136

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.01

>  <Powder data?>
No

>  <IFI value>
0.096774194

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1471
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
  5 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 36 37  4  0  0  0  0
  3 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1471

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=C(F)C=C2)C(=O)CCC3=CC=CC=C3)=C4N=CC=CC4=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.399

>  <W2 Pf proliferation inhibition EC50 uM>
0.361

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.62

>  <Powder data?>
No

>  <IFI value>
0.017094017

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1472
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    5.6375   -1.1945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9230   -0.7820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9230    0.0430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2086   -1.1945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2086   -2.0195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4941   -2.4320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -1.1945    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0652   -2.4320    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0652   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7326   -3.7419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4777   -4.5266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6527   -4.5266    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3977   -3.7419    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6131   -3.4870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.0390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846   -3.7841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9561   -2.9771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3431   -2.4251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4416   -2.6800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9626   -5.1940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4475   -5.8614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2951   -5.6789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6300   -4.7091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9230   -2.4320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9230   -3.2570    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6375   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3520   -2.4320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4382   -3.2525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2452   -3.4240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6577   -2.7096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1057   -2.0965    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  5 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 28 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1472

>  <JC_XSMILES>
CC(C)CN(CC(=O)NC1=CC(=NN1C2=CC=CC=C2)C(C)(C)C)C(=O)CC3=CC=CS3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.298

>  <W2 Pf proliferation inhibition EC50 uM>
0.781

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1473
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  5 14  4  0  0  0  0
  9 14  4  0  0  0  0
  1 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 17 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  CHG  2   5   1  17   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1473

>  <JC_XSMILES>
C(CCC[N+]1=CC=CC2=CC=CC=C12)CC[N+]3=CC=CC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.406

>  <W2 Pf proliferation inhibition EC50 uM>
0.78

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1476
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    5.6479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1171    6.1329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3720    6.9175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1970    6.9175    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4520    6.1329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    1.5229    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
  9 19  4  0  0  0  0
  2 19  4  0  0  0  0
 19 20  1  0  0  0  0
  6 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1476

>  <JC_XSMILES>
CC1=NC2=CC(=NN2C(NCCCN3C=CN=C3)=C1C)C4=CC=C(F)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.99

>  <W2 Pf proliferation inhibition EC50 uM>
0.776

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1477
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  6 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
  3 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1477

>  <JC_XSMILES>
COC1=CC=C(NC2=CC(=O)CC(C2)C3=CC=CC=C3)C(OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.48

>  <W2 Pf proliferation inhibition EC50 uM>
7.74

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-148
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -4.7651   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2251   -2.0171    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4149   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8748   -1.5493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5246   -1.0816    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444   -2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261    0.3216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362    0.1657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763    0.7893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6864    0.6334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9565   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7666   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3067    0.3216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6864   -1.5493    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4966   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -1.7052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164   -2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763   -3.5762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7946   -2.4848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9845   -2.6407    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2546   -4.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647   -3.8880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3347   -3.1084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1449   -2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 14 23  4  0  0  0  0
 12 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 27 32  1  0  0  0  0
  5 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
 38 39  4  0  0  0  0
  3 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-148

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=C(OC)C(OC)=C2)C(=O)NC3CCCCC3)=C4N=CC=CC4=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.676

>  <W2 Pf proliferation inhibition EC50 uM>
0.337

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.303

>  <Powder data?>
No

>  <IFI value>
0.031914894

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1480
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
  6 12  4  0  0  0  0
 12 13  1  0  0  0  0
  3 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  CHG  1  14   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1480

>  <JC_XSMILES>
CN1C(COC2=CC=C(Cl)C=C2Cl)=[N+](C)C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2613

>  <W2 Pf proliferation inhibition EC50 uM>
0.773

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1482
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 18 28  4  0  0  0  0
 28 29  4  0  0  0  0
 15 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 13 31  4  0  0  0  0
 31 32  4  0  0  0  0
 10 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1482

>  <JC_XSMILES>
C1CCN(CC1)CCOC2=CC=C3C=C4C=CC(OCCN5CCCCC5)=CC4=NC3=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.348

>  <W2 Pf proliferation inhibition EC50 uM>
0.772

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.026785714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1487
  Mrv1591402191617072D          

 29 30  0  0  0  0            999 V2000
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1487

>  <JC_XSMILES>
CCOC(=O)N1CCN(CC1)C(=O)C(=O)NNC(=O)COC2=CC=C(Cl)C=C2Br

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.769

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-149
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.4290   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7146   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8580    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.3356   -0.8963    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5374    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -3.4105    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164   -4.8394    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 15 20  4  0  0  0  0
  8 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
  6 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
M  CHG  4   1  -1   2   1  21   1  22  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-149

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(=CC(=C1SC2=CC=CC3=CC=CN=C23)[N+]([O-])=O)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
4.34

>  <W2 Pf proliferation inhibition EC50 uM>
1.119

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.34

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1490
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    5.7158    3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8908    2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.5408    2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743    0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
  7 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 23 33  4  0  0  0  0
 27 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1490

>  <JC_XSMILES>
FC(F)(F)C1=CC(=CC(=C1)C(F)(F)F)C(=O)NCCCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.642

>  <W2 Pf proliferation inhibition EC50 uM>
0.766

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1491
  Mrv1591402191617072D          

 18 21  0  0  0  0            999 V2000
    1.4229   -2.4457    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464    0.7035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4609    1.1160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8734    1.8305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2859    1.1160    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 10  1  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  5 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1491

>  <JC_XSMILES>
BrC1=CC=C2N(CC3CO3)C4=CC=CC=C4C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.73

>  <W2 Pf proliferation inhibition EC50 uM>
2.249

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
29.37

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1493
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  3 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
  2 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  2  0  0  0  0
 29 31  4  0  0  0  0
 21 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 35 37  4  0  0  0  0
 37 38  4  0  0  0  0
 32 38  4  0  0  0  0
 38 39  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1493

>  <JC_XSMILES>
CC(N(CCC1=CC=CC=C1)C(=O)C2=CC=CC(F)=C2)C3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C)C=C5C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.764

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009433962

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1494
  Mrv1591402191617072D          

 31 36  0  0  0  0            999 V2000
    0.9497    1.3045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5597    0.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2649    0.5517    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6995    1.2530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3095    1.9800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7441    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5687    2.6554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1396    3.2510    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8824    2.8921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7706    2.0747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9587    1.9284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5241    1.2272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9141    0.5002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4795   -0.2010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6549   -0.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2203   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6043   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9943   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8189   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2535   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0781   -0.7735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -1.4747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3140   -1.2781    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3745   -0.4553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6108   -0.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1228   -2.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2982   -2.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8636   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0390   -1.5520    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.6490   -2.2790    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1756   -2.3048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  7 11  4  0  0  0  0
 11 12  4  0  0  0  0
  4 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
  3 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  4  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
 22 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
 28 29  4  0  0  0  0
 17 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
M  CHG  1  29   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1494

>  <JC_XSMILES>
CCn1c2ccc3occc3c2ccc1=CC4=CC=C5C6=C(OC=C6)C=CC5=[N+]4CC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.534

>  <W2 Pf proliferation inhibition EC50 uM>
0.764

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.285714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1496
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -3.6600   -1.0802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3744   -1.4927    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3744   -2.3177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6600   -2.7302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6600   -3.5552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3744   -3.9677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3744   -4.7927    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0889   -5.2052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0889   -3.5552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0889   -2.7302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8034   -3.9677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8034   -4.7927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5178   -5.2052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2323   -4.7927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9468   -5.2052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2323   -3.9677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9468   -3.5552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.6613   -3.9677    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -9.3757   -3.5552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0902   -3.9677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.3724   -3.1924    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -9.5599   -4.5996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.8421   -5.3749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.6545   -5.5181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.1848   -4.8862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.9027   -4.1109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5178   -3.5552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 20 26  1  0  0  0  0
 16 27  4  0  0  0  0
 11 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1496

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CNCC3(O)CCCCC3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.818

>  <W2 Pf proliferation inhibition EC50 uM>
0.762

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017094017

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1497
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.1067   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4888   -1.5291    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -3.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1661   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9866   -3.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -2.9774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8372   -2.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0168   -2.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 13 21  4  0  0  0  0
  9 21  4  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1497

>  <JC_XSMILES>
CCC1=CC=CC=C1N2C(=O)CN(CC3=CC=CC=C3)C2=S

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
6

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
78.8

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1498
  Mrv1591402191617072D          

 48 54  0  0  0  0            999 V2000
    4.6670   -1.9690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9525   -1.5565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9525   -0.7315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6670   -0.3190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3815   -0.7315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3815   -1.5565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6670    0.5060    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9525    0.9185    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
    4.4828    1.5505    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2953    1.4072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8256    2.0392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6380    1.8960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9202    1.1207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3899    0.4887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5774    0.6320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6704    0.1433    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
    3.1401   -0.7752    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6098   -1.4072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8919   -2.1825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3616   -2.8145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5492   -2.6712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2670   -1.8960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7973   -1.2640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3276    0.6320    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6098    1.4072    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
    1.7973    1.5505    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5151    2.3257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7027    2.4690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4205    3.2442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9508    3.8762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7633    3.7330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0454    2.9577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6098    2.2322    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3242    2.6447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3242    3.4697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0387    3.8822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7532    3.4697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7532    2.6447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0387    2.2322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4222    1.5505    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
  8 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 17 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
 17 32  2  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 35 40  1  0  0  0  0
 33 41  1  0  0  0  0
 41 42  1  0  0  0  0
 42 43  1  0  0  0  0
 43 44  1  0  0  0  0
 44 45  1  0  0  0  0
 45 46  1  0  0  0  0
 46 47  1  0  0  0  0
 42 47  1  0  0  0  0
 33 48  2  0  0  0  0
  8 48  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1498

>  <JC_XSMILES>
C1CCC(CC1)NP3(NC2CCCCC2)=NP(NC4CCCCC4)(NC5CCCCC5)=NP(NC6CCCCC6)(NC7CCCCC7)=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
6.61

>  <W2 Pf proliferation inhibition EC50 uM>
3.149

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
41.36

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1499
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 11 10  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 10 23  4  0  0  0  0
  5 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1499

>  <JC_XSMILES>
CC(C)(C)C1=CC(Br)=CC(C=NNC2=CC=C(C=C2)[N+]([O-])=O)=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.206

>  <W2 Pf proliferation inhibition EC50 uM>
0.761

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-150
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    1.3222   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    1.5884    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4888   -1.5291    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -3.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1661   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9866   -3.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -2.9774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8372   -2.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0168   -2.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  3  0  0  0  0
  2  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 10 18  4  0  0  0  0
  6 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-150

>  <JC_XSMILES>
NC(=NC#N)C1=C(N)N=C(NC2=CC=CC=C2)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.806

>  <W2 Pf proliferation inhibition EC50 uM>
2.39

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.37

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1502
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -1.6448   -1.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9303   -1.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2159   -1.4971    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4986   -1.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2131   -1.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9275   -1.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9275   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6420   -3.1471    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3565   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3565   -1.9096    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0709   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0709   -3.9721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7854   -2.7346    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.4999   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2536   -2.8116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8056   -3.4247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6306   -3.4247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0431   -4.1392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6306   -4.8536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8056   -4.8536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3931   -4.1392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5861   -3.9676    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2131   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4986   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
  7 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  22
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1502

>  <JC_XSMILES>
CCOC1=CC=C(NC(=O)C(C)SC2=NC3=CC=CC=C3N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>7.6

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1503
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 10 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
  8 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1503

>  <JC_XSMILES>
NC1=CC=C(C=C1)C2=NC(C3=CC=C(N)C=C3)=C4C=CC=CC4=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.759

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1505
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.8018   -4.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498   -4.0609    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736   -2.1486    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1487   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5612    0.4595    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3862    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7987    1.1740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6237    1.1740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0362    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0362   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7987   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  3  9  4  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 18 24  4  0  0  0  0
 15 25  4  0  0  0  0
 25 26  4  0  0  0  0
 10 26  4  0  0  0  0
 13 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1505

>  <JC_XSMILES>
COC1=CC=C(C(O)=C1)C2=CSC3=NC(COC4=CC=CC(C)=C4)=NN23

>  <PF proliferation inhibition 3D7 EC50 uM>
>4.62

>  <W2 Pf proliferation inhibition EC50 uM>
7.59

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1511
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
   -3.1034   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 10 18  4  0  0  0  0
 18 19  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  13
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1511

>  <JC_XSMILES>
CC1=CC=CC(=C1)C2=NN3C(=C2)N=C(C)C(C)=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.72

>  <W2 Pf proliferation inhibition EC50 uM>
7.54

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1512
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
  7 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1512

>  <JC_XSMILES>
CCCCCCN(C(C)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3OCC)C(=O)NC4=CC=CC=C4OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.852

>  <W2 Pf proliferation inhibition EC50 uM>
0.753

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1513
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1839   -0.0769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7359   -0.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3234   -1.4045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5165   -1.2330    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5253   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1904   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
  7 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 20 24  1  0  0  0  0
 19 25  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1513

>  <JC_XSMILES>
COC1=CC2=NC(CN(C)C(C)C3=CC=CS3)=NC(N4CCCC4)=C2C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.986

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
26.4

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1519
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 16 28  4  0  0  0  0
 11 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1519

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CNCCC3=CC=C(Cl)C=C3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.987

>  <W2 Pf proliferation inhibition EC50 uM>
0.749

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.043103448

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1520
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0470   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7376   -3.9425    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105   -5.6965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -6.4110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -6.4110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5395   -5.6965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3819   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1665   -3.9425    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 13 14  1  0  0  0  0
  5 14  1  0  0  0  0
 14 15  2  0  0  0  0
  2 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 16 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1520

>  <JC_XSMILES>
O=C(CCN1C(=O)C2CCCCC2C1=O)N3CCC4=CC=CC=C4C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>4.85

>  <W2 Pf proliferation inhibition EC50 uM>
7.49

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1522
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.0177   -1.9520    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427   -0.5230    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 30 33  1  0  0  0  0
  5 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 39 40  4  0  0  0  0
  3 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1522

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=C(Cl)C=C2)C(=O)NC3=CC=CC(=C3)C(F)(F)F)=C4N=CC=CC4=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.798

>  <W2 Pf proliferation inhibition EC50 uM>
0.332

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>4.44

>  <Powder data?>
No

>  <IFI value>
0.027027027

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1524
  Mrv1591402191617072D          

 47 52  0  0  0  0            999 V2000
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -6.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7638   -6.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3513   -5.5836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7638   -4.8691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -4.8691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.5836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -7.7270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388   -7.7270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6513   -8.4414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388   -9.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -9.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.4414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 16 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 16 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 39 41  2  0  0  0  0
 37 42  4  0  0  0  0
 42 43  4  0  0  0  0
 34 43  4  0  0  0  0
 32 44  4  0  0  0  0
 44 45  4  0  0  0  0
 29 45  4  0  0  0  0
  8 46  4  0  0  0  0
 46 47  4  0  0  0  0
  5 47  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1524

>  <JC_XSMILES>
CC(=O)NC1=CC=C(OC2=CC=C(C=C2)C(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=C(OC6=CC=C(NC(C)=O)C=C6)C=C5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.36

>  <W2 Pf proliferation inhibition EC50 uM>
0.747

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.015625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1525
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    5.3501   -2.4848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1602   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7003   -2.0171    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9703   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5104   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0505   -1.5493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8606   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4007   -1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1307   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2109   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7510   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4809    0.1657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0210    0.7893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8311    0.6334    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1012   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9113   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1814   -1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6413   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8311   -1.5493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5611   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9113   -2.4848    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   13.7214   -2.6407    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   12.3712   -3.1084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
M  CHG  2  22   1  23  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1525

>  <JC_XSMILES>
CCN(CC)CCCC(C)NC1=CC=NC2=CC=C(C=C12)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.249

>  <W2 Pf proliferation inhibition EC50 uM>
0.747

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1527
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -9.9000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -7.8592  -10.3125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -7.1447   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
 14 28  4  0  0  0  0
 28 29  4  0  0  0  0
 10 29  4  0  0  0  0
  7 30  4  0  0  0  0
  2 30  4  0  0  0  0
M  CHG  2  25   1  26  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1527

>  <JC_XSMILES>
CC1=CC(C)=NC(SCC2=CC(=O)C(OC(=O)C3=CC=CC(=C3C)[N+]([O-])=O)=CO2)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>7.47

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1529
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 17 27  4  0  0  0  0
 27 28  4  0  0  0  0
 14 28  4  0  0  0  0
 28 29  4  0  0  0  0
 12 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1529

>  <JC_XSMILES>
CC1=CC=CC=C1OCCSC2=NC3=CC=C(NC(=O)C4=CC=CC=C4)C=C3S2

>  <PF proliferation inhibition 3D7 EC50 uM>
9.76

>  <W2 Pf proliferation inhibition EC50 uM>
>7.47

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-153
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  2  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  5 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-153

>  <JC_XSMILES>
CC(=O)NN1C(=O)C2=CC=CC=C2N=C1C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.473

>  <W2 Pf proliferation inhibition EC50 uM>
2.467

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1531
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    1.6017   -6.3079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7947   -6.4794    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2427   -5.8663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5643   -6.0379    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4976   -5.0817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0127   -4.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8123   -4.4143    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2248   -3.6998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8123   -2.9853    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0498   -3.6998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4623   -4.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2873   -4.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6998   -5.1288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5248   -5.1288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9373   -4.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5248   -3.6998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6998   -3.6998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2873   -2.9853    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4623   -2.9853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0498   -2.2709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4976   -3.7468    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2822   -4.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2822   -4.8268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9967   -5.2393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7112   -4.8268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7112   -4.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4256   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9967   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  2  0  0  0  0
  6 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  5 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 22 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1531

>  <JC_XSMILES>
COC(=O)C1=C(NC(=O)C2=CC3=CC=CC=C3OC2=O)SC4=C1CCC(C)C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>7.46

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1536
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -0.0081   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7064   -2.5896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7064   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4208   -1.3521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1353   -2.5896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8498   -1.3521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8498   -0.5271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2787   -1.3521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9932   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7077   -1.3521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7939   -0.5316    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6009   -0.3601    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0134   -1.0745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8338   -1.1608    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.3188   -0.4933    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1393   -0.5796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6242    0.0879    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    9.4748   -1.3332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4613   -1.6876    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6329   -2.4946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4175   -2.7495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5890   -3.5565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9759   -4.1086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1474   -4.9155    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.1913   -3.8536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0198   -3.0466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 16 22  4  0  0  0  0
 13 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1536

>  <JC_XSMILES>
CC1=CC=C(C=C1)C(=O)NCCC2=NN=C(SCC(Cl)=C)N2C3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
7.43

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.017241379

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1537
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
   -2.5804   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1679   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5804   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3429   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -2.6029    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -2.7604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1129   -0.4834    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5609    0.1297    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 12 14  4  0  0  0  0
  8 14  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  1  0  0  0  0
  4 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  4  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1537

>  <JC_XSMILES>
CC(C)C1OC2=CC3=C(C=CC(=O)O3)C=C2C1=NO

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.147

>  <W2 Pf proliferation inhibition EC50 uM>
0.743

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-154
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1118    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 13 22  2  0  0  0  0
 22 23  1  0  0  0  0
  7 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-154

>  <JC_XSMILES>
NC(=O)C1=CC=C2CN(C3CC3)C(\C=C\C4=CC=CC=C4)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0747

>  <W2 Pf proliferation inhibition EC50 uM>
5.6

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
22.95

>  <Powder data?>
Yes

>  <IFI value>
0.074074074

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1541
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
  6 18  4  0  0  0  0
  4 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
  2 25  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1541

>  <JC_XSMILES>
OC1=CC(=NC2=CC=C(CC3=CC=NC=C3)C=C2)C4=CC=CC=C4C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.496

>  <W2 Pf proliferation inhibition EC50 uM>
0.739

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1544
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  8 16  4  0  0  0  0
 16 17  4  0  0  0  0
  5 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1544

>  <JC_XSMILES>
NC(=O)OC1=CC=C(CC2=CC=CC=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.843

>  <W2 Pf proliferation inhibition EC50 uM>
0.738

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1545
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    0.6411   -3.5854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3429   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1545

>  <JC_XSMILES>
N=C1C2=C(CCCC2)N(CC3=CC=CC=C3)C4=C1CCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.426

>  <W2 Pf proliferation inhibition EC50 uM>
0.738

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1546
  Mrv1591402191617072D          

 12 13  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
  7 12  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1546

>  <JC_XSMILES>
NC1=NC(Cl)=NC2=CC=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.516

>  <W2 Pf proliferation inhibition EC50 uM>
0.737

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.00625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1547
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4760    0.0724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309    0.8570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559    0.8570    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8109    0.0724    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5955   -0.1825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2086    0.3695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9932    0.1146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1647   -0.6924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5516   -1.2444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7670   -0.9895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1539   -1.5415    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.2460    1.5245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7611    2.1919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9134    2.0094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5786    1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 11 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  4 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1547

>  <JC_XSMILES>
CC(C)N(CC(=O)NC1=CC(=NN1C2=CC=CC=C2Cl)C(C)(C)C)C(=O)C3=CC=CC=C3C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.089

>  <W2 Pf proliferation inhibition EC50 uM>
0.649

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.81

>  <Powder data?>
No

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1548
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    3.3733   -3.1356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0877   -3.5481    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8022   -3.1356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8022   -2.3106    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5167   -3.5481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2312   -3.1356    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.9456   -3.5481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9456   -4.3731    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6601   -4.7856    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3746   -4.3731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3746   -3.5481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1592   -3.2931    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.6441   -3.9606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4646   -4.0468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9495   -3.3793    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.6140   -2.6257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8001   -4.8005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3152   -5.4679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4947   -5.3817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0098   -6.0491    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    9.1592   -4.6280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6601   -3.1356    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 10 21  4  0  0  0  0
 13 21  4  0  0  0  0
 11 22  4  0  0  0  0
  7 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1548

>  <JC_XSMILES>
COC(=O)CSC1=NN=C2C(NC3=C(OC)C=CC(Cl)=C23)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.642

>  <W2 Pf proliferation inhibition EC50 uM>
0.736

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.031914894

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1555
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -13.6125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 22 23  4  0  0  0  0
 16 23  4  0  0  0  0
 12 24  4  0  0  0  0
  8 24  4  0  0  0  0
 24 25  2  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1555

>  <JC_XSMILES>
COC1=CC=C(CN2C=CC=C(C(=O)NC3=CC=C(OC)C=C3)C2=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.111

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
42.54

>  <Powder data?>
Yes

>  <IFI value>
0.052631579

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1556
  Mrv1591402191617072D          

 38 40  0  0  0  0            999 V2000
   -6.4302   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -7.0125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7474   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3974   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
  8 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 36 38  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1556

>  <JC_XSMILES>
COC1=CC(OC)=C(C=C1Cl)N(C)S(=O)(=O)C2=CC=CC(=C2)C(=O)OCC(=O)NC3=CC=CC=C3C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
8.4

>  <W2 Pf proliferation inhibition EC50 uM>
7.31

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.096774194

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1558
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  2  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
  9 23  4  0  0  0  0
  3 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1558

>  <JC_XSMILES>
CCC1=CC(=O)N(C)C(SC(C)C(=O)NC2=CC=C(F)C=C2)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.756

>  <W2 Pf proliferation inhibition EC50 uM>
0.729

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.031578947

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-156
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 10 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 21 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 19 30  4  0  0  0  0
 30 31  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  29
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-156

>  <JC_XSMILES>
CN(C)CCCNC(=S)N(CC1=CC=CC=C1)CC2=CC3=C(C)C=CC(C)=C3NC2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
5.22

>  <W2 Pf proliferation inhibition EC50 uM>
>4.67

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.53

>  <Powder data?>
Yes

>  <IFI value>
0.06185567

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1561
  Mrv1591402191617072D          

 32 37  0  0  0  0            999 V2000
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  4 17  4  0  0  0  0
 12 17  4  0  0  0  0
  1 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 19 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1561

>  <JC_XSMILES>
C(CNC1=C2C=CC=CC2=NC3=CC=CC=C13)NC4=C5C=CC=CC5=NC6=CC=CC=C46

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0829

>  <W2 Pf proliferation inhibition EC50 uM>
0.858

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.78

>  <Powder data?>
Yes

>  <IFI value>
0.073170732

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1567
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    3.5724   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  5 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1567

>  <JC_XSMILES>
ClC1=CC=C(CCNC2CCN(CC2)CCC3=CC=CC=C3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1502

>  <W2 Pf proliferation inhibition EC50 uM>
0.696

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.6

>  <Powder data?>
Yes

>  <IFI value>
0.015748031

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-157
  Mrv1591402191617072D          

 14 14  0  0  1  0            999 V2000
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  4  2  1  1  0  0  0
  4  5  1  0  0  0  0
  6  5  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  1  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-157

>  <JC_XSMILES>
OC(=O)[C@H]1C[C@H](CCN1)CP(O)(O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.317

>  <W2 Pf proliferation inhibition EC50 uM>
>1.208

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>5.06

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1573
  Mrv1591402191617072D          

 16 18  0  0  0  0            999 V2000
   -3.0091   -0.1648    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2021    0.0067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9471    0.7913    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6501   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9050   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3530   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5460   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1215   -2.3175    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7889   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5340   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0860   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8930   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1479   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5959   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2910   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8431   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  4  0  0  0  0
  7 15  4  0  0  0  0
 15 16  4  0  0  0  0
  4 16  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1573

>  <JC_XSMILES>
NC(=O)C1=CC=C2NC3=C(CCCC3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>7.16

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1577
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 11 17  4  0  0  0  0
  4 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  2 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  3  0  0  0  0
 18 23  1  0  0  0  0
 23 24  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1577

>  <JC_XSMILES>
NC1=NC(N2CCN(CC2)C3=CC=CC(Cl)=N3)=C(C=C1C#N)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.791

>  <W2 Pf proliferation inhibition EC50 uM>
0.714

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.065789474

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1578
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 17 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1578

>  <JC_XSMILES>
FC1=CC=C(C=C1)S(=O)(=O)NCCCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.341

>  <W2 Pf proliferation inhibition EC50 uM>
0.713

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1581
  Mrv1591402191617072D          

 18 18  0  0  0  0            999 V2000
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    0.3020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -1.1270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -1.1270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    0.3020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
  7 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1581

>  <JC_XSMILES>
CC(=O)NC1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.314

>  <W2 Pf proliferation inhibition EC50 uM>
0.711

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1582
  Mrv1591402191617072D          

 37 40  0  0  1  0            999 V2000
    6.5019    0.6415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7617    1.1261    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.6110    0.3150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7931    0.2076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4382    0.9523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6200    1.3340    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.9653    0.8320    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9804   -0.0245    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2032    1.1480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5240    0.6259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0958    1.9660    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.2708    2.1983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7505    2.4680    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8155    3.2904    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1244    3.8244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3390    4.6375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7534    5.2187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9639    6.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7600    6.2329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3456    5.6518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1351    4.8541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6178    3.4827    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8173    2.8097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7606    2.9101    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5126    2.1520    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.1673    2.6540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2875    3.6357    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301    4.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5264    5.0873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6462    4.1996    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9294    2.3380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5841    2.8400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3462    2.5240    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.8204    3.2613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2327    2.5624    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4536    1.7060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3325    1.5380    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  4  3  1  4  0  0  0
  4  5  2  0  0  0  0
  6  5  1  1  0  0  0
  6  7  1  0  0  0  0
  7  8  1  6  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 11  9  1  0  0  0  0
 11 12  1  1  0  0  0
 13 11  1  0  0  0  0
 13 14  1  1  0  0  0
 14 15  1  6  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 14 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 25 23  1  1  0  0  0
 25  6  1  0  0  0  0
 13 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  2  0  0  0  0
 31 26  1  4  0  0  0
 31 32  2  0  0  0  0
 33 32  1  0  0  0  0
 33 34  1  6  0  0  0
 33 35  1  1  0  0  0
 33 36  1  0  0  0  0
  2 36  1  0  0  0  0
 36 37  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1582

>  <JC_XSMILES>
C[C@H]1CC=C[C@H]2[C@H](O)C(=C)[C@@H](C)[C@H]3[C@H](CC4=CC=CC=C4)NC(=O)[C@@]23C(OC(C)=O)C=C[C@@](C)(O)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.17

>  <W2 Pf proliferation inhibition EC50 uM>
0.711

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.068965517

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1583
  Mrv1591402191617072D          

 15 16  0  0  0  0            999 V2000
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
  5 14  4  0  0  0  0
 14 15  4  0  0  0  0
  2 15  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1583

>  <JC_XSMILES>
NC1=CC=C(NC2=CC=C(N)C=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.319

>  <W2 Pf proliferation inhibition EC50 uM>
0.711

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.039370079

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1586
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -1.5356    0.7634    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    2.4134    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078   -0.4741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5986   -3.9898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7479   -5.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9275   -5.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4425   -4.8297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7781   -4.0760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  2  0  0  0  0
 14 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
  7 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1586

>  <JC_XSMILES>
ClC1=CC=C(Cl)C(NC(=O)CC2SC(NC2=O)=NC3=CC=CC=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>7.08

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034482759

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1588
  Mrv1591402191617072D          

 36 38  0  0  0  0            999 V2000
   -2.9114   -3.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1969   -3.0012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4824   -3.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7680   -3.0012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0535   -3.4137    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6610   -3.0012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6610   -2.1762    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3755   -3.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0899   -3.0012    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0283   -2.1785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2603   -1.8771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1373   -1.0613    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6330   -1.6173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3899   -0.8290    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4488   -1.7403    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8613   -2.4548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6771   -2.3318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1915   -2.9768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8901   -3.7448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4045   -4.3898    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1031   -5.1578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6174   -5.8028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3160   -6.5708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8304   -7.2158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0743   -3.8677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5599   -3.2227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7716   -3.4659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6486   -4.2817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3755   -4.2387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0899   -4.6512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0899   -5.4762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3755   -5.8887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6610   -5.4762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0535   -5.8887    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7680   -5.4762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6610   -4.6512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 25  4  0  0  0  0
 25 26  4  0  0  0  0
 16 26  4  0  0  0  0
 26 27  1  0  0  0  0
  9 27  1  0  0  0  0
 27 28  2  0  0  0  0
  8 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 29 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1588

>  <JC_XSMILES>
CCCCNC(=O)C(N1C(CO)C(=O)NC2=CC=C(OCCCC)C=C2C1=O)C3=CC=CC(OC)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2047

>  <W2 Pf proliferation inhibition EC50 uM>
0.1676

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>2.37

>  <Powder data?>
No

>  <IFI value>
0.009803922

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-159
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  5 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  2  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
  3 23  4  0  0  0  0
 15 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-159

>  <JC_XSMILES>
CCN1N=C(\C=C\C2=CC=CC=C2)N=C3C(=O)N(C)C(=O)N=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
>3.33

>  <W2 Pf proliferation inhibition EC50 uM>
>10

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
42.03

>  <Powder data?>
Yes

>  <IFI value>
0.166666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1598
  Mrv1591402191617072D          

 42 45  0  0  0  0            999 V2000
   -1.7946   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5246   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -0.8802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -1.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -1.3480    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    0.0552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9058   -0.1007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3657    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444    0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9845    0.9907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.7702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0957    1.9262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358    1.3025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459    1.4584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    2.2380    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860    0.8348    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961    0.9907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362    0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164    1.3025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763    1.9262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662    1.7702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261    2.3939    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961    3.1734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261   -1.9716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -1.8157    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -2.7512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961   -3.3748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261   -4.1543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -4.3103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459   -5.0898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -5.2457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3657   -6.0253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444   -6.1812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.9607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -3.6866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459   -2.9071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
  7 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 35 41  4  0  0  0  0
 41 42  4  0  0  0  0
 32 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1598

>  <JC_XSMILES>
CCCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3OC)C(=O)C4=CC=C(CCCCC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.03

>  <W2 Pf proliferation inhibition EC50 uM>
0.699

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019417476

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1599
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
   -7.0380   -4.3098    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -5.1348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3706   -5.6197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6255   -6.4044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4505   -6.4044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7054   -5.6197    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4901   -5.3648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.1032   -5.9168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.9316   -6.7238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.5447   -7.2758    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -9.3732   -8.0828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5886   -8.3378    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -9.9863   -8.6348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.8148   -9.4418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.4279   -9.9938    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -11.2125   -9.7389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.3840   -8.9319    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7709   -8.3799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.9424   -7.5729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.3293   -7.0209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.5009   -6.2139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.2855   -5.9590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.8986   -6.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.6832   -6.2561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.8547   -5.4491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.2416   -4.8971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4570   -5.1520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.8256  -10.2909    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -11.6541  -11.0979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.2671  -11.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -13.0518  -11.3950    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -13.2233  -10.5880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.6102  -10.0360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -13.6649  -11.9470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -13.4933  -12.7540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.7087  -13.0090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.5372  -13.8159    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -13.1503  -14.3680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -13.9349  -14.1130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -14.1064  -13.3060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  2  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 16 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
 31 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 35 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1599

>  <JC_XSMILES>
O=C1CCCN1CCCNC(=O)C2=CN=C(N=C2NCCC3=CC=CC=C3)N4CCN(CC4)CC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.572

>  <W2 Pf proliferation inhibition EC50 uM>
0.699

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009803922

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-160
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    4.0668    3.7769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6543    3.0624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4793    1.6335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    2.2374    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -0.5422    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -0.1006    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 13 24  4  0  0  0  0
  9 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-160

>  <JC_XSMILES>
CCC(C)(C)C1CCC2=C(C1)SC(NC(=O)C3=CC=C(F)C=C3)=C2C(N)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
2.336

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1606
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
  7 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  1  0  0  0  0
 36 38  4  0  0  0  0
 32 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1606

>  <JC_XSMILES>
CCCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3OC)C(=O)C4=CC=CC(F)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.071

>  <W2 Pf proliferation inhibition EC50 uM>
0.509

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>7.32

>  <Powder data?>
No

>  <IFI value>
0.027272727

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1609
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -0.2133    3.1329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0919    2.3168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6754    2.0139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7967    1.1979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1507    0.6848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3003   -0.3217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3882   -0.0297    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6577    1.0482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8955    0.7325    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5797   -0.0297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8955   -0.7919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6577   -1.1076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4199   -0.7919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7356   -0.0297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4199    0.7325    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6372   -0.0248    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1189   -0.7291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7621   -1.4729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9415   -0.6662    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4073   -1.3472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2299   -1.2843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6957   -1.9652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3388   -2.7090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5162   -2.7719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1594   -3.5158    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0505   -2.0910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6167    0.9877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7380    1.8038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
  8 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 20 26  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1609

>  <JC_XSMILES>
CC1=CC=C(CN2C3CCCC2CC(C3)NC(=O)NC4=CC=CC(F)=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.898

>  <W2 Pf proliferation inhibition EC50 uM>
0.695

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.013157895

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-161
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    3.4935   -2.0596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -1.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -0.8221    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -0.4096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225    0.4154    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -0.8221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3514   -0.4096    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4377    0.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8246    0.9629    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2446    0.5824    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6571   -0.1320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4641   -0.3036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7190   -1.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1670   -1.7013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3600   -1.5298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1051   -0.7451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935   -0.4096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791   -0.8221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0646   -0.4096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0646    0.4154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3501    0.8279    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791    0.8279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935    0.4154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  2  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  7 16  4  0  0  0  0
 11 16  4  0  0  0  0
  3 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-161

>  <JC_XSMILES>
CCN(C(=O)CN1C(=O)OC2=CC=CC=C12)C3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.526

>  <W2 Pf proliferation inhibition EC50 uM>
2.306

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1610
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 18 24  1  0  0  0  0
 24 25  1  0  0  0  0
 15 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1610

>  <JC_XSMILES>
COC1=CN=CC(=C1)C2=CN=CC(=N2)N3CCN(CCN(C)C)CC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2611

>  <W2 Pf proliferation inhibition EC50 uM>
0.695

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1611
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    4.9524    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3454    2.4777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7044    2.0361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9594    2.8207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7663    2.9922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1019    3.7459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9224    3.6597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0939    2.8527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3794    2.4402    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 12  1  0  0  0  0
  3 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  2 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 13 24  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1611

>  <JC_XSMILES>
CC1=C(C(=O)NCC2CCCO2)C3=C(O1)C(=O)C4=CC=CC=C4C3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.185

>  <W2 Pf proliferation inhibition EC50 uM>
0.481

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.93

>  <Powder data?>
Yes

>  <IFI value>
0.170212766

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1614
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 20 30  1  0  0  0  0
 25 30  4  0  0  0  0
  6 31  4  0  0  0  0
  2 31  4  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1614

>  <JC_XSMILES>
CC1=CC=CC(NC2=CC=CC=C2C(=O)OCC(=O)N3CC(=O)NC4=CC=CC=C34)=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
4.71

>  <W2 Pf proliferation inhibition EC50 uM>
3.82

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
55.09

>  <Powder data?>
Yes

>  <IFI value>
0.043478261

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1619
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
    8.1631    5.2467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3507    5.1035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0685    4.3282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2560    4.1850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7257    4.8169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9133    4.6737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6311    3.8984    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1614    3.2664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8792    2.4912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3489    1.5727    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5365    2.9799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8186    3.7552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -0.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -0.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    1.5229    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0079    5.5922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8204    5.7354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 19 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 28 34  4  0  0  0  0
  5 35  4  0  0  0  0
 35 36  4  0  0  0  0
  2 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1619

>  <JC_XSMILES>
CC1=CC=C(CN2CCC(O)(CC2)C3=CC=C4OC(=CC4=C3)C(=O)NCCC5=CC=CC(F)=C5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.16

>  <W2 Pf proliferation inhibition EC50 uM>
3.011

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
43.53

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-162
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
  7 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-162

>  <JC_XSMILES>
COC1=CC=CC2=C1OCC(=C2)C(=O)NC3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.461

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
54.73

>  <Powder data?>
Yes

>  <IFI value>
0.114285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1620
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -1.4534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4520   -2.8329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1970   -3.6175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3720   -3.6175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1171   -2.8329    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.3646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1563    2.1850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9633    2.3566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3758    1.6421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8237    1.0290    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 10 17  1  0  0  0  0
  5 17  1  0  0  0  0
  8 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1620

>  <JC_XSMILES>
CC1=C(C)C2=C(S1)N(CN(CC3=CC=CO3)C2)C(=O)C4=CC=CO4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>6.91

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1622
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.8918   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2418   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  5 14  4  0  0  0  0
  9 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 15 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  2  0  0  0  0
 25 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1622

>  <JC_XSMILES>
COC(=O)C1=C(C)OC2=CC=C(C=C12)N(C(=O)C3=CC=C(C)C=C3)S(=O)(=O)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.68

>  <W2 Pf proliferation inhibition EC50 uM>
0.69

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1623
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
  5 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
 38 39  4  0  0  0  0
  3 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1623

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=CC=C2OC)C(=O)COCC3=CC=CC=C3)=C4N=CC=CC4=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.115

>  <W2 Pf proliferation inhibition EC50 uM>
0.689

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028037383

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1625
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 10 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1625

>  <JC_XSMILES>
CN1CCN(CC1)C2=CC(=NC(=N2)C3=CC=NC=C3)C4=CC=CN=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.588

>  <W2 Pf proliferation inhibition EC50 uM>
0.656

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>9.55

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1626
  Mrv1591402191617072D          

 29 34  0  0  0  0            999 V2000
   -2.0945   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3320   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7445   -1.0164    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.7445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3320    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0945    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2695    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0395   -1.0396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8520    0.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1375   -0.2750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5770    0.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4945    0.8800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1375    1.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8520    0.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0395    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 12 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 14 27  1  0  0  0  0
 22 27  4  0  0  0  0
 13 28  1  0  0  0  0
  9 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1626

>  <JC_XSMILES>
CC1=C(Cl)C=CC=C1N2C(=O)C3C(C4C5=CC=CC=C5C3C6=CC=CC=C46)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.61

>  <W2 Pf proliferation inhibition EC50 uM>
0.686

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1628
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 12 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 20 29  2  0  0  0  0
 29 30  1  0  0  0  0
 10 30  4  0  0  0  0
 30 31  4  0  0  0  0
  7 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1628

>  <JC_XSMILES>
CC(C)NC(=O)C1=CC=C2CN(CC3CCCCC3)C(\C=C\C4=CC=CC=C4)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.696

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.15

>  <Powder data?>
No

>  <IFI value>
0.061728395

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1637
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 13 20  4  0  0  0  0
 11 21  4  0  0  0  0
  6 21  4  0  0  0  0
 21 22  4  0  0  0  0
  3 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1637

>  <JC_XSMILES>
COC1=CC=C2N=C(C)C=C(NC3=CC=C(Cl)C(Cl)=C3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2491

>  <W2 Pf proliferation inhibition EC50 uM>
0.426

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.25

>  <Powder data?>
Yes

>  <IFI value>
0.119402985

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1639
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
  5 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1639

>  <JC_XSMILES>
OC1=CC=C(C=C1CNCCN2CCOCC2)C3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.901

>  <W2 Pf proliferation inhibition EC50 uM>
0.681

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008547009

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-164
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
  9 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 22 23  4  0  0  0  0
 16 23  4  0  0  0  0
 10 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 27 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-164

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2C(CCC(=O)N2C3=CC=C(OC)C=C3)C(=O)NC4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.362

>  <W2 Pf proliferation inhibition EC50 uM>
2.274

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1642
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 15 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
  7 33  4  0  0  0  0
  3 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1642

>  <JC_XSMILES>
COC1=CC=CC(CCN2CC3=CC=C(C=C3N=C2C4=CC=C(C)C=C4)C(=O)NC(C)C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.938

>  <W2 Pf proliferation inhibition EC50 uM>
0.68

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.036585366

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1643
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -5.0013    2.0625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -4.2868    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 16 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
M  CHG  4  19   1  20  -1  22   1  23  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1643

>  <JC_XSMILES>
NC(=O)C(CC1=CC=CC=C1)NC2=CC=C(C=C2[N+]([O-])=O)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.883

>  <W2 Pf proliferation inhibition EC50 uM>
0.68

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1649
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    2.4549    1.6515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9398    0.9841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7648    0.9841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0197    0.1995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6848    0.1995    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5983   -0.4834    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.5433   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -1.2210    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -2.6499    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1067   -3.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9317   -3.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3442   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1692   -2.6499    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.9317   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1067   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1649

>  <JC_XSMILES>
CC1=CC=C(O1)C2=C3CCCCC3=NC4=C2C(N)=C(S4)C(=O)NC5=CC=C(Cl)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
8.31

>  <W2 Pf proliferation inhibition EC50 uM>
6.78

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022988506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1651
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309    1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 12 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 10 29  1  0  0  0  0
 29 30  2  0  0  0  0
  8 31  4  0  0  0  0
 31 32  4  0  0  0  0
  5 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1651

>  <JC_XSMILES>
CC(=O)NC1=CC=C(NC2=CC(=NS(=O)(=O)C3=CC=CC=C3)C4=CC=CC=C4C2=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.509

>  <W2 Pf proliferation inhibition EC50 uM>
0.466

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.88

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1652
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    3.6664    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.8837    3.6664    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.6462    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
  7 19  4  0  0  0  0
 19 20  4  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
 21 22  2  0  0  0  0
M  CHG  2  16   1  17  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1652

>  <JC_XSMILES>
CC1=NN=C2SC(SCC3=CC=CC(=C3)[N+]([O-])=O)=NN2C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.071

>  <W2 Pf proliferation inhibition EC50 uM>
0.942

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>13.91

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1657
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 27 33  4  0  0  0  0
 14 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 12 36  4  0  0  0  0
 36 37  4  0  0  0  0
  8 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1657

>  <JC_XSMILES>
CN1CCN(CC1)C2=CC(C)=C3C=C(NC(=S)NCC4CCN(CC4)CC5=CC=CC(C)=C5)C=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.9

>  <W2 Pf proliferation inhibition EC50 uM>
6.76

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1658
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  7  6  1  4  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  4  0  0  0  0
  3 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1658

>  <JC_XSMILES>
COC1=CC=C(C=NNC2=CC(C)=NC(=N2)C3=CC=CC=C3)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
8.51

>  <W2 Pf proliferation inhibition EC50 uM>
3.3

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.85

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-166
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2309    5.7705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0379    5.9420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4504    5.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8984    4.6144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  1  0  0  0  0
  6 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-166

>  <JC_XSMILES>
ClC1=CC=C2C(NC3CCC(CC3)NC(=O)CCC4CCCC4)=CC=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.014

>  <W2 Pf proliferation inhibition EC50 uM>
0.875

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>3.89

>  <Powder data?>
No

>  <IFI value>
0.009009009

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1662
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    4.5450   -2.9890    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.9930   -3.6021    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.1860   -3.4305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2480   -4.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0549   -4.5582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3099   -5.3428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7578   -5.9559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9509   -5.7844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6959   -4.9998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8889   -4.8283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2759   -5.3803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5614   -4.9678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5534   -4.0746    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 15 13  1  4  0  0  0
 15 16  2  0  0  0  0
 17 16  1  4  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  1  0  0  0  0
 22 27  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1662

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC=C1C2=CC=C(O2)C=NN=C3C(=O)NC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
6.75

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1664
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 16 28  4  0  0  0  0
 11 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1664

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CNCC(C)C3=CC=CC=C3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.96

>  <W2 Pf proliferation inhibition EC50 uM>
0.672

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.035087719

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1669
  Mrv1591402191617072D          

 16 16  0  0  0  0            999 V2000
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    2.5855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1669

>  <JC_XSMILES>
CC(C)(C)NS(=O)(=O)C1=CC(Cl)=CC=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.73

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.94

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-167
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    6.9246    6.4729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7977    6.7749    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.6227    5.3460    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    6.4729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.7648    6.7749    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9398    5.3460    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
  7 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  5 23  4  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-167

>  <JC_XSMILES>
FC(F)(F)C1=CC(NC(=O)NC2=CC=C3N=NSC3=C2)=CC(=C1)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
6.37

>  <W2 Pf proliferation inhibition EC50 uM>
4.36

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.4

>  <Powder data?>
Yes

>  <IFI value>
0.128205128

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1671
  Mrv1591402191617072D          

 11 12  0  0  0  0            999 V2000
    2.5645    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  7 11  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  11
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1671

>  <JC_XSMILES>
NNC1=NC=NC2=C1N=CN2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3029

>  <W2 Pf proliferation inhibition EC50 uM>
0.666

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1672
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
  9 18  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1672

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2C(=O)C3=CC=CN=C3C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.982

>  <W2 Pf proliferation inhibition EC50 uM>
0.665

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.011494253

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1676
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -3.9849    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2704    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414    2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -0.1105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5395   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559   -0.5230    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9684    0.1914    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2704   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2704   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9849   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6993   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4138   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6993   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9849   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    2.3645    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.4125    3.1895    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.3020    1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 11 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
  6 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
M  CHG  2  24   1  25  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1676

>  <JC_XSMILES>
COC1=CC=C(C=C1N(CC2CO2)S(=O)(=O)C3=CC=C(C)C=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
6.64

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1677
  Mrv1591402191617072D          

 48 52  0  0  0  0            999 V2000
    5.2520    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    1.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    1.8414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    2.5559    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    4.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    5.4138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    4.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6827    2.6539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7642    2.1236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9475   -0.3882    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190   -1.1952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8727   -1.5307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5401   -1.0458    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9589   -2.3512    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7126   -2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4045   -1.6077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7914   -1.0556    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3183   -2.4282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5646   -2.7637    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9857   -2.9131    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8995   -3.7336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355   -1.0164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -1.7309    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    1.1270    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480    1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 10 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  2  0  0  0  0
  8 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 27 32  2  0  0  0  0
 32 33  1  0  0  0  0
 25 33  1  0  0  0  0
 32 34  1  0  0  0  0
 34 35  2  0  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 25 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  2  0  0  0  0
 39 41  1  0  0  0  0
 41 42  1  0  0  0  0
 38 43  2  0  0  0  0
 43 44  1  0  0  0  0
 23 44  1  0  0  0  0
 43 45  1  0  0  0  0
 45 46  2  0  0  0  0
 45 47  1  0  0  0  0
 47 48  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1677

>  <JC_XSMILES>
CCOC1=CC=CC2=C1N(C(=O)C3=CC=C(C)C=C3)C(C)(C)C4=C2C5(SC(C(=O)OC)=C(S5)C(=O)OC)C(C(=O)OC)=C(S4)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.082

>  <W2 Pf proliferation inhibition EC50 uM>
0.663

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-168
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -5.7158   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 15 26  4  0  0  0  0
 11 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-168

>  <JC_XSMILES>
O=C(NC1=CC=NC=C1)NC2=CC=CC(NC(=O)NC3=CC=NC=C3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
2.226

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1680
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -2.6039   -6.4440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6039   -5.6190    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8895   -5.2065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8895   -4.3815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1750   -3.9690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4605   -4.3815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2540   -3.9690    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9684   -4.3815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9684   -5.2065    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6829   -3.9690    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3974   -4.3815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1118   -3.9690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1981   -3.1485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0050   -2.9770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4175   -3.6915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8655   -4.3046    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0370   -5.1115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8217   -5.3665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4348   -4.8145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2194   -5.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3909   -5.8764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1755   -6.1313    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7778   -6.4284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9932   -6.1735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4605   -5.2065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1750   -5.6190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1750   -6.4440    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8895   -6.8565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
  6 25  4  0  0  0  0
 25 26  4  0  0  0  0
  3 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1680

>  <JC_XSMILES>
COC1=CC=C(NC(=O)NCC2=CC=CN2CC3=CC=C(F)C=C3)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.066

>  <W2 Pf proliferation inhibition EC50 uM>
0.661

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1683
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -1.4289   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5395   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 18 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1683

>  <JC_XSMILES>
CN(C)CC(C)(C)CNCC1=CC(=CC=C1O)C2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.88

>  <W2 Pf proliferation inhibition EC50 uM>
0.66

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.044247788

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1684
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
  7 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1684

>  <JC_XSMILES>
CCCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3OC)C(=O)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.054

>  <W2 Pf proliferation inhibition EC50 uM>
0.526

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>7.98

>  <Powder data?>
No

>  <IFI value>
0.010309278

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1687
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9441    3.2955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7511    3.4670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1636    2.7525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6116    2.1394    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
  9 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
  7 25  4  0  0  0  0
  5 26  4  0  0  0  0
 26 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1687

>  <JC_XSMILES>
CC1=CC=C(SC2=CC(C(=O)NCC3=CC=CO3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>6.98

>  <W2 Pf proliferation inhibition EC50 uM>
6.58

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011904762

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1688
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  3 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1688

>  <JC_XSMILES>
C1CN(CCC1NC\C=C\C2=CC=CC=C2)CC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.995

>  <W2 Pf proliferation inhibition EC50 uM>
0.657

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-169
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.7445    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4521   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0652   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8498   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0213   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4082   -1.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6236   -1.8980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8059   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5905   -1.6852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5510   -1.1555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0609   -2.7248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4521   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6236   -1.8980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0652   -3.2570    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8498   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0213   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8059   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4190   -2.4922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2475   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4629   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2913   -4.3611    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 12 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-169

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(=O)N2C(CSC2C3=CC=C(C=C3)C(C)(C)C)C(=O)NC4=CC=CC=C4F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.94

>  <W2 Pf proliferation inhibition EC50 uM>
0.801

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>3.6

>  <Powder data?>
No

>  <IFI value>
0.021505376

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1693
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    4.3613    1.2168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6601    0.7822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8963    1.0941    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3637    0.4640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7983   -0.2372    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5995   -0.0406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2295   -0.5732    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4083   -0.9642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8429   -1.6655    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6675   -1.6397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1021   -2.3409    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9267   -2.3152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3613   -3.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9713   -3.7434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4059   -4.4447    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.1467   -3.7692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7121   -3.0679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5837   -0.9900    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1491   -0.2887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3245   -0.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1101    0.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2799    1.1137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1045    1.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391    0.4383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  2  6  1  0  0  0  0
  6  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
  8 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  1  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1693

>  <JC_XSMILES>
CC1N=C2N(C1=O)C(SCC3=CC=C(F)C=C3)=NC4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>6.53

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1694
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    4.3418   -5.1784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7898   -4.5653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4029   -4.0132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1767   -5.1173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2377   -3.9522    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4927   -3.1676    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9406   -2.5545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1337   -2.7260    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1956   -1.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435   -1.1567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1694

>  <JC_XSMILES>
CC(C)(C)NCC(O)COC1=CC=CC2=C1C3=CC=CC=C3O2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.653

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1696
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    7.5449    4.1799    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    6.7245    4.0936    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.2395    4.7611    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3889    3.3400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8014    2.6255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2494    2.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5819    3.1684    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 17 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1696

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(O1)C(=O)NC2=CC=C3OC(=NC3=C2)C4=CC=C(I)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
3.161

>  <W2 Pf proliferation inhibition EC50 uM>
2.204

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
33.77

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1697
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5196   -0.3381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5196    0.4869    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 10 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
  9 27  1  0  0  0  0
M  CHG  2  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1697

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3[N+]([O-])=O)C(=O)CC(C)(C)C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
5.97

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>91.52

>  <Powder data?>
Yes

>  <IFI value>
0.022988506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1699
  Mrv1591402191617072D          

 24 24  0  0  0  0            999 V2000
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4623   -9.8712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8496   -9.2004    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
  7 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 16 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1699

>  <JC_XSMILES>
CN(C)CCCN(CCCN(C)C)CCC1=C(C)CCCC1(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.193

>  <W2 Pf proliferation inhibition EC50 uM>
0.498

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.66

>  <Powder data?>
Yes

>  <IFI value>
0.039370079

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1702
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
  9 21  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1702

>  <JC_XSMILES>
CCC(=O)N(C(C)C)C1=C(NC)C(=O)C2=CC=CC=C2C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00899

>  <W2 Pf proliferation inhibition EC50 uM>
0.0365

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.563

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1703
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1118    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
  7 15  4  0  0  0  0
 15 16  4  0  0  0  0
  4 16  4  0  0  0  0
 13 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1703

>  <JC_XSMILES>
NC(=O)C1=CC=C2CN(C3CC3)C(=NC2=C1)C4=CC=CN=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.295

>  <W2 Pf proliferation inhibition EC50 uM>
0.648

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.036585366

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1704
  Mrv1591402191617072D          

 48 55  0  0  0  0            999 V2000
    8.6607   10.9089    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    8.2482   10.1944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6607    9.4799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2482    8.7655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4232    8.7655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0107    9.4799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4232   10.1944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0107    8.0510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4232    7.3365    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0107    6.6221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4232    5.9076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0107    5.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1857    5.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7732    5.9076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1857    6.6221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7732    4.4787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1088    3.7250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9528    4.3924    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587    0.8085    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  8  5  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 21 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 28 32  4  0  0  0  0
 32 33  4  0  0  0  0
 25 33  4  0  0  0  0
 30 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 40 37  1  0  0  0  0
 40 41  2  0  0  0  0
 41 42  1  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  1  0  0  0  0
 45 47  4  0  0  0  0
 47 48  4  0  0  0  0
 42 48  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  24
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  31
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1704

>  <JC_XSMILES>
BrC1=CC=C(C=C1)C=NC2=CC=C(C=C2)C3=NC4=CC=C(C=C4N3)C5=CC=C6N=C(NC6=C5)C7=CC=C(C=C7)N=CC8=CC=C(Br)C=C8

>  <PF proliferation inhibition 3D7 EC50 uM>
0.587

>  <W2 Pf proliferation inhibition EC50 uM>
0.647

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.230769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1706
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.8744    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  4 12  1  0  0  0  0
  7 12  4  0  0  0  0
  5 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1706

>  <JC_XSMILES>
CC(=O)N1C(CC2=CC=CC=C12)C(=O)NCC3=CC=CC(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>6.46

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1707
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
    1.5983   -3.3875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5983   -0.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7913   -0.3119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5363    0.4728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0884    1.0859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8953    0.9143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4474    1.5274    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1503    0.1297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5433   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1067   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9317   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3442   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3442   -1.2210    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  2  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  2 15  1  0  0  0  0
  5 15  4  0  0  0  0
  4 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 16 22  4  0  0  0  0
  3 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1707

>  <JC_XSMILES>
CC1N(C(N2C(=O)C3=CC=CC=C3N=C12)C4=CC=CC(O)=C4)C5=CC=C(C=C5)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.054

>  <W2 Pf proliferation inhibition EC50 uM>
0.646

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1708
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 10 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
  5 26  4  0  0  0  0
 26 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1708

>  <JC_XSMILES>
CC1=CN=C(CNC2=CC(=NC(=N2)C3=CC=CC=N3)C4=CC=CC=N4)N=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.465

>  <W2 Pf proliferation inhibition EC50 uM>
0.646

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.117647059

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1709
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -1.3333   -0.8607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8734   -1.4843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6033   -2.2639    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9535   -2.7316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7932   -2.4198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2531   -1.7961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5570   -1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0971   -1.3284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8271   -0.5488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0169   -0.3929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2531    0.3866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0632    0.5425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3333    1.3221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.4780    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4135    2.2575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7932    1.9457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0169    1.7898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2870    1.0103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0971    0.8543    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3672    0.0748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1773   -0.0811    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8271   -2.7316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2870   -3.3552    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6372   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9073   -3.6671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7174   -3.8230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9874   -4.6025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4473   -5.2262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7174   -6.0057    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.6372   -5.0702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3672   -4.2907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 12 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 10 21  4  0  0  0  0
 21 22  2  0  0  0  0
  8 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1709

>  <JC_XSMILES>
CCN(CC)CCN(CC1=CC2=CC(OC)=CC=C2NC1=O)C(=S)NC3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.075

>  <W2 Pf proliferation inhibition EC50 uM>
3.32

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
51.41

>  <Powder data?>
Yes

>  <IFI value>
0.036697248

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1711
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 16 22  4  0  0  0  0
  2 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1711

>  <JC_XSMILES>
CC(CC(=O)NCCCCNC1=CC=NC2=CC(Cl)=CC=C12)CC(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.443

>  <W2 Pf proliferation inhibition EC50 uM>
0.2961

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.59

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1717
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 16 22  1  0  0  0  0
 19 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
 32 33  1  0  0  0  0
 11 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1717

>  <JC_XSMILES>
CC(C)OC(=O)C1=C(C)N=C(N=C1C(=O)N2CCN(C(C)C2)C(=O)NC3=C(C)C=CC=C3C)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.792

>  <W2 Pf proliferation inhibition EC50 uM>
0.642

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028037383

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-172
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-172

>  <JC_XSMILES>
CC1=CC=CC(C)=C1NC(=O)C(O)C2=CC=C(Cl)C=C2Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
2.203

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1720
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -2.8579    1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 11 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1720

>  <JC_XSMILES>
FC1=CC=C(C=C1)S(=O)(=O)N2CC3=CC=CC=C3CC2C(=O)N4CCOCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.335

>  <W2 Pf proliferation inhibition EC50 uM>
0.641

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1723
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 16 25  4  0  0  0  0
 25 26  4  0  0  0  0
 13 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1723

>  <JC_XSMILES>
CC1CCCCN1CCCNCC2=CC=C(OCC3=CC=CC=C3)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.385

>  <W2 Pf proliferation inhibition EC50 uM>
0.2977

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.65

>  <Powder data?>
Yes

>  <IFI value>
0.064814815

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1728
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -3.8062    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8538   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1893   -5.2273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7044   -5.8947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8839   -5.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5484   -5.0548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0333   -4.3874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2991   -2.7666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6860   -3.3186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0986   -3.0637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2701   -2.2567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3430   -1.7047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1276   -1.9596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2032   -2.7666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8163   -3.3186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6010   -3.0637    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7725   -2.2567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2140   -3.6157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9987   -3.3608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6118   -3.9128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4402   -4.7198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6556   -4.9747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0425   -4.4227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  6 13  4  0  0  0  0
  3 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
  4 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1728

>  <JC_XSMILES>
CC[N+]1=C(SC(C2=CC=CC=C2)=C1C3=CC=CC=C3)\C=C\N(C)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.096

>  <W2 Pf proliferation inhibition EC50 uM>
0.638

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-173
  Mrv1591402191617072D          

 32 34  0  0  1  0            999 V2000
  -12.1460   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    3.7125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 20 19  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 20 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
  8 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
  6 31  4  0  0  0  0
 31 32  4  0  0  0  0
  2 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-173

>  <JC_XSMILES>
NC1=NC(N)=C2N=C(CCC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=NC2=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02953

>  <W2 Pf proliferation inhibition EC50 uM>
0.001779

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.0081

>  <Powder data?>
Yes

>  <IFI value>
0.159722222

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1730
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  2  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  4 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1730

>  <JC_XSMILES>
CCCN1C(=O)C2=CC=CC=C2N=C1C(CC)N3CCNCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2849

>  <W2 Pf proliferation inhibition EC50 uM>
0.637

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028037383

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1732
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -0.2549    0.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8792   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2917    0.0470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1167    0.0470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5292   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3542   -0.6674    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.1167   -1.3819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2917   -1.3819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8242   -2.1195    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8242    0.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2721    1.3977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5271    2.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3341    2.3539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8861    1.7408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6312    0.9561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5890    3.1385    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.0370    3.7516    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.3960    3.3100    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
  8 16  1  0  0  0  0
  5 16  1  0  0  0  0
 16 17  2  0  0  0  0
  7 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
M  CHG  2  24   1  25  -1
M  STY  1   1 DAT
M  SAL   1  1   3
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1732

>  <JC_XSMILES>
CC1=NNC2=C1C(N(C3=CC=C(Br)C=C3)C2=O)C4=CC=C(C=C4)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>6.36

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1734
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    0.1067   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8212   -2.9491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5356   -2.5366    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.1231   -1.8221    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9481   -3.2511    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2501   -2.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2501   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9646   -0.8866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6791   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6791   -2.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9646   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -1.7116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -0.0616    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0597   -4.2590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1953   -5.0437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0203   -5.0437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2752   -4.2590    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  2 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 13 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 27 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1734

>  <JC_XSMILES>
CC(NS(=O)(=O)C1=CC=CC=C1)C(N2CCN(CC2)C3=CC=CC=C3F)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
6.35

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.060606061

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1738
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8974   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5619   -5.1657    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0468   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7112   -6.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1962   -7.2542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0166   -7.1680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3522   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8673   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2028   -4.9932    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -2.9599    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  2 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 18 28  4  0  0  0  0
 15 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1738

>  <JC_XSMILES>
CC1CC2=CC=C(F)C=C2CN1C(=O)C3=CC=C(COC4=CC=CC=C4Br)O3

>  <PF proliferation inhibition 3D7 EC50 uM>
8.37

>  <W2 Pf proliferation inhibition EC50 uM>
6.35

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1739
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -0.7930    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0320    3.9849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4445    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4445    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0320    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    1.8414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195   -1.0164    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 15 16  1  0  0  0  0
  9 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1739

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2C(N)=NC(N)=NC23CCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.393

>  <W2 Pf proliferation inhibition EC50 uM>
6.35

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1740
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    2.3276   -4.7570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3882   -4.7570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8545   -2.1123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3848   -3.0308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  2 10  1  0  0  0  0
 11  5  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 16 22  4  0  0  0  0
 14 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1740

>  <JC_XSMILES>
CC1(C)CC(CC(C)(C)N1)N=C2C=C(OC3=CC=C(Cl)C=C23)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2511

>  <W2 Pf proliferation inhibition EC50 uM>
0.609

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.6

>  <Powder data?>
Yes

>  <IFI value>
0.114285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1742
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  8 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  3 24  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1742

>  <JC_XSMILES>
COC(CNC1=CC(=NC(=N1)C2=CC=CC=N2)C3=CC=CC=N3)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.336

>  <W2 Pf proliferation inhibition EC50 uM>
0.633

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1743
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    3.2834   -0.8597    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.5689   -0.4472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8545   -0.8597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1400   -0.4472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1400    0.3778    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4255    0.7903    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2890    0.3778    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2890   -0.4472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -0.8597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -1.6847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3360   -2.1696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5909   -2.9542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4159   -2.9542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9009   -3.6217    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6709   -2.1696    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4555   -1.9147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6270   -1.1077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9626   -0.3540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3495    0.1980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6350   -0.2145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8065   -1.0214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3789   -1.4472    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4608   -2.2682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2127   -2.6077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8827   -2.1264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8008   -1.3054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0489   -0.9659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8545    0.7903    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5689    0.3778    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 10 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
 17 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
  5 28  4  0  0  0  0
 28 29  4  0  0  0  0
  2 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1743

>  <JC_XSMILES>
ClC1=CC=C(CNCCC2CCC(=O)N2CC3(CCCC3)N4CCCCC4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.632

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009708738

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1744
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
  6 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
  4 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 25 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1744

>  <JC_XSMILES>
CCCC1=NC2=CC=C(NC(=O)NCC)C=C2C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
9.05

>  <W2 Pf proliferation inhibition EC50 uM>
6.32

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.072727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1746
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  5 26  4  0  0  0  0
 26 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1746

>  <JC_XSMILES>
ClC1=CC=C2C(NCCCCNC(=O)CSC3=CC=CC=C3)=CC=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.488

>  <W2 Pf proliferation inhibition EC50 uM>
0.632

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1748
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -2.8579    1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 11 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1748

>  <JC_XSMILES>
FC1=CC=C(C=C1)S(=O)(=O)N2CC3=CC=CC=C3CC2C(=O)NC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
6.31

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011494253

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-175
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -3.5235    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6985    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2136    0.5701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4685   -0.2146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2136    1.9049    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 11 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
  9 28  4  0  0  0  0
 28 29  4  0  0  0  0
  5 29  4  0  0  0  0
 29 30  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-175

>  <JC_XSMILES>
CC1=C(C)C2=C(S1)N=C(CN(C3CCCCC3)C(=O)CCC4=CC=CC=C4)NC2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.424

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.939

>  <Powder data?>
No

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1750
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743    3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8163   -2.3784    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0416   -2.3784    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 14 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  1  0  0  0  0
 11 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1750

>  <JC_XSMILES>
COC1=CC(OC)=CC(=C1)N2C(=O)N(CC3=CC=C(C=C3)C(C)(C)C)C4=CC=CC=C4S2(=O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
3.75

>  <W2 Pf proliferation inhibition EC50 uM>
6.3

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1755
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 12 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1755

>  <JC_XSMILES>
OCCN1CCN(CC1)C2=CC(=NC(=N2)C3=CC=NC=C3)C4=CC=CN=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.945

>  <W2 Pf proliferation inhibition EC50 uM>
0.626

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1758
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 O   0  3  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 14 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 10 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 33 36  1  0  0  0  0
 36 37  1  0  0  0  0
 36 38  1  0  0  0  0
M  CHG  1  17   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1758

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)C(=CC2=CC(=CC(=[O+]2)C3=CC=CC=C3)C4=CC=CC=C4)C5=CC=C(C=C5)N(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.988

>  <W2 Pf proliferation inhibition EC50 uM>
0.898

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.38

>  <Powder data?>
Yes

>  <IFI value>
0.127272727

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1759
  Mrv1591402191617072D          

 16 18  0  0  0  0            999 V2000
    1.1270    2.5559    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    2.5559    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  1  0  0  0  0
 11 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1759

>  <JC_XSMILES>
O=C1C(=O)C2=NC=CC=C2C3=CC=CN=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.644

>  <W2 Pf proliferation inhibition EC50 uM>
0.369

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.91

>  <Powder data?>
Yes

>  <IFI value>
0.221428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1760
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  8 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1760

>  <JC_XSMILES>
COCCNC1=CC(=NC(=N1)C2=CC=CC=N2)C3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.44

>  <W2 Pf proliferation inhibition EC50 uM>
0.624

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1761
  Mrv1591402191617072D          

 23 22  0  0  0  0            999 V2000
    5.5539    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1414   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3164   -0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9039    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3164    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9039   -1.4289    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
    3.4914   -2.1434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9039   -2.8579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664   -2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -2.8579    0.0000 Si  0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.5724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684   -3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895   -1.0164    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7605   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895   -0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750    0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -1.8414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474   -1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -3.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
  6 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
  6 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
M  CHG  1   6   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1761

>  <JC_XSMILES>
CCN(CC)[P+](N(C)C[Si](C)(C)C)(N(CC)CC)N(CC)CC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1545

>  <W2 Pf proliferation inhibition EC50 uM>
0.523

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.41

>  <Powder data?>
Yes

>  <IFI value>
0.090909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1762
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  2  0  0  0  0
  8 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1762

>  <JC_XSMILES>
CCN(CC)CCN(CC1=CC2=CC=C(C)C=C2NC1=O)C(=S)NC(C)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.694

>  <W2 Pf proliferation inhibition EC50 uM>
1.335

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.47

>  <Powder data?>
Yes

>  <IFI value>
0.08411215

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1764
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1764

>  <JC_XSMILES>
CC1=CC=C(C=N1)C(=O)NCCN2CCCCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.31

>  <W2 Pf proliferation inhibition EC50 uM>
0.621

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.006896552

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1769
  Mrv1591402191617072D          

 41 46  0  0  0  0            999 V2000
    0.8034    3.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6280    3.3567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0626    2.6554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8872    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3218    1.9800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9318    1.2530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1072    1.2272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6726    1.9284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3664    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1910    0.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5810    1.3045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1464    2.0057    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4056    1.3302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7956    2.0573    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3610    2.7585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6340    3.1485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3352    3.5831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6202    2.0830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0548    1.3818    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0102    2.8100    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8348    2.8358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2248    3.5628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0494    3.5885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4840    2.8873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0940    2.1603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2694    2.1345    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3086    2.9131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1332    2.9388    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.3343    2.0885    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.2828    3.7377    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.6256   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4502   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8849   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4949   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6703   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2357   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4111   -0.8765    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8784   -1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1147   -1.1947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1752   -0.3719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9765   -0.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
 10 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
  9 41  1  0  0  0  0
 37 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1769

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2N(C(=O)CN(C3CC3)C(=O)NC4=CC=C(C=C4)C(F)(F)F)C5=CC=CC=C5N6C=CC=C26

>  <PF proliferation inhibition 3D7 EC50 uM>
7.51

>  <W2 Pf proliferation inhibition EC50 uM>
6.2

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.042016807

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1773
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 11 10  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1773

>  <JC_XSMILES>
FC1=CC=C(C=C1)C(=O)NN=C\C(Br)=C\C2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.981

>  <W2 Pf proliferation inhibition EC50 uM>
0.618

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1775
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -4.2868   -4.1250    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1775

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(=C1)C(=O)NCCC(C2=CC=CC=C2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3022

>  <W2 Pf proliferation inhibition EC50 uM>
0.618

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1776
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -3.8837    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    2.8744    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 12 20  1  0  0  0  0
 20 21  2  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
  3 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1776

>  <JC_XSMILES>
COC1=CC=C(CN(C=O)\C=C2/SC3=CC=CC=C3C2=O)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.617

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1778
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  6 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 17 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1778

>  <JC_XSMILES>
NC1=NC(N)=C(N=C1Cl)C(=O)NC(=N)NCC2=CC=C(Cl)C(Cl)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0896

>  <W2 Pf proliferation inhibition EC50 uM>
0.2832

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.59

>  <Powder data?>
Yes

>  <IFI value>
0.028169014

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1779
  Mrv1591402191617072D          

 41 44  0  0  0  0            999 V2000
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 17 28  4  0  0  0  0
 23 28  4  0  0  0  0
 10 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 36 39  4  0  0  0  0
 30 39  4  0  0  0  0
  6 40  4  0  0  0  0
 40 41  4  0  0  0  0
  3 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1779

>  <JC_XSMILES>
COC1=CC=C(CC(=O)N(CCCC(C)NC2=CC(OC)=CC3=CC=CN=C23)CC4=CC=C(OC)C(OC)=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.198

>  <W2 Pf proliferation inhibition EC50 uM>
0.666

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.8

>  <Powder data?>
No

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-178
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
  5 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  2 15  1  0  0  0  0
 10 15  4  0  0  0  0
  4 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 16 25  4  0  0  0  0
M  CHG  2   7   1   8  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-178

>  <JC_XSMILES>
CN1C=C(C(C[N+]([O-])=O)C2=CC=CC=C12)C3=CC=C4C=CC=CC4=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.791

>  <W2 Pf proliferation inhibition EC50 uM>
2.114

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.166666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1781
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  7 18  1  0  0  0  0
 13 18  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 22 23  4  0  0  0  0
  3 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1781

>  <JC_XSMILES>
COC1=CC(NC2=CC(=O)C(=O)C3=CC=CC=C23)=C(OC)C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2935

>  <W2 Pf proliferation inhibition EC50 uM>
0.687

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.15

>  <Powder data?>
Yes

>  <IFI value>
0.135135135

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1783
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -2.5855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 13 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
  8 28  4  0  0  0  0
 28 29  4  0  0  0  0
  5 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1783

>  <JC_XSMILES>
CC(C)(C)C1=CC=C(CNC(=O)C(CC2=CC=C(O)C=C2)C3=CC=CC=C3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>8.68

>  <W2 Pf proliferation inhibition EC50 uM>
3.27

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
53.17

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1784
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
    5.0013   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  3  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 13 22  4  0  0  0  0
  5 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
  3 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1784

>  <JC_XSMILES>
N#CC1=CC(OC2=CC=C(C=C2)C3=CN=C4C=CC=CC4=N3)=NC5=CC=CC=C15

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
6.15

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1796
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 16 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1796

>  <JC_XSMILES>
CN(C)C(=O)NCCCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.992

>  <W2 Pf proliferation inhibition EC50 uM>
0.609

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009174312

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1799
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -7.4106   -1.2605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9257   -0.5931    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1052   -0.6793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6203   -0.0119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7998   -0.0981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4642   -0.8518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9492   -1.5193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7697   -1.4330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6438   -0.9380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0917   -0.3250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3381   -0.6605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4243   -1.4810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2313   -1.6525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8112   -2.0330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0266   -1.7781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4135   -2.3301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5850   -3.1371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3696   -3.3920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9827   -2.8400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7673   -3.0949    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6236   -0.2480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6236    0.5770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1946   -0.2480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5198   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2343   -0.2480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5198   -1.4855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1799

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=NN(C(C2)C3=CC=CC=C3F)C(=O)CCC(O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.606

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1801
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
 12 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1801

>  <JC_XSMILES>
CC1CCN(CC1)C2=NN=CC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>6.05

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1802
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    2.6425   -2.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8974   -2.0383    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3454   -1.4252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5384   -1.5967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9864   -0.9836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2413   -0.1990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8288    0.5155    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3809    1.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1345    0.7930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490    1.2055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5635    0.7930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2780    1.2055    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9924    0.7930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9924   -0.0320    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7069    1.2055    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4214    0.7930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1358    1.2055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8503    0.7930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8503   -0.0320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1358   -0.4445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4214   -0.0320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0483   -0.0275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6003   -0.6406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  9 22  4  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
  3 23  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   7
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1802

>  <JC_XSMILES>
COC1=CC=C2NC=C(CCNC(=O)OC3=CC=CC=C3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.292

>  <W2 Pf proliferation inhibition EC50 uM>
0.604

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1805
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3260   -1.7269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8781   -2.3400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4656   -3.0545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6586   -2.8830    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 10  1  0  0  0  0
  2 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1805

>  <JC_XSMILES>
O=C(NCSC1=NCCS1)C2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>6.03

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1809
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -2.8106    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -2.1975    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -1.4830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -1.6545    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2288   -0.7293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0492   -0.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3848    0.1106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8999    0.7780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2354    1.5317    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0794    0.6918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7438   -0.0619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
  2 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1809

>  <JC_XSMILES>
CC(SC1=NN=C(O1)C2=CC=C(O)C=C2)C(=O)NC3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.601

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.061403509

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1811
  Mrv1591402191617072D          

 12 12  0  0  0  0            999 V2000
   -0.7145    3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
  6 12  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1811

>  <JC_XSMILES>
ClCC(=O)NC1=CC=C(Cl)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.544

>  <W2 Pf proliferation inhibition EC50 uM>
0.342

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.7

>  <Powder data?>
Yes

>  <IFI value>
0.03539823

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1816
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
  3 12  4  0  0  0  0
  8 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 15 16  1  4  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1816

>  <JC_XSMILES>
COC1=CC=C2C=C(C=CC2=C1)C(C)=NO

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>5.97

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.016129032

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1818
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -12.3750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 21 27  4  0  0  0  0
 27 28  1  0  0  0  0
  7 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1818

>  <JC_XSMILES>
CCCCCCN(C(C)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC(Cl)=C3C)C(=O)COCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.165

>  <W2 Pf proliferation inhibition EC50 uM>
0.596

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1821
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.2934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9947   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 14 18  4  0  0  0  0
 12 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
 22 29  4  0  0  0  0
 29 30  4  0  0  0  0
 19 30  4  0  0  0  0
  8 31  4  0  0  0  0
  4 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1821

>  <JC_XSMILES>
CN(C)C1=CC=CC(NC2=CC(=NC3=CC=NN23)C4=CC=C(CC(N)C(O)=O)C=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.6

>  <W2 Pf proliferation inhibition EC50 uM>
0.594

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.010989011

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1822
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
   -2.0492   -0.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2288   -0.7293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -1.4830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -2.1975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -2.8106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9252   -3.6175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7098   -3.8725    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3121   -4.1696    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4725   -3.9146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -1.6545    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 10 23  4  0  0  0  0
  3 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1822

>  <JC_XSMILES>
CCC1=CC(C(=O)OC)=C(NC(=S)NC(C)C2=CC=NC=C2)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.55

>  <W2 Pf proliferation inhibition EC50 uM>
5.16

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>86.94

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1824
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -6.3587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 19 27  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  27
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1824

>  <JC_XSMILES>
CC(C)N1CCCC(C1)C(=O)NC2=CC=C(C=C2)C3=NC4=CC=CC=C4N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.969

>  <W2 Pf proliferation inhibition EC50 uM>
0.593

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1825
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1825

>  <JC_XSMILES>
COC1=CC(OC)=CC(=C1)C(=O)N2CCN(CC2)CC3=CC=CC(Br)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
5.92

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1826
  Mrv1591402191617072D          

 18 21  0  0  0  0            999 V2000
    2.2864   -3.8025    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.7639   -3.1297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4200   -2.3798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8976   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7190   -1.7842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3259   -1.2255    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0449   -1.6301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8267   -1.3665    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4458   -1.9117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2276   -1.6482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8467   -2.1934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6841   -3.0022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9023   -3.2658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2832   -2.7205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5014   -2.9841    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8823   -2.4389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0628   -2.5342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5853   -3.2069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
  5 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1826

>  <JC_XSMILES>
BrC1=CC=C2NC3=NC4=CC=CC=C4N=C3C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>5.92

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.037735849

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1828
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    0.1070    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6075    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0200    1.8904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1950    0.4614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3220    0.7634    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3220   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6076   -0.4741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0365   -0.4740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0365   -1.2990    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8435   -1.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0985   -2.2551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5465   -2.8683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8015   -3.6529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6085   -3.8244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1605   -3.2112    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9055   -2.4266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4575   -1.8135    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.3221   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6076   -1.2991    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3221   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9896   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7347   -3.8061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9097   -3.8061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6547   -3.0215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4248   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3957   -4.3874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8806   -5.0549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5450   -5.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2755   -5.8947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7604   -5.2273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7510   -0.0615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4655   -0.4740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1799   -0.0614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1799    0.7636    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4654    1.1760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7509    0.7635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  9 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
  8 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  24
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1828

>  <JC_XSMILES>
CC(C)(C)NC(=O)C(N(CC1=CC=CC=C1Cl)C(=O)C2=CC=C(N2)C3=CC=CC=C3)C4=CC=NC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>6.47

>  <W2 Pf proliferation inhibition EC50 uM>
>3.99

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
67.45

>  <Powder data?>
Yes

>  <IFI value>
0.054054054

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-183
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
    6.9246    4.8229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6543    3.0624    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4793    1.6335    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    4.3808    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -5.1212    4.3808    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.8837    5.0953    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 16 22  4  0  0  0  0
 22 23  4  0  0  0  0
 13 23  4  0  0  0  0
 19 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 32 35  1  0  0  0  0
 35 36  1  0  0  0  0
 35 37  2  0  0  0  0
 27 38  4  0  0  0  0
 38 39  4  0  0  0  0
 24 39  4  0  0  0  0
M  CHG  2  35   1  36  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-183

>  <JC_XSMILES>
OC(=O)C1=CC=C(C=C1)S(=O)(=O)C2=CC=C3C(=O)N(C(=O)C3=C2)C4=CC=C(SC5=CC=C(C=C5)[N+]([O-])=O)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
2.069

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1830
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -1.2546   -5.9861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0957   -5.5184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -4.8948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459   -5.0507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -4.4270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961   -4.5829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261   -5.9861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -3.9593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -3.1798    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -2.5561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -1.7766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763   -1.1529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6864   -1.3088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9565   -2.0884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164   -2.7120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6864   -3.4916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4966   -3.6475    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463   -4.1152    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164   -4.8948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763   -5.5184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463   -6.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9565   -6.4539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4966   -5.8302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2265   -5.0507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7666   -4.4270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5767   -4.5829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -3.6475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -3.0238    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9058   -3.4916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3657   -4.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444   -3.9593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.1798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -2.5561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -2.7120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444   -1.7766    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.2546   -1.6207    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0957   -1.1529    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
  6 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 35 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  2  0  0  0  0
M  CHG  2  37   1  38  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1830

>  <JC_XSMILES>
CCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3OC)C(=O)C4=CC=CC(=C4)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.591

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1831
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -4.6480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -6.0770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.0125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -4.2868   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  2  0  0  0  0
M  CHG  2  28   1  29  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1831

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)S(=O)(=O)C3=CC=C(Cl)C(=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2431

>  <W2 Pf proliferation inhibition EC50 uM>
0.1853

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.137

>  <Powder data?>
No

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-184
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 10 17  4  0  0  0  0
 17 18  1  0  0  0  0
 13 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
  3 23  4  0  0  0  0
M  CHG  2  19   1  20  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-184

>  <JC_XSMILES>
COC1=CC=C(NC(=O)C2=C(C)C(=C(Cl)N=C2Cl)[N+]([O-])=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
2.057

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1841
  Mrv1591402191617072D          

 18 20  0  0  1  0            999 V2000
    2.0846   -2.3391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7568   -1.5821    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.9372   -1.4874    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.4455   -2.1499    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6094   -0.7304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1011   -0.0679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9207   -0.1626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4124    0.4999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2320    0.4052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7237    1.0677    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5598   -0.3518    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.8876   -1.1089    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0681   -1.0143    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.2485   -0.9196    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.5763   -1.6767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3169   -0.0240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9793   -0.5157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4115    0.7955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  2  3  1  0  0  0  0
  3  4  1  6  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 11  9  1  0  0  0  0
 11 12  1  0  0  0  0
 13 12  1  6  0  0  0
 13 11  1  0  0  0  0
 14 13  1  0  0  0  0
  2 14  1  0  0  0  0
 14  7  1  0  0  0  0
 14 15  1  1  0  0  0
 11 16  1  1  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1841

>  <JC_XSMILES>
C[C@H]1[C@H](O)CCC2=CC(=O)[C@@]3(O[C@@H]3[C@]12C)C(C)=C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.787

>  <W2 Pf proliferation inhibition EC50 uM>
0.586

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.051724138

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1842
  Mrv1591402191617072D          

 37 39  0  0  0  0            999 V2000
   -0.7955   -0.3066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0108   -0.5616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1607   -1.3685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9453   -1.6235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1168   -2.4304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5037   -2.9825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2809   -2.7275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4524   -1.9206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6753   -3.7894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1232   -4.4025    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5357   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3427   -4.9455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2002   -5.8707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1354   -6.6244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9539   -6.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5535   -5.5351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 18 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
 11 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 34 37  1  0  0  0  0
M  CHG  2  31   1  32  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1842

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2N=C(C=C2NC(=O)CN(C(C)C)C(=O)C3=CC=C(C)C(=C3)[N+]([O-])=O)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.548

>  <W2 Pf proliferation inhibition EC50 uM>
1.819

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
31.09

>  <Powder data?>
Yes

>  <IFI value>
0.008196721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1848
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    3.4698   -5.8106    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8039   -5.3235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0492   -5.6567    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8928   -4.5033    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2269   -4.0163    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3157   -3.1961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7044   -2.6421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8836   -2.7258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4008   -2.0568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7387   -1.3042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5595   -1.2205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0423   -1.8895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8625   -1.9783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4773   -1.4283    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2612   -1.6857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9769   -1.2754    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5883   -1.8294    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2503   -2.5820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4301   -2.4932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8153   -3.0433    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0315   -2.7859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  5  4  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  6 21  1  0  0  0  0
 13 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1848

>  <JC_XSMILES>
NC(=S)NN=C1C2=CC=CC=C2C3=NC4=NON=C4N=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
1.129

>  <W2 Pf proliferation inhibition EC50 uM>
0.582

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1849
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    1.5662   -2.8960    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -2.4835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -2.8960    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -3.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.1336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.9586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0904   -5.4435    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1645   -6.2281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9895   -6.2281    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2445   -5.4435    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3205   -6.8955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1409   -6.8092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6259   -7.4766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2904   -8.2303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699   -8.3166    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0151   -7.6492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -1.6585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -1.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5873   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -0.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  2 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
 20 21  1  0  0  0  0
 19 24  1  0  0  0  0
 17 25  1  0  0  0  0
 23 24  1  0  0  0  0
 21 26  1  0  0  0  0
 23 25  1  0  0  0  0
 22 23  1  0  0  0  0
 17 26  1  0  0  0  0
 19 20  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  10
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1849

>  <JC_XSMILES>
O=C(NCCC1=NC(=NN1)C2=CC=CN=C2)C34CC5CC(CC(C5)C3)C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.581

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-185
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 25 26  1  0  0  0  0
 17 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 15 29  4  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 30 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-185

>  <JC_XSMILES>
CC(=O)NC1=CC=C(C=C1)C(C)=NNC2=NC(NC3=CC(C)=CC=C3C)=NC(=N2)N4CCOCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
2.055

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1851
  Mrv1591402191617072D          

 28 29  0  0  0  0            999 V2000
   -3.3980   -1.8514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0477   -2.3191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5077   -2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6975   -2.7868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1574   -3.4105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6527   -3.2546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1928   -3.8782    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0029   -3.7223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2730   -2.9427    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5430   -4.3459    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3531   -4.1900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8932   -4.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7034   -4.6577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2435   -5.2814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9734   -6.0609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1633   -6.2168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6232   -5.5932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9227   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7023   -2.7450    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1432   -2.2050    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1928   -1.6954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6527   -1.0718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9227   -0.2923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -0.1363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0029    0.6432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2730   -0.7600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0029   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  7 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1851

>  <JC_XSMILES>
CCCCCCC(NC(=O)OCC1=CC=CC=C1)S(=O)(=O)C2=CC=C(C)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
5.8

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.025974026

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1854
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  1 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1854

>  <JC_XSMILES>
C(COC1=CC=CC=C1C2=CC=CC=C2)NCCN3CCOCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
10.09

>  <W2 Pf proliferation inhibition EC50 uM>
2.7

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
46.78

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1856
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -4.7668   -1.0303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0994   -0.5453    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3457   -0.8809    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2594   -1.7014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5058   -2.0369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6782   -0.3960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6782    0.4290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8936    0.6840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8936   -0.6509    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9962   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
 11  9  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  3  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  23
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1856

>  <JC_XSMILES>
CCN(CC)C1=CC=C(O1)C=C(C#N)C2=NC3=CC=CC=C3N2

>  <PF proliferation inhibition 3D7 EC50 uM>
3.35

>  <W2 Pf proliferation inhibition EC50 uM>
>2.668

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
46.24

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1863
  Mrv1591402191617072D          

 23 26  0  0  1  0            999 V2000
    2.2396   -1.0709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -1.4834    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.6685   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -0.2459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5205   -0.3834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5205   -0.9334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830   -1.4834    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975   -0.2459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8119    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5264   -0.2459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -2.7209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -3.9584    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -3.9584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -2.7209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -2.3084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -2.7209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
  2 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 13 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1863

>  <JC_XSMILES>
O[C@@H](C1CC2CCN1CC2C=C)C3=CC=NC4=CC=C(O)C=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.404

>  <W2 Pf proliferation inhibition EC50 uM>
5.72

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1871
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  2  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  5 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 14 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  2  0  0  0  0
  8 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1871

>  <JC_XSMILES>
CCCCN1C(=N)C(=CC2=C1N=C3N(C=CC=C3C)C2=O)C(=O)NC(C)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.384

>  <W2 Pf proliferation inhibition EC50 uM>
>5.68

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1872
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    0.0487    1.3641    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5033    0.7510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3103    0.9225    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5652    1.7071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3722    1.8787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6271    2.6633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0751    3.2764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2681    3.1048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0132    2.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2483   -0.0336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7333   -0.7011    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2483   -1.3685    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5363   -1.1136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5363   -0.2886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1813    0.2258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9856    0.0422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3436   -0.7011    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9856   -1.4444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1813   -1.6280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 13 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1872

>  <JC_XSMILES>
O=C(NC1CCCCC1)C2=NOC3=C2CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
5.67

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.114285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1873
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 13 20  4  0  0  0  0
  8 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  2  0  0  0  0
 27 29  4  0  0  0  0
  7 29  4  0  0  0  0
 29 30  4  0  0  0  0
  4 30  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1873

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C2N(CC(=O)NC3=CC=C(F)C(Cl)=C3)C4=CC=CC=C4C(=O)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
5.67

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024096386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1875
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -4.5376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.2999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.2999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -4.5374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808   -4.6237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
  8 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 19 25  4  0  0  0  0
  4 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 35 37  1  0  0  0  0
 30 38  1  0  0  0  0
 38 39  1  0  0  0  0
 38 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1875

>  <JC_XSMILES>
CCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC(C)=C3)C(=O)NC4=C(C=CC=C4C(C)C)C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
3.17

>  <W2 Pf proliferation inhibition EC50 uM>
4.58

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
80.89

>  <Powder data?>
Yes

>  <IFI value>
0.009433962

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1877
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    3.5724    1.2375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 18 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1877

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)C(=O)NCCCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.486

>  <W2 Pf proliferation inhibition EC50 uM>
0.565

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1880
  Mrv1591402191617072D          

 43 46  0  0  0  0            999 V2000
    6.3685   -7.3278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6385   -6.5482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0984   -5.9246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3685   -5.1450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8284   -4.5214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0984   -3.7418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5583   -3.1182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8284   -2.3387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6385   -2.1827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1786   -2.8064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9086   -3.5859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9086   -1.4032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7187   -1.2473    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3685   -0.7796    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5583   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0182   -0.3118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2081   -0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6680    0.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9381    0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3178    0.6236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5077    0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9676    1.0914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1574    0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1126    0.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2376    1.8709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0477    2.0268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3178    2.8064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1279    2.9623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6680    2.3387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3980    1.5591    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5878    1.4032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6385    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4486    0.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7187    0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5288    1.0914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0689    0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8790    0.6236    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4191    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7989   -0.3118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3390   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.1491   -0.7796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9887   -0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 21 32  4  0  0  0  0
 27 32  4  0  0  0  0
 14 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 37 40  4  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 40 43  4  0  0  0  0
 34 43  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1880

>  <JC_XSMILES>
CCCCCC1=CC=C(C=C1)C(=O)N(CCCC(C)NC2=CC(OC)=CC3=CC=CN=C23)CC4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.514

>  <W2 Pf proliferation inhibition EC50 uM>
0.2838

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.03

>  <Powder data?>
No

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1881
  Mrv1591402191617072D          

 31 35  0  0  1  0            999 V2000
    0.8106   -3.8791    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -3.0541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -2.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -1.8166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -1.8166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -2.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -0.5791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    0.6584    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2396    1.0709    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.2396    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    2.3084    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.0915    1.7584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0915    1.2084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    0.6584    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.8959    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.3830    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    0.6584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.8959    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 11 10  1  6  0  0  0
 12 11  1  6  0  0  0
 12 13  1  0  0  0  0
 14 13  1  1  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 19 18  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  1  0  0  0
 20 21  2  0  0  0  0
 11 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 22 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1881

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C(=O)O[C@@H]([C@@H]2C[C@@H]3CCN2C[C@@H]3C=C)C4=CC=NC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.412

>  <W2 Pf proliferation inhibition EC50 uM>
0.564

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.010416667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1886
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 19 23  4  0  0  0  0
 15 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 17 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1886

>  <JC_XSMILES>
CCCC(=O)N1CCN(CC1C)C(=O)C2=NC(=NC(C(C)C)=C2C(=O)OC)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.88

>  <W2 Pf proliferation inhibition EC50 uM>
0.475

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.44

>  <Powder data?>
No

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1887
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9049   -5.0224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599   -5.8070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849   -5.8070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2398   -5.0224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4698   -6.4745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2903   -6.3882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7752   -7.0557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4396   -7.8094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6191   -7.8956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1342   -7.2282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
  9 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
  8 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 35 37  4  0  0  0  0
 37 38  4  0  0  0  0
 32 38  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  25
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1887

>  <JC_XSMILES>
CC(C)(C)NC(=O)C(N(CCCN1CCOCC1)C(=O)C2=CC=C(N2)C3=CC=CC=C3)C4=CC=C(F)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.013

>  <W2 Pf proliferation inhibition EC50 uM>
0.562

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.031578947

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1888
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    1.7605   -3.9336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0461   -3.5211    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0461   -2.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3316   -2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3316   -1.4586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0461   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7605   -1.4586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7605   -2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0461   -0.2211    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7605    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750   -1.0461    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    0.1914    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9039   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7618   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7618   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -1.4586    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474   -1.4586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3316    0.1914    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3829    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0809   -0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7441    0.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3316    1.6204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7441    2.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5691    2.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9816    1.6204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5691    0.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
  9 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1888

>  <JC_XSMILES>
COC1=CC=C(C=C1)N(CC(=O)NCCC2=CC=C(F)C=C2)S(=O)(=O)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
5.62

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-189
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1904   -1.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5253   -1.1651    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 17 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-189

>  <JC_XSMILES>
CC(C)NC(=O)N1CCN(CC1)C(=O)COC(C2=CC=CS2)C3=CC=CN=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
2.022

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019417476

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1892
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.0940    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -0.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.0494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.0494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.7639    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -3.4784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -0.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
  4 13  4  0  0  0  0
 10 14  2  0  0  0  0
 14 15  1  4  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
 24 25  4  0  0  0  0
 18 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1892

>  <JC_XSMILES>
CCOC1=CC=C2N(C)C(SC2=C1)=NC(=O)NC3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>8.3

>  <W2 Pf proliferation inhibition EC50 uM>
0.997

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.83

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1897
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    6.3545   -6.7195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0690   -6.3070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0690   -5.4820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7834   -6.7195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4979   -6.3070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2124   -6.7195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.9269   -6.3070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9269   -5.4820    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.6413   -6.7195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3558   -6.3070    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.0703   -6.7195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7847   -6.3070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4992   -6.7195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4992   -7.5445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7847   -7.9570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0703   -7.5445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3558   -7.9570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3558   -8.7820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.0703   -9.1945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6413   -9.1945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2137   -7.9570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.9674   -7.6214    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.5194   -8.2345    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.3444   -8.2345    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.7569   -8.9490    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.3444   -9.6635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.5194   -9.6635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.1069   -8.9490    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2999   -8.7775    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 14 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
 21 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1897

>  <JC_XSMILES>
CN(C)CCNC(=O)COC1=CC=C(C=C1CN(C)C)C2=NC3=CC=CC=C3S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.622

>  <W2 Pf proliferation inhibition EC50 uM>
0.557

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.034188034

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-190
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
   -1.4534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1970    0.8415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6095    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -3.9979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 12  1  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 13 28  4  0  0  0  0
  5 28  4  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-190

>  <JC_XSMILES>
CC1=C(C)C2=C(S1)N=C(C3CC3)N(C4CCN(CC4)C(=O)C5=CC=CC=N5)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
2.015

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1900
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0828   -2.0140    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7502   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4953   -0.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3297   -0.7445    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5349   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7064   -2.5910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4910   -2.8459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1041   -2.2939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8887   -2.5488    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.9326   -1.4869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1479   -1.2320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4888   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6603   -0.7221    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1019   -2.0811    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8865   -1.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4996   -2.3782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3281   -3.1852    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5434   -3.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3719   -4.2471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9303   -2.8881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9411   -3.7372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7258   -3.4823    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7696   -4.5442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3827   -5.0962    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  3  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
  4 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 22 28  1  0  0  0  0
 25 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1900

>  <JC_XSMILES>
CCC1=C(C=NN1C2=NC(=CS2)C3=CC=C(Br)C=C3)C(=O)N4CCN(C(C)C4)C(=O)CCl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.656

>  <W2 Pf proliferation inhibition EC50 uM>
0.481

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.66

>  <Powder data?>
No

>  <IFI value>
0.047619048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1902
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
  9 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
  6 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
 20 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  1  0  0  0  0
 32 35  1  0  0  0  0
 19 35  1  0  0  0  0
M  CHG  2  16   1  17  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1902

>  <JC_XSMILES>
CCOC(=O)C1=C(N)N(C2=CC=CC(=C2)[N+]([O-])=O)C3=C(C1C4=CC=C(Cl)C=C4)C(=O)CC(C)(C)C3

>  <PF proliferation inhibition 3D7 EC50 uM>
6.14

>  <W2 Pf proliferation inhibition EC50 uM>
5.55

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1905
  Mrv1591402191617072D          

 72 78  0  0  1  0            999 V2000
   -0.6351   -1.0185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1017   -1.3896    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7915   -0.9371    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.4371   -0.1921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2969    0.6209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3812    1.4416    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6838    2.2091    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0989    2.4698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9018    3.0048    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7259    3.0433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0172    2.2714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3732    1.7559    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4117    0.9318    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8313    2.1378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1226    1.3659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5998    0.7277    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8911   -0.0441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9367    1.2323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2280    0.4604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0421    0.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3334   -0.4451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8107   -1.0833    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9966   -0.9496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7052   -0.1778    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0347   -1.9505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9161   -1.9888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3592   -1.2929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9109   -0.6565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1834   -1.3288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5645   -2.0605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3887   -2.0963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1214   -2.7564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2971   -2.7205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8540   -3.4164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4595    1.8705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2836    1.9090    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5016    2.7047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8123    3.1579    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1682    2.6423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3541    2.7760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0628    3.5479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5856    4.1861    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2943    4.9579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4802    5.0916    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8171    5.5961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4553    5.0733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1789    6.1189    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3399    6.2343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2487    3.6815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9574    4.4534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0602    2.0258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7850    2.4198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3098    1.2394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3380    0.4149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1427   -0.3866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7384   -1.1058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3958   -1.6042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1551   -1.6892    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.6536   -2.3465    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4360   -2.0936    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.7387   -2.8610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6345   -2.2889    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.7189   -3.1096    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8100   -2.2608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6698   -3.0738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0236   -2.0113    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6693   -2.7564    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8469   -2.8221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3788   -2.1427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4927   -3.5671    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3337   -1.5589    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.7916   -2.1807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  1  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  4  0  0  0
  7  6  1  0  0  0  0
  7  8  1  6  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 12 11  1  0  0  0  0
  7 12  1  0  0  0  0
 12 13  1  1  0  0  0
 11 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 26 33  4  0  0  0  0
 33 34  1  0  0  0  0
 18 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 35 39  4  0  0  0  0
 39 40  4  0  0  0  0
 14 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  1  0  0  0  0
 42 43  1  0  0  0  0
 43 44  2  0  0  0  0
 43 45  1  0  0  0  0
 45 46  1  0  0  0  0
 45 47  1  0  0  0  0
 45 48  1  0  0  0  0
 41 49  4  0  0  0  0
 10 49  4  0  0  0  0
 49 50  1  0  0  0  0
 37 51  1  0  0  0  0
 51 52  1  0  0  0  0
 51 53  2  0  0  0  0
 53 54  1  4  0  0  0
 54 55  2  0  0  0  0
 55 56  1  4  0  0  0
 56 57  1  0  0  0  0
 58 56  1  0  0  0  0
 58 59  1  6  0  0  0
 58 60  1  0  0  0  0
 60 61  1  1  0  0  0
 60 62  1  0  0  0  0
 62 63  1  1  0  0  0
 62 64  1  0  0  0  0
 64 65  1  0  0  0  0
 66 64  1  0  0  0  0
 66 67  1  6  0  0  0
 67 68  1  0  0  0  0
 68 69  1  0  0  0  0
 68 70  2  0  0  0  0
 66 71  1  0  0  0  0
 71  3  1  0  0  0  0
 71 72  1  6  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1905

>  <JC_XSMILES>
CO[C@H]1C=CO[C@@]2(C)OC3=C([C@H]2O)C4=C(OC)C(N5CCN(CC5)CC6=C(C)C=C(C)C=C6C)=C7N=C(OC7=C4C(OC(=O)C(C)(C)C)=C3C)C(C)=CC=CC(C)[C@H](O)[C@@H](C)[C@@H](O)C(C)[C@H](OC(C)=O)[C@@H]1C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2212

>  <W2 Pf proliferation inhibition EC50 uM>
0.554

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.021276596

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1906
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5013   -3.1356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3227   -2.3301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2413   -3.5633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5806   -3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0537   -4.1673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7050   -4.9149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1168   -4.9868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5900   -4.3110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
  4 13  4  0  0  0  0
 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
  2 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1906

>  <JC_XSMILES>
O=C(NC1=CC=C2CCN(CC2=C1)C3CCSCC3)C4(CC4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>5.53

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1907
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 17 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1907

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(=O)N(C)CCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.797

>  <W2 Pf proliferation inhibition EC50 uM>
0.553

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1909
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
  7 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 36 38  1  0  0  0  0
 38 39  1  0  0  0  0
 38 40  2  0  0  0  0
M  CHG  2  38   1  39  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1909

>  <JC_XSMILES>
CCCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3OC)C(=O)C4=CC=CC(=C4)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.983

>  <W2 Pf proliferation inhibition EC50 uM>
0.355

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.45

>  <Powder data?>
No

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1911
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  2  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 11 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
  9 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1911

>  <JC_XSMILES>
O=C(C1CCCCN1)N2CC(C3=CC=CC=C3)C4=CC=CC=C4C2CN5CCCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.439

>  <W2 Pf proliferation inhibition EC50 uM>
0.2574

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.68

>  <Powder data?>
No

>  <IFI value>
0.085714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1912
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769   -1.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8839   -1.4811    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8220   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3740   -3.0504    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1191   -3.8350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6711   -4.4481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4162   -5.2327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6092   -5.4042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0572   -4.7911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3121   -4.0065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7601   -3.3934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  2  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  2  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  2  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 11 19  4  0  0  0  0
  8 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   5
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1912

>  <JC_XSMILES>
CN1C(=O)NC(=O)C2=C1N=C(NC3CCCCC3)N2CC(O)COC4=CC=CC=C4C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.701

>  <W2 Pf proliferation inhibition EC50 uM>
0.549

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1915
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -2.2925    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4827   -1.5079    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9925   -3.0771    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5222   -2.0375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -2.5896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9199   -2.3346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -1.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8761   -1.2727    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.4784   -0.9756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -1.2306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1915

>  <JC_XSMILES>
NNC(=O)C1CCCN1S(=O)(=O)C2=CC=C(Cl)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.564

>  <W2 Pf proliferation inhibition EC50 uM>
0.547

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.010526316

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1918
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 11 18  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
  2 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1918

>  <JC_XSMILES>
CC1=CC=C(CNC(=N)NC2=NC(C)=CC(C)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.653

>  <W2 Pf proliferation inhibition EC50 uM>
0.609

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.18

>  <Powder data?>
Yes

>  <IFI value>
0.075268817

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1921
  Mrv1591402191617072D          

 13 13  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1921

>  <JC_XSMILES>
COC(=O)CS(=O)C1=CC=CC=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.647

>  <W2 Pf proliferation inhibition EC50 uM>
0.543

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.021052632

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1922
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  4 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1922

>  <JC_XSMILES>
CC1=C[N+](CC2=CC=CC=C2)=CC=C1\C=C\C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.502

>  <W2 Pf proliferation inhibition EC50 uM>
0.543

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1924
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    2.0367   -6.2491    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -7.0741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -7.5590    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -8.3437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -9.0111    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -8.3437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -9.0111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -8.9249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1661   -9.5923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9866   -9.5061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -8.7524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8372   -8.0849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0168   -8.1712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1426   -8.6661    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0564   -7.8457    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2289   -9.4866    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9631   -8.5799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4480   -9.2473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2685   -9.1611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6041   -8.4074    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1192   -7.7400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2987   -7.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4246   -8.3212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9095   -8.9886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7300   -8.9024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0655   -8.1487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5806   -7.4813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7601   -7.5675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -7.5590    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
  6 29  1  0  0  0  0
  2 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1924

>  <JC_XSMILES>
O=C1NC(=O)C(CC2=CC=C(C=C2)S(=O)(=O)N3CCN(CC3)C4=CC=CC=C4)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.79

>  <W2 Pf proliferation inhibition EC50 uM>
5.43

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012345679

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1928
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1928

>  <JC_XSMILES>
CCN(CC)C1=[S+]C(=CS1)C2=CC=C(Br)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.349

>  <W2 Pf proliferation inhibition EC50 uM>
0.541

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1929
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -4.2962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -4.2703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -4.2703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
  3 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  10
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  18
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1929

>  <JC_XSMILES>
COC1=CC(CNNC2=NC3=CC(Cl)=CC=C3N2)=CC(OC)=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3075

>  <W2 Pf proliferation inhibition EC50 uM>
0.541

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1930
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    3.3000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   14.2894    2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   15.0039    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 12 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 10 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 29 34  1  0  0  0  0
M  CHG  2  23   1  24  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1930

>  <JC_XSMILES>
CCOCCCNC(=O)C1=CC(NC(=O)C2=CC=C(Cl)C(=C2)[N+]([O-])=O)=CC=C1N3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.077

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.425

>  <Powder data?>
No

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1931
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1697    1.0290    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6176    1.6421    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0301    2.3566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6946    3.1102    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8371    2.1850    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
  8 13  4  0  0  0  0
  6 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  5 17  4  0  0  0  0
 17 18  4  0  0  0  0
  3 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1931

>  <JC_XSMILES>
CCC1=CC2=C(SC3=NN=C(N)S3)N=CN=C2S1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.546

>  <W2 Pf proliferation inhibition EC50 uM>
0.54

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.030769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1932
  Mrv1591402191617072D          

 13 15  0  0  0  0            999 V2000
    3.6165    0.7595    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9020    1.1720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8158    1.9925    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0088    2.1641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5963    1.4496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1483    0.8365    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7713    1.4496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2193    0.8365    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5344    1.1720    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4482    1.9925    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3588    2.1641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7713    2.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5963    2.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  7 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  4 13  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1   3
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1   6
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1932

>  <JC_XSMILES>
SC1=NC2=C(N1)C3=NSN=C3C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.713

>  <W2 Pf proliferation inhibition EC50 uM>
0.537

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1934
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -2.1434    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
  6 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
  5 31  4  0  0  0  0
 31 32  4  0  0  0  0
  2 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1934

>  <JC_XSMILES>
ClC1=CC=C2C(NCCCCNC(=O)C(C3=CC=CC=C3)C4=CC=CC=C4)=CC=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.73

>  <W2 Pf proliferation inhibition EC50 uM>
0.44

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.21

>  <Powder data?>
No

>  <IFI value>
0.037735849

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1937
  Mrv1591402191617072D          

 18 18  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1937

>  <JC_XSMILES>
CCC(CC)=NNC(=O)C(=O)NC1CCCCC1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2308

>  <W2 Pf proliferation inhibition EC50 uM>
0.535

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1938
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
   -1.0079    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2934    5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769   -1.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8220   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0150   -2.6088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4630   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7179   -1.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
  7 32  4  0  0  0  0
  3 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1938

>  <JC_XSMILES>
COC1=CC=CC(OCCN2CCN(CC2)C3=NC=NC4=C3C=NN4C5=CC=CC=C5)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
6.25

>  <W2 Pf proliferation inhibition EC50 uM>
4.05

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>75.72

>  <Powder data?>
Yes

>  <IFI value>
0.090909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1939
  Mrv1591402191617072D          

 37 39  0  0  0  0            999 V2000
   -0.7955   -0.3066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0108   -0.5616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1607   -1.3685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9453   -1.6235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1168   -2.4304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5037   -2.9825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2809   -2.7275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4524   -1.9206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6753   -3.7894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1232   -4.4025    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5357   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3427   -4.9455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4467   -6.0770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717   -4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2002   -5.8707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1354   -6.6244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9539   -6.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5535   -5.5351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 18 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 30 33  1  0  0  0  0
 11 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 34 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1939

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2N=C(C=C2NC(=O)CN(C(C)C)C(=O)C3=CC=C(C=C3)C(C)(C)C)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.675

>  <W2 Pf proliferation inhibition EC50 uM>
1.85

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
34.62

>  <Powder data?>
Yes

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1940
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164   -4.8395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -3.4105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1854   -3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8499   -3.2318    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0294   -3.3180    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 16 20  4  0  0  0  0
  2 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 21 30  1  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1940

>  <JC_XSMILES>
O=C(C1CCN(CC1)S(=O)(=O)C2=CC=CC3=NON=C23)N4CCCC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.534

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1941
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
  7 18  4  0  0  0  0
 18 19  4  0  0  0  0
  4 19  4  0  0  0  0
 12 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1941

>  <JC_XSMILES>
CCOC1=CC=C2N=C3C=CC(=CC3=C(NC)C2=C1)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2219

>  <W2 Pf proliferation inhibition EC50 uM>
0.534

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1943
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
    3.8123   -5.0434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6050   -4.8146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1995   -5.3867    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2087   -6.4163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9921   -5.1578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5866   -5.7299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3792   -5.5011    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9737   -6.0731    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7663   -5.8443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9645   -5.0434    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.3608   -6.4163    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1626   -7.2172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3700   -7.4460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1718   -8.2468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3792   -8.4756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7847   -7.9036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9921   -8.1324    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -7.1028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7755   -6.8739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1534   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7479   -6.7595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5405   -6.5307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1350   -7.1028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9276   -6.8739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5221   -7.4460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3148   -7.2172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3240   -8.2468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5313   -8.4756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3332   -9.2765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9368   -7.9036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1442   -8.1324    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.5497   -7.5604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7571   -7.7892    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 24 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 22 33  4  0  0  0  0
 33 34  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  32
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1943

>  <JC_XSMILES>
CCN(CC)CCCNC(=S)N(CC1=CC=C(F)C=C1)CC2=CC3=CC(C)=CC(C)=C3NC2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.76

>  <W2 Pf proliferation inhibition EC50 uM>
1.2

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
22.51

>  <Powder data?>
Yes

>  <IFI value>
0.117117117

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1948
  Mrv1591402191617072D          

 33 38  0  0  1  0            999 V2000
    3.6789    2.5037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4830    2.3190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0449    2.9230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8490    2.7383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0911    1.9496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8952    1.7649    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.5291    1.3456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7251    1.5303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1631    0.9263    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3214    0.1166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0695   -0.2312    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6003   -0.2842    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9963    0.2778    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2752   -0.1229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4335   -0.9326    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8115   -1.4746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0311   -1.2068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8728   -0.3972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0924   -0.1294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0659    0.6802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5562    1.2222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3365    0.9544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4948    0.1448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2525   -1.0322    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.6532   -1.7534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4781   -1.7668    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2291   -2.4610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5523   -3.2201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9303   -3.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2226   -3.3379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4073   -2.5338    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3441    1.0259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9433    1.7470    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 12 10  1  1  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 14 23  1  0  0  0  0
 18 23  4  0  0  0  0
 24 15  1  0  0  0  0
 12 24  1  0  0  0  0
 24 25  1  1  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 27 31  4  0  0  0  0
 13 32  1  1  0  0  0
  9 32  1  0  0  0  0
 32 33  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1948

>  <JC_XSMILES>
CC1=CC=C(Cl)C=C1N2C(=O)[C@@H]3[C@@H](C4N(C=CC5=CC=CC=C45)[C@@H]3C(=O)C6=CC=CS6)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.064

>  <W2 Pf proliferation inhibition EC50 uM>
0.529

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.097560976

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-195
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    5.7158    9.6536    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    9.6536    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   10.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   11.7161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   12.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   12.9536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   13.3661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   12.9536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   12.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    7.1786    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    5.9411    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.7036    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1904    4.2187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    3.4340    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5253    4.2187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    7.1786    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    8.4161    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7716    7.1831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9647    7.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5522    7.7260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1042    8.3391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  2 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
 15 25  4  0  0  0  0
 25 26  4  0  0  0  0
 12 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 28 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-195

>  <JC_XSMILES>
O=C(NCCC1=CC=CC=C1)C2=CN=C(NCCCN3C=CN=C3)N=C2NC4CCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.678

>  <W2 Pf proliferation inhibition EC50 uM>
1.716

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.69

>  <Powder data?>
No

>  <IFI value>
0.009615385

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1955
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  7  6  1  4  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
  6 18  4  0  0  0  0
 18 19  4  0  0  0  0
  3 19  4  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1955

>  <JC_XSMILES>
CC[N+]1=CC=C(C=CC2=CC=C(C=C2)N(C)C)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.409

>  <W2 Pf proliferation inhibition EC50 uM>
>4.46

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>84.88

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1956
  Mrv1591402191617072D          

 42 47  0  0  0  0            999 V2000
    0.1032    4.3256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6112    3.9131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6112    3.0881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3257    2.6756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3257    1.8506    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6583    1.3656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9132    0.5810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7382    0.5810    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9931    1.3656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7778    1.6206    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3909    1.0685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2193    0.2616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8324   -0.2905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6170   -0.0355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7886    0.7714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1755    1.3235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4283   -0.0864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3922   -0.0002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8771   -0.6676    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5416   -1.4213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2789   -1.5075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7638   -0.8401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1032    5.1506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6112    5.5631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3257    5.1506    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4119    4.3301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2189    4.1585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6314    4.8730    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0794    5.4861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2509    6.2931    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6378    6.8451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8093    7.6521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1962    8.2041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4116    7.9492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2401    7.1422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8532    6.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5545    3.4049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0695    2.7374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4051    1.9838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2256    1.8975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7105    2.5650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3749    3.3186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  4  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  7 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  1 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
 29 30  2  0  0  0  0
 30 31  1  4  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 27 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1956

>  <JC_XSMILES>
C(CCCN1C=C(SC1=NC2=CC=CC=C2)C3=CC=CC=C3)CCN4C=C(SC4=NC5=CC=CC=C5)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.739

>  <W2 Pf proliferation inhibition EC50 uM>
0.525

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1957
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2296    2.0580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0366    2.2295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4491    1.5150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8971    0.9019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 11 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
  9 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1957

>  <JC_XSMILES>
OC1=CC=CC=C1NC2=NC(NC3CCCC3)=C4C=CC=CC4=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.53

>  <W2 Pf proliferation inhibition EC50 uM>
0.877

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.71

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1958
  Mrv1591402191617072D          

 77 82  0  0  0  0            999 V2000
    3.0785    7.5825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9671    6.7651    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6194    6.2599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743    7.0445    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    7.0445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9543    6.2599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4904    5.8354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2136    6.2323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4904    5.0104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7759    4.5979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2048    4.5979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9193    5.0104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2048    3.7729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4904    3.3604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0919    4.0506    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4904    2.5354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7759    2.1229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0614    2.5354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0614    3.3604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3470    3.7729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6325    3.3604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3470    4.5979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0614    5.0104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6325    5.0104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0307    4.5677    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9819    4.9168    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2988    4.4541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6963    4.5043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4108    4.9168    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6963    3.6793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9819    3.2668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4108    3.2668    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4108    2.4418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6963    2.0293    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1253    2.0293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8397    2.4418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8397    3.2668    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5542    3.6793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2687    3.2668    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5542    4.5043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2687    4.9168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2687    5.7418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9831    4.5043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8397    4.9168    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1253    4.5043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8397    5.7418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5554    6.1522    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1253    1.2043    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4108    0.7918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6963    1.2043    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4108   -0.0332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6963   -0.4457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6963   -1.2707    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4108   -1.6832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4108   -2.5082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1253   -2.9207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8397   -2.5082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8397   -1.6832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1253   -1.2707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1253   -0.4457    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 21 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
  3 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  2  0  0  0  0
 37 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 42 43  2  0  0  0  0
 42 44  1  0  0  0  0
 44 45  1  0  0  0  0
 45 46  1  0  0  0  0
 45 47  1  0  0  0  0
 44 48  1  0  0  0  0
 48 49  1  0  0  0  0
 48 50  1  0  0  0  0
  6 50  1  0  0  0  0
 50 51  2  0  0  0  0
 39 52  1  0  0  0  0
 52 53  1  0  0  0  0
 53 54  2  0  0  0  0
 53 55  1  0  0  0  0
 55 56  4  0  0  0  0
 56 57  4  0  0  0  0
 57 58  4  0  0  0  0
 58 59  4  0  0  0  0
 59 60  4  0  0  0  0
 60 61  4  0  0  0  0
 61 62  4  0  0  0  0
 62 63  4  0  0  0  0
 58 63  4  0  0  0  0
 63 64  4  0  0  0  0
 55 64  4  0  0  0  0
 16 65  1  0  0  0  0
 65 66  1  0  0  0  0
 66 67  2  0  0  0  0
 66 68  1  0  0  0  0
 68 69  4  0  0  0  0
 69 70  4  0  0  0  0
 70 71  4  0  0  0  0
 71 72  4  0  0  0  0
 72 73  4  0  0  0  0
 73 74  4  0  0  0  0
 74 75  4  0  0  0  0
 75 76  4  0  0  0  0
 71 76  4  0  0  0  0
 76 77  4  0  0  0  0
 68 77  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1958

>  <JC_XSMILES>
CSC1SCC2N(C)C(=O)C(C)NC(=O)C(COC(=O)C(C(C)C)N(C)C(=O)C1N(C)C(=O)C(C)NC(=O)C(COC(=O)C(C(C)C)N(C)C2=O)NC(=O)C3=CN=C4C=CC=CC4=N3)NC(=O)C5=CN=C6C=CC=CC6=N5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0737

>  <W2 Pf proliferation inhibition EC50 uM>
0.524

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.346153846

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1960
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    3.5724   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  6 24  4  0  0  0  0
  2 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1960

>  <JC_XSMILES>
ClC1=CC=CC(CCNC2CCN(CC2)CCC3=CC=CC=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1699

>  <W2 Pf proliferation inhibition EC50 uM>
0.651

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.43

>  <Powder data?>
Yes

>  <IFI value>
0.0234375

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1966
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    4.7079    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769   -1.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8220   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0150   -2.6088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4630   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7179   -1.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7179    2.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4630    2.8207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0150    3.4338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8220    3.2623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769    2.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 11 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1966

>  <JC_XSMILES>
C=CCNC1=NC=NC2=C1C(=CN2C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
4.52

>  <W2 Pf proliferation inhibition EC50 uM>
5.22

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1968
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    6.3685   -5.1450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8284   -4.5214    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0984   -3.7418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5583   -3.1182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8284   -2.3387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6385   -2.1827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1786   -2.8064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9086   -3.5859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9086   -1.4032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7187   -1.2473    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3685   -0.7796    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5583   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0182   -0.3118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2081   -0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6680    0.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9381    0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3178    0.6236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5077    0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9676    1.0914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1574    0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1126    0.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2376    1.8709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0477    2.0268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3178    2.8064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1279    2.9623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6680    2.3387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3980    1.5591    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5878    1.4032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6385    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4486    0.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9887   -0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7989   -0.3118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0689    0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5288    1.0914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7187    0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1786    1.5591    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3685    1.4032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 18 29  4  0  0  0  0
 24 29  4  0  0  0  0
 11 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1968

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(=O)N(CCCC(C)NC2=CC(OC)=CC3=CC=CN=C23)CC4=CC=CC=C4OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.713

>  <W2 Pf proliferation inhibition EC50 uM>
0.2698

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.18

>  <Powder data?>
No

>  <IFI value>
0.015873016

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1970
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -1.8659    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9606    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5126    1.8088    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.3196    1.6373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8716    2.2503    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6786    2.0788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9335    1.2942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3815    0.6811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5745    0.8526    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 13 25  4  0  0  0  0
 25 26  2  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  2  0  0  0  0
 28 30  4  0  0  0  0
 12 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  27
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1970

>  <JC_XSMILES>
CN(CC1=CC=CC=C1)C2=NC3=C(N2CCCSC4=NC=CC=N4)C(=O)NC(=O)N3C

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
5.19

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027027027

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1971
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -3.7852   -2.8510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5151   -3.6305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7050   -3.7864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4350   -4.5660    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6248   -4.7219    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0847   -4.0983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2746   -4.2542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2655   -3.6305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0756   -3.7864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3548   -5.5014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5446   -5.6574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0046   -5.0337    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2746   -6.4369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8147   -7.0605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5446   -7.8401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0847   -8.4637    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.2655   -7.9960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8056   -7.3724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5355   -6.5928    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1935   -6.0951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2639   -5.2731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0109   -4.9231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6876   -5.3950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4346   -5.0449    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.6172   -6.2170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8702   -6.5670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6304   -7.3564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1281   -8.0144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8072   -8.7744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3049   -9.4323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9840  -10.1924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1653  -10.2944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8444  -11.0544    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.6676   -9.6365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9885   -8.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 26 27  1  0  0  0  0
 18 27  1  0  0  0  0
 27 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1971

>  <JC_XSMILES>
CCCCN(CCCC)CC(O)C1=CC(Cl)=CC2=C1C3=CC=C(Cl)C=C3\C2=C\C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.777

>  <W2 Pf proliferation inhibition EC50 uM>
0.518

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.014492754

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1974
  Mrv1591402191617072D          

 32 33  0  0  0  0            999 V2000
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -6.1875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.7474   -6.1875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717    0.5230    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.4467    1.9520    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
  6 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1974

>  <JC_XSMILES>
CON(C)C=C(C(=O)NC1=CC=C(C=C1)C(F)(F)F)C(=O)NC2=CC=C(C=C2)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.659

>  <W2 Pf proliferation inhibition EC50 uM>
0.515

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.038961039

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1976
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1976

>  <JC_XSMILES>
CN(C)CCCNCC1=CC(=CC=C1O)C2=CC=CN=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2409

>  <W2 Pf proliferation inhibition EC50 uM>
0.514

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017094017

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1978
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  8 18  4  0  0  0  0
 12 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1978

>  <JC_XSMILES>
CC(CCCO)NC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.561

>  <W2 Pf proliferation inhibition EC50 uM>
0.513

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.048780488

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1979
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 10 23  4  0  0  0  0
 14 23  4  0  0  0  0
  8 24  4  0  0  0  0
 24 25  4  0  0  0  0
  5 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1979

>  <JC_XSMILES>
CC(C)NC1=CC=C(NC2=CC=NC3=CC4=CC=CC=C4C=C23)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0318

>  <W2 Pf proliferation inhibition EC50 uM>
0.2765

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.4

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-198
  Mrv1591402191617072D          

 44 49  0  0  1  0            999 V2000
    3.1608    5.6736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7739    5.1216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5585    5.3766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1716    4.8245    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9562    5.0795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5693    4.5274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3978    3.7205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6132    3.4655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0001    4.0175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0109    3.1684    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8178    3.3400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2303    2.6255    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.6783    2.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    2.3479    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0508    2.5392    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.5358    3.2067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3562    3.1204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8412    3.7879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6616    3.7016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9972    2.9480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8177    2.8617    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.3026    3.5292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1231    3.4429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.6080    4.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.4285    4.0241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7640    3.2705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2791    2.6030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.4586    2.6893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5123    2.2805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6918    2.3668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  1  0  0  0  0
 14 13  1  0  0  0  0
 14 10  1  0  0  0  0
 14 15  1  1  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
 12 29  1  1  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
 34 43  4  0  0  0  0
 43 44  4  0  0  0  0
 31 44  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-198

>  <JC_XSMILES>
CCCN1CCC(CC1)N2C[C@H](C[C@H]2C(=O)NCCC3=CC=C4OCOC4=C3)NCC5=CC=C(OCC6=CC=CC=C6)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.067

>  <W2 Pf proliferation inhibition EC50 uM>
0.701

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.56

>  <Powder data?>
Yes

>  <IFI value>
0.097087379

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1982
  Mrv1591402191617072D          

 33 34  0  0  0  0            999 V2000
    1.5466   -6.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3662   -5.9376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5301   -7.3571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7105   -7.4517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6774   -6.5054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1692   -7.1678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9887   -7.0732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4805   -7.7356    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3000   -7.6410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6278   -6.8839    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.7917   -8.3034    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6113   -8.2088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9391   -7.4517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7587   -7.3571    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2504   -8.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0700   -7.9249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0865   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9061   -6.5054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4639   -9.0605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9557   -9.7229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7752   -9.6283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2669  -10.2907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0865  -10.1961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5782  -10.8585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2504  -11.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7421  -12.2780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4309  -11.7102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1030  -12.4673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9391  -11.0478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1196  -11.1424    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6278  -10.4800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8083  -10.5746    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 12 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 23 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 21 32  4  0  0  0  0
 32 33  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  31
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1982

>  <JC_XSMILES>
CCN(CC)CCCNC(=S)N(CCN(CC)CC)CC1=CC2=CC=C(C)C(C)=C2NC1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
3.28

>  <W2 Pf proliferation inhibition EC50 uM>
>2.606

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
51.12

>  <Powder data?>
Yes

>  <IFI value>
0.021052632

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1984
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    4.2868    1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4618    0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1118    0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 21 22  1  0  0  0  0
 13 23  4  0  0  0  0
 23 24  2  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 11 26  4  0  0  0  0
 25 27  1  0  0  0  0
 27 28  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1984

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(=C1)C2=CN(CC3=C(Cl)C=CC=C3Cl)C(=O)C(=C2)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
>7.43

>  <W2 Pf proliferation inhibition EC50 uM>
5.08

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.052631579

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1985
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -1.1439   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0936   -3.8913    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.9186   -3.8913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3311   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9186   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0936   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -6.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1439   -6.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5564   -6.7491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5564   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1439   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3311   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1561   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6410   -2.5093    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3861   -1.7247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9381   -1.1116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4256   -2.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1401   -2.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8546   -2.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5691   -2.3518    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5691   -1.5268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8546   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1401   -4.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4256   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6410   -3.8442    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  3 13  4  0  0  0  0
  7 13  4  0  0  0  0
  4 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 19 26  4  0  0  0  0
 26 27  1  0  0  0  0
 15 27  1  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1985

>  <JC_XSMILES>
CCN1C(\C=CC2=CC(C)=CC=C12)=C\C3=[N+](CC)C4=CC(OC)=CC=C4S3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.431

>  <W2 Pf proliferation inhibition EC50 uM>
0.508

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.230769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1989
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -2.2168   -5.2354    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.5023   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5023   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3429   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878   -6.0604    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  4  0  0  0  0
 14 15  2  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
  5 21  4  0  0  0  0
 21 22  4  0  0  0  0
  2 22  4  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1989

>  <JC_XSMILES>
ClC1=CC=C(CN2C3=C(CCCC3)C(=N)C4=C2CCC4)C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.503

>  <W2 Pf proliferation inhibition EC50 uM>
0.506

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1990
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -5.9016    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
  5 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  CHG  3   8   1   9  -1  13   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1990

>  <JC_XSMILES>
CC1=CC=C(C=C1[N+]([O-])=O)C2=CN3C=CC=CC3=[N+]2CC(=O)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.369

>  <W2 Pf proliferation inhibition EC50 uM>
0.506

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1991
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4760   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8109   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  3  7  1  0  0  0  0
  2  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  2  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 24 25  4  0  0  0  0
 14 25  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  25
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1991

>  <JC_XSMILES>
CN(C1CCCC1)C2CCN(CC2)C3=CC(C)=C4C=CC(O)=CC4=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3124

>  <W2 Pf proliferation inhibition EC50 uM>
1.286

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
25.46

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1992
  Mrv1591402191617072D          

 39 44  0  0  0  0            999 V2000
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  2  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  4  0  0  0  0
 23 33  4  0  0  0  0
 19 34  4  0  0  0  0
 34 35  4  0  0  0  0
  8 35  4  0  0  0  0
 16 35  4  0  0  0  0
  6 36  4  0  0  0  0
 36 37  4  0  0  0  0
  3 37  4  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1992

>  <JC_XSMILES>
COC1=CC=C(NC2=C3CCCCC3=NC4=CC=C(NC(=O)C5=CC(=O)C6=CC=CC=C6O5)C=C24)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3034

>  <W2 Pf proliferation inhibition EC50 uM>
0.558

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.06

>  <Powder data?>
Yes

>  <IFI value>
0.114285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1993
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  4 17  4  0  0  0  0
  8 17  4  0  0  0  0
  1 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1993

>  <JC_XSMILES>
C(CNC1=CC=NC2=CC3=CC=CC=C3C=C12)CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1992

>  <W2 Pf proliferation inhibition EC50 uM>
0.2088

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.14

>  <Powder data?>
Yes

>  <IFI value>
0.136363636

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1994
  Mrv1591402191617072D          

 31 35  0  0  1  0            999 V2000
   -5.7528   -1.0370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9991   -0.7015    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3317   -1.1864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5780   -0.8509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9106   -1.3358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9968   -2.1563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3294   -2.6412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -2.3056    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042   -1.4986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2481   -2.1661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612   -2.7181    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.7750   -3.5386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4424   -4.0235    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0213   -3.8742    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6461   -3.3892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9817   -2.6356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4666   -3.3030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7505   -2.4918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4179   -2.0069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1716   -2.3424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12  8  1  0  0  0  0
 12 13  1  1  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 18  1  0  0  0  0
 10 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
  6 29  4  0  0  0  0
 29 30  4  0  0  0  0
  3 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  28
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1994

>  <JC_XSMILES>
COC1=CC=C(CN2C[C@@H](C[C@H]2C(=O)NC3CC3)SC4=NC5=CC=CC=C5N4)C=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.545

>  <W2 Pf proliferation inhibition EC50 uM>
0.83

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.49

>  <Powder data?>
Yes

>  <IFI value>
0.144067797

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1998
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 16 22  4  0  0  0  0
  3 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1998

>  <JC_XSMILES>
CCC(C(=O)N(C)CCCNC1=CC=NC2=CC(Cl)=CC=C12)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3109

>  <W2 Pf proliferation inhibition EC50 uM>
0.3102

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.17

>  <Powder data?>
No

>  <IFI value>
0.02970297

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2000
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -4.9355   -5.3245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3421   -4.7514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4569   -3.9345    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7154   -3.5728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5721   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7969   -2.4782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1649   -3.0085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6536   -1.6657    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2856   -1.1354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1424   -0.3230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3671   -0.0408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7351   -0.5711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9599   -0.2889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3279   -0.8192    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4474   -0.5371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5906    0.2754    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0793   -1.0674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5815   -1.7219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7635   -1.8295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5525   -0.3916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2039    0.3562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6772    1.0319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4990    0.9600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9722    1.6358    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8477    0.2123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3744   -0.4635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8784   -1.3836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1423   -4.1663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5296   -4.8947    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 12 27  1  0  0  0  0
  8 27  1  0  0  0  0
  4 28  4  0  0  0  0
 28 29  4  0  0  0  0
  2 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2000

>  <JC_XSMILES>
CC1=NC(CC(=O)N2CCCC(CNC(=O)C3(CC3)C4=CC=C(Cl)C=C4)C2)=CS1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
5.02

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2003
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -8.2500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -9.4875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -9.4875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  2  0  0  0  0
 28 30  4  0  0  0  0
 20 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2003

>  <JC_XSMILES>
CCCCCCCCC(=O)N1CCN(CC1)C(CC)C2=NC3=CC=CC=C3C(=O)N2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.492

>  <W2 Pf proliferation inhibition EC50 uM>
0.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.021052632

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2005
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8020    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6090    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0215    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8420    0.1913    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    6.4694   -0.3356    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 18 23  4  0  0  0  0
 14 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 12 26  4  0  0  0  0
 26 27  4  0  0  0  0
  8 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2005

>  <JC_XSMILES>
CN1CCN(CC1)C2=CC(C)=C3C=C(NC(=O)C4=CC=C(Br)O4)C=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.68

>  <W2 Pf proliferation inhibition EC50 uM>
2.682

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
53.68

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2006
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2006

>  <JC_XSMILES>
OC(CNC1CCN(CC1)CC2=CC=CC=C2)COC3=CC=C(Br)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.745

>  <W2 Pf proliferation inhibition EC50 uM>
0.499

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008264463

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2009
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -1.7013   -1.2950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9562   -0.5103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042    0.1028    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.5757    0.9097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612    1.3222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481    0.7702    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7750    2.1427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4424    2.6276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3562    3.4481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6025    3.7837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5163    4.6042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0649    3.2988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0213    2.4783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  3  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
  9 18  1  0  0  0  0
  5 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2009

>  <JC_XSMILES>
CCN1C=C(S\C1=C/C2=[N+](C)C3=CC=CC=C3S2)C4=CC=C(C)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.362

>  <W2 Pf proliferation inhibition EC50 uM>
0.938

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.85

>  <Powder data?>
Yes

>  <IFI value>
0.147058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2010
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    6.2102    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -0.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -0.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 17 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2010

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2=CC=C3C(N)=C(SC3=N2)C(=O)NCCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>10.8

>  <W2 Pf proliferation inhibition EC50 uM>
4.97

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.072727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2011
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    5.4223    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769    2.4777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7179    2.0361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4630    2.8207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0150    3.4338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7601    4.2184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0469    4.3900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3018    5.1746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5989    3.7769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3440    2.9922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8960    2.3791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  3 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 17 22  4  0  0  0  0
 19 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2011

>  <JC_XSMILES>
CCN(CC1=CC=CC=C1)CC2=C(O)C=CC3=C2C(=C(C)O3)C(=O)NC4=CC=C(C)C=C4C

>  <PF proliferation inhibition 3D7 EC50 uM>
3.49

>  <W2 Pf proliferation inhibition EC50 uM>
2.1

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
42.29

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2013
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  5 11  4  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  3 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 21 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2013

>  <JC_XSMILES>
CCC(SC1=NC(C)=CC(=N1)C2=CC=CC=C2)C(=O)NC3=CC=CC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.496

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2016
  Mrv1591402191617072D          

 34 37  0  0  1  0            999 V2000
   -3.6468   -8.6009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7330   -7.7804    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0656   -7.2955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1518   -6.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4844   -5.9901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7307   -6.3257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0632   -5.8407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1495   -5.0203    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.9032   -4.6847    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4820   -4.5353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2716   -4.8709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5683   -3.7149    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0992   -3.2299    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.0992   -2.4049    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.5683   -1.9200    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.3687   -2.8174    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -3.4849    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1387   -4.2695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9457   -4.4410    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6444   -7.1462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3119   -7.6311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  0  0  0  0
  8  9  1  6  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 13 12  1  1  0  0  0
 13 14  1  0  0  0  0
 14 15  1  1  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 18 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 16 21  1  6  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 21 29  4  0  0  0  0
 24 29  4  0  0  0  0
 25 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
  6 33  4  0  0  0  0
 33 34  4  0  0  0  0
  3 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2016

>  <JC_XSMILES>
COC1=CC=C(C[C@H](N)C(=O)N[C@H]2[C@@H](O)[C@@H](O[C@@H]2CO)N3C=NC4=C(N=CN=C34)N(C)C)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.611

>  <W2 Pf proliferation inhibition EC50 uM>
0.328

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.63

>  <Powder data?>
No

>  <IFI value>
0.307692308

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2020
  Mrv1591402191617072D          

 28 29  0  0  0  0            999 V2000
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 16 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 28  4  0  0  0  0
 13 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2020

>  <JC_XSMILES>
CCN(CC)CCCC(C)NCC1=CC=C(OCC2=CC=CC=C2)C(OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.771

>  <W2 Pf proliferation inhibition EC50 uM>
0.494

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2024
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    5.0013    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 10 22  1  0  0  0  0
 22 23  2  0  0  0  0
 21 24  4  0  0  0  0
 13 24  4  0  0  0  0
 17 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2024

>  <JC_XSMILES>
ONC(=O)CCCCCN1C(=O)C2=CC=CC3=CC=CC(C1=O)=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.563

>  <W2 Pf proliferation inhibition EC50 uM>
0.164

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.32

>  <Powder data?>
Yes

>  <IFI value>
0.194244604

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2027
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2027

>  <JC_XSMILES>
C=CCOC1=CC=CC=C1CN2CCN(CC2)C3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.99

>  <W2 Pf proliferation inhibition EC50 uM>
4.85

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>98.53

>  <Powder data?>
Yes

>  <IFI value>
0.029850746

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2029
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    5.0812   -6.3898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6687   -5.6753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8437   -5.6753    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4312   -4.9609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6062   -4.9609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1937   -4.2464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6062   -3.5319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4312   -3.5319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8437   -4.2464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1937   -2.8174    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3687   -2.8174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -3.4849    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0992   -3.2299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5683   -3.7149    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0992   -2.4049    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
 10  7  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 16 15  1  4  0  0  0
 11 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 17 27  1  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2029

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)N=C2NC(=O)SC2=C3C(=O)NC4=CC=C(Br)C=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.91

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2030
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  6 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
  4 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2030

>  <JC_XSMILES>
CN(C)C1=CC(NC(=O)NC2=CC=CC=C2)=C3C=CC=CC3=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1482

>  <W2 Pf proliferation inhibition EC50 uM>
0.332

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.78

>  <Powder data?>
Yes

>  <IFI value>
0.022556391

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2031
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
  3 22  4  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2031

>  <JC_XSMILES>
COC1=CC(CN2CCN(CC2)C3=CC=CC=N3)=CC(I)=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.9

>  <W2 Pf proliferation inhibition EC50 uM>
4.89

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2033
  Mrv1591402191617072D          

 26 28  0  0  1  0            999 V2000
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 13 12  1  0  0  0  0
 13  8  1  0  0  0  0
 13 14  1  6  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 11 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2033

>  <JC_XSMILES>
COCCNCCN1CCN(C[C@@H]1C2=CC=CC=C2)C3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.436

>  <W2 Pf proliferation inhibition EC50 uM>
0.548

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.21

>  <Powder data?>
No

>  <IFI value>
0.012345679

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2034
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 10 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
  8 24  4  0  0  0  0
  6 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2034

>  <JC_XSMILES>
OC1=CC=CC(NC2=NC(NCC3CCCO3)=C4C=CC=CC4=N2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2655

>  <W2 Pf proliferation inhibition EC50 uM>
0.341

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.98

>  <Powder data?>
Yes

>  <IFI value>
0.015873016

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2038
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  3  8  1  0  0  0  0
  6  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  1  0  0  0  0
M  CHG  1  19   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2038

>  <JC_XSMILES>
CCN1C=CC(C=C1)=CC2=CC=C3C=CC=CC3=[N+]2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.453

>  <W2 Pf proliferation inhibition EC50 uM>
0.976

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.01

>  <Powder data?>
Yes

>  <IFI value>
0.030769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2040
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  2  0  0  0  0
  8 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 25 30  1  0  0  0  0
  6 31  4  0  0  0  0
 31 32  4  0  0  0  0
  3 32  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2040

>  <JC_XSMILES>
COC1=CC=C(CN(CC2=CC3=CC=CC(C)=C3NC2=O)C(=S)NC4CCCCC4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.487

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.036036036

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2041
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
  4 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
M  CHG  4   1  -1   2   1  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2041

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C(=O)N2CCCCC2)C(=C1)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.86

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2043
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3088   -3.6695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6444   -2.9158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1595   -2.2483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3390   -2.3346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8541   -1.6671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1896   -0.9135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4559   -4.0144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1203   -4.7681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 11 10  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  4  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 14 24  1  0  0  0  0
 24 25  1  0  0  0  0
 12 25  1  0  0  0  0
 25 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2043

>  <JC_XSMILES>
CCOC1=CC=C(Br)C=C1C=C2SC(=NC3=CC=CC=C3CC)N(C2=O)C4=CC=CC=C4CC

>  <PF proliferation inhibition 3D7 EC50 uM>
8.33

>  <W2 Pf proliferation inhibition EC50 uM>
4.86

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2044
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -4.2703    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 15 24  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2044

>  <JC_XSMILES>
OC(=O)C1=CC=C(Cl)C=C1NC(=O)CN2C(=O)C3=CC=CC=C3C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.486

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2046
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -0.4894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.1025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -1.8170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731   -1.6455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  1  0  0  0  0
  6 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  5 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2046

>  <JC_XSMILES>
ClC1=CC=C2C(NCCCCNC(=O)C3CCCC3)=CC=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.409

>  <W2 Pf proliferation inhibition EC50 uM>
0.485

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009174312

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2048
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 18 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2048

>  <JC_XSMILES>
COC1=CC=C(C=C1)S(=O)(=O)NCCCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.345

>  <W2 Pf proliferation inhibition EC50 uM>
0.484

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2050
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    2.3075   -0.3948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8774    0.2017    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6788    0.0065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6322    1.0395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2404    1.7984    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7474    1.6852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1640    0.7396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860    0.8095    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5177    1.4402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3363    0.9299    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4478    2.2622    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1804    2.6414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2184    3.4655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9510    3.8446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6457    3.3998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6078    2.5756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8751    2.1964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8171    2.7940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6391    3.6412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9951    2.7240    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4634    2.0934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2835    2.4437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9603    1.9722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8903    1.1502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1436    0.7998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5333    1.2714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 11 18  1  0  0  0  0
  6 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  7 26  1  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2050

>  <JC_XSMILES>
CN(C)C(=O)C1C2NC(=S)N(C3=CC=CC=C3)C1(C)OC4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
1.752

>  <W2 Pf proliferation inhibition EC50 uM>
0.483

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2056
  Mrv1591402191617072D          

 50 56  0  0  0  0            999 V2000
   -0.7972   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3847   -6.2980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4403   -6.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8528   -5.5836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6778   -5.5836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0903   -6.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9153   -6.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3278   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1528   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6377   -6.3451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3828   -5.5604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9947  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9947  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7092  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7092  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4236  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1381  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1381  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4236  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9947  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7092  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7092  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9947  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513  -14.0250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658  -12.7875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6377   -7.6799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3828   -8.4646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6778   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8528   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4403   -7.7270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3847   -7.7270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 25 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  2  0  0  0  0
 38 40  4  0  0  0  0
 24 40  4  0  0  0  0
 20 41  4  0  0  0  0
 41 42  4  0  0  0  0
 17 42  4  0  0  0  0
 15 43  4  0  0  0  0
 43 44  4  0  0  0  0
 12 44  4  0  0  0  0
 44 45  1  0  0  0  0
  9 45  1  0  0  0  0
 45 46  2  0  0  0  0
  6 47  4  0  0  0  0
 47 48  4  0  0  0  0
  3 48  4  0  0  0  0
 48 49  1  0  0  0  0
 49 50  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2056

>  <JC_XSMILES>
COC1=CC=C(CCN2C(=O)C3=CC=C(OC4=CC=C(NC(=O)C5=C(C6=CC=CC=C6)C7=CC=CC=C7C(=O)O5)C=C4)C=C3C2=O)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.8

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2060
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8653    0.4014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6499    0.6563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8214    1.4633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2083    2.0153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4237    1.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2522    0.9534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1226   -5.8442    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3052   -4.6919    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9703   -5.6617    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  9 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2060

>  <JC_XSMILES>
CCOC(=O)C1CSC(N1C(=O)\C=C\C2=CC=CC=C2)C3=CC=C(C=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.343

>  <W2 Pf proliferation inhibition EC50 uM>
0.381

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>7.95

>  <Powder data?>
No

>  <IFI value>
0.028301887

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2061
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -8.6625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
  9 23  4  0  0  0  0
  3 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2061

>  <JC_XSMILES>
COC1=CC(OC)=NC(CSC2=CC=C(NC(=O)CCl)C=C2)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.518

>  <W2 Pf proliferation inhibition EC50 uM>
0.479

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2066
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 10 23  4  0  0  0  0
 14 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2066

>  <JC_XSMILES>
CCN1CCC(CC1)NC2=CC=NC3=CC4=CC=CC=C4C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0815

>  <W2 Pf proliferation inhibition EC50 uM>
0.477

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.090909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2070
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
    3.2789    4.5375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9947    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9947    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
  8 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
  9 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2070

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C2N(CCC3=C2NC=N3)C(=O)NC4=CC=C(C=C4)N5CCCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.64

>  <W2 Pf proliferation inhibition EC50 uM>
0.2386

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>5.04

>  <Powder data?>
No

>  <IFI value>
0.022988506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2074
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2074

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C(=O)CN2C=CC(C=C2)=NCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2962

>  <W2 Pf proliferation inhibition EC50 uM>
0.602

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.77

>  <Powder data?>
Yes

>  <IFI value>
0.044117647

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2078
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  5 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2078

>  <JC_XSMILES>
OCCNC1=NC(NC2=CC=C(Br)C=C2)=NC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.49

>  <W2 Pf proliferation inhibition EC50 uM>
0.566

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.05

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2079
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599   -3.6020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849   -2.1730    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
  4 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
  2 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2079

>  <JC_XSMILES>
CC1=CC(NC2=CC=CC(=C2)C(F)(F)F)=NC(N)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.676

>  <W2 Pf proliferation inhibition EC50 uM>
1.859

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
39.58

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-208
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    2.7845   -2.6021    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.7771    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  7 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 17 24  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-208

>  <JC_XSMILES>
ClC1=CC=C(NC2=NC3=NON=C3N=C2NC4=CC=C(Cl)C(Cl)=C4)C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
9.28

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.7

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2083
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2448   -1.0445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9592   -1.4570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9592   -2.2820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2448   -2.6945    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5303   -2.2820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5303   -1.4570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2448   -3.5195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9592   -3.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9592   -4.7570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2448   -5.1695    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5303   -4.7570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5303   -3.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2448   -5.9945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5303   -6.4070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5303   -7.2320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1842   -7.6445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8986   -7.2320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8986   -6.4070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1842   -5.9945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7751   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4929    0.3627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0232    0.9947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8357    0.8515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3660    1.4835    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.1178    0.0762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5875   -0.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  2 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2083

>  <JC_XSMILES>
OC1(CCN(CC1)C2CCN(CC2)CC3=CC=CC=C3)C4=CC=C(Br)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1833

>  <W2 Pf proliferation inhibition EC50 uM>
0.433

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.26

>  <Powder data?>
Yes

>  <IFI value>
0.015748031

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2086
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    4.8951    4.7541    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2903    4.1930    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.5020    4.4361    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4739    3.3886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2622    3.1455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4458    2.3412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8410    1.7800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0527    2.0232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4479    1.4620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6315    0.6577    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4358    0.4742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9502    1.1192    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7938   -0.2691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4358   -1.0124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6315   -1.1960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4479   -2.0003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0527   -2.5615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8691   -3.3658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0808   -3.6090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4760   -3.0478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6596   -2.2435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0548   -1.6824    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.9865   -0.6816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -1.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5575   -0.6816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8431   -1.0941    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.5575    0.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720    0.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9865    0.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8691    2.8275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 15 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 10 29  1  0  0  0  0
 23 29  4  0  0  0  0
  8 30  4  0  0  0  0
  4 30  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2086

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(CN2C(=O)CN=C(C3=CC=CC=C3Cl)C4=CC(Cl)=CC=C24)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>4.47

>  <W2 Pf proliferation inhibition EC50 uM>
>4.67

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.019230769

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2092
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.3020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
    2.3645   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  4 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  4 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2092

>  <JC_XSMILES>
C\C=C\[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0528

>  <W2 Pf proliferation inhibition EC50 uM>
0.13

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.809

>  <Powder data?>
Yes

>  <IFI value>
0.117647059

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2093
  Mrv1591402191617072D          

 42 46  0  0  0  0            999 V2000
   -1.0971    2.1534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5570    2.7770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2531    2.6211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7932    3.2448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6033    3.0889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9535    3.5566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2236    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4936    4.1802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3038    4.0243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8439    4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6540    4.4921    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1941    5.1157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0042    4.9598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5443    5.5834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3544    5.4275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6245    4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0844    4.0243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2743    4.1802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4346    4.4921    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.9747    5.1157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7047    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9240    3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1445    3.4425    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7036    3.9825    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1941    2.9329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0042    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2743    1.9975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7342    1.3738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9240    1.5298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3839    0.9061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5738    1.0620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3038    1.8416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8439    2.4652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6540    2.3093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8734    2.3093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6835    2.1534    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9535    1.3738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4135    0.7502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6033    0.9061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3333    1.6857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5231    1.8416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 12 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 26 35  4  0  0  0  0
 30 35  4  0  0  0  0
  5 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 36 41  4  0  0  0  0
 41 42  4  0  0  0  0
  3 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2093

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=C(C=C2)N(C)C)S(=O)(=O)C3=CC=CC4=CC=CC=C34)=C5N=CC=CC5=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.806

>  <W2 Pf proliferation inhibition EC50 uM>
0.645

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>13.94

>  <Powder data?>
No

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2094
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  4 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 13 22  4  0  0  0  0
  2 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2094

>  <JC_XSMILES>
CC1=CC(NC2CCCCC2)=NC(NCC3=CC=CC=C3)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.296

>  <W2 Pf proliferation inhibition EC50 uM>
0.364

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.87

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2096
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 20 29  4  0  0  0  0
 11 29  4  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2096

>  <JC_XSMILES>
CN(CC1COCCO1)CC2=CC3=CC=C(F)C=C3N(CCN4CCCCC4)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.62

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.019607843

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2098
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731    0.8205    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800    0.9920    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4130    0.1913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2335    0.1051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3268   -0.6292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4993    1.0118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 11 24  4  0  0  0  0
 24 25  2  0  0  0  0
 24 26  4  0  0  0  0
  8 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2098

>  <JC_XSMILES>
CCOC1=CC=CC2=C1C=C(C(=O)NC3=NOC(=C3)C(C)(C)C)C(=O)O2

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.66

>  <W2 Pf proliferation inhibition EC50 uM>
>4.62

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-210
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    0.7009    4.7007    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.3683    5.1856    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.2821    6.0061    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1220    4.8501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7895    5.3350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5431    4.9994    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6294    4.1789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9619    3.6940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2083    4.0296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    3.8434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975    4.2559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7106    3.7038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3751    2.9502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5546    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0025    2.4233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1956    2.5948    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435    1.9817    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 15 14  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
 25 30  4  0  0  0  0
 22 30  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-210

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)N2C=CC=C2C=NNC3=NC=NC4=C3C5=C(CCCC5)S4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.78

>  <W2 Pf proliferation inhibition EC50 uM>
1.407

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.45

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2100
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -5.0224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -5.8070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -5.8070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -5.0224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  2 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2100

>  <JC_XSMILES>
CC(NS(=O)(=O)C1=CC=CC=C1)C(=O)NC2CCCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
>4.32

>  <W2 Pf proliferation inhibition EC50 uM>
4.62

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2102
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 11 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  9 24  4  0  0  0  0
 24 25  4  0  0  0  0
  6 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2102

>  <JC_XSMILES>
CCOC(=O)C1=CC=C2N=C3C(=O)C4=CC=CC=C4C(=O)C3=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02674

>  <W2 Pf proliferation inhibition EC50 uM>
0.02362

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.512

>  <Powder data?>
Yes

>  <IFI value>
0.219512195

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2105
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 20 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2105

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC(Cl)=CC(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2351

>  <W2 Pf proliferation inhibition EC50 uM>
0.46

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017094017

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2108
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
 12 13  1  0  0  0  0
  6 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 29 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2108

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N(C(C)=C(C1C2=CC=C(Br)C=C2)C(=O)OCC)C3=CC=C(C=C3)N(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.129

>  <W2 Pf proliferation inhibition EC50 uM>
0.896

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.56

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2109
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -3.4656   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380    0.7634    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -5.0116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0837   -5.4965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3387   -6.2812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1637   -6.2812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4186   -5.4965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  6 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  1 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 23 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2109

>  <JC_XSMILES>
C(CNC1=CC(=NC(=N1)C2=CC=CC=C2)C3=CC=NC=C3)CN4C=CN=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2376

>  <W2 Pf proliferation inhibition EC50 uM>
0.458

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-211
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    2.2757   -1.3521    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2757   -2.1771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9902   -2.5896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9902   -3.4146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2757   -3.8271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5613   -3.4146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5613   -2.5896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8468   -2.1771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1323   -2.5896    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8468   -1.3521    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1323   -0.9396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5821   -1.3521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2966   -0.9396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2966   -0.1146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5821    0.2979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1323   -0.1146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0111    0.2979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7256    0.7104    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4236   -0.4166    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5986    1.0123    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2757   -4.6521    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4507   -4.6521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1007   -4.6521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2757   -5.4771    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5613   -5.8896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6229   -6.7123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0181   -7.2735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2024   -7.1505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2101   -6.4360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0913   -5.6681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8796   -5.4249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
  5 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 25 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-211

>  <JC_XSMILES>
FC1=CC=C(C=C1C(=O)NC2=CC=C(C=C2)C(F)(F)F)S(=O)(=O)NC3CCCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
4

>  <W2 Pf proliferation inhibition EC50 uM>
3.33

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.68

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2111
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9645   -4.3576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7715   -4.1861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0264   -3.4015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4744   -2.7884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  3 11  1  0  0  0  0
  6 11  4  0  0  0  0
  2 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2111

>  <JC_XSMILES>
O=C(N1CCC2=CC=CC=C12)C3=CC=C4C=CC=CC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
3.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.57

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2112
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752    0.3126    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429    4.0641    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710    3.7211    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  2  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 13 20  4  0  0  0  0
  9 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  6 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2112

>  <JC_XSMILES>
CN(C)CCN1C(=N)N(CC(O)C2=CC=C(Cl)C(Cl)=C2)C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2564

>  <W2 Pf proliferation inhibition EC50 uM>
0.457

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2113
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
   -1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0468   -5.0081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -3.7706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3822   -5.0081    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0966   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0966   -3.7706    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8111   -5.0081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8973   -5.8286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7043   -6.0001    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.1168   -5.2856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5648   -4.6725    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7363   -3.8656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5209   -3.6106    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1232   -3.3135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3386   -3.5685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7255   -3.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0591   -3.2714    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6722   -2.7193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8970   -2.2095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2839   -1.6574    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4554   -0.8505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6816   -1.9545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.1476    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.8926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2947   -2.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9373   -5.1994    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2728   -4.4457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0933   -4.3595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5782   -5.0269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2427   -5.7806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7276   -6.4480    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.4222   -5.8668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
 15 26  4  0  0  0  0
 11 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 27 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2113

>  <JC_XSMILES>
CCC(C)NC(=O)C1CSC(N1C(=O)C2=CC(OC)=C(OC)C(OC)=C2)C3=CC=CC(F)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.02984

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>0.654

>  <Powder data?>
No

>  <IFI value>
0.019230769

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2114
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -13.6125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -16.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -16.5000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -16.5000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -17.3250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -17.7375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -18.5625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -18.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -19.8000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -20.2125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -19.8000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -18.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2114

>  <JC_XSMILES>
CN1CCC(CC1)N2CCC(CC2)OC3=CC=CC(=C3)C(=O)NCCC4=CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.78

>  <W2 Pf proliferation inhibition EC50 uM>
0.944

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.73

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2118
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 11 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
  9 25  4  0  0  0  0
  7 26  4  0  0  0  0
 26 27  4  0  0  0  0
  4 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2118

>  <JC_XSMILES>
CCOC1=CC=C(NC2=NC(NCC3=CC=CO3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2877

>  <W2 Pf proliferation inhibition EC50 uM>
0.528

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.62

>  <Powder data?>
Yes

>  <IFI value>
0.038461538

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2121
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -0.4441    0.2957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3683    0.4390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8986   -0.1930    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7111   -0.0498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9933    0.7255    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2414   -0.6817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2414   -2.3317    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5269   -1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5269   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2414   -3.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -3.5692    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5269   -3.5692    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5269   -4.3942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2414   -4.8067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2414   -5.6317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5269   -6.0442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8125   -5.6317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0980   -6.0442    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0980   -6.8692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8125   -4.8067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7717   -0.0498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5842   -0.1930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1145    0.4390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9269    0.2957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2091   -0.4795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6788   -1.1115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8663   -0.9683    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 15 22  4  0  0  0  0
  6 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2121

>  <JC_XSMILES>
CCOC(=O)C1(CCN(CC1)C(=O)NC2=CC=CC(SC)=C2)CC3CCCCO3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.53

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2123
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 15 21  4  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2123

>  <JC_XSMILES>
ClC1=CC=C2C(NCCCCNC(=O)C3=CC=CC(Br)=C3)=CC=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.422

>  <W2 Pf proliferation inhibition EC50 uM>
0.453

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.00952381

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2124
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  2  0  0  0  0
  3  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
  8 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
  7 23  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2124

>  <JC_XSMILES>
CCN(C(C)=O)C1=C(N2CCOCC2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1684

>  <W2 Pf proliferation inhibition EC50 uM>
0.1849

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.09

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2125
  Mrv1591402191617072D          

 28 31  0  0  1  0            999 V2000
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    8.8806   -3.2816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4043   -3.5566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  8  7  1  6  0  0  0
  9  8  1  6  0  0  0
  9 10  1  0  0  0  0
 11 10  1  1  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 16 15  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  1  0  0  0
 17 18  2  0  0  0  0
  8 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 19 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2125

>  <JC_XSMILES>
CCCCC(=O)O[C@@H]([C@@H]1C[C@@H]2CCN1C[C@@H]2C=C)C3=CC=NC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.942

>  <W2 Pf proliferation inhibition EC50 uM>
0.452

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.04587156

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2128
  Mrv1591402191617072D          

 18 18  0  0  0  0            999 V2000
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -7.8375    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2128

>  <JC_XSMILES>
CCCCNCCOCCOC1=CC=C(Br)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.7

>  <W2 Pf proliferation inhibition EC50 uM>
1.609

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
35.73

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2129
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
   -1.4534   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  4  0  0  0  0
  9 17  4  0  0  0  0
  7 18  4  0  0  0  0
  2 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2129

>  <JC_XSMILES>
CC1=CC=C(C)C(NC2=NC3=C(CCCC3)S2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2130
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 13 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 11 22  4  0  0  0  0
  9 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2130

>  <JC_XSMILES>
COC(=O)C1=CNC=C(C1C2=CC(OC)=C(OC)C(OC)=C2)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
8.99

>  <W2 Pf proliferation inhibition EC50 uM>
4.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2132
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
  6 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
M  CHG  3   2   1  22   1  23  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2132

>  <JC_XSMILES>
C[N+]1=CC(=CC2=CC=CC=C12)C3=CC=C4C=CC=C(C4=N3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.364

>  <W2 Pf proliferation inhibition EC50 uM>
0.45

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2136
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 18 15  1  4  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2136

>  <JC_XSMILES>
CC1=CC=C(C=C1)S(=O)(=O)OC2=CC=C(C=C2)C=NN=C(N)N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1548

>  <W2 Pf proliferation inhibition EC50 uM>
0.631

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.07

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2137
  Mrv1591402191617072D          

 36 38  0  0  0  0            999 V2000
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3427   -4.9455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5357   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1232   -4.4025    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6753   -3.7894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5037   -2.9825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2809   -2.7275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4524   -1.9206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1607   -1.3685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0108   -0.5616    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.9453   -1.6235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1168   -2.4304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2002   -5.8707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1354   -6.6244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5535   -5.5351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9539   -6.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4467   -6.0770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717   -4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 11 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  4 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 30 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
 33 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2137

>  <JC_XSMILES>
CC(C)N(CC(=O)NC1=CC(=NN1C2=CC=C(Cl)C=C2)C(C)(C)C)C(=O)C3=CC=C(C=C3)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
9.96

>  <W2 Pf proliferation inhibition EC50 uM>
4.48

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2138
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1773   -2.3166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7904   -2.8686    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.6253   -2.9297    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.7294   -1.7035    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 17 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2138

>  <JC_XSMILES>
CCCN1CCC(CC1)N2CCCC(C2)C3=C(C=NN3)C4=CC=CC(=C4)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.757

>  <W2 Pf proliferation inhibition EC50 uM>
0.448

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019230769

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-214
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
   -2.6509   -8.4315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9365   -8.0190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2220   -8.4315    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5075   -8.0190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5075   -7.1940    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2070   -8.4315    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9214   -8.0190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9214   -7.1940    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6359   -8.4315    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3504   -8.0190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0648   -8.4315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0648   -9.2565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3504   -9.6690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6359   -9.2565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7793   -9.6690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5330   -9.3335    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0850   -9.9466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6725  -10.6610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8656  -10.4895    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.9055   -9.8603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2411   -9.1067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0615   -9.0204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5465   -9.6879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3669   -9.6016    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2109  -10.4415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3904  -10.5278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6958  -11.1090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1808  -11.7764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0284  -11.5939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3633  -10.6240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3971   -8.2667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7327   -7.5131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1508   -8.6023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6434   -7.9312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
 22 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
 31 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-214

>  <JC_XSMILES>
CCOC(=O)NC(=O)N1CCC(CC1)C2=NC(=CS2)C3=CC(=C(O)C(=C3)C(C)(C)C)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.662

>  <W2 Pf proliferation inhibition EC50 uM>
1.876

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2140
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    2.0626    2.6554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6726    1.9284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8480    1.9027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4580    1.1757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8926    0.4744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5027   -0.2526    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.7172    0.5002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1072    1.2272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9318    1.2530    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3664    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1910    0.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6256   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4502   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8849   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4949   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6703   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2357   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4111   -0.8765    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8784   -1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0751   -2.3078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1147   -1.1947    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1752   -0.3719    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9765   -0.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 10 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2140

>  <JC_XSMILES>
CC1=CC=C(Cl)C=C1NC2=NC3=CC=CC=C3N4C(C)=NN=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.47

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2143
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 14 12  1  4  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 22 29  4  0  0  0  0
  7 29  4  0  0  0  0
 29 30  4  0  0  0  0
  4 30  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2143

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C2NC(=O)C(C(=O)C=CC3=CC=CC=C3)=C(C4=CC=CC=C4)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.37

>  <W2 Pf proliferation inhibition EC50 uM>
>4.46

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2144
  Mrv1591402191617072D          

 15 16  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
  4 14  1  0  0  0  0
 14 15  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2144

>  <JC_XSMILES>
CCSC1=CC(=O)C2=CC=CC=C2C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.551

>  <W2 Pf proliferation inhibition EC50 uM>
0.2304

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.17

>  <Powder data?>
No

>  <IFI value>
0.243243243

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2146
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -1.2370   -1.6656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4086   -0.8586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1932   -0.6037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3647    0.2033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7516    0.7553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9670    0.5004    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7955   -0.3066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0108   -0.5616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6023   -0.0095    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1607   -1.3685    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9453   -1.6235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1168   -2.4304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5037   -2.9825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2809   -2.7275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4524   -1.9206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6753   -3.7894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1232   -4.4025    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5357   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3427   -4.9455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2146

>  <JC_XSMILES>
CC1=CC=CC=C1C(=O)N2CCC(CC2)N3N=CC=C3NC(=O)CCOC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.45

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2148
  Mrv1591402191617072D          

 43 47  0  0  0  0            999 V2000
    8.3550    2.4198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0694    2.0073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0694    1.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7839    0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7839   -0.0552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0694   -0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3550   -0.0552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3550    0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0694   -1.2927    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3550   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6405   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6405   -0.4677    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9260   -1.7052    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2116   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4971   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4971   -2.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7826   -2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0681   -2.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0681   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7826   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3550   -2.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0694   -2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0694   -3.7677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3550   -4.1802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3550   -5.0052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6405   -5.4177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6405   -3.7677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9260   -4.1802    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2116   -3.7677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6405   -2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7839   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7839   -2.5302    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4984   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2128   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9273   -1.2927    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.0136   -0.4722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8205   -0.3007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2330   -1.0152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0400   -1.1867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2949   -1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.7429   -2.5844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9359   -2.4129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6810   -1.6283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 10 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 21 30  4  0  0  0  0
  9 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 35 43  1  0  0  0  0
 38 43  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2148

>  <JC_XSMILES>
CCC1=CC=C(C=C1)N(C(C(=O)NCC2=CC=CC=C2)C3=CC=C(OC)C(OC)=C3)C(=O)CCN4CCC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
5.08

>  <W2 Pf proliferation inhibition EC50 uM>
4.45

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.033333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-215
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.4323    0.3627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0980   -0.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9543   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6194   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 11 20  1  0  0  0  0
  2 20  1  0  0  0  0
 20 21  2  0  0  0  0
  8 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 24 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-215

>  <JC_XSMILES>
CC1(C)OC2=CC=C(C=C2N(CCC3=CC=CC=C3)C1=O)C(=O)N4CCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.119

>  <W2 Pf proliferation inhibition EC50 uM>
1.87

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2153
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -2.1730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -3.6020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
 12  9  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 15 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 13 31  1  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2153

>  <JC_XSMILES>
COC1=CC=C(C=C1)S(=O)(=O)N=C2C=C(NC3=CC=C(O)C=C3)C(=O)C4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1851

>  <W2 Pf proliferation inhibition EC50 uM>
0.1087

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.446

>  <Powder data?>
Yes

>  <IFI value>
0.230769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2154
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256    0.3627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -0.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -4.3257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9908   -5.1657    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4757   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2890   -4.3257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8671   -5.1657    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3822   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 10 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
  8 27  1  0  0  0  0
 27 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 30 35  2  0  0  0  0
 35 36  1  0  0  0  0
 28 36  1  0  0  0  0
 35 37  1  0  0  0  0
 37 38  2  0  0  0  0
 37 39  1  0  0  0  0
 39 40  1  0  0  0  0
M  CHG  2  19   1  20  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2154

>  <JC_XSMILES>
CCOC1=CC=CC2=C1N(C(=O)C3=CC=CC(=C3)[N+]([O-])=O)C(C)(C)C(=S)C2=C4SC(C(=O)OC)=C(S4)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.444

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2155
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6288   -2.9346    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
  9 15  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
  4 19  4  0  0  0  0
 19 20  4  0  0  0  0
  2 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2155

>  <JC_XSMILES>
CC1=NN2C(C)=C(CC3=CC=CC(F)=C3)C(C)=NC2=C1C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.437

>  <W2 Pf proliferation inhibition EC50 uM>
0.444

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2159
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    4.6256    2.6452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8972    3.0325    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4051    3.6826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6423    2.2479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353    2.0763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2833    2.6894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5382    3.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7212    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5094    4.2986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3452    3.6456    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804    1.2917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0653    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804   -0.0432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2875    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6082   -2.1200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0779   -3.0385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -2.6757    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0846   -3.0385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4457   -2.1200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  2 10  1  0  0  0  0
  5 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
 21 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2159

>  <JC_XSMILES>
CC1(C)CC(CC(C)(C)N1)=C2C=CC3C2C4CC3(C=C4)C5=CC(C)(C)NC(C)(C)C5

>  <PF proliferation inhibition 3D7 EC50 uM>
2.232

>  <W2 Pf proliferation inhibition EC50 uM>
1.974

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
44.66

>  <Powder data?>
Yes

>  <IFI value>
0.061538462

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2160
  Mrv1591402191617072D          

 42 46  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 24 32  1  0  0  0  0
 32 33  1  0  0  0  0
 21 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 36 38  1  0  0  0  0
 19 38  1  0  0  0  0
 38 39  1  0  0  0  0
 17 40  4  0  0  0  0
 40 41  4  0  0  0  0
 13 41  4  0  0  0  0
 41 42  4  0  0  0  0
  9 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2160

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=CC(=O)C3=C(O)C=C(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)C=C3O2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.42

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2162
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5921   -2.8329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3371   -3.6175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5121   -3.6175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2572   -2.8329    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
  7 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
  5 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2162

>  <JC_XSMILES>
CN1C=NC2=CC(OC3CCN(CC3)CC4=CC=CO4)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2162

>  <W2 Pf proliferation inhibition EC50 uM>
0.1917

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>4.34

>  <Powder data?>
No

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2163
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -4.4270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -2.9980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7439   -4.5195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5644   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8999   -3.8520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1918   -5.1326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4468   -5.9172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3849   -4.9610    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2163

>  <JC_XSMILES>
CCCCN(CC)S(=O)(=O)C1=CC(Br)=CC2=C1N(CC2)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.561

>  <W2 Pf proliferation inhibition EC50 uM>
0.441

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2167
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    8.3766    5.1457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6316    4.3611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4386    4.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0796    3.7480    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3345    2.9634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7825    2.3503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9755    2.5218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7206    3.3064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2726    3.9195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4235    1.9087    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6784    1.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0645    1.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6165    2.0803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3615    2.8649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5546    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2996    3.8210    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 23 31  1  0  0  0  0
 26 31  4  0  0  0  0
 24 32  4  0  0  0  0
 20 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2167

>  <JC_XSMILES>
CC(C)N1CCC(CC1)N2CCN(CC2CCO)CC3=CC=C4C(CC5=CC=CC=C45)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.543

>  <W2 Pf proliferation inhibition EC50 uM>
0.905

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.54

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2168
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 17 25  4  0  0  0  0
 25 26  4  0  0  0  0
  7 26  4  0  0  0  0
 26 27  4  0  0  0  0
  4 27  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2168

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C2N=C(NC3=CC=CC=C3)C(NC4=CC=CC=C4)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.941

>  <W2 Pf proliferation inhibition EC50 uM>
0.955

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.71

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2172
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    1.1367    3.9719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9594    3.9102    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4241    4.5919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3173    3.1669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1400    3.1053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4980    2.3620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0332    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2105    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8526    2.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3912    0.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2162    0.9370    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7305    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5189    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1237   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9401   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1517   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5470   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8037   -0.8703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0604   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8768    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0884    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9049    1.3395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4837   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6673   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8433   -0.8714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5647   -1.6489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4556   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 10 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 19 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2172

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)C2NC3=CC=CC=C3NC4=C2C(=O)CC(C)(C)C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.39

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.055944056

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2173
  Mrv1591402191617072D          

 47 50  0  0  0  0            999 V2000
   -1.6155    1.4535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3300    1.0410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0444    1.4535    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7589    1.0410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4734    1.4535    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7589    0.2160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4263   -0.2689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2110   -0.0140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1714   -1.0536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6563   -1.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3208   -2.4747    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4768   -1.6348    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8124   -0.8811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6328   -0.7949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3464   -1.0536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8615   -1.7210    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0410   -1.6348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7054   -0.8811    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5561   -2.3022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7356   -2.2160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8916   -3.0559    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4067   -3.7233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6616   -4.5079    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9942   -4.9929    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3268   -4.5079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4579   -4.7629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6294   -5.5698    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4140   -5.8248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0271   -5.2728    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5855   -6.6318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3702   -6.8867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5417   -7.6937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9286   -8.2457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1001   -9.0527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8847   -9.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1440   -7.9908    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9724   -7.1838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5817   -3.7233    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0968   -3.0559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4323   -2.3022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0526   -1.6348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8731   -1.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2086   -2.4747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7237   -3.1421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0593   -3.8958    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8797   -3.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.2689    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 36 37  4  0  0  0  0
 30 37  4  0  0  0  0
 25 38  4  0  0  0  0
 22 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 39 44  4  0  0  0  0
 44 45  1  0  0  0  0
 45 46  1  0  0  0  0
 15 47  4  0  0  0  0
  6 47  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2173

>  <JC_XSMILES>
CCOC(=O)C1=C(C)C(C(=O)OCC)=C(NC(=O)C(C)SC2=NN=C(CNC(=O)C3=CC=C(OC)C=C3)N2C4=CC=CC=C4OC)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.439

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.013513514

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2176
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    5.5970   -4.2185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9295   -3.7336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0158   -2.9131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3483   -2.4282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4346   -1.6077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8215   -1.0556    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -0.4849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4211    0.9744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0886    1.4593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8422    1.1237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5097    1.6087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4234    2.4291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6698    2.7647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0023    2.2798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9775   -0.3882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1491   -1.1952    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 19 28  1  0  0  0  0
 12 28  1  0  0  0  0
 28 29  2  0  0  0  0
  7 30  4  0  0  0  0
 30 31  4  0  0  0  0
  5 31  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  31
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2176

>  <JC_XSMILES>
CCCCC1=NC(CN2CCC3(CC2)N(C)C(=O)N(CCC4=CC=CC=C4)C3=O)=CN1

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.98

>  <W2 Pf proliferation inhibition EC50 uM>
4.38

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.1

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2177
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    3.2789    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2177

>  <JC_XSMILES>
CN1CCN(CC1)C2=NC(Cl)=NC3=C2N=CN3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.174

>  <W2 Pf proliferation inhibition EC50 uM>
0.438

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.006993007

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2178
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   -3.6112   -6.4657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3718   -5.6762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9358   -5.0741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6964   -4.2846    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2604   -3.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0210   -2.8930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2175   -2.7056    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9781   -1.9161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1747   -1.7287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9353   -0.9392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1318   -0.7518    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8924    0.0377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4564    0.6398    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0890    0.2251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1505    1.0146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9539    1.2020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5179    0.5999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3427    0.6162    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0005    1.1142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6774    0.6425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4379   -0.1470    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6131   -0.1633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9554   -0.6613    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2785   -0.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4750   -0.3770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4568    0.9128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6124    1.7230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3918    1.9934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0157    1.4535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7951    1.7239    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9507    2.5341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8601    0.6434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0807    0.3730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6535   -3.3077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8929   -4.0972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 17 24  4  0  0  0  0
 24 25  4  0  0  0  0
 14 25  4  0  0  0  0
 20 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  4  0  0  0  0
 26 33  4  0  0  0  0
  7 34  1  0  0  0  0
 34 35  1  0  0  0  0
  4 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2178

>  <JC_XSMILES>
CCCN1CCN(CCCNC(=O)C2=CC=C3N4C=C(N=C4SC3=C2)C5=CC=C(OC)C=C5)CC1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.437

>  <W2 Pf proliferation inhibition EC50 uM>
4.38

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2179
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 S   0  3  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 12 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  CHG  1  13   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2179

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)C2=CC(=[S+]C(=C2)C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.318

>  <W2 Pf proliferation inhibition EC50 uM>
0.0737

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.687

>  <Powder data?>
Yes

>  <IFI value>
0.314285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-218
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 16 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-218

>  <JC_XSMILES>
COC(=O)C1=CC=CC=C1NC(=O)COC2=CC=CC(OC)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.414

>  <W2 Pf proliferation inhibition EC50 uM>
1.862

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2184
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.0000   -5.7750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 15 20  4  0  0  0  0
  9 21  4  0  0  0  0
  5 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2184

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(NC2=NN=NC3=CC=CC=C23)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.756

>  <W2 Pf proliferation inhibition EC50 uM>
0.433

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.012987013

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2185
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    1.9103   -1.8050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8769   -1.8619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -4.4120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8671   -5.1657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3822   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7177   -6.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2328   -7.2542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5877   -7.1680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9232   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4383   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7739   -4.9932    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
  6 16  1  0  0  0  0
  2 16  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2185

>  <JC_XSMILES>
CC1(C)CN=C(NCC2=CC=CC=C2Cl)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
7.45

>  <W2 Pf proliferation inhibition EC50 uM>
1.481

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
34.22

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2187
  Mrv1591402191617072D          

 15 15  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
M  CHG  2  13   1  14  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2187

>  <JC_XSMILES>
OC(=O)CCNC1=CC=CC=C1[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>8.54

>  <W2 Pf proliferation inhibition EC50 uM>
>4.31

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2188
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  1  0  0  0  0
  6 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 24 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2188

>  <JC_XSMILES>
COC1=CC2=C(NC3=CC=C(Br)C=C3F)N=CN=C2C=C1OCC4CCN(C)CC4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.919

>  <W2 Pf proliferation inhibition EC50 uM>
1.601

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
37.19

>  <Powder data?>
Yes

>  <IFI value>
0.068181818

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2189
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   16.4328   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 13 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2189

>  <JC_XSMILES>
CC(C)CC(=O)NCCCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.62

>  <W2 Pf proliferation inhibition EC50 uM>
0.43

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-219
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -3.1895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.7605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3033   -4.8395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -3.4105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
  9 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  2  0  0  0  0
 27 30  2  0  0  0  0
  6 31  4  0  0  0  0
 31 32  4  0  0  0  0
  3 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-219

>  <JC_XSMILES>
COC1=CC=C(CCN(CC2=CC=C(Cl)C=C2)S(=O)(=O)C3=CC=C(C=C3)S(N)(=O)=O)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
4.72

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
67.33

>  <Powder data?>
Yes

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2192
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -4.6480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -6.0770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.0125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2192

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)S(=O)(=O)C3=CC=C(Br)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1858

>  <W2 Pf proliferation inhibition EC50 uM>
0.2954

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.88

>  <Powder data?>
No

>  <IFI value>
0.074074074

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2195
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5253    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2704    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4454    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1904    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
 11 22  4  0  0  0  0
 22 23  4  0  0  0  0
  8 23  4  0  0  0  0
  2 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2195

>  <JC_XSMILES>
CN(CC(O)COC1=CC=C(CNCCCN2CCCC2)C=C1)CC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.377

>  <W2 Pf proliferation inhibition EC50 uM>
2.561

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
59.78

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2198
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  8 21  4  0  0  0  0
 21 22  4  0  0  0  0
  4 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2198

>  <JC_XSMILES>
CCOC1=C(Cl)C=C(CNC(C)C(O)C2=CC=CC=C2)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.654

>  <W2 Pf proliferation inhibition EC50 uM>
0.427

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2200
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    9.0681    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    4.8229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    4.8229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 16 26  4  0  0  0  0
 26 27  2  0  0  0  0
 23 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 10 34  4  0  0  0  0
  6 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2200

>  <JC_XSMILES>
CCOC(=O)C1=CC=CC(NC(=O)CCN2N=C(C)C3=C(C)N(N=C3C2=O)C4=CC=CC=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
3.064

>  <W2 Pf proliferation inhibition EC50 uM>
4.27

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2202
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2202

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC=CC(F)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.739

>  <W2 Pf proliferation inhibition EC50 uM>
0.49

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.51

>  <Powder data?>
No

>  <IFI value>
0.037735849

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2207
  Mrv1591402191617072D          

 27 31  0  0  0  0            999 V2000
    5.5986    2.3502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8148    2.6077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6458    3.4152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8620    3.6726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2472    3.1225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4633    3.3799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4161    2.3150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8013    1.7649    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9703    0.9574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7541    0.7000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4698    1.1102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0812    0.5562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7432   -0.1964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9230   -0.1075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3082   -0.6576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4772   -1.4651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6461   -2.2727    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5244   -0.4002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8086   -0.8104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1973   -0.2565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3765   -0.3401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1063    0.3289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2317    1.0815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0524    1.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5352    0.4961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3554    0.4073    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1999    2.0576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  3  0  0  0  0
 15 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
  9 26  4  0  0  0  0
 18 26  4  0  0  0  0
  7 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2207

>  <JC_XSMILES>
CC1=CC=C(O)C(NC2=C3CCCC3=C(C#N)C4=NC5=CC=CC=C5N24)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2311

>  <W2 Pf proliferation inhibition EC50 uM>
0.424

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2208
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  7  6  1  4  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  6 15  4  0  0  0  0
  2 15  4  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2208

>  <JC_XSMILES>
OC1=CC=CC(C=NC2=CC=CC=C2)=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.36

>  <W2 Pf proliferation inhibition EC50 uM>
0.435

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.28

>  <Powder data?>
No

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-221
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 12 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
  9 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 33 34  1  0  0  0  0
  7 35  4  0  0  0  0
 35 36  4  0  0  0  0
  4 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-221

>  <JC_XSMILES>
CCOC1=CC=C(CN(CCC(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4C)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.351

>  <W2 Pf proliferation inhibition EC50 uM>
1.85

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009259259

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2212
  Mrv1591402191617072D          

 30 31  0  0  0  0            999 V2000
   -2.1238   -3.2472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3168   -3.0756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7648   -3.6887    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0619   -2.2910    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2549   -2.1195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2549    0.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0619    0.9561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3168    1.7408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7648    2.3539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1238    1.9123    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -0.6674    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8242    0.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2721    1.3977    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5271    2.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9751    2.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3341    2.3539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8792   -0.6674    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -1.3349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8242   -2.1195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2721   -2.7326    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5271   -3.5172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3341   -3.6887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9751   -4.1303    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
  9 15  1  0  0  0  0
  6 15  1  0  0  0  0
 15 16  2  0  0  0  0
  8 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 17 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
  7 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2212

>  <JC_XSMILES>
CC(=O)OCN1C2C(N(COC(C)=O)C1=O)N(COC(C)=O)C(=O)N2COC(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.6

>  <W2 Pf proliferation inhibition EC50 uM>
4.22

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011363636

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2213
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    3.6018   -3.0331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4712   -0.6979    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.1271    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -1.5229    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  1  0  0  0  0
 13 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
  7 29  4  0  0  0  0
  2 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2213

>  <JC_XSMILES>
CC1=CC=C(C)C(NC2=C(C(=O)C3=CC=CC=C23)C4=CC=C(C=C4)C(F)(F)F)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.848

>  <W2 Pf proliferation inhibition EC50 uM>
4.22

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2214
  Mrv1591402191617072D          

 33 37  0  0  1  0            999 V2000
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 17  2  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 18 26  1  0  0  0  0
 26 27  2  0  0  0  0
 17 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2214

>  <JC_XSMILES>
O=C(NC1CCN(CC1)CC2=CC=CC=C2)[C@H](N3CC4=CC=CC=C4C3=O)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.21

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2215
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919    3.2065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8370    3.9911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0524    4.2461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0524    5.0711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8370    5.3260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919    6.1106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3219    4.6586    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6018    1.6373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1538    2.2503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9608    2.0788    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 13 18  4  0  0  0  0
 11 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 19 23  1  0  0  0  0
  8 23  1  0  0  0  0
  6 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
  4 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2215

>  <JC_XSMILES>
CC(C)N1C=C(CN2CCN(CC3=CC=C(C)O3)C(CCO)C2)C4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.21

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2217
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  2  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 15 25  1  0  0  0  0
 25 26  1  0  0  0  0
 12 26  1  0  0  0  0
 10 27  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2217

>  <JC_XSMILES>
ClC1=CC=C2OC(=O)C=C(NC3CCN(CCCC4=CC=CC=C4)CC3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.408

>  <W2 Pf proliferation inhibition EC50 uM>
0.863

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.52

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2218
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 13 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 11 24  4  0  0  0  0
 24 25  2  0  0  0  0
  9 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 29 35  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  23
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2218

>  <JC_XSMILES>
CCN(CC)CCCN(CC1=CC2=CC3=C(OCCO3)C=C2NC1=O)C(=S)NC4=CC=CC(Cl)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.164

>  <W2 Pf proliferation inhibition EC50 uM>
0.89

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.21

>  <Powder data?>
Yes

>  <IFI value>
0.068965517

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-222
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    4.2135   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6816    2.2710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2336    1.6579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8211    0.9434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0142    1.1150    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
  6 25  4  0  0  0  0
  2 25  4  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-222

>  <JC_XSMILES>
CC1=CC=CC(NC2=NC3=NON=C3NC2=NN=CC4=CC=CS4)=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
8.65

>  <W2 Pf proliferation inhibition EC50 uM>
4.3

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.29

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2220
  Mrv1591402191617072D          

 30 29  0  0  0  0            999 V2000
   13.4211    8.5737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1355    8.9862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.8500    8.5737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.5645    8.9862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.2789    8.5737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.9934    8.9862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.7079    8.5737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.4224    8.9862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.1368    8.5737    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   19.8513    8.9862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.8513    9.8112    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   20.5658    8.5737    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   21.2802    8.9862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.9947    8.5737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.7092    8.9862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   23.4237    8.5737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   24.1381    8.9862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   24.8526    8.5737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   25.5671    8.9862    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   26.2815    8.5737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   26.2815    7.7487    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   26.9960    8.9862    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   27.7105    8.5737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   28.4249    8.9862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   29.1394    8.5737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   29.8539    8.9862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   30.5684    8.5737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   31.2828    8.9862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   31.9973    8.5737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   32.7118    8.9862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2220

>  <JC_XSMILES>
CCCCCCCCOC(=O)NCCCCCCNC(=O)OCCCCCCCC

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.19

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2222
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    5.0013   -2.8875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.8908   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5408   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2222

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2N\C=C\C(=O)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.419

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.011764706

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2224
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6561    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4407    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4407    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6561    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  2  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  7 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 12 21  4  0  0  0  0
  4 21  4  0  0  0  0
 21 22  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2224

>  <JC_XSMILES>
CCCN1C(=O)N(CCC)C2=C(N=C(N2)C3CCCC3)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.764

>  <W2 Pf proliferation inhibition EC50 uM>
0.346

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.26

>  <Powder data?>
No

>  <IFI value>
0.014084507

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2226
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  8 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2226

>  <JC_XSMILES>
CCN(CC)C1=CC(=NC(=N1)C2=CC=CC=N2)C3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.578

>  <W2 Pf proliferation inhibition EC50 uM>
0.418

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2227
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    2.8579   -3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2227

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(=C1)C2=CN=CC(=N2)N3CCN(CC3)C4=CC=CC=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
5.77

>  <W2 Pf proliferation inhibition EC50 uM>
1.909

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
45.71

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2228
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -2.0367    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    0.7634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6548   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1298   -2.7666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9097   -3.8062    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7347   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2197   -4.4736    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8841   -5.2273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0636   -5.3135    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3690   -5.8947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0335   -6.6484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2130   -6.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8774   -7.4883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3624   -8.1557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1828   -8.0695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6678   -8.7369    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3322   -9.4906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5184   -7.3158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9897   -3.0215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
 19 26  4  0  0  0  0
 14 27  4  0  0  0  0
 10 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2228

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)C2=C(C)SC(NC(=O)CC3=CC=CC(OC)=C3)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2727

>  <W2 Pf proliferation inhibition EC50 uM>
0.417

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.032258065

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-223
  Mrv1591402191617072D          

 35 37  0  0  0  0            999 V2000
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3260    0.9019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8781    1.5150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4656    2.2295    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6586    2.0580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 12 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 10 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
  6 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-223

>  <JC_XSMILES>
COC1=CC=C(CCNC2=NC(NCCCN3C=CN=C3)=NC=C2C(=O)NCC(C)C)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.563

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.78

>  <Powder data?>
No

>  <IFI value>
0.019230769

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2230
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 18 28  4  0  0  0  0
 23 28  4  0  0  0  0
 16 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 13 31  4  0  0  0  0
 11 32  4  0  0  0  0
  6 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2230

>  <JC_XSMILES>
COC1=CC=C2N=C(C)C=C(NC3=CC=C(OC4=CC=C(Cl)C5=CC=CC=C45)C(Cl)=C3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.365

>  <W2 Pf proliferation inhibition EC50 uM>
0.826

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.81

>  <Powder data?>
Yes

>  <IFI value>
0.101123596

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2232
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  7 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 13 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
 25 32  1  0  0  0  0
 12 32  1  0  0  0  0
 32 33  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2232

>  <JC_XSMILES>
CCOC1=CC=C(C=C1OC)C2N(CC3=CC=C(F)C=C3)C(=O)CN(C4CCCCC4)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
4.56

>  <W2 Pf proliferation inhibition EC50 uM>
4.15

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2233
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.0000    3.3000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2233

>  <JC_XSMILES>
BrC1=CC=C(NC2=NC3=CC=CC=C3N=C2NC4=CC=C(Br)C=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.809

>  <W2 Pf proliferation inhibition EC50 uM>
0.854

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.59

>  <Powder data?>
Yes

>  <IFI value>
0.141791045

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2234
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 10 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  3  0  0  0  0
 17 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 20 35  4  0  0  0  0
  8 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2234

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=CC(C3=CC=CC=C3)=C(C#N)C(SCC(O)CS(=O)CC4=CC=CC=C4)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
7.17

>  <W2 Pf proliferation inhibition EC50 uM>
1.65

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
39.93

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2236
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    4.4782   -4.0537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7482   -3.2741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5583   -3.1182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0984   -3.7418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9086   -3.5859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1786   -2.8064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6385   -2.1827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8284   -2.3387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9086   -1.4032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7187   -1.2473    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3685   -0.7796    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5583   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0182   -0.3118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2081   -0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6680    0.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9381    0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3178    0.6236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5077    0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9676    1.0914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1574    0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1126    0.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2376    1.8709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0477    2.0268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3178    2.8064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1279    2.9623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6680    2.3387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3980    1.5591    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5878    1.4032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6385    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4486    0.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7187    0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5288    1.0914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0689    0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8790    0.6236    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.7989   -0.3118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9887   -0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 18 29  4  0  0  0  0
 24 29  4  0  0  0  0
 11 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 31 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2236

>  <JC_XSMILES>
COC1=CC=CC(=C1)C(=O)N(CCCC(C)NC2=CC(OC)=CC3=CC=CN=C23)CC4=CC=C(F)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.666

>  <W2 Pf proliferation inhibition EC50 uM>
0.1539

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.73

>  <Powder data?>
No

>  <IFI value>
0.028037383

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2238
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -3.1034   -3.5558    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -2.1269    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 10 23  4  0  0  0  0
  7 23  4  0  0  0  0
  5 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2238

>  <JC_XSMILES>
FC1=CC=C(CC2=NC3=C(CN(CC3)C(=O)C4=CC=CC=C4)S2)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.4

>  <W2 Pf proliferation inhibition EC50 uM>
2.358

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>57.37

>  <Powder data?>
Yes

>  <IFI value>
0.013888889

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-224
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-224

>  <JC_XSMILES>
OC1=CC=CC=C1C(=O)OCC(=O)C2=CC=C(Br)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.539

>  <W2 Pf proliferation inhibition EC50 uM>
1.823

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.046511628

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2240
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    3.4656    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4888   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -3.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1661   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1694   -4.5710    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.9866   -3.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -2.9774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8372   -2.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0168   -2.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4682   -1.7287    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1426   -2.8911    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9631   -2.8049    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0564   -2.0707    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2289   -3.7116    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  2  0  0  0  0
 10 24  4  0  0  0  0
  6 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2240

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N=C(NC2=C(Cl)C=C(C=C2Cl)S(N)(=O)=O)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.411

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2243
  Mrv1591402191617072D          

 14 15  0  0  0  0            999 V2000
    4.7812    4.4104    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  4  0  0  0  0
 13 14  4  0  0  0  0
  6 14  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2243

>  <JC_XSMILES>
ClCC(=O)NC1=CC=C2OCOC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.903

>  <W2 Pf proliferation inhibition EC50 uM>
0.831

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.29

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2244
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
  7 23  4  0  0  0  0
  5 24  4  0  0  0  0
 24 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2244

>  <JC_XSMILES>
CC1=CC=C(NC2=NC(NCC3=CC=CO3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.126

>  <W2 Pf proliferation inhibition EC50 uM>
0.2156

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.27

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2245
  Mrv1591402191617072D          

 32 34  0  0  1  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4647   -4.0640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0778   -4.6160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8624   -4.3611    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.0339   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4755   -4.9131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2601   -4.6582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3040   -5.7201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -4.3257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4824   -3.5721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6318   -4.9932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4522   -4.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9372   -5.5744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6016   -6.3281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0865   -6.9955    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9070   -6.9093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7811   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2962   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4757   -5.8331    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9908   -5.1657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  5  3  1  6  0  0  0
  5  6  1  0  0  0  0
  7  6  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 14 13  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  1  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
  7 20  1  1  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 26 29  4  0  0  0  0
 29 30  4  0  0  0  0
 23 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2245

>  <JC_XSMILES>
COC(=O)[C@@H]1C[C@H](CN1CC2=CC[C@H](CC2)C(C)=C)NC(=O)C3=CC=C(OC)C=C3OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.815

>  <W2 Pf proliferation inhibition EC50 uM>
0.409

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017391304

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2246
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    1.3222    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    4.7652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186    1.8053    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637    1.0206    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387    1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837    1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8538    0.3532    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0333    0.4394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5484   -0.2280    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8839   -0.9817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3990   -1.6491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6539   -2.4337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0135   -2.9187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6810   -2.4337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4260   -1.6491    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6977    1.1931    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1228    1.2793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 14 12  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 15 23  1  0  0  0  0
 23 24  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  11
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2246

>  <JC_XSMILES>
COC1=CC=CC(=C1)C2=NNC(=C2)N=C(NCC3=CC=CO3)SC

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.34

>  <W2 Pf proliferation inhibition EC50 uM>
2.872

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
70.43

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2247
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
   -3.8837   -1.4124    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
  5 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2247

>  <JC_XSMILES>
IC1=CC=C(NCC2=CN3C=CC=CC3=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
6.37

>  <W2 Pf proliferation inhibition EC50 uM>
4.07

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.082089552

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2249
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6144   -5.0895    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2788   -5.8432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6913   -6.5577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5163   -6.5577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9288   -5.8432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7538   -5.8432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1663   -6.5577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7538   -7.2721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9288   -7.2721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4584   -5.7570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9063   -6.3701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 18 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
  8 28  4  0  0  0  0
 16 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2249

>  <JC_XSMILES>
CCOC(=O)CSC1=NC2=CC=CC=C2C3=NC(CC4=CC=CC=C4)C(=O)N13

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.407

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.036144578

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-225
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9849   -2.1730    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599   -3.6020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 16 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-225

>  <JC_XSMILES>
COC1=CC=CC(OC)=C1C(=O)NC2=CC(=CC=C2Cl)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.814

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.014492754

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2251
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5429    2.0445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2775    2.1307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6131    1.3770    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  2  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
  7 11  4  0  0  0  0
 11 12  4  0  0  0  0
  3 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
 24 25  4  0  0  0  0
 18 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2251

>  <JC_XSMILES>
CCN1C(=O)C2=C(C=CS2)N=C1SCC(=O)NC3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.475

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.7

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2255
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -3.5159   -2.8414    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3890   -2.5394    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8179   -1.7144    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8708    0.9475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6777    1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0902    0.4046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5382   -0.2085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  1  0  0  0  0
 14 24  4  0  0  0  0
 11 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2255

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(=C1)C2=NC3=C(CN(CC3)C4CCCC4)S2

>  <PF proliferation inhibition 3D7 EC50 uM>
5.37

>  <W2 Pf proliferation inhibition EC50 uM>
2.953

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
73.02

>  <Powder data?>
Yes

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2257
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    3.5724    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8984    1.9856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4504    1.3725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0379    0.6580    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2309    0.8295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
  5 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 18 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2257

>  <JC_XSMILES>
OC1=CC=C(C=C1CNCCCN2C=CN=C2)C3=CC=NC4=CC(Cl)=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1666

>  <W2 Pf proliferation inhibition EC50 uM>
0.403

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.043103448

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2258
  Mrv1591402191617072D          

 37 39  0  0  0  0            999 V2000
    1.4708   -6.2568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2634   -6.0280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6597   -7.4008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8671   -7.6297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6505   -6.3712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2450   -6.9432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0376   -6.7144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6321   -7.2864    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4247   -7.0576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6229   -6.2568    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.0192   -7.6297    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8118   -7.4008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0100   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8026   -6.3712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0008   -5.5703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7934   -5.3415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3879   -5.9136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1898   -6.7144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7842   -7.2864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3971   -6.9432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8211   -8.4305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4155   -9.0025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2082   -8.7737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8026   -9.3458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5953   -9.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1898   -9.6890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9824   -9.4602    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.5769  -10.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9916  -10.4898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5861  -11.0619    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.3787  -10.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1990  -10.7186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6045  -10.1466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8118  -10.3754    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2174   -9.8034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4247  -10.0322    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 15 21  4  0  0  0  0
 12 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  4  0  0  0  0
 25 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 23 36  4  0  0  0  0
 36 37  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  35
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2258

>  <JC_XSMILES>
CCN(CC)CCCNC(=S)N(CCC1=CC=CC(C)=C1)CC2=CC3=CC(OC)=C(OC)C=C3NC2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.433

>  <W2 Pf proliferation inhibition EC50 uM>
0.747

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.6

>  <Powder data?>
Yes

>  <IFI value>
0.114285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2259
  Mrv1591402191617072D          

 31 32  0  0  0  0            999 V2000
   -3.4936   -1.1725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2236   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4135   -2.1079    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6835   -3.5111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8734   -1.4843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.7048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6033   -0.0811    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8734    0.6984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6835    0.8543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2236    0.2307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0337    0.3866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5738   -0.2370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3839   -0.0811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9240   -0.7048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7342   -0.5488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6540    0.6984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1139    1.3221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3038    1.1662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7637    1.7898    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9535    1.6339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4135    2.2575    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7932   -0.2370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2531    0.3866    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5231   -1.0166    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2870   -1.1725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5570   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3672   -2.1079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6372   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4473   -3.0434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0971   -3.5111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 12 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 10 21  4  0  0  0  0
 21 22  2  0  0  0  0
  8 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2259

>  <JC_XSMILES>
CCN(CC)CCN(CC1=CC2=CC(CC)=CC=C2NC1=O)C(=S)NCCCN(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
2.274

>  <W2 Pf proliferation inhibition EC50 uM>
1.533

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
38.18

>  <Powder data?>
Yes

>  <IFI value>
0.053571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-226
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
  4 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  2  0  0  0  0
 15 21  1  0  0  0  0
  2 21  1  0  0  0  0
  3 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  CHG  2  11   1  12  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-226

>  <JC_XSMILES>
CC1=C(C(C2=CC=CC(=C2)[N+]([O-])=O)C3=C(CCCC3=O)N1)C(=O)OCCOC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.81

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2260
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  4 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
  2 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2260

>  <JC_XSMILES>
CC1CC2(C)OC3=CC=CC=C3CC2C(C)C1CNCCCN(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2408

>  <W2 Pf proliferation inhibition EC50 uM>
0.1922

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.79

>  <Powder data?>
Yes

>  <IFI value>
0.092307692

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2264
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -3.3565    0.3443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9440   -0.3702    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1190   -0.3702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7065   -1.0846    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7065    0.3443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0420    1.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8490    1.2695    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1039    2.0541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5519    2.6672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9109    2.2256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2465    2.9793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0670    2.8931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2385    2.0861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9922    1.7506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5240    1.6736    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8860    0.4305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 10 15  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 19 27  4  0  0  0  0
 27 28  4  0  0  0  0
 16 28  4  0  0  0  0
 28 29  4  0  0  0  0
  5 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2264

>  <JC_XSMILES>
COC(=O)C1=C(NC(=O)C2=CC=C(C)S2)C3=CC=C(CN(C)CC(C)C)N=C3S1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.01

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.009615385

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2265
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
   -2.2216    0.2288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8345    0.5720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0418    0.3432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5526    0.9153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3453    0.6864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9398    1.2585    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7416    2.0593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3361    2.6314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1287    2.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9490    2.2881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3545    1.7161    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4381    1.9449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0326    1.3729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8253    1.6017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0234    2.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.9746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6363    2.7458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0418    3.3178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2400    4.1186    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7508    3.0890    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3453    3.6610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1471    4.4619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7416    5.0339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5342    4.8051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7324    4.0042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5250    3.7754    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1379    3.4322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7324    1.0297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3269    1.6017    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9305    0.2288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7232    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9213   -0.8008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7140   -1.0297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9121   -1.8305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3177   -2.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5250   -2.1737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3269   -1.3729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 22 28  4  0  0  0  0
  7 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2265

>  <JC_XSMILES>
CCCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC(Cl)=C3)C(=O)COC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.737

>  <W2 Pf proliferation inhibition EC50 uM>
4.01

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2268
  Mrv1591402191617072D          

 35 40  0  0  0  0            999 V2000
    0.1190   -4.5039    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    5.0771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 10 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  8 22  4  0  0  0  0
 17 22  4  0  0  0  0
 18 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2268

>  <JC_XSMILES>
ClC1=CC=C(C=C1)N2C=C(C3=CC=CC=C3)C4=C(N=CN=C24)N5CCC(CC5)CC6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
>10

>  <W2 Pf proliferation inhibition EC50 uM>
>3.99

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2269
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.4271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.6021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    0.5396    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
 15 24  4  0  0  0  0
 14 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  3  0  0  0  0
 25 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 13 31  4  0  0  0  0
 31 32  4  0  0  0  0
 10 32  4  0  0  0  0
  6 33  4  0  0  0  0
 33 34  4  0  0  0  0
  3 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2269

>  <JC_XSMILES>
CCC1=CC=C(NC(=O)C2=C(N)C3=C(C4=CC=C(OC)C(OC)=C4)C(C#N)=C(N)N=C3S2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
5.81

>  <W2 Pf proliferation inhibition EC50 uM>
3.99

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.010638298

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-227
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -8.2500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -8.2500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  2  0  0  0  0
 27 29  4  0  0  0  0
 18 29  4  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-227

>  <JC_XSMILES>
CCCCC(CC)C(=O)N1CCN(CC1)C(C)C2=NC3=CC=C(Cl)C=C3C(=O)N2C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.487

>  <W2 Pf proliferation inhibition EC50 uM>
1.808

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2270
  Mrv1591402191617072D          

 29 30  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 15 21  4  0  0  0  0
 21 22  1  0  0  0  0
  9 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 29  4  0  0  0  0
  6 29  4  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2270

>  <JC_XSMILES>
CCCCCC1=CC=C(OCCCC[N+]2=CC=CC(C)=C2C)C(CCCCC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2152

>  <W2 Pf proliferation inhibition EC50 uM>
0.1196

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.004

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2271
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    5.6645    0.8546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2520    0.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270    0.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145   -0.5743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895   -0.5743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    0.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    0.1401    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.8546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.8546    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    2.9980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    4.4270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    2.2836    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270    4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2520    4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6645    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2520    2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270    2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270    1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    0.8546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    0.8546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  2  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 10 27  4  0  0  0  0
 27 28  4  0  0  0  0
  6 28  4  0  0  0  0
 28 29  4  0  0  0  0
  3 29  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   7
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2271

>  <JC_XSMILES>
CCC1=CC=C2NC(=O)C(CN(CCO)C(=S)NC3=CC=CC=C3CC)=CC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.618

>  <W2 Pf proliferation inhibition EC50 uM>
1.913

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.05

>  <Powder data?>
Yes

>  <IFI value>
0.064814815

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2272
  Mrv1591402191617072D          

 15 16  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  2  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  2  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  2 15  4  0  0  0  0
  7 15  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2272

>  <JC_XSMILES>
CN1N=C(C)N=C2C(=O)N(C)C(=O)N=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.593

>  <W2 Pf proliferation inhibition EC50 uM>
0.398

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.25

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2273
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4793   -0.5874    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6543    0.8415    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    0.5396    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.3646    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    3.0146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0681    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7825    0.9521    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.6556    0.6501    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.4806    2.0790    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  5 13  1  0  0  0  0
  8 13  4  0  0  0  0
 10 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2273

>  <JC_XSMILES>
CCC(=O)N1CCC2=CC(=CC=C12)S(=O)(=O)N3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.574

>  <W2 Pf proliferation inhibition EC50 uM>
0.398

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.057142857

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2274
  Mrv1591402191617072D          

 21 25  0  0  0  0            999 V2000
    6.4862    0.5346    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.6614    0.5164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2648   -0.2070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4400   -0.2253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0118    0.4799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4084    1.2033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2332    1.2216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1870    0.4617    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6875    1.1183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9250    1.9083    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8280    0.7618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1853    1.2427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4801    0.8145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4983   -0.0103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2217   -0.4069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8462   -0.0630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7170   -0.2163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9892   -0.9951    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4097    0.4224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1149    0.8506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1331    0.0258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  2  0  0  0  0
 15 19  1  0  0  0  0
 12 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2274

>  <JC_XSMILES>
BrC1=CC=C(C=C1)N2C(=O)C3C4C=CC(C3C2=O)C45CC5

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.98

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2275
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
   -5.6442   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8192   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4067   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5817   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1692   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5817   -3.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4067   -3.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8192   -4.0789    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -5.6442   -4.0789    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -4.4067   -4.7933    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3442   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9317   -3.3644    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9317   -1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1067   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5433   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
  5 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 22 31  4  0  0  0  0
 31 32  4  0  0  0  0
 20 32  4  0  0  0  0
M  CHG  2   8   1   9  -1
M  STY  1   1 DAT
M  SAL   1  1  32
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2275

>  <JC_XSMILES>
CC1=CC=C(C=C1[N+]([O-])=O)C(=O)NC2=CC=C(C=C2)C3=NC4=CC5=CC=CC=C5C=C4N3

>  <PF proliferation inhibition 3D7 EC50 uM>
4.3

>  <W2 Pf proliferation inhibition EC50 uM>
3.98

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.090909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2278
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
   -2.7541    0.6198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2021    0.0067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8152   -0.5453    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5890    0.5587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6501   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9050   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3530   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5460   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1215   -2.3175    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7889   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5340   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0860   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8930   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1479   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5959   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8508   -2.7887    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6578   -2.9602    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2910   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8431   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  4  0  0  0
 11 18  4  0  0  0  0
  8 18  4  0  0  0  0
 18 19  4  0  0  0  0
  5 19  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   9
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2278

>  <JC_XSMILES>
CC(C)(C)C1=CC=C2NC3=C(CCCC3=NO)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
5.02

>  <W2 Pf proliferation inhibition EC50 uM>
0.831

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.93

>  <Powder data?>
Yes

>  <IFI value>
0.031746032

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2283
  Mrv1591402191617072D          

 52 60  0  0  0  0            999 V2000
   -3.2160   -4.5838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9610   -3.7992    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1541   -3.6277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8991   -2.8431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0921   -2.6715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5401   -3.2846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7951   -4.0692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6020   -4.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2669   -3.1131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6024   -2.3594    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4229   -2.4457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5944   -3.2526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8799   -3.6651    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3481   -3.5882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0155   -3.1033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7692   -3.4388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8554   -4.2593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1880   -4.7442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4343   -4.4087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464    0.7035    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0700   -2.4457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8904   -2.3594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2260   -3.1131    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6129   -3.6651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8984   -3.2526    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6991   -4.4856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4528   -4.8212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5391   -5.6417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8716   -6.1266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9579   -6.9471    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7115   -7.2826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1179   -5.7910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0317   -4.9705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3029   -1.6450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8904   -0.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3029   -0.2160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1279   -0.2160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5404   -0.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1279   -1.6450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 11 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  1  0  0  0  0
 23 32  4  0  0  0  0
 32 33  4  0  0  0  0
 20 33  4  0  0  0  0
 29 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 34 38  4  0  0  0  0
 37 39  1  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  1  0  0  0  0
 43 44  1  0  0  0  0
 42 45  4  0  0  0  0
 45 46  4  0  0  0  0
 39 46  4  0  0  0  0
 35 47  1  0  0  0  0
 47 48  4  0  0  0  0
 48 49  4  0  0  0  0
 49 50  4  0  0  0  0
 50 51  4  0  0  0  0
 51 52  4  0  0  0  0
 47 52  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  13
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  38
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2283

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=CC=C3)C4=CC=C5C(=O)C6=CC=C(C=C6C5=C4)C7=C(N=C(N7)C8=CC=C(OC)C=C8)C9=CC=CC=C9

>  <PF proliferation inhibition 3D7 EC50 uM>
7.3

>  <W2 Pf proliferation inhibition EC50 uM>
3.75

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
94.5

>  <Powder data?>
Yes

>  <IFI value>
0.015384615

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2285
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -4.1974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -4.9820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -5.6495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -5.6495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -5.5632    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -6.2307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -6.9844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -7.0706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -6.4032    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -7.6518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8871   -7.5656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3721   -8.2330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0365   -8.9867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2160   -9.0729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7311   -8.4055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5214   -9.6541    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.3419   -9.5679    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.1859  -10.4078    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  2  7  4  0  0  0  0
  4  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2285

>  <JC_XSMILES>
CC1=NN(C(C)=C1)C2=NC=C(C=N2)C3=CC=C(C=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.96

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2286
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
   -2.2673    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -2.3215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2673   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8194   -2.6646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5644   -1.8800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7575   -1.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -4.8229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -6.4729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
  8 17  4  0  0  0  0
 17 18  4  0  0  0  0
  6 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 28 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 31 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2286

>  <JC_XSMILES>
CC(C)CCN1N=C(C(=O)N2CCOCC2)C3=C1CCN(C3)C(=O)C4=CC=C(C=C4)N5CCOCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.81

>  <W2 Pf proliferation inhibition EC50 uM>
3.96

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.025641026

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2288
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5700    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
  5 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 13 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 12 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2288

>  <JC_XSMILES>
CC(=O)N(C1=CC=CC(Cl)=C1)C2=C(N3CCOCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2139

>  <W2 Pf proliferation inhibition EC50 uM>
0.1866

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.72

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2289
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    1.3222   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -2.9491    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -4.2590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -5.0437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -5.0437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -4.2590    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -5.7111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4748   -6.4648    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -5.6249    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1661   -6.2923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9866   -6.2061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -5.4524    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8372   -4.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0168   -4.8712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1426   -5.3661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6276   -6.0336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4480   -5.9473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7836   -5.1937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2987   -4.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4782   -4.6125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2289

>  <JC_XSMILES>
CC1=CC=CC=C1S(=O)CC2=CC=C(O2)C(=O)N3CCN(CC3)C4=CC=CC=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
>7.13

>  <W2 Pf proliferation inhibition EC50 uM>
1.659

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>41.98

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2293
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1842    1.8695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2448    1.8695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  4  0  0  0  0
 11 12  4  0  0  0  0
  5 12  4  0  0  0  0
  3 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 13 21  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2293

>  <JC_XSMILES>
CCC(NC1=CC=C(OC)C=C1)=C2C(=O)CC(C)(C)CC2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>4.14

>  <W2 Pf proliferation inhibition EC50 uM>
3.95

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2297
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -1.4289   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  1  0  0  0  0
  5 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2297

>  <JC_XSMILES>
ClC1=CC=C(NC(=O)NNC2=NC3=CC=CC=C3N=C2Cl)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2184

>  <W2 Pf proliferation inhibition EC50 uM>
0.3059

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.76

>  <Powder data?>
Yes

>  <IFI value>
0.024

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2298
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  3 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 11 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
  2 25  1  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2298

>  <JC_XSMILES>
O=C1C(NC2=CC=CC=C2)=C(N3CCCCC3)C(=O)C4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
0.383

>  <W2 Pf proliferation inhibition EC50 uM>
0.59

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.97

>  <Powder data?>
Yes

>  <IFI value>
0.108108108

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2299
  Mrv1591402191617072D          

 36 41  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  2 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 21 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2299

>  <JC_XSMILES>
C1C([CH+]C(OC1C2=CC=CC=C2)C3=CC=CC=C3)C4CC(OC([CH+]4)C5=CC=CC=C5)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
1.243

>  <W2 Pf proliferation inhibition EC50 uM>
0.394

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.133333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-230
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   -1.1633    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2673    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 16 27  4  0  0  0  0
 27 28  4  0  0  0  0
 13 28  4  0  0  0  0
 28 29  2  0  0  0  0
 27 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-230

>  <JC_XSMILES>
CC1=CC=C(C=C1C)N2C(=S)SC3=C2N=C(SCC(=O)C4=CC=CC=C4)N(C3=O)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.793

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2300
  Mrv1591402191617072D          

 42 47  0  0  0  0            999 V2000
   -2.4225   -4.4860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8177   -3.9249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2565   -4.5296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3788   -3.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2129   -3.3637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3965   -2.5594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7917   -1.9983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0034   -2.2414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1802   -3.0457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4246   -3.6069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6014   -1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4178   -0.8760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0226   -0.3148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8390    0.4895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8109   -0.5580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3253    0.0870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1503    0.0870    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5083    0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0435    1.5120    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3309    0.8920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7957    0.2103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6184    0.2720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9763    1.0153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5116    1.6969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6889    1.6353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2242    2.3169    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.6647   -0.5580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4530   -0.3148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0578   -0.8760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8742   -1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0859   -1.9235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4811   -1.3623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7378   -1.7203    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9945   -1.3623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3897   -1.9235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9673    0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1447    0.8920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7867    1.6353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2514    2.3169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8935    3.0602    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.0741    2.2553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4321    1.5120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 17 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  2  0  0  0  0
 15 34  1  0  0  0  0
 34 35  1  0  0  0  0
 11 35  1  0  0  0  0
 16 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  1  0  0  0  0
 39 41  4  0  0  0  0
 41 42  4  0  0  0  0
 36 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2300

>  <JC_XSMILES>
CC(C)(C)C1=CC=C(C=C1)C2CC(O)=C3C(N(C(=O)C4=CC=CC=C4Cl)C5=CC=CC=C5N=C3C2)C6=CC=C(F)C=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
2.63

>  <W2 Pf proliferation inhibition EC50 uM>
3.94

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2301
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  1  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 12 20  4  0  0  0  0
  8 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2301

>  <JC_XSMILES>
N(C1=CC=CC=C1)C2=CC=NC(NC3=CC=CC=C3)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.804

>  <W2 Pf proliferation inhibition EC50 uM>
1.926

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>48.95

>  <Powder data?>
Yes

>  <IFI value>
0.051948052

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2302
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    0.5396    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  5 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  3  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
  4 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2302

>  <JC_XSMILES>
CCC1=C2C(CC3=CC=CC=C3)C(C#N)=C(N)OC2=NN1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.393

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.015384615

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2308
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1826   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7346    0.2775    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3221    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6577    1.7457    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4782    1.8319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8137    2.5856    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9631    1.1645    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5152    0.8205    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8986    0.6320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9592    0.6320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8163   -2.3784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0416   -2.3784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
 12 17  4  0  0  0  0
  9 17  4  0  0  0  0
  6 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2308

>  <JC_XSMILES>
CCC1=CC2=C(C=C1C3=CSC(NC(N)=N)=N3)C(C)(C)CCC2(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.733

>  <W2 Pf proliferation inhibition EC50 uM>
0.961

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
24.57

>  <Powder data?>
Yes

>  <IFI value>
0.051546392

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2309
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -5.2520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -3.8230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -9.4875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.9000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  4 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 14 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
M  CHG  2  22   1  23  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2309

>  <JC_XSMILES>
CC1=CC(=C(Cl)C=C1Cl)S(=O)(=O)NC(CC2=CC=C(C=C2)[N+]([O-])=O)C(O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.391

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.010309278

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2311
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2311

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.723

>  <W2 Pf proliferation inhibition EC50 uM>
0.391

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2316
  Mrv1591402191617072D          

 41 45  0  0  1  0            999 V2000
    0.3392    3.5801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5942    2.7954    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0422    2.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2971    1.3977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2549    0.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0619    0.9561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3168    1.7408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1238    1.9123    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3788    2.6969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7648    2.3539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0198    3.1385    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.4849   -0.6674    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -1.0799    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.5692    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -1.3349    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.8242   -2.1195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6312   -2.2910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8861   -3.0756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6931   -3.2472    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9480   -4.0318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3341   -3.6887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5890   -4.4734    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0370   -5.0865    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.2300   -4.9149    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6780   -5.5280    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.1290   -5.3565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3839   -4.5719    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9329   -6.3126    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.3809   -6.9257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7399   -6.4842    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.9948   -7.2688    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2919   -5.8711    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.0989   -6.0426    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5271   -3.5172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9751   -4.1303    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1681   -3.9588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2721   -2.7326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 12  5  1  1  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 15 14  1  6  0  0  0
 15 16  1  0  0  0  0
 16 12  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 19 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  1  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 25 26  1  0  0  0  0
 27 26  1  1  0  0  0
 27 28  1  0  0  0  0
 29 28  1  0  0  0  0
 29 30  1  1  0  0  0
 30 31  1  0  0  0  0
 32 29  1  0  0  0  0
 32 33  1  6  0  0  0
 32 34  1  0  0  0  0
 34 35  1  1  0  0  0
 34 36  1  0  0  0  0
 36 27  1  0  0  0  0
 36 37  1  6  0  0  0
 25 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 38 41  4  0  0  0  0
 20 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2316

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1O)[C@@H]2OC[C@@H]3[C@H]2CO[C@H]3C4=CC(OC)=C(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.771

>  <W2 Pf proliferation inhibition EC50 uM>
0.388

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2317
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 10 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  2  0  0  0  0
 22 33  4  0  0  0  0
  8 33  4  0  0  0  0
  6 34  4  0  0  0  0
 34 35  4  0  0  0  0
  3 35  4  0  0  0  0
M  CHG  2  30   1  31  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2317

>  <JC_XSMILES>
COC1=CC=C(NC2=NC(NN=CC3=CC=CC(I)=C3)=NC(NC4=CC=C(C=C4)[N+]([O-])=O)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3051

>  <W2 Pf proliferation inhibition EC50 uM>
0.454

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.73

>  <Powder data?>
No

>  <IFI value>
0.058139535

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-232
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    2.2269    1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7082    0.4242    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5292    0.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8688    1.2580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6897    1.3398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1711    0.6698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8315   -0.0821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0106   -0.1640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3129   -0.7521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9803   -1.2370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7254   -2.0217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9004   -2.0217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6454   -1.2370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8649   -0.1390    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6719   -0.3106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9268   -1.0952    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2239    0.3025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0309    0.1310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5829    0.7441    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.4114    1.5511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1258    1.9636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7389    1.4115    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.4034    0.6579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8159   -0.0566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6409   -0.0566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0534   -0.7711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6409   -1.4855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8159   -1.4855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4034   -0.7711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-232

>  <JC_XSMILES>
COC1=CC=CC(=C1)C2(CCCC2)NC(=O)CCN3C=CN=C3C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.783

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2321
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 15 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  4  0  0  0  0
 24 31  4  0  0  0  0
 31 32  4  0  0  0  0
 13 32  4  0  0  0  0
 32 33  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2321

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)S(=O)(=O)C2=CN(CC3=CC=CC=C3C)C4=CC=C(OC)C=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
6.27

>  <W2 Pf proliferation inhibition EC50 uM>
3.86

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2322
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  2  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
 19 29  4  0  0  0  0
 15 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 13 32  4  0  0  0  0
 32 33  4  0  0  0  0
  9 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2322

>  <JC_XSMILES>
CCN1CCN(CC1)C2=CC(C)=C3C=C(NC(=O)C4=CC(=O)C5=CC=CC=C5O4)C=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.498

>  <W2 Pf proliferation inhibition EC50 uM>
0.386

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.091954023

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2324
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2890   -4.3257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8671   -5.1657    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3822   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7177   -6.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2328   -7.2542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5877   -7.1680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9232   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4383   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7437   -6.3281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5642   -6.2418    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8300   -7.1485    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6575   -5.5076    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0339   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8186   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9901   -2.4922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7747   -2.2373    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.3770   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5924   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8113   -5.0794    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.6589   -4.8969    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9938   -3.9271    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
  5 19  4  0  0  0  0
  2 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
  4 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2324

>  <JC_XSMILES>
CN1N=C(C(C(=O)NC2=CC=CC(=C2)C(F)(F)F)=C1SCC3=CC=C(Cl)C=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.014

>  <W2 Pf proliferation inhibition EC50 uM>
1.203

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
31.29

>  <Powder data?>
Yes

>  <IFI value>
0.025316456

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2326
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -9.0750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
  5 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  3 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2326

>  <JC_XSMILES>
COC1=CC(CNCCCN(C)C)=CC=C1OCC2=CC=C(F)C=C2Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.092

>  <W2 Pf proliferation inhibition EC50 uM>
0.1594

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.16

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2328
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5017    0.9826    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.9866    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8116    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5017    2.3174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7566    3.1021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 14 20  4  0  0  0  0
 20 21  4  0  0  0  0
 10 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  8 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2328

>  <JC_XSMILES>
CN(C)CCCNC1=NN2C(=O)C3=C(SC(C)=C3C)N=C2C4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
6.6

>  <W2 Pf proliferation inhibition EC50 uM>
2.299

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
60.04

>  <Powder data?>
Yes

>  <IFI value>
0.125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2333
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  8 18  4  0  0  0  0
 13 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
 19 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2333

>  <JC_XSMILES>
CCC(C)NC(=O)C1=NN(C(=O)C2=CC=CC=C12)C3=CC=CC(OC)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.967

>  <W2 Pf proliferation inhibition EC50 uM>
3.81

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2341
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -0.7878   -6.0604    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5023   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5023   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3429   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  4  0  0  0  0
 15 16  2  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
  8 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
  6 22  4  0  0  0  0
  2 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2341

>  <JC_XSMILES>
ClC1=CC=CC(CN2C3=C(CCCC3)C(=N)C4=C2CCC4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.992

>  <W2 Pf proliferation inhibition EC50 uM>
0.378

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2344
  Mrv1591402191617072D          

 19 19  0  0  0  0            999 V2000
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2344

>  <JC_XSMILES>
CCCCCCCCCCCCN1C=CC(=N)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.321

>  <W2 Pf proliferation inhibition EC50 uM>
0.1882

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.99

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2345
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    5.5322   -2.2844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1732   -2.7260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3662   -2.5545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1113   -1.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4703   -1.3283    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0223   -0.7152    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6784    1.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4854    0.9526    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.0374    1.5657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8444    1.3941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0993    0.6095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5473   -0.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7403    0.1680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1883   -0.4451    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
  8 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 15 20  4  0  0  0  0
  9 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
 31 32  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2345

>  <JC_XSMILES>
CC1=CC=CC(=N1)C2N(CCC3=C2NC4=CC=CC=C34)C(=O)CCCN5CCCCC5=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.77

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2346
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    3.1113   -1.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4703   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0223   -0.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8293   -0.8867    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  4  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
 11 16  4  0  0  0  0
  5 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  10
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2346

>  <JC_XSMILES>
CC(C)C1N(CCC2=C1NC3=CC=CC=C23)C(=O)CCl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.498

>  <W2 Pf proliferation inhibition EC50 uM>
0.377

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.12

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2349
  Mrv1591402191617072D          

 31 34  0  0  1  0            999 V2000
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  1 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 18 17  1  0  0  0  0
 18 13  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 16 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2349

>  <JC_XSMILES>
C(COC1=CC=CC=C1)NCCN2CCN(C[C@@H]2CC3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2613

>  <W2 Pf proliferation inhibition EC50 uM>
0.1997

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>5.32

>  <Powder data?>
No

>  <IFI value>
0.012345679

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2350
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2398   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9049   -4.1974    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 16  1  0  0  0  0
  9 17  4  0  0  0  0
  5 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2350

>  <JC_XSMILES>
BrC1=CC=C2N=CN=C(NCC3CCCO3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.75

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.026315789

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2354
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    4.8246   -0.8575    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2726   -1.4706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5275   -2.2552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3345   -2.4268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5895   -3.2114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0374   -3.8245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2304   -3.6530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9755   -2.8683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6090    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6090   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.1759    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.3235    2.0009    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    7.0380    0.7634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    0.3509    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6077   -2.1241    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -3.8061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -3.8061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.0215    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  2  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
  9 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  3  0  0  0  0
 21 24  1  0  0  0  0
 24 25  3  0  0  0  0
 20 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
M  CHG  2  17   1  18  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2354

>  <JC_XSMILES>
OC(C1=CC=CC=C1)=C(SC2=CC=C(C=C2)[N+]([O-])=O)C(C(C#N)C#N)C3=CC=CS3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.351

>  <W2 Pf proliferation inhibition EC50 uM>
0.661

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.7

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2358
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -4.1974    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
  6 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2358

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C=CC(OC)=CC2=C1NCC3=CC=CS3

>  <PF proliferation inhibition 3D7 EC50 uM>
5.9

>  <W2 Pf proliferation inhibition EC50 uM>
3.72

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2360
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  3  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  9 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2360

>  <JC_XSMILES>
C1CN(CCO1)C2=CC(=NC(=N2)C3=CC=CC=N3)C4=CC=CC=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.907

>  <W2 Pf proliferation inhibition EC50 uM>
0.372

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2361
  Mrv1591402191617072D          

 27 31  0  0  0  0            999 V2000
   -1.9562   -0.8856    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042   -1.4986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481   -2.1661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612   -2.7181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612   -3.5431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -3.9556    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -3.5431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -2.7181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -2.3056    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -4.7806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -5.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -6.0181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0047   -6.4306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7191   -6.0181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7191   -5.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0047   -4.7806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  2 10  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  3 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 19 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2361

>  <JC_XSMILES>
O=C1N(CC2CN(CCN12)CC3=CC=CC=C3)CC4=CC5=CC=CC=C5S4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.436

>  <W2 Pf proliferation inhibition EC50 uM>
0.372

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.042857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2364
  Mrv1591402191617072D          

 24 28  0  0  0  0            999 V2000
   -3.3320   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0945    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2695    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0396   -1.0396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8520    0.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1375   -0.2750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5770    0.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4945    0.8800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1375    1.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8520    0.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0396    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
  7 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  1  0  0  0  0
 17 22  4  0  0  0  0
  8 23  1  0  0  0  0
  4 23  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2364

>  <JC_XSMILES>
OCCN1C(=O)C2C(C3C4=CC=CC=C4C2C5=CC=CC=C35)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.7

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2366
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -1.5241   -2.8772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6995   -2.9030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2649   -2.2017    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5597   -2.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9497   -2.9545    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9943   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6043   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0390   -0.0980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8636   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2982    0.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1228    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -0.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0781   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6108   -1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4141   -2.3078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3745   -1.1947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0758   -1.6293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3140   -0.3719    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9440    0.1607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2535   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8189   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2089   -2.2790    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  1  0  0  0  0
 13 20  4  0  0  0  0
  9 20  4  0  0  0  0
 20 21  4  0  0  0  0
  6 21  4  0  0  0  0
 21 22  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2366

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C=CC3=C(C(C)=C(C)N3C)C2=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.37

>  <W2 Pf proliferation inhibition EC50 uM>
0.37

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2373
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4743   -2.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4243   -1.7779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8936   -0.6509    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6782   -0.3960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3457   -0.8809    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6782    0.4290    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8936    0.6840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6387    1.4686    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3457    0.9140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0994    0.5784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7668    1.0633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6806    1.8838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9269    2.2194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2594    1.7344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
  3 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 21 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
  7 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2373

>  <JC_XSMILES>
CCN1C2=CC=C(C=C2C(C)(C)\C1=C\C=C3/SC(=S)N(C3=O)C4=CC=CC=C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1285

>  <W2 Pf proliferation inhibition EC50 uM>
0.318

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.66

>  <Powder data?>
No

>  <IFI value>
0.25

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2376
  Mrv1591402191617072D          

 42 46  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  3 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  2  0  0  0  0
 32 34  4  0  0  0  0
 24 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 35 40  4  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2376

>  <JC_XSMILES>
CCC(N(CCC1=CC=CC=C1)C(=O)NC2=CC=CC=C2OC)C3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5OC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.026

>  <W2 Pf proliferation inhibition EC50 uM>
0.366

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009433962

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2378
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.8756   -3.6020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7006   -2.1730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
 17 18  2  0  0  0  0
 14 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  10
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2378

>  <JC_XSMILES>
CCC(C)NC(=O)C1=CNC2=CC=C(C=C2C1=O)S(=O)(=O)N(C)C3=CC(C)=CC=C3C

>  <PF proliferation inhibition 3D7 EC50 uM>
5.22

>  <W2 Pf proliferation inhibition EC50 uM>
2.169

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
59.28

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2381
  Mrv1591402191617072D          

 48 52  0  0  0  0            999 V2000
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -12.3750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737  -14.0250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026  -14.8500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315  -14.0250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605  -14.8500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749  -16.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894  -16.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894  -17.3250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749  -17.7375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749  -18.5625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894  -18.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039  -18.5625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605  -17.3250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605  -16.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 29 34  1  0  0  0  0
 32 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 39 43  4  0  0  0  0
 43 44  4  0  0  0  0
 36 44  4  0  0  0  0
 23 45  4  0  0  0  0
 45 46  4  0  0  0  0
 20 46  4  0  0  0  0
  7 47  4  0  0  0  0
 47 48  4  0  0  0  0
  4 48  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2381

>  <JC_XSMILES>
CCOC1=CC=C(CN2CCN(CC2)CC(O)COC3=CC=C(OCC(O)CN4CCN(CC4)CC5=CC=C(OCC)C=C5)C=C3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.372

>  <W2 Pf proliferation inhibition EC50 uM>
2.682

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
73.65

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2385
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
    5.0013   -2.8875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  1  0  0  0  0
 14 19  4  0  0  0  0
  6 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
 20 27  4  0  0  0  0
 27 28  4  0  0  0  0
  4 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 29 34  1  0  0  0  0
 27 35  1  0  0  0  0
 35 36  1  0  0  0  0
 35 37  2  0  0  0  0
M  CHG  4   1  -1   2   1  35   1  36  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2385

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(C(=O)N2CC(=O)NC3=CC=CC=C23)=C(N4CCCCC4)C(=C1N5CCCCC5)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.194

>  <W2 Pf proliferation inhibition EC50 uM>
1.828

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
50.36

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2388
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -7.0125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 21 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2388

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)S(=O)(=O)C3=CC=C4C=CC=CC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2816

>  <W2 Pf proliferation inhibition EC50 uM>
0.2005

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>5.54

>  <Powder data?>
No

>  <IFI value>
0.101851852

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-239
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
  8 19  4  0  0  0  0
 19 20  4  0  0  0  0
  5 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-239

>  <JC_XSMILES>
CC(C)(C)C1=CC=C(NC(=O)CN2CCCCC2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>8.77

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
49.7

>  <Powder data?>
Yes

>  <IFI value>
0.026548673

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2390
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 13 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
 11 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2390

>  <JC_XSMILES>
CCCCN(C)C(=O)CSC1=NC(NCC2=CC=CC=C2)=C3C=CC=CC3=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.646

>  <W2 Pf proliferation inhibition EC50 uM>
0.361

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2391
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    2.6996   -1.0703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8963   -0.2691    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6601    0.0428    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5995    0.8656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2295    1.3982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0833    2.2101    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0058    1.1189    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6358    1.6515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4896    2.4634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1196    2.9960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8959    2.7167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5259    3.2493    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.0422    1.9048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8184    1.6255    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4121    1.3722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7983    1.0622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3637    0.3610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391    0.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1045   -0.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2799   -0.2887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1101    0.4383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3245    1.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1491    1.1137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5837    1.8150    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8176    2.1212    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7523    2.6226    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4083    1.7892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
  8 15  4  0  0  0  0
  4 16  4  0  0  0  0
 16 17  4  0  0  0  0
  2 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 16 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2391

>  <JC_XSMILES>
CN1N=C(C(=O)NC2=CC=C(F)C(Cl)=C2)C3=C1C4=CC=CC=C4S(=O)(=O)C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.61

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2393
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 13 20  4  0  0  0  0
  6 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  2  0  0  0  0
 27 29  4  0  0  0  0
  5 29  4  0  0  0  0
 29 30  4  0  0  0  0
  2 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2393

>  <JC_XSMILES>
CC1=CC=C2N(CCCC(=O)NC3=CC(C)=CC(C)=C3)C4=CC=CC=C4C(=O)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.28

>  <W2 Pf proliferation inhibition EC50 uM>
3.61

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2396
  Mrv1591402191617072D          

 11 13  0  0  0  0            999 V2000
   -1.0396    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5082    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  2 11  1  0  0  0  0
  5 11  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2396

>  <JC_XSMILES>
O=C1CCC2C3CC(C=C3)C12

>  <PF proliferation inhibition 3D7 EC50 uM>
1.776

>  <W2 Pf proliferation inhibition EC50 uM>
0.447

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>12.39

>  <Powder data?>
No

>  <IFI value>
0.0125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2399
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    6.6154    4.0876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2029    3.3731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3779    3.3731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9654    2.6586    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
    4.2509    3.0711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2509    3.8961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9654    4.3086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6799    2.2461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6799    1.4211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9654    1.0086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5529    1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7279    1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700    1.2008    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656    1.0173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206    1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062    1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917    1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917    2.3566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062    2.7691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206    2.3566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656    2.8710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700    2.6874    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  4 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 12 22  1  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2399

>  <JC_XSMILES>
CCC[P+](CCC)(CCC)CC1OCC2=CC=CC=C2CO1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.805

>  <W2 Pf proliferation inhibition EC50 uM>
3.6

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2404
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    3.5724    0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599   -7.1230    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849   -8.5520    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
  9 30  4  0  0  0  0
 30 31  4  0  0  0  0
  6 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2404

>  <JC_XSMILES>
FC(F)(F)SC1=CC=C(NC(=O)NC2=CC=CN=C2N3CCC(CC3)C(F)(F)F)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.77

>  <W2 Pf proliferation inhibition EC50 uM>
1.423

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
39.66

>  <Powder data?>
Yes

>  <IFI value>
0.073394495

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2405
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2405

>  <JC_XSMILES>
CC1CCCN(C1)C(=O)C2CCN(CC2)CC3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.14

>  <W2 Pf proliferation inhibition EC50 uM>
3.58

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2409
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2409

>  <JC_XSMILES>
CCC(CO)NC1=NC=CN=C1C2=CC=CC=C2OC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
4.54

>  <W2 Pf proliferation inhibition EC50 uM>
3.56

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2411
  Mrv1591402191617072D          

 35 37  0  0  0  0            999 V2000
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3427   -4.9455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5357   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1232   -4.4025    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6753   -3.7894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5037   -2.9825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2809   -2.7275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4524   -1.9206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1607   -1.3685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0108   -0.5616    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.9453   -1.6235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5584   -1.0714    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.1168   -2.4304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2002   -5.8707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1354   -6.6244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5535   -5.5351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9539   -6.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 14 21  4  0  0  0  0
 11 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  4 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 28 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2411

>  <JC_XSMILES>
CC(C)N(CC(=O)NC1=CC(=NN1C2=CC=C(Cl)C(Cl)=C2)C(C)(C)C)C(=O)C3=CC=C(Cl)C(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.014

>  <W2 Pf proliferation inhibition EC50 uM>
0.356

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2412
  Mrv1591402191617072D          

 16 18  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6561   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4407   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4407   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6561   -0.0305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  1  0  0  0  0
  6 11  4  0  0  0  0
  3 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2412

>  <JC_XSMILES>
CN1C(N(C)C2=CC=CC=C12)C3=CC=CO3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2883

>  <W2 Pf proliferation inhibition EC50 uM>
0.356

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.014285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2413
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
  6 12  4  0  0  0  0
  4 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 14 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2413

>  <JC_XSMILES>
CC1=CC(NC2=CC=CC(Cl)=C2)=NC(NCC3=CC=CC=C3)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.051

>  <W2 Pf proliferation inhibition EC50 uM>
0.607

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.06

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2415
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    6.2970   -4.6383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4900   -4.4668    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2351   -3.6821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4281   -3.5106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1732   -2.7260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4703   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.0694    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1544   -0.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5322   -2.2844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7871   -3.0690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 13 23  4  0  0  0  0
 16 23  4  0  0  0  0
  6 24  4  0  0  0  0
 24 25  4  0  0  0  0
  3 25  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2415

>  <JC_XSMILES>
COC1=CC=C(CNC2=NC=NC3=C2NC4=CC(OC)=CC=C34)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.958

>  <W2 Pf proliferation inhibition EC50 uM>
0.856

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
24.09

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2419
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -3.4105    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.3033   -4.8395    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
  4 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 17 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2419

>  <JC_XSMILES>
CC1=CC(NC2=CC=CC(=C2)C(F)(F)F)=NC(NCC3=CC=CC=C3)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1782

>  <W2 Pf proliferation inhibition EC50 uM>
0.553

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.59

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2420
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8671   -5.1657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3822   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7177   -6.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2328   -7.2542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5877   -7.1680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9232   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4383   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 13 22  4  0  0  0  0
 10 22  4  0  0  0  0
  2 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 23 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2420

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)C2=NOC(CCC3=CC=CC=C3)=N2)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.903

>  <W2 Pf proliferation inhibition EC50 uM>
0.554

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.67

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2424
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  2  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 13 19  4  0  0  0  0
  9 19  4  0  0  0  0
 19 20  2  0  0  0  0
  7 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2424

>  <JC_XSMILES>
CCCN1C(=N)C(=CC2=C1N=C3N(C=CC=C3C)C2=O)C(=O)NC(C)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.648

>  <W2 Pf proliferation inhibition EC50 uM>
3.53

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2426
  Mrv1591402191617072D          

 20 23  0  0  0  0            999 V2000
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 Se  0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0645   -0.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6165   -1.2553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3615   -2.0399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5546   -2.2114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0025   -1.5983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
  9 14  4  0  0  0  0
  6 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  CHG  1   8   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2426

>  <JC_XSMILES>
C[N+]1=C2[Se]CC(=NN2C3=CC=CC=C13)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.471

>  <W2 Pf proliferation inhibition EC50 uM>
0.832

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.61

>  <Powder data?>
Yes

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2430
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 17 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2430

>  <JC_XSMILES>
COC1=CC=CC(=C1)C(=O)N(C)CCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.39

>  <W2 Pf proliferation inhibition EC50 uM>
0.2082

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.93

>  <Powder data?>
No

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2432
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    2.5645    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801   -1.0164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
  7 30  4  0  0  0  0
  3 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2432

>  <JC_XSMILES>
COC1=CC=CC(CNC2=NC=NC3=C2C(C)=C(S3)C(=O)NCC4COCCO4)=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.01

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2434
  Mrv1591402191617072D          

 18 21  0  0  0  0            999 V2000
    3.4767   -0.6691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7467   -1.4486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5569   -1.6046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0970   -0.9809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9071   -1.1368    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4472   -0.5132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1771    0.2664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7172    0.8900    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5274    0.7341    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7974   -0.0454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6075   -0.2014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8776   -0.9809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3375   -1.6046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5274   -1.4486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2573   -0.6691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3670    0.4223    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8269   -0.2014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0168   -0.0454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  4  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  6 15  4  0  0  0  0
 10 15  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
  1 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2434

>  <JC_XSMILES>
C1=CC=C2N=C3C(N=NC4=CC=CC=C34)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.104

>  <W2 Pf proliferation inhibition EC50 uM>
0.996

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
28.49

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2436
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    3.9849   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -7.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -7.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572   -7.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9862   -7.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7006   -6.9020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4151   -7.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4151   -8.1395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.1296   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5421   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9546   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6690   -7.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3835   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0980   -7.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0980   -8.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3835   -8.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6690   -8.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2436

>  <JC_XSMILES>
CCCCCCCCNC(=O)C1CC1C2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>10.53

>  <W2 Pf proliferation inhibition EC50 uM>
3.49

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.018181818

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2438
  Mrv1591402191617072D          

 33 34  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5395   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9520   -4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
  8 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
  3 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
M  CHG  2  31   1  32  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2438

>  <JC_XSMILES>
CCC(OC1=CC=C(C=C1C(C)(C)CC)C(C)(C)CC)C(=O)NC2=CC=C(Cl)C(=C2)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2749

>  <W2 Pf proliferation inhibition EC50 uM>
0.349

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.024793388

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-244
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -2.3541   -4.4425    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1826   -3.6356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7346   -3.0225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3221   -2.3080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5152   -2.4795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0714   -2.2201    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5564   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0714   -3.5549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3814   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7939   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6189   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0314   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6189   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7939   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  2  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-244

>  <JC_XSMILES>
O=C1CCCN1CCCNC(=O)C2=CC=C3N=C(SC3=C2)N4CCOCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
7.24

>  <W2 Pf proliferation inhibition EC50 uM>
4.69

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
26.75

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2442
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 16 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 33 34  4  0  0  0  0
 24 34  4  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2442

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1OC)C(=O)NC(C2=CC=CC=C2Cl)C3=CC(Cl)=C4C=CC=NC4=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
6.15

>  <W2 Pf proliferation inhibition EC50 uM>
3.47

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2447
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 16 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2447

>  <JC_XSMILES>
COCC(=O)N(C)CCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1558

>  <W2 Pf proliferation inhibition EC50 uM>
0.346

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2448
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -4.2868   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
  8 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 16 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2448

>  <JC_XSMILES>
NC1=NC(N)=C2C=C(C=CC2=N1)S(=O)(=O)C3=CC=C4C=CC=CC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0973

>  <W2 Pf proliferation inhibition EC50 uM>
1.709

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
49.48

>  <Powder data?>
Yes

>  <IFI value>
0.124031008

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-245
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -3.8837   -7.1282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -4.9848    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-245

>  <JC_XSMILES>
CCCOC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)C3=NC4=NC=CC=C4O3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.415

>  <W2 Pf proliferation inhibition EC50 uM>
>1.751

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2452
  Mrv1591402191617072D          

 35 39  0  0  1  0            999 V2000
   -4.2738   -1.7023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5579   -2.1123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8449   -1.6974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4299   -2.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2599   -0.9843    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1319   -1.2824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1347   -0.4574    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4160   -1.6924    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7029   -1.2774    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.2126   -1.6278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0158   -2.5124    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.6972   -2.9274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7317   -2.9224    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.7346   -3.7474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4448   -2.5075    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2330   -2.2640    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4530   -2.5791    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1148   -1.8266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7260   -1.2724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7231   -0.4474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4362   -0.0325    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1521   -0.4425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8651   -0.0275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8622    0.7975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5810   -0.4375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5839   -1.2625    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.2998   -1.6725    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8708   -1.6775    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8737   -2.5025    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1549   -1.2675    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.4126   -2.0512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4419   -1.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0072   -0.0374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7058   -0.4524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4217   -0.0424    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  9  8  1  1  0  0  0
  9 10  1  0  0  0  0
 11 10  1  0  0  0  0
 11 12  1  6  0  0  0
 11 13  1  0  0  0  0
 13 14  1  6  0  0  0
 13 15  1  0  0  0  0
 15 16  1  6  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 26 25  1  0  0  0  0
 26 27  1  6  0  0  0
 28 26  1  0  0  0  0
 28 29  1  1  0  0  0
 30 28  1  0  0  0  0
 30 22  1  0  0  0  0
 30 31  1  1  0  0  0
 30 32  1  0  0  0  0
 15 32  1  0  0  0  0
 19 32  1  0  0  0  0
 20 33  1  0  0  0  0
 33 34  1  0  0  0  0
  9 34  1  0  0  0  0
 34 35  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2452

>  <JC_XSMILES>
CCC(C)(O)C(=O)O[C@@H]1C2[C@@H](C)[C@@H](O)[C@@]3(O)OCC24C(CC5C(C)=C[C@H](O)[C@@H](O)[C@]5(C)C34)OC1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2267

>  <W2 Pf proliferation inhibition EC50 uM>
0.2148

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.25

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2455
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    5.3033   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5408   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9533   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7783   -0.9355    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1908   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7783    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0158   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4283   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.4283    0.4934    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.2533    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6658    1.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4908    1.2079    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.9757    1.8753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7603    1.6204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7603    0.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9757    0.5404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6658   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4908   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9033   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4908   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6658   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2533   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1908   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.9052   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6033   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4237   -2.4507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9758   -1.8376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5953   -3.2577    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8808   -3.6702    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.2677   -3.1181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4607   -3.2897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 11 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  5 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2455

>  <JC_XSMILES>
COCCN(C(C)C(=O)NC(CN1CCCC1)C2=CC=CC=C2)S(=O)(=O)C3=C(C)ON=C3C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.964

>  <W2 Pf proliferation inhibition EC50 uM>
0.406

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.86

>  <Powder data?>
No

>  <IFI value>
0.009803922

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2456
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 10 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
  6 25  4  0  0  0  0
 25 26  4  0  0  0  0
  3 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2456

>  <JC_XSMILES>
COC1=CC=C(NC(=O)C2=C(C)NC(=S)NC2C3=CC=C(O)C=C3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.424

>  <W2 Pf proliferation inhibition EC50 uM>
0.342

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2458
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    0.6159   -2.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4229   -2.4457    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4758    0.3498    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2828    0.5213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5377    1.3059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3447    1.4774    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5996    2.2621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4066    2.4336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9586    1.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7037    1.0359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8967    0.8644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
  9 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  8 22  4  0  0  0  0
 22 23  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  4  0  0  0  0
  3 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   7
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2458

>  <JC_XSMILES>
COC1=CC=C2NC3=C(NCCN4CCCCC4)N=CN=C3C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.785

>  <W2 Pf proliferation inhibition EC50 uM>
0.976

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
28.56

>  <Powder data?>
Yes

>  <IFI value>
0.097560976

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2459
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -2.2673    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  6 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2459

>  <JC_XSMILES>
CCOC(=O)C1=C(NC(C)=O)SC2=C1CCN(C2)C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.558

>  <W2 Pf proliferation inhibition EC50 uM>
3.41

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2461
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
   -5.1212    5.0178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    5.0178    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    4.3034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    4.3034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919   -4.6024    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
  6 33  4  0  0  0  0
 33 34  4  0  0  0  0
  3 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2461

>  <JC_XSMILES>
COC1=CC=C(CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(F)C=C5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.447

>  <W2 Pf proliferation inhibition EC50 uM>
0.711

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.89

>  <Powder data?>
Yes

>  <IFI value>
0.023668639

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2463
  Mrv1591402191617072D          

 15 15  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2539   -2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6039   -2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
  6 15  4  0  0  0  0
  2 15  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2463

>  <JC_XSMILES>
FC1=CC=CC(NNC(=O)C(F)(F)F)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.67

>  <W2 Pf proliferation inhibition EC50 uM>
0.34

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.0125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2465
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 12 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2465

>  <JC_XSMILES>
CC1=CC=CC=C1NC(=S)NC(CC2=CC=CC=C2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.374

>  <W2 Pf proliferation inhibition EC50 uM>
0.34

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.068181818

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2466
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 11 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
  9 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2466

>  <JC_XSMILES>
CC1=CC=CC=C1NC2=NC(NCC3=CC=CO3)=C4C=CC=CC4=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.548

>  <W2 Pf proliferation inhibition EC50 uM>
0.529

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.6

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2468
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
 12 17  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  11
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2468

>  <JC_XSMILES>
CCN1CCC(=CC1)C2=CNC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.885

>  <W2 Pf proliferation inhibition EC50 uM>
0.339

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2469
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -2.1434   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -3.1895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164   -1.7605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7578   -5.5020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4222   -6.2557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6018   -6.1695    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 14 12  1  4  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
  8 25  4  0  0  0  0
 25 26  4  0  0  0  0
  5 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2469

>  <JC_XSMILES>
NS(=O)(=O)C1=CC=C(CCNC(=O)C=CC2=CC=C3OCOC3=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>7.76

>  <W2 Pf proliferation inhibition EC50 uM>
3.39

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-247
  Mrv1591402191617072D          

 40 45  0  0  0  0            999 V2000
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7550   -1.5731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3070   -0.9600    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8945   -0.2455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0875   -0.4170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 12 23  4  0  0  0  0
 23 24  4  0  0  0  0
  9 24  4  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 25 30  1  0  0  0  0
 28 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 39 40  1  0  0  0  0
 31 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-247

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=CC=C(C(=O)N(C)CC3=CSC=N3)C(=N2)N4CCC(CC4)N5CCC6=CC=CC=C6C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.746

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.038461538

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2470
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9592   -2.2820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1100   -0.3837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2773    0.2871    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8986   -2.2820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1808   -3.0572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6505   -3.6892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1620   -3.5460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6923   -4.1779    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.4441   -2.7707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0862   -2.1387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
  4 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 11 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2470

>  <JC_XSMILES>
CC(=O)N1C2=CC=CC=C2C(C)(CC1(C)C)C3=CC=C(Br)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
4.27

>  <W2 Pf proliferation inhibition EC50 uM>
2.416

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
71.44

>  <Powder data?>
Yes

>  <IFI value>
0.016129032

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2474
  Mrv1591402191617072D          

 50 55  0  0  0  0            999 V2000
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8125    0.1433    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7111    1.6998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2414    2.6183    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2822   -0.7752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2481   -1.4072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0946   -0.9185    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3768   -1.6938    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1893   -1.8370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4714   -2.6123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2839   -2.7555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0017   -3.5308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9984   -3.1680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8142   -2.1235    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6267   -2.2668    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5320   -1.3483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3445   -1.2050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5320   -0.5233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7196   -1.2050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 22 30  1  0  0  0  0
 20 31  1  0  0  0  0
 15 31  1  0  0  0  0
 31 32  1  0  0  0  0
 11 32  1  0  0  0  0
 32 33  2  0  0  0  0
 17 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  2  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  2  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 40 42  1  0  0  0  0
 40 43  1  0  0  0  0
 43 44  1  0  0  0  0
 43 45  1  0  0  0  0
 45 46  1  0  0  0  0
 45 47  1  0  0  0  0
 45 48  1  0  0  0  0
 38 48  1  0  0  0  0
 12 49  4  0  0  0  0
  7 49  4  0  0  0  0
 49 50  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2474

>  <JC_XSMILES>
COC1=CC=CC2=C1C(=O)C3C(C(O)=C4CC(O)(CC(OC5CC(C)(N)C(O)CO5)C4=C3O)C(C)=NN=C6CC(C)(C)N(O)C(C)(C)C6)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.416

>  <W2 Pf proliferation inhibition EC50 uM>
0.337

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.214285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2476
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 13 20  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2476

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(C)=NNC2=NN=C(C)C(O)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1878

>  <W2 Pf proliferation inhibition EC50 uM>
0.2581

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.68

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2479
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    5.3696    2.8021    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    6.1558    2.5522    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.7654    3.1081    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3325    1.7463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1187    1.4963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2954    0.6905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0816    0.4405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8678    0.1906    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6858    0.1346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    0.3845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7229    1.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9367    1.4403    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8667    2.2624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2360    2.7942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1662    1.6853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5828    0.7397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4049    0.8096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9521    1.2715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2752    0.7999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5283    1.1503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4584    1.9723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1353    2.4439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0654    3.2660    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8822    2.0935    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4140    2.7242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8624   -0.6713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0391   -1.4772    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  3  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  4 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
 18 24  4  0  0  0  0
 24 25  1  0  0  0  0
 14 25  1  0  0  0  0
  9 26  1  0  0  0  0
 26 27  3  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2479

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(C#N)=C(C=C1N2CC3CC(C2)C4=CC=CC(=O)N4C3)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.36

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-248
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
  5 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 14 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-248

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1O)C2=NC(=C(N2)C3=CC=C(O)C=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.879

>  <W2 Pf proliferation inhibition EC50 uM>
>1.746

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2482
  Mrv1591402191617072D          

 48 55  0  0  0  0            999 V2000
   -3.4088    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6944    2.1918    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    2.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654   -1.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6944   -1.9332    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4088   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771    0.7967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320    1.5814    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8620    0.1293    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771   -0.5381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320   -1.3228    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6870    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0995    0.8438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9245    0.8438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3370    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1620    0.1293    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.9245   -0.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0995   -0.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6717    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1533    0.1293    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    2.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    3.0168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    3.4293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    3.0168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    2.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -1.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -2.7582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -3.1707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635   -2.7582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635   -1.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  4  0  0  0  0
 11 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 25 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
 21 34  1  0  0  0  0
  9 34  1  0  0  0  0
 34 35  1  0  0  0  0
 19 35  1  0  0  0  0
 35 36  2  0  0  0  0
 34 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
 19 43  1  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 43 48  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2482

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C(C3=CC=C(OC)C=C3)C4(C5C(C(=O)N(C5=O)C6=CC=C(F)C=C6)C2(C4=O)C7=CC=CC=C7)C8=CC=CC=C8

>  <PF proliferation inhibition 3D7 EC50 uM>
2.244

>  <W2 Pf proliferation inhibition EC50 uM>
3.35

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2484
  Mrv1591402191617072D          

 32 37  0  0  1  0            999 V2000
    5.5117   -4.5798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6913   -4.6660    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2063   -3.9986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3859   -4.0848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9009   -3.4174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2365   -2.6637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0570   -2.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5419   -3.2449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7516   -1.9963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9311   -2.0825    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4462   -1.4151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7817   -0.6614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6022   -0.5752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0871   -1.2426    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2968    0.0060    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.4718    0.0060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2169    0.7907    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4506    1.2756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1956    2.0602    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6294    2.0602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1143    2.7276    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8843    1.2756    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1392    2.0602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9642    2.0602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2192    1.2756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5517    0.7907    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6806    2.7276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5010    2.6414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9860    3.3088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6504    4.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8299    4.1487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3450    3.4813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 15 12  1  6  0  0  0
 15 16  1  0  0  0  0
 17 16  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 22 20  1  0  0  0  0
 17 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 15 26  1  0  0  0  0
 22 26  1  1  0  0  0
 19 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2484

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=NC=C(C=N2)[C@@H]3C[C@H]4CN(C(=O)[C@]45CCCN35)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
2.263

>  <W2 Pf proliferation inhibition EC50 uM>
0.995

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
29.8

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-249
  Mrv1591402191617072D          

 20 23  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164    1.5395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  5 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  2 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  CHG  1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-249

>  <JC_XSMILES>
C[N+]1=CC=C(C2OC2C3=CC=CC=C3)C4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
1.376

>  <W2 Pf proliferation inhibition EC50 uM>
1.744

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2492
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2297    2.0580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6166    2.6100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0366    2.2295    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3722    2.9832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4491    1.5150    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8971    0.9019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3096    0.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2696    1.4288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7546    2.0962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5750    2.0100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9106    1.2563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4257    0.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6052    0.6751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8163   -2.3784    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0417   -2.3784    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 21 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 13 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  1  0  0  0  0
  3 35  1  0  0  0  0
 35 36  2  0  0  0  0
 35 37  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2492

>  <JC_XSMILES>
CCN1C(C(=O)C2=CC=CC=C2)=C(NC3=C(C)N(C)N(C3=O)C4=CC=CC=C4)C5=CC=CC=C5S1(=O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.31

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2497
  Mrv1591402191617072D          

 34 39  0  0  0  0            999 V2000
    4.7506   -5.9555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4150   -5.2018    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5945   -5.1156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2590   -4.3619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7439   -3.6945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5644   -3.7807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8999   -4.5344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8999   -3.0270    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 17 26  4  0  0  0  0
 21 26  4  0  0  0  0
 14 27  4  0  0  0  0
  9 27  4  0  0  0  0
 13 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 33 34  4  0  0  0  0
 28 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2497

>  <JC_XSMILES>
CN1CCC2=C(C1)SC3=C2C(=O)N(C(SCC4=CC=CC5=CC=CC=C45)=N3)C6=CC=C(C)C=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
>6.52

>  <W2 Pf proliferation inhibition EC50 uM>
3.3

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.1

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2498
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    0.7145    7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.3022   -5.9305    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.4582   -5.0906    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 29 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  2  0  0  0  0
 17 35  4  0  0  0  0
 35 36  4  0  0  0  0
 14 36  4  0  0  0  0
M  CHG  2  32   1  33  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2498

>  <JC_XSMILES>
CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=CC=C(NC(=O)C3=CC=C(O3)C4=CC=C(C=C4)[N+]([O-])=O)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.214

>  <W2 Pf proliferation inhibition EC50 uM>
3.3

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2499
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
    4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 14 25  4  0  0  0  0
 20 25  4  0  0  0  0
  7 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2499

>  <JC_XSMILES>
CCCCC(=O)N(CCCC(C)NC1=CC(OC)=CC2=CC=CN=C12)CC3=CC=CC=C3OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.348

>  <W2 Pf proliferation inhibition EC50 uM>
0.035

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.062

>  <Powder data?>
No

>  <IFI value>
0.052631579

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2501
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -0.2107   -1.7450    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0392   -2.5519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5912   -3.1650    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1787   -3.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6282   -3.7080    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5143   -4.6332    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0294   -5.3006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3649   -6.0543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1854   -6.1405    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6703   -5.4731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3348   -4.7194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  2  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
 12 17  4  0  0  0  0
  4 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2501

>  <JC_XSMILES>
O=C1N=C(S\C1=C\C2=CC=CC3=CC=CC=C23)N4CCOCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.329

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2502
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    5.0953    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7808    4.6828    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3518    5.5078    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4788    5.8098    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    6.5242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3038    5.8098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7163    6.5242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5413    6.5242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9538    5.8098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5413    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7163    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -0.5422    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -0.1006    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -0.8853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -1.0568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 13 34  4  0  0  0  0
  9 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  2  0  0  0  0
 35 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2502

>  <JC_XSMILES>
CCOC(=O)N1CCC2=C(C1)SC(NC(=O)C3=CC=C(C=C3)S(=O)(=O)N(C)C4=CC=CC=C4)=C2C(=O)OCC

>  <PF proliferation inhibition 3D7 EC50 uM>
>10.58

>  <W2 Pf proliferation inhibition EC50 uM>
>3.29

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2503
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7550   -2.5519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3070   -3.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8945   -3.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0875   -3.7080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  2  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
  6 12  4  0  0  0  0
 10 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 13 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
  9 25  4  0  0  0  0
 24 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 29 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2503

>  <JC_XSMILES>
CC1=CC=CN2C(=O)C3=C(N=C12)N(CCC4=CC=CC=C4)C(=N)C(=C3)C(=O)NC5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
2.197

>  <W2 Pf proliferation inhibition EC50 uM>
3.29

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.067567568

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2506
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  3  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
  3 11  1  0  0  0  0
  7 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2506

>  <JC_XSMILES>
CSC1=C(C#N)C(CC(=O)N1)C2=CC=C(O)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.51

>  <W2 Pf proliferation inhibition EC50 uM>
3.28

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.007407407

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2509
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    7.6391    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    4.8229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
  9 21  4  0  0  0  0
 21 22  4  0  0  0  0
  6 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2509

>  <JC_XSMILES>
CCN(CC)C1=CC=C(NCC2=CC=C3OCOC3=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.603

>  <W2 Pf proliferation inhibition EC50 uM>
0.805

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
24.59

>  <Powder data?>
Yes

>  <IFI value>
0.029850746

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2512
  Mrv1591402191617072D          

 34 39  0  0  0  0            999 V2000
    2.2563    0.4587    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9237    0.9436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9237    1.7686    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7083    2.0235    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1932    1.3561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0182    1.3561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7083    0.6887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9633   -0.0960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4783   -0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6533   -0.7634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9633   -1.4308    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7083   -2.2155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2603   -2.8285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0673   -2.6570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6194   -3.2701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3644   -4.0547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5574   -4.2263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3025   -5.0109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4955   -5.1824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9435   -4.5693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1984   -3.7847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0054   -3.6132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479   -1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623   -1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768   -1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768   -0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623    0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479   -0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9633    2.8082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4112    3.4213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6662    4.2059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4731    4.3774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0252    3.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7702    2.9797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  7  5  1  4  0  0  0
  2  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 13 22  4  0  0  0  0
 17 22  4  0  0  0  0
 11 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
  8 28  1  0  0  0  0
 23 28  4  0  0  0  0
  4 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2512

>  <JC_XSMILES>
O=C1NN(C(=O)C1=C2C(=O)N(CC3=CC=CC4=CC=CC=C34)C5=CC=CC=C25)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
5.05

>  <W2 Pf proliferation inhibition EC50 uM>
3.26

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2513
  Mrv1591402191617072D          

 25 29  0  0  0  0            999 V2000
    6.2963    7.8596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7088    7.1451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2963    6.4306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4713    6.4306    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0588    7.1451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4713    7.8596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0588    5.7162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2383    5.6299    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3943    4.9625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 10 25  4  0  0  0  0
  7 25  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2513

>  <JC_XSMILES>
C1CCN(CC1)C2=NC3=C(CN(CC3)CC4=CC=C5NC=CC5=C4)S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.41

>  <W2 Pf proliferation inhibition EC50 uM>
0.326

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2514
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 11  8  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 25 26  4  0  0  0  0
 14 26  4  0  0  0  0
 19 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2514

>  <JC_XSMILES>
COC(=O)C1=CC=C(C=C1)C=NNC2=CC(C)=NC3=CC=C(OC)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2037

>  <W2 Pf proliferation inhibition EC50 uM>
0.537

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.5

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2515
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  2  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
  2 18  4  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2515

>  <JC_XSMILES>
CN1C(=O)C=C(NN=CC2=CC=CC=C2)N(C)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.325

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.022900763

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2516
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
  5 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 10 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2516

>  <JC_XSMILES>
CCCCN1CC2=CC=C(C=C2N=C1C3=CC=C(F)C=C3)C(=O)NC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.722

>  <W2 Pf proliferation inhibition EC50 uM>
0.325

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.012195122

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2518
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
    1.3222   -3.3616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -3.3616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -4.5991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -4.5991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -5.8366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -6.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2032   -6.0666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8163   -6.6186    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6010   -6.3637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7725   -5.5567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2140   -6.9157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9987   -6.6608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6118   -7.2128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4402   -8.0198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6556   -8.2747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0425   -7.7227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0533   -8.5718    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.6054   -7.9587    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5013   -9.1849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6664   -9.1238    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.4510   -8.8689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0641   -9.4209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8926  -10.2279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1080  -10.4829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4949   -9.9308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -7.1062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -7.1062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -6.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2991   -6.0666    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6860   -6.6186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0986   -6.3637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2701   -5.5567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7117   -6.9157    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4963   -6.6608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1638   -7.1457    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8312   -6.6608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5763   -5.8762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7513   -5.8762    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
  9 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
  8 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  2  0  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 37 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2518

>  <JC_XSMILES>
CC1=CC=CC(=C1)N2C(CNC(=O)C3=CC=C(C=C3)S(=O)(=O)N4CCCCC4)=NN=C2SCC(=O)NC5=NC=CS5

>  <PF proliferation inhibition 3D7 EC50 uM>
4.2

>  <W2 Pf proliferation inhibition EC50 uM>
2.173

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
67.1

>  <Powder data?>
Yes

>  <IFI value>
0.011904762

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2520
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7250   -0.1085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3776    0.3790    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2026    0.3790    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4576   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7901   -0.8905    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 10 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
  6 29  4  0  0  0  0
 29 30  4  0  0  0  0
  3 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2520

>  <JC_XSMILES>
COC1=CC=C(NC(=O)C2=C(NC(=O)C3=CC=CO3)N(N=C2)C4=CC=CC=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
8

>  <W2 Pf proliferation inhibition EC50 uM>
3.23

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011764706

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2521
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -2.3034   -1.2615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7514   -1.8746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9444   -1.7031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3924   -2.3162    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4146   -2.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6695   -1.3601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4765   -1.1885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0285   -1.8016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8535   -1.8016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4056   -1.1885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2125   -1.3601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4675   -2.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2744   -2.3162    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8265   -1.7031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6334   -1.8746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1855   -1.2615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9154   -2.7578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1085   -2.5862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4410   -3.0712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4410   -3.8962    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7266   -4.3087    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7266   -5.1337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4410   -5.5462    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0121   -5.5462    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7736   -2.5862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9666   -2.7578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 19 25  1  0  0  0  0
  8 25  4  0  0  0  0
 25 26  4  0  0  0  0
  5 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2521

>  <JC_XSMILES>
CCCOC1=CC=C2C3=CC=C(OCCC)C=C3C(=NNC(N)=N)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2696

>  <W2 Pf proliferation inhibition EC50 uM>
0.323

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2522
  Mrv1591402191617072D          

 41 44  0  0  0  0            999 V2000
   -4.7651   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2251   -2.0171    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4149   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8748   -1.5493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5246   -1.0816    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444   -2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261    0.3216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362    0.1657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763    0.7893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6864    0.6334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9565   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7666   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3067    0.3216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6864   -1.5493    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4966   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -1.7052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164   -2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763   -3.5762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261   -4.0439    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.7961   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -2.4848    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.7946   -2.4848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9845   -2.6407    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2546   -4.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647   -3.8880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3347   -3.1084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1449   -2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 14 23  4  0  0  0  0
 12 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 27 33  4  0  0  0  0
 33 34  1  0  0  0  0
  5 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 35 40  4  0  0  0  0
 40 41  4  0  0  0  0
  3 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2522

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=C(OC)C(OC)=C2)C(=O)NC3=CC=CC(Cl)=C3Cl)=C4N=CC=CC4=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.691

>  <W2 Pf proliferation inhibition EC50 uM>
0.203

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.29

>  <Powder data?>
No

>  <IFI value>
0.064220183

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2526
  Mrv1591402191617072D          

 38 42  0  0  1  0            999 V2000
    2.9646   -2.5366    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.2501   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2501   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5356   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8212   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -5.0116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7741   -5.4965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5192   -6.2812    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.3058   -6.2812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5607   -5.4965    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.3454   -5.2416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9584   -5.7936    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5169   -4.4346    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9038   -3.8826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0753   -3.0756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8599   -2.8207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0315   -2.0137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4184   -1.4617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6337   -1.7166    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4622   -2.5236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0041   -6.9486    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8246   -6.8624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1602   -6.1087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9806   -6.0224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -6.6899    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1300   -7.4436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3095   -7.5298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2861   -6.6036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6216   -5.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4421   -5.7637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7776   -5.0101    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5981   -4.9238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0831   -5.5913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7475   -6.3449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9270   -6.4312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8212   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5356   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  9  8  1  0  0  0  0
  9 10  1  0  0  0  0
 11 10  1  0  0  0  0
 11  7  1  0  0  0  0
 11 12  1  1  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  9 22  1  1  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
  5 37  4  0  0  0  0
 37 38  4  0  0  0  0
  2 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2526

>  <JC_XSMILES>
ClC1=CC=C(CN2C[C@H](C[C@H]2C(=O)NCC3=CC=CN=C3)NC4CCN(CC4)CCC5=CC=CC=C5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0885

>  <W2 Pf proliferation inhibition EC50 uM>
0.592

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.47

>  <Powder data?>
Yes

>  <IFI value>
0.028846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2529
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    3.1599   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  2  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 14 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2529

>  <JC_XSMILES>
CC(C)(CCl)C(=O)NCCCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.386

>  <W2 Pf proliferation inhibition EC50 uM>
0.361

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.3

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2531
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    2.3271   -6.9562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7751   -6.3432    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0300   -5.5585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919   -4.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8989   -4.4309    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4509   -5.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8370   -5.3870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3890   -6.0001    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1341   -6.7847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
  5 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
  3 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  CHG  2  19   1  20  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2531

>  <JC_XSMILES>
COC1=CC(NC(=O)CN2C=CC3=CC=C(C=C23)[N+]([O-])=O)=CC(OC)=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.439

>  <W2 Pf proliferation inhibition EC50 uM>
0.319

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2532
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3848   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8545   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  3  0  0  0  0
 13 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 16 23  4  0  0  0  0
 23 24  4  0  0  0  0
 11 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2532

>  <JC_XSMILES>
CC(C)CN1CCN(CC1)C2=NC(C#N)=C3COC(C)(C)CC3=C2C(=S)NC4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.37

>  <W2 Pf proliferation inhibition EC50 uM>
0.319

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2537
  Mrv1591402191617072D          

 37 42  0  0  0  0            999 V2000
  -10.0360   -3.6088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.5057   -2.9769    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -8.6932   -3.1201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1629   -2.4881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3505   -2.6314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0683   -3.4066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2558   -3.5499    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7255   -2.9179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0077   -2.1427    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9131   -3.0612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3196   -2.4881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5912   -2.8754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8159   -2.5932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1839   -3.1235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3272   -3.9360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1025   -4.2182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7344   -3.6879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5514   -3.8027    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654   -3.6538    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5986   -4.0386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4111   -3.8954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 19 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  4  0  0  0  0
 27 35  4  0  0  0  0
  6 36  4  0  0  0  0
 36 37  4  0  0  0  0
  3 37  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  35
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2537

>  <JC_XSMILES>
COC1=CC=C(NC(=O)C2=CC3=CC(=CC=C3O2)C4(O)CCN(CC4)CC5=CC6=CC=CC=C6N5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.272

>  <W2 Pf proliferation inhibition EC50 uM>
0.65

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.48

>  <Powder data?>
Yes

>  <IFI value>
0.084745763

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2538
  Mrv1591402191617072D          

 17 17  0  0  0  0            999 V2000
   -1.4709   -1.5832    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7564   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1689   -2.7102    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3439   -1.2812    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0419   -2.4082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0419   -3.2332    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6725   -1.9957    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3870   -2.4082    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1015   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1015   -1.1707    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8159   -2.4082    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5304   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2449   -2.4082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9986   -2.0727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5506   -2.6857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1381   -3.4002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3311   -3.2287    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2538

>  <JC_XSMILES>
FC(F)(F)C(=O)NNC(=S)NCC1=CC=CO1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.17

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.02020202

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2540
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -2.1434   13.3661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   12.9536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   12.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   11.7161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   10.8911    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   10.8911    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    9.6536    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.9411    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674    4.2187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    4.2187    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    9.6536    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    8.4161    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   10.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 13 22  4  0  0  0  0
 22 23  4  0  0  0  0
 10 23  4  0  0  0  0
  9 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 24 31  2  0  0  0  0
  5 31  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2540

>  <JC_XSMILES>
CCCCN1C(=O)NC(C2=CC=C(NC(=O)C3=CC=CS3)C=C2)C(C(=O)OC(C)C)=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
8.76

>  <W2 Pf proliferation inhibition EC50 uM>
3.17

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.064102564

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2542
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 18  6  1  4  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2542

>  <JC_XSMILES>
CCOC1=CC(=CC=C1OCC2=CC=CC=C2)C=NN=C(N)N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2346

>  <W2 Pf proliferation inhibition EC50 uM>
0.321

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.14

>  <Powder data?>
Yes

>  <IFI value>
0.02238806

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2543
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -2.1434    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  1  0  0  0  0
  6 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2543

>  <JC_XSMILES>
ClC1=CC=C2C(NCCCCNS(=O)(=O)C3=CC(Cl)=CC=C3Cl)=CC=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.391

>  <W2 Pf proliferation inhibition EC50 uM>
0.338

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.69

>  <Powder data?>
No

>  <IFI value>
0.038461538

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2544
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8020   -1.6545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6090   -1.4830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0215   -2.1975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4694   -2.8106    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  2  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 12 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 30 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2544

>  <JC_XSMILES>
CCCCCN1C(=O)C2=CC=C(C=C2N=C1SCC3=CC=C(C)C=C3)C(=O)NCC4=CC=CO4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.157

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2546
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2546

>  <JC_XSMILES>
COC1=CC=CC=C1N2CCN(CC2)C(=O)NC3=CC=C4C=CC=CC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.285

>  <W2 Pf proliferation inhibition EC50 uM>
0.3151

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2552
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0597   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8443   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0158   -0.7221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4027   -0.1701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5743    0.6369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3589    0.8918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9720    0.3398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8004   -0.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1953   -2.5687    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0203   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5052   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3257   -3.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8106   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5557   -4.6019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2231   -5.0868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8905   -4.6019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6752   -4.8569    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -3.6356   -3.8173    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2752   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0598   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2314   -0.7221    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6729   -2.0811    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  3 11  4  0  0  0  0
 11 12  4  0  0  0  0
 13 12  1  4  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 15 20  4  0  0  0  0
 12 21  4  0  0  0  0
  2 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2552

>  <JC_XSMILES>
CC1=C(CC2=CC=CC=C2)SC(N=CC3=CC=C(Br)S3)=C1C(N)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.445

>  <W2 Pf proliferation inhibition EC50 uM>
0.3136

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2555
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  1  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 10 23  4  0  0  0  0
 14 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2555

>  <JC_XSMILES>
C(CN1CCOCC1)NC2=CC=NC3=CC4=CC=CC=C4C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3104

>  <W2 Pf proliferation inhibition EC50 uM>
0.3132

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2559
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2448   -0.6055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1842   -0.6055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  8 16  1  0  0  0  0
  6 17  4  0  0  0  0
  2 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2559

>  <JC_XSMILES>
CC1=CC=CC(NC2=NC(N)=NC(C)(C)N2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0576

>  <W2 Pf proliferation inhibition EC50 uM>
0.3119

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2561
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    5.7158    1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   16.4328   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 16 26  4  0  0  0  0
 20 26  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2561

>  <JC_XSMILES>
ClC1=CC=C(OCC(=O)NCCCCNC2=CC=NC3=CC(Cl)=CC=C23)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2398

>  <W2 Pf proliferation inhibition EC50 uM>
0.3028

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>9.74

>  <Powder data?>
No

>  <IFI value>
0.02970297

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2562
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 19 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2562

>  <JC_XSMILES>
CCCCC1=CC=C(C=C1)C(=O)NCCCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.221

>  <W2 Pf proliferation inhibition EC50 uM>
0.3108

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.021276596

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2563
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -3.4105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -4.8395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -5.4394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -6.0525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -6.7670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731   -6.5955    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
  5 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
 21 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 18 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2563

>  <JC_XSMILES>
CC1=CC=C(C=C1S(=O)(=O)NCC2CCCO2)C3=NN=C(NC4=CC=C(F)C=C4)C5=CC=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
1.705

>  <W2 Pf proliferation inhibition EC50 uM>
3.108

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.060606061

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2564
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -3.1612   -4.9580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8757   -4.5455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8757   -3.7205    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5902   -3.3080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3047   -3.7205    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5902   -2.4830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8757   -2.0705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0472   -1.2636    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8677   -1.1773    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2033   -1.9310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0238   -2.0172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5087   -1.3498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1731   -0.5961    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6581    0.0713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3526   -0.5099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1612   -2.4830    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1612   -3.3080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4468   -3.7205    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7323   -3.3080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0178   -3.7205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0178   -4.5455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3034   -3.3080    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4111   -3.7205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1256   -3.3080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8400   -3.7205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5545   -3.3080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2690   -3.7205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2690   -4.5455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5545   -4.9580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8400   -4.5455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  2  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
  9 15  1  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
  3 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2564

>  <JC_XSMILES>
CCN1C(=O)C2=C(SC3=C2CCN(C)C3)N=C1SCC(=O)NCCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>4.82

>  <W2 Pf proliferation inhibition EC50 uM>
3.104

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.08

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2567
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2567

>  <JC_XSMILES>
CCN1CCN(CC1)CC2=CC=C(C=C2)N(CC)CC

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.083

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2568
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
  5 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 19 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  CHG  2   8   1   9  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2568

>  <JC_XSMILES>
CC1=CC=C(C=C1[N+]([O-])=O)C(=O)NCCCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2225

>  <W2 Pf proliferation inhibition EC50 uM>
0.3083

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.021052632

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2569
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
    2.8579   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -9.1474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -9.1474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
  4 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
  2 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 29 32  1  0  0  0  0
 32 33  2  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 32 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2569

>  <JC_XSMILES>
ClC1=CC(C(=O)NC2=CC=C(C=C2)C3=NCCN3)=C(Cl)C=C1C(=O)NC4=CC=C(C=C4)C5=NCCN5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.066

>  <W2 Pf proliferation inhibition EC50 uM>
0.3081

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-257
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7179    2.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4630    2.8207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0150    3.4338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8220    3.2623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769    2.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-257

>  <JC_XSMILES>
CCSC1=NC=NC2=C1C(=CS2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.509

>  <W2 Pf proliferation inhibition EC50 uM>
1.712

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.011904762

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2570
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -0.7145   -4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105   -3.7125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5395   -3.7125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2570

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(=C1)N2N=NC3=CC=CC=C3C2=N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1343

>  <W2 Pf proliferation inhibition EC50 uM>
0.3079

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.025316456

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2571
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 10 21  4  0  0  0  0
 15 21  4  0  0  0  0
 17 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2571

>  <JC_XSMILES>
CCN1CCN(CC1)CC2=CC(=O)OC3=CC(=C(O)C=C23)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2841

>  <W2 Pf proliferation inhibition EC50 uM>
0.385

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.52

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2574
  Mrv1591402191617072D          

 27 29  0  0  1  0            999 V2000
    0.1715    0.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1146   -0.7363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1487   -0.2549    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.5612    0.4595    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5612   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3862   -0.9694    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7987   -1.6839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6237   -1.6839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0362   -2.3984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6237   -3.1128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7987   -3.1128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3862   -2.3984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5612   -2.3984    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.1487   -1.6839    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.1487   -3.1128    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0362   -3.8273    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    7.8612   -3.8273    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    6.6237   -4.5418    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0937   -1.7070    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  4  1  6  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  0  0  0  0
  8  9  1  1  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 15 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
  7 24  1  0  0  0  0
 24 25  1  0  0  0  0
 26 24  1  0  0  0  0
 26  5  1  0  0  0  0
 26 27  1  6  0  0  0
  2 27  1  0  0  0  0
M  CHG  4  18   1  19  -1  21   1  22  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2574

>  <JC_XSMILES>
CC1(C)O[C@@H]2OC([C@@H](O)CNC3=CC=C(C=C3[N+]([O-])=O)[N+]([O-])=O)C(O)[C@@H]2O1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.299

>  <W2 Pf proliferation inhibition EC50 uM>
0.366

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.95

>  <Powder data?>
Yes

>  <IFI value>
0.007462687

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2575
  Mrv1591402191617072D          

 33 34  0  0  0  0            999 V2000
    1.5466   -6.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3662   -5.9376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5301   -7.3571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7105   -7.4517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6774   -6.5054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1692   -7.1678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9887   -7.0732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4805   -7.7356    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3000   -7.6410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6278   -6.8839    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.7917   -8.3034    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6113   -8.2088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9391   -7.4517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7587   -7.3571    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2504   -8.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0700   -7.9249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0865   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9061   -6.5054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4639   -9.0605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9557   -9.7229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7752   -9.6283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2669  -10.2907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0865  -10.1961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5782  -10.8585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3978  -10.7639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7256  -10.0068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2504  -11.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4309  -11.7102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9391  -11.0478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1196  -11.1424    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6278  -10.4800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8083  -10.5746    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 12 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 23 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 21 32  4  0  0  0  0
 32 33  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  31
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2575

>  <JC_XSMILES>
CCN(CC)CCCNC(=S)N(CCN(CC)CC)CC1=CC2=CC(CC)=CC=C2NC1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.375

>  <W2 Pf proliferation inhibition EC50 uM>
1.387

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
45.63

>  <Powder data?>
Yes

>  <IFI value>
0.046296296

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2576
  Mrv1591402191617072D          

 35 37  0  0  0  0            999 V2000
    3.8123   -5.0434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6050   -4.8146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1995   -5.3867    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2087   -6.4163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9921   -5.1578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5866   -5.7299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3792   -5.5011    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9737   -6.0731    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7663   -5.8443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9645   -5.0434    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.3608   -6.4163    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1626   -7.2172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3700   -7.4460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1718   -8.2468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3792   -8.4756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7847   -7.9036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9921   -8.1324    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3976   -7.5604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -7.1028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7755   -6.8739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1534   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7479   -6.7595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5405   -6.5307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1350   -7.1028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9276   -6.8739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5221   -7.4460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3148   -7.2172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.5129   -6.4163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3240   -8.2468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5313   -8.4756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9368   -7.9036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1442   -8.1324    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.5497   -7.5604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7571   -7.7892    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  4  0  0  0  0
 14 21  4  0  0  0  0
 12 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 25 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 23 34  4  0  0  0  0
 34 35  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  33
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2576

>  <JC_XSMILES>
CCN(CC)CCCNC(=S)N(CC1=CC=C(OC)C=C1)CC2=CC3=CC(CC)=CC=C3NC2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
3.46

>  <W2 Pf proliferation inhibition EC50 uM>
0.554

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.24

>  <Powder data?>
Yes

>  <IFI value>
0.082706767

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2577
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
  2 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2577

>  <JC_XSMILES>
CC1=CC=C(NC(=O)COC2=CC=C(Cl)C=C2Cl)N=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>5.57

>  <W2 Pf proliferation inhibition EC50 uM>
>3.026

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2578
  Mrv1591402191617072D          

136143  0  0  1  0            999 V2000
   41.6403  -13.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   41.7081  -13.0572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   42.4541  -12.7049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   41.0300  -12.5874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   41.0978  -11.7652    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   40.4197  -11.2954    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   39.6737  -11.6477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   39.6059  -12.4700    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   38.9956  -11.1779    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   39.0634  -10.3557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   38.2496  -11.5303    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   37.5715  -11.0605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   37.6393  -10.2382    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   36.8255  -11.4128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   36.1474  -10.9430    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   35.4014  -11.2954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   35.3336  -12.1176    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   34.7232  -10.8255    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   33.9773  -11.1779    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   33.2991  -10.7081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   32.5532  -11.0605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   34.7911  -10.0033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   34.1129   -9.5335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   35.5370   -9.6510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   41.8438  -11.4128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   41.9116  -10.5906    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   42.5219  -11.8827    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   43.2679  -11.5303    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   43.3357  -10.7081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   43.9460  -12.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   43.8782  -12.8223    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   44.6920  -11.6477    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   45.3701  -12.1176    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   45.3023  -12.9398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   45.9805  -13.4096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   44.5564  -13.2922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   46.1161  -11.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   46.1839  -10.9430    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   46.7942  -12.2350    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   47.5402  -11.8827    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   47.6080  -11.0605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   48.3540  -10.7081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   46.9299  -10.5906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   48.2183  -12.3525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   48.1505  -13.1747    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   48.9643  -12.0001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   49.6425  -12.4700    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   49.5746  -13.2922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   50.2528  -13.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   48.8287  -13.6445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   50.3884  -12.1176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   50.4562  -11.2954    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   51.0666  -12.5874    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   51.8125  -12.2350    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   51.8803  -11.4128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   52.6263  -11.0605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   53.3498  -11.4568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   53.9504  -10.8912    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   53.5980  -10.1452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   53.9166   -9.3842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   53.4168   -8.7278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   52.5985   -8.8324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   52.2799   -9.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   52.7797  -10.2498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   52.4907  -12.7049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   52.4229  -13.5271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   53.2366  -12.3525    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   53.9148  -12.8223    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   53.8470  -13.6445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   54.5251  -14.1144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   55.2711  -13.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   54.4573  -14.9366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   54.6607  -12.4700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   54.7285  -11.6477    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   55.3389  -12.9398    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   56.0848  -12.5874    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   56.1527  -11.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   56.8986  -11.4128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   57.6222  -11.8092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   58.2227  -11.2436    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   57.8703  -10.4976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   58.1889   -9.7366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   57.6891   -9.0802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   56.8708   -9.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   56.5522   -9.9458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   57.0520  -10.6022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   56.7630  -13.0572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   56.6952  -13.8795    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   57.5089  -12.7049    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   58.1871  -13.1747    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   58.1193  -13.9969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   58.7974  -14.4667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   59.5434  -14.1144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   58.7296  -15.2890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   58.9331  -12.8223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   59.0009  -12.0001    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   59.6112  -13.2922    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   60.3572  -12.9398    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   60.4250  -12.1176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   61.1709  -11.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   61.8945  -12.1616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   62.4950  -11.5959    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   62.1427  -10.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   62.4612  -10.0890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   61.9615   -9.4326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   61.1431   -9.5372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   60.8246  -10.2982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   61.3243  -10.9546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   61.0353  -13.4096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   60.9675  -14.2318    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   61.7813  -13.0572    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   62.4594  -13.5271    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   62.3916  -14.3493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   63.0697  -14.8191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   63.8157  -14.4667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   63.0019  -15.6413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   63.2054  -13.1747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   63.2732  -12.3525    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   63.8835  -13.6445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   64.6295  -13.2922    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   65.3076  -13.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   66.0536  -13.4096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   66.2070  -12.5990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   67.0253  -12.4944    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   67.3777  -13.2404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   68.1678  -13.4776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   68.3574  -14.2806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   67.7568  -14.8462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   66.9667  -14.6089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   66.7771  -13.8060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   64.6973  -12.4700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   65.4433  -12.1176    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   64.0191  -12.0001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   64.0870  -11.1779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   63.4088  -10.7081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   63.4766   -9.8859    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  4  1  0  0  0  0
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  6  7  1  0  0  0  0
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 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
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 15 16  1  0  0  0  0
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 18 16  1  0  0  0  0
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 18 22  1  0  0  0  0
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 22 24  1  0  0  0  0
  5 25  1  0  0  0  0
 25 26  2  0  0  0  0
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 33 34  1  0  0  0  0
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 37 38  2  0  0  0  0
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 41 42  1  0  0  0  0
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 47 48  1  0  0  0  0
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 48 50  1  0  0  0  0
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 51 52  2  0  0  0  0
 51 53  1  0  0  0  0
 54 53  1  1  0  0  0
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 55 56  1  0  0  0  0
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 58 59  4  0  0  0  0
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 99100  1  0  0  0  0
100101  4  0  0  0  0
101102  4  0  0  0  0
102103  4  0  0  0  0
103104  4  0  0  0  0
104105  4  0  0  0  0
105106  4  0  0  0  0
106107  4  0  0  0  0
107108  4  0  0  0  0
100108  4  0  0  0  0
103108  4  0  0  0  0
 98109  1  0  0  0  0
109110  2  0  0  0  0
109111  1  0  0  0  0
112111  1  1  0  0  0
112113  1  0  0  0  0
113114  1  0  0  0  0
114115  1  0  0  0  0
114116  1  0  0  0  0
112117  1  0  0  0  0
117118  2  0  0  0  0
117119  1  0  0  0  0
120119  1  6  0  0  0
120121  1  0  0  0  0
121122  1  0  0  0  0
122123  4  0  0  0  0
123124  4  0  0  0  0
124125  4  0  0  0  0
125126  4  0  0  0  0
126127  4  0  0  0  0
127128  4  0  0  0  0
128129  4  0  0  0  0
129130  4  0  0  0  0
122130  4  0  0  0  0
125130  4  0  0  0  0
120131  1  0  0  0  0
131132  2  0  0  0  0
131133  1  0  0  0  0
133134  1  0  0  0  0
134135  1  0  0  0  0
135136  1  0  0  0  0
M  STY  4   1 DAT   2 DAT   3 DAT   4 DAT
M  SAL   1  1  58
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  80
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  SAL   3  1 102
M  SDT   3 MRV_IMPLICIT_H                                        
M  SDD   3     0.0000    0.0000    DR    ALL  0       0  
M  SED   3 IMPL_H1
M  SAL   4  1 124
M  SDT   4 MRV_IMPLICIT_H                                        
M  SDD   4     0.0000    0.0000    DR    ALL  0       0  
M  SED   4 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2578

>  <JC_XSMILES>
CC(C)C[C@@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC3=CNC4=CC=CC=C34)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC5=CNC6=CC=CC=C56)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC7=CNC8=CC=CC=C78)C(=O)NCCO

>  <PF proliferation inhibition 3D7 EC50 uM>
2.889

>  <W2 Pf proliferation inhibition EC50 uM>
2.986

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
98.83

>  <Powder data?>
Yes

>  <IFI value>
0.276422764

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-258
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
    0.8838    0.7541    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  6 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 13 20  4  0  0  0  0
  3 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
  2 23  4  0  0  0  0
  4 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-258

>  <JC_XSMILES>
BrC1=C2C(=NN(C3=CC=CC=C3)C(C4=CC=CC=C4)=C2C(Br)=C1)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.753

>  <W2 Pf proliferation inhibition EC50 uM>
>1.712

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2581
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    4.8607    3.2726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5752    3.6851    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2897    3.2726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0042    3.6851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7186    3.2726    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.4331    3.6851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1476    3.2726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1476    2.4476    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.8620    3.6851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5765    3.2726    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.2910    3.6851    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.0054    3.2726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7591    3.6081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0141    4.3927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.8210    4.5643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3731    3.9512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1181    3.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3112    2.9950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8987    2.2806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1536    1.4959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6016    0.8828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7946    1.0544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5397    1.8390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0917    2.4521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 12 24  1  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2581

>  <JC_XSMILES>
COCCNCC(O)CON=C1C2=CC=CC=C2C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
4.79

>  <W2 Pf proliferation inhibition EC50 uM>
0.704

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.33

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2583
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    7.6391    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
  6 23  4  0  0  0  0
 23 24  4  0  0  0  0
  3 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2583

>  <JC_XSMILES>
COC1=CC=C(CN2CCC3=C(C2)SC(=N3)N4CCCCC4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2927

>  <W2 Pf proliferation inhibition EC50 uM>
0.3014

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.097222222

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2585
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  7 15  4  0  0  0  0
 10 15  4  0  0  0  0
  8 16  4  0  0  0  0
  3 16  4  0  0  0  0
 16 17  1  0  0  0  0
M  CHG  1   3   1
M  STY  1   1 DAT
M  SAL   1  1   9
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2585

>  <JC_XSMILES>
CC[N+]1=C(C)C=C2C(NC3=CC=CC=C23)=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.242

>  <W2 Pf proliferation inhibition EC50 uM>
3

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2587
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    2.0367    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    4.4759    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    2.0009    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.1759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.1759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8476   -0.5465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926   -1.3312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676   -1.3312    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -0.5465    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  2  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2587

>  <JC_XSMILES>
CC1=CC(Br)=CC(Cl)=C1OC(=O)C2=CC=NO2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.998

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.016528926

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2588
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2588

>  <JC_XSMILES>
OC1=CC=CC=C1NC(=O)C2=CC=C(Cl)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
3.26

>  <W2 Pf proliferation inhibition EC50 uM>
1.086

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
36.23

>  <Powder data?>
Yes

>  <IFI value>
0.051282051

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2589
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9151   -2.8830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1081   -3.0545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6956   -2.3400    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2476   -1.7269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0761   -0.9200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2915   -0.6650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1199    0.1419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7330    0.6940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5615    1.5009    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.5177    0.4390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1308    0.9911    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.6892   -0.3679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7725   -3.8082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4370   -4.5619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0189   -3.4726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5262   -4.1437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 14 21  4  0  0  0  0
 11 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  4 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 36 37  4  0  0  0  0
 28 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2589

>  <JC_XSMILES>
CC(C)N(CC(=O)NC1=CC(=NN1C2=CC=C(Cl)C(Cl)=C2)C(C)(C)C)C(=O)C3=CC=C4C=CC=CC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.313

>  <W2 Pf proliferation inhibition EC50 uM>
2.997

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-259
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    7.6391    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.8085    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
 17 32  4  0  0  0  0
 13 32  4  0  0  0  0
 32 33  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-259

>  <JC_XSMILES>
COC1=CC=CC=C1NC(=O)CN2C=NC3=C(C(C)=C(S3)C(=O)NC4=CC=C(F)C=C4)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.513

>  <W2 Pf proliferation inhibition EC50 uM>
>1.711

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2591
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    1.7605    5.5243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1730    4.8099    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7605    4.0954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1730    3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7605    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9355    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020    0.5230    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9355    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7605    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1730    1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020    3.3809    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230    3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9355    4.0954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5395    2.6664    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9520    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7770    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1895    2.6664    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7770    3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9520    3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0145    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4270    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2520    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6645    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4895    2.6664    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2520    3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4270    3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  8 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  6 17  4  0  0  0  0
 17 18  4  0  0  0  0
  3 18  4  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 22 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2591

>  <JC_XSMILES>
COC1=CC=C2C=C(CNCCCO)C(=NC2=C1)N3CCN(CC3)C4=CC=C(F)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.99

>  <W2 Pf proliferation inhibition EC50 uM>
0.6

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.05

>  <Powder data?>
Yes

>  <IFI value>
0.01

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2593
  Mrv1591402191617072D          

 42 48  0  0  0  0            999 V2000
    1.8163   -1.5534    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8163   -2.3784    0.0000 Si  0  0  0  0  0  0  0  0  0  0  0  0
    1.1018   -2.7909    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3874   -2.3784    0.0000 Si  0  0  0  0  0  0  0  0  0  0  0  0
    0.3874   -1.5534    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1018   -1.1409    0.0000 Si  0  0  0  0  0  0  0  0  0  0  0  0
    0.5084   -0.5678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2847   -0.7952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8781   -0.2221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6785    0.5784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1145    0.8058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7080    0.2327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4891   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0520    0.2872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4393    1.0156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2638    1.0444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7010    0.3448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3136   -0.3837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1878   -3.1789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7812   -3.7520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5816   -4.5525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2114   -4.7799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8049   -4.2068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6053   -3.4063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4371   -2.4072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8245   -3.1356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6490   -3.1644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0861   -2.4648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6988   -1.7363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8743   -1.7076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6093   -2.1510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8089   -1.3505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -1.1231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1954   -1.6962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9958   -2.4967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2028   -2.7241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2535   -3.0780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0780   -3.0492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5152   -3.7489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1279   -4.4773    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3034   -4.5061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8662   -3.8065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  6 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  4 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
  4 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
  2 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
  2 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2593

>  <JC_XSMILES>
N1[Si](N[Si](N[Si]1(C2=CC=CC=C2)C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7

>  <PF proliferation inhibition 3D7 EC50 uM>
0.521

>  <W2 Pf proliferation inhibition EC50 uM>
0.2988

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.01980198

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2595
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.1347   -1.5983    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.1966   -0.6422    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
  9 14  4  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
M  CHG  2  15   1  16  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2595

>  <JC_XSMILES>
CN1C2=CC=NC=C2C3=CC(=CC=C13)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.833

>  <W2 Pf proliferation inhibition EC50 uM>
0.938

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
31.42

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2596
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
   -1.8212   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    1.4455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8792    1.5317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4312    0.9186    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0507    2.3387    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3362    2.7512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1647    3.5581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3801    3.8131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7670    3.2611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9385    2.4541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7231    2.1991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.9979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  2  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  5 14  4  0  0  0  0
  9 14  4  0  0  0  0
  2 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 23 30  4  0  0  0  0
 19 30  4  0  0  0  0
 30 31  1  0  0  0  0
 17 31  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2596

>  <JC_XSMILES>
O=C(CCN1C(=O)NC2=CC=CC=C12)NCC3CC4=CC=CC(C5=CC=NC=C5)=C4O3

>  <PF proliferation inhibition 3D7 EC50 uM>
3.25

>  <W2 Pf proliferation inhibition EC50 uM>
2.983

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2598
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -5.0850    0.4135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3688    0.8231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3655    1.6481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6493    2.0577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9365    1.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9399    0.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2271    0.4018    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5110    0.8114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5076    1.6364    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7526    0.3695    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2622    0.3731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2791   -0.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0497   -0.8176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8029   -0.4811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0976    0.2895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7611    1.0427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9905    1.3374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2373    1.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7507    0.2525    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1959    0.0417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8443   -0.5704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6538   -1.3731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1366   -1.6095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3271   -2.4122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2728   -2.9785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0632   -2.7422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2537   -1.9395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6560    0.4077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 11 18  1  0  0  0  0
 17 19  1  0  0  0  0
 13 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
  6 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2598

>  <JC_XSMILES>
CC1=CC=CC(NC(=S)NC2CC3CCCC(C2)N3CCC4=CC=CC=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.668

>  <W2 Pf proliferation inhibition EC50 uM>
0.914

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
30.68

>  <Powder data?>
Yes

>  <IFI value>
0.025641026

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2599
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -3.6020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.1730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
 12  9  1  4  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 15 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 13 28  1  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2599

>  <JC_XSMILES>
CC1=CC=C(C)C(=C1)S(=O)(=O)N=C2C=C(SCC(O)=O)C(=O)C3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
3.6

>  <W2 Pf proliferation inhibition EC50 uM>
0.527

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.71

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-260
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -2.2673    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  6 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 21 26  4  0  0  0  0
 26 27  2  0  0  0  0
 26 28  4  0  0  0  0
 17 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-260

>  <JC_XSMILES>
CC(C)CCN1C(NCC2=CC=CC=C2)=NC3=C1C(=O)N(CC(N)=O)C(=O)N3C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.709

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2600
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -2.4243   -2.6350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6397   -2.3800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4681   -1.5731    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0202   -0.9600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8407   -1.0462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6077   -0.2455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9432    0.5082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007   -0.4170    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  3  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
M  CHG  1  21   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2600

>  <JC_XSMILES>
CCN1C(C)=C(C)S\C1=C/C2=CC=C3C=C(C)C=CC3=[N+]2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2272

>  <W2 Pf proliferation inhibition EC50 uM>
0.1697

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.72

>  <Powder data?>
Yes

>  <IFI value>
0.113636364

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2602
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    4.5317    4.7499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3602    3.9429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5756    3.6880    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4040    2.8810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0171    2.3290    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6194    2.6261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    3.1110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    3.9360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2845    2.6261    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3244    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1090    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1090    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3244   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  1  0  0  0  0
 13 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 10 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2602

>  <JC_XSMILES>
CCOC(=O)C1=C(C)OC2=C1C3=C(OCN(C3)C4CCCC4)C5=CC=CC=C25

>  <PF proliferation inhibition 3D7 EC50 uM>
11.06

>  <W2 Pf proliferation inhibition EC50 uM>
2.961

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2603
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 16  1  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
  7 23  4  0  0  0  0
  5 24  4  0  0  0  0
 24 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2603

>  <JC_XSMILES>
FC1=CC=C(NC2=NC(NCC3CCCO3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2143

>  <W2 Pf proliferation inhibition EC50 uM>
0.2818

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.53

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2604
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  4  0  0  0  0
  4 15  4  0  0  0  0
 15 16  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   7
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2604

>  <JC_XSMILES>
CCCC1=C(C)N=C2C=CC(C)=CC2=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
3.22

>  <W2 Pf proliferation inhibition EC50 uM>
2.955

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2606
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3440   -8.6580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5370   -8.8295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1245   -8.1150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6766   -7.5019    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
  8 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 16 26  4  0  0  0  0
 26 27  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  25
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2606

>  <JC_XSMILES>
CCCCNC(=S)N(CC1=CC=CS1)CC2=CC3=CC(C)=CC=C3NC2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.02

>  <W2 Pf proliferation inhibition EC50 uM>
0.295

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018181818

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2608
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6081   -2.8265    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2608

>  <JC_XSMILES>
COC1=CC=CC=C1N2C(S)=NN=C2C3=CC=CC=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2763

>  <W2 Pf proliferation inhibition EC50 uM>
0.2948

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2614
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6586   -3.7080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4656   -3.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8781   -3.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3260   -2.5519    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  7 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
 21 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2614

>  <JC_XSMILES>
CC(C)NC(=O)C1=CC(NC(=O)C2=CC=CS2)=CC=C1N3CCC4=CC=CC=C4C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.262

>  <W2 Pf proliferation inhibition EC50 uM>
0.479

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.34

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2616
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -2.7555    5.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2706    4.8867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6062    4.1330    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1213    3.4656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3008    3.5518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8158    2.8844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1514    2.1307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8158    1.3770    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9719    2.0445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4568    2.7119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 10 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  9 21  4  0  0  0  0
 21 22  4  0  0  0  0
  7 22  4  0  0  0  0
 22 23  4  0  0  0  0
  4 23  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2616

>  <JC_XSMILES>
CCOC1=CC=C2NC3=C(NCCCN(C)C)N=CN=C3C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2033

>  <W2 Pf proliferation inhibition EC50 uM>
0.778

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
26.56

>  <Powder data?>
Yes

>  <IFI value>
0.033333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2619
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6766    0.9019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1245    1.5150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5370    2.2295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3440    2.0580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 16 25  1  0  0  0  0
  9 26  4  0  0  0  0
 26 27  4  0  0  0  0
  2 27  4  0  0  0  0
  6 27  4  0  0  0  0
  4 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 28 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2619

>  <JC_XSMILES>
CC1=CC(=NC2=CC=C(NC(=S)NCCN3CCC4=CC=CC=C4C3)C=C12)N5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.044

>  <W2 Pf proliferation inhibition EC50 uM>
0.629

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.54

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2620
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 11 17  4  0  0  0  0
  6 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2620

>  <JC_XSMILES>
CN(C)C1=CC(NC(=O)NC2=CC=CC(Cl)=C2)=C3C=CC=CC3=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0765

>  <W2 Pf proliferation inhibition EC50 uM>
0.292

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076388889

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2621
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -4.5527   -1.1585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0007   -1.7716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1937   -1.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6417   -2.2131    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4856   -2.8806    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -3.4326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -4.2576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -4.6701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -4.2576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -3.4326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -3.0201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  4 12  1  0  0  0  0
  7 12  4  0  0  0  0
  5 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 17 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 16 27  4  0  0  0  0
M  CHG  1  17   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2621

>  <JC_XSMILES>
C=CCN1C(\SC2=CC=CC=C12)=C\C=C\C3=[N+](CC=C)C4=CC=CC=C4S3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.032

>  <W2 Pf proliferation inhibition EC50 uM>
0.2918

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2622
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 16 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 13 30  4  0  0  0  0
 11 31  4  0  0  0  0
  6 31  4  0  0  0  0
 31 32  4  0  0  0  0
  3 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2622

>  <JC_XSMILES>
COC1=CC=C2N=C(C)C=C(NC3=CC=C(OC4=CC=C5C=CC=CC5=C4)C(Cl)=C3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1656

>  <W2 Pf proliferation inhibition EC50 uM>
0.2062

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.07

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2625
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -1.5371    1.2687    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710    3.7211    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8128   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4628   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.3646    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 15 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2625

>  <JC_XSMILES>
OC1=CC=C(Cl)C=C1NC(=O)C2=C3N=C(C=C(N3N=C2)C(F)(F)F)C4=CC=C(F)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>8.74

>  <W2 Pf proliferation inhibition EC50 uM>
2.914

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022988506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2626
  Mrv1591402191617072D          

 35 37  0  0  0  0            999 V2000
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 13 25  2  0  0  0  0
 25 26  1  4  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  2  0  0  0  0
  9 35  4  0  0  0  0
  5 35  4  0  0  0  0
M  CHG  2  32   1  33  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2626

>  <JC_XSMILES>
COC(=O)C1=CC=CC(NC(=O)C(NC(=O)C2=CC=CC=C2OC)=CC3=CC=CC(=C3)[N+]([O-])=O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.994

>  <W2 Pf proliferation inhibition EC50 uM>
2.913

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2628
  Mrv1591402191617072D          

 41 44  0  0  0  0            999 V2000
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 10 23  4  0  0  0  0
 23 24  2  0  0  0  0
  8 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 36 39  4  0  0  0  0
 30 39  4  0  0  0  0
  6 40  4  0  0  0  0
 40 41  4  0  0  0  0
  3 41  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  22
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2628

>  <JC_XSMILES>
COC1=CC=C(CN(CC2=CC3=CC(OC)=C(OC)C=C3NC2=O)C(=S)NCCC4=CC=C(OC)C(OC)=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
5.58

>  <W2 Pf proliferation inhibition EC50 uM>
1.038

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
35.68

>  <Powder data?>
Yes

>  <IFI value>
0.054054054

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2630
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4521   -2.7050    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4521   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6236   -1.8980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4082   -1.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0213   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8059   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9775   -1.1332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3644   -0.5812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5797   -0.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5359    0.2258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7074    1.0328    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7289    0.3973    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3429    0.0543    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2630

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2C(S)=NN=C2CNC3=CC=CC(=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
4.86

>  <W2 Pf proliferation inhibition EC50 uM>
2.908

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.016949153

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2634
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2634

>  <JC_XSMILES>
OC1=CC2=CC=CC=C2C=C1C(=O)NC3=CC=CC(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.545

>  <W2 Pf proliferation inhibition EC50 uM>
0.2287

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.89

>  <Powder data?>
Yes

>  <IFI value>
0.096153846

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2636
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.8923    1.5907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3078    2.3034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1328    2.2999    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5484    3.0126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1389    3.7288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5545    4.4415    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1450    5.1578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5606    5.8705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3856    5.8669    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7950    5.1507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3795    4.4380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8011    6.5796    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0884    6.9952    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5138    6.1641    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2166    7.2924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8072    8.0086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2227    8.7213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8133    9.4375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0477    8.7178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4572    8.0015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0416    7.2888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4511    6.5726    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.5423    1.5837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1267    0.8710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5362    0.1547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1206   -0.5580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2956   -0.5544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2326    0.1301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3017    0.8745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8862    0.1618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1594    0.5522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1561   -0.2224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 21 22  1  0  0  0  0
  3 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
 29 30  1  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2636

>  <JC_XSMILES>
CCN(CCN1CCN(CC1)S(=O)(=O)C2=CC(Cl)=CC=C2Cl)CC3=CCC4CC3C4(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.793

>  <W2 Pf proliferation inhibition EC50 uM>
0.2892

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2638
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3149   -0.4305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1354   -0.3443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4710   -1.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2582   -0.8513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0262   -1.7081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9684   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3184   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 12 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2638

>  <JC_XSMILES>
CC(NCCCN(C)C)C1=CC(=CC2=C1CCC2(C)C)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.62

>  <W2 Pf proliferation inhibition EC50 uM>
0.1789

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.22

>  <Powder data?>
Yes

>  <IFI value>
0.106060606

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2639
  Mrv1591402191617072D          

 55 61  0  0  0  0            999 V2000
   -3.8837   -4.2703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -3.9979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -6.4729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0087   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  2  0  0  0  0
 35 37  1  0  0  0  0
 37 38  2  0  0  0  0
 38 39  1  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 39 44  4  0  0  0  0
 24 45  4  0  0  0  0
 45 46  4  0  0  0  0
 21 46  4  0  0  0  0
 46 47  4  0  0  0  0
 19 47  4  0  0  0  0
  2 48  1  0  0  0  0
 48 49  2  0  0  0  0
 49 50  1  0  0  0  0
 50 51  4  0  0  0  0
 51 52  4  0  0  0  0
 52 53  4  0  0  0  0
 53 54  4  0  0  0  0
 54 55  4  0  0  0  0
 50 55  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  47
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2639

>  <JC_XSMILES>
O=C(NC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C3=NC4=CC=C(NC(=O)C5=CC=CC=C5NC(=O)\C=C\C6=CC=CC=C6)C=C4N3)\C=C\C7=CC=CC=C7

>  <PF proliferation inhibition 3D7 EC50 uM>
0.347

>  <W2 Pf proliferation inhibition EC50 uM>
0.382

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>13.29

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2641
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.3315    0.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.9959    1.3057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.1754    1.2195    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 19 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  2  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 27 38  4  0  0  0  0
 32 38  4  0  0  0  0
  6 39  4  0  0  0  0
 39 40  4  0  0  0  0
  3 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2641

>  <JC_XSMILES>
COC1=CC=C(NC(=O)CCCCCN2C(=O)C3=C(C=CS3)N=C2SCC4=CC(=O)OC5=CC(O)=CC=C45)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
5.82

>  <W2 Pf proliferation inhibition EC50 uM>
2.866

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2642
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -2.8739   -1.8358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1595   -2.2483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4450   -1.8358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7305   -2.2483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0161   -1.8358    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6984   -2.2483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4129   -1.8358    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6984   -3.0733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4129   -3.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4129   -4.3108    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6984   -4.7233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0161   -4.3108    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0161   -3.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7305   -3.0733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0161   -1.0108    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6835   -0.5259    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4286    0.2587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3964    0.2587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6514   -0.5259    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135    0.9261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7340    0.8399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2189    1.5074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0394    1.4211    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3749    0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8833    2.2610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0628    2.3473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5779    1.6798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2426    1.7661    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7275    1.0986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
  5 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 20 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2642

>  <JC_XSMILES>
CCCCN(C(=O)C1=CC=CC=C1C)C2=NC(=CS2)C3=CC(OC)=CC=C3OC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.723

>  <W2 Pf proliferation inhibition EC50 uM>
2.864

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.017857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2643
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    6.1579   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -0.2211    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2079   -0.2211    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2079    1.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204    1.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    1.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.2211    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.6368    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.2243    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.0493    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    3.3513    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.0658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    4.7802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954    4.7802    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    5.4947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    4.0658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954    3.3513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
 17 18  2  0  0  0  0
 14 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 22 28  1  0  0  0  0
  3 29  1  0  0  0  0
 29 30  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  10
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2643

>  <JC_XSMILES>
COC(CNC(=O)C1=CNC2=CC=C(C=C2C1=O)S(=O)(=O)N3CCN(C)CC3)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.862

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2644
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2644

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)\C=C\C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.371

>  <W2 Pf proliferation inhibition EC50 uM>
0.2862

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2645
  Mrv1591402191617072D          

 27 30  0  0  1  0            999 V2000
    0.0962   -2.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -1.8166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -0.5791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    0.6584    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2396    1.0709    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.2396    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    2.3084    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.0915    1.7584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0915    1.2084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    0.6584    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.8959    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.3830    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    0.6584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.8959    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  6  0  0  0
  8  7  1  6  0  0  0
  8  9  1  0  0  0  0
 10  9  1  1  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 13 14  1  0  0  0  0
 15 14  1  0  0  0  0
 10 15  1  0  0  0  0
 15 16  1  1  0  0  0
 16 17  2  0  0  0  0
  7 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2645

>  <JC_XSMILES>
CCCC(=O)O[C@@H]([C@@H]1C[C@@H]2CCN1C[C@@H]2C=C)C3=CC=NC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.335

>  <W2 Pf proliferation inhibition EC50 uM>
0.2862

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009174312

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2646
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2646

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)COC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0983

>  <W2 Pf proliferation inhibition EC50 uM>
0.2862

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028037383

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2649
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -1.4289   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 19 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2649

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)S(=O)(=O)NCCCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.934

>  <W2 Pf proliferation inhibition EC50 uM>
0.2754

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.67

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-265
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -3.8062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.0215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6486   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4691   -4.3874    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3130   -5.2273    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7980   -5.8947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4624   -6.6484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9473   -7.3158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6118   -8.0695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7913   -8.1557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3064   -7.4883    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6419   -6.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-265

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2=CC(=NO2)C(=O)NCC3=CC=CN=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.29

>  <W2 Pf proliferation inhibition EC50 uM>
1.7

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2651
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -11.1375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -12.7875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -12.7875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -15.2625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
  9 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 13 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 26 32  4  0  0  0  0
  6 33  4  0  0  0  0
 33 34  4  0  0  0  0
  3 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2651

>  <JC_XSMILES>
COC1=CC=C(CCN2C(=O)CC(SC2=NC3=CC=CC=C3)C(=O)NC4=CC=CC(Cl)=C4)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
3.82

>  <W2 Pf proliferation inhibition EC50 uM>
2.845

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2652
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042    2.3236    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757    3.1306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612    3.5431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481    2.9911    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3294    3.4662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9968    2.9813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7505    3.3168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8367    4.1373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1693    4.6222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4156    4.2867    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  8 21  4  0  0  0  0
 21 22  4  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
  3 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2652

>  <JC_XSMILES>
COC1=CC=C2SC(NC3=NC(=CS3)C4=CC=CC=N4)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1182

>  <W2 Pf proliferation inhibition EC50 uM>
0.1247

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.4

>  <Powder data?>
Yes

>  <IFI value>
0.111111111

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-266
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 13 20  4  0  0  0  0
  9 21  4  0  0  0  0
  5 21  4  0  0  0  0
 21 22  4  0  0  0  0
  2 22  4  0  0  0  0
  7 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-266

>  <JC_XSMILES>
CC1=CC=C2N=C(C=C(C(=O)NC3=CC=C(Cl)C(Cl)=C3)C2=C1)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.699

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.015037594

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2661
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 13 23  4  0  0  0  0
 18 23  4  0  0  0  0
 15 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2661

>  <JC_XSMILES>
COC1=CC=CC=C1CNC(=O)C2=NN(C(=O)C3=CC=CC=C23)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.089

>  <W2 Pf proliferation inhibition EC50 uM>
2.821

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2665
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -16.0875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -16.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -17.3250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -17.7375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -18.5625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -18.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -19.8000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -20.2125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -19.8000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -18.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -21.0375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -21.4500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -22.2750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -22.6875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -22.2750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -22.6875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -21.4500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -15.2625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289  -14.8500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434  -16.0875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 22 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 25 31  4  0  0  0  0
 14 32  4  0  0  0  0
 32 33  4  0  0  0  0
 11 33  4  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  2  0  0  0  0
  7 37  4  0  0  0  0
 37 38  4  0  0  0  0
  4 38  4  0  0  0  0
M  CHG  2  34   1  35  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2665

>  <JC_XSMILES>
CC(C)C1=CC=C(NC(=O)C2=CC=C(NCCCN3CCN(CC3)C4=CC=CC(Cl)=C4)C(=C2)[N+]([O-])=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.632

>  <W2 Pf proliferation inhibition EC50 uM>
2.808

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2666
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
  6 11  4  0  0  0  0
 12 11  1  4  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 11 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2666

>  <JC_XSMILES>
COC1=CC=C(OC(C)=O)C(C=NNC(=O)C(C)OC2=CC=CC=C2Br)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
5.1

>  <W2 Pf proliferation inhibition EC50 uM>
2.801

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2667
  Mrv1591402191617072D          

 27 31  0  0  0  0            999 V2000
   -1.4411   -6.1255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6564   -5.8705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -5.0636    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2688   -4.7280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1825   -3.9075    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6244   -3.7360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0369   -4.4505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8439   -4.2789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5114   -4.7639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2650   -4.4283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3513   -3.6078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6838   -3.1229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9302   -3.4585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1765   -3.1229    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.9832   -5.1405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6977   -4.7280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6977   -3.9030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4122   -3.4905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1266   -3.9030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8411   -3.4905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5556   -3.9030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5556   -4.7280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8411   -5.1405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1266   -4.7280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4122   -5.1405    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.4122   -5.9655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6977   -6.3780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  3  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
  6 14  4  0  0  0  0
  4 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 16 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
M  CHG  1  25   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2667

>  <JC_XSMILES>
CCN1C(\SC2=C1C3=CC=CC=C3S2)=C\C4=CC=C5C=CC=CC5=[N+]4CC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0992

>  <W2 Pf proliferation inhibition EC50 uM>
0.1335

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.77

>  <Powder data?>
Yes

>  <IFI value>
0.183333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2668
  Mrv1591402191617072D          

 33 35  0  0  1  0            999 V2000
   -0.9481   -0.0662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7639    0.0567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2783   -0.5883    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0653    0.8247    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5509    1.4697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8523    2.2377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3380    2.8827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5222    2.7597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1097    3.4742    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7061    3.5971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9493    4.3855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109    3.0360    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0789    3.3374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2018    4.1532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9698    4.4546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6148    3.9402    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0927    5.2704    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2492    2.2133    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9637    1.8008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9637    0.9758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3762    0.2613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5512    0.2613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6782    2.2133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6782    3.0383    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3926    1.8008    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1071    2.2133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8216    1.8008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5361    2.2133    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8216    0.9758    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5676    1.7486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6905    0.9328    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2208    1.9917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7351    1.3467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 12 10  1  0  0  0  0
 12 13  1  6  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
 12 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 22  1  0  0  0  0
 19 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  2  0  0  0  0
 18 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
  8 32  4  0  0  0  0
 32 33  4  0  0  0  0
  5 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2668

>  <JC_XSMILES>
CC(=O)NC1=CC=C2NC(=O)[C@H](CCC(O)=O)N(C(C3CC3)C(=O)NCC(O)=O)C(=O)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.264

>  <W2 Pf proliferation inhibition EC50 uM>
0.2798

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.012345679

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-267
  Mrv1591402191617072D          

 10 10  0  0  0  0            999 V2000
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
  3 10  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-267

>  <JC_XSMILES>
CSC1=CC=C(Cl)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0839

>  <W2 Pf proliferation inhibition EC50 uM>
0.398

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.354

>  <Powder data?>
Yes

>  <IFI value>
0.061728395

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2674
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -1.4289    1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2539    0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6039    0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
  9 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 19 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2674

>  <JC_XSMILES>
FC(F)(F)COC1=NC(=NC(=N1)N2CCCCC2)N(C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>5.97

>  <W2 Pf proliferation inhibition EC50 uM>
2.786

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2675
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 19 25  1  0  0  0  0
 14 26  4  0  0  0  0
 26 27  4  0  0  0  0
 11 27  4  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  2  0  0  0  0
  7 31  4  0  0  0  0
  3 31  4  0  0  0  0
M  CHG  2  28   1  29  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2675

>  <JC_XSMILES>
COC1=CC=CC(NC(=O)C2=CC=C(NCCCN3CCC(C)CC3)C(=C2)[N+]([O-])=O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2958

>  <W2 Pf proliferation inhibition EC50 uM>
0.521

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.72

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2676
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  4 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  3 17  1  0  0  0  0
 12 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2676

>  <JC_XSMILES>
CCN1C2C=C(N)C=CC2=NC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0596

>  <W2 Pf proliferation inhibition EC50 uM>
0.2783

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2680
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -15.2625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -14.0250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -15.2625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -16.0875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -16.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -16.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -16.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -16.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 24 31  1  0  0  0  0
 20 32  4  0  0  0  0
 32 33  4  0  0  0  0
 17 33  4  0  0  0  0
 15 34  4  0  0  0  0
 34 35  4  0  0  0  0
 12 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2680

>  <JC_XSMILES>
CCN1CCN(CC1)C(=O)NC2=CC=C(CC3=CC=C(NC(=O)N4CCN(CC)CC4)C=C3)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
2.387

>  <W2 Pf proliferation inhibition EC50 uM>
1.72

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
62.01

>  <Powder data?>
Yes

>  <IFI value>
0.011235955

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2681
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  6 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
  2 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2681

>  <JC_XSMILES>
CC(NCCC(C1=CC=CC=C1)C2=CC=CC=C2O)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.119

>  <W2 Pf proliferation inhibition EC50 uM>
0.2773

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2685
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    6.2102    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2685

>  <JC_XSMILES>
COC1=CC=CC=C1CN2CCC3=C(C2)SC(=N3)N4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.454

>  <W2 Pf proliferation inhibition EC50 uM>
0.2769

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.097222222

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2687
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -7.0380    1.4652    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    2.7027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    2.7027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    1.4652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    3.1152    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7676    2.4007    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5926    3.8297    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    3.5277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    1.8777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    1.8777    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.1848    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6548   -0.6697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9097   -1.4544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7347   -1.4544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9897   -0.6697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 22 26  1  0  0  0  0
 20 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2687

>  <JC_XSMILES>
ClC1=CC=C(C=C1)S(=O)(=O)N2CCCCC2C(=O)NC(CN3CCCC3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1894

>  <W2 Pf proliferation inhibition EC50 uM>
0.514

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.61

>  <Powder data?>
Yes

>  <IFI value>
0.009708738

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2688
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.5893   -4.4621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3038   -4.0496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3038   -3.2246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0183   -4.4621    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7327   -4.0496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7327   -3.2246    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4472   -4.4621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1617   -4.0496    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1617   -3.2246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8762   -4.4621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5578   -3.9974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3742   -3.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9790   -2.6319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7673   -2.8751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9509   -3.6794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3462   -4.2405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6476   -5.0085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2351   -5.7230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4193   -5.8459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2357   -6.6503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4474   -6.8934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8426   -6.3323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0262   -5.5280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8145   -5.2848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 10 24  1  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2688

>  <JC_XSMILES>
CC(C)NC(=O)CN(C)C1C2=CC=CC=C2CCC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.38

>  <W2 Pf proliferation inhibition EC50 uM>
0.2535

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>9.18

>  <Powder data?>
No

>  <IFI value>
0.04587156

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-269
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 13 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 20 30  2  0  0  0  0
 30 31  1  0  0  0  0
 11 31  4  0  0  0  0
 31 32  4  0  0  0  0
  8 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-269

>  <JC_XSMILES>
CCCCNC(=O)C1=CC=C2CN(C3CCCCC3)C(CC(C)C4=CC=CC=C4)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.448

>  <W2 Pf proliferation inhibition EC50 uM>
8.21

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.66

>  <Powder data?>
Yes

>  <IFI value>
0.024691358

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2690
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6687   -9.1474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3339   -9.1474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  1  0  0  0  0
  7 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
  2 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 29 32  1  0  0  0  0
 32 33  2  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 32 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2690

>  <JC_XSMILES>
O=C(NC1=CC=C(NC(=O)NC2=CC=C(C=C2)C3=NCCN3)C=C1)NC4=CC=C(C=C4)C5=NCCN5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3049

>  <W2 Pf proliferation inhibition EC50 uM>
0.2758

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009090909

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2693
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2693

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC=CC(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2694

>  <W2 Pf proliferation inhibition EC50 uM>
0.2018

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.34

>  <Powder data?>
No

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2694
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 14 30  4  0  0  0  0
  9 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2694

>  <JC_XSMILES>
COC1=CC=CC(=N1)C2=CC=C(O)C(CNC3CCN(CC3)CC4=CC=CC=C4)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.376

>  <W2 Pf proliferation inhibition EC50 uM>
0.1633

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.94

>  <Powder data?>
Yes

>  <IFI value>
0.043103448

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2698
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -4.7613   -2.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9687   -2.3396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3742   -2.9117    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3650   -3.9413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5816   -2.6828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9871   -3.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1945   -3.0261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6000   -3.5981    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1927   -3.3693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3908   -2.5684    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7871   -3.9413    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5798   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7779   -2.9117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1835   -2.3396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3816   -1.5388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7871   -0.9667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9853   -0.1659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7779    0.0629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9761    0.8638    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3816    1.4358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3724   -0.5091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1742   -1.3100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7687   -1.8820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5706   -2.6828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1650   -3.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5890   -4.7422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1835   -5.3142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9853   -6.1150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1927   -6.3439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4018   -5.7718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2037   -4.9710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 22 23  4  0  0  0  0
 16 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 14 25  4  0  0  0  0
 25 26  2  0  0  0  0
 12 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 27 32  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  24
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2698

>  <JC_XSMILES>
CCN(CC)CCCNC(=S)N(CC1=CC2=CC=C(OC)C=C2NC1=O)C3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
4.03

>  <W2 Pf proliferation inhibition EC50 uM>
1.119

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
40.75

>  <Powder data?>
Yes

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2699
  Mrv1591402191617072D          

 36 41  0  0  0  0            999 V2000
    3.7083    0.5655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9633   -0.2192    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4783   -0.8866    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9633   -1.5540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7083   -2.3387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2603   -2.9518    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9013   -2.5102    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6464   -3.2948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8394   -3.4663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2874   -2.8532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4804   -3.0248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0716   -2.4117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1833   -1.6271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9903   -1.4555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5423   -2.0686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3493   -1.8971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8913   -1.7116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6058   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3202   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3202   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6058   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8913   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0347   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0347   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7492   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7492   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0347   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3202   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6058   -5.4241    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.3202   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
  7 16  1  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 30 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2699

>  <JC_XSMILES>
CN1N=C(C(=O)N2CCC3=CC=CC=C3C2)C4=C1CCC(C4)N5CCN(CC5)CC6=CC=CC(F)=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.477

>  <W2 Pf proliferation inhibition EC50 uM>
0.2196

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.02

>  <Powder data?>
No

>  <IFI value>
0.012195122

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2701
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7474   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 15 25  4  0  0  0  0
 25 26  4  0  0  0  0
 12 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2701

>  <JC_XSMILES>
CC1CCC(CC1)C(C)(C)OC2=CC=C(NC(=O)C3=CC=CC=C3)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
3.97

>  <W2 Pf proliferation inhibition EC50 uM>
1.167

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
42.75

>  <Powder data?>
Yes

>  <IFI value>
0.008333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2704
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -7.8375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  9 20  4  0  0  0  0
 20 21  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2704

>  <JC_XSMILES>
CCCCCCCSC1=C(O)C2=CC=C(Cl)C=C2NC1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1219

>  <W2 Pf proliferation inhibition EC50 uM>
0.272

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2707
  Mrv1591402191617072D          

 32 35  0  0  1  0            999 V2000
    2.9431   -2.5100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9431   -3.3350    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6576   -3.7475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3721   -3.3350    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6576   -4.5725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3251   -5.0574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0701   -5.8421    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2451   -5.8421    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9902   -5.0574    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5550   -6.5095    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.3800   -6.5095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6350   -7.2941    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.9675   -7.7790    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3001   -7.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9675   -8.6040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2531   -9.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1668   -9.8370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3599  -10.0085    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9474   -9.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4994   -8.6810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4196   -7.5491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0327   -6.9970    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5911   -8.3560    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3758   -8.6110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5473   -9.4179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3319   -9.6729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5034  -10.4798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8903  -11.0319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0619  -11.8389    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8465  -12.0938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1057  -10.7769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9342   -9.9700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
 10  7  1  1  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 12 21  1  1  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  4  0  0  0  0
 25 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2707

>  <JC_XSMILES>
COC(=O)C1=CN(N=N1)[C@H]2C[C@H](N(C2)CC3=CSC=C3)C(=O)NCC4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.713

>  <W2 Pf proliferation inhibition EC50 uM>
0.2004

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>7.38

>  <Powder data?>
No

>  <IFI value>
0.01980198

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-271
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -1.6904   -1.6839    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404   -1.6839    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7597   -2.4916    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076    1.3686    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6707    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9256    2.2518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 12  4  0  0  0  0
 12 13  4  0  0  0  0
  6 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  3  0  0  0  0
  7 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-271

>  <JC_XSMILES>
ClCC(=O)NC1=C(N2CCCC2=C1C#N)C(=O)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2981

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>74.18

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2710
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
    6.5519   -5.4229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2970   -4.6383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4900   -4.4668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2351   -3.6821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7871   -3.0690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5941   -3.2406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8490   -4.0252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5322   -2.2844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4703   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0842   -1.6713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9127   -0.8644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6272   -0.4519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2402   -1.0039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9047   -1.7576    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 19 24  4  0  0  0  0
  8 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2710

>  <JC_XSMILES>
CC1=CC=C(C=C1)C(CCNC2=NC=NC3=C2NC4=CC=CC=C34)C5=CC=CO5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.736

>  <W2 Pf proliferation inhibition EC50 uM>
0.524

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.37

>  <Powder data?>
Yes

>  <IFI value>
0.090909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2712
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  2  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 12 22  4  0  0  0  0
 22 23  4  0  0  0  0
  9 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2712

>  <JC_XSMILES>
CC1CC(=O)NN=C1C2=CC=C(NC(=O)C3=CC=CC=C3)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3048

>  <W2 Pf proliferation inhibition EC50 uM>
0.2705

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2714
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 12 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 20 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2714

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(=O)NC(C2=CC=C(C)C=C2)C3=CC(Cl)=C4C=CC=NC4=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.421

>  <W2 Pf proliferation inhibition EC50 uM>
2.702

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2716
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4618   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1118   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2716

>  <JC_XSMILES>
COC1=CC=CC2=C1OC(=O)C(=C2)C(=O)NC3=CC=CC(=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.064

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>2.372

>  <Powder data?>
No

>  <IFI value>
0.023255814

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2717
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    1.8953   -4.7852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1503   -4.0006    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5983   -3.3875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7913   -3.5590    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5433   -1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5983   -0.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7913   -0.3119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5363    0.4728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0884    1.0859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8953    0.9143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1503    0.1297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9573   -0.0418    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5093    0.5713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
  8 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  5 26  4  0  0  0  0
 17 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2717

>  <JC_XSMILES>
COC(=O)C1=C(N)N(C2=CC=CC=C2OC)C3=NC4=CC=CC=C4N=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.698

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2718
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -4.2553   -3.8380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2553   -4.6630    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9698   -5.0755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6843   -4.6630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4379   -4.9986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9900   -4.3855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5775   -3.6710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7705   -3.8425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5408   -5.0755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5408   -5.9005    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8264   -4.6630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1119   -5.0755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3974   -4.6630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3112   -3.8425    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5042   -3.6710    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0917   -4.3855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7288   -4.4717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0643   -5.2254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8848   -5.3116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3697   -4.6442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0342   -3.8905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5191   -3.2231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3396   -3.3093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6751   -4.0630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1902   -4.7304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6438   -4.9986    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  2  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 16 26  4  0  0  0  0
 13 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2718

>  <JC_XSMILES>
CN(CC1=CSC=C1)C(=O)CCC2=NN=C(CCCC3=CC=CC=C3)O2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.2698

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2719
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559   -4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309   -6.0770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6829   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0329   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
  8 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2719

>  <JC_XSMILES>
CC1=CC=C(C=C1)C(OCC(C)(C)C[N+](C)(C)C)C2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2649

>  <W2 Pf proliferation inhibition EC50 uM>
0.629

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.32

>  <Powder data?>
Yes

>  <IFI value>
0.022222222

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-272
  Mrv1591402191617072D          

 49 54  0  0  0  0            999 V2000
    1.4289   -8.2500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.0000   -8.2500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -10.7250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -11.9625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -11.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9849  -12.8980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8099  -12.8980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2224  -12.1836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8099  -11.4691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9849  -11.4691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -12.1836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599  -14.3270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3349  -14.3270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9224  -15.0414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3349  -15.7559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599  -15.7559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -15.0414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302  -15.2625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447  -14.0250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592  -16.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737  -16.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881  -16.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026  -14.8500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
  -10.7171  -15.2625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
  -10.0026  -14.0250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 19 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 19 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  2  0  0  0  0
 37 39  1  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 39 44  4  0  0  0  0
 43 45  1  0  0  0  0
 45 46  1  0  0  0  0
 45 47  2  0  0  0  0
 35 48  4  0  0  0  0
 48 49  4  0  0  0  0
 32 49  4  0  0  0  0
M  CHG  4   1  -1   2   1  45   1  46  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-272

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(=C1)C(=O)NC2=CC=C(C=C2)C(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=C(NC(=O)C6=CC=CC(=C6)[N+]([O-])=O)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.682

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2721
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -12.7875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 11 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
  8 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2721

>  <JC_XSMILES>
CCCCNC(=O)C1=CC=C(OC2CCN(CC2)CC3CCCCC3)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.639

>  <W2 Pf proliferation inhibition EC50 uM>
0.2696

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.014084507

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2722
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
  7 23  4  0  0  0  0
  5 24  4  0  0  0  0
 24 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2722

>  <JC_XSMILES>
BrC1=CC=C(NC2=NC(NCC3=CC=CO3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1955

>  <W2 Pf proliferation inhibition EC50 uM>
0.1925

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.15

>  <Powder data?>
Yes

>  <IFI value>
0.111111111

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2725
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -0.1756   -2.3048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6102   -1.6035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2203   -0.8765    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6043   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9943   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8189   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2535   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0781   -0.7735    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6108   -0.1434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3745   -0.4553    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3140   -1.2781    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -1.4747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1228   -2.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5574   -2.9030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1674   -3.6300    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3428   -3.6557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8789   -4.3380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0867   -4.1077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0610   -3.2831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8373   -3.0038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -4.3312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2120   -5.0582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4266   -4.3054    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2982   -2.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8636   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0390   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 15 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 13 24  4  0  0  0  0
 24 25  4  0  0  0  0
  7 25  4  0  0  0  0
 25 26  4  0  0  0  0
  4 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2725

>  <JC_XSMILES>
CCOC1=CC=C2N3N=NN=C3C(CN(C4CCCC4)C(C)=O)=CC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.2678

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018181818

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2726
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -3.3457   -2.3098    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6782   -1.8249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6782   -0.9999    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8936   -0.7450    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8936   -2.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6387   -2.8645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1907   -3.4776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0192   -4.2845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7337   -4.6970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3468   -4.1450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0112   -3.3913    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
  5 17  4  0  0  0  0
  2 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   3
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2726

>  <JC_XSMILES>
OC1=NN=C(SCC2=NC3=CC=CC=C3S2)N1CC4=CC=CO4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.46

>  <W2 Pf proliferation inhibition EC50 uM>
0.2675

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.040983607

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2733
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    2.0367   -1.2991    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.7512   -1.7116    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.0215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -3.8062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6486   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3130   -5.2273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4926   -5.3135    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7980   -5.8947    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4624   -6.6484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9473   -7.3158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6118   -8.0695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7913   -8.1557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3064   -7.4883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6419   -6.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8538   -4.4736    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.0215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
  6 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
  4 19  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2733

>  <JC_XSMILES>
[O-][N+](=O)C1=NN(CC(=O)NC2CCCCC2)C(Br)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.51

>  <W2 Pf proliferation inhibition EC50 uM>
2.664

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2734
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   -3.1034    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7858   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7858   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -3.5854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 18 34  4  0  0  0  0
 13 34  4  0  0  0  0
 34 35  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2734

>  <JC_XSMILES>
CC1CCN(CC1)C(=O)C2=C(C)C3=C(S2)N=CN(CC(=O)N4CCN(CC4)C5=CC=CC=N5)C3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.2662

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-274
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    0.7027   -0.3872    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1841   -1.0572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8515   -1.5422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5966   -2.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7716   -2.3268    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5166   -1.5422    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2680   -1.2872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4395   -0.4803    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8811   -1.8393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7096   -2.6462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3227   -3.1983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1073   -2.9433    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2788   -2.1364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6657   -1.5843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0815   -2.9942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5664   -3.6617    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4140   -3.4791    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.7489   -2.5093    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7361   -0.4441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4812    0.3405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0332    0.9536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8402    0.7820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0951   -0.0026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5431   -0.6157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9021   -0.1741    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.4541    0.4390    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.1570   -0.9587    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  2  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  4 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
  2 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
M  CHG  2  25   1  26  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-274

>  <JC_XSMILES>
OC1(CC(=NN1C(=O)C2=CC=NC=C2)C(F)(F)F)C3=CC=CC(=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.221

>  <W2 Pf proliferation inhibition EC50 uM>
>1.679

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2740
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    4.0859   -9.3661    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.9996   -8.5457    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.6671   -8.0607    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2459   -8.2101    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5315   -8.6226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9184   -8.0706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -7.3169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0744   -7.4031    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -6.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -6.6024    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -5.8880    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -5.1735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -5.1735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -4.4590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -4.4590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 17 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 21 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2740

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(O1)C(=O)NC2=CC=C3OC(=NC3=C2)C4=CC=CC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
5.06

>  <W2 Pf proliferation inhibition EC50 uM>
2.651

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2741
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -11.5500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
  7 30  4  0  0  0  0
 30 31  4  0  0  0  0
  4 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2741

>  <JC_XSMILES>
CN(C)C1=CC=C(\C=C\C(=O)NC(=O)C2=CC=CC=C2OC(=O)C3=CC=CC=C3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2382

>  <W2 Pf proliferation inhibition EC50 uM>
0.265

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2742
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
  6 17  4  0  0  0  0
 17 18  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2742

>  <JC_XSMILES>
CCOC(=O)C1=CNC2=C(CC)C=CC=C2C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.663

>  <W2 Pf proliferation inhibition EC50 uM>
2.65

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015873016

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2743
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2743

>  <JC_XSMILES>
OC1=CC=CC=C1C(=O)NC2=NC(=CS2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.005

>  <W2 Pf proliferation inhibition EC50 uM>
0.643

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
24.28

>  <Powder data?>
Yes

>  <IFI value>
0.097902098

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2744
  Mrv1591402191617072D          

 25 28  0  0  1  0            999 V2000
    5.8119   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975   -1.0709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -2.7209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -2.7209    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -0.2459    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.5251    0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    0.9916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8060    0.8541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8060    0.3041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -0.2459    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    0.9916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2075    1.0204    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8202    1.6912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4329    2.4197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 11 10  1  0  0  0  0
 11 12  1  6  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 10 24  4  0  0  0  0
  6 24  4  0  0  0  0
 24 25  4  0  0  0  0
  3 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2744

>  <JC_XSMILES>
COC1=CC=C2N=CC=C([C@H](O)C3CC4CCN3CC4(O)C=C)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.105

>  <W2 Pf proliferation inhibition EC50 uM>
0.2644

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2747
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
   -0.7299   -0.1885    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0154   -0.6010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6990   -0.1885    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0154   -1.4260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6990   -1.8385    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6990   -2.6635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4135   -3.0760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4135   -3.9010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6990   -4.3135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0154   -3.9010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0154   -3.0760    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6990   -5.1385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0154   -5.5510    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4135   -5.5510    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4135   -6.3760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1568   -6.7339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3404   -7.5382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8260   -8.1832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0010   -8.1832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4866   -7.5382    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6702   -6.7339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0252   -6.2195    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 15 21  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2747

>  <JC_XSMILES>
OC(=O)CSC1=CC=C(C=N1)C(=O)NC2CCCCNC2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.488

>  <W2 Pf proliferation inhibition EC50 uM>
0.2629

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.013888889

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2749
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -3.8837   -2.8414    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 17 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2749

>  <JC_XSMILES>
IC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C3=CN4C=CC=NC4=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.622

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-275
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
 10  7  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-275

>  <JC_XSMILES>
CC(C)C1=CC=C(C=C1)C=NNC(=O)C2=CC=CC=C2O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.678

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2750
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0597   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8443   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1953   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2897   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1101   -3.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5951   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0203   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5052   -3.2361    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2752   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0598   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6729   -2.0811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5014   -2.8881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1145   -3.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8991   -3.1852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0706   -2.3782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4575   -1.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
  8 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
  5 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2750

>  <JC_XSMILES>
COC(=O)C1=C(C)N(CC=C)C(=O)\C1=C/C2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.589

>  <W2 Pf proliferation inhibition EC50 uM>
0.2622

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.052631579

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2751
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 15 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 11 30  1  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2751

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(=O)N2C(C)CC(NC3=CC=C(C)C=C3)C4=CC=C(C)C=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.617

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2753
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    4.1794   -6.5718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7669   -5.8573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1794   -5.1429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7669   -4.4284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1794   -3.7139    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9998   -3.6277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1714   -2.8207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4569   -2.4082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8438   -2.9602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0368   -2.7887    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9130   -0.8764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0171    0.3498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7621    1.1344    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  3  0  0  0  0
 15 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 11 26  4  0  0  0  0
 18 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2753

>  <JC_XSMILES>
CCCCN1N=CC=C1NC2=CC(C)=C(C#N)C3=NC4=CC=CC=C4N23

>  <PF proliferation inhibition 3D7 EC50 uM>
4.42

>  <W2 Pf proliferation inhibition EC50 uM>
2.61

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.032258065

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2754
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2296   -8.6580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0366   -8.8295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4491   -8.1150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8971   -7.5019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  1  0  0  0  0
  2 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
 21 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2754

>  <JC_XSMILES>
OC(COC1=CC=CC=C1CNCCN2CCCC2)CN3CCC4=CC=CC=C4C3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.197

>  <W2 Pf proliferation inhibition EC50 uM>
1.655

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
63.42

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2757
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
   -1.1511    1.1770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4366    0.7645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4366   -0.0605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1511   -0.4730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2779   -0.4730    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2779   -1.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9923   -1.7105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9923   -2.5355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7068   -2.9480    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4213   -2.5355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4213   -1.7105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1357   -2.9480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8502   -2.5355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2779   -2.9480    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4366   -2.5355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4366   -1.7105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1511   -2.9480    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0894   -3.7707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6942   -4.3318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5100   -4.2089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9225   -3.4944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6211   -2.7264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8327   -2.4833    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  6 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 17 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2757

>  <JC_XSMILES>
CCC(C)NC1=NC(NC(C)CC)=NC(=N1)N2CCCCCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.479

>  <W2 Pf proliferation inhibition EC50 uM>
0.382

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.7

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-276
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -4.1801    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    1.1759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -0.4741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0597   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1953   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2897   -3.2361    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0203   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2752   -1.7840    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5052   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1696   -3.9898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3491   -4.0760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0136   -4.8297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4985   -5.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3190   -5.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6546   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1630   -6.2508    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6575   -6.3370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6479   -6.9182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  9  6  1  4  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 14 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-276

>  <JC_XSMILES>
COC1=CC=C(C=C1)N=C2NC(=O)C(\S2)=C/C3=CC=C(C=C3)N(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.023

>  <W2 Pf proliferation inhibition EC50 uM>
>1.678

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.034883721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2762
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1792   -2.8265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7923   -3.3785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5769   -3.1236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7484   -2.3166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1773   -2.3166    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  8 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 22 28  4  0  0  0  0
  6 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
  3 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2762

>  <JC_XSMILES>
COC1=CC=C(C2N(C(=O)C(O)=C2C(=O)C3=CC=CC=C3)C4=CC=CC(Cl)=C4)C(OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.591

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2764
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    5.1558   -4.1558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3308   -4.1558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9183   -4.8702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9183   -3.4413    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0933   -3.4413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6808   -2.7268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8558   -2.7268    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4433   -2.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8558   -1.2979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4433   -0.5834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6183   -0.5834    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2058   -1.2979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6183   -2.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0663   -2.6254    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6874   -2.2899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4410   -2.6254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1085   -2.1405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0222   -1.3200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6897   -0.8351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2686   -0.9845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6011   -1.4694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3308   -2.7268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9183   -2.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1558   -2.7268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 15 21  4  0  0  0  0
  4 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2764

>  <JC_XSMILES>
CC(C)N(CCNC1=NC=NC2=C1NC3=CC=C(C)C=C23)C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3061

>  <W2 Pf proliferation inhibition EC50 uM>
0.42

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.26

>  <Powder data?>
Yes

>  <IFI value>
0.051282051

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2765
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919    3.2065    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8989    3.0350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4509    3.6481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 18 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
 13 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
 12 30  1  0  0  0  0
 30 31  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2765

>  <JC_XSMILES>
CCOC(=O)N1CCC(CC1)N2C(NC3=CC=C(OCC)C=C3)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.58

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2766
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    3.6939    0.5501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6939   -0.2749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4084   -0.6874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4084   -1.5124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6939   -1.9249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6939   -2.7499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9794   -3.1624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1228   -1.9249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8373   -1.5124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1228   -2.7499    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8373   -3.1624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5518   -2.7499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2663   -3.1624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2663   -3.9874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0342   -4.2888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2774   -5.0771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8127   -5.7588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2774   -6.4404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9194   -7.1837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0967   -7.2454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6320   -6.5637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9900   -5.8204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4288   -5.2157    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6405   -5.4588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0357   -4.8977    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4569   -6.2631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6685   -6.5063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4850   -7.3106    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.5518   -4.3999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8373   -3.9874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 29  1  0  0  0  0
 14 29  4  0  0  0  0
 29 30  4  0  0  0  0
 11 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2766

>  <JC_XSMILES>
CCCC(CCC)C(=O)NC1=CC=C2CCC3=CC=CC=C3N(C(=O)CCCl)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.416

>  <W2 Pf proliferation inhibition EC50 uM>
2.577

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2768
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
 12 13  1  4  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  8 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
  6 25  4  0  0  0  0
 25 26  4  0  0  0  0
  3 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2768

>  <JC_XSMILES>
COC1=CC=C2N=C(NC(N)=NC(=O)NC3=CC=CC=C3)N=C(C)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.688

>  <W2 Pf proliferation inhibition EC50 uM>
0.896

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
34.84

>  <Powder data?>
Yes

>  <IFI value>
0.064516129

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2772
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9918   -7.2996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5546   -7.9993    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6044   -6.6288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2201   -6.6576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  3  0  0  0  0
 19 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 12 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  3  0  0  0  0
 24 27  1  0  0  0  0
 27 28  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2772

>  <JC_XSMILES>
CCCCOC1=CC=C(C=C1)C2C3CCCC=C3C(C#N)=C(N)C2(C#N)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
3.47

>  <W2 Pf proliferation inhibition EC50 uM>
1.479

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
57.74

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2773
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
  6 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  2  0  0  0  0
 16 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2773

>  <JC_XSMILES>
OC(=O)CC\C(C1=CC=C(Cl)C=C1)=C2\C=C(NC2=O)C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.646

>  <W2 Pf proliferation inhibition EC50 uM>
0.2561

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2774
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2398   -3.2276    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9849   -2.4430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599   -2.4430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9049   -3.2276    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1839   -5.8519    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7359   -6.4650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3234   -7.1795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5165   -7.0080    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
  2 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 27 29  1  0  0  0  0
 29 30  2  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 29 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2774

>  <JC_XSMILES>
O=C(NCCCNC(=O)NC1=CC=CC(=C1)C2=NCCN2)NC3=CC=CC(=C3)C4=NCCN4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.326

>  <W2 Pf proliferation inhibition EC50 uM>
0.256

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2775
  Mrv1591402191617072D          

 33 38  0  0  0  0            999 V2000
    1.4229   -2.4457    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4758    0.3498    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9237    0.9629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1787    1.7475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9857    1.9190    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5377    1.3059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2828    0.5213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2406    2.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0476    2.8752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3025    3.6598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1095    3.8313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6615    3.2182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4066    2.4336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5996    2.2621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6886    3.3167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8816    3.1452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3296    3.7583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5845    4.5429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3915    4.7144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9435    4.1014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
  5 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
  8 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 21 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2775

>  <JC_XSMILES>
FC1=CC=C2NC3=C(N=CN=C3C2=C1)N4CCN(CC4)C(C5=CC=CC=C5)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.438

>  <W2 Pf proliferation inhibition EC50 uM>
0.378

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.77

>  <Powder data?>
Yes

>  <IFI value>
0.14

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2776
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 13 22  4  0  0  0  0
  8 22  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  4  0  0  0  0
  3 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2776

>  <JC_XSMILES>
COC1=CC=C(NC2=CC(C)=NC(NCC3=CC=CC=C3)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1508

>  <W2 Pf proliferation inhibition EC50 uM>
0.427

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.7

>  <Powder data?>
Yes

>  <IFI value>
0.04

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2779
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
    4.3655   -8.5555    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.6356   -7.7760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4457   -7.6200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.8405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1757   -6.2168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4457   -5.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2559   -5.2814    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5259   -4.5018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3360   -4.3459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6061   -3.5664    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0660   -2.9427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2559   -3.0986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9056   -2.6309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6356   -3.4105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3655   -2.0073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5427   -1.9482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6017   -1.1253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4246   -1.1844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4162   -3.4105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6863   -2.6309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4964   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.7664   -1.6954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2263   -1.0718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4964   -0.2923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3065   -0.1363    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.8466   -0.7600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6567   -0.6041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1968   -1.2277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0070   -1.0718    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   11.9268   -2.0073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1167   -2.1632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5766   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9056   -4.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0955   -4.9696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8255   -5.7491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3655   -6.3728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0955   -7.1523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 16 19  1  0  0  0  0
 10 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 23 33  4  0  0  0  0
 27 33  4  0  0  0  0
  6 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
  5 37  4  0  0  0  0
 37 38  4  0  0  0  0
  2 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2779

>  <JC_XSMILES>
ClC1=CC=C2C(NCCN(CCNC(=O)C3CCC3)CCNC4=CC=NC5=CC(Cl)=CC=C45)=CC=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2073

>  <W2 Pf proliferation inhibition EC50 uM>
0.2551

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-278
  Mrv1591402191617072D          

 43 47  0  0  0  0            999 V2000
    8.6804    6.4152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9659    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2514    6.4152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5369    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5369    7.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2514    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9659    7.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8225    8.0652    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.2350    8.7797    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4100    7.3507    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1080    8.4777    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3935    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6791    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6791    9.3027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9646    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9646   10.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6791   10.9527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3935   10.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3935    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3935    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1080    6.8277    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6791    6.8277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6791    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9646    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2501    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2501    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9646    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5356    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5356    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8212    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8212    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    4.7652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0597    3.0428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1953    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0203    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2752    3.0428    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5052    1.5907    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.3257    1.6769    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.1696    0.8370    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 12 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
 31 34  1  0  0  0  0
 34 35  2  0  0  0  0
 34 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 36 40  4  0  0  0  0
 39 41  1  0  0  0  0
 41 42  1  0  0  0  0
 41 43  2  0  0  0  0
M  CHG  2  41   1  42  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-278

>  <JC_XSMILES>
CC1=CC=C(C=C1)S(=O)(=O)NC(CC2=CC=CC=C2)C(=O)N3CCC(CC3)C4CCN(CC4)C(=O)C5=CC=C(O5)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.908

>  <W2 Pf proliferation inhibition EC50 uM>
>1.676

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2780
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
   -4.2868   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158  -12.3750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737  -14.0250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592  -16.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737  -16.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881  -16.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026  -16.5000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026  -17.3250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881  -17.7375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881  -18.5625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026  -18.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026  -19.8000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881  -20.2125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737  -19.8000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881  -21.0375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737  -21.4500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737  -22.2750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881  -22.6875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026  -22.2750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171  -22.6875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026  -21.4500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171  -18.5625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171  -17.7375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 29 35  4  0  0  0  0
 25 36  4  0  0  0  0
 36 37  4  0  0  0  0
 22 37  4  0  0  0  0
 20 38  4  0  0  0  0
 16 38  4  0  0  0  0
 14 39  4  0  0  0  0
 39 40  4  0  0  0  0
 11 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2780

>  <JC_XSMILES>
NC1=CC=CC(=C1)C(=O)NC2=CC=C(OC3=CC=CC(OC4=CC=C(NC(=O)C5=CC=CC(N)=C5)C=C4)=C3)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.97

>  <W2 Pf proliferation inhibition EC50 uM>
2.55

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2784
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7045   -1.2547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8653    0.4014    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2522    0.9534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  6 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  4  0  0  0  0
 18 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2784

>  <JC_XSMILES>
COC1=CC=C(C=C1Cl)C(=O)NC2=NON=C2C3=CC=C(OC)C(OC)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.785

>  <W2 Pf proliferation inhibition EC50 uM>
2.535

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2786
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  1  0  0  0  0
  5 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  4 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
  2 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 31 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2786

>  <JC_XSMILES>
CC1CC(N(C(=O)C2=CC=C(Cl)C=C2Cl)C3=CC=CC=C3)C4=CC=CC=C4N1C(=O)C5=CC=C(Cl)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
2.775

>  <W2 Pf proliferation inhibition EC50 uM>
2.534

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2788
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  3 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 15 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2788

>  <JC_XSMILES>
C1CN(CCN1C2=CC=CC=N2)C3=CC(=NC(=N3)C4=CC=CC=N4)C5=CC=CC=N5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0729

>  <W2 Pf proliferation inhibition EC50 uM>
0.0767

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.03

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-279
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    0.7425   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4875   -1.6527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8465   -1.2111    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -0.4849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4211   -0.1494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    1.3099    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 12 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-279

>  <JC_XSMILES>
COC(=O)C1=C(OC)C(=O)OC12C=CC(=O)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
2.222

>  <W2 Pf proliferation inhibition EC50 uM>
0.423

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.524

>  <Powder data?>
Yes

>  <IFI value>
0.204545455

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2791
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
  5 16  4  0  0  0  0
 16 17  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2791

>  <JC_XSMILES>
CC(C)CC1=C(C)N=C2C=CC(Br)=CC2=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.73

>  <W2 Pf proliferation inhibition EC50 uM>
2.528

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2795
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   16.4328   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 16 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2795

>  <JC_XSMILES>
CCCCC(CC)C(=O)N(C)CCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.514

>  <W2 Pf proliferation inhibition EC50 uM>
0.2333

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>9.26

>  <Powder data?>
No

>  <IFI value>
0.036363636

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2796
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
M  CHG  2  24   1  25  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2796

>  <JC_XSMILES>
COC1=CC=C(C=C1NC(=O)C(C)NC2=CC=C(C=C2)N(C)C)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.343

>  <W2 Pf proliferation inhibition EC50 uM>
0.86

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
34.17

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2797
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    2.8579   -7.4250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6115   -2.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1635   -2.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7510   -1.4830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9440   -1.6545    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -2.4751    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1251    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0572   -3.0450    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -4.1249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
  9 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  8 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2797

>  <JC_XSMILES>
FC1=CC=C(C=C1)C(N(CC2=CC=CO2)C(=O)C3=CN=CC=N3)C(=O)NCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>8.94

>  <W2 Pf proliferation inhibition EC50 uM>
2.516

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2799
  Mrv1591402191617072D          

 35 39  0  0  1  0            999 V2000
   -2.0473   -0.5791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3328   -0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3328    0.6584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0473    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0473    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3328    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3328    3.1334    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    1.8959    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.8106    1.0709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    0.6584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396    1.0709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -0.5791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -1.8166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -2.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -3.0541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -3.8791    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -2.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -1.8166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771    2.9959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771    2.4459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396    1.8959    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    4.3709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 11 10  1  0  0  0  0
 11 12  1  1  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 11 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  2  0  0  0  0
 10 34  4  0  0  0  0
  6 34  4  0  0  0  0
 34 35  4  0  0  0  0
  3 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2799

>  <JC_XSMILES>
COC1=CC=C2N=CC=C([C@H](OC(=O)\C=C\C3=CC=C(Cl)C=C3)C4CC5CCN4CC5C=C)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2723

>  <W2 Pf proliferation inhibition EC50 uM>
0.2515

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2802
  Mrv1591402191617072D          

 85 85  0  0  1  0            999 V2000
   -2.4042    3.1952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6897    2.7827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6898    1.9577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9753    1.5452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2608    1.9576    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.4536    1.5451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2608    2.7826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9752    3.1952    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4537    3.1951    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1682    2.7826    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9597    3.0150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7901    2.0493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5727    1.2534    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2361    1.3552    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.8580    0.6220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3040   -0.0721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0339    0.5828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0602    1.3945    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6004    2.0179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1385    0.5732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6473   -0.0896    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8890    0.2304    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9674   -0.5908    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2953   -1.0693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3737   -1.8906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5449   -0.7266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5610    0.7090    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6785    1.5256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0710    0.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7643   -0.7054    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8876    0.1778    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.3975   -0.4707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0909   -1.2366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6008   -1.8851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2743   -1.3540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1942    0.9437    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8515    1.6942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9738    0.6738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1299   -0.1362    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5974    1.2141    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.3770    0.9442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4413    2.0242    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2430    2.2186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8123    1.6215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4755    3.0102    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    8.2772    3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9062    3.6073    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4755    4.2044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2773    4.0098    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2431    4.9960    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.8125    5.5930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6142    5.3985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1836    5.9955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8466    4.6069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4414    5.1905    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7473    4.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5976    6.0006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3772    6.2704    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9741    6.5409    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.1945    6.2711    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8879    7.0370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3979    7.6855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0713    7.1544    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7647    7.9204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2747    8.5688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9681    9.3347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0913    8.4514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5613    6.5060    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6786    5.6894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8893    6.9845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9677    7.8058    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1388    6.6419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0603    5.8206    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6006    5.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2363    5.8599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8583    6.5932    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7902    5.1659    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.0338    5.2052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4119    5.9385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1682    4.4326    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4537    4.0201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2607    4.4326    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1303    7.3510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7043    8.0575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9099    7.6208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  5  4  1  0  0  0  0
  5  6  1  6  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  9  7  1  1  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
 14 12  1  0  0  0  0
 14 15  1  1  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 22 20  1  0  0  0  0
 22 23  1  1  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 22 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 29 30  2  0  0  0  0
 31 29  1  0  0  0  0
 31 32  1  1  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
 31 36  1  0  0  0  0
 36 37  1  0  0  0  0
 36 38  1  0  0  0  0
 38 39  2  0  0  0  0
 40 38  1  0  0  0  0
 40 41  1  1  0  0  0
 40 42  1  0  0  0  0
 42 43  1  0  0  0  0
 43 44  2  0  0  0  0
 45 43  1  0  0  0  0
 45 46  1  1  0  0  0
 45 47  1  0  0  0  0
 47 48  1  0  0  0  0
 48 49  2  0  0  0  0
 50 48  1  0  0  0  0
 50 51  1  1  0  0  0
 51 52  1  0  0  0  0
 52 53  1  0  0  0  0
 52 54  1  0  0  0  0
 50 55  1  0  0  0  0
 55 56  1  0  0  0  0
 55 57  1  0  0  0  0
 57 58  2  0  0  0  0
 59 57  1  0  0  0  0
 59 60  1  0  0  0  0
 60 61  1  0  0  0  0
 61 62  2  0  0  0  0
 63 61  1  0  0  0  0
 63 64  1  1  0  0  0
 64 65  1  0  0  0  0
 65 66  1  0  0  0  0
 65 67  1  0  0  0  0
 63 68  1  0  0  0  0
 68 69  1  0  0  0  0
 68 70  1  0  0  0  0
 70 71  2  0  0  0  0
 70 72  1  0  0  0  0
 72 73  1  0  0  0  0
 73 74  1  0  0  0  0
 73 75  1  0  0  0  0
 75 76  2  0  0  0  0
 77 75  1  0  0  0  0
 77 78  1  1  0  0  0
 78 79  1  0  0  0  0
 77 80  1  0  0  0  0
 80 81  1  0  0  0  0
  9 81  1  0  0  0  0
 81 82  2  0  0  0  0
 59 83  1  1  0  0  0
 83 84  1  0  0  0  0
 83 85  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2802

>  <JC_XSMILES>
CCCC[C@@H](C)C(O)[C@@H]1N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC1=O)C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.859

>  <W2 Pf proliferation inhibition EC50 uM>
0.251

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.034482759

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2804
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    7.8933    2.5653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1920    2.1307    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2178    1.3061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9448    0.9161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9706    0.0915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2693   -0.3431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5423    0.0468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5166    0.8714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7896    1.2614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7638    2.0860    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0368    2.4760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0110    3.3006    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3355    2.0414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3613    1.2168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6601    0.7822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8963    1.0941    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3637    0.4640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7983   -0.2372    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5995   -0.0406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2295   -0.5732    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4083   -0.9642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8429   -1.6655    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4529   -2.3925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6283   -2.4182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1937   -1.7170    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2383   -3.1452    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4137   -3.1710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0237   -3.8980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8009   -3.9238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2355   -3.2225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0601   -3.2483    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8455   -2.4955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0209   -2.4698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5837   -0.9900    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1491   -0.2887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3245   -0.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1101    0.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2799    1.1137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1045    1.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391    0.4383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
 21 34  2  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 17 40  1  0  0  0  0
 35 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2804

>  <JC_XSMILES>
COC1=CC=CC=C1CNC(=O)CCC2N=C3N(C2=O)C(SCC(=O)NC4=CC=C(F)C=C4)=NC5=CC=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
5.29

>  <W2 Pf proliferation inhibition EC50 uM>
2.507

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.066666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2805
  Mrv1591402191617072D          

 39 44  0  0  0  0            999 V2000
    0.7787    4.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1367    3.9719    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9594    3.9102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4241    4.5919    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3173    3.1669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1400    3.1053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4980    2.3620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0332    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2105    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8526    2.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3912    0.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2162    0.9370    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5741    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1094    2.3620    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3968    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7548    2.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5775    2.5469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0422    1.8653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6842    1.1220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8616    1.0603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7305    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5189    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1237   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9401   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1517   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5470   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8037   -0.8703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0604   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4556   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6673   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4837   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0884    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9049    1.3395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8768    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0625   -1.3914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1610   -2.2105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4124   -2.5573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1487   -1.9526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2530   -1.2320    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
 11 34  1  0  0  0  0
 28 34  1  0  0  0  0
 30 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 35 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2805

>  <JC_XSMILES>
COC(=O)C1=CC=C(C=C1)C2N(C(=O)C3=CC=CC=C3)C4=CC=CC=C4N=C5CC(CC(O)=C25)C6=CC=CS6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.436

>  <W2 Pf proliferation inhibition EC50 uM>
0.625

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
24.96

>  <Powder data?>
Yes

>  <IFI value>
0.025

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2809
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3088   -3.6695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7938   -4.3369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6142   -4.2507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9498   -3.4970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4649   -2.8295    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6444   -2.9158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  4  0  0  0
  7  8  2  0  0  0  0
  8  9  1  4  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  5 15  1  0  0  0  0
  2 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2809

>  <JC_XSMILES>
O=C1CSC(=NN=CC2=CC=CN=C2)N1C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.494

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2810
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 21 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2810

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)S(=O)(=O)C3=CC=CC4=CC=CN=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1876

>  <W2 Pf proliferation inhibition EC50 uM>
0.2491

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.064814815

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2811
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -3.6020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.1730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8756   -3.6020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7006   -2.1730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 33 36  1  0  0  0  0
 36 37  1  0  0  0  0
 36 38  2  0  0  0  0
 36 39  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2811

>  <JC_XSMILES>
CC1=CC=C(C=C1)S(=O)(=O)NN2C(=O)C3=CC=CC=C3N=C2SCC(=O)NCCC4=CC=C(C=C4)S(N)(=O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.488

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2812
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    7.4432    2.0548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1883    1.2701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3813    1.0986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.3140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.1425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0223    1.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8293    1.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2812

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=CC3=C(N=N2)C4=CC=CC=C4C3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
3.84

>  <W2 Pf proliferation inhibition EC50 uM>
1.638

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
65.85

>  <Powder data?>
Yes

>  <IFI value>
0.08045977

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2813
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
   -1.0409    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2784    2.1599    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5159    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7534    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5159    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5159    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2784    0.7310    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -2.7631    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5804   -0.3960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2949   -0.8085    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1679   -1.1104    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9929    0.3185    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1515    0.4290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4370    0.8415    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7390   -0.2854    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5640    1.1435    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 16 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 21 26  4  0  0  0  0
 15 26  4  0  0  0  0
 13 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
 13 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
 31 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2813

>  <JC_XSMILES>
CCOC1=CC=CC=C1C(=O)NC(NC2=C(C(N)=O)C3=C(CCCC3)S2)(C(F)(F)F)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
>7.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.487

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2817
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 19 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2817

>  <JC_XSMILES>
COC1=CC(OC)=CC(=C1)C(=O)N(C)CCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1427

>  <W2 Pf proliferation inhibition EC50 uM>
0.1164

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.7

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2818
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -6.4137    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -5.6992    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -7.2387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0107   -6.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 22  1  0  0  0  0
  3 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
  2 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  23
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2818

>  <JC_XSMILES>
CC1=C(CN2CCC(CC2)N3CCC(CC3)C(=O)NC4CC4)NC5=C(Cl)C=CC=C15

>  <PF proliferation inhibition 3D7 EC50 uM>
0.345

>  <W2 Pf proliferation inhibition EC50 uM>
1.396

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
56.47

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-282
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    3.9996   -7.7567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7141   -8.1692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4286   -7.7567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1430   -8.1692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8575   -7.7567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8575   -6.9317    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5720   -8.1692    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.2865   -7.7567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2865   -6.9317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0009   -6.5192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7154   -6.9317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7154   -7.7567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0009   -8.1692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0009   -8.9942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6684   -9.4791    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.4134  -10.2638    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.8984  -10.9312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5628  -11.6849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7423  -11.7711    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0477  -12.3523    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.8682  -12.2661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2038  -11.5124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0242  -11.4262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5092  -12.0936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3296  -12.0074    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.8146  -12.6748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4790  -13.4285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6585  -13.5147    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1736  -12.8473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3531  -12.9335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5884  -10.2638    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3335   -9.4791    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 21 30  4  0  0  0  0
 16 31  4  0  0  0  0
 31 32  4  0  0  0  0
 14 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-282

>  <JC_XSMILES>
CCCCC(=O)NC1=CC=CC=C1C2=NN(CC(=O)NC3=CC=C4OCCOC4=C3)N=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.138

>  <W2 Pf proliferation inhibition EC50 uM>
>1.666

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2826
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
 13 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2826

>  <JC_XSMILES>
CN1CCN(CC1)NC2=CC=NC3=CC4=CC=CC=C4C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1044

>  <W2 Pf proliferation inhibition EC50 uM>
0.246

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2827
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3033   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  3 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2827

>  <JC_XSMILES>
CCN(C1=CC=CC=C1)S(=O)(=O)C2=CC=C(F)C(=C2)C(=O)NC3=C(C)C=CC=C3C

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.454

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2828
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 23 30  1  0  0  0  0
 12 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 36 37  4  0  0  0  0
 10 37  4  0  0  0  0
 37 38  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2828

>  <JC_XSMILES>
COC1=CC=C(C=C1Cl)N2N=C(C(=O)NCC(=O)NCCCN3CC(C)CC(C)C3)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>7.36

>  <W2 Pf proliferation inhibition EC50 uM>
1.873

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
76.36

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2829
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1773   -2.3166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  2  0  0  0  0
  3  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2829

>  <JC_XSMILES>
CN1C(SCC(C)=O)=NN=C1C2=CC=NC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.3103

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>12.66

>  <Powder data?>
No

>  <IFI value>
0.015151515

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2830
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    1.4291    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3790    0.3412    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6498    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1433   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8578    0.0002    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8578    0.8252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -2.4749    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -4.1249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 13 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2830

>  <JC_XSMILES>
COC(=O)C1=CNC=C(C1C2=CC(OC)=C(OC)C=C2OC)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.354

>  <W2 Pf proliferation inhibition EC50 uM>
0.2449

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.048780488

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2832
  Mrv1591402191617072D          

 32 35  0  0  1  0            999 V2000
    0.4889   -5.3951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0631   -4.7820    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1918   -3.9974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3602   -3.3843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1053   -2.5997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7017   -2.4282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2537   -3.0413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9988   -3.8259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9566   -1.6436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4717   -0.9761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9566   -0.3087    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7017    0.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2537    1.0890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0607    0.9175    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9988    1.8737    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5508    2.4868    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.3578    2.3152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9098    2.9283    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7168    2.7568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6549    3.7129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8479    3.8845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2959    3.2714    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.4889    3.4429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0631    2.8298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2340    4.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7413   -0.5636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3863   -0.0492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1906   -0.2328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5485   -0.9761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1906   -1.7194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3863   -1.9030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7413   -1.3886    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 16 15  1  6  0  0  0
 16 17  1  0  0  0  0
 18 17  1  0  0  0  0
 18 19  1  1  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 22 21  1  0  0  0  0
 16 22  1  0  0  0  0
 22 23  1  1  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 11 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
  9 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  CHG  1  11   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2832

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C[N+](CC(=O)O[C@H]3C[C@H](C)CC[C@@H]3C(C)C)=C4CCCCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.45

>  <W2 Pf proliferation inhibition EC50 uM>
0.404

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.52

>  <Powder data?>
Yes

>  <IFI value>
0.218487395

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2835
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
   -2.1900   -7.0807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3650   -7.0807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9525   -7.7952    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.1275   -7.7952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2850   -8.5097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1275   -9.2241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9525   -9.2241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3650   -9.9386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1900   -9.9386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6025   -9.2241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1900   -8.5097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3650   -8.5097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2850   -7.0807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1100   -7.0807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5225   -6.3663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3475   -6.3663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7600   -7.0807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3475   -7.7952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1228   -8.0774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2043   -8.6077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5225   -7.7952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7600   -5.6518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5850   -5.6518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0700   -4.9843    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8150   -4.1997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3671   -3.5866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8546   -5.2393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5691   -4.8268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2835   -5.2393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2835   -6.0643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5691   -6.4768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8546   -6.0643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0700   -6.3192    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  3 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 14 21  1  0  0  0  0
 16 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  1  0  0  0  0
 23 33  1  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2835

>  <JC_XSMILES>
CCN1C(\C=CC2=CC=CC=C12)=C\C3=CC(\CC(C)(C)C3)=C\C4=[N+](CC)C5=CC=CC=C5S4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.486

>  <W2 Pf proliferation inhibition EC50 uM>
1.031

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
42.24

>  <Powder data?>
Yes

>  <IFI value>
0.094339623

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2836
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 20 27  1  0  0  0  0
 13 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 33 34  4  0  0  0  0
 11 34  4  0  0  0  0
 34 35  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2836

>  <JC_XSMILES>
COC1=CC(OC)=CC(=C1)N2N=C(C(=O)NCCCN3CC(C)CC(C)C3)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.436

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2837
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
  5 14  1  0  0  0  0
 10 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 25 26  4  0  0  0  0
 19 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2837

>  <JC_XSMILES>
CCCCN1CC2=CC=C(C=C2N=C1)C(=O)NCC3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.463

>  <W2 Pf proliferation inhibition EC50 uM>
0.2433

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.012048193

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2838
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.0342   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6842   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 16 30  4  0  0  0  0
 30 31  4  0  0  0  0
 13 31  4  0  0  0  0
 30 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 35 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2838

>  <JC_XSMILES>
COC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(N3CCC(CC3)CC4=CC=CC=C4)C(=C2)C(=O)NC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
2.118

>  <W2 Pf proliferation inhibition EC50 uM>
2.427

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.020833333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2839
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    6.4302    3.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.0536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.2286    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3832    1.7437    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283    0.9590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3033    0.9590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8183    0.2916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9979    0.3778    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5129   -0.2896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6925   -0.2034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3569    0.5503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8418    1.2177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6623    1.1315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5364    0.6365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0515   -0.0309    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2009    1.3902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3804    1.4764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045    0.8090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9250    0.8952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2606    1.6489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7757    2.3164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0448    2.2301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5297    2.8976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1942    3.6512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6791    4.3187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4996    4.2324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8352    3.4788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6556    3.3925    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9912    2.6389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3502    2.8113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0483    1.7437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2637    1.9986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 23 30  4  0  0  0  0
  6 31  4  0  0  0  0
  3 31  4  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2839

>  <JC_XSMILES>
CCN1N=CC(CN2CCC(CC2)C(=O)NC3=CC=CC=C3C4=CC=CC(OC)=C4)=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.155

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
47.61

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2842
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    7.1883    3.6037    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6242    3.0016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8637    2.2121    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8208    3.1890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2568    2.5869    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4962    1.7974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9322    1.1953    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1288    1.3827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8894    2.1722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0645    2.1885    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4068    2.6864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7299    2.2148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9693    1.4253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7942    1.4090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4519    0.9110    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4534    2.7743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2139    3.5638    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  4  0  0  0  0
 14 15  4  0  0  0  0
  8 15  4  0  0  0  0
  9 16  4  0  0  0  0
  5 16  4  0  0  0  0
 16 17  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2842

>  <JC_XSMILES>
OC(=O)CN1C=NC2=C(N3CCCC3=N2)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>10.42

>  <W2 Pf proliferation inhibition EC50 uM>
2.419

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2848
  Mrv1591402191617072D          

 60 62  0  0  1  0            999 V2000
   -4.1486   -0.7315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6183   -0.0996    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9004    0.6757    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.4307    0.0437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2432    0.1871    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5253    0.9623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9950    1.5943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1825    1.4510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2771    2.3695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7467    3.0015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9343    2.8582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0289    3.7768    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -5.8413    3.9201    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4985    4.4087    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -4.7806    5.1840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6861    4.2654    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.4039    3.4901    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1557    4.8973    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.4378    5.6726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3433    4.7540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0611    3.9788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2487    3.8355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5915    3.3468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3094    2.5716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4969    2.4282    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2148    1.6530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8397    1.9396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6522    2.0829    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5576    1.1643    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0879    0.5324    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.8058   -0.2429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3362   -0.8748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9934   -0.3862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4630    0.2458    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7113   -1.1615    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.8988   -1.3048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2416   -1.7934    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.7719   -1.1614    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5272   -2.2060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5272   -3.0310    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.8128   -3.4435    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8128   -4.2685    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0984   -4.6811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0984   -5.5061    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.6160   -5.9186    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8129   -5.9185    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.8130   -6.7435    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5275   -7.1560    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5275   -7.9810    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2419   -6.7434    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5274   -5.5060    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.2419   -5.9184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5273   -4.6810    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2417   -3.4434    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.2418   -4.2684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9562   -3.0309    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.9561   -2.2059    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6707   -3.4433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6707   -4.2683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3852   -4.6808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  6  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  4  0  0  0
  6  7  2  0  0  0  0
  7  8  1  4  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 10  1  0  0  0  0
 12 13  1  6  0  0  0
 12 14  1  0  0  0  0
 14 15  1  6  0  0  0
 14 16  1  0  0  0  0
 16 17  1  1  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  4  0  0  0
 23 21  1  4  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 30 29  1  0  0  0  0
 30  3  1  0  0  0  0
 30 31  1  6  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 35 33  1  0  0  0  0
 35 36  1  6  0  0  0
 35 37  1  0  0  0  0
 37 38  1  6  0  0  0
 37 39  1  0  0  0  0
 40 39  1  0  0  0  0
 40 41  1  1  0  0  0
 42 41  1  1  0  0  0
 42 43  1  0  0  0  0
 44 43  1  0  0  0  0
 44 45  1  1  0  0  0
 46 44  1  0  0  0  0
 46 47  1  6  0  0  0
 47 48  1  0  0  0  0
 48 49  1  0  0  0  0
 48 50  2  0  0  0  0
 46 51  1  0  0  0  0
 51 52  1  1  0  0  0
 51 53  1  0  0  0  0
 42 53  1  0  0  0  0
 54 40  1  0  0  0  0
 54 55  1  6  0  0  0
 54 56  1  0  0  0  0
 56 57  1  0  0  0  0
 37 57  1  1  0  0  0
 56 58  1  1  0  0  0
 58 59  2  0  0  0  0
 59 60  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2848

>  <JC_XSMILES>
CO[C@H]1C=CC=C(C)CC(C)[C@H](O)[C@H](C)[C@H](O)[C@H](C)C=C(C)C=C(OC)C(=O)O[C@@H]1C(C)C(O)[C@H](C)[C@@]2(O)C[C@@H](O[C@H]3C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O3)[C@H](C)[C@H](O2)\C=C\C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.672

>  <W2 Pf proliferation inhibition EC50 uM>
0.2401

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.155172414

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2849
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
   -2.1434   10.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    9.2411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.9411    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674    4.2187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    4.2187    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
  8 17  4  0  0  0  0
 17 18  4  0  0  0  0
  5 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2849

>  <JC_XSMILES>
CCCOC1=CC=C(NC(=O)C2=CC=CO2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.146

>  <W2 Pf proliferation inhibition EC50 uM>
0.406

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.93

>  <Powder data?>
Yes

>  <IFI value>
0.060606061

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2852
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    2.0626    2.6554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8872    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3218    1.9800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9318    1.2530    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3664    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1910    0.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6256   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4502   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8849   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4949   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6703   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2357   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4111   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8784   -1.5066    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1147   -1.1947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4134   -1.6293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6864   -1.2393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4392   -2.4539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1752   -0.3719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5452    0.1607    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9765   -0.1753    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1464    2.0057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5810    1.3045    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5364    2.7327    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1018    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2772    3.4082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8426    4.1095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2326    4.8365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0572    4.8622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4472    5.5892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4918    4.1610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 15 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
  5 21  4  0  0  0  0
 13 21  4  0  0  0  0
  3 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 25 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2852

>  <JC_XSMILES>
CCC(SC1=NC2=CC=CC=C2C3=NC(C(C)C)C(=O)N13)C(=O)NC4=CC=CC(C)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
7.02

>  <W2 Pf proliferation inhibition EC50 uM>
2.395

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2854
  Mrv1591402191617072D          

 47 51  0  0  0  0            999 V2000
    2.9635   -6.0316    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6671   -6.8016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8522   -6.9299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3336   -6.2883    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6299   -5.5184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1113   -4.8767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2963   -5.0051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2223   -4.3634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0741   -3.5935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8890   -3.4652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4077   -4.1068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5186   -6.4166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2223   -7.1866    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8150   -5.9033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3336   -5.2617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1485   -5.3900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6671   -4.7484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3708   -3.9785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5558   -3.8502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0372   -4.4918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1113   -6.6733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5927   -7.3149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8890   -8.0848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7040   -8.2131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2226   -7.5715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9263   -6.8016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1857   -7.4432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0007   -7.3149    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5193   -7.9565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3343   -7.8282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8529   -8.4698    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6678   -8.3415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1865   -8.9831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8901   -9.7530    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0751   -9.8813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5565   -9.2397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2971   -6.5449    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5271   -6.2486    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0670   -6.8413    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5934   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4084   -5.6467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7047   -4.8767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5197   -4.7484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0383   -5.3900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7419   -6.1600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9270   -6.2883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
  2 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 32 37  1  0  0  0  0
 29 38  1  0  0  0  0
 38 39  2  0  0  0  0
 38 40  2  0  0  0  0
 38 41  1  0  0  0  0
 41 42  1  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 42 47  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2854

>  <JC_XSMILES>
OC(CN(CC1=CC=CC=C1)C(=O)NC(C2=CC=CC=C2)C3=CC=CC=C3)CN(CCN4CCOCC4)S(=O)(=O)CC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.115

>  <W2 Pf proliferation inhibition EC50 uM>
0.1624

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.82

>  <Powder data?>
No

>  <IFI value>
0.019417476

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2857
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 13 22  4  0  0  0  0
 17 22  4  0  0  0  0
 11 23  4  0  0  0  0
 23 24  4  0  0  0  0
  8 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2857

>  <JC_XSMILES>
CN1CCN(CC1)C2=CC=C(NC3=CC=NC4=CC=CC=C34)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2202

>  <W2 Pf proliferation inhibition EC50 uM>
0.2373

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2865
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -12.7875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
 10  7  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2865

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)N=CC2=CC=C(C=C2)N3CCOCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1748

>  <W2 Pf proliferation inhibition EC50 uM>
0.2354

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2866
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -3.0646   -3.9516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0646   -4.7766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3971   -5.2615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6125   -5.0066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4410   -4.1996    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0541   -3.6476    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8825   -2.8406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0979   -2.5856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4852   -1.8572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3097   -1.8284    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4478   -2.0777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5626   -1.2608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0875   -0.7528    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0273    0.0641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7923    0.3732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9071    1.1902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2570    1.6981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5080    1.3890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6228    0.5721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4848   -3.1377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6564   -3.9446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6521   -6.0461    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4771   -6.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7320   -5.2615    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9620   -6.7136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7070   -7.4982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3745   -7.9831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0419   -7.4982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7870   -6.7136    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
  8 20  1  0  0  0  0
 20 21  1  0  0  0  0
  5 21  1  0  0  0  0
  3 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2866

>  <JC_XSMILES>
CC1=C(CN2CCC(CO)(CCOC3=CC=CC=C3)CC2)N=C(O1)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
8.47

>  <W2 Pf proliferation inhibition EC50 uM>
2.352

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2869
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
    3.5724   13.3661    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   12.9536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   12.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   11.7161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   10.8911    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   10.8911    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    6.7661    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.7661    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.2911    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.9812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.9812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   12.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   12.9536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   13.3661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   14.1911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   14.6760    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   15.4606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   15.4606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   14.6760    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 17 23  4  0  0  0  0
 20 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 24 28  1  0  0  0  0
  4 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
  2 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  2  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 32 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2869

>  <JC_XSMILES>
ClC1=CC(NC(=O)C2=CC=C(C=C2)C(=O)NC3=CC=C(C(Cl)=C3)C4=NCCN4)=CC=C1C5=NCCN5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.554

>  <W2 Pf proliferation inhibition EC50 uM>
0.2341

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2876
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.5882   -6.3604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3027   -6.7729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0172   -6.3604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7316   -6.7729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4461   -6.3604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1606   -6.7729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8750   -6.3604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5895   -6.7729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5895   -7.5979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3040   -8.0104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3040   -8.8354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0185   -9.2479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0185  -10.0729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7721   -9.7373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3242  -10.3504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9117  -11.0649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1047  -10.8934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3040  -10.4854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5895  -10.0729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8750  -10.4854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5895   -9.2479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8750   -8.0104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1606   -7.5979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 11 21  1  0  0  0  0
  9 22  4  0  0  0  0
 22 23  4  0  0  0  0
  6 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2876

>  <JC_XSMILES>
CCCCOC1=CC=C(NC2=NC3(CCCC3)NC(N)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.086

>  <W2 Pf proliferation inhibition EC50 uM>
2.332

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2877
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0468   -4.1831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0468   -3.3581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4757   -4.1831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4757   -3.3581    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1902   -4.5956    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9047   -4.1831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9909   -3.3626    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7979   -3.1911    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2104   -3.9056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6583   -4.5187    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0309   -3.9918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5158   -3.3244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3363   -3.4106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6718   -4.1643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4923   -4.2505    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    7.1869   -4.8317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3664   -4.7455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2877

>  <JC_XSMILES>
CC(C)CC(=O)NC1=NN=C(S1)C2=CC=C(Br)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.04

>  <W2 Pf proliferation inhibition EC50 uM>
2.331

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2880
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    7.4432   -1.2298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8912   -1.8429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0842   -1.6713    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5322   -2.2844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4703   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0223   -0.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8293   -0.8867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896    1.6387    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.1966    1.4672    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.1347    2.4233    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 10 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
M  CHG  2  23   1  24  -1
M  STY  1   1 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2880

>  <JC_XSMILES>
CCN1CCC(CC1)NC2CCCC3=C2NC4=CC=C(C=C34)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.497

>  <W2 Pf proliferation inhibition EC50 uM>
0.337

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.54

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2885
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    3.3882   -1.8430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3276   -1.8430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8612   -4.4877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3309   -3.5692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  2 10  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2885

>  <JC_XSMILES>
CC1(C)CC(CC(C)(C)N1)NC(=O)CC2=CC=C(Cl)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.304

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2887
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    1.8787    4.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1337    3.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9406    3.3795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1956    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435    1.9817    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366    2.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5816    2.9379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 14 20  1  0  0  0  0
 15 21  4  0  0  0  0
 12 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2887

>  <JC_XSMILES>
CC1CCN(CC1)C2=NC=NC3=C2C4=C(CC(C)CC4)S3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.051

>  <W2 Pf proliferation inhibition EC50 uM>
2.304

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2888
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
   -5.5316    1.8036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8642    1.3187    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1105    1.6542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4431    1.1693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5293    0.3488    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2830    0.0133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9504    0.4982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8619   -0.1361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1082    0.1995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4407   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6561   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4012    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6561   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4407   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1082   -1.5954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0219   -2.4158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6894   -2.9008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4431   -2.5652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5293   -1.7447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8619   -1.2598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  8  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 13 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 22 30  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2888

>  <JC_XSMILES>
CN1CCN(CC1)NC=C2C(=O)N(N=C2C3=CC=CC=C3)C4=NC5=CC=CC=C5S4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.303

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2892
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2892

>  <JC_XSMILES>
COC1=CC=C(NC2=CC=CC=C2NC(=O)C3=CC=CC(=C3)N(C)C)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.447

>  <W2 Pf proliferation inhibition EC50 uM>
2.291

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2893
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -6.7105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -8.1395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
  7 22  4  0  0  0  0
 22 23  4  0  0  0  0
  4 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2893

>  <JC_XSMILES>
CN(C)C1=CC=C(NC(=O)NS(=O)(=O)C2=CC=C(C)C=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.324

>  <W2 Pf proliferation inhibition EC50 uM>
0.467

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.41

>  <Powder data?>
Yes

>  <IFI value>
0.032

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2894
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    6.8513    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
  8 18  4  0  0  0  0
 13 18  4  0  0  0  0
  4 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2894

>  <JC_XSMILES>
CC1=CC(CCNC2=CC(C)=NC3=NC(C)=NN23)=CC=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.417

>  <W2 Pf proliferation inhibition EC50 uM>
2.288

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2899
  Mrv1591402191617072D          

 46 51  0  0  0  0            999 V2000
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5517    3.0153    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9234    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042    0.7222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9562    1.3353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -0.0848    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612   -0.4973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7750   -1.3178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481    0.0548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3294   -0.4203    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4156   -1.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1693   -1.5764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8367   -1.0915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5904   -1.4270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7505   -0.2710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9968    0.0646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1903    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9234    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9234    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9234    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    4.8229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  4  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 13 19  4  0  0  0  0
 16 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 11 27  4  0  0  0  0
 27 28  2  0  0  0  0
 27 29  4  0  0  0  0
  9 29  4  0  0  0  0
 29 30  1  0  0  0  0
  6 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 35 38  4  0  0  0  0
 31 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
  7 41  1  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 41 46  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2899

>  <JC_XSMILES>
CCOC(=O)C1=C(N=c2sc(=CC3=C(C)N(C(C)=C3)C4=CC=C(F)C=C4)c(=O)n2C1C5=CC=CC(OC)=C5OC)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
2.325

>  <W2 Pf proliferation inhibition EC50 uM>
2.28

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024096386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-290
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    4.2868    6.6000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4618    5.7750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1118    5.7750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  2  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 14 29  4  0  0  0  0
 23 29  4  0  0  0  0
  9 30  4  0  0  0  0
  5 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-290

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(NC(=O)CN2C3=CC=CC=C3C(=O)C4=CC(Cl)=CC=C24)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.36

>  <W2 Pf proliferation inhibition EC50 uM>
1.649

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.034482759

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2901
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    5.4957    3.9979    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6707    3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.3207    3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2901

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC=C1CN2CCC3=C(C2)SC(=N3)N4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2529

>  <W2 Pf proliferation inhibition EC50 uM>
0.2278

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.098591549

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2902
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2902

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1414

>  <W2 Pf proliferation inhibition EC50 uM>
0.1223

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.37

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2903
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 10 17  4  0  0  0  0
  5 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2903

>  <JC_XSMILES>
ClC1=CC=C(NC(=O)NC2=CC=C(Cl)C(Cl)=C2)C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
1.028

>  <W2 Pf proliferation inhibition EC50 uM>
0.46

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.22

>  <Powder data?>
Yes

>  <IFI value>
0.060606061

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2905
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -0.2934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
 14 18  4  0  0  0  0
  7 19  4  0  0  0  0
 19 20  4  0  0  0  0
  4 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2905

>  <JC_XSMILES>
CN(C)C1=CC=C(NC2=CC(C)=NC3=NC=NN23)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
6

>  <W2 Pf proliferation inhibition EC50 uM>
2.27

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2908
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
 12 13  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 12 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2908

>  <JC_XSMILES>
COC(=O)C1=C(C)N(C)C(C)=C(C1C2=CC=C(C=C2)[N+]([O-])=O)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.633

>  <W2 Pf proliferation inhibition EC50 uM>
2.261

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2910
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
    1.1809   -3.5477    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  6 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  4 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2910

>  <JC_XSMILES>
OCCC1=CN(C2=CC=CC=C2)C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.717

>  <W2 Pf proliferation inhibition EC50 uM>
0.2256

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2911
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    4.9675    0.9963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9675    0.1713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6820   -0.2412    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2531   -0.2412    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2531   -1.0662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9205   -1.5511    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6656   -2.3357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1505   -3.0031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8406   -2.3357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5856   -1.5511    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3556   -3.0031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6106   -3.7878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9431   -4.2727    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2757   -3.7878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4911   -4.0427    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -3.4907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0934   -3.7456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5197   -3.1936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3482   -2.3866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9613   -1.8346    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.4364   -2.1317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0495   -2.6837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5306   -3.0031    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 14 23  4  0  0  0  0
 11 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2911

>  <JC_XSMILES>
CC(=O)NC1=NC(C)=C(S1)C2=CSC(NC3=CC=C(Br)C=C3)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.696

>  <W2 Pf proliferation inhibition EC50 uM>
0.859

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
38.09

>  <Powder data?>
Yes

>  <IFI value>
0.048076923

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2912
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 11 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2912

>  <JC_XSMILES>
OC1=CC=C(Cl)C=C1C2CC(=NC(N2)C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.813

>  <W2 Pf proliferation inhibition EC50 uM>
0.783

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
34.73

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2913
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -1.1439   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0936   -3.8913    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.9186   -3.8913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3311   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9186   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0936   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -6.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1439   -6.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5564   -6.7491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3814   -6.7491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7939   -7.4636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7939   -6.0347    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5564   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1439   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3311   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1561   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6410   -2.5093    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3861   -1.7247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9381   -1.1116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4256   -2.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1401   -2.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8546   -2.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8546   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1401   -4.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4256   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6410   -3.8442    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  3 16  4  0  0  0  0
  7 16  4  0  0  0  0
  4 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 18 28  1  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2913

>  <JC_XSMILES>
CCN1C(\C=CC2=CC(NC(C)=O)=CC=C12)=C\C3=[N+](CC)C4=CC=CC=C4S3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2553

>  <W2 Pf proliferation inhibition EC50 uM>
0.2254

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2914
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
   -7.3673   -2.0869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5468   -2.0007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2112   -1.2470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3907   -1.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9058   -1.8282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2414   -2.5819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0619   -2.6681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0853   -1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6728   -1.0275    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8659   -1.1990    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0652   -2.4320    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -2.4320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0783   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7927   -2.4320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7927   -3.2570    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5072   -2.0195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2217   -2.4320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9361   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6506   -2.4320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3651   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0796   -2.4320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0796   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3651   -3.6695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6506   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2217   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9361   -3.6695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9361   -4.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2217   -4.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5072   -4.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5072   -3.6695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5333   -2.3551    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7048   -3.1620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0917   -3.7141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2633   -4.5211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0479   -4.7760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6610   -4.2240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4456   -4.4789    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -4.4894   -3.4170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 19 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 11 33  4  0  0  0  0
  8 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  1  0  0  0  0
 38 40  4  0  0  0  0
 34 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2914

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=NN=C(SCCCC(=O)NC(CC3=CC=CC=C3)C4=CC=CC=C4)N2C5=CC=CC(Cl)=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.621

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>27.57

>  <Powder data?>
Yes

>  <IFI value>
0.042105263

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2915
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.5763   -4.1479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2907   -4.5604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2907   -5.3854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0052   -4.1479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7197   -4.5604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4342   -4.1479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1486   -4.5604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1486   -5.3854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8631   -5.7979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5776   -5.3854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5776   -4.5604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8631   -4.1479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0346   -3.3410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8551   -3.2547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3400   -2.5873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1605   -2.6735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4961   -3.4272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3165   -3.5134    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    7.0111   -4.0946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1907   -4.0084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 14 20  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  13
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2915

>  <JC_XSMILES>
CN(C)CCNC1=NC=NC2=C1NC3=CC=C(Br)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1002

>  <W2 Pf proliferation inhibition EC50 uM>
0.476

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.14

>  <Powder data?>
Yes

>  <IFI value>
0.137254902

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2916
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
   -0.0957    2.4393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.5952    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9845    3.3748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4444    3.9984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.7780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5246    4.9339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0647    4.3103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7946    3.5307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3347    2.9071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0647    2.1275    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6048    1.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4149    1.6598    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3347    0.7243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8748    0.1007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6048   -0.6789    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1449   -1.3025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9550   -1.1466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2251   -0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0352   -0.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3052    0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7651    1.1921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9550    1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6850    0.2566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7946   -0.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5246   -1.6143    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2546   -0.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4444   -0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0957    0.2566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1744    1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9845    1.1921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5246    0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 14 23  1  0  0  0  0
 18 23  4  0  0  0  0
 15 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 13 31  1  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2916

>  <JC_XSMILES>
COC1=CC=CC=C1CNC(=O)C2C3N(CCC4=CC=CC=C34)C(=O)C5=CC=CC=C25

>  <PF proliferation inhibition 3D7 EC50 uM>
4.9

>  <W2 Pf proliferation inhibition EC50 uM>
2.249

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2918
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2918

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2032

>  <W2 Pf proliferation inhibition EC50 uM>
0.2246

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2919
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  6 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2919

>  <JC_XSMILES>
BrC1=CC=CC(CNC2CCN(CC2)CCC3=CC=CC=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.31

>  <W2 Pf proliferation inhibition EC50 uM>
0.515

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
22.93

>  <Powder data?>
Yes

>  <IFI value>
0.023622047

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-292
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    1.1355    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0098   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -2.3744    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7403   -2.1195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7403   -1.2945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  7 15  4  0  0  0  0
 11 15  4  0  0  0  0
 12 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
  5 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
  3 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-292

>  <JC_XSMILES>
COC1=CC(NC2=NC=CN3C(=CN=C23)C4=CSC=C4)=CC(OC)=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.648

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2920
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -7.7525    9.3027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525    8.4777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    8.4777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    7.2402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380    7.2402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    5.5902    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    2.2902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    2.2902    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2272    0.5678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4821   -0.2169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3071   -0.2169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5620    0.5678    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4669    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4669    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
 16 25  4  0  0  0  0
 25 26  4  0  0  0  0
 13 26  4  0  0  0  0
 11 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2920

>  <JC_XSMILES>
COC1=CC(OC)=NC(=N1)C(SC2=CC=C(NC(=O)C3=CC=CS3)C=C2)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.175

>  <W2 Pf proliferation inhibition EC50 uM>
0.2245

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.007874016

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2924
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 25 26  4  0  0  0  0
 19 26  4  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  2  0  0  0  0
 15 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 13 32  4  0  0  0  0
 32 33  4  0  0  0  0
  9 33  4  0  0  0  0
M  CHG  2  27   1  28  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2924

>  <JC_XSMILES>
CCN1CCN(CC1)C2=CC(C)=C3C=C(NC(=O)C4=CC=C(OC)C(=C4)[N+]([O-])=O)C=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.273

>  <W2 Pf proliferation inhibition EC50 uM>
0.344

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.36

>  <Powder data?>
Yes

>  <IFI value>
0.114754098

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2925
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -1.5241   -2.8772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6995   -2.9030    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2649   -2.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5597   -2.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9943   -1.5262    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6043   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0390   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8636   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2982    0.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1228    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -0.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3140   -0.3719    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3745   -1.1947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6108   -1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4141   -2.3078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0097   -2.8787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8130   -3.6799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0208   -3.9102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4253   -3.3393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6331   -3.5696    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.6219   -2.5381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0781   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2535   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8189   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 15 21  4  0  0  0  0
 14 22  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  4  0  0  0  0
  8 23  4  0  0  0  0
 23 24  1  0  0  0  0
  5 24  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2925

>  <JC_XSMILES>
CSCCN1CCC2=CC=C3NC=C(C4=CC=CC(Cl)=C4)C3=C2C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1076

>  <W2 Pf proliferation inhibition EC50 uM>
0.2237

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2928
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    3.5330    0.4133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5330   -0.4117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2475   -0.8242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2475   -1.6492    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5330   -2.0617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8186   -1.6492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1041   -2.0617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8186   -0.8242    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -2.0617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -2.8867    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6764   -1.6492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3909   -2.0617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1054   -1.6492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8198   -2.0617    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.5343   -1.6492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6206   -0.8287    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.4275   -0.6572    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.8400   -1.3716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6605   -1.4579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1454   -0.7904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8099   -0.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2948    0.6307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1153    0.5444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4508   -0.2092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9659   -0.8767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2880   -1.9847    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.4595   -2.7917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2441   -3.0466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4157   -3.8536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8026   -4.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9741   -5.2126    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    9.0180   -4.1507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4049   -4.7027    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.8464   -3.3437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  2  8  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 18 26  4  0  0  0  0
 15 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 27 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2928

>  <JC_XSMILES>
CC1CN(CC(C)O1)C(=O)CCCSC2=NN=C(CC3=CC=CC=C3)N2C4=CC=C(Cl)C(Cl)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.23

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027272727

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2931
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
    1.6976   -2.7534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4120   -2.3409    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4120   -1.5159    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1265   -1.1034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1265   -0.2784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8410    0.1341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5555   -0.2784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2699    0.1341    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9844   -0.2784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9844   -1.1034    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6989    0.1341    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4133   -0.2784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4133   -1.1034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1278   -1.5159    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8815   -1.1804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4335   -1.7935    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0210   -2.5079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2760   -3.2926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7239   -3.9056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9169   -3.7341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6620   -2.9495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2140   -2.3364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1278    0.1341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8423   -0.2784    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.1278    0.9591    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8423    1.3716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8423    2.1966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1278    2.6091    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4133    2.1966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6989    2.6091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4133    1.3716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1278    3.4341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4133    3.8466    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8423    3.8466    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8423    4.6716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5567    5.0841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1278    5.0841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5555   -1.1034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8410   -1.5159    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 17 22  4  0  0  0  0
 12 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 25 31  1  0  0  0  0
 28 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 35 37  1  0  0  0  0
  7 38  4  0  0  0  0
 38 39  4  0  0  0  0
  4 39  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2931

>  <JC_XSMILES>
CCOC1=CC=C(NC(=O)NC(CC2=CNC3=CC=CC=C23)C(=O)N4CCN(C(C)C4)C(=O)NC(C)C)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2589

>  <W2 Pf proliferation inhibition EC50 uM>
0.2226

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2932
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
   -5.8804   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0554   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6429   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8179   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4054   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5804   -2.6499    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1679   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5804   -1.2210    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3429   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1129   -3.3875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -1.2680    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3086   -4.0704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0536   -4.8550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2286   -4.8550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0263   -4.0704    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8179   -3.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6429   -3.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
 13 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 23 27  4  0  0  0  0
  5 28  4  0  0  0  0
 28 29  4  0  0  0  0
  2 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2932

>  <JC_XSMILES>
CC1=CC=C(NC(=O)C2=C(N)C3=C(C4=C(CCCC4)N=C3S2)C5=CC=CS5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.442

>  <W2 Pf proliferation inhibition EC50 uM>
2.218

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024096386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2934
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  6 15  4  0  0  0  0
 10 15  4  0  0  0  0
  8 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2934

>  <JC_XSMILES>
CCN(CC)C1=NC(=NC2=CC=CC=C12)C3=CC=CN=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
5.64

>  <W2 Pf proliferation inhibition EC50 uM>
1.599

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
72.19

>  <Powder data?>
Yes

>  <IFI value>
0.007518797

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2935
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
  6 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
  3 18  4  0  0  0  0
M  CHG  1   6   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2935

>  <JC_XSMILES>
COC1=CC=[N+](OC(=O)N2CCCCC2)C(C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1875

>  <W2 Pf proliferation inhibition EC50 uM>
0.81

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
36.58

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2936
  Mrv1591402191617072D          

 21 25  0  0  0  0            999 V2000
    5.0168    0.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3340    1.1139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6826    0.6076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8705    0.7528    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387    0.1221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6190   -0.6539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4311   -0.7991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9629   -0.1684    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7875   -0.1416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0872   -1.2846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3675   -2.0605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8357   -2.6912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0235   -2.5460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7433   -1.7701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2751   -1.1393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9948   -0.3634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1827   -0.2182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0976    0.5577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4342    1.1884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2463    1.0432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5266    0.2673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  8  9  1  0  0  0  0
  1  9  1  0  0  0  0
  6 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  5 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2936

>  <JC_XSMILES>
C1CC2CC3=C(CN2C1)C4=CC=CC=C4C5=CC=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1205

>  <W2 Pf proliferation inhibition EC50 uM>
0.2211

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.035087719

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2937
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.8212    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2752   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0598   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6729   -2.0811    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5014   -2.8881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1145   -3.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8991   -3.1852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0706   -2.3782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4575   -1.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0203   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1953   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0597   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5052   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3302   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5851   -4.0207    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9177   -4.5056    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2502   -4.0207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4656   -4.2757    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2018   -3.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8693   -4.2757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6143   -5.0603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2107   -5.0603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
  7 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  6 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 23 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2937

>  <JC_XSMILES>
CCOC(=O)C1=C(CN2CCCCC2)N(N=N1)C3=NON=C3N4C=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.431

>  <W2 Pf proliferation inhibition EC50 uM>
2.21

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2941
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
  7 20  4  0  0  0  0
  5 21  4  0  0  0  0
 21 22  4  0  0  0  0
  2 22  4  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2941

>  <JC_XSMILES>
CC1=CC=C(NC2=NC(NCCO)=C3C=CC=CC3=N2)C=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1747

>  <W2 Pf proliferation inhibition EC50 uM>
0.1077

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.9

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2942
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    0.5214    4.5181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3009    4.4508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0520    3.7051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0381    5.3694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8539    5.2464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2664    4.5319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9650    3.7640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5261    3.1592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1766    3.5208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5667    4.8082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 15 29  4  0  0  0  0
 23 29  4  0  0  0  0
 10 30  1  0  0  0  0
  4 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2942

>  <JC_XSMILES>
CC1(C)C2CCC1(C)CN(CC(O)CN3C4=CC=C(Br)C=C4C5=CC(Br)=CC=C35)C2

>  <PF proliferation inhibition 3D7 EC50 uM>
2.958

>  <W2 Pf proliferation inhibition EC50 uM>
2.197

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.013888889

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2945
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    1.5395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 Sb  0  3  0  0  0  0  0  0  0  0  0  0
    2.3645   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  2  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  2 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  CHG  1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2945

>  <JC_XSMILES>
C[Sb+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1753

>  <W2 Pf proliferation inhibition EC50 uM>
0.2804

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.79

>  <Powder data?>
Yes

>  <IFI value>
0.018181818

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2947
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
  3 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
  2 22  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2947

>  <JC_XSMILES>
CC1=C(CC(=O)C2=CC=C(Cl)C=C2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.743

>  <W2 Pf proliferation inhibition EC50 uM>
1.02

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
46.6

>  <Powder data?>
Yes

>  <IFI value>
0.097560976

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2949
  Mrv1591402191617072D          

 31 36  0  0  0  0            999 V2000
   -1.4442   -2.1527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8583   -1.4392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6833   -1.4410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0974   -0.7275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6864   -0.0121    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8615   -0.0102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4474   -0.7238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6224   -0.7220    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2517   -0.0235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3956    0.7306    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6463   -0.3067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3598    0.1074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0752   -0.3035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7888    0.1106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5041   -0.3004    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5060   -1.1254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7924   -1.5394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0770   -1.1285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3635   -1.5426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6481   -1.1317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1360   -1.3884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3892   -2.1735    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3653   -2.3676    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6517   -2.7817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0807   -2.7785    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4997   -0.9923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7862   -1.4064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0708   -0.9955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0690   -0.1705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7825    0.2436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4979   -0.1673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 11 20  1  0  0  0  0
 20 21  1  0  0  0  0
  8 21  1  0  0  0  0
 21 22  2  0  0  0  0
 19 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 19 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 12 31  1  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2949

>  <JC_XSMILES>
CC1=CC=CC=C1N2C(=O)C3C4C5=CC=CC=C5C(C3C2=O)(C(O)=O)C6=CC=CC=C46

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.187

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2950
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7550   -0.0769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3070   -0.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8945   -1.4045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0875   -1.2330    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
  3 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 22 23  2  0  0  0  0
 13 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  3  0  0  0  0
 19 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 27 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2950

>  <JC_XSMILES>
COC1=CC=C2C=CC=CC2=C1C3CC(=O)N4CN(CSC4=C3C#N)CC5=CC=CO5

>  <PF proliferation inhibition 3D7 EC50 uM>
3.32

>  <W2 Pf proliferation inhibition EC50 uM>
2.181

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2951
  Mrv1591402191617072D          

 31 33  0  0  1  0            999 V2000
    2.0367    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -3.8062    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.3387   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.0215    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.2991   -2.7666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1276   -1.9596    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6860   -3.3186    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8576   -4.1256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2445   -4.6776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6486   -4.4736    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3130   -5.2273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7980   -5.8947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4624   -6.6484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9473   -7.3158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7678   -7.2296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6118   -8.0695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7913   -8.1557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3064   -7.4883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6419   -6.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9004   -6.3730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5271   -5.9176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  1  0  0  0  0
 14 13  1  0  0  0  0
 14 10  1  0  0  0  0
 14 15  1  1  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 12 20  1  1  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 23 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2951

>  <JC_XSMILES>
CCCN1CCC(CC1)N2C[C@H](C[C@H]2C(=O)NCC)NCCC3=C(C)CCCC3(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
2.342

>  <W2 Pf proliferation inhibition EC50 uM>
0.765

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
35.1

>  <Powder data?>
Yes

>  <IFI value>
0.03

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2957
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    1.4455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
 12 17  4  0  0  0  0
 10 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2957

>  <JC_XSMILES>
CC1=CC=CC=C1CN2C(=NC3=CC=CC=C23)N4CCC(CC4)C(=O)NCC5=CC=CC=N5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.937

>  <W2 Pf proliferation inhibition EC50 uM>
2.155

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2960
  Mrv1591402191617072D          

 18 21  0  0  0  0            999 V2000
    2.7622   -2.2184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3023   -2.8421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1124   -2.6861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3825   -1.9066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8424   -1.2829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0323   -1.4389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1124   -0.5034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9226   -0.3475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4627   -0.9711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2728   -0.8152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8129   -1.4389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6230   -1.2829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1631   -1.9066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8931   -2.6861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0829   -2.8421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5428   -2.2184    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.7327   -2.3743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1926   -1.7507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  4  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  1  6  4  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  4 18  4  0  0  0  0
  9 18  4  0  0  0  0
M  CHG  1  16   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2960

>  <JC_XSMILES>
C1=CC=C2C(=C1)C=CC3=CC4=CC=CC=[N+]4C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
1.377

>  <W2 Pf proliferation inhibition EC50 uM>
0.795

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
36.95

>  <Powder data?>
Yes

>  <IFI value>
0.090909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2961
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    5.2520   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    1.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145   -1.0164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  8 18  1  0  0  0  0
  3 18  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2961

>  <JC_XSMILES>
COC1=CC(=O)C2=C(C=CC3=CC(O)=CC=C23)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.767

>  <W2 Pf proliferation inhibition EC50 uM>
0.2151

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.070175439

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2962
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5429    2.0445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2775    2.1307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6131    1.3770    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  2  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2962

>  <JC_XSMILES>
CN1C(=O)C2=C(CCS2)N=C1SCC(=O)NC3=CC=CC(F)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.38

>  <W2 Pf proliferation inhibition EC50 uM>
2.151

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2963
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -4.2962    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7087    1.4455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9962   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  3  0  0  0  0
  6 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  3  0  0  0  0
 21 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  4  0  0  0  0
 24 32  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  32
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2963

>  <JC_XSMILES>
CCOC1=CC(=CC=C1OCC2=CC=CC=C2C#N)\C=C(/C#N)C3=NC4=CC=CC=C4N3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.117

>  <W2 Pf proliferation inhibition EC50 uM>
0.2143

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2964
  Mrv1591402191617072D          

 38 43  0  0  0  0            999 V2000
   -4.6599   -2.7293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8349   -2.7292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4223   -3.4437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5973   -3.4437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0453   -4.0567    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2916   -3.7211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3779   -2.9006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7648   -2.3486    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9364   -1.5416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1294   -1.3700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7434   -1.7132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1080   -0.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4949   -0.1826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1182    0.3695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0572   -0.7956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0470    0.4305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1849   -2.7292    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5974   -2.0147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4224   -2.0148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.1336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.9586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1374   -5.3710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8519   -4.9585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8518   -4.1335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -3.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -2.8960    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -2.4835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5662   -2.8960    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -1.6585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -1.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5873   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -0.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 33 34  1  0  0  0  0
 32 33  1  0  0  0  0
 31 36  1  0  0  0  0
 29 37  1  0  0  0  0
 35 36  1  0  0  0  0
 33 38  1  0  0  0  0
 35 37  1  0  0  0  0
 34 35  1  0  0  0  0
 29 38  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2964

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C45CC6CC(CC(C6)C4)C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.788

>  <W2 Pf proliferation inhibition EC50 uM>
0.2141

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.020408163

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2965
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
   -2.6462    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
  2 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2965

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)C2=NC3=CC=CC=C3N2)C4=CC=CC=C4OC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.577

>  <W2 Pf proliferation inhibition EC50 uM>
2.14

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.06741573

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2966
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4723   -0.9645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.1367   -1.7182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3162   -1.6320    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2966

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC=C4OCOC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2493

>  <W2 Pf proliferation inhibition EC50 uM>
0.214

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2967
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  9 19  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
  2 20  4  0  0  0  0
  7 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2967

>  <JC_XSMILES>
BrC1=CC=C2N=C(C=C(C(=O)NC3=CC=CN=C3)C2=C1)C4=CC=CN=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.138

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-297
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.8138    3.1553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5588    2.3707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481    2.1991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042    1.5317    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757    2.3387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902    2.7512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902    3.5762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757    3.9887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612    3.5762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612    2.7512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  3 11  1  0  0  0  0
  6 11  4  0  0  0  0
  4 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
M  CHG  1  24   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-297

>  <JC_XSMILES>
CC[N+]1=C(SC2=CC=CC=C12)\C=C(C)\C=C3/SC4=CC=CC=C4N3CCO

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.641

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2970
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  3  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  1 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 10 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2970

>  <JC_XSMILES>
C(C#CC1=CC=CC=C1)N(CC2=CC=CC=N2)CC3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.557

>  <W2 Pf proliferation inhibition EC50 uM>
0.3

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>14.1

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2971
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    5.6424   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.5396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.9979    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1806    3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.5306    3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -0.1006    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -0.5422    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507   -1.9399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957   -2.7246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7478   -3.3376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6112   -2.8961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1633   -2.2830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083   -1.4984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604   -0.8853    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 14 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
 33 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2971

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2=NC3=C(C=NN3C(=C2)C(F)(F)F)C(=O)NC4=CC(C)=CC=C4O

>  <PF proliferation inhibition 3D7 EC50 uM>
3.35

>  <W2 Pf proliferation inhibition EC50 uM>
2.127

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034482759

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2972
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
  8 20  4  0  0  0  0
 20 21  4  0  0  0  0
  5 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2972

>  <JC_XSMILES>
ClCCSC1=CC=C(SC2=CC=C(SCCCl)C=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.125

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015151515

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2973
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539    0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039    0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  5  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
  4 13  4  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2973

>  <JC_XSMILES>
OC1=CC2=C(C=C1Cl)C(=CC(=O)O2)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.125

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.036036036

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2977
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 10 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
  8 24  4  0  0  0  0
  6 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2977

>  <JC_XSMILES>
FC1=CC=CC(NC2=NC(NCC3CCCO3)=C4C=CC=CC4=N2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.142

>  <W2 Pf proliferation inhibition EC50 uM>
0.2034

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.58

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2981
  Mrv1591402191617072D          

 36 40  0  0  1  0            999 V2000
    5.1122    0.4087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5435    1.0063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7416    0.8126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5084    0.0212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0771   -0.5764    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7036   -0.2891    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1319    0.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3358    0.2314    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.2249   -0.5861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8774   -1.0909    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7665   -1.9085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6408   -0.7783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2933   -1.2831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7517    0.0393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0992    0.5441    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2101    1.3616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4410    1.8693    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4962    2.6891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1168    1.6175    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.8021    1.8141    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0353    2.6055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4666    3.2031    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8373    2.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0704    3.5906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8724    3.7843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4411    3.1867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2430    3.3804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4762    4.1718    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8118    2.7828    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5786    1.9914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7767    1.7977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7670    0.8290    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.0046    0.5371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7942    1.5537    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.0307    1.5426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3721    2.2626    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  4  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  0  0  0  0
  8  9  1  6  0  0  0
 10  9  1  0  0  0  0
 10 11  1  1  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
 15 14  1  0  0  0  0
  8 15  1  0  0  0  0
 15 16  1  6  0  0  0
 17 16  1  0  0  0  0
 17 18  1  1  0  0  0
 19 18  1  1  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 23 21  1  4  0  0  0
 23 24  2  0  0  0  0
 25 24  1  4  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
  2 31  1  0  0  0  0
 32 19  1  0  0  0  0
 32  8  1  0  0  0  0
 32 33  1  1  0  0  0
 32 34  1  0  0  0  0
 34 17  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 34 36  1  1  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2981

>  <JC_XSMILES>
CC1=CC(=O)OC[C@]23C[C@H](O)C(C)=C[C@H]2O[C@@H]4C[C@@H](OC(=O)C=CC=CC(=O)OCC1)[C@@]3(C)[C@]45CO5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.002435

>  <W2 Pf proliferation inhibition EC50 uM>
0.001772

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.0837

>  <Powder data?>
No

>  <IFI value>
0.226415094

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2982
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 19 25  4  0  0  0  0
 15 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 13 28  4  0  0  0  0
 28 29  4  0  0  0  0
  9 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2982

>  <JC_XSMILES>
CCN1CCN(CC1)C2=CC(C)=C3C=C(NC(=O)C4=CN=CC(Br)=C4)C=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2652

>  <W2 Pf proliferation inhibition EC50 uM>
0.411

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.43

>  <Powder data?>
Yes

>  <IFI value>
0.033333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2985
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
  5 17  4  0  0  0  0
 17 18  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2985

>  <JC_XSMILES>
CCCCC1=C(C)N=C2C(OC)=CC=CC2=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.689

>  <W2 Pf proliferation inhibition EC50 uM>
2.114

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2986
  Mrv1591402191617072D          

 16 16  0  0  0  0            999 V2000
   -1.4289    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020    4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2986

>  <JC_XSMILES>
CC(C)(C)NC(=S)NC1=CC=CC(Cl)=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>7.24

>  <W2 Pf proliferation inhibition EC50 uM>
2.113

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2988
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743    0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 19 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2988

>  <JC_XSMILES>
CC(C)(C)C1=CC=C(C=C1)C(=O)NCCCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1765

>  <W2 Pf proliferation inhibition EC50 uM>
0.2304

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.93

>  <Powder data?>
No

>  <IFI value>
0.031914894

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2990
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
 19 28  4  0  0  0  0
 17 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 15 31  4  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  2  0  0  0  0
 11 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 35 40  4  0  0  0  0
 40 41  4  0  0  0  0
  9 41  4  0  0  0  0
M  CHG  2  32   1  33  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2990

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=CC(C(=O)NC3=CC(OC4=CC=C(NC(C)=O)C=C4)=CC(=C3)[N+]([O-])=O)=C5C=CC=CC5=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.106

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034090909

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2991
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
   -1.9317   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1067   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5433   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  4  0  0  0  0
  8 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2991

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=NN3C(O)=C4CCCCC4=NC3=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.603

>  <W2 Pf proliferation inhibition EC50 uM>
2.103

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2992
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 13 23  4  0  0  0  0
 17 23  4  0  0  0  0
 15 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
  9 30  4  0  0  0  0
 30 31  4  0  0  0  0
  6 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2992

>  <JC_XSMILES>
CCOC(=O)C1=CC=C(NC(=O)C2=CC(=NC3=CC=C(C)C=C23)C4=CC=CC=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.1

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034883721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2993
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309    1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 12 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
 10 30  1  0  0  0  0
 30 31  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2993

>  <JC_XSMILES>
COC1=CC=CC=C1NC2=CC(=NS(=O)(=O)C3=CC=C(F)C=C3)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.375

>  <W2 Pf proliferation inhibition EC50 uM>
0.431

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.55

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2998
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 19 25  1  0  0  0  0
 11 26  4  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2998

>  <JC_XSMILES>
COC1=CC=C2N=C(C)C=C(NC3=CC=C(C=C3)N4CCN(C)CC4)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0832

>  <W2 Pf proliferation inhibition EC50 uM>
0.1529

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.33

>  <Powder data?>
Yes

>  <IFI value>
0.055944056

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-300
  Mrv1591402191617072D          

 28 29  0  0  0  0            999 V2000
    0.7145   -7.0125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
  6 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-300

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(=CC=C1SCC(=O)NCC=C)C(=O)NC2=CC=C(Cl)C=C2F

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.169

>  <W2 Pf proliferation inhibition EC50 uM>
>1.634

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3000
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  2  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 31 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  2  0  0  0  0
M  CHG  2  34   1  35  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3000

>  <JC_XSMILES>
CCC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N(C)C(=O)\C=C\C4=CC=C(C=C4)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2665

>  <W2 Pf proliferation inhibition EC50 uM>
0.1739

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.35

>  <Powder data?>
No

>  <IFI value>
0.009259259

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3002
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -1.4211   -0.1494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -0.4849    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396    1.8646    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4875    2.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3194    2.3061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8715    2.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6165    3.7038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1904    3.8754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7425    3.2623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5494    3.4338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8465   -1.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1015   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5494   -2.6088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8044   -3.3934    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7425   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4875   -1.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  4  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
  5 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 14 24  1  0  0  0  0
  3 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3002

>  <JC_XSMILES>
CSC1=NC(=NC2=CC=CC=C2C)C3(CCC(CC3)C(C)(C)C)N1C4=CC=C(O)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2428

>  <W2 Pf proliferation inhibition EC50 uM>
0.208

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3003
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6816   -0.4647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4700   -0.2216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7714    0.5464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3589    1.2609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5431    1.3838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0617    0.8227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  2  0  0  0  0
  2  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
  7 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
  6 23  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3003

>  <JC_XSMILES>
CN(C(C)=O)C1=C(N2CCCCCC2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0358

>  <W2 Pf proliferation inhibition EC50 uM>
0.0386

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.857

>  <Powder data?>
Yes

>  <IFI value>
0.224719101

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3005
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
  2 12  4  0  0  0  0
 12 13  1  0  0  0  0
  7 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   3
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3005

>  <JC_XSMILES>
CC1=NC2=C(C)C(=NN2C(O)=C1C)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.021

>  <W2 Pf proliferation inhibition EC50 uM>
2.077

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015384615

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3007
  Mrv1591402191617072D          

 76 83  0  0  1  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.0993   -9.7567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5690  -10.6752    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  6  0  0  0
  4  3  1  6  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  1  0  0  0
 12 13  1  0  0  0  0
 14 13  1  0  0  0  0
 14 15  1  1  0  0  0
 16 15  1  6  0  0  0
 16 17  1  0  0  0  0
 18 17  1  0  0  0  0
 18 19  1  1  0  0  0
 20 18  1  0  0  0  0
 20 21  1  1  0  0  0
 20 22  1  0  0  0  0
 22 23  1  1  0  0  0
 22 24  1  0  0  0  0
 16 24  1  0  0  0  0
 25 14  1  0  0  0  0
 25 26  1  1  0  0  0
 25 27  1  0  0  0  0
 27 28  1  6  0  0  0
 27 29  1  0  0  0  0
 12 29  1  0  0  0  0
 10 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
  8 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 35 37  4  0  0  0  0
  6 37  4  0  0  0  0
 37 38  1  0  0  0  0
 38 39  2  0  0  0  0
 40 38  1  0  0  0  0
  4 40  1  0  0  0  0
 40 41  1  1  0  0  0
 42 41  1  1  0  0  0
 42 43  1  0  0  0  0
 44 43  1  0  0  0  0
 44 45  1  1  0  0  0
 46 45  1  1  0  0  0
 46 47  1  0  0  0  0
 48 47  1  0  0  0  0
 48 49  1  1  0  0  0
 50 49  1  1  0  0  0
 50 51  1  0  0  0  0
 52 51  1  0  0  0  0
 52 53  1  1  0  0  0
 52 54  1  6  0  0  0
 55 52  1  0  0  0  0
 55 56  1  1  0  0  0
 55 57  1  0  0  0  0
 57 58  1  6  0  0  0
 57 59  1  0  0  0  0
 50 59  1  0  0  0  0
 60 48  1  0  0  0  0
 60 61  1  6  0  0  0
 60 62  1  0  0  0  0
 62 63  1  1  0  0  0
 62 64  1  0  0  0  0
 46 64  1  0  0  0  0
 65 44  1  0  0  0  0
 65 66  1  6  0  0  0
 65 67  1  0  0  0  0
 67 68  1  6  0  0  0
 67 69  1  0  0  0  0
 42 69  1  0  0  0  0
  3 70  1  0  0  0  0
 70 71  2  0  0  0  0
 72 70  1  0  0  0  0
 72 73  1  6  0  0  0
 72 74  1  0  0  0  0
 74 75  1  0  0  0  0
 74 76  1  1  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3007

>  <JC_XSMILES>
CO[C@@H]([C@@H]1CC2=CC3=CC(O[C@H]4C[C@@H](O[C@@H]5C[C@@H](O)[C@@H](O)[C@@H](C)O5)[C@@H](O)[C@H](C)O4)=C(C)C(O)=C3C(O)=C2C(=O)[C@H]1O[C@H]6C[C@@H](O[C@H]7C[C@@H](O[C@H]8C[C@](C)(O)[C@@H](O)[C@H](C)O8)[C@H](O)[C@@H](C)O7)[C@H](O)[C@H](C)O6)C(=O)[C@@H](O)[C@@H](C)O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.497

>  <W2 Pf proliferation inhibition EC50 uM>
0.2076

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.09375

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3011
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 14 21  4  0  0  0  0
 21 22  1  0  0  0  0
 10 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 29 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  2  0  0  0  0
 24 35  4  0  0  0  0
  8 35  4  0  0  0  0
  6 36  4  0  0  0  0
 36 37  4  0  0  0  0
  3 37  4  0  0  0  0
M  CHG  2  32   1  33  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3011

>  <JC_XSMILES>
COC1=CC=C(NC2=NC(NN=CC3=CC(Br)=C(O)C=C3O)=NC(NC4=CC=C(C=C4)[N+]([O-])=O)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.075

>  <W2 Pf proliferation inhibition EC50 uM>
0.1979

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.58

>  <Powder data?>
No

>  <IFI value>
0.139534884

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3012
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 14 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 12 28  4  0  0  0  0
 28 29  4  0  0  0  0
  8 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3012

>  <JC_XSMILES>
CN1CCN(CC1)C2=CC(C)=C3C=C(NC(=O)NC4=CC=CC=C4Cl)C=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
3.098

>  <W2 Pf proliferation inhibition EC50 uM>
2.06

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3015
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -4.6480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -6.0770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3015

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)S(=O)(=O)C3=CC(Cl)=CC=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.398

>  <W2 Pf proliferation inhibition EC50 uM>
0.2508

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>12.19

>  <Powder data?>
No

>  <IFI value>
0.074074074

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3016
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -5.5337   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 17 25  4  0  0  0  0
  5 26  4  0  0  0  0
 26 27  4  0  0  0  0
  2 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3016

>  <JC_XSMILES>
CC1=CC=C(OCC(=O)NC2=CC=CC(=C2)C3=NC4=NC=CC=C4O3)C=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.898

>  <W2 Pf proliferation inhibition EC50 uM>
2.054

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3018
  Mrv1591402191617072D          

 18 18  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
M  CHG  2  16   1  17  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3018

>  <JC_XSMILES>
CC(=O)NC(CO)C(O)C1=CC=C(C=C1)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.72

>  <W2 Pf proliferation inhibition EC50 uM>
2.051

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-302
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
  5 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 36 37  4  0  0  0  0
  3 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-302

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=C(F)C=C2)C(=O)NC3=CC=C(Br)C=C3)=C4N=CC=CC4=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.927

>  <W2 Pf proliferation inhibition EC50 uM>
0.691

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.24

>  <Powder data?>
No

>  <IFI value>
0.037735849

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3020
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 10 16  4  0  0  0  0
  5 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
  4 25  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3020

>  <JC_XSMILES>
CN(C)C1=C(N(C(C)=O)C2=CC=CC(Cl)=C2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02727

>  <W2 Pf proliferation inhibition EC50 uM>
0.0649

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.18

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3021
  Mrv1591402191617072D          

 26 30  0  0  1  0            999 V2000
    4.3925   -1.8238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9076   -1.1564    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0871   -1.2426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7516   -1.9963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9311   -2.0825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4462   -1.4151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7817   -0.6614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6022   -0.5752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2968    0.0060    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.4718    0.0060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2169    0.7907    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4506    1.2756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1956    2.0602    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6294    2.0602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1143    2.7276    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8843    1.2756    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1392    2.0602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9642    2.0602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2192    1.2756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5517    0.7907    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6806    2.7276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5010    2.6414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9860    3.3088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6504    4.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8299    4.1487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3450    3.4813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  9  7  1  6  0  0  0
  9 10  1  0  0  0  0
 11 10  1  1  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 16 14  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
  9 20  1  0  0  0  0
 16 20  1  1  0  0  0
 13 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3021

>  <JC_XSMILES>
CSC1=CC=CC(=C1)[C@@H]2C[C@H]3CN(C(=O)[C@]34CCCN24)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.208

>  <W2 Pf proliferation inhibition EC50 uM>
0.48

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.54

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3028
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 21 31  4  0  0  0  0
 25 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3028

>  <JC_XSMILES>
CCCCCCC1=CC=C(C=C1)C(=O)N(C)CCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.67

>  <W2 Pf proliferation inhibition EC50 uM>
0.2192

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.82

>  <Powder data?>
No

>  <IFI value>
0.042105263

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3029
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.5363   -4.3437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7913   -3.5590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5983   -3.3875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5983   -0.4834    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1503    0.1297    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7634   -0.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5372    0.6817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7023    0.7428    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
  8 11  2  0  0  0  0
  6 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  4 22  4  0  0  0  0
 12 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3029

>  <JC_XSMILES>
CCCN1N=C(NS(C)(=O)=O)C2=CC3=CC=CC(C)=C3N=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.1

>  <W2 Pf proliferation inhibition EC50 uM>
2.025

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-303
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  4  0  0  0  0
  7 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
  5 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-303

>  <JC_XSMILES>
CC1=CC=C2N=C(NC3=NC(O)=C4C=CC=CC4=N3)N=C(C)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.575

>  <W2 Pf proliferation inhibition EC50 uM>
>1.622

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3030
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3848   -1.0942    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8545   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0793   -2.2949    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.6298   -1.7306    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.1367   -2.7880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4189   -3.5632    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.3614   -3.0702    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.9119   -2.5058    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
  6 13  4  0  0  0  0
 13 14  4  0  0  0  0
  3 14  4  0  0  0  0
 10 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3030

>  <JC_XSMILES>
COC1=CC=C2C(=O)CC(O)(OC2=C1)C(F)(F)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.442

>  <W2 Pf proliferation inhibition EC50 uM>
1.005

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
49.7

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3032
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    5.0030   -5.6570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4509   -5.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6439   -5.2155    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3890   -6.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5820   -6.1716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919   -4.6024    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.7050   -4.0503    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4788   -5.1544    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7302    1.0972    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.2483    1.7326    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0947    0.1187    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 20 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 17 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3032

>  <JC_XSMILES>
CCN(CC)S(=O)(=O)C1=CC=C(C=C1)C(=O)C2=C(C)C(C(=O)C(F)(F)F)=C3C=CC=CN23

>  <PF proliferation inhibition 3D7 EC50 uM>
3.148

>  <W2 Pf proliferation inhibition EC50 uM>
2.02

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3034
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 13 26  4  0  0  0  0
 17 26  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3034

>  <JC_XSMILES>
COC1=CC(NCCCC(C)NC2=CC=NC3=CC4=CC=CC=C4C=C23)=C5N=CC=CC5=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0835

>  <W2 Pf proliferation inhibition EC50 uM>
0.0499

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.472

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3037
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5819    0.9475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3889    1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8014    0.4046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2494   -0.2085    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3686   -2.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1532   -1.8249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1532   -0.9999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3686   -0.7450    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 14 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 12 25  4  0  0  0  0
 25 26  4  0  0  0  0
 10 26  4  0  0  0  0
  2 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 27 31  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  26
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3037

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)C2=NC3=CC(NC(=O)C4=CC=CS4)=CC=C3N2)C5=CC=CS5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.546

>  <W2 Pf proliferation inhibition EC50 uM>
2.008

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-304
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    7.7525   -1.2991    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7054   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4505   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6255   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3706   -3.0215    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    2.4134    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    4.8884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -2.1241    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  3  7  4  0  0  0  0
  2  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  8 24  1  0  0  0  0
 24 25  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-304

>  <JC_XSMILES>
O=C(C1=CC=CS1)\C(=C\NC2CCN(CC2)CC3=CC=CC=C3)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2203

>  <W2 Pf proliferation inhibition EC50 uM>
1.622

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.025

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3040
  Mrv1591402191617072D          

 24 28  0  0  0  0            999 V2000
    3.6633   -1.1567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0645    1.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6165    2.0803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4235    1.9087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0909    2.3937    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7583    1.9087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5034    1.1241    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6784    1.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 12  4  0  0  0  0
 12 13  4  0  0  0  0
  5 13  4  0  0  0  0
  3 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  2 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3040

>  <JC_XSMILES>
O=C1N(CC2=CC=C3OCOC3=C2)C=NC4=C1NC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.030769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3042
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -1.2563    3.3196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5889    3.8045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5889    4.6295    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    4.8844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6807    4.2170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    3.5496    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5057    4.2170    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.9182    4.9315    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.9182    3.5025    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 13 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 12 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
  5 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  2  0  0  0  0
M  CHG  2  30   1  31  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3042

>  <JC_XSMILES>
CC1=NC=C(N1CCOC(=O)C2=C(NC(=O)C3=CC=CC=C3)SC4=C2CCCC4)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.604

>  <W2 Pf proliferation inhibition EC50 uM>
1.999

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015037594

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3044
  Mrv1591402191617072D          

 25 29  0  0  0  0            999 V2000
   -1.9851   -7.0904    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5002   -6.4229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8328   -6.9078    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1677   -5.9380    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0154   -5.7555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3509   -5.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8661   -4.3343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0456   -4.4205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2900   -5.1742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1949   -5.8417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4393   -3.7531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1843   -2.9685    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -2.4835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5192   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2643   -3.7530    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -1.6585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -1.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5873   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -0.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
 19 20  1  0  0  0  0
 18 23  1  0  0  0  0
 16 24  1  0  0  0  0
 22 23  1  0  0  0  0
 20 25  1  0  0  0  0
 22 24  1  0  0  0  0
 21 22  1  0  0  0  0
 16 25  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3044

>  <JC_XSMILES>
FC(F)(F)C1=CC=C(C=C1)C2=NC(=CS2)C34CC5CC(CC(C5)C3)C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.568

>  <W2 Pf proliferation inhibition EC50 uM>
0.1998

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.042553191

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3045
  Mrv1591402191617072D          

 31 32  0  0  0  0            999 V2000
    3.3810   -5.8757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9211   -5.2520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7313   -5.4079    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8114   -6.3434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2713   -4.7843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0815   -4.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6216   -4.3166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4317   -4.4725    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9718   -3.8488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7017   -3.0693    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.7819   -4.0048    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0520   -4.7843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5119   -5.4079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7819   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.5921   -6.3434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2418   -6.8111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3220   -3.3811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1321   -3.5370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6722   -2.9134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4824   -3.0693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0225   -2.4457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8326   -2.6016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3727   -1.9779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1026   -3.3811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5625   -4.0048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8326   -4.7843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7524   -3.8488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2123   -4.4725    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4022   -4.3166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8621   -4.9402    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 12 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 21 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 19 30  4  0  0  0  0
 30 31  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  29
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3045

>  <JC_XSMILES>
CCN(CC)CCCNC(=S)N(CCN(C)C)CC1=CC2=CC(C)=CC(C)=C2NC1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.421

>  <W2 Pf proliferation inhibition EC50 uM>
1.995

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.033898305

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3046
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.5935    0.1228    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.3080    0.5353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3080    1.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0224    1.7728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7369    1.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4514    1.7728    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.1659    1.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8803    1.7728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8803    2.5978    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5948    1.3603    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3093    1.7728    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0237    1.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7774    1.6958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9489    2.5028    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3294    1.0827    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9169    0.3683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1719   -0.4164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6199   -1.0295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8129   -0.8579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5579   -0.0733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1100    0.5398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7369    0.5353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0224    0.1228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 11 10  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  1  0  0  0  0
 16 21  4  0  0  0  0
  5 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3046

>  <JC_XSMILES>
ClC1=CC=C(SCC(=O)NN=C2C(=O)NC3=CC=CC=C23)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>1.992

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3048
  Mrv1591402191617072D          

 27 30  0  0  1  0            999 V2000
    1.5251   -1.8166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -1.8166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -0.5791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    0.6584    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.2396    1.0709    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2396    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    2.3084    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.0915    1.7584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0915    1.2084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    0.6584    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.8959    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.3830    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    0.6584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.8959    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  1  0  0  0
  8  7  1  1  0  0  0
  8  9  1  0  0  0  0
 10  9  1  1  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 13 14  1  0  0  0  0
 15 14  1  0  0  0  0
 10 15  1  0  0  0  0
 15 16  1  1  0  0  0
 16 17  2  0  0  0  0
  7 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3048

>  <JC_XSMILES>
CC(C)C(=O)O[C@H]([C@H]1C[C@@H]2CCN1C[C@@H]2C=C)C3=CC=NC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.318

>  <W2 Pf proliferation inhibition EC50 uM>
0.1992

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.016666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3051
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.5356    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    3.1152    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.8777    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.2902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    2.2902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    2.2902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.0527    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.0527    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.1848    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8476   -0.6697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926   -1.4544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676   -1.4544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -0.6697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 14 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 12 24  4  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 25 29  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  24
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3051

>  <JC_XSMILES>
CC1=CC=C(C=C1)C(=O)NNC2=NC(NC3=CC=CC=C3)=NC(=N2)N4CCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.987

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.00729927

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3052
  Mrv1591402191617072D          

 29 30  0  0  0  0            999 V2000
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -4.8395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -3.4105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 14 22  4  0  0  0  0
 10 22  4  0  0  0  0
 22 23  2  0  0  0  0
 12 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3052

>  <JC_XSMILES>
CCC(COC)NC(=O)C1=CN(C=C(C(=O)NC(C)(C)C)C1=O)C2CCCCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
2.903

>  <W2 Pf proliferation inhibition EC50 uM>
1.985

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.017094017

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3054
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -8.2500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.7487   -7.4250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.3987   -7.4250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0888   -4.1295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8958   -3.9580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3083   -4.6725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7563   -5.2856    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  3  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 22 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3054

>  <JC_XSMILES>
CCOC(=O)CCCSC1=NC(=CC(=C1C#N)C(F)(F)F)C2=CC=CS2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.352

>  <W2 Pf proliferation inhibition EC50 uM>
0.1983

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.072727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3057
  Mrv1591402191617072D          

 36 41  0  0  0  0            999 V2000
    6.3269    3.0739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5474    2.8036    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3918    1.9934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0157    1.4535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8601    0.6434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0807    0.3730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4568    0.9128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6124    1.7230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6774    0.6425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0005    1.1142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3427    0.6162    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6131   -0.1633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9554   -0.6613    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2785   -0.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4750   -0.3770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0890    0.2251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1505    1.0146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9539    1.2020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5179    0.5999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8924    0.0377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4564    0.6398    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1318   -0.7518    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9353   -0.9392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1747   -1.7287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9781   -1.9161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5421   -1.3140    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3027   -0.5245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4993   -0.3371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3456   -1.5014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9096   -0.8993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7130   -1.0867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2770   -0.4846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0376    0.3049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2342    0.4923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6701   -0.1098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4379   -0.1470    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
 14 19  4  0  0  0  0
 16 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 12 36  4  0  0  0  0
  9 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3057

>  <JC_XSMILES>
COC1=CC=CC(=C1)C2=CN3C(SC4=CC(=CC=C34)C(=O)NC5CCN(CC5)CC6=CC=CC=C6)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.513

>  <W2 Pf proliferation inhibition EC50 uM>
1.976

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.105263158

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3058
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    8.5688    3.8245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5945    2.9999    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.3215    2.6099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8933    2.5653    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.4587    3.2665    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3279    1.8640    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1920    2.1307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2178    1.3061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5166    0.8714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7896    1.2614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7638    2.0860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4650    2.5206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0883    0.8268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1141    0.0022    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3613    1.2168    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6601    0.7822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8963    1.0941    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3637    0.4640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7983   -0.2372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5995   -0.0406    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4083   -0.9642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5837   -0.9900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1491   -0.2887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3245   -0.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1101    0.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2799    1.1137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1045    1.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391    0.4383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 18 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3058

>  <JC_XSMILES>
CN(C)S(=O)(=O)C1=CC=C(C=C1)C(=O)NC2=NC3=C(S2)C=CC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.47

>  <W2 Pf proliferation inhibition EC50 uM>
1.971

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3060
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3060

>  <JC_XSMILES>
CCCC1=CC=C(C=C1)C(=O)NC(=O)C2=CC=CC=C2O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1928

>  <W2 Pf proliferation inhibition EC50 uM>
0.325

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.49

>  <Powder data?>
Yes

>  <IFI value>
0.061068702

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3063
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    2.9945    1.5193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2355    1.1959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5760    1.6916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1360    0.3770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3323    0.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8821    0.8817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8367   -0.4691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2754    0.0013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4719   -0.3483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5428   -1.1702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1336   -1.6426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8809   -1.2930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4443   -1.8956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2633   -1.9951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9546   -1.5449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6141   -2.0406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731   -1.7173    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1948   -0.7557    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8715    0.0034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4742    0.5668    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0453   -2.6177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2352   -2.4613    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2900   -1.5198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6396   -0.7726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0373   -1.8694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7137   -1.3971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4609   -1.7467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1373   -1.2744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8846   -1.6240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0665   -0.4524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9404   -2.2671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4128   -2.9435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
  4 19  1  0  0  0  0
 19 20  2  0  0  0  0
 13 21  4  0  0  0  0
 21 22  4  0  0  0  0
 11 22  4  0  0  0  0
 10 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 23 31  1  0  0  0  0
 31 32  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  22
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3063

>  <JC_XSMILES>
CC(C)C1N(C)C2=CC=C(C3=C2C(CC(CO)NC1=O)=CN3)C(C)(CCC=C(C)C)C=C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.552

>  <W2 Pf proliferation inhibition EC50 uM>
0.1967

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.113207547

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3064
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  8  7  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
  7 22  4  0  0  0  0
  3 22  4  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3064

>  <JC_XSMILES>
COC1=CC=CC(C=NNC(=O)CSC2=CC=CC=C2C)=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
7.94

>  <W2 Pf proliferation inhibition EC50 uM>
1.964

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3066
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -6.0770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -4.6480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 18 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3066

>  <JC_XSMILES>
COC1=CC=C(C=C1)S(=O)(=O)N(C)CCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1154

>  <W2 Pf proliferation inhibition EC50 uM>
0.1968

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.06

>  <Powder data?>
No

>  <IFI value>
0.101851852

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3068
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -4.6480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -6.0770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.0125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  2  0  0  0  0
M  CHG  2  27   1  28  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3068

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)S(=O)(=O)C3=CC=C(C=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2395

>  <W2 Pf proliferation inhibition EC50 uM>
0.2172

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.12

>  <Powder data?>
No

>  <IFI value>
0.055045872

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3075
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4257   -5.3493    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7679   -2.3346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5884   -2.2483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0733   -2.9158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7378   -3.6695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2227   -4.3369    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0432   -4.2507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5281   -4.9181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1925   -5.6718    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6775   -6.3392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3721   -5.7580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8871   -5.0906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 21 27  1  0  0  0  0
  9 28  4  0  0  0  0
 28 29  4  0  0  0  0
  6 29  4  0  0  0  0
 28 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3075

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N(CCC(=O)NC2=CC=CC=C2N3CCN(C)CC3)C(=C1)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.794

>  <W2 Pf proliferation inhibition EC50 uM>
0.336

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.28

>  <Powder data?>
Yes

>  <IFI value>
0.029411765

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3076
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
 15 20  4  0  0  0  0
  6 21  4  0  0  0  0
  2 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3076

>  <JC_XSMILES>
CC1=CC=CC(NC(=O)C2=CC(Cl)=NC3=CC=CC=C23)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
3.67

>  <W2 Pf proliferation inhibition EC50 uM>
1.936

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.020833333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3077
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -5.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -5.4349    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  2  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3077

>  <JC_XSMILES>
O=C(CC1=CC=CS1)N2CCN(CC2)C3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
3.95

>  <W2 Pf proliferation inhibition EC50 uM>
1.932

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3082
  Mrv1591402191617072D          

 24 28  0  0  0  0            999 V2000
   -1.4856   -2.8806    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -3.4326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -4.2576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -4.6701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -4.2576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -3.4326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -3.0201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6417   -2.2131    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  4  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  1  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1   1
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  24
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3082

>  <JC_XSMILES>
N1C2=CC=CC=C2N=C1C3=CC=CC(=N3)C4=NC5=CC=CC=C5N4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.686

>  <W2 Pf proliferation inhibition EC50 uM>
0.916

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
47.54

>  <Powder data?>
Yes

>  <IFI value>
0.029850746

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3083
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3083

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C(C)(C)CCl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0949

>  <W2 Pf proliferation inhibition EC50 uM>
0.1925

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.046296296

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3085
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    2.1434   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  3  1  0  0  0  0
  4  5  2  0  0  0  0
  6  5  1  4  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3085

>  <JC_XSMILES>
S=C(NN=CC=NNC(=S)NC1=CC=CC=C1)NC2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.036

>  <W2 Pf proliferation inhibition EC50 uM>
0.288

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.99

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3086
  Mrv1591402191617072D          

 19 19  0  0  0  0            999 V2000
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
  5 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
  2 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3086

>  <JC_XSMILES>
CC1=CC=C(OCCCCCCNCCO)C(C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.969

>  <W2 Pf proliferation inhibition EC50 uM>
0.391

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.36

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3088
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8871   -5.0906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7311   -5.9305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
  2 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3088

>  <JC_XSMILES>
CC(OC1=CC=C(Cl)C=C1Cl)C(=O)C2=CN(N=N2)C3=CC=C(C=C3)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0729

>  <W2 Pf proliferation inhibition EC50 uM>
0.192

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.012987013

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3089
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    8.0365    6.3525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5221    5.7075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8235    4.9395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3091    4.2945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6105    3.5266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0961    2.8815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2804    3.0045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9790    3.7725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4933    4.4175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1919    5.1855    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.7063    5.8305    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.3761    5.3084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7660    2.3595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0674    1.5915    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9502    2.4825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4358    1.8374    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7938    1.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6188    1.0941    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4358    0.3508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6315    0.1673    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9865    0.6816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720    0.2691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5575    0.6816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5575    1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720    1.9191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9865    1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6315    2.0210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4479    2.8253    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9502   -0.2942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6488   -1.0621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7660   -0.1712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
  7 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 16 27  1  0  0  0  0
 27 28  2  0  0  0  0
 19 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
M  CHG  2  10   1  11  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3089

>  <JC_XSMILES>
CCOC1=CC=C(C=C1[N+]([O-])=O)C(=O)CN2C(=O)C(OC3=CC=CC=C3C2=O)C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.919

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3091
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -2.1730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -3.6020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 13 10  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 16 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 14 32  1  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3091

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)S(=O)(=O)N=C2C=C(NC3=CC=C(O)C=C3)C(=O)C4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1578

>  <W2 Pf proliferation inhibition EC50 uM>
0.1352

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.05

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3093
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  7 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3093

>  <JC_XSMILES>
C=CCNC1=CC(=NC(=N1)C2=CC=CC=N2)C3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1252

>  <W2 Pf proliferation inhibition EC50 uM>
0.1915

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3095
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  6 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 12 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 11 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3095

>  <JC_XSMILES>
CCOC(=O)C1=C(CC)NC2=C(C1C3=CC=C(C=C3)N(C)C)C(=O)CCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
8.7

>  <W2 Pf proliferation inhibition EC50 uM>
1.911

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.014285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3100
  Mrv1591402191617072D          

 13 14  0  0  0  0            999 V2000
   -0.3867    8.9448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7222    8.1911    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2373    7.5236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5877    7.5236    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8426    6.7390    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1752    6.2541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1752    5.4291    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8897    5.0166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6041    5.4291    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8897    4.1916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3022    3.4771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4772    3.4771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4923    6.7390    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 12  1  0  0  0  0
  6 13  4  0  0  0  0
  3 13  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3100

>  <JC_XSMILES>
CSC1=NN=C(NC(=O)C2CC2)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.909

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3101
  Mrv1591402191617072D          

 45 50  0  0  0  0            999 V2000
    2.8889   -2.2672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3369   -2.8803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5084   -3.6873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7940   -4.0998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5164   -2.7940    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400   -4.0623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0470   -4.2338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5990   -3.6207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3441   -2.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4060   -3.7923    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5775   -2.9853    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2345   -4.5992    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2130   -3.9638    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4679   -4.7484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2749   -4.9199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6105   -5.6736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4309   -5.5874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6025   -4.7804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8880   -4.3679    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -5.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9681   -6.5147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7132   -7.2993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0938   -7.4708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6459   -6.8577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3909   -6.0731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 15 20  4  0  0  0  0
  8 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 24 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  2  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 32 36  1  0  0  0  0
  7 37  1  0  0  0  0
 37 38  2  0  0  0  0
 37 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 42 43  1  0  0  0  0
 43 44  1  0  0  0  0
 44 45  1  0  0  0  0
 40 45  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3101

>  <JC_XSMILES>
CC1=CC=C(O1)C(N(C(=O)CN2N=NC3=CC=CC=C23)C4=CC=C(C=C4)S(=O)(=O)NCC5CCCO5)C(=O)NC6CCCCC6

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.29

>  <W2 Pf proliferation inhibition EC50 uM>
1.906

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.018018018

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3103
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -6.7712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  8 12  4  0  0  0  0
  4 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
  6 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  4  0  0  0  0
 25 33  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  33
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3103

>  <JC_XSMILES>
CCOC1=CC(=CC(OCC)=C1OCC)C(=O)NC2=CC=C(C=C2)C3=NC4=CC=CC=C4N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2294

>  <W2 Pf proliferation inhibition EC50 uM>
0.763

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
40.05

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3107
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    4.5375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3184    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9684    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8867    5.7205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0703    6.5248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559    7.1698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309    7.1698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2165    6.5248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4001    5.7205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
  5 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
  2 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 30 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  2  0  0  0  0
 32 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 35 41  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3107

>  <JC_XSMILES>
O=C(CSC1=NC2=CC=CC=C2C(=O)N1CCCN3CCOCC3)NC4=CC=CC(=C4)S(=O)(=O)N5CCCCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.47

>  <W2 Pf proliferation inhibition EC50 uM>
1.176

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
62.08

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3108
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    7.1883    1.2701    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    6.3813    1.0986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.3140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.1425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0223    1.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8293    1.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 10 20  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3108

>  <JC_XSMILES>
BrC1=CC=C(C=C1)C2=CC3=C(N=N2)C4=CC=CC=C4C3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>2.499

>  <W2 Pf proliferation inhibition EC50 uM>
1.892

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3111
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  6  5  1  4  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  5 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
  2 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3111

>  <JC_XSMILES>
OC1=CC=C(C=NNC(=O)C2=CC=NC=C2)C(O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.75

>  <W2 Pf proliferation inhibition EC50 uM>
1.883

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027272727

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3114
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 11 20  4  0  0  0  0
  6 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3114

>  <JC_XSMILES>
COC1=CC=C2N=C(C)C=C(NC3=CC=C(Br)C=C3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2008

>  <W2 Pf proliferation inhibition EC50 uM>
0.369

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.68

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3118
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    3.2789    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769    2.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8220    3.2623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3740    3.8754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1810    3.7038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4359    2.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8839    2.3061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  8 16  4  0  0  0  0
 16 17  4  0  0  0  0
  6 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3118

>  <JC_XSMILES>
ClC1=NC=NC2=C1N(CC3=CC=CC=C3)C=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.647

>  <W2 Pf proliferation inhibition EC50 uM>
1.088

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
58.12

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3120
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    0.8212    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    3.1152    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    5.5902    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6548    1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9097    1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4248    0.3532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7347    1.0206    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9897    1.8053    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1298    2.0602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3848    2.8448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2098    2.8448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4647    2.0602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7973    1.5753    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2493    1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4209    0.9983    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8624    2.3573    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6470    2.1024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2601    2.6544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  6 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 14 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3120

>  <JC_XSMILES>
CCCC1=CC(=C(O)C=C1OC)C2=C(C(C)=NO2)C3=CC=C(O3)C(=O)OCC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.413

>  <W2 Pf proliferation inhibition EC50 uM>
0.346

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.53

>  <Powder data?>
Yes

>  <IFI value>
0.035087719

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3122
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    2.8579    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  4  2  1  4  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
  8 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3122

>  <JC_XSMILES>
OC(=O)C=CC(=O)N(C1CCCCC1)C2CCCCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.864

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3123
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 11 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
  9 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3123

>  <JC_XSMILES>
FC1=CC=CC=C1NC2=NC(NCC3CCCO3)=C4C=CC=CC4=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.669

>  <W2 Pf proliferation inhibition EC50 uM>
0.637

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
34.19

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3126
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 10 17  4  0  0  0  0
  5 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
  4 26  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3126

>  <JC_XSMILES>
CN(C)C1=C(N(C(C)=O)C2=CC(C)=CC(C)=C2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02299

>  <W2 Pf proliferation inhibition EC50 uM>
0.0415

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.23

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3127
  Mrv1591402191617072D          

 42 45  0  0  0  0            999 V2000
   -5.2241   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5096   -1.9441    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7951   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7951   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0807   -0.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3662   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3662   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6517   -1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9373   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2228   -1.9441    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -0.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -0.1923    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -0.3758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8843    0.2692    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7279   -1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5529   -1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9654   -0.4047    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -1.8624    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8843   -2.5075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5829   -3.2754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0973   -3.9204    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7671   -3.3984    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4657   -4.1664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6978   -3.8650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2337   -4.4678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1643   -4.9343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7001   -2.3845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0015   -1.6165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8173   -1.4936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3317   -2.1386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0303   -2.9065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5447   -3.5516    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3604   -3.4286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2145   -3.0295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -2.0460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3821   -2.8503    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0807   -1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
 22 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 34 37  4  0  0  0  0
 30 37  4  0  0  0  0
 21 38  1  0  0  0  0
 38 39  2  0  0  0  0
 38 40  1  0  0  0  0
 14 40  4  0  0  0  0
 40 41  4  0  0  0  0
 11 41  4  0  0  0  0
  7 42  4  0  0  0  0
  3 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3127

>  <JC_XSMILES>
COC1=CC=CC(CCOC2=CC=C3NC(=O)C(CO)N(C(C(=O)NC(C)(C)C)C4=CC=CC(OC)=C4)C(=O)C3=C2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1527

>  <W2 Pf proliferation inhibition EC50 uM>
0.1691

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>9.1

>  <Powder data?>
No

>  <IFI value>
0.022988506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3128
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
  5 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 17  1  0  0  0  0
 10 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3128

>  <JC_XSMILES>
CCCCN1CC2=CC=C(C=C2N=C1C3CC3)C(N)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.062

>  <W2 Pf proliferation inhibition EC50 uM>
0.2116

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.39

>  <Powder data?>
No

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3129
  Mrv1591402191617072D          

 43 49  0  0  0  0            999 V2000
    2.6563    1.2883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3238    0.8035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0774    1.1392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7449    0.6544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6588   -0.1661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9052   -0.5018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8191   -1.3223    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0655   -1.6580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3980   -1.1732    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9794   -2.4785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2458   -2.8748    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5093   -2.5030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8191   -2.9549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8654   -3.7786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1751   -4.2305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5613   -3.8588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2515   -4.3107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9880   -3.9389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0343   -3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3441   -2.6633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6076   -3.0350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0826   -2.5831    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3620   -3.6963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7836   -4.2847    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1880   -3.7987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7801   -4.3601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4155   -3.8372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1590   -2.8935    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6081   -3.0128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6455   -2.6845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1013   -3.4330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7511   -5.1846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0226   -5.5717    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4507   -5.6219    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1792   -5.2348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2082   -4.4103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9367   -4.0231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6362   -4.4604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6073   -5.2849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3068   -5.7223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8787   -5.6721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2377   -0.0170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4841   -0.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 13 22  1  0  0  0  0
 11 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 10 29  1  0  0  0  0
 25 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 27 31  1  0  0  0  0
 26 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  1  0  0  0  0
 39 41  4  0  0  0  0
 35 41  4  0  0  0  0
  6 42  1  0  0  0  0
  2 42  1  0  0  0  0
 42 43  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3129

>  <JC_XSMILES>
CC1CCCC(NC(=O)C2N(CC3COC4=CC=CC=C4O3)C(=O)C5C(C6OC25C=C6)C(=O)NC7=CC=CC(C)=C7)C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
>8.07

>  <W2 Pf proliferation inhibition EC50 uM>
1.857

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3131
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5395   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3131

>  <JC_XSMILES>
COC1=CC=CC(=C1)C2=NC3=C(OC)C=CC(OC)=C3C=C2CNCC(C)(C)CN(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2436

>  <W2 Pf proliferation inhibition EC50 uM>
0.1856

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.026086957

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3132
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    6.7206   -2.4814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9136   -2.6530    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3615   -2.0399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5546   -2.2114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0025   -1.5983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0645   -0.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6165   -1.2553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435   -1.1567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.7556    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0223    1.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4703    2.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8293    1.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 15 21  1  0  0  0  0
 13 22  4  0  0  0  0
 22 23  4  0  0  0  0
  9 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3132

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2C(=O)C3=C(SC4=C3CCN(C)C4)N=C2SC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
2.209

>  <W2 Pf proliferation inhibition EC50 uM>
1.853

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3133
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -4.2295   -5.8403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8939   -5.0866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0735   -5.0004    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3789   -4.4192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0433   -3.6655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5282   -2.9981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1927   -2.2444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3722   -2.1582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8873   -2.8256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2228   -3.5793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0366   -1.4045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4491   -0.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8971   -0.0769    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5082    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2297   -1.2330    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  1  0  0  0  0
 22 24  1  0  0  0  0
 18 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
 14 28  4  0  0  0  0
 11 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3133

>  <JC_XSMILES>
CC(C)CC1=CC=C(C=C1)C2=CSC(NC(=O)C3C4CCC(C4)C3C(O)=O)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.772

>  <W2 Pf proliferation inhibition EC50 uM>
1.853

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046511628

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3134
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    5.8161   -3.1594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5306   -3.5719    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2450   -3.1594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2450   -2.3344    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9595   -3.5719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6740   -3.1594    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.3884   -3.5719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1029   -3.1594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8174   -3.5719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8174   -4.3969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1029   -4.8094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3884   -4.3969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5319   -4.8094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5319   -5.6344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1993   -6.1193    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.9444   -6.9040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1194   -6.9040    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.8644   -6.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0798   -5.8644    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.4293   -7.5714    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.0937   -8.3251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5786   -8.9925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2431   -9.7462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4226   -9.8324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0871  -10.5861    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.9377   -9.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2732   -8.4113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 13 10  1  4  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  2  0  0  0  0
 16 20  2  0  0  0  0
 20 21  1  4  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3134

>  <JC_XSMILES>
COC(=O)COC1=CC=C(C=C1)C=C2SC(NC2=O)=NC3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.848

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3135
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -0.7448   -1.1616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7448   -1.9866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0303   -2.3991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0303   -3.2241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7448   -3.6366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7448   -4.4616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0774   -4.9465    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -5.7311    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1573   -5.7311    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4123   -4.9465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1969   -4.6916    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8100   -5.2436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5946   -4.9886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2620   -5.4736    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9295   -4.9886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6745   -4.2040    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8495   -4.2040    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7141   -5.2436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8856   -6.0506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6702   -6.3055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2833   -5.7535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1118   -4.9465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3272   -4.6916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7249   -4.3945    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -8.5095   -4.6494    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -7.5534   -3.5875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4593   -3.2241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1738   -3.6366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4593   -2.3991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
  5 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
  2 29  4  0  0  0  0
M  CHG  2  24   1  25  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3135

>  <JC_XSMILES>
CC1=CC=C(N2N=NN=C2SCC3=NC(=NO3)C4=CC=CC(=C4)[N+]([O-])=O)C(C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>4.69

>  <W2 Pf proliferation inhibition EC50 uM>
1.846

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015037594

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3139
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.1486    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   22.1486    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.8631    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.8631   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   23.5775   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   22.1486   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 17 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3139

>  <JC_XSMILES>
CCCCCCCCC(=O)N(C)CCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.321

>  <W2 Pf proliferation inhibition EC50 uM>
0.1961

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.7

>  <Powder data?>
No

>  <IFI value>
0.053763441

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3140
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.6021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    3.8396    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 12 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 10 28  4  0  0  0  0
 28 29  4  0  0  0  0
  8 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3140

>  <JC_XSMILES>
CC1=CC=CC(=C1)C2=NC3=CC(NC(=S)NC(=O)C4=CC=C(Cl)C=C4)=CC=C3O2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.658

>  <W2 Pf proliferation inhibition EC50 uM>
0.1832

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3141
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    2.6246    2.0710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8399    1.8160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6684    1.0091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6288    1.5387    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0992    0.4992    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919   -4.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2337    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 14 24  4  0  0  0  0
  7 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  2  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 11 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3141

>  <JC_XSMILES>
CCCS(=O)(=O)C1=C2C=CC(=CN2C(C(=O)C3=CC=C(C)C=C3)=C1S(=O)(=O)CCC)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.832

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3142
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
    5.6452   -1.9463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3597   -2.3588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0742   -1.9463    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7886   -2.3588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7886   -3.1838    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5031   -1.9463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2176   -2.3588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9320   -1.9463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9320   -1.1213    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.6465   -2.3588    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.3610   -1.9463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4472   -1.1258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2542   -0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6667   -1.6687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1147   -2.2818    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.2862   -3.0888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0708   -3.3437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2423   -4.1507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6292   -4.7027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8008   -5.5097    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   11.8446   -4.4478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2315   -4.9998    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   11.6731   -3.6408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5897   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9253    0.5531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3434   -0.5361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8361    0.1350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 16 23  4  0  0  0  0
 13 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3142

>  <JC_XSMILES>
CCOC(=O)CCC(=O)OC1=CC(=NN1C2=CC=C(Cl)C(Cl)=C2)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.232

>  <W2 Pf proliferation inhibition EC50 uM>
0.2033

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.1

>  <Powder data?>
No

>  <IFI value>
0.063636364

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3143
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -1.5356    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    6.0027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041    3.0428    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341    1.5907    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242    2.2581    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393    1.5907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3942    0.8061    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7268    0.3212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0593    0.8061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3143    1.5907    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693    3.0428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846    3.2977    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
 10  7  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 15 21  1  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3143

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)C=C2SC(=N)N(C3=NC=CS3)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
5.05

>  <W2 Pf proliferation inhibition EC50 uM>
1.829

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3144
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 12 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3144

>  <JC_XSMILES>
CCN1CCC(CC1)NCCC(C2=CC=CC=C2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2802

>  <W2 Pf proliferation inhibition EC50 uM>
0.066

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.61

>  <Powder data?>
Yes

>  <IFI value>
0.040983607

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3149
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3260   -1.5731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8781   -0.9600    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4656   -0.2455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6586   -0.4170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
  4 13  4  0  0  0  0
  2 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3149

>  <JC_XSMILES>
O=C(NC1=CN=C2C=CC=CC2=C1)C3=CC=CC(=C3)N4C=NN=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1737

>  <W2 Pf proliferation inhibition EC50 uM>
0.1821

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.072072072

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-315
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8449   -2.3738    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6518   -2.5453    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2649   -1.9933    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.7381   -3.3658    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4526   -3.7783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1670   -3.3658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8815   -3.7783    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1670   -2.5408    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9844   -3.7013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8129   -4.5083    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  5  4  1  4  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
 10 15  1  0  0  0  0
  6 15  1  0  0  0  0
 15 16  2  0  0  0  0
  4 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
  2 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-315

>  <JC_XSMILES>
CC1=CC(C=C2SC(=S)N(CC(O)=O)C2=O)=C(C)N1C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
8.22

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>78.15

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3150
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5408   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 11 13  1  0  0  0  0
  7 14  4  0  0  0  0
 14 15  4  0  0  0  0
  4 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
  2 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3150

>  <JC_XSMILES>
CC1=NC2=CC=C(NC(=O)C3CC3)C=C2C(=O)N1CC4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.171

>  <W2 Pf proliferation inhibition EC50 uM>
1.82

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.033898305

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3151
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    7.2432    5.6439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5446    4.8759    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.0302    4.2309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3316    3.4629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8172    2.8179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0015    2.9409    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4871    2.2958    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6713    2.4188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3699    3.1868    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1569    1.7738    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5149    1.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1569    0.2872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3526    0.1036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7076    0.6180    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9230    0.3631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4380    1.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9230    1.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7076    1.4430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3526    1.9574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1690    2.7617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3807    3.0049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1971    3.8092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8019    4.3703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5902    4.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7738    3.3228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6183    5.1746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4347    5.9789    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4226    5.3582    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8140    4.9911    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7001    3.7088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2144    4.3538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 18 19  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
  6 30  4  0  0  0  0
 30 31  4  0  0  0  0
  3 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3151

>  <JC_XSMILES>
CSC1=CC=C(NC(=O)N2CCCN3C=CC=C3C2C4=CC=C(C=C4)C(F)(F)F)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
3.99

>  <W2 Pf proliferation inhibition EC50 uM>
1.812

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.028301887

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3152
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0223   -0.7152    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4703   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1732   -2.7260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4281   -3.5106    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8761   -4.1237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1310   -4.9083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3860   -5.6929    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3662   -2.5545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8142   -3.1676    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0072   -2.9960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1113   -1.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -1.5105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  3  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 12 23  4  0  0  0  0
 10 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
  9 31  1  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3152

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=C(OCC#N)C(OC)=C3)C(=O)C4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.59

>  <W2 Pf proliferation inhibition EC50 uM>
1.534

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
84.91

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3156
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 13 26  4  0  0  0  0
 21 26  4  0  0  0  0
 11 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3156

>  <JC_XSMILES>
CC1CCCCN1CCCN(CC2=C3C=CC=CC3=CC4=CC=CC=C24)C(=O)C5=CC=CC=C5Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.878

>  <W2 Pf proliferation inhibition EC50 uM>
0.03125

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>1.736

>  <Powder data?>
No

>  <IFI value>
0.020833333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3157
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -3.5479    5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1354    4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4710    3.8520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3149    4.5195    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
  8 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 21 25  4  0  0  0  0
  4 25  4  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3157

>  <JC_XSMILES>
CC1=CC2=C(S1)N=C(SCC(=O)NC3=CC=CC=C3C)N(CC=C)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
4.28

>  <W2 Pf proliferation inhibition EC50 uM>
1.796

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-316
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 27 28  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-316

>  <JC_XSMILES>
CCCN1CCN(CC1)C(=O)CCNC(=O)CN2C=NC3=CC=CC=C3C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.593

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.011904762

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3161
  Mrv1591402191617072D          

 14 15  0  0  0  0            999 V2000
    0.7145    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  3  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3161

>  <JC_XSMILES>
N#CC1=CC=CC=C1N2CCCCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
>10.8

>  <W2 Pf proliferation inhibition EC50 uM>
1.793

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046296296

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3163
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3260   -5.0269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8781   -5.6400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4656   -6.3545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6586   -6.1830    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 10 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
  6 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3163

>  <JC_XSMILES>
CC1=CC(C)=C(NC(=S)N(CCCN2CCCCC2)CC3=CC=CS3)C(C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.535

>  <W2 Pf proliferation inhibition EC50 uM>
0.1792

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3164
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -5.4349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -6.2195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -6.2195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -5.4349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4521   -5.1800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0652   -5.7320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8498   -5.4771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0213   -4.6701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4082   -4.1181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6236   -4.3730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
  2 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 20 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3164

>  <JC_XSMILES>
O=C(C1CCN(CC1)C2=NN=NN2C3=CC=CC=C3)N4CCC5=CC=CC=C5C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.298

>  <W2 Pf proliferation inhibition EC50 uM>
1.792

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3168
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.5395   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
  7 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 17 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  CHG  1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3168

>  <JC_XSMILES>
C[N+](C)(C)C1=NC(=NC(=N1)N2CCOCC2)N(C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0632

>  <W2 Pf proliferation inhibition EC50 uM>
0.1786

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.024096386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3169
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -0.3311    1.7545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9442    1.2025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580    0.3820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6117    0.0464    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8666   -0.7382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6736   -0.9097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2256   -0.2966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9707    0.4880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1637    0.6595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7512    1.3740    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1073    0.7555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
  2 10  4  0  0  0  0
  3 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 11 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3169

>  <JC_XSMILES>
CC1=C(N2C=CC=CC2=N1)C3(O)C(=O)NC4=C3C=C(Cl)C=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.449

>  <W2 Pf proliferation inhibition EC50 uM>
0.1785

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.09375

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3170
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
  2 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   3
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3170

>  <JC_XSMILES>
CC1=NC2=CC=C(Br)C=C2C(O)=C1CC=C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.605

>  <W2 Pf proliferation inhibition EC50 uM>
1.785

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3173
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3173

>  <JC_XSMILES>
CC(CC1=CC=CC=C1)NCCCCCCCNC(C)CC2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2675

>  <W2 Pf proliferation inhibition EC50 uM>
0.105

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.9

>  <Powder data?>
Yes

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3174
  Mrv1591402191617072D          

 16 18  0  0  0  0            999 V2000
    0.7145   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  2  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  5 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3174

>  <JC_XSMILES>
ClC1=CC=C2C(=O)C3=CC=CC=C3NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0955

>  <W2 Pf proliferation inhibition EC50 uM>
0.1779

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.027027027

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3175
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
   -3.4656   -6.2491    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -5.0116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -7.4866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6548   -7.9715    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9097   -8.7562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7347   -8.7562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9897   -7.9715    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -4.1866    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235   -2.9491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4669   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4669   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4199    0.0108    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1650    0.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3400    0.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0850    0.0108    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
  2 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 28 30  1  0  0  0  0
 30 31  2  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 30 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3175

>  <JC_XSMILES>
O=C(NC1=CC=CC(=C1)C2=NCCN2)C3=CC=C(C=C3)C(=O)NC4=CC=CC(=C4)C5=NCCN5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.599

>  <W2 Pf proliferation inhibition EC50 uM>
0.1778

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008928571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-318
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    4.0668    2.3479    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -0.5422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -0.3707    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -1.9399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -2.7246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -2.8961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -2.2830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -1.4984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
  2 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-318

>  <JC_XSMILES>
ClC1=CC=C2N(CC(=O)C3=CC=CC=C3)C(=O)OC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
28.39

>  <Powder data?>
Yes

>  <IFI value>
0.015151515

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3180
  Mrv1591402191617072D          

 37 42  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5690    1.6002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0993    0.6817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0714    3.5549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5564    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0714    2.2201    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8125    0.6817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2822    1.6002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
  9 16  1  0  0  0  0
 16 17  2  0  0  0  0
 10 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
 18 29  1  0  0  0  0
 29 30  2  0  0  0  0
  8 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 34 37  1  0  0  0  0
 29 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3180

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2C3=C(CC(C)(C)CC3=O)N(CC4=CC=C5OCOC5=C4)C6=C2C(=O)CC(C)(C)C6

>  <PF proliferation inhibition 3D7 EC50 uM>
3.75

>  <W2 Pf proliferation inhibition EC50 uM>
1.773

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3182
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1773   -2.3166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  2 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3182

>  <JC_XSMILES>
CN1C(SCC=C)=NC=C1C2=CC=C(Cl)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.768

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.010752688

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3184
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    8.0289    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2039    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7914   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9664   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5539   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7289   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3164   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7289   -2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4914   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2211   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6336   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4586   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8711    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6961    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4914   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3164   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7289    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  2  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 21  4  0  0  0  0
 21 22  2  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  6 27  4  0  0  0  0
 27 28  2  0  0  0  0
 26 29  4  0  0  0  0
  9 29  4  0  0  0  0
 29 30  4  0  0  0  0
 12 30  4  0  0  0  0
 23 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3184

>  <JC_XSMILES>
OCCCCN1C(=O)C2=CC=C3C(=O)N(CCCCO)C(=O)C4=CC=C(C1=O)C2=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.354

>  <W2 Pf proliferation inhibition EC50 uM>
0.0774

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.38

>  <Powder data?>
Yes

>  <IFI value>
0.112903226

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3185
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    7.7487   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9862   -0.9355    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7487   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8112   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2237   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0487   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4612   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2862   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6987   -3.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2862   -3.7934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6987   -4.5079    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5237   -4.5079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9362   -3.7934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7612   -3.7934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.1737   -4.5079    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.7612   -5.2224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.1737   -5.9368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7612   -6.6513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.1737   -7.3658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7612   -8.0802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9362   -8.0802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5237   -7.3658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9362   -6.6513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5237   -5.9368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9362   -5.2224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4612   -3.7934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0487   -3.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 14 27  4  0  0  0  0
 18 27  4  0  0  0  0
 12 28  4  0  0  0  0
 28 29  4  0  0  0  0
  9 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3185

>  <JC_XSMILES>
CCN(CC)CCNC1=CC=C(NC2=CC=NC3=CC4=CC=CC=C4C=C23)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02818

>  <W2 Pf proliferation inhibition EC50 uM>
0.0417

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.36

>  <Powder data?>
Yes

>  <IFI value>
0.171875

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3188
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -2.7512    8.8902    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    7.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    6.4152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    7.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    5.5902    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5762    5.5902    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9262    5.5902    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    1.8777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    1.8777    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.1848    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6548   -0.6697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9097   -1.4544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7347   -1.4544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9897   -0.6697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 22 26  1  0  0  0  0
 20 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3188

>  <JC_XSMILES>
ClC1=CC=C(C=C1)S(=O)(=O)N2CCC(CC2)C(=O)NC(CN3CCCC3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1605

>  <W2 Pf proliferation inhibition EC50 uM>
0.648

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
36.81

>  <Powder data?>
Yes

>  <IFI value>
0.019417476

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-319
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 14 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
 12 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-319

>  <JC_XSMILES>
CC1CCN(CC1)C(=O)CSC2=NC(NCC3=CC=CC=C3)=C4C=CC=CC4=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.673

>  <W2 Pf proliferation inhibition EC50 uM>
>1.582

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3190
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
    3.2789    2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4539    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.1039    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2426    1.1270    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    2.5559    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051    4.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    4.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4615   -0.0769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0136   -0.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6011   -1.4045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7941   -1.2330    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  5 13  4  0  0  0  0
  9 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
  7 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 32 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3190

>  <JC_XSMILES>
FC(F)(F)C1=CC(=NC2=CC(=NN12)C(=O)NC3=CC=C(Br)C=C3C(=O)C4=CC=CC=C4)C5=CC=CS5

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.757

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3193
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -2.8407   -3.0788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0202   -3.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4681   -2.5519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007   -3.7080    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6077   -3.8795    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
  7 13  4  0  0  0  0
  6 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 14 23  4  0  0  0  0
 23 24  1  0  0  0  0
  4 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3193

>  <JC_XSMILES>
CC1=CC(NC(C2=CC=CC(Br)=C2)C3=CC=C4C=CC=NC4=C3O)=NO1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2672

>  <W2 Pf proliferation inhibition EC50 uM>
0.4

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>22.84

>  <Powder data?>
Yes

>  <IFI value>
0.043478261

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3195
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
  5 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  3 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
  7 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 34 35  4  0  0  0  0
 26 35  4  0  0  0  0
 35 36  4  0  0  0  0
 22 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3195

>  <JC_XSMILES>
COC1=CC2=NC(=NC(N)=C2C=C1OC)N3CCN(CC3)C4=NC(N)=C5C=C(OC)C(OC)=CC5=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0911

>  <W2 Pf proliferation inhibition EC50 uM>
0.2569

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.69

>  <Powder data?>
Yes

>  <IFI value>
0.230769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-320
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-320

>  <JC_XSMILES>
COC1=CC=CC=C1C(=O)NNC(=O)C2=CC=CC=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.711

>  <W2 Pf proliferation inhibition EC50 uM>
1.376

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.7

>  <Powder data?>
Yes

>  <IFI value>
0.121212121

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3203
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    3.5724   -7.8375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 16 21  4  0  0  0  0
 14 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 22 26  1  0  0  0  0
  7 27  4  0  0  0  0
 27 28  4  0  0  0  0
  4 28  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3203

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(NCCNC2=NC(=NC3=CC=CC=C23)N4CCCC4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.564

>  <W2 Pf proliferation inhibition EC50 uM>
0.334

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.24

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3204
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2487    3.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007    4.2631    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3882    4.9775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6431    5.7621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0911    6.3752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7159    6.2037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9708    5.4191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4188    4.8060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  4 12  4  0  0  0  0
  7 12  4  0  0  0  0
  2 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 14 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3204

>  <JC_XSMILES>
OC(CN1N=NC2=CC=CC=C12)CN3C4=CC=C(Br)C=C4C5=CC(Br)=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
3.37

>  <W2 Pf proliferation inhibition EC50 uM>
1.354

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>78.03

>  <Powder data?>
Yes

>  <IFI value>
0.020134228

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3207
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -3.7447   -3.3756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0302   -2.9631    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0302   -2.1381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3157   -3.3756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6013   -2.9631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8868   -3.3756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1723   -2.9631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5421   -3.3756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5421   -4.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2566   -4.6131    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9711   -4.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6856   -4.6131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9711   -3.3756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2566   -2.9631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4281   -2.1561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9432   -1.4887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2788   -0.7350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0993   -0.6488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5842   -1.3162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2486   -2.0699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5842   -2.8235    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3207

>  <JC_XSMILES>
CN(C)CCCCC1=CN=C(C)C2=C1C3=CC=CC=C3N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.472

>  <W2 Pf proliferation inhibition EC50 uM>
0.325

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.75

>  <Powder data?>
Yes

>  <IFI value>
0.111111111

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3209
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
   -3.1034   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.6021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 20 28  4  0  0  0  0
 16 28  4  0  0  0  0
 10 29  4  0  0  0  0
  7 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3209

>  <JC_XSMILES>
C1CCN(CC1)C2=NC3=C(CN(CC3)CC4=CC=CC(OC5=CC=CC=C5)=C4)S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2937

>  <W2 Pf proliferation inhibition EC50 uM>
0.1731

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.183098592

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3211
  Mrv1591402191617072D          

 22 22  0  0  0  0            999 V2000
   -1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
  6 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
M  CHG  2  15   1  16  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3211

>  <JC_XSMILES>
CCOC(=O)C(=CNC1=CC=CC=C1[N+]([O-])=O)C(=O)OCC

>  <PF proliferation inhibition 3D7 EC50 uM>
7.99

>  <W2 Pf proliferation inhibition EC50 uM>
1.73

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3212
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3212

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)CC(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2364

>  <W2 Pf proliferation inhibition EC50 uM>
0.173

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.074766355

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3214
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.8018   -4.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498   -4.0609    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6707    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2227    3.6495    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.9256    2.2518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7326    2.0803    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 13 20  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 25  4  0  0  0  0
 21 25  4  0  0  0  0
M  CHG  1  11   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3214

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C[N+](CC3=CC=C(Cl)C(Cl)=C3)=C4CCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.537

>  <W2 Pf proliferation inhibition EC50 uM>
0.858

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
49.66

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3218
  Mrv1591402191617072D          

 35 37  0  0  0  0            999 V2000
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4694   -1.3144    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0215   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6090   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8020   -2.4705    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  9 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 24 28  4  0  0  0  0
  8 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3218

>  <JC_XSMILES>
COCCNC(=O)C(N(CC1=CC=CC=C1)C(=O)CCC(=O)NC2=NC=CS2)C3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>4.59

>  <W2 Pf proliferation inhibition EC50 uM>
1.717

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.113207547

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3220
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
   -1.1129   -0.4834    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3429   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -2.6029    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0263    0.1995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2286    0.9841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0536    0.9841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3086    0.1995    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1679   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5804   -1.2210    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5804   -2.6499    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4054   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8179   -3.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6429   -3.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0554   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8804   -2.6499    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6429   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8179   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 13 19  4  0  0  0  0
  2 19  4  0  0  0  0
  5 19  4  0  0  0  0
  3 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3220

>  <JC_XSMILES>
NC1=C(SC2=NC3=C(CCCC3)C(C4=CC=CS4)=C12)C(=O)NC5=CC=C(F)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.134

>  <W2 Pf proliferation inhibition EC50 uM>
1.713

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3223
  Mrv1591402191617072D          

 39 44  0  0  0  0            999 V2000
    1.3073   -3.8868    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.5788   -3.4996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1207   -3.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8492   -3.5498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5488   -3.9871    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.8782   -2.7253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1787   -2.2880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2076   -1.4635    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4919   -1.0261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2204   -1.4133    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4629   -0.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1725    0.3212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0841    1.2649    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6349    1.1456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4025    1.4739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8583    0.7254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0550    0.3597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8811    0.4621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4594   -0.1263    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9973    1.2836    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7337    1.6554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7800    2.4791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5165    2.8509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5627    3.6746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2992    4.0464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9894    3.5945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9432    2.7708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2067    2.3990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2637    1.6800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1776    2.5005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8451    2.9853    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4239    2.8361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3378    3.6566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4158    3.9923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5019    4.8128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1656    5.2976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9193    4.9619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0054    4.1414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5498   -2.6751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 20 29  1  0  0  0  0
 14 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 33 38  1  0  0  0  0
  7 39  4  0  0  0  0
  2 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3223

>  <JC_XSMILES>
ClC1=CC(Cl)=CC(NC(=O)C2C3OC4(C=C3)C2C(=O)N(CCC5=CCCCC5)C4C(=O)NC6CCCCC6)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.03

>  <W2 Pf proliferation inhibition EC50 uM>
1.711

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.021276596

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3224
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -0.1006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 13 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  4  0  0  0  0
  9 27  4  0  0  0  0
 27 28  4  0  0  0  0
  6 28  4  0  0  0  0
M  CHG  1  24   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3224

>  <JC_XSMILES>
CCOC(=O)C1=CC=C2N(CC)C(\C=C\N(C)C3=CC=CC=C3)=[N+](CC)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2724

>  <W2 Pf proliferation inhibition EC50 uM>
0.588

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
34.39

>  <Powder data?>
Yes

>  <IFI value>
0.074074074

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3227
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    0.6077    1.1758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7633    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2992    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7042   -1.7841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4888   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1019   -2.0811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8865   -1.8261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0580   -1.0192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4449   -0.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6603   -0.7221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0472   -0.1701    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.2222   -0.1701    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.2187    0.6369    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4493   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6243   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1394   -3.2362    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5847   -1.5292    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9342   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7547   -3.1499    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5987   -3.9898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0836   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7481   -5.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9276   -5.4972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4427   -4.8298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7782   -4.0761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
  6 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
  5 19  1  0  0  0  0
 19 20  2  0  0  0  0
 16 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  CHG  2  13   1  14  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3227

>  <JC_XSMILES>
COCCN1C(C2=CC=CC=C2[N+]([O-])=O)C(=C(O)C1=O)C(=O)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.706

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3228
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    3.6829   -3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  4 17  4  0  0  0  0
  8 17  4  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3228

>  <JC_XSMILES>
CCC[N+]1=CC=CC2=CC=C3C=CC=NC3=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2097

>  <W2 Pf proliferation inhibition EC50 uM>
0.756

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
44.33

>  <Powder data?>
Yes

>  <IFI value>
0.015873016

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3230
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6081   -2.8265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4366   -3.6335    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8011   -2.6550    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4151   -2.9980    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  7 26  4  0  0  0  0
  3 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3230

>  <JC_XSMILES>
CCC1=CC=CC(NC(=S)N2CCCC2C3=CC=CC=C3C(F)(F)F)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.408

>  <W2 Pf proliferation inhibition EC50 uM>
0.1696

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3232
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6207   -4.8776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8756   -4.0930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7006   -4.0930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9556   -4.8776    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 13 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3232

>  <JC_XSMILES>
COC(=O)NCCNC(=O)COC(C1=CC=CS1)C2=CC=CN=C2Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.185

>  <W2 Pf proliferation inhibition EC50 uM>
0.1695

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019417476

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3236
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3236

>  <JC_XSMILES>
CC(C)C(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=NC=CC(C)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
>6.15

>  <W2 Pf proliferation inhibition EC50 uM>
1.693

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3238
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    2.5559   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -4.1974    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 10 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  8 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3238

>  <JC_XSMILES>
C1COC(C1)CNC2=NC(NC3=CC=CC=C3)=NC4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1142

>  <W2 Pf proliferation inhibition EC50 uM>
0.169

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3240
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  2 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 12 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3240

>  <JC_XSMILES>
OC(CNC1CCCCC1)CN2C3=CC=C(Br)C=C3C4=CC(Br)=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.451

>  <W2 Pf proliferation inhibition EC50 uM>
0.1018

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.06

>  <Powder data?>
No

>  <IFI value>
0.053030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3241
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4760   -4.1974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309   -4.9820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559   -4.9820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8109   -4.1974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5955   -3.9425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2086   -4.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0370   -5.3015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6501   -5.8535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4348   -5.5986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6063   -4.7916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9932   -4.2396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
  3 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 20 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3241

>  <JC_XSMILES>
C1CN(CCN1CC2=NN=NN2CC3=CC=CC=C3)C(C4=CC=CC=C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
2.866

>  <W2 Pf proliferation inhibition EC50 uM>
1.673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3244
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 10 19  1  0  0  0  0
 11 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  CHG  1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3244

>  <JC_XSMILES>
C[N+]1=CC=CC=C1\C=C\C2=C(OC3=CC=CC=C3O2)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1333

>  <W2 Pf proliferation inhibition EC50 uM>
0.2493

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.94

>  <Powder data?>
Yes

>  <IFI value>
0.111111111

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3246
  Mrv1591402191617072D          

 42 45  0  0  0  0            999 V2000
   10.2311    0.2760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9456    0.6885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6601    0.2760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3746    0.6885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0890    0.2760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.8035    0.6884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.5180    0.2759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2324    0.6884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2325    1.5134    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.9469    0.2759    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   16.6614    0.6884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.3758    0.2759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.3758   -0.5491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   16.6613   -0.9616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.9469   -0.5491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.1001   -0.9394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.0246   -1.7883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.8965   -1.8877    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   18.3726   -2.6344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.0902   -3.4366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.6273   -4.0629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.3534   -4.8411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.5425   -4.9931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.2686   -5.7713    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   17.0055   -4.3668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.2794   -3.5886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.7229   -1.4720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.7032   -0.6109    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   20.4334   -2.0057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.0465   -1.4537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.0689   -0.5734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.7610   -1.8662    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   21.5894   -2.6732    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   20.7689   -2.7594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.3564   -3.4739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.7689   -4.1884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.5782   -4.4322    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   20.3564   -4.9028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.5314   -4.9028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.1189   -4.1883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.5314   -3.4739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2339   -2.5947    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 18 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  1  0  0  0  0
 36 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 35 41  4  0  0  0  0
 41 42  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3246

>  <JC_XSMILES>
CCCCCCCC(=O)N1CCN(CC1)CCN(CC2=CC=C(F)C=C2)C(=O)C3=C(C)ON=C3C4=C(F)C=CC=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
1.761

>  <W2 Pf proliferation inhibition EC50 uM>
1.665

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.048076923

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3247
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    5.1558   -4.1558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3308   -4.1558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9183   -4.8702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9183   -3.4413    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0933   -3.4413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6808   -2.7268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8558   -2.7268    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4433   -2.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8558   -1.2979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4433   -0.5834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6183   -0.5834    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2058   -1.2979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6183   -2.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0663   -2.6254    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6874   -2.2899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4410   -2.6254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1085   -2.1405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0222   -1.3200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6897   -0.8351    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.2686   -0.9845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6011   -1.4694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3308   -2.7268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9183   -2.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1558   -2.7268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 15 21  4  0  0  0  0
  4 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3247

>  <JC_XSMILES>
CC(C)N(CCNC1=NC=NC2=C1NC3=CC=C(Cl)C=C23)C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2617

>  <W2 Pf proliferation inhibition EC50 uM>
0.2525

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.18

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3248
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    6.3423    3.9604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6779    3.2067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4983    3.1204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9833    3.7879    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7283    4.5725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3958    5.0574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0632    4.5725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8083    3.7879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1929    2.5392    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3725    2.6255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8204    2.0124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1530    3.1684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9600    3.3400    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0992    0.3258    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6684   -0.1841    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6288   -0.7137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9259   -2.1115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -2.2830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4331   -1.6699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -0.8853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  2  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
 19 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3248

>  <JC_XSMILES>
O=C(CN1CCCC1)NC2=NC(=CS2)C3=CC=C4N(CCC4=C3)S(=O)(=O)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.468

>  <W2 Pf proliferation inhibition EC50 uM>
1.266

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>76.15

>  <Powder data?>
Yes

>  <IFI value>
0.052631579

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3249
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
  5 15  1  0  0  0  0
 15 16  2  0  0  0  0
  6 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
  3 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3249

>  <JC_XSMILES>
COC1=CC2=C(C(=O)C3=CC=CC=C3C2=O)C(OC)=C1CN4CCN(CC4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1305

>  <W2 Pf proliferation inhibition EC50 uM>
0.166

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-325
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 21 22  1  0  0  0  0
 11 23  4  0  0  0  0
 23 24  4  0  0  0  0
  8 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-325

>  <JC_XSMILES>
CC(C)CNC(=O)C1=CN=C(NCCCN2CCCCC2C)N=C1NCCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.374

>  <W2 Pf proliferation inhibition EC50 uM>
1.571

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3254
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5700    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
  5 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 14 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 13 29  1  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3254

>  <JC_XSMILES>
CC(=O)N(C1=CC=C(F)C(F)=C1)C2=C(N3CCOCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0743

>  <W2 Pf proliferation inhibition EC50 uM>
0.0575

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.48

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3256
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.7771    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    4.3727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    4.8143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    4.0297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    3.4166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
  7 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 17 25  4  0  0  0  0
 14 25  4  0  0  0  0
 25 26  4  0  0  0  0
  5 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3256

>  <JC_XSMILES>
CC(C)CC1=NC(N2CCOCC2)=C3N=NN(CC4=CC=CC=C4)C3=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
3.029

>  <W2 Pf proliferation inhibition EC50 uM>
1.65

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3259
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
  9 16  4  0  0  0  0
  7 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  5 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3259

>  <JC_XSMILES>
OCCNC1=NC(NC2=CC=C(Cl)C(Cl)=C2)=NC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1399

>  <W2 Pf proliferation inhibition EC50 uM>
0.1544

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.4

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3263
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -3.5854    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 18 24  4  0  0  0  0
 15 25  4  0  0  0  0
 25 26  4  0  0  0  0
  9 26  4  0  0  0  0
 12 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3263

>  <JC_XSMILES>
COC1=CC=C(C=N1)C2=CN=C3C=CC(NCC4=CC=CC(Cl)=C4)=NN23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.805

>  <W2 Pf proliferation inhibition EC50 uM>
1.13

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
68.93

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3267
  Mrv1591402191617072D          

 35 36  0  0  1  0            999 V2000
    7.8352    2.9259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5349    2.1575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0503    1.5133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7193    2.0333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4191    1.2648    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.1083    0.8114    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5536    0.1168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3255    0.4079    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6778   -0.6987    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    8.5014   -0.7468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8716   -1.4841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6952   -1.5322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4181   -2.1733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4595   -1.4944    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9366   -2.1324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4519   -2.7766    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1993   -2.5026    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.3751   -2.5409    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6067   -2.2407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1533   -2.9299    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0268   -1.6538    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.2032   -1.6058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6548   -0.9894    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7029   -0.1658    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3193    0.3826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1429    0.3345    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.8069    1.1899    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6051    1.3987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5668    2.2228    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6912   -0.2819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4705   -0.0111    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6432   -1.1055    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4081   -3.3007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8212   -3.8806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2037   -3.5190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  4  1  6  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  9  7  1  0  0  0  0
  9 10  1  1  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 17 15  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 21 19  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 26 25  1  1  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
  5 28  1  0  0  0  0
 28 29  2  0  0  0  0
 26 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 21 32  1  1  0  0  0
 17 33  1  6  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3267

>  <JC_XSMILES>
CC(C)C[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H]2CSSC[C@@H](NC1=O)C(=O)N2)C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.1636

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.259259259

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-327
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -0.7930    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0320    3.9849    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4445    4.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4445    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4445    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0320    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    1.8414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195   -1.0164    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
 16 17  1  0  0  0  0
 10 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-327

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)N2C(N)=NC(N)=NC23CCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2437

>  <W2 Pf proliferation inhibition EC50 uM>
>1.568

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3270
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.8212    1.1759    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212   -0.4741    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5986   -3.9898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7479   -5.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9275   -5.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4425   -4.8297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7781   -4.0760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  9  5  1  4  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  2  0  0  0  0
 12 16  2  0  0  0  0
 16 17  1  4  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3270

>  <JC_XSMILES>
FC1=CC=C(C=C1Br)C=C2SC(NC2=O)=NC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.633

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3273
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 13 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3273

>  <JC_XSMILES>
CC(C)CC(=O)N(C)CCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.74

>  <W2 Pf proliferation inhibition EC50 uM>
0.1214

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.44

>  <Powder data?>
No

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3274
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    2.4856   -3.3002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3106   -3.3002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7231   -4.0147    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3106   -4.7291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4856   -4.7291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5481   -4.0147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9606   -4.7291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7856   -4.7291    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1981   -5.4436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7856   -6.1581    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1981   -6.8726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0231   -6.8726    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4356   -6.1581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0231   -5.4436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5751   -4.8305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3288   -5.1661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0825   -4.8305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7499   -5.3154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6637   -6.1359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3311   -6.6208    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    8.9100   -6.4715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2426   -5.9866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 13 22  4  0  0  0  0
 16 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3274

>  <JC_XSMILES>
CCN(CC)CCNC1=NC=NC2=C1NC3=CC=C(Br)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.288

>  <W2 Pf proliferation inhibition EC50 uM>
0.318

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.5

>  <Powder data?>
Yes

>  <IFI value>
0.056603774

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3275
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  5 14  4  0  0  0  0
  9 14  4  0  0  0  0
  7 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3275

>  <JC_XSMILES>
NCCNC1=CC(=NC2=CC=CC=C12)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.318

>  <W2 Pf proliferation inhibition EC50 uM>
0.375

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.02

>  <Powder data?>
Yes

>  <IFI value>
0.044247788

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3276
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -1.6296   -4.0736    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.8227   -3.9021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5677   -3.1175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2392   -2.9459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7913   -3.5590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5983   -3.3875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5363   -4.3437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2706   -4.5152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  7 20  1  0  0  0  0
 10 20  4  0  0  0  0
  5 21  4  0  0  0  0
 21 22  4  0  0  0  0
  2 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3276

>  <JC_XSMILES>
ClC1=CC=C(CN2CCN3C(=O)C4=CC=CC=C4N=C23)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.608

>  <W2 Pf proliferation inhibition EC50 uM>
1.626

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.075757576

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3279
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    4.2584    1.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9728    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9728    2.3568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6873    1.1193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4018    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1162    1.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1162    0.2943    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8307    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5452    1.1193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2989    1.4548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5538    2.2395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3608    2.4110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9128    1.7979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7198    1.9694    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   10.6579    1.0133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8509    0.8418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4384    0.1273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6933   -0.6573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1413   -1.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3962   -2.0551    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    8.3343   -1.0989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0794   -0.3143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6314    0.2988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  9 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3279

>  <JC_XSMILES>
CC(C)NCC(O)CN1C2=CC=C(Br)C=C2C3=CC(Br)=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2165

>  <W2 Pf proliferation inhibition EC50 uM>
0.0544

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.36

>  <Powder data?>
Yes

>  <IFI value>
0.031914894

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-328
  Mrv1591402191617072D          

 34 35  0  0  0  0            999 V2000
    2.1434   -0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -8.2500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -7.4250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -7.4250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -6.9020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -5.4730    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -1.7605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.1895    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164   -1.7605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -3.1895    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
  9 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 23 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 28 31  1  0  0  0  0
 21 32  4  0  0  0  0
  7 32  4  0  0  0  0
  5 33  4  0  0  0  0
 33 34  4  0  0  0  0
  2 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-328

>  <JC_XSMILES>
FC1=CC=C(NC2=NC(OC(C(F)(F)F)C(F)(F)F)=NC(OC(C(F)(F)F)C(F)(F)F)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.338

>  <W2 Pf proliferation inhibition EC50 uM>
1.567

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.015384615

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3282
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 13 12  1  4  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 14 23  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3282

>  <JC_XSMILES>
COC1=CC=C(C=C1)S(=O)(=O)ON=C2C=C(C(C)C)C(=O)C=C2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.834

>  <W2 Pf proliferation inhibition EC50 uM>
0.2963

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.34

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3283
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
  2 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
M  CHG  2  22   1  23  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3283

>  <JC_XSMILES>
CC1=NC2=CC=CC=C2C(=O)N1NC(=O)C3=CC=CC(=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1409

>  <W2 Pf proliferation inhibition EC50 uM>
1.613

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.010526316

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3284
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    8.5051   -2.1859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9531   -2.7990    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1461   -2.6275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5941   -3.2406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7871   -3.0690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5322   -2.2844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4703   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0842   -1.6713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8912   -1.8429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 17 22  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  4  0  0  0  0
  3 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3284

>  <JC_XSMILES>
COC1=CC=C(CCNC2=NC=NC3=C2NC4=CC=CC=C34)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2987

>  <W2 Pf proliferation inhibition EC50 uM>
0.401

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
24.88

>  <Powder data?>
Yes

>  <IFI value>
0.137254902

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3285
  Mrv1591402191617072D          

 43 48  0  0  0  0            999 V2000
    3.9844    1.6281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6989    1.2156    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6989    0.3906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4133   -0.0219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4133   -0.8469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6989   -1.2594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9844   -0.8469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9844   -0.0219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6989   -2.0844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3663   -2.5693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1114   -3.3540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2864   -3.3540    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0314   -2.5693    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2468   -2.3144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0753   -1.5074    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6337   -2.8664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8491   -2.6115    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2360   -3.1635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -3.9840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5686   -4.3196    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0165   -3.7065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8040   -3.7927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2889   -3.1253    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1094   -3.2115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4449   -3.9652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5943   -2.5441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4193   -2.5441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6742   -1.7594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0068   -1.2745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3393   -1.7594    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4290   -2.9920    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0935   -2.2383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7270   -2.1521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0626   -1.3984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5776   -0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2428   -0.8172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7278   -0.1498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5784   -1.5709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5963   -4.0214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4213   -4.0214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6762   -4.8060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0088   -5.2909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3414   -4.8060    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
 21 31  4  0  0  0  0
 18 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  1  0  0  0  0
 36 38  4  0  0  0  0
 32 38  4  0  0  0  0
 11 39  1  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 39 43  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3285

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2CC(=NN2C(=O)CSC3=NN=C(CNC(=O)C4=CC=CS4)N3C5=CC=CC(C)=C5)C6=CC=CS6

>  <PF proliferation inhibition 3D7 EC50 uM>
10.35

>  <W2 Pf proliferation inhibition EC50 uM>
1.611

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3287
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    6.4895    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0770    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2520    1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2520   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145   -1.0164    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -3.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -3.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -3.8743    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -3.8743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -4.5888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -3.1599    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
 13 18  4  0  0  0  0
 10 19  4  0  0  0  0
  6 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 21 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3287

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C(C=CC3=CC=CC=C23)=C1NC4=CC=C(NC(C)=O)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
6.9

>  <W2 Pf proliferation inhibition EC50 uM>
1.607

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3289
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  4  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3289

>  <JC_XSMILES>
CCN1C=CC=CC1=NC2=CC=CC=[N+]2CC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.503

>  <W2 Pf proliferation inhibition EC50 uM>
1.173

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>73.19

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3290
  Mrv1591402191617072D          

 43 49  0  0  0  0            999 V2000
    6.9246    1.5229    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6227    2.6499    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7977    1.2210    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9528    4.3924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7732    4.4787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1088    3.7250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1857    5.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7732    5.9076    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0107    5.1931    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4232    5.9076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2482    5.9076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6607    5.1931    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.2482    4.4787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4232    4.4787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4857    5.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8982    4.4787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7232    4.4787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1357    3.7642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7232    3.0497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8982    3.0497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4857    3.7642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8982    5.9076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4857    6.6221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8982    7.3365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7232    7.3365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1357    6.6221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7232    5.9076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  5 13  1  0  0  0  0
  9 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 22 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
  7 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 38 42  4  0  0  0  0
 42 43  4  0  0  0  0
 35 43  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3290

>  <JC_XSMILES>
FC(F)(F)C1CC(NC2=CC(=NN12)C(=O)N3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5)C6=CC=C7OCOC7=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
5.26

>  <W2 Pf proliferation inhibition EC50 uM>
1.602

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3292
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.1486    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   22.1486    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.8631    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.8631   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   23.5775   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   22.1486   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 16 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3292

>  <JC_XSMILES>
CCCCCC(=O)NCCCCCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2535

>  <W2 Pf proliferation inhibition EC50 uM>
0.2216

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>13.88

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3294
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
 13 22  4  0  0  0  0
  7 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
  1 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3294

>  <JC_XSMILES>
C(COC1=CC=C(NC2=CC=NC3=CC4=CC=CC=C4C=C23)C=C1)OC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1244

>  <W2 Pf proliferation inhibition EC50 uM>
0.0975

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.11

>  <Powder data?>
Yes

>  <IFI value>
0.061538462

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3298
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -0.2549    0.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8792   -0.6674    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -1.3349    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7224   -1.3819    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7224    0.0470    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5474    0.0470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9599    0.7615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7849    0.7615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1974    1.4760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7849    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1974    2.9049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9599    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5474    1.4760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
  5 10  4  0  0  0  0
  3 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3298

>  <JC_XSMILES>
CN1C(=CC2=C1C=C(Cl)S2)C(=O)NCC3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
3.128

>  <W2 Pf proliferation inhibition EC50 uM>
1.592

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3303
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    1.4229   -2.4457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4758    0.3498    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2828    0.5213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5377    1.3059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3447    1.4774    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6802    2.2311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5007    2.1449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6722    1.3379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9578    0.9254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 16  1  0  0  0  0
  8 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  7 20  4  0  0  0  0
 20 21  4  0  0  0  0
  5 21  4  0  0  0  0
 21 22  4  0  0  0  0
  2 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3303

>  <JC_XSMILES>
CC1=CC=C2NC3=C(NCCN4CCCC4)N=CN=C3C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.514

>  <W2 Pf proliferation inhibition EC50 uM>
0.737

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
46.49

>  <Powder data?>
Yes

>  <IFI value>
0.08

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3304
  Mrv1591402191617072D          

 53 58  0  0  1  0            999 V2000
    1.9206   -6.4816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -5.6566    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -5.2441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -5.6566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2228   -5.2441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2228   -4.4191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -4.0066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -3.1816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2228   -2.7691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2228   -1.9441    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -0.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -0.1923    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -0.3758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8843    0.2692    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7279   -1.1191    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.5529   -1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9654   -0.4047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5529    0.3098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9654    1.0243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7904    1.0243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2029    1.7387    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2029    0.3098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7904   -0.4047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -1.8624    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8843   -2.5075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5829   -3.2754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0973   -3.9204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9131   -3.7975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7959   -4.6884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7001   -2.3845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2145   -3.0295    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0015   -1.6165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8173   -1.4936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1187   -0.7256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9345   -0.6026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4489   -1.2476    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1475   -2.0156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3317   -2.1386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2647   -1.1247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5661   -0.3567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0517    0.2883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3531    1.0563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1689    1.1792    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6833    0.5342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3819   -0.2338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -2.0460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3821   -2.8503    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -4.4191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 18 16  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 18 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 28 33  1  0  0  0  0
 33 34  2  0  0  0  0
 33 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 36 41  1  0  0  0  0
 39 42  1  0  0  0  0
 42 43  1  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 43 48  4  0  0  0  0
 27 49  1  0  0  0  0
 49 50  2  0  0  0  0
 49 51  1  0  0  0  0
 14 51  4  0  0  0  0
 51 52  4  0  0  0  0
 11 52  4  0  0  0  0
  7 53  4  0  0  0  0
  3 53  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3304

>  <JC_XSMILES>
COC1=CC=CC(CCOC2=CC=C3NC(=O)[C@H](CC4=CC=C(O)C=C4)N(C(CC(C)C)C(=O)NC5CCN(CC5)CC6=CC=CC=C6)C(=O)C3=C2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.502

>  <W2 Pf proliferation inhibition EC50 uM>
0.1585

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.047169811

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3305
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -8.0087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 22 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3305

>  <JC_XSMILES>
CCC(C)C(=O)N1CCC(CC1)C(=O)NC2=CC=C(C=C2)C3=NC4=CC=CC=C4O3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.862

>  <W2 Pf proliferation inhibition EC50 uM>
1.585

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3307
  Mrv1591402191617072D          

 46 51  0  0  0  0            999 V2000
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  5 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 17 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 22 28  1  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
 18 36  1  0  0  0  0
 36 37  2  0  0  0  0
 36 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 41 46  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3307

>  <JC_XSMILES>
COC1=CC(=CC=C1OCC2=CC=CC=C2)C3C(=C(C)NC4=C3C(=O)CC(C4)C5=CC=C(Cl)C=C5)C(=O)OCCC6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
6.94

>  <W2 Pf proliferation inhibition EC50 uM>
1.582

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3308
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  CHG  1  10   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3308

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=CN3C=CC=CC3=[N+]2C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2136

>  <W2 Pf proliferation inhibition EC50 uM>
0.817

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
51.67

>  <Powder data?>
Yes

>  <IFI value>
0.065217391

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3310
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309    1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 11 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   7
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3310

>  <JC_XSMILES>
OC1=C(SC2=NNC=N2)C=C(NS(=O)(=O)C3=CC=C(F)C=C3)C4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
1.597

>  <W2 Pf proliferation inhibition EC50 uM>
0.323

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.46

>  <Powder data?>
Yes

>  <IFI value>
0.230769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3315
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8971    2.3981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4491    1.7850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0366    1.0705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2296    1.2420    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    0.7526    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.0320    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -0.0320    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    0.7526    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 11 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
  7 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  22
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3315

>  <JC_XSMILES>
CC(C)C1=CC=C(NC(=O)C(CC2=CC=CS2)C3=NN=NN3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
11.26

>  <W2 Pf proliferation inhibition EC50 uM>
1.572

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047169811

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3316
  Mrv1591402191617072D          

 33 38  0  0  0  0            999 V2000
   -3.1034   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -2.8413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -2.8413    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4931   -0.4229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4931   -0.9729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7846   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -4.2703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5784   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659   -2.8413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409   -2.8413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 16 22  1  0  0  0  0
 20 22  1  0  0  0  0
 19 23  1  0  0  0  0
 15 23  1  0  0  0  0
 23 24  1  0  0  0  0
 12 24  1  0  0  0  0
 24 25  2  0  0  0  0
  2 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3316

>  <JC_XSMILES>
CC(OC(=O)C1=CC=CC=C1N2C(=O)C3C4C=CC(C5CC45)C3C2=O)C(=O)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.961

>  <W2 Pf proliferation inhibition EC50 uM>
1.571

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3319
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
  5 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3319

>  <JC_XSMILES>
CC1=CC=C2C(C)=NC(NC(N)=N)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.406

>  <W2 Pf proliferation inhibition EC50 uM>
0.756

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.16

>  <Powder data?>
Yes

>  <IFI value>
0.029411765

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3320
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    5.0645    1.4672    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3813   -0.2736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8293   -0.8867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0223   -0.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435    1.9817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 12 14  4  0  0  0  0
  8 14  4  0  0  0  0
 11 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  4  0  0  0  0
 10 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3320

>  <JC_XSMILES>
FC1=CC=CC=C1C2=NC3=C(C(=O)O2)C4=C(CCCC4)S3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.569

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.010416667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3321
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5700    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
  5 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 14 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 13 29  1  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3321

>  <JC_XSMILES>
CC(=O)N(C1=CC=C(Cl)C(Cl)=C1)C2=C(N3CCOCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2195

>  <W2 Pf proliferation inhibition EC50 uM>
0.1914

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.22

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3322
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6658    2.8193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    3.4867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3963    3.2318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2712    3.7167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3963    2.4068    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 10 15  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 21 27  1  0  0  0  0
 19 28  4  0  0  0  0
 28 29  4  0  0  0  0
 16 29  4  0  0  0  0
 29 30  4  0  0  0  0
  5 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3322

>  <JC_XSMILES>
COC(=O)C1=C(NC(=O)C2=CC=C(C)S2)C3=CC=C(CN4CCCC(C)C4)N=C3S1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.813

>  <W2 Pf proliferation inhibition EC50 uM>
1.564

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.008695652

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3324
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  2  0  0  0  0
  5  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
  4 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
  3 24  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3324

>  <JC_XSMILES>
CNC1=C(N(C(C)=O)C2=CC=C(Br)C=C2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1619

>  <W2 Pf proliferation inhibition EC50 uM>
0.1561

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3325
  Mrv1591402191617072D          

 34 36  0  0  1  0            999 V2000
    3.3048   -1.1701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8425   -0.4868    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.0196   -0.5455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5573    0.1378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7344    0.0791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2721    0.7624    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.1902    1.4457    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6327    1.5044    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4556    1.5631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8162    2.3052    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.6391    2.3639    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9997    3.1059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5374    3.7892    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8226    3.1646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2849    2.4813    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.1078    2.5400    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9243    1.7393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2749    1.2305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2092    2.1508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3866    1.0560    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2095    1.1147    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0260    0.3140    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.4883   -0.3693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2031    0.2553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7408    0.9386    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3539    2.9885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5310    2.9297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7145    3.7305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2522    4.4138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4276    4.4414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1991    5.2341    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8824    5.6964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9100    6.5209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5332    5.1894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  6  5  1  0  0  0  0
  6  7  1  1  0  0  0
  8  7  1  1  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 15 14  1  0  0  0  0
 15 16  1  6  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 22 20  1  0  0  0  0
 22 23  1  6  0  0  0
 22 24  1  0  0  0  0
  2 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 26  1  1  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3325

>  <JC_XSMILES>
C[C@H]1CCC[C@H]2O[C@H]2C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)C1O)\C(C)=C\C3=CSC(C)=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.029

>  <W2 Pf proliferation inhibition EC50 uM>
0.1555

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.068965517

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3326
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
   -6.1617   -1.1038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3367   -1.1038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9242   -0.3893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0992   -0.3893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6867   -1.1038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8617   -1.1038    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4492   -1.8183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8617   -2.5327    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6242   -1.8183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1393   -2.4857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3942   -3.2703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3547   -2.2308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3598   -2.6433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0743   -2.2308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0743   -1.4058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7193   -0.8914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5236   -1.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8816   -1.8183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5236   -2.5616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7193   -2.7452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3598   -0.9933    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3547   -1.4058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1393   -1.1508    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.3598   -3.4683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0273   -3.9532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7723   -4.7378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0527   -4.7378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3076   -3.9532    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0992   -1.8183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9242   -1.8183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 14 20  1  0  0  0  0
 15 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 22 23  4  0  0  0  0
  9 23  4  0  0  0  0
 13 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 24 28  4  0  0  0  0
  5 29  4  0  0  0  0
 29 30  4  0  0  0  0
  2 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3326

>  <JC_XSMILES>
CC1=CC=C(NC(=O)C2=C(N)C3=C(C4=C(CCCCC4)N=C3S2)C5=CC=CS5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
5.57

>  <W2 Pf proliferation inhibition EC50 uM>
1.555

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024096386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3327
  Mrv1591402191617072D          

 43 48  0  0  0  0            999 V2000
   -1.8177   -3.9249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2129   -3.3637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3965   -2.5594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7917   -1.9983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0034   -2.2414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1802   -3.0457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4246   -3.6069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6014   -1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4178   -0.8760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0226   -0.3148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8390    0.4895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8109   -0.5580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3253    0.0870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1503    0.0870    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5083    0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0435    1.5120    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3309    0.8920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3926    0.0693    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2693    1.7147    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1536    0.9536    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.6647   -0.5580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4530   -0.3148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0578   -0.8760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8742   -1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0859   -1.9235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4811   -1.3623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7378   -1.7203    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9945   -1.3623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3897   -1.9235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9673    0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1447    0.8920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7867    1.6353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2514    2.3169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8935    3.0602    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3582    3.7419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1809    3.6802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6457    4.3618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4683    4.3002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8263    3.5569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3616    2.8752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5389    2.9369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0741    2.2553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4321    1.5120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 14 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 12 28  1  0  0  0  0
 28 29  1  0  0  0  0
  8 29  1  0  0  0  0
 13 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 36 41  4  0  0  0  0
 33 42  4  0  0  0  0
 42 43  4  0  0  0  0
 30 43  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3327

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2CC(O)=C3C(N(C(=O)C(F)(F)F)C4=CC=CC=C4N=C3C2)C5=CC=C(OCC6=CC=CC=C6)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.658

>  <W2 Pf proliferation inhibition EC50 uM>
1.555

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3328
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 21 31  4  0  0  0  0
 25 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3328

>  <JC_XSMILES>
CCCCCCC1=CC=C(C=C1)C(=O)NCCCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2406

>  <W2 Pf proliferation inhibition EC50 uM>
0.1686

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.85

>  <Powder data?>
No

>  <IFI value>
0.021276596

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-333
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -0.8212    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    2.2902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.2902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    2.2902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -0.1848    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.0527    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.1848    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5620   -1.9072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3071   -2.6919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4821   -2.6919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2272   -1.9072    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.0527    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 15 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 30 34  1  0  0  0  0
 27 35  4  0  0  0  0
 12 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-333

>  <JC_XSMILES>
CC1CCCCN1CCCNC2=NC=C(C(=O)NCCC3=CC=CC=C3)C(NCC4CCCO4)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.914

>  <W2 Pf proliferation inhibition EC50 uM>
>1.557

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.038095238

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3330
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6116   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1636    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7511    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9441    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  6 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 10 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 15 23  1  0  0  0  0
 11 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 27 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3330

>  <JC_XSMILES>
COC1=CC=C(C=C1Br)C2C(=C(C)NC3=C2C(=O)CC(C)(C)C3)C(=O)OC4CCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
7

>  <W2 Pf proliferation inhibition EC50 uM>
1.552

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3331
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    5.8461    2.4305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0578    2.1873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4530    2.7485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6647    2.5053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4811    1.7010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7378    1.3430    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9945    1.7010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8109    2.5053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3253    3.1503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1503    3.1503    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9673    3.8936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1447    3.9553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7867    4.6986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2514    5.3802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8935    6.1235    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.0741    5.3185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5389    6.0002    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.4321    4.5752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0226    2.7485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8390    3.5528    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4178    2.1873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6014    1.3830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2226    1.3419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4988    0.5644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3897    1.1398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0859    1.1398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8742    1.3830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4790    0.8219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  4 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 11 18  4  0  0  0  0
  8 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  7 25  1  0  0  0  0
  5 26  4  0  0  0  0
 26 27  4  0  0  0  0
  2 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3331

>  <JC_XSMILES>
CC1=CC2=C(NC3=C(C(N2)C4=CC=C(Cl)C(F)=C4)C(=O)CC(C)(C)C3)C=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.074

>  <W2 Pf proliferation inhibition EC50 uM>
1

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
64.52

>  <Powder data?>
Yes

>  <IFI value>
0.012048193

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3332
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
   -0.5463   -4.3342    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.2608   -3.9217    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.9753   -4.3342    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2608   -3.0967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9753   -2.6842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9753   -1.8592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2608   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5463   -1.8592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5463   -2.6842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1681   -3.0967    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8826   -2.6842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5971   -3.0967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3116   -2.6842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0260   -3.0967    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7077   -2.6319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4960   -2.8751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7974   -3.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3849   -4.3575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5691   -4.4805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9644   -3.9193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6897   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6897   -0.6217    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4042   -1.8592    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1187   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8331   -1.8592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5476   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5476   -0.6217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8331   -0.2092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1187   -0.6217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2621   -0.2092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9766    0.2033    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8496    0.5053    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6746   -0.9236    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 14 20  1  0  0  0  0
  6 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 30 33  1  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3332

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(=CC=C1NCCCN2CCCCCC2)C(=O)NC3=CC=C(C=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1196

>  <W2 Pf proliferation inhibition EC50 uM>
0.328

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.18

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3333
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8871   -5.0906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2227   -4.3369    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3721   -5.7580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1971   -5.7580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4520   -6.5426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7846   -7.0275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1171   -6.5426    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
  2 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 24 28  4  0  0  0  0
 20 29  4  0  0  0  0
 29 30  4  0  0  0  0
 17 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3333

>  <JC_XSMILES>
CC(OC1=CC=C(Cl)C=C1Cl)C2=NC(=NO2)C3=CC=C(NC(=O)C4=CC=CO4)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3134

>  <W2 Pf proliferation inhibition EC50 uM>
0.551

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
35.59

>  <Powder data?>
Yes

>  <IFI value>
0.036363636

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3338
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   16.4328   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 13 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3338

>  <JC_XSMILES>
CCCCC(=O)N(C)CCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.124

>  <W2 Pf proliferation inhibition EC50 uM>
0.1543

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3342
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.2085    0.3661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9988    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2085   -0.1075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2050    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4906    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4906   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2050   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2050   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9195   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9195    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6340   -0.6957    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3484   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0629   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7774   -0.2832    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.3905    0.2688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1050   -0.1437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9334   -0.9507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1129   -1.0369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2925    0.3842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6280    1.1379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1431    1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4787    2.5590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2991    2.6452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7841    1.9778    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4485    1.2241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  4 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  CHG  1  14   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3342

>  <JC_XSMILES>
CC1(C)C2CCC1(C)C(C2)OCC[N+]3(CCCC3)CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1607

>  <W2 Pf proliferation inhibition EC50 uM>
0.1947

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.67

>  <Powder data?>
Yes

>  <IFI value>
0.096153846

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3347
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
  9 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 13 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 27 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3347

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=NC3=CC(=CC=C3CN2C(C)C)C(=O)NCCN4CCOCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
5.27

>  <W2 Pf proliferation inhibition EC50 uM>
1.531

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012195122

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3350
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    3.6018   -3.0331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  1  0  0  0  0
 13 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
  7 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3350

>  <JC_XSMILES>
CC1=CC(C)=CC(NC2=C(C(=O)C3=CC=CC=C23)C4=CC=CC=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.828

>  <W2 Pf proliferation inhibition EC50 uM>
1.529

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3353
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8128   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4628   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.3646    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0300    4.1626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8370    3.9911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919    3.2065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  6 14  4  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
  9 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
  2 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3353

>  <JC_XSMILES>
CC(NC(=O)C1=C2N=C(C=C(N2N=C1)C(F)(F)F)C3=CC=C(Br)C=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>10.78

>  <W2 Pf proliferation inhibition EC50 uM>
1.522

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.032258065

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3354
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
    3.3682   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5432   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1307   -4.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3057   -4.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7537   -3.7894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0862   -4.9455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5269   -5.4975    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3115   -5.2426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0565   -4.4580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5664   -6.0272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0961   -4.9876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7092   -5.5397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3223   -6.0917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2612   -4.9266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1572   -6.1528    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8932   -5.1170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3057   -5.8315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1307   -5.8315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 37 38  4  0  0  0  0
 29 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3354

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4=CC=C5C=CC=CC5=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.729

>  <W2 Pf proliferation inhibition EC50 uM>
0.1521

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.052631579

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3358
  Mrv1591402191617072D          

 25 29  0  0  0  0            999 V2000
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464    0.7035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0320    1.1160    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0320    1.9410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3175    2.3535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3175    3.1785    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0320    3.5910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0320    4.4160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464    4.8285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4609    4.4160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4609    3.5910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464    3.1785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464    2.3535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  6  5  1  4  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
  5 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
 24 25  1  0  0  0  0
  1 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3358

>  <JC_XSMILES>
C1CNC2=C(C=NC3=CN=C4C=CC=CC4=C3)C5=CC=CC=C5N2C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.663

>  <W2 Pf proliferation inhibition EC50 uM>
1.513

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-336
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
    5.7158    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.1612   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.9862    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   11.4315   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   10.7171   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 19 24  4  0  0  0  0
 20 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
M  CHG  2  25   1  26  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-336

>  <JC_XSMILES>
OCCN(CCO)CCCNS(=O)(=O)C1=CC=CC2=C(C=CC=C12)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.177

>  <W2 Pf proliferation inhibition EC50 uM>
>1.554

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3363
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -0.1251   -4.0496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5893   -4.4621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5893   -5.2871    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3038   -4.0496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0183   -4.4621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7327   -4.0496    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4472   -4.4621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4472   -5.2871    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1617   -4.0496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8762   -4.4621    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5578   -3.9974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4348   -3.1816    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3462   -4.2405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8605   -3.5955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6763   -3.7185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9777   -4.4865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4633   -5.1315    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6476   -5.0085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2351   -5.7230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4193   -5.8459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2357   -6.6503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4474   -6.8934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8426   -6.3323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0262   -5.5280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8145   -5.2848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 10 25  1  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3363

>  <JC_XSMILES>
CC(C)CCNC(=O)CN1C(=O)C2=CC=CN=C2OC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
4.05

>  <W2 Pf proliferation inhibition EC50 uM>
1.505

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3364
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 14 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3364

>  <JC_XSMILES>
CCCCOC1=CC=C(C=C1)C(O)C(CN2CCCCC2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.835

>  <W2 Pf proliferation inhibition EC50 uM>
0.591

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
39.28

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3365
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -1.8659    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.6411   -2.7604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9606    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5126    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2577    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
  8 16  1  0  0  0  0
  4 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  4  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  CHG  2  13   1  14  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3365

>  <JC_XSMILES>
CC(=O)C1C(=O)C2=C(C=CC=C2[N+]([O-])=O)C1=NC3=CC=CC=C3C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.643

>  <W2 Pf proliferation inhibition EC50 uM>
0.777

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
51.73

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3366
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  1  0  0  0  0
 11 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
 32 33  1  0  0  0  0
  5 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
  2 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3366

>  <JC_XSMILES>
CC1=CC=C(NC(=O)C2=CC(=CN(C2=O)C3=CC=C(C)C=C3C)C(=O)C4=CC(Cl)=CC=C4O)C(C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.934

>  <W2 Pf proliferation inhibition EC50 uM>
0.885

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
58.98

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3367
  Mrv1591402191617072D          

 28 29  0  0  0  0            999 V2000
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.3033   -4.8395    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -3.4105    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 21 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3367

>  <JC_XSMILES>
CC(C)OC(=O)C1=CC=CN=C1SCC(=O)NC2=CC=C(C=C2Cl)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
5.54

>  <W2 Pf proliferation inhibition EC50 uM>
1.499

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3368
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    1.4289   -3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3368

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC=C1NC(=O)N2CCC(CC2)N3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.51

>  <W2 Pf proliferation inhibition EC50 uM>
1.498

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3369
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0224   -2.2231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8155   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4089   -2.5688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2093   -3.3693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4163   -3.5967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8228   -3.0236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0417   -2.3784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4788   -3.0781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0915   -3.8065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2670   -3.8353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1702   -3.1357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2172   -2.4072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
  1 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 10 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  2 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3369

>  <JC_XSMILES>
N1C(=NC2=CC=CC=C2C1(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.754

>  <W2 Pf proliferation inhibition EC50 uM>
0.59

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
39.42

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3371
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
  6 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  5 24  4  0  0  0  0
 24 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3371

>  <JC_XSMILES>
ClC1=CC=C2C(NCCCCNC(=O)C3CCCCC3)=CC=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.311

>  <W2 Pf proliferation inhibition EC50 uM>
0.1983

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>13.28

>  <Powder data?>
No

>  <IFI value>
0.046728972

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3375
  Mrv1591402191617072D          

 48 55  0  0  0  0            999 V2000
   -3.4088    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6944    2.1918    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    2.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654   -1.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6944   -1.9332    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4088   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771    0.7967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320    1.5814    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8620    0.1293    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771   -0.5381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320   -1.3228    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6870    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0995    0.8438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9245    0.8438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3370    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1620    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9245   -0.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0995   -0.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    2.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    3.0168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    3.4293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    3.0168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    2.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6717    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1533    0.1293    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -1.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -2.7582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -3.1707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635   -2.7582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635   -1.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  4  0  0  0  0
 11 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 25 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
 21 34  1  0  0  0  0
  9 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 35 40  4  0  0  0  0
 34 41  1  0  0  0  0
 19 41  1  0  0  0  0
 41 42  2  0  0  0  0
 19 43  1  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 43 48  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3375

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C(C3=CC=C(OC)C=C3)C4(C5C(C(=O)N(C5=O)C6=CC=C(C)C=C6)C2(C7=CC=CC=C7)C4=O)C8=CC=CC=C8

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.485

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3376
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -2.1678   -3.2281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -3.6406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7389   -3.2281    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0244   -3.6406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6900   -3.2281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4045   -3.6406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4045   -4.4656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190   -4.8781    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8334   -4.4656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8334   -3.6406    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5479   -4.8781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5479   -5.7031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2624   -4.4656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9769   -4.8781    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.6913   -4.4656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7776   -3.6451    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5845   -3.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9970   -2.7591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8220   -2.7591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2345   -3.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0595   -3.4736    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.4720   -2.7591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0595   -2.0446    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.2970   -2.7591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7095   -2.0446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8220   -4.1880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9970   -4.1880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4450   -4.8011    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6900   -4.8781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0244   -4.4656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 26  4  0  0  0  0
 26 27  4  0  0  0  0
 17 27  4  0  0  0  0
 27 28  4  0  0  0  0
 15 28  4  0  0  0  0
  7 29  4  0  0  0  0
 29 30  4  0  0  0  0
  4 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3376

>  <JC_XSMILES>
CCOC1=CC=C(NC(=O)C(C)CSC2=NC3=CC=C(NC(=O)CC)C=C3S2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.483

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011764706

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3378
  Mrv1591402191617072D          

 35 37  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 18 24  4  0  0  0  0
  6 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3378

>  <JC_XSMILES>
CCCC(=O)N(CCN1CCN(CC1)C(=O)NC2=CC=CC(C)=C2)C\C=C\C3=CC=CC=C3OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.1483

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028037383

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3379
  Mrv1591402191617072D          

 23 27  0  0  0  0            999 V2000
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1369   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6218   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1369   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4944   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2201   -3.9979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9345   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9345   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2201   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4944   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 10 22  4  0  0  0  0
  3 22  4  0  0  0  0
 22 23  1  0  0  0  0
  1 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3379

>  <JC_XSMILES>
C1CC2=NC3=NN=CN3C(NC4=CC=C5OCCOC5=C4)=C2C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.953

>  <W2 Pf proliferation inhibition EC50 uM>
1.482

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-338
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  3 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  2  0  0  0  0
 31 33  4  0  0  0  0
 23 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  1  0  0  0  0
 37 39  4  0  0  0  0
 39 40  4  0  0  0  0
 34 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-338

>  <JC_XSMILES>
CCC(N(CCC1=CC=CC=C1)C(=O)CCC2=CC=CC=C2)C3=NC4=CC=CC=C4C(=O)N3C5=CC=C(F)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.524

>  <W2 Pf proliferation inhibition EC50 uM>
1.545

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.031578947

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3380
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
  7 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
  2 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 29 32  1  0  0  0  0
 32 33  2  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 32 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3380

>  <JC_XSMILES>
O=C(NC1=CC=C(NC(=O)C2=CC=C(C=C2)C3=NCCCN3)C=C1)NC4=CC=C(C=C4)C5=NCCCN5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1154

>  <W2 Pf proliferation inhibition EC50 uM>
0.1482

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009090909

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3384
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 12  9  1  4  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3384

>  <JC_XSMILES>
CCN(CC)C1=CC=C(C=C1)N=CC2=CC=CC=C2[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.571

>  <W2 Pf proliferation inhibition EC50 uM>
0.41

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
27.71

>  <Powder data?>
Yes

>  <IFI value>
0.103174603

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3385
  Mrv1591402191617072D          

 34 35  0  0  0  0            999 V2000
    4.6776    0.4189    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8758   -0.3820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2813   -0.9540    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4887   -0.7252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8942   -1.2973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1016   -1.0684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9034   -0.2676    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1108   -0.0388    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9126    0.7621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1200    0.9909    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5071    1.3341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3089    2.1350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9034    2.7070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7053    3.5078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9126    3.7367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3089    5.1095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1108    5.9104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0782    4.7663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2763    5.5672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6961    2.4782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8942    1.6773    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.2905    3.0502    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0832    2.8214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6776    3.3934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4703    3.1646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0648    3.7367    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8574    3.5078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4519    4.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8666    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4611    5.1095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2997    1.1053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4979    0.3044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2905    0.0756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 13 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 11 32  4  0  0  0  0
 32 33  4  0  0  0  0
  7 33  4  0  0  0  0
 33 34  4  0  0  0  0
  4 34  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3385

>  <JC_XSMILES>
CCOC1=CC=C2NC(=O)C(CN(CCN(CC)CC)C(=S)NCCCN(CC)CC)=CC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
5.56

>  <W2 Pf proliferation inhibition EC50 uM>
1.476

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046296296

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3388
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
   -4.9631    2.3029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1381    2.3029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7256    3.0173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9006    3.0173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4881    2.3029    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9006    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7256    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6631    2.3029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2506    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6631    0.8739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4881    0.8739    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2506    0.1595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4256    0.1595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0131    0.8739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4256    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0131    2.3029    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8119    2.3029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2244    3.0173    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2244    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8119    0.8739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0494    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5343    2.2558    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3189    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0334    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0334    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3189    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5343    0.9210    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  2  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
 21 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3388

>  <JC_XSMILES>
CC1CCN(CC1)CC2=C(O)C=CC3=C2OC(=O)C(=C3)C4=NC5=CC=CC=C5S4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.472

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.06993007

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-339
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 16 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 14 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  3  0  0  0  0
  8 30  4  0  0  0  0
 30 31  4  0  0  0  0
  5 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-339

>  <JC_XSMILES>
COC(=O)C1=CC=C(NC(=O)CSC2=NC3=CC4=C(OCCO4)C=C3C=C2C#N)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.613

>  <W2 Pf proliferation inhibition EC50 uM>
1.544

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3392
  Mrv1591402191617072D          

 41 44  0  0  0  0            999 V2000
   -6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -3.8230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -5.2520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 10 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 30 38  4  0  0  0  0
 38 39  4  0  0  0  0
 27 39  4  0  0  0  0
  6 40  4  0  0  0  0
 40 41  4  0  0  0  0
  3 41  4  0  0  0  0
M  CHG  2  24   1  25  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3392

>  <JC_XSMILES>
COC1=CC=C(NC(=O)N(CCCNS(=O)(=O)C2=CC=C(C=C2)[N+]([O-])=O)C3=CC=C(OC4=CC=CC=C4)C=C3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.733

>  <W2 Pf proliferation inhibition EC50 uM>
0.1141

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>7.77

>  <Powder data?>
No

>  <IFI value>
0.009009009

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3394
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    3.4942    4.7212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4850    5.7508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2776    5.9797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4758    6.7805    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8721    5.4076    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6647    5.6364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2592    5.0644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0518    5.2932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6463    4.7212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4389    4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0334    4.3780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8261    4.6068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4205    4.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2224    3.2339    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4297    3.0051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2316    2.2042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4389    1.9754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2408    1.1746    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.8445    2.5475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0426    3.3483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8353    3.5771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8905    6.3229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0979    6.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5034    6.6661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7016    7.4670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4942    7.6958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0887    7.1237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 16 22  4  0  0  0  0
  3 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3394

>  <JC_XSMILES>
CCC(C(=O)NCCCCNC1=CC=NC2=CC(Cl)=CC=C12)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2877

>  <W2 Pf proliferation inhibition EC50 uM>
0.1685

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.5

>  <Powder data?>
No

>  <IFI value>
0.066037736

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3395
  Mrv1591402191617072D          

 29 30  0  0  0  0            999 V2000
    0.0000   -3.0789    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -0.9355    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8875   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7125   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1250   -3.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7125   -3.7934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8875   -3.7934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750   -3.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -3.0789    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.1250   -4.5079    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.7125   -5.2224    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.9500   -4.5079    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    1.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    0.4934    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.2211    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.6500    1.2079    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375    1.9224    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.0625    1.9224    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.8250    2.6368    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
  4 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 21 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  2  0  0  0  0
M  CHG  6  15   1  16  -1  24   1  25  -1  27   1  28  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3395

>  <JC_XSMILES>
OCCN(CCNC1=CC=C(C=C1Cl)[N+]([O-])=O)C2=CC=C(C=C2[N+]([O-])=O)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.668

>  <W2 Pf proliferation inhibition EC50 uM>
0.529

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
36.12

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3399
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -5.3033    8.9645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5888    9.3770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8743    8.9645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599    9.3770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4454    8.9645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4454    8.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309    7.7270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164    8.1395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020    7.7270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    8.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    7.7270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    6.9020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    6.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020    6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414    6.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    6.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    5.6645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    5.2520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    4.4270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849    4.4270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414    5.6645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599    7.7270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8743    8.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 25  1  0  0  0  0
 19 26  4  0  0  0  0
 15 26  4  0  0  0  0
  6 27  4  0  0  0  0
 27 28  4  0  0  0  0
  3 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3399

>  <JC_XSMILES>
COC1=CC=C(CNC2CCN(CC2)C3=CC=CC(NC(=O)C4CC4)=C3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.954

>  <W2 Pf proliferation inhibition EC50 uM>
0.948

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
65.08

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3401
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  6 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  5 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3401

>  <JC_XSMILES>
CC1=C(C)C2=C(NC3=CC=NC=C3)N=CN=C2S1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>1.453

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027027027

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3402
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.5433   -1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5983   -0.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3433    0.3012    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5983   -3.3875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1503   -4.0006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8953   -4.7852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4474   -5.3983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1924   -6.1829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3855   -6.3545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1305   -7.1391    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.8334   -5.7414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0884   -4.9567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5363   -4.3437    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  3  0  0  0  0
  3  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  6 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3402

>  <JC_XSMILES>
NC1=C(C#N)C2=NC3=CC=CC=C3N=C2N1CCC4=CC=C(Cl)C=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.828

>  <W2 Pf proliferation inhibition EC50 uM>
0.485

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
33.39

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3405
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    4.3808    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    5.6479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    4.8229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  4  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 12 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
 10 24  4  0  0  0  0
 24 25  1  0  0  0  0
  6 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3405

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N=c2sc(=CC3=CC(Cl)=CC=C3O)c(=O)n2C1C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
5.69

>  <W2 Pf proliferation inhibition EC50 uM>
1.445

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3406
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -3.3904    0.1995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7230   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9384   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9384   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7230   -1.1104    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  4  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 10 23  4  0  0  0  0
  7 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3406

>  <JC_XSMILES>
CC1=NC(=CS1)C2=NC3=C(CN(CC3)C(=O)C4=CC=NC=C4)S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1632

>  <W2 Pf proliferation inhibition EC50 uM>
0.1442

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-341
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  5 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-341

>  <JC_XSMILES>
CC1=CC=C(NC(=O)CN2CCN(CC2)C3=CC=CC=N3)C=C1F

>  <PF proliferation inhibition 3D7 EC50 uM>
2.083

>  <W2 Pf proliferation inhibition EC50 uM>
>1.542

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3411
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
M  CHG  2  19   1  20  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3411

>  <JC_XSMILES>
OC1=CC=C(Br)C=C1C(=O)NC2=CC=C(C=C2Cl)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.798

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
55.57

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3414
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    0.7145    0.4125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -0.4125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -0.4125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3414

>  <JC_XSMILES>
BrC(Br)(Br)C1=NC=C(C=N1)C2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0433

>  <W2 Pf proliferation inhibition EC50 uM>
0.1428

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3416
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
  9 15  4  0  0  0  0
  8 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 16 25  4  0  0  0  0
 25 26  1  0  0  0  0
  6 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3416

>  <JC_XSMILES>
CC1=CC=CC(NC(C2=CC=CC(Cl)=C2)C3=CC=C4C=CC=NC4=C3O)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.917

>  <W2 Pf proliferation inhibition EC50 uM>
0.891

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>62.41

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3417
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559   -3.6020    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3417

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(=O)C2CC2C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2171

>  <W2 Pf proliferation inhibition EC50 uM>
1.425

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.037974684

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3418
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
  8 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  CHG  2  15   1  16  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3418

>  <JC_XSMILES>
CCCCC(=O)NC(C1=CC=CC(=C1)[N+]([O-])=O)C2=CC=C3C=CC=NC3=C2O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.376

>  <W2 Pf proliferation inhibition EC50 uM>
0.267

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.75

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3419
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.3194   -1.4811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4875   -1.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7425   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -0.4849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4211    0.9744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5074    0.1539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2610   -0.1817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3473   -1.0022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1009   -1.3377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7684   -0.8528    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6821   -0.0323    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9285    0.3032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  8 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
  5 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3419

>  <JC_XSMILES>
CC(C)CN1C(=O)N(CCCC2=CC=CN=C2)C(=O)C13CCN(CC3)C4CCOCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.422

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.063291139

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-342
  Mrv1591402191617072D          

 30 35  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0420    1.3770    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8625    1.4633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0340    2.2702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3196    2.6827    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2333    3.5032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4797    3.8388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8122    3.3539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0585    3.6894    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065    2.1307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8860    2.0445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7877    2.6058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1472    3.1257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0520    3.0365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0097    2.2126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6503    1.6926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3331    1.9965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3753    2.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7348    3.3405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4705    2.9098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7455    1.7818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  2  0  0  0  0
  3  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 17  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
  7 18  4  0  0  0  0
 11 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
 25 27  1  0  0  0  0
 19 27  1  0  0  0  0
 23 28  1  0  0  0  0
 19 28  1  0  0  0  0
  8 29  4  0  0  0  0
  2 29  4  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-342

>  <JC_XSMILES>
CN1C(=O)N(C)C2=C(N3C=C(N(CCCO)C3=N2)C45CC6CC(CC(C6)C4)C5)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.541

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3420
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
  9 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
 19 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  CHG  2  16   1  17  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3420

>  <JC_XSMILES>
CC1=CC=CN=C1NC(C2=CC=C(C=C2)[N+]([O-])=O)C3=CC=C4C=CC=NC4=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1404

>  <W2 Pf proliferation inhibition EC50 uM>
0.2138

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.04

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3422
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
  3 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3422

>  <JC_XSMILES>
COC1=CC(NC2=CN=CC(=N2)C3=CC=NC=C3)=CC(OC)=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.085

>  <W2 Pf proliferation inhibition EC50 uM>
1.419

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3426
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 15 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 19 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 21 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
  6 38  4  0  0  0  0
 38 39  4  0  0  0  0
  3 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3426

>  <JC_XSMILES>
COC1=CC=C(NC(=O)N2CCN(CC2C)C(=O)C3=NC(=NC(C)=C3C(=O)OC(C)C)C4=CC=CC=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.633

>  <W2 Pf proliferation inhibition EC50 uM>
0.1413

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3429
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    2.8734    0.4022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0665    0.2306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9104   -0.4368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3584   -1.0499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7389    0.3702    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4534    0.7827    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7934   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809   -0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0309   -1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8514   -2.0382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0229   -2.8452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3084   -3.2577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6954   -2.7056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2222   -4.0782    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8897   -4.5631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6433   -4.2275    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8034   -5.3836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4709   -5.8685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2555   -5.6135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7404   -6.2810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2555   -6.9484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4709   -6.6935    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9059   -3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0809   -3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3316   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0809   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9059   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  3  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
 11 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3429

>  <JC_XSMILES>
CC1=C(C(C)=NO1)S(=O)(=O)N(CC(O)CN2CCC(C2)NC(=O)CC3=CC=CS3)CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.175

>  <W2 Pf proliferation inhibition EC50 uM>
0.141

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009615385

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-343
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8671   -5.1657    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2890   -4.3257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7739   -4.9932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5944   -4.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9299   -4.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4450   -3.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6245   -3.5721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7504   -4.0670    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.0860   -3.3134    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.2353   -4.7345    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8810   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4941   -3.2570    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0525   -1.8980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8372   -1.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0087   -0.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7933   -0.5812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4064   -1.1332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2349   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4502   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 10 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  CHG  2  23   1  24  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-343

>  <JC_XSMILES>
CC1=CC=CC=C1NC2=C(C(N)=C(S2)C(=O)C3=CC=C(C=C3)[N+]([O-])=O)C(=O)NC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.203

>  <W2 Pf proliferation inhibition EC50 uM>
>1.541

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3430
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  8  7  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
  7 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 13 20  4  0  0  0  0
 20 21  4  0  0  0  0
  6 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3430

>  <JC_XSMILES>
CCOC(=O)C1=C(N=NN(C)C)C2=CC(OC)=CC=C2N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.447

>  <W2 Pf proliferation inhibition EC50 uM>
0.966

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
68.57

>  <Powder data?>
Yes

>  <IFI value>
0.062992126

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3431
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    4.3808    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  4  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 12 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
 10 24  4  0  0  0  0
 24 25  1  0  0  0  0
  6 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3431

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N=c2sc(=CC3=CC(Br)=CC=C3O)c(=O)n2C1C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
5.53

>  <W2 Pf proliferation inhibition EC50 uM>
1.405

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011764706

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3435
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    2.1434    0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184   -0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684   -0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3435

>  <JC_XSMILES>
FC(F)(F)C1CCCN(C1)C(=O)C2=CC=C(Cl)C=C2Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.663

>  <W2 Pf proliferation inhibition EC50 uM>
1.397

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3437
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6753   -3.7894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5037   -2.9825    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1232   -4.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5357   -5.1170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3427   -4.9455    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6972   -4.3163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0328   -3.5626    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1822   -4.9837    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
  9 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
  8 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 31 36  1  0  0  0  0
  7 37  4  0  0  0  0
  3 37  4  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3437

>  <JC_XSMILES>
COC1=CC=CC(C(N(C(=O)C2=C(N)C(=NS2)C(N)=O)C3=CC=C(C)C=C3)C(=O)NC4CCCCC4)=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
3.44

>  <W2 Pf proliferation inhibition EC50 uM>
1.395

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3439
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3390   -2.3346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6745   -1.5809    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5853   -1.9990    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0927   -2.6701    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  3 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3439

>  <JC_XSMILES>
CC1=C(SC(=N1)C2=CN=CC=C2C(F)(F)F)C(=O)NN

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.01

>  <W2 Pf proliferation inhibition EC50 uM>
1.391

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-344
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
    3.3629    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6484    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    3.9855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6484    2.7480    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.7556    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0710   -0.0514    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7279    1.5625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7064    0.9271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2585    0.3140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0654    0.4855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6785   -0.0665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3930    0.3460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2215    1.1530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4010    1.2392    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.7556    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9389   -0.0514    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5958    1.5625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5743    0.9271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8293    1.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6362    1.8832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9718    2.6369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7923    2.5507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9638    1.7437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2493    1.3312    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  6 18  1  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 24 28  4  0  0  0  0
  9 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  2  0  0  0  0
 29 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 34 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-344

>  <JC_XSMILES>
NC(=O)NN=C1C2=CC(=CC=C2C3=CC=C(C=C13)S(=O)(=O)NCC4=CC=CO4)S(=O)(=O)NCC5=CC=CO5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.184

>  <W2 Pf proliferation inhibition EC50 uM>
>1.541

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3440
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -1.3144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 23 29  4  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 33 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3440

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC(C)=C4)C(=O)OC5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2997

>  <W2 Pf proliferation inhibition EC50 uM>
0.2077

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.94

>  <Powder data?>
Yes

>  <IFI value>
0.107142857

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3444
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.0215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -3.8062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8538   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0333   -4.3874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6977   -3.6337    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5484   -5.0548    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2721   -4.9686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7571   -5.6360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5775   -5.5498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9131   -4.7961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4282   -4.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6077   -4.2149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1228   -3.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3622   -2.8800    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.0215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  3  0  0  0  0
 12 25  4  0  0  0  0
  9 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3444

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=NOC(CC(=O)NC3=CC=CC=C3C#N)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
6.08

>  <W2 Pf proliferation inhibition EC50 uM>
1.382

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3446
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    8.5003   -1.7771    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.7858   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.3646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7858   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
  5 24  4  0  0  0  0
 24 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3446

>  <JC_XSMILES>
ClC1=CC=C(NC(=O)N2CCN(CC2)C3=NN4C=NN=C4C=C3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.063

>  <W2 Pf proliferation inhibition EC50 uM>
1.376

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3448
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.9000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 15 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 24 31  4  0  0  0  0
  7 32  1  0  0  0  0
  2 32  1  0  0  0  0
M  CHG  2  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3448

>  <JC_XSMILES>
CC1CC(C)CN(CCCNC2=CC=C(C=C2[N+]([O-])=O)C(=O)NC3=CC=C(C)C(F)=C3)C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2186

>  <W2 Pf proliferation inhibition EC50 uM>
0.736

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>53.56

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-345
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    8.5737    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717    1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4467    0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  2 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 28 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 35 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-345

>  <JC_XSMILES>
O=C(CN(CCN1CCOCC1)S(=O)(=O)C2=CC=CC=N2)N3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.44

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>28.84

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3450
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
 10 11  4  0  0  0  0
  4 11  4  0  0  0  0
  3 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3450

>  <JC_XSMILES>
CCN(C1=CC=C(OC)C=C1)S(=O)(=O)C2=CC=C(C)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.372

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3452
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -1.9520   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3480   -0.5230    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7605   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3480   -1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5855   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9980   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8230   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2355   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0605   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8230   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9980   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    0.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.6204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9694    2.4050    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020    2.8899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3655    2.4050    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105    1.6204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230    0.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
  6 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 20 24  4  0  0  0  0
 24 25  4  0  0  0  0
 17 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3452

>  <JC_XSMILES>
COC(=O)CC(NC(=O)C1=CC=C(C)C=C1)C2=CC=C3OCOC3=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.684

>  <W2 Pf proliferation inhibition EC50 uM>
0.2059

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.03

>  <Powder data?>
No

>  <IFI value>
0.012195122

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3453
  Mrv1591402191617072D          

 31 33  0  0  1  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4647   -4.0640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0778   -4.6160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8624   -4.3611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4755   -4.9131    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2601   -4.6582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0339   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8186   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5924   -2.1951    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9793   -1.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -4.3257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4824   -3.5721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6318   -4.9932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4522   -4.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9372   -5.5744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6016   -6.3281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0865   -6.9955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7811   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2962   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  5  3  1  6  0  0  0
  5  6  1  0  0  0  0
  7  6  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 11 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
  7 22  1  1  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3453

>  <JC_XSMILES>
COC(=O)[C@@H]1C[C@H](CN1CC2=CC=C(OC)C(C)=C2OC)NC(=O)C3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.565

>  <W2 Pf proliferation inhibition EC50 uM>
0.1369

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008849558

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3454
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    7.2726   -3.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7206   -2.4814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9136   -2.6530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3615   -2.0399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6165   -1.2553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0645   -0.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    3.1605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4235   -1.0837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9755   -1.6968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  3  0  0  0  0
  5 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3454

>  <JC_XSMILES>
CC1=CC=C(COC2=CC=C3C(=C2)N4C=CC=CC4=C3C#N)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.094

>  <W2 Pf proliferation inhibition EC50 uM>
1.367

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.072916667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3458
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3458

>  <JC_XSMILES>
CC1=CC=CC(C)=C1OCC(=O)NC2=CC=CC=C2O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.742

>  <W2 Pf proliferation inhibition EC50 uM>
1.363

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3459
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    1.4874   -1.5953    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4874   -2.4203    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2019   -2.8328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2019   -3.6578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4874   -4.0703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4874   -4.8953    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7729   -5.3078    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.3604   -4.5933    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1854   -6.0223    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0584   -5.7203    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1201   -6.5430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4847   -7.1041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3005   -6.9812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7130   -6.2667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4115   -5.4987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6232   -5.2556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7729   -3.6578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7729   -2.8328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 10 16  1  0  0  0  0
  5 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3459

>  <JC_XSMILES>
FC1=CC=C(NS(=O)(=O)N2CCCCCC2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.359

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-346
  Mrv1591402191617072D          

 40 46  0  0  0  0            999 V2000
   -0.7845   -9.1725    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1200   -8.4188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9270   -8.2473    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0132   -7.4268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6807   -6.9419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5945   -6.1214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8408   -5.7858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1733   -6.2707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2596   -7.0912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7075   -7.7043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0994   -7.5328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3544   -6.7482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1977   -6.1351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7545   -4.9653    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9341   -5.0516    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5750   -4.8791    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6683   -4.1449    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9146   -3.8093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8284   -2.9888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0747   -2.6533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5927   -3.1382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3464   -2.8026    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4326   -1.9821    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2531   -2.0684    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6122   -1.8959    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5189   -1.1617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8514   -0.6767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9377    0.1437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6913    0.4793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9463    1.2639    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7713    1.2639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    1.9314    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0262    0.4793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3588   -0.0056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2725   -0.8261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1987   -1.1617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8661   -0.6767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7799    0.1437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5065   -3.9587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2472   -4.2942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  7 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  4  0  0  0  0
 26 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
 21 39  4  0  0  0  0
 39 40  4  0  0  0  0
 18 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-346

>  <JC_XSMILES>
O=C1NC2=CC=C(C3=C2C1=CC=C3)S(=O)(=O)NC4=CC=C(NS(=O)(=O)C5=CC=C6NC(=O)C7=C6C5=CC=C7)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.177

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.12

>  <Powder data?>
No

>  <IFI value>
0.020833333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3460
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  4  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  2 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3460

>  <JC_XSMILES>
CN(CC(=O)NN=CC1=CC=NC=C1)S(=O)(=O)C2=CC=C(NC(C)=O)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>5.76

>  <W2 Pf proliferation inhibition EC50 uM>
1.359

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3462
  Mrv1591402191617072D          

 45 52  0  0  1  0            999 V2000
    5.9875    2.6586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6519    1.9049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8314    1.8187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.4223    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4529    2.0221    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.8500   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3509   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1340    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3509    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1794    1.8869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7925    2.4389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5771    2.1840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7499    1.7895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4644    1.3770    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.5506    2.1975    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2490    1.6320    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    8.5846    2.3856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4050    2.2994    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5766    1.4924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8621    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6906    0.2730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3037   -0.2791    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9059    0.0180    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.7344   -0.7889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3475   -1.3410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1321   -1.0860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7452   -1.6381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5737   -2.4450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7891   -2.7000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1760   -2.1480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2929    0.5701    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4724    0.4838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0599   -0.2307    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  4  5  1  6  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  8  6  1  1  0  0  0
  8  9  1  0  0  0  0
 10  9  1  1  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  1  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 16 21  4  0  0  0  0
 11 22  1  6  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  8 24  1  0  0  0  0
  4 25  1  0  0  0  0
 26 25  1  0  0  0  0
 26 27  1  6  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 28 32  1  6  0  0  0
 32 33  1  0  0  0  0
 33 34  2  0  0  0  0
 35 33  1  0  0  0  0
 35 36  1  6  0  0  0
 36 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
 35 43  1  0  0  0  0
 26 43  1  0  0  0  0
 43 44  1  0  0  0  0
  4 44  1  0  0  0  0
 44 45  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3462

>  <JC_XSMILES>
CC(C)[C@@]5(NC(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C)C1)O[C@@]6(O)[C@@H]7CCCN7C(=O)[C@H](CC8=CC=CC=C8)N6C5=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.253

>  <W2 Pf proliferation inhibition EC50 uM>
0.449

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
33.14

>  <Powder data?>
Yes

>  <IFI value>
0.005714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3464
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -1.2288   -3.3957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -1.3144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -2.4705    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  2  0  0  0  0
  7 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  3  0  0  0  0
 13 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3464

>  <JC_XSMILES>
CC1=CC=C(O1)C2CC(=O)N3CN(CSC3=C2C#N)C4=CC=C(Br)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.352

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3465
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
 24 25  4  0  0  0  0
 12 25  1  0  0  0  0
 16 25  4  0  0  0  0
 13 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 31 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  2  0  0  0  0
  9 37  4  0  0  0  0
 37 38  4  0  0  0  0
  6 38  4  0  0  0  0
M  CHG  2  34   1  35  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3465

>  <JC_XSMILES>
CCOC(=O)C1=CC=C(OCC2N(CCC3=CC(OC)=C(OC)C=C23)C(=O)C4=CC=C(C=C4)[N+]([O-])=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.35

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3467
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -8.3312    1.6282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5107    1.7144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0258    1.0470    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2053    1.1332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8698    1.8869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0493    1.9731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5644    1.3057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7439    1.2195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8999    0.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7204    0.4658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 10 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  9 20  4  0  0  0  0
 20 21  4  0  0  0  0
  7 21  4  0  0  0  0
 21 22  4  0  0  0  0
  4 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3467

>  <JC_XSMILES>
CCOC1=CC=C2NC3=C(NCCN(C)C)N=CN=C3C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.773

>  <W2 Pf proliferation inhibition EC50 uM>
0.437

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
32.47

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3468
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 18 28  1  0  0  0  0
 22 28  1  0  0  0  0
M  CHG  1  22   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3468

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1OC)C(=O)OCCC2CCC[N+]3(C)CCCCC23

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.345

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-347
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -2.1730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -3.6020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 12 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  2  0  0  0  0
 11 32  4  0  0  0  0
  6 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
M  CHG  2  29   1  30  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-347

>  <JC_XSMILES>
COC1=CC=C2N=C(C)C=C(N(C3=CC=C(Br)C=C3)S(=O)(=O)C4=CC=C(C=C4)[N+]([O-])=O)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.647

>  <W2 Pf proliferation inhibition EC50 uM>
1.049

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.83

>  <Powder data?>
Yes

>  <IFI value>
0.042553191

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3470
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    3.6182   -2.7209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8335   -2.4660    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0885   -1.6814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5786   -3.2506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489   -2.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227   -3.3151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878   -3.3762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8913    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7163    2.8744    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8913    2.0494    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8913    3.6994    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 13 18  4  0  0  0  0
 11 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 34 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3470

>  <JC_XSMILES>
CC(C)(C)CC(C)(C)NC1=C(N=C2C=CC=CN12)C3=CC=CC=C3OC(=O)C4=CC=CC(=C4)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.957

>  <W2 Pf proliferation inhibition EC50 uM>
0.1339

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3471
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    0.5269   -3.0225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -2.6420    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -1.9275    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -1.3144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9252   -0.5075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3121    0.0446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4836    0.8515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2683    1.1065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4398    1.9134    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8814    0.5544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7098   -0.2525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3229   -0.8046    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
  6 12  4  0  0  0  0
 12 13  1  0  0  0  0
  5 14  4  0  0  0  0
  2 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3471

>  <JC_XSMILES>
CC1=NOC(C2=CC=C(O)C=C2O)=C1C3=CC=C4OCCOC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2483

>  <W2 Pf proliferation inhibition EC50 uM>
0.2038

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.24

>  <Powder data?>
Yes

>  <IFI value>
0.060240964

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3475
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -9.1491   10.6574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3286   10.5712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9931    9.8175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8437   11.2386    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1793   11.9923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6944   12.6597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8739   12.5735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5383   11.8198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7178   11.7336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3823   10.9799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5618   10.8937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2262   10.1400    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4058   10.0538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0702    9.3001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5551    8.6327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3756    8.7189    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7112    9.4726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2196    7.8790    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4126    7.7075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3264    6.8870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0800    6.5514    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6321    7.1645    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6119    6.4745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6119    5.6495    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8974    6.8870    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830    6.4745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315    6.8870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2460    6.4745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9605    6.8870    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8672   10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6877   10.3987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0232   11.1524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 10 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
  4 32  1  0  0  0  0
  8 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3475

>  <JC_XSMILES>
CC(C)N1CCCC2=CC(CN3CCC(CC3)N4C=C(N=N4)C(=O)NCCCO)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.1335

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.026086957

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3478
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    0.0000    5.7750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4559   -4.0144    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
  5 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
  2 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3478

>  <JC_XSMILES>
ClC1=CC=C(NC(=O)C2=CC=C(C=C2)C3=NC(=CS3)C4=CC=CC=C4Cl)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1497

>  <W2 Pf proliferation inhibition EC50 uM>
0.1057

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>7.93

>  <Powder data?>
No

>  <IFI value>
0.066666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3480
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -1.6139    0.3431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0619    0.9561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2549    0.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2971    1.3977    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7224   -1.3819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -2.0964    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5474   -1.3819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0323   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7774    0.0702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8170   -0.9694    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8170   -1.7944    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0323   -2.0493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7774   -2.8340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9704   -3.0055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7155   -3.7901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2675   -4.4032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0745   -4.2317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3294   -3.4471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3349    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  5 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3480

>  <JC_XSMILES>
COC(=O)C1=C(NC(=O)C2=C(C)ON=C2C3=CC=CC=C3)SC4=C1CCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.977

>  <W2 Pf proliferation inhibition EC50 uM>
1.33

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.014492754

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3483
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 15 25  4  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3483

>  <JC_XSMILES>
COC1=CC=CC=C1CNC(=O)CCN2C(=O)NC3=CC=CC=C3C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.537

>  <W2 Pf proliferation inhibition EC50 uM>
0.1326

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.016666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3484
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 10 23  4  0  0  0  0
 14 23  4  0  0  0  0
  5 24  1  0  0  0  0
 24 25  1  0  0  0  0
  2 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3484

>  <JC_XSMILES>
CN1CCN(CCCNC2=CC=NC3=CC4=CC=CC=C4C=C23)CC1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02407

>  <W2 Pf proliferation inhibition EC50 uM>
0.0785

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.93

>  <Powder data?>
Yes

>  <IFI value>
0.187969925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3489
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
 15 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 13 30  4  0  0  0  0
 30 31  4  0  0  0  0
  9 31  4  0  0  0  0
M  CHG  2  25   1  26  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3489

>  <JC_XSMILES>
CCN1CCN(CC1)C2=CC(C)=C3C=C(NC(=O)C4=CC=CC(=C4)[N+]([O-])=O)C=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.096

>  <W2 Pf proliferation inhibition EC50 uM>
0.2674

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.26

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3490
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  4  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
  2 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3490

>  <JC_XSMILES>
NC(=NOC(=O)C1=CC=CC=C1I)C2=CC=CC=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
6.03

>  <W2 Pf proliferation inhibition EC50 uM>
0.831

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
62.98

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3491
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    6.4302    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  4  0  0  0  0
 13 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3491

>  <JC_XSMILES>
NCCCCCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2881

>  <W2 Pf proliferation inhibition EC50 uM>
0.1319

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019047619

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3492
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -3.6884   -0.3968    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6705    0.4280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3759    0.8559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3580    1.6807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6348    2.0776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9294    1.6498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9473    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2419    0.3971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5187    0.7940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5008    1.6188    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7653    0.3369    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2622    0.3731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2791   -0.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0497   -0.8176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8029   -0.4811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0976    0.2895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7611    1.0427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9905    1.3374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2373    1.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7507    0.2525    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2015    0.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8627   -0.6168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6638   -1.4174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1291   -1.6455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3280   -2.4462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2660   -3.0188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0588   -2.7907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2577   -1.9900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 12 19  1  0  0  0  0
 18 20  1  0  0  0  0
 14 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3492

>  <JC_XSMILES>
FC1=CC=CC=C1NC(=O)NC2CC3CCCC(C2)N3CCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.44

>  <W2 Pf proliferation inhibition EC50 uM>
0.1398

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.61

>  <Powder data?>
No

>  <IFI value>
0.012987013

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3495
  Mrv1591402191617072D          

 15 16  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
  5 14  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3495

>  <JC_XSMILES>
CN(C)\C=C1/OC2=CC=CC=C2N=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1526

>  <W2 Pf proliferation inhibition EC50 uM>
0.1315

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.026315789

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3496
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  9  6  1  4  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 16 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3496

>  <JC_XSMILES>
COC1=CC=C(C=C1)C=NNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2754

>  <W2 Pf proliferation inhibition EC50 uM>
0.2065

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.71

>  <Powder data?>
Yes

>  <IFI value>
0.048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3498
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    1.8500    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1542   -0.3497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6080   -0.6654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3702   -0.3497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6859    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3702    1.1747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6080    1.4904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1542    1.1747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 21 28  1  0  0  0  0
 20 29  1  0  0  0  0
 16 29  1  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3498

>  <JC_XSMILES>
CCNC(=O)C1CCN(CC1)C2=CC=CC3=C2C(=O)N(C4CCCCCCC4)C3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.746

>  <W2 Pf proliferation inhibition EC50 uM>
1.314

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034482759

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3499
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -2.3338    1.3553    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.5268    1.5268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5268    2.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8123    2.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0979    2.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0979    1.5268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8123    1.1143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8123    0.2893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8123   -0.5357    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1449   -1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3998   -1.8052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2248   -1.8052    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4798   -1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0127    0.2893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4252    1.0038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2502    1.0038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6627    0.2893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2502   -0.4252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4252   -0.4252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6373    0.2893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0498   -0.4252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8748   -0.4252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2873    0.2893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8748    1.0038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0498    1.0038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
  8 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
  8 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3499

>  <JC_XSMILES>
ClC1=CC=CC=C1C(N2C=CN=C2)(C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2802

>  <W2 Pf proliferation inhibition EC50 uM>
0.338

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
25.8

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-350
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  4 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
  8 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
  2 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-350

>  <JC_XSMILES>
CC(CC1=NC2=CC(=CC=C2CN1CC3CCCCC3)C(=O)NCC=C)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.529

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.025

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3502
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    2.6378    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1088    1.7959    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.7732    1.0422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1857    0.3278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7732   -0.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9482   -0.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5357   -1.1012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7107   -1.1012    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.9482   -1.8156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7732   -1.8156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1857   -1.1012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0107   -1.1012    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9528    1.1285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4007    0.5154    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  4  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 12 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
 10 24  4  0  0  0  0
 24 25  1  0  0  0  0
  6 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 29 33  4  0  0  0  0
 33 34  4  0  0  0  0
 26 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3502

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N=c2sc(=CC3=CC(Cl)=CC=C3O)c(=O)n2C1C4=CC=C5OCOC5=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
4.93

>  <W2 Pf proliferation inhibition EC50 uM>
1.307

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3506
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    3.3523   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5433   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1067   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9317   -1.9354    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
 10 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   9
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3506

>  <JC_XSMILES>
OC1=C2CCCCC2=NC3=CC(=NN13)C4=CC=C(Br)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.522

>  <W2 Pf proliferation inhibition EC50 uM>
1.302

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.095238095

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3507
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -1.4762   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7618   -2.2506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -3.4881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7618   -3.9006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6672   -2.2506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6672   -1.4256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3816   -2.6631    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0961   -2.2506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1823   -1.4302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7698   -0.7157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3219   -0.1026    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1503    0.7044    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0756   -0.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9893   -1.2586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4018   -1.9731    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8498   -2.5862    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0213   -3.3932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8059   -3.6481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9775   -4.4551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3644   -5.0071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5797   -4.7522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9666   -5.3042    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.4082   -3.9452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3507

>  <JC_XSMILES>
CCC(CC)C(=O)NC1=C2CS(=O)CC2=NN1C3=CC=CC(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
11.89

>  <W2 Pf proliferation inhibition EC50 uM>
1.3

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3508
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
   -0.5772   -2.4836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -2.8960    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -3.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.1336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.9586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2915   -5.3711    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2915   -6.1961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5770   -6.6086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5769   -7.4336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2914   -7.8461    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0059   -7.4337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7203   -7.8462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4348   -7.4337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1493   -7.8463    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.4349   -6.6087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7204   -6.1962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0059   -6.6087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -2.4835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5662   -2.8960    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -1.6585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -1.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5873   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -0.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
 23 24  1  0  0  0  0
 22 27  1  0  0  0  0
 20 28  1  0  0  0  0
 26 27  1  0  0  0  0
 24 29  1  0  0  0  0
 26 28  1  0  0  0  0
 25 26  1  0  0  0  0
 20 29  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3508

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C34CC5CC(CC(C5)C3)C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.053

>  <W2 Pf proliferation inhibition EC50 uM>
0.1836

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.13

>  <Powder data?>
No

>  <IFI value>
0.03

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3509
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -10.7250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -11.1375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270  -10.4230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020  -11.8520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -11.1375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -4.2868  -11.5500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.5724  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
  6 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
  3 32  4  0  0  0  0
M  CHG  2  26   1  27  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3509

>  <JC_XSMILES>
COC1=CC=C(NC(=O)CN2CCN(CC2)S(=O)(=O)C3=CC=CC(=C3)[N+]([O-])=O)C(OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.299

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3511
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -1.4087   -7.1282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -7.1282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663   -5.6992    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489    0.8152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227    1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    1.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175    3.0199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483    2.5100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 28 31  1  0  0  0  0
 22 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 35 37  4  0  0  0  0
 37 38  4  0  0  0  0
 32 38  4  0  0  0  0
 38 39  4  0  0  0  0
 21 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3511

>  <JC_XSMILES>
CCCCOC1=CC=C(C=C1)C(=O)OC2=CC=CC=C2C3=C(NC(C)(C)CC(C)(C)C)N4C=CC(C)=CC4=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.804

>  <W2 Pf proliferation inhibition EC50 uM>
0.1297

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.046728972

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3512
  Mrv1591402191617072D          

 14 14  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3512

>  <JC_XSMILES>
CC1=CC=C(C=C1)C(C)=NNC(N)=N

>  <PF proliferation inhibition 3D7 EC50 uM>
2.035

>  <W2 Pf proliferation inhibition EC50 uM>
0.2504

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.33

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3515
  Mrv1591402191617072D          

 15 16  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  2  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  2 15  4  0  0  0  0
 10 15  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3515

>  <JC_XSMILES>
CC1=NC(NC(N)=N)=NC2=CC=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.887

>  <W2 Pf proliferation inhibition EC50 uM>
0.858

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
66.41

>  <Powder data?>
Yes

>  <IFI value>
0.005847953

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3518
  Mrv1591402191617072D          

 44 47  0  0  0  0            999 V2000
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0392   -4.0481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2107   -4.8550    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5912   -3.4350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1787   -2.7205    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6282   -2.8920    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4117   -3.5212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8966   -2.8538    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7473   -4.2749    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 14 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 29 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  1  0  0  0  0
 13 35  1  0  0  0  0
 35 36  2  0  0  0  0
 35 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 39 44  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3518

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1OC)C(N(C(=O)C2=C(N)C(=NS2)C(N)=O)C3=CC=C(C=C3)C(C)C)C(=O)NCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.448

>  <W2 Pf proliferation inhibition EC50 uM>
1.29

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.054545455

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-352
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    7.0714    0.6979    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    6.3569    1.1104    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.3569    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1970    3.0624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6095    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 14 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 23  1  0  0  0  0
  8 24  4  0  0  0  0
  4 24  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-352

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(CSC2=NC3=C(SC=C3)C(=O)N2C4CC4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.522

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3520
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  3 17  4  0  0  0  0
  7 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3520

>  <JC_XSMILES>
COC1=CC=CC2=C(C)N=C(NC(N)=N)N=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2912

>  <W2 Pf proliferation inhibition EC50 uM>
0.688

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
53.47

>  <Powder data?>
Yes

>  <IFI value>
0.046153846

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3523
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
   -7.8592   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
  7 15  4  0  0  0  0
 15 16  4  0  0  0  0
  4 16  4  0  0  0  0
  2 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 31 36  1  0  0  0  0
 29 37  4  0  0  0  0
 37 38  4  0  0  0  0
 26 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3523

>  <JC_XSMILES>
O=C(NC1=CC=C(CC2=NCCCN2)C=C1)C3=CC=C(C=C3)C(=O)NC4=CC=C(CC5=NCCCN5)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1268

>  <W2 Pf proliferation inhibition EC50 uM>
0.1285

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017699115

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3525
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3525

>  <JC_XSMILES>
CC1=CC(I)=CC=C1NC(=O)CNC(=O)OCC2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.284

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3527
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042    2.3236    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757    3.1306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612    3.5431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481    2.9911    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3294    3.4662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9968    2.9813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7505    3.3168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8367    4.1373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1693    4.6222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4156    4.2867    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  8 21  4  0  0  0  0
 21 22  4  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
  3 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3527

>  <JC_XSMILES>
COC1=CC=C2N=C(NC3=NC(=CS3)C4=CC=CC=N4)SC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0918

>  <W2 Pf proliferation inhibition EC50 uM>
0.0935

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.31

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3529
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -1.4289   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3529

>  <JC_XSMILES>
ClC1=CC=C(CNC(=O)C(=O)NCC2=CC=CC=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.319

>  <W2 Pf proliferation inhibition EC50 uM>
0.1053

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.24

>  <Powder data?>
No

>  <IFI value>
0.015384615

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-353
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    4.3172   -1.0051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2611   -0.1820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0814   -0.2697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4602   -0.3801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8882    0.2143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6594   -0.5783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8585   -0.7765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6297   -1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2018   -2.1636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9729   -2.9562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1721   -3.1544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6001   -2.5599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8289   -1.7672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2865   -0.1820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4857   -0.3801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0864    0.2143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8872    0.0162    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.1424    1.0070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4296    1.6015    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9433    1.2051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5153    0.6107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3162    0.8088    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1170    1.0070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9179    1.2051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4899    0.6107    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1467    1.9978    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5746    2.5922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8035    3.3849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2314    3.9794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  7 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 14 21  4  0  0  0  0
 21 22  1  0  0  0  0
  5 22  1  0  0  0  0
  5 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
  2 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-353

>  <JC_XSMILES>
CC1(C)CC2(CC(C3=CC=CC=C3)C4=CC(Cl)=C(O)C=C4O2)N=C(N1)SCC=C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.192

>  <W2 Pf proliferation inhibition EC50 uM>
1.52

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3532
  Mrv1591402191617072D          

 47 53  0  0  0  0            999 V2000
    8.8444    1.3941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0374    1.5657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4854    0.9526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6784    1.1241    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4235    1.9087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9755    2.5218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7825    2.3503    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3345    2.9634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1415    2.7919    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.0796    3.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6316    4.3611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3766    5.1457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9287    5.7588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7357    5.5873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9906    4.8027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4386    4.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2726    3.9195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7206    3.3064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9136    3.4780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6586    4.2626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2107    4.8757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0176    4.7042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3813   -0.2736    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0645    1.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -1.5105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195   -1.9230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195   -2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050   -3.1605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095   -2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095   -1.9230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050   -1.5105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 10 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  4 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 32 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 36 41  4  0  0  0  0
 34 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 31 47  4  0  0  0  0
 42 47  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3532

>  <JC_XSMILES>
CC1CN(CCN1C(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)C(C)SC4=NN=C5C(=N4)N(CC6=CC=CC=C6)C7=CC=CC=C57

>  <PF proliferation inhibition 3D7 EC50 uM>
0.914

>  <W2 Pf proliferation inhibition EC50 uM>
0.1269

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3533
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
  9 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3533

>  <JC_XSMILES>
CCC1=CC=CC=C1N(CC(=O)NC2CCCCC2)C(=O)CCC(=O)NC3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.835

>  <W2 Pf proliferation inhibition EC50 uM>
1.268

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3535
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
  5 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
  4 25  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3535

>  <JC_XSMILES>
CN(C)C1=C(N(C(C)=O)C2=CC=C(Cl)C=C2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.03137

>  <W2 Pf proliferation inhibition EC50 uM>
0.0691

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.46

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3536
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.7750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434    6.1875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145    6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  9  8  1  4  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 14 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 12 27  4  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 28 34  1  0  0  0  0
  6 35  1  0  0  0  0
 35 36  1  0  0  0  0
 35 37  2  0  0  0  0
M  CHG  4  22   1  23  -1  35   1  36  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3536

>  <JC_XSMILES>
COC1=CC=C(C=C1C=NNC2=NC(NC3=CC=C(C=C3)[N+]([O-])=O)=NC(=N2)N4CCN(C)CC4)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.859

>  <W2 Pf proliferation inhibition EC50 uM>
0.388

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
30.69

>  <Powder data?>
Yes

>  <IFI value>
0.039473684

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3537
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    6.4121   -0.5472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6358   -0.8265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0058   -0.2939    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2295   -0.5732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0833   -1.3851    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5995   -0.0406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6601    0.7822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3613    1.2168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8963    1.0941    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3637    0.4640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7983   -0.2372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4083   -0.9642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5837   -0.9900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1937   -1.7170    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1491   -0.2887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3245   -0.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1101    0.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2799    1.1137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1045    1.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391    0.4383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   9
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3537

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C1C=C(O)C3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0986

>  <W2 Pf proliferation inhibition EC50 uM>
0.1263

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.031055901

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3538
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  6 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 11 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 10 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3538

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=N3)C(=O)CC(C)(C)C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.263

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022988506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3544
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -1.0079    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2934    4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2934    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
 10  7  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3544

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)C=NNC2=NC=NC3=C2N=CN3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1671

>  <W2 Pf proliferation inhibition EC50 uM>
0.138

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.97

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3546
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    2.7389   -5.9280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7389   -6.7530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4063   -7.2379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1514   -8.0225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -8.0225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0714   -7.2379    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -8.6899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -9.4746    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9595    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -9.4746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -8.6899    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -9.7295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1946  -10.5365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9793  -10.7914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5924  -10.2394    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -9.4324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -9.1775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3770  -10.4943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9901   -9.9423    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5485  -11.3013    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3331  -11.5562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5047  -12.3632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2893  -12.6181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9024  -12.0661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7308  -11.2591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9462  -11.0042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6870  -12.3210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4716  -12.5760    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  7 11  4  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 24 27  1  0  0  0  0
 27 28  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3546

>  <JC_XSMILES>
CC1=CC=C(O1)C2=NOC(=N2)C3CCN(CC3)C(=O)NC4=CC=C(C=C4)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
1.304

>  <W2 Pf proliferation inhibition EC50 uM>
1.257

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3548
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    4.1531    2.7018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5932    2.0959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7704    2.1558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3042    2.8365    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5457    3.6253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3131    3.9284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0284    3.5174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8701    4.0988    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2111    3.6026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4793    2.8224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9378    2.2000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1281    2.3577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1402    3.1379    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4013    3.7603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1330    4.5405    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6768    4.6982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9451    5.4784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4036    6.1008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4062    5.9431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6745    5.1629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6719    6.8810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4816    7.0387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7499    7.8189    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2084    8.4413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3987    8.2835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1304    7.5034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  1  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3548

>  <JC_XSMILES>
C1CCN2C(CC1)=NC3=C2N=CN=C3N4CCC(=CC4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.294

>  <W2 Pf proliferation inhibition EC50 uM>
1.077

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>85.84

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-355
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    2.4526    3.3824    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8872    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3218    1.9800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9318    1.2530    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3664    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1910    0.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6256   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4502   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8849   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4949   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6703   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2357   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4111   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8784   -1.5066    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1147   -1.1947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4134   -1.6293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6864   -1.2393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0148   -1.6739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0754   -2.4967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8766   -2.6934    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3112   -1.9921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1232   -1.8459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4025   -1.0696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8699   -0.4396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0579   -0.5858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7786   -1.3621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1752   -0.3719    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9765   -0.1753    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  3  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 18 26  4  0  0  0  0
 21 26  4  0  0  0  0
 15 27  4  0  0  0  0
 27 28  4  0  0  0  0
  5 28  4  0  0  0  0
 13 28  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-355

>  <JC_XSMILES>
N#CCSC1=NC2=CC=CC=C2C3=NC(CCC4=CNC5=CC=CC=C45)=NN13

>  <PF proliferation inhibition 3D7 EC50 uM>
3.87

>  <W2 Pf proliferation inhibition EC50 uM>
3.85

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
25.41

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3550
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2474   -3.5195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1868   -3.5195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 12 20  4  0  0  0  0
 20 21  4  0  0  0  0
  9 21  4  0  0  0  0
  7 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3550

>  <JC_XSMILES>
CC1=CC=C2N=C(NC3=NC=C4C(=O)CC(C)(C)CC4=N3)N=C(C)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.253

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3552
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -1.7505   -6.3241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2354   -5.6567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8999   -4.9030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3848   -4.2356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0492   -3.4819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2288   -3.3957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7438   -4.0631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0794   -4.8168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -1.9275    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -1.3144    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -2.4705    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 14 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3552

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=NOC(=N2)N3CCC4=CC=CC=C4C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1998

>  <W2 Pf proliferation inhibition EC50 uM>
0.1251

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3553
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    4.9279   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6881    3.6579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9431    4.4425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7681    4.4425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0230    3.6579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8076    3.4029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4207    3.9550    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3553

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=NC3=CC=NN3C(=C2)N4CCCC4CO

>  <PF proliferation inhibition 3D7 EC50 uM>
1.143

>  <W2 Pf proliferation inhibition EC50 uM>
1.251

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3559
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    6.3813    1.0986    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.3140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.1425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.7556    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435   -1.1567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.6784   -0.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4854   -0.1276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0374   -0.7407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7825   -1.5253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3345   -2.1384    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.9755   -1.6968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7206   -2.4814    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4235   -1.0837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
  5 11  4  0  0  0  0
  8 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
  7 18  4  0  0  0  0
  2 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 19 26  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3559

>  <JC_XSMILES>
OC(CSC1=NC2=C(C(=O)N1)C3=CC=CC=C3S2)C4=CC=C(Cl)C(Cl)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.663

>  <W2 Pf proliferation inhibition EC50 uM>
0.1243

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037313433

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3561
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
   -5.1659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7858   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7858   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -3.5854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 26 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 19 35  4  0  0  0  0
 14 35  4  0  0  0  0
 35 36  2  0  0  0  0
  7 37  4  0  0  0  0
  3 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3561

>  <JC_XSMILES>
COC1=CC=CC(NC(=O)C2=C(C)C3=C(S2)N=CN(CC(=O)N4CCN(CC4)C5=CC=CC=N5)C3=O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.238

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3566
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5152   -2.4705    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3221   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7346   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1826   -1.3144    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
  6 11  4  0  0  0  0
  3 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 12 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
M  CHG  2  25   1  26  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3566

>  <JC_XSMILES>
OC1=C(C=CC2=CC=CN=C12)C(NC3=NC=CS3)C4=CC=CC(=C4)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2939

>  <W2 Pf proliferation inhibition EC50 uM>
0.1983

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.08

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3567
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
 13 24  4  0  0  0  0
  9 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  4  0  0  0  0
 25 35  4  0  0  0  0
 35 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3567

>  <JC_XSMILES>
COC1=CC=CC=C1C(NC(=O)C2=CC(OC)=C(OC)C(OC)=C2)C3=CC(Cl)=C4C=CC=NC4=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.204

>  <W2 Pf proliferation inhibition EC50 uM>
1.232

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3569
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    2.0701   -0.5396    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -0.5422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083   -1.4984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604   -0.8853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -0.1006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    3.5854    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  2  0  0  0  0
 21 23  4  0  0  0  0
  8 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3569

>  <JC_XSMILES>
FC1=CC=CC=C1C2=NC3=C(C=NN3C4=CC=CC=C4)C(=O)N2C5=CC=C(Br)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
6.79

>  <W2 Pf proliferation inhibition EC50 uM>
1.23

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.02247191

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-357
  Mrv1591402191617072D          

 39 45  0  0  0  0            999 V2000
   -0.2211   -8.7458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6336   -8.0314    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2211   -7.3169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6336   -6.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2211   -5.8880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -5.8880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -6.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -7.3169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -5.1735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -5.1735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -4.4590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -4.4590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.6653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.4903    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8810   -2.7050    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -5.8880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789   -5.8880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4914   -6.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789   -7.3169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4914   -8.0314    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789   -8.7458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -7.3169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -6.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  2  0  0  0  0
 13 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 12 20  1  0  0  0  0
 20 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 22 31  4  0  0  0  0
 26 31  4  0  0  0  0
 10 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 35 38  4  0  0  0  0
 38 39  4  0  0  0  0
 32 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-357

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C(C3C4C(C2C3=O)C(=O)N(C4=O)C5=CC=CC6=CC=CC=C56)C7=CC=C(OC)C=C7

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.093

>  <W2 Pf proliferation inhibition EC50 uM>
>1.51

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3571
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4681   -1.5731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0202   -0.9600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6077   -0.2455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007   -0.4170    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 16 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  4  0  0  0  0
 22 32  4  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3571

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1OC)C(=O)NC(C2=CC=CS2)C3=CC(Cl)=C4C=CC=NC4=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.486

>  <W2 Pf proliferation inhibition EC50 uM>
1.226

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3573
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
 13 22  4  0  0  0  0
 10 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3573

>  <JC_XSMILES>
CCN1CCN(CC1)C2=C(C=NC3=CC(OC)=C(OC)C=C23)C(=O)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
3.022

>  <W2 Pf proliferation inhibition EC50 uM>
1.225

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022222222

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3575
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0977   -6.6724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427   -7.4570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0177   -7.4570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7628   -6.6724    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  3  0  0  0  0
 13 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 16 22  4  0  0  0  0
  9 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3575

>  <JC_XSMILES>
CCCOC(=O)CSC1=NC(N)=C(C#N)C(C2=CC=CO2)=C1C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
1.891

>  <W2 Pf proliferation inhibition EC50 uM>
1.221

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.061538462

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3576
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -7.0380    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380    1.4652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    2.7027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    2.7027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    1.4652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    3.1152    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7676    2.4007    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5926    3.8297    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    3.5277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    1.8777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    1.8777    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.1848    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6548   -0.6697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9097   -1.4544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7347   -1.4544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9897   -0.6697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  1  0  0  0  0
 21 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3576

>  <JC_XSMILES>
COC1=CC=C(C=C1)S(=O)(=O)N2CCCCC2C(=O)NC(CN3CCCC3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1684

>  <W2 Pf proliferation inhibition EC50 uM>
0.1221

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009708738

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3578
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -4.2962    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.8744    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.9979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 22 29  4  0  0  0  0
 17 29  4  0  0  0  0
 29 30  1  0  0  0  0
 15 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3578

>  <JC_XSMILES>
COC1=CC(OC)=CC(=C1)C(=O)NCC2CC3=CC(Cl)=CC(C4=CC=NC=C4)=C3O2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.368

>  <W2 Pf proliferation inhibition EC50 uM>
0.537

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
44.06

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-358
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2695    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
  9 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-358

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2N3N=NN=C3NC(C)=C2C(=O)OC4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
>10

>  <W2 Pf proliferation inhibition EC50 uM>
>11.18

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>74.09

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3580
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
    6.2102    3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    4.8229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    6.8854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    7.2979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    6.8854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    8.1229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    8.5354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    9.3604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    9.7729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    9.3604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    8.5354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    8.1229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  5 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 26 30  4  0  0  0  0
 30 31  4  0  0  0  0
 23 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3580

>  <JC_XSMILES>
OC1=CC=C(C=C1CNC2CCN(CC2)CC3=CC=CC=C3)C4=CC=C5OCOC5=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.598

>  <W2 Pf proliferation inhibition EC50 uM>
0.364

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
29.91

>  <Powder data?>
Yes

>  <IFI value>
0.019607843

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3581
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 21 27  1  0  0  0  0
  8 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 36 39  4  0  0  0  0
 30 39  4  0  0  0  0
  6 40  4  0  0  0  0
 40 41  4  0  0  0  0
  3 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3581

>  <JC_XSMILES>
COC1=CC=C(CN(CC2=CC3=CC=CC(C)=C3N=C2N4CCCC(O)C4)C(=O)C5=CC=C(OC)C(OC)=C5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.422

>  <W2 Pf proliferation inhibition EC50 uM>
1.215

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.029411765

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3582
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    6.9126    2.7616    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.1289    3.0193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9603    3.8269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1766    4.0847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5615    3.5349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7301    2.7273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5138    2.4695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6824    1.6619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4832    1.4634    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.8273    0.7136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6509    0.7600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1029    0.0698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7312   -0.6667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9076   -0.7131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4556   -0.0229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6480   -0.1915    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0126    0.3348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0279    1.1596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2482    1.4291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0079    2.2183    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7510    0.7708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9290    0.6998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5795   -0.0475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0520   -0.7239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8739   -0.6529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2234    0.0944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
  8 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 17 26  1  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3582

>  <JC_XSMILES>
FC1=CC=CC=C1C2SC3=CC=CC=C3N=C4C2C(=O)C5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2088

>  <W2 Pf proliferation inhibition EC50 uM>
0.2782

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
22.92

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3588
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
   -3.0587   -4.2703    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  8  5  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3588

>  <JC_XSMILES>
BrC1=CC=C(C=C1)C=NNC2=NC3=CC=CC=C3N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2255

>  <W2 Pf proliferation inhibition EC50 uM>
0.674

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
55.83

>  <Powder data?>
Yes

>  <IFI value>
0.090163934

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3589
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    9.1241    2.3582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5145    1.8023    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7283    2.0522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1187    1.4963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3325    1.7463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7229    1.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9367    1.4403    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8667    2.2624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2360    2.7942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1662    1.6853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5828    0.7397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4049    0.8096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9521    1.2715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2752    0.7999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5283    1.1503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4584    1.9723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1353    2.4439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0654    3.2660    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8822    2.0935    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4140    2.7242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1558    2.5522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7654    3.1081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5516    2.8581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1612    3.4140    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  2  0  0  0  0
 17 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  1  0  0  0  0
  9 20  1  0  0  0  0
  5 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  3 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3589

>  <JC_XSMILES>
COC1=CC(CN2CC3CC(C2)C4=CC=CC(=O)N4C3)=CC=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.206

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3592
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 16 26  4  0  0  0  0
 11 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3592

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CNCC3CCCCC3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.35

>  <W2 Pf proliferation inhibition EC50 uM>
0.1201

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3595
  Mrv1591402191617072D          

 24 28  0  0  0  0            999 V2000
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1369   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6218   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1369   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4468   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8593    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6843    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0968   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6843   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8593   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  4  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  1  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  5 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  4 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1   1
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  18
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3595

>  <JC_XSMILES>
N1C2=CC3=C(C=C2N=C1C4=CC=CC=C4)N=C(N3)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2853

>  <W2 Pf proliferation inhibition EC50 uM>
1.199

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.088709677

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3596
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.7145    6.7661    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.9812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    2.1965    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.9812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376    3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091    4.0431    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507    2.6841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353    2.9390    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8027    2.4541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4702    2.9390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2152    3.7236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3902    3.7236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119    1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4369    1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6918    0.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0244    0.2595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3570    0.7445    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  8 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 10 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3596

>  <JC_XSMILES>
FC1=CC=C(C=C1)C2CC(=NN2C(=O)CN3CCCC3)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.196

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-360
  Mrv1591402191617072D          

 54 60  0  0  0  0            999 V2000
    3.2789    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.9947    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9947    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7092    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4236    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1381    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8526    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8526    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1381    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4236    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051   -1.0164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2426   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6551   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4801   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8926   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7176   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1301    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7176    1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9551    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3676    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1926    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.6051    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1926    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3676    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9551    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4801    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6551    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 10 21  4  0  0  0  0
 21 22  4  0  0  0  0
  7 22  4  0  0  0  0
  3 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
 28 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  2  0  0  0  0
 35 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 42 43  2  0  0  0  0
 42 44  1  0  0  0  0
 44 45  1  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 48 49  4  0  0  0  0
 49 50  4  0  0  0  0
 45 50  4  0  0  0  0
 40 51  4  0  0  0  0
 51 52  4  0  0  0  0
 37 52  4  0  0  0  0
 33 53  4  0  0  0  0
 53 54  4  0  0  0  0
 30 54  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  27
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-360

>  <JC_XSMILES>
ClC1=C(NC(=O)C2=CC=C(NC(=O)CC3=CC=CC=C3)C=C2)C=CC4=C1NC(=N4)C5=CC=C(NC(=O)C6=CC=C(NC(=O)CC7=CC=CC=C7)C=C6)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
8

>  <W2 Pf proliferation inhibition EC50 uM>
6.02

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
39.95

>  <Powder data?>
Yes

>  <IFI value>
0.075757576

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3600
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
  5 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
  4 25  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3600

>  <JC_XSMILES>
CN(C)C1=C(N(C(C)=O)C2=CC=C(F)C=C2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02442

>  <W2 Pf proliferation inhibition EC50 uM>
0.032

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.681

>  <Powder data?>
Yes

>  <IFI value>
0.310810811

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3603
  Mrv1591402191617072D          

 46 51  0  0  0  0            999 V2000
    4.5632   -2.6300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8488   -3.0425    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1343   -2.6300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4198   -3.0425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7054   -2.6300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7054   -1.8050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4198   -1.3925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4198   -0.5675    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.1343   -1.8050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8488   -1.3925    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8488   -0.5675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5632   -0.1550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5632    0.6700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2777    1.0825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9922    0.6700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9922   -0.1550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2777   -0.5675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9909   -3.0425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9909   -3.8675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6583   -4.3524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4430   -4.0975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4034   -5.1370    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8883   -5.8045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5784   -5.1370    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3235   -4.3524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4612   -4.0975    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0935   -5.8045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4290   -6.5581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0559   -7.2256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8764   -7.1393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2119   -6.3857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7270   -5.7182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2764   -2.6300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4773   -2.9655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6488   -3.7725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0293   -2.3524    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8498   -2.4387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6168   -1.6380    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1902   -1.8095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8033   -1.2575    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9523   -0.8843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7728   -0.7981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1084   -0.0444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6235    0.6230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8030    0.5368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4674   -0.2169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  3  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  5 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 25 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 18 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  1  0  0  0  0
 36 38  4  0  0  0  0
 38 39  4  0  0  0  0
 33 39  4  0  0  0  0
 39 40  2  0  0  0  0
 38 41  1  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 41 46  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3603

>  <JC_XSMILES>
COC1=CC(=CC(Cl)=C1OCC2=CC=CC=C2)C(C3=C(C)N(C)N(C3=O)C4=CC=CC=C4)C5=C(C)N(C)N(C5=O)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
2.695

>  <W2 Pf proliferation inhibition EC50 uM>
0.456

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
38.31

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3604
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    4.7086   -5.5844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9635   -4.7998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4115   -4.1867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6664   -3.4021    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1815   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6664   -2.0672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4115   -1.2826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9635   -0.6695    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7086    0.1151    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2606    0.7282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0891    1.5352    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8035    1.9477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9751    2.7547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7597    3.0096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3728    2.4576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2012    1.6506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4166    1.3957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0811    0.6420    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4510   -2.3221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1655   -1.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8800   -2.3221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8800   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1655   -3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4510   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  7  6  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
  6 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3604

>  <JC_XSMILES>
C=CCN1C=C(C=NNC2=NC3=CC=CC=C3N2)C4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0913

>  <W2 Pf proliferation inhibition EC50 uM>
0.2195

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.45

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3605
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -3.0686   -2.3800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8971   -1.5731    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4491   -0.9600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0366   -0.2455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2296   -0.4170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -1.1270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    0.3020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3605

>  <JC_XSMILES>
CN1C=NN=C1SCC(=O)NC2=CC=CC=C2C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.188

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-361
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
  7 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
M  CHG  2  17   1  18  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-361

>  <JC_XSMILES>
CC(=O)NC1=CC(=CC=C1N2CCOCC2)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.551

>  <W2 Pf proliferation inhibition EC50 uM>
1.505

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3610
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 16 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3610

>  <JC_XSMILES>
CC(C)C(=O)N(C)CCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1306

>  <W2 Pf proliferation inhibition EC50 uM>
0.1181

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028037383

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3615
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    5.0953    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3615

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4=CC=CC=C4Br

>  <PF proliferation inhibition 3D7 EC50 uM>
0.76

>  <W2 Pf proliferation inhibition EC50 uM>
0.1174

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.021276596

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3617
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
    7.5920   -0.2893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3065    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0209   -0.2893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7354    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4499   -0.2893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1644    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1644    0.9482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4499    1.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4499    2.1857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1644    2.5982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8788    2.1857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8788    1.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1644    3.4232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4499    3.8357    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.8788    3.8357    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.8788    4.6607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1644    5.0732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1644    5.8982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8788    6.3107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5933    5.8982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5933    5.0732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3078    4.6607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0615    4.9963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2330    5.8033    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.0176    6.0582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2725    5.2736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7627    6.8428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.8022    6.3131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.9737    7.1201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.1453    7.9271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.7807    6.9486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.1668    7.2916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.6135    4.3832    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.4385    4.3832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.8510    3.6687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.4385    2.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.8510    2.2398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.6135    2.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2010    3.6687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3940    3.8403    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
 23 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  1  0  0  0  0
 36 38  4  0  0  0  0
 38 39  4  0  0  0  0
 33 39  4  0  0  0  0
 39 40  4  0  0  0  0
 22 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3617

>  <JC_XSMILES>
CCCCCCC1=CC=C(C=C1)C(=O)OC2=CC=CC=C2C3=C(NC(C)(C)CC(C)(C)C)N4C=CC(C)=CC4=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.813

>  <W2 Pf proliferation inhibition EC50 uM>
0.1622

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>13.83

>  <Powder data?>
No

>  <IFI value>
0.021052632

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-362
  Mrv1591402191617072D          

 32 36  0  0  1  0            999 V2000
   -3.9849    0.8570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599    0.8570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9049    0.0724    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2398    0.0724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 15 14  1  0  0  0  0
 15 10  1  0  0  0  0
 15 16  1  6  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 13 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  4  0  0  0  0
 23 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-362

>  <JC_XSMILES>
C1COC(C1)CNCCN2CCN(C[C@@H]2CC3=CC=CC=C3)C4=CC=C5C=CC=CC5=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2725

>  <W2 Pf proliferation inhibition EC50 uM>
0.38

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.537

>  <Powder data?>
No

>  <IFI value>
0.036585366

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3620
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5700    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
  5 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 13 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 12 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3620

>  <JC_XSMILES>
CC(=O)N(C1=CC=CC(Cl)=C1)C2=C(N3CCCCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2387

>  <W2 Pf proliferation inhibition EC50 uM>
0.375

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
32.05

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3623
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1118    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 13 15  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 10 18  4  0  0  0  0
 18 19  4  0  0  0  0
  7 19  4  0  0  0  0
 16 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3623

>  <JC_XSMILES>
CC(C)NC(=O)C1=CC=C2CN(C3CC3)C(=NC2=C1)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.677

>  <W2 Pf proliferation inhibition EC50 uM>
0.1167

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.024691358

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3625
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    3.3988   -2.9672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6538   -2.1826    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1688   -1.5151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6538   -0.8477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3988   -0.0631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9509    0.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7793    1.3570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4938    1.7695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1069    1.2175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7713    0.4638    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5919    0.1085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9788   -0.4436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2643   -0.0311    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5106   -0.3666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    0.7759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9509    1.4433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2864    2.1970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1069    2.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5919    1.6158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2563    0.8621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4384   -1.1026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1529   -0.6901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8673   -1.1026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8673   -1.9276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1529   -2.3401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4384   -1.9276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
  5 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 15 20  4  0  0  0  0
  4 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3625

>  <JC_XSMILES>
CN1C=C(C(C2=CC=CS2)C3=CN(C)C4=CC=CC=C34)C5=CC=CC=C15

>  <PF proliferation inhibition 3D7 EC50 uM>
1.37

>  <W2 Pf proliferation inhibition EC50 uM>
0.61

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
52.31

>  <Powder data?>
Yes

>  <IFI value>
0.175

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3627
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.1599    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587    1.4455    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
  5 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
  3 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3627

>  <JC_XSMILES>
CCC(SC1=NC2=CC=CC=C2N1C(C)=O)C(=O)NC3=NN=C(CS3)C4=CC=C(Br)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.549

>  <W2 Pf proliferation inhibition EC50 uM>
0.543

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
46.66

>  <Powder data?>
Yes

>  <IFI value>
0.057142857

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3628
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    4.2868    1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599    1.9520    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849    0.5230    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  8 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
  5 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3628

>  <JC_XSMILES>
FC(F)(F)C1=CN=C(SC2=NN=C(O2)C3=CC=NC=C3)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.866

>  <W2 Pf proliferation inhibition EC50 uM>
0.976

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
83.89

>  <Powder data?>
Yes

>  <IFI value>
0.1

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3629
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8128   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4628   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  5 14  1  0  0  0  0
  8 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 18 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3629

>  <JC_XSMILES>
CCC(=O)N1CCC2=CC(Br)=CC(=C12)S(=O)(=O)N3CC(C)CC(C)C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.971

>  <W2 Pf proliferation inhibition EC50 uM>
1.162

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3635
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 22 28  4  0  0  0  0
 16 29  4  0  0  0  0
 12 29  4  0  0  0  0
  6 30  4  0  0  0  0
  2 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3635

>  <JC_XSMILES>
CC1=CC=CC(OCC(=O)NC2=CC=CC(NC(=O)COC3=CC=CC(C)=C3)=N2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2374

>  <W2 Pf proliferation inhibition EC50 uM>
1.156

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.029411765

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3636
  Mrv1591402191617072D          

 36 41  0  0  0  0            999 V2000
   -0.4356   -3.7398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0444   -3.0134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4779   -2.3115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0867   -1.5851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7379   -1.5607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1714   -2.2626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7802   -2.9890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1291   -0.8343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7573   -0.0978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3429    0.4834    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4750    1.2977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2903    1.4237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6621    0.6872    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4816    0.5917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9178   -0.1085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6424   -0.8862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8627   -1.1557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1658   -0.7141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0765    0.1060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6677    2.1573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2210    2.8509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5983    3.5846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4223    3.6246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7996    4.3583    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.8690    2.9310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4917    2.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0570    0.0343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3498    0.8057    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5787   -0.6048    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3930   -0.4727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9146   -1.1119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7290   -0.9797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0217   -0.2084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5001    0.4308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6857    0.2986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1641    0.9378    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
  8 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
 13 19  4  0  0  0  0
 12 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
  9 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 35 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3636

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=C(N3C=C(N4CCCCC2=C34)C5=CC=C(Cl)C=C5)C(=O)NC6=CC=CC=C6Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2689

>  <W2 Pf proliferation inhibition EC50 uM>
1.155

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.060606061

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3637
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    8.2717    0.6507    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    8.2717   -0.1743    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    8.9862   -0.5868    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572   -0.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572   -1.4118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427   -1.8243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -1.4118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -0.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427   -0.1743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427    0.6507    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283    1.0632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283    1.8882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427    2.3007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572    1.8882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572    1.0632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427    3.1257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572    3.5382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572    4.3632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717    4.7757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9862    4.3632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9862    3.5382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717    3.1257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427   -2.6493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -3.0618    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572   -3.0618    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572   -3.8868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9697   -4.6013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.6013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  6 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 26 28  1  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3637

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(=CC=C1N2CCC(CC2)CC3=CC=CC=C3)C(=O)NC4CC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2123

>  <W2 Pf proliferation inhibition EC50 uM>
0.619

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
53.73

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3638
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 12 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 21 31  4  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3638

>  <JC_XSMILES>
COC1=CC=CC(=C1)C(=O)NC(C2=CC=CC=C2OC)C3=CC(Cl)=C4C=CC=NC4=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.202

>  <W2 Pf proliferation inhibition EC50 uM>
1.152

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3639
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    0.7177   -6.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3822   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8671   -5.1657    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2890   -4.3257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5924   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0339   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9477   -4.3746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7014   -4.7101    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2534   -4.0971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8409   -3.3826    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
  7 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  6 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 20 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3639

>  <JC_XSMILES>
CCOC(=O)C1=C(CNC(C)C2=CC=CO2)N(N=C1)C3=CC=NC4=CC(Cl)=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.795

>  <W2 Pf proliferation inhibition EC50 uM>
0.448

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
38.93

>  <Powder data?>
Yes

>  <IFI value>
0.025862069

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-364
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   -6.3587   -1.4124    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    2.6021    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
 21 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 19 34  4  0  0  0  0
 34 35  4  0  0  0  0
 17 35  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  35
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-364

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)C3=NC4=CC(NC(=O)C5=CC=C(Cl)C=C5)=CC=C4N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.993

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
83.82

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3641
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  8 16  4  0  0  0  0
 16 17  4  0  0  0  0
  4 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
M  CHG  4   1  -1   2   1  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3641

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(Br)=C(NC2=CC=CC=C2)C(=C1)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1667

>  <W2 Pf proliferation inhibition EC50 uM>
0.0758

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.6

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3642
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    3.8477   -6.8073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0940   -6.4717    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4266   -6.9566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5128   -7.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8454   -8.2620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0917   -7.9265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0054   -7.1060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6729   -6.6211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5866   -5.8006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8330   -5.4650    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2541   -5.3157    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1678   -4.4952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4534   -4.0827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6249   -3.2757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -3.1895    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954   -3.1895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.7605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -0.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -0.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8079   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7809   -3.9431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 20 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  2  0  0  0  0
 28 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 15 37  1  0  0  0  0
 12 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3642

>  <JC_XSMILES>
COC1=CC=CC=C1C(=O)NC2CCN(CC(O)CN(CC3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4)C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2151

>  <W2 Pf proliferation inhibition EC50 uM>
0.1147

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019417476

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3643
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    0.1375   -6.1960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5770   -6.6086    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2915   -6.1961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0059   -6.6087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7204   -6.1962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4349   -6.6087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1494   -6.1963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1494   -5.3713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4350   -4.9587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7205   -5.3712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0060   -4.9587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2915   -5.3711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.9586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1374   -5.3710    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.1336    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -3.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -2.8960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -2.4835    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -1.6585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -1.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5873   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -0.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  3 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 23 24  1  0  0  0  0
 22 23  1  0  0  0  0
 21 26  1  0  0  0  0
 19 27  1  0  0  0  0
 25 26  1  0  0  0  0
 23 28  1  0  0  0  0
 25 27  1  0  0  0  0
 24 25  1  0  0  0  0
 19 28  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3643

>  <JC_XSMILES>
COC1=CC2=CC=CC=C2C=C1C(=O)NCCOC34CC5CC(CC(C5)C3)C4

>  <PF proliferation inhibition 3D7 EC50 uM>
3.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.145

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.021505376

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3646
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    4.1801    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -1.4223    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.4199   -1.9072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1650   -2.6919    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3400   -2.6919    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0850   -1.9072    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959    0.6402    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    1.8777    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3248    3.1152    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3248    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0393    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7538    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4682    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1827    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1827    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4682    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7538    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3646

>  <JC_XSMILES>
CC1=CC=CC(=C1)C2=CC(=CC(=C2)N3C=NN=N3)C(=O)NC4CCN(CC4)CC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.372

>  <W2 Pf proliferation inhibition EC50 uM>
0.57

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
50.09

>  <Powder data?>
Yes

>  <IFI value>
0.017094017

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3648
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
   -6.3587   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -3.5558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -5.2354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -5.2354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 18 27  1  0  0  0  0
 27 28  2  0  0  0  0
 24 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 36 38  1  0  0  0  0
 38 39  1  0  0  0  0
 38 40  2  0  0  0  0
  8 41  4  0  0  0  0
  4 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3648

>  <JC_XSMILES>
OC(=O)C1=CC=CC(NC(=O)C2=CC=C(C=C2)N3C(=O)C4=CC=C(C=C4C3=O)C(=O)NC5=CC=CC(=C5)C(O)=O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.136

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3653
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
   -0.0419    1.7168    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7564    1.3043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4709    1.7168    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4709    2.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1854    2.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9390    2.6187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4911    3.2318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0786    3.9463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2716    3.7748    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7564    0.4793    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0419    0.0668    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0419   -0.7582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6725   -1.1707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6725   -1.9957    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3870   -2.4082    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1015   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1015   -1.1707    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8159   -2.4082    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5304   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2449   -2.4082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9986   -2.0727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5506   -2.6857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1381   -3.4002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3311   -3.2287    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  2 10  1  0  0  0  0
 11 10  1  0  0  0  0
 11 12  2  0  0  0  0
 13 12  1  4  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3653

>  <JC_XSMILES>
S=C(NCC1=CC=CO1)NN=CC=NNC(=S)NCC2=CC=CO2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1214

>  <W2 Pf proliferation inhibition EC50 uM>
0.1133

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.116666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3656
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    4.7674    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2243   -1.1567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4515    0.1425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2585    0.3140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5134    1.0986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3204    1.2701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9614    1.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1544    1.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
  9 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3656

>  <JC_XSMILES>
CN1CCC2=C(C1)SC3=C2C(=O)NC(N3)C4=CC=C(O)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.755

>  <W2 Pf proliferation inhibition EC50 uM>
0.378

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
33.55

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3658
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    3.5439    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2584    1.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9728    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9728    2.3568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6873    2.7693    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6873    1.1193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4018    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1162    1.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1162    0.2943    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8307    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5452    1.1193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2989    1.4548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5538    2.2395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3608    2.4110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9128    1.7979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7198    1.9694    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   10.6579    1.0133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8509    0.8418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4384    0.1273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6933   -0.6573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1413   -1.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3962   -2.0551    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    8.3343   -1.0989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0794   -0.3143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6314    0.2988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  4  0  0  0  0
 19 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3658

>  <JC_XSMILES>
CCC(CO)NCC(O)CN1C2=CC=C(Br)C=C2C3=CC(Br)=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.526

>  <W2 Pf proliferation inhibition EC50 uM>
0.1255

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.16

>  <Powder data?>
Yes

>  <IFI value>
0.046511628

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3659
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -10.3125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.5724  -11.1375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -4.2868   -9.9000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 11 10  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
M  CHG  2  19   1  20  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3659

>  <JC_XSMILES>
NC1=CC=C(C=C1)C(=O)NN=CC2=CC=CC(=C2)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2976

>  <W2 Pf proliferation inhibition EC50 uM>
0.1117

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3660
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
    1.8414    1.8882    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.8414    1.0632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    0.6507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -0.1743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -0.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.1743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    0.6507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -1.4118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -2.1263    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.1263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.5388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.3638    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.1263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.5388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.1263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.3013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.8888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3660

>  <JC_XSMILES>
BrC1=CC=C(C=C1)C2NC2C(=O)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.989

>  <W2 Pf proliferation inhibition EC50 uM>
1.116

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3661
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    3.1465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9900    2.8916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8185    3.6986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1806    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5306    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.9979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6881    4.4829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9431    5.2675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7681    5.2675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0230    4.4829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 11 13  1  0  0  0  0
  5 14  4  0  0  0  0
 14 15  4  0  0  0  0
  2 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3661

>  <JC_XSMILES>
BrC1=CC2=C(N(CC2)C(=O)C3CC3)C(=C1)S(=O)(=O)N4CCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.929

>  <W2 Pf proliferation inhibition EC50 uM>
1.116

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3662
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
   -3.4712    0.7310    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.0940    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5560    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -5.2354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -5.2354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7648   -6.7749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9398   -6.7749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 22 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 30  1  0  0  0  0
 18 31  4  0  0  0  0
 14 31  4  0  0  0  0
 31 32  1  0  0  0  0
 11 32  1  0  0  0  0
 32 33  2  0  0  0  0
  9 34  4  0  0  0  0
  5 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3662

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(CN2C(=O)C3=CC=CC(N4CCC(CC4)C(=O)NC5CC5)=C3C2=O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.165

>  <W2 Pf proliferation inhibition EC50 uM>
1.114

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.042372881

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3664
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3058    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8933    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0863    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
  5 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 13 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 12 27  1  0  0  0  0
 27 28  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3664

>  <JC_XSMILES>
CC(=O)N(C1=CC=CC(F)=C1)C2=C(N3CCCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.406

>  <W2 Pf proliferation inhibition EC50 uM>
0.323

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
29.04

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3665
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3665

>  <JC_XSMILES>
CN1CCC(CC1)NCCC2=CC=C(Cl)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.909

>  <W2 Pf proliferation inhibition EC50 uM>
0.2097

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.89

>  <Powder data?>
Yes

>  <IFI value>
0.029411765

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3667
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    7.9531   -2.7990    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.1461   -2.6275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5941   -3.2406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7871   -3.0690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5322   -2.2844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4703   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0842   -1.6713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8912   -1.8429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 16 21  4  0  0  0  0
  5 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3667

>  <JC_XSMILES>
FC1=CC=C(CCNC2=NC=NC3=C2NC4=CC=CC=C34)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.257

>  <W2 Pf proliferation inhibition EC50 uM>
0.1329

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.98

>  <Powder data?>
Yes

>  <IFI value>
0.146341463

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3669
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6340   -8.6602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0292   -9.2213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2135   -9.0984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8010   -8.3839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1024   -7.6159    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8907   -7.3728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9543   -3.6401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -2.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -2.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6194   -3.6401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 18 24  1  0  0  0  0
  5 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 27 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3669

>  <JC_XSMILES>
COCCN(CC1=CC2=CC=C(F)C=C2N=C1N3CCCCCC3)C(=O)C4=COC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
5.2

>  <W2 Pf proliferation inhibition EC50 uM>
1.109

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.029411765

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3671
  Mrv1591402191617072D          

 23 23  0  0  0  0            999 V2000
   -2.1434    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414    4.2355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164    5.6645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020    1.9520    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    0.5230    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 14 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
M  CHG  2  21   1  22  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3671

>  <JC_XSMILES>
CC(C)(C)C(=O)NCCNC1=CC=C(C=C1C(F)(F)F)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.263

>  <W2 Pf proliferation inhibition EC50 uM>
1.108

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3674
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    1.4289    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.7661    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.9812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376    3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507    2.6841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353    2.9390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7484    2.3870    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6622    1.5665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4158    1.2309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9679    1.8440    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5554    2.5585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830    1.5291    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119    1.5291    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.9812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665    3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381    4.0431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796    2.6841    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.2911    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
  8 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
  7 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
  6 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 28  4  0  0  0  0
  3 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3674

>  <JC_XSMILES>
COC1=CC=C(C2N(CCCN3C=CN=C3)C(=O)C(O)=C2C(C)=O)C(OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.48

>  <W2 Pf proliferation inhibition EC50 uM>
1.106

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3677
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  7 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  5 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3677

>  <JC_XSMILES>
CC1=CC=C(NC2=NC(=CS2)C3=CC=CC=N3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.407

>  <W2 Pf proliferation inhibition EC50 uM>
0.368

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
33.34

>  <Powder data?>
Yes

>  <IFI value>
0.036231884

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3678
  Mrv1591402191617072D          

 45 48  0  0  0  0            999 V2000
    7.0583    1.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3439    0.9195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3439    0.0945    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6294   -0.3180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9149    0.0945    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6294   -1.1430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2968   -1.6279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0815   -1.3730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0419   -2.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5268   -3.0800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1913   -3.8337    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3473   -2.9938    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6829   -2.2401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5033   -2.1539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2169   -2.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7320   -3.0800    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9115   -2.9938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5759   -2.2401    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4266   -3.6612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7621   -4.4149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6061   -3.5750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1212   -4.2424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3761   -5.0270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7087   -5.5120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0412   -5.0270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2566   -5.2820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3565   -4.7299    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1411   -4.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7542   -4.4328    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3126   -5.7918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6995   -6.3439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8711   -7.1509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6557   -7.4058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2688   -6.8538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0534   -7.1087    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0973   -6.0468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2962   -4.2424    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8113   -3.5750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0092   -3.6612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4942   -2.9938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1586   -2.2401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6619   -2.1539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9974   -1.4002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1468   -2.8213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -1.6279    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 30 36  4  0  0  0  0
 25 37  4  0  0  0  0
 22 37  4  0  0  0  0
 37 38  1  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  1  0  0  0  0
 42 44  4  0  0  0  0
 38 44  4  0  0  0  0
 15 45  4  0  0  0  0
  6 45  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3678

>  <JC_XSMILES>
CCOC(=O)C1=C(C)C(C(=O)OCC)=C(NC(=O)C(C)SC2=NN=C(CNC(=O)C3=CC=CC(F)=C3)N2C4=CC=CC(C)=C4)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.103

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3681
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
   -0.6078   -0.4741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0597   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8443   -1.5291    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1953   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0203   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5052   -3.2361    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2752   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0598   -1.5291    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6729   -2.0811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5014   -2.8881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1145   -3.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8991   -3.1852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0706   -2.3782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4575   -1.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8553   -2.1233    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -5.4684   -2.6753    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -5.0268   -1.3163    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  2  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
M  CHG  2  16   1  17  -1
M  STY  1   1 DAT
M  SAL   1  1   5
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3681

>  <JC_XSMILES>
NN1C(=O)NC(O)=C1NC2=CC=CC(=C2)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.976

>  <W2 Pf proliferation inhibition EC50 uM>
0.1393

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>12.68

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3682
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3390   -2.3346    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8541   -1.6671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3682

>  <JC_XSMILES>
COC1=CC=C(C=C1)S(=O)(=O)N2CCC(CC2)C3=NN=C(O3)C4=CC=CC=C4OC

>  <PF proliferation inhibition 3D7 EC50 uM>
2.305

>  <W2 Pf proliferation inhibition EC50 uM>
1.098

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3683
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  2 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 12 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3683

>  <JC_XSMILES>
OC(CNC1CCCCC1)CN2C3=CC=CC=C3C4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.483

>  <W2 Pf proliferation inhibition EC50 uM>
0.1978

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.05

>  <Powder data?>
Yes

>  <IFI value>
0.021276596

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3685
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -3.6791   10.1277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501   10.1277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    8.8902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    8.8902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    8.4777    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2337    7.7632    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4087    9.1922    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    7.2402    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.0027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186    4.2803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637    3.4956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387    3.4956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837    4.2803    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3685

>  <JC_XSMILES>
CC1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C(=O)NCC3=CC=CO3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.894

>  <W2 Pf proliferation inhibition EC50 uM>
1.094

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3687
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6856   -2.8330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5021   -3.6373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164   -4.2823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -4.2823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3558   -3.6373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1722   -2.8330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 27 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3687

>  <JC_XSMILES>
CCOC(=O)N1CCC(CC1)N2C(=O)C3=CC=CC=C3N=C2SCC(=O)N4CCCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
7.34

>  <W2 Pf proliferation inhibition EC50 uM>
1.093

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3691
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.9500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.2868    5.7750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 10 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
 32 33  4  0  0  0  0
  8 33  4  0  0  0  0
M  CHG  2  23   1  24  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3691

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=CC(C(=O)OCC(=O)C3=CC=CC(=C3)[N+]([O-])=O)=C4C=C(C)C=CC4=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.089

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3693
  Mrv1591402191617072D          

 29 30  0  0  0  0            999 V2000
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  9 23  4  0  0  0  0
 23 24  4  0  0  0  0
  6 24  4  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3693

>  <JC_XSMILES>
CCC(C)(C)C1=CC=C(OCC(O)CNCC2=CC=CC=C2)C(=C1)C(C)(C)CC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.361

>  <W2 Pf proliferation inhibition EC50 uM>
0.1

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.2

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3697
  Mrv1591402191617072D          

 11 12  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
  2 11  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3697

>  <JC_XSMILES>
O=C1CSC2=CC=CC=C2N1

>  <PF proliferation inhibition 3D7 EC50 uM>
>10.65

>  <W2 Pf proliferation inhibition EC50 uM>
1.084

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.013888889

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3699
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2630    0.1043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6499    0.6563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8653    0.4014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  5 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   3
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3699

>  <JC_XSMILES>
SC1=NN=C(N1CCC2=CC=CC=C2)C3=CC=NC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>7.49

>  <W2 Pf proliferation inhibition EC50 uM>
1.08

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015151515

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3701
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    9.2646    2.4490    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.4488    2.5720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9344    1.9270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1187    2.0499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8172    2.8179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0015    2.9409    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4871    2.2958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6713    2.4188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3699    3.1868    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1569    1.7738    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5149    1.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1569    0.2872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3526    0.1036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7076    0.6180    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9230    0.3631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4380    1.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9230    1.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7076    1.4430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3526    1.9574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1690    2.7617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3807    3.0049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1971    3.8092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8019    4.3703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6183    5.1746    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5902    4.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7738    3.3228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3316    3.4629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1474    3.3399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 18 19  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3701

>  <JC_XSMILES>
ClC1=CC=C(OCC(=O)N2CCCN3C=CC=C3C2C4=CC=C(Cl)C=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.631

>  <W2 Pf proliferation inhibition EC50 uM>
0.108

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009708738

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3702
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   -9.9000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171  -12.7875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315  -14.8500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 20 28  4  0  0  0  0
 28 29  4  0  0  0  0
 17 29  4  0  0  0  0
  6 30  4  0  0  0  0
 30 31  4  0  0  0  0
  3 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3702

>  <JC_XSMILES>
COC1=CC=C(CN2CCC(CC2)C(=O)NC3=CC=C(OC4=CC=CN=C4)C=C3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.225

>  <W2 Pf proliferation inhibition EC50 uM>
0.64

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
59.38

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3703
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
  5 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 13 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 12 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3703

>  <JC_XSMILES>
CC(=O)N(C1=CC=C(I)C=C1)C2=C(N3CCOCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0737

>  <W2 Pf proliferation inhibition EC50 uM>
0.1081

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.04

>  <Powder data?>
Yes

>  <IFI value>
0.186666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3705
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -0.2934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
 15 19  4  0  0  0  0
  6 20  4  0  0  0  0
  2 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3705

>  <JC_XSMILES>
CC1=CC=CC(CCNC2=CC(C)=NC3=NC=NN23)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.841

>  <W2 Pf proliferation inhibition EC50 uM>
1.076

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3712
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   -5.6091   -1.7116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -2.9491    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -2.9491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7982   -6.7340    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0531   -7.5187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8781   -7.5187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1331   -6.7340    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    0.7634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235   -0.4741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4669   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4669    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.1814    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.9351    0.8403    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.4871    1.4534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0746    2.1679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2677    1.9964    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
  3 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 28 31  1  0  0  0  0
 31 32  2  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 31 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3712

>  <JC_XSMILES>
NC1=C(C=CC=C1C(=O)NC2=CC=C(C=C2)C3=NCCN3)C(=O)NC4=CC=C(C=C4)C5=NCCN5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2594

>  <W2 Pf proliferation inhibition EC50 uM>
0.1068

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.074074074

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3719
  Mrv1591402191617072D          

 13 15  0  0  0  0            999 V2000
    2.4230   -2.6863    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4068   -1.8614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7299   -1.3898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9693   -0.6003    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7942   -0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4519   -0.0860    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1288   -0.5577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9322   -0.3703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4962   -0.9724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2568   -1.7619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4534   -1.9493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8894   -1.3472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0645   -1.3635    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
  2 13  1  0  0  0  0
  5 13  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3719

>  <JC_XSMILES>
O=C1CSC2=NC3=CC=CC=C3N12

>  <PF proliferation inhibition 3D7 EC50 uM>
7.92

>  <W2 Pf proliferation inhibition EC50 uM>
1.063

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3721
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4215   -0.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2465   -0.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5014   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8340   -1.9524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4257   -5.3493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  1  0  0  0  0
 22 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3721

>  <JC_XSMILES>
CCOC(=O)N1CCC(CC1)NC(=O)C2=C(N3C=CC=C3)N(N=C2C)C4=CC=CC(C)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2801

>  <W2 Pf proliferation inhibition EC50 uM>
1.063

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3726
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -4.2664    1.6164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5520    1.2039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8375    1.6164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1230    1.2039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4086    1.6164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6941    1.2039    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0204    1.6164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0204    2.4414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7349    1.2039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8211    0.3834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6281    0.2118    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0406    0.9263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4885    1.5394    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6601    2.3464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4447    2.6013    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0470    2.8984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2623    2.6435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3508    3.1955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1792    4.0025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6054    4.2574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2185    3.7054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0031    3.9603    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8610    1.0126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4131    0.3995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1668    0.7350    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0805    1.5555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2735    1.7270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 12 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 23 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3726

>  <JC_XSMILES>
CCCCCNC(=O)C1CSC(N1C(=O)C2=CC=CC=C2Cl)C3=COC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.323

>  <W2 Pf proliferation inhibition EC50 uM>
1.057

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.009433962

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3728
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 21 27  4  0  0  0  0
 16 28  4  0  0  0  0
 11 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3728

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CNCCC3=CC=CC(F)=C3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.675

>  <W2 Pf proliferation inhibition EC50 uM>
0.1056

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019230769

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3729
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    2.3143   -4.9627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5073   -4.7911    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2523   -4.0065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4454   -3.8350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1904   -3.0504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7425   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4875   -1.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -0.4849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5812    2.1304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2486    2.6153    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0023    2.2798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1624    3.4358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945   -2.4454    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5494   -2.6088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8044   -3.3934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 12 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
  9 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
  6 34  4  0  0  0  0
 34 35  4  0  0  0  0
  3 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3729

>  <JC_XSMILES>
COC1=CC=C(CCN2C(=O)N(CCN(C)C)C(=O)C23CCN(CC3)CC4=CC=C(O)C=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2208

>  <W2 Pf proliferation inhibition EC50 uM>
0.828

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
78.47

>  <Powder data?>
Yes

>  <IFI value>
0.024096386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-373
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    0.9059   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7934   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809   -0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0309   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6954    0.2306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3084    0.7827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0229    0.3702    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8514   -0.4368    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4034   -1.0499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2104   -0.8784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7624   -1.4915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5075   -2.2761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7005   -2.4476    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4456   -3.2322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1485   -1.8345    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3415   -2.0060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2222    1.6032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1360    2.4236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0427    1.6894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4017    1.5169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -3.3809    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9059   -3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0809   -3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3316   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0809   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9059   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 11 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  4 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-373

>  <JC_XSMILES>
CCCN(CC(=O)NC1=CC(=NN1C2=CC=CC(C)=C2C)C(C)(C)C)C(=O)C3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.18

>  <W2 Pf proliferation inhibition EC50 uM>
>1.392

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.45

>  <Powder data?>
No

>  <IFI value>
0.009090909

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3730
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1331   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8781   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0531   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5682   -3.2361    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9038   -3.9898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4189   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7544   -5.4109    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5984   -4.5710    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7982   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0136   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4005   -2.0811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6159   -1.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 13 19  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3730

>  <JC_XSMILES>
CC1=CC=CC=C1OCC2=NN=C(SCC(O)=O)N2CC=C

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.052

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3733
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9462   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8192   -6.1117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2482   -5.2867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
  5 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 23 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3733

>  <JC_XSMILES>
CC1=CC=C(C=C1NC(=O)COC2=CC=C(C=C2)C(C)(C)C)C3=NC4=NC=CC=C4O3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.42

>  <W2 Pf proliferation inhibition EC50 uM>
1.051

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3734
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.5050    5.6355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3200    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3300    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 10 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3734

>  <JC_XSMILES>
CC(C)(C)NCC(O)CN1C2=CC=C(I)C=C2C3=CC(I)=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.608

>  <W2 Pf proliferation inhibition EC50 uM>
0.064

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.09

>  <Powder data?>
No

>  <IFI value>
0.040540541

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3736
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
  3 17  4  0  0  0  0
 11 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3736

>  <JC_XSMILES>
COC1=NC(NC(N)=N)=NC2=CC=C(C)C=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.88

>  <W2 Pf proliferation inhibition EC50 uM>
0.608

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
58

>  <Powder data?>
Yes

>  <IFI value>
0.060606061

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3737
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
  5 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 13 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 12 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3737

>  <JC_XSMILES>
CC(=O)N(C1=CC=C(Br)C=C1)C2=C(N3CCOCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2387

>  <W2 Pf proliferation inhibition EC50 uM>
0.2003

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.12

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3738
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    5.8293   -0.8867    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.0842   -1.6713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8912   -1.8429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1461   -2.6275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5941   -3.2406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7871   -3.0690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5322   -2.2844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4703   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3738

>  <JC_XSMILES>
FC1=CC=CC=C1CCNC2=NC=NC3=C2NC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1653

>  <W2 Pf proliferation inhibition EC50 uM>
0.1501

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.34

>  <Powder data?>
Yes

>  <IFI value>
0.125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3741
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 14 21  4  0  0  0  0
 21 22  1  0  0  0  0
 10 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 29 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  2  0  0  0  0
 24 35  4  0  0  0  0
  8 35  4  0  0  0  0
M  CHG  2  32   1  33  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3741

>  <JC_XSMILES>
CN1CCN(CC1)C2=NC(NN=CC3=CC(Br)=C(O)C=C3O)=NC(NC4=CC=C(C=C4)[N+]([O-])=O)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.321

>  <W2 Pf proliferation inhibition EC50 uM>
0.1044

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3742
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -1.1439   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0936   -3.8913    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.9186   -3.8913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3311   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9186   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0936   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -6.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1439   -6.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5564   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1439   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3311   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1561   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6410   -2.5093    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3861   -1.7247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9381   -1.1116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4256   -2.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1401   -2.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8546   -2.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5691   -2.3518    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5691   -1.5268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8546   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5691   -4.0018    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5691   -4.8268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1401   -4.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4256   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6410   -3.8442    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  3 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 27 28  1  0  0  0  0
 14 28  1  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3742

>  <JC_XSMILES>
CCN1C(\C=CC2=CC=CC=C12)=C\C3=[N+](CC)C4=CC(OC)=C(OC)C=C4S3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1356

>  <W2 Pf proliferation inhibition EC50 uM>
0.1044

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.230769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3743
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  8  7  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
  7 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
  6 19  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3743

>  <JC_XSMILES>
CCOC(=O)C1=C(N=NN(C)C)C2=CC=CC=C2N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1281

>  <W2 Pf proliferation inhibition EC50 uM>
0.376

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
36.06

>  <Powder data?>
Yes

>  <IFI value>
0.013605442

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3748
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    2.7512   -2.5366    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.0367   -2.9491    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.3222   -2.5366    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -4.2590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -5.0437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -5.0437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -4.2590    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -5.7111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4748   -6.4648    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -5.6249    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1661   -6.2923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9866   -6.2061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -5.4524    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8372   -4.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0168   -4.8712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1426   -5.3661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6276   -6.0336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4480   -5.9473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7836   -5.1937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2987   -4.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6342   -3.7726    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.4782   -4.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3748

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(O1)C(=O)N2CCN(CC2)C3=CC=CC(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
6.33

>  <W2 Pf proliferation inhibition EC50 uM>
1.037

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3749
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    6.3569    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9239    3.0381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4759    2.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0954    3.8451    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3810    4.2576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7679    3.7056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9609    3.8771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 16 28  1  0  0  0  0
 13 28  1  0  0  0  0
 14 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 11 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3749

>  <JC_XSMILES>
COC(=O)C1=CC=CC(=C1)C2=CC3=C(OC(CNC(=O)C4=C(C)ON=C4C)C3)C(Cl)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.881

>  <W2 Pf proliferation inhibition EC50 uM>
0.786

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
75.87

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-375
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
  6 11  4  0  0  0  0
  7 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-375

>  <JC_XSMILES>
BrC1=CC=CC2=C(C=CC=C12)C(=O)NCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.1

>  <W2 Pf proliferation inhibition EC50 uM>
1.471

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.039215686

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3750
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175   -4.4158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483   -3.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878   -3.3762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489   -2.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227   -3.3151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3847    2.9568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4122    3.1704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6257    2.3735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 13 18  4  0  0  0  0
 11 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 28 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3750

>  <JC_XSMILES>
CC(C)(C)CC(C)(C)NC1=C(N=C2C=CC=CN12)C3=CC=CC=C3OC(=O)C4CCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.729

>  <W2 Pf proliferation inhibition EC50 uM>
0.1035

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.038461538

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3751
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 11 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  2 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3751

>  <JC_XSMILES>
OC(CCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
4.65

>  <W2 Pf proliferation inhibition EC50 uM>
1.03

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015151515

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3757
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -5.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -6.2195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -5.4349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -6.8870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -6.8007    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9908   -7.6407    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4033   -8.3551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8513   -8.9682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0976   -8.6327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1838   -7.8122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
  2 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3757

>  <JC_XSMILES>
CC(CN1CCC(CC1)N2C=C(N=N2)C(=O)N3CCCC3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.409

>  <W2 Pf proliferation inhibition EC50 uM>
1.025

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.008849558

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3758
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -2.1730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -3.6020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
 12  9  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 15 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 13 30  1  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3758

>  <JC_XSMILES>
COC1=CC=C(C=C1)S(=O)(=O)N=C2C=C(NC3=CC=CC=C3)C(=O)C4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0933

>  <W2 Pf proliferation inhibition EC50 uM>
0.1225

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.96

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3761
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -0.1712    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6018    1.6373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4088    1.4657    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4303    0.8303    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.7733    2.4442    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
  9 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
  8 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3761

>  <JC_XSMILES>
OC1=CC=CC=C1C2=C(NC3=CC=CC(=C3)C(F)(F)F)N4C=CC=NC4=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
2.116

>  <W2 Pf proliferation inhibition EC50 uM>
1.02

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3762
  Mrv1591402191617072D          

 15 15  0  0  0  0            999 V2000
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3762

>  <JC_XSMILES>
CC1=CC=C(NC(=S)NCCO)C=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.81

>  <W2 Pf proliferation inhibition EC50 uM>
1.018

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3763
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -0.2601    5.1202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5469    4.9487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8018    4.1641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6088    3.9926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498    3.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498   -4.0609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 12 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  CHG  1  12   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3763

>  <JC_XSMILES>
CCC1=CC=C(C=C1)C(=O)C[N+]2=C3CCCN3C(=C2)C4=CC=C(C)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.764

>  <W2 Pf proliferation inhibition EC50 uM>
0.333

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
32.72

>  <Powder data?>
Yes

>  <IFI value>
0.095238095

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3769
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    0.8018   -4.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498   -4.0609    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6707    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9256    2.2518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6285    0.8541    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 11 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  9 24  4  0  0  0  0
 20 24  4  0  0  0  0
M  CHG  1  11   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3769

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C[N+](CC3=CC=CC=C3Cl)=C4CCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.578

>  <W2 Pf proliferation inhibition EC50 uM>
0.532

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
52.48

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-377
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -2.0061   -3.3087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2916   -3.7211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8791   -3.0066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7041   -4.4356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.1336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.9586    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1374   -5.3710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8519   -4.9585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8518   -4.1335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -3.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -2.8960    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -2.4835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5662   -2.8960    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -1.6585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -1.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5873   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -0.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 17 18  1  0  0  0  0
 16 21  1  0  0  0  0
 14 22  1  0  0  0  0
 20 21  1  0  0  0  0
 18 23  1  0  0  0  0
 20 22  1  0  0  0  0
 19 20  1  0  0  0  0
 14 23  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-377

>  <JC_XSMILES>
CC(C)(C)C1=NC=CC=C1OC(=O)C23CC4CC(CC(C4)C2)C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.349

>  <W2 Pf proliferation inhibition EC50 uM>
>1.468

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.031496063

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3770
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3744   -2.8920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1813   -2.7205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5938   -3.4350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0418   -4.0481    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 14 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  4  0  0  0  0
 27 28  4  0  0  0  0
 21 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3770

>  <JC_XSMILES>
CCCCOC1=CC=CC(=C1)C(=O)N(CC2=CC=CS2)C3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1243

>  <W2 Pf proliferation inhibition EC50 uM>
0.0621

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.13

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3771
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3771

>  <JC_XSMILES>
ClCC(=O)NC1=CC=C(C=C1)N2CCCCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.797

>  <W2 Pf proliferation inhibition EC50 uM>
0.417

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
41.19

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3772
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 13  2  1  4  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3772

>  <JC_XSMILES>
O=C(NNC(=O)C1=CC=CN=C1)C=CC2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.011

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3774
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -0.9021   -7.9725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5152   -7.4205    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3221   -7.5920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7346   -6.8775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1826   -6.2644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  2  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 18 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3774

>  <JC_XSMILES>
CN1CCCC1CCNCC2=CC(=CC=C2O)C3=CC=NC4=CC(Cl)=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.03136

>  <W2 Pf proliferation inhibition EC50 uM>
0.153

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.17

>  <Powder data?>
Yes

>  <IFI value>
0.05

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3777
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -0.0506   -4.1149    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.2933   -3.3650    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.1843   -2.6923    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1146   -3.2878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4585   -2.5379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2799   -2.4607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7574   -3.1335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5769   -3.2287    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1960   -2.6835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0334   -1.8747    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9778   -2.9471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5969   -2.4018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3787   -2.6654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5413   -3.4742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9222   -4.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1404   -3.7559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5213   -4.3011    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7395   -4.0376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0205   -4.4422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9253   -5.2616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4136   -3.8834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5922   -3.9606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  8 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
  7 21  4  0  0  0  0
 21 22  4  0  0  0  0
  4 22  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3777

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C2N3C(=O)C4=CC=CC=C4N=C3C(=O)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1485

>  <W2 Pf proliferation inhibition EC50 uM>
0.1005

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3779
  Mrv1591402191617072D          

 32 33  0  0  0  0            999 V2000
    6.3126   -2.3197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4930   -2.2251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1817   -2.7929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8539   -2.0358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3291   -3.6446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1487   -3.7392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4765   -4.4963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2960   -4.5909    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6239   -5.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1321   -6.0104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4600   -6.7675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9682   -7.4299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2960   -8.1870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1156   -8.2816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8043   -8.8494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9848   -8.7548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4930   -9.4172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6569   -7.9977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1487   -7.3353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8209   -6.5782    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3126   -5.9158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9848   -5.1587    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7878   -3.9285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4600   -3.1714    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.6073   -4.0231    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0991   -3.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9186   -3.4553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4104   -2.7929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2299   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.7216   -2.2251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5577   -3.6446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 13 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  2  0  0  0  0
  9 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3779

>  <JC_XSMILES>
CCN(CC)CCCN(CC1=CC2=C(C)C=C(C)C=C2NC1=O)C(=S)NCCCN(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
2.091

>  <W2 Pf proliferation inhibition EC50 uM>
1.005

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.025423729

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-378
  Mrv1591402191617072D          

 12 13  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
 11 12  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-378

>  <JC_XSMILES>
NC1=CC2=C(CCCC2)C=C1Br

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.031

>  <W2 Pf proliferation inhibition EC50 uM>
>1.467

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3782
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
   -0.9429   -5.4600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400   -4.0623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3782

>  <JC_XSMILES>
CN1CCC(=CC1)\C=C\C2=CNC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.483

>  <W2 Pf proliferation inhibition EC50 uM>
0.1004

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3784
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8020    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6090    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0215    0.2775    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.7381    0.6862    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5735   -0.3356    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4694   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  5 14  4  0  0  0  0
  9 14  4  0  0  0  0
  2 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 16 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3784

>  <JC_XSMILES>
O=C(COC1=CC=CC2=CC=CC=C12)NC3CCS(=O)(=O)C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.003

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3785
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
  6 15  1  0  0  0  0
  2 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3785

>  <JC_XSMILES>
OC(CNCC1COC2=CC=CC=C2O1)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.18

>  <W2 Pf proliferation inhibition EC50 uM>
1.002

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015037594

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3788
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
  7 14  4  0  0  0  0
  5 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
  4 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
  3 26  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3788

>  <JC_XSMILES>
CNC1=C(N(CC2=CC=C(Cl)C(Cl)=C2)C(C)=O)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.001231

>  <W2 Pf proliferation inhibition EC50 uM>
0.001258

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.1258

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-379
  Mrv1591402191617072D          

 42 47  0  0  0  0            999 V2000
   -2.8579   -3.3000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.7322   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  2  0  0  0  0
 26 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
 24 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 22 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  2  0  0  0  0
 14 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  2  0  0  0  0
 12 42  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-379

>  <JC_XSMILES>
BrC1=CC=C(C=C1)S(=O)(=O)NC2=CC3N(C4=CC=CC=C4)C5=CC(NS(=O)(=O)C6=CC=C(Br)C=C6)=CC=C5N=C3C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.929

>  <W2 Pf proliferation inhibition EC50 uM>
>1.467

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3791
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    2.8734    0.4022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0665    0.2306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9104   -0.4368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3584   -1.0499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7389    0.3702    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4534    0.7827    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7934   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809   -0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0309   -1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8514   -2.0382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0229   -2.8452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3084   -3.2577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6954   -2.7056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2222   -4.0782    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8897   -4.5631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6433   -4.2275    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8034   -5.3836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4709   -5.8685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3846   -6.6890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6309   -7.0245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9635   -6.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0497   -5.7191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3823   -5.2342    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9059   -3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0809   -3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3316   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0809   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9059   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  3  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
 11 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3791

>  <JC_XSMILES>
CC1=C(C(C)=NO1)S(=O)(=O)N(CC(O)CN2CCC(C2)NC(=O)C3=CC=CC=C3Cl)CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2556

>  <W2 Pf proliferation inhibition EC50 uM>
0.0997

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019417476

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3793
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
   -5.3367   -2.5327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9242   -1.8183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3367   -1.1038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9242   -0.3893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0992   -0.3893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6867   -1.1038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8617   -1.1038    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4492   -1.8183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8617   -2.5327    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6242   -1.8183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1393   -2.4857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3942   -3.2703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3547   -2.2308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3598   -2.6433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0743   -2.2308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0743   -1.4058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7193   -0.8914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5236   -1.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8816   -1.8183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5236   -2.5616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7193   -2.7452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3598   -0.9933    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3547   -1.4058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1393   -1.1508    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.3598   -3.4683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0273   -3.9532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7723   -4.7378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0527   -4.7378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3076   -3.9532    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0992   -1.8183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 15 21  1  0  0  0  0
 16 22  4  0  0  0  0
 22 23  4  0  0  0  0
 13 23  4  0  0  0  0
 23 24  4  0  0  0  0
 10 24  4  0  0  0  0
 14 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
  6 30  4  0  0  0  0
  2 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3793

>  <JC_XSMILES>
CC1=CC=CC(NC(=O)C2=C(N)C3=C(C4=C(CCCCC4)N=C3S2)C5=CC=CS5)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.995

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.037974684

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3794
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
   -2.8132   -5.4951    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -4.6701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -4.2576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -3.4326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -3.0201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6417   -2.2131    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4856   -2.8806    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -3.4326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -4.2576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  9 10  4  0  0  0  0
  2 10  4  0  0  0  0
  7 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 25 26  4  0  0  0  0
 17 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3794

>  <JC_XSMILES>
NC1=CC=C2N=C(SC2=C1)C3=CC=CC(=C3)C4=NC5=CC=C(N)C=C5S4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2833

>  <W2 Pf proliferation inhibition EC50 uM>
0.995

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.119402985

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3796
  Mrv1591402191617072D          

 15 17  0  0  0  0            999 V2000
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  2 15  4  0  0  0  0
 10 15  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   9
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3796

>  <JC_XSMILES>
O=C1C2=C(CCCC2)NC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.628

>  <W2 Pf proliferation inhibition EC50 uM>
0.991

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.021582734

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3798
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
  4 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  3  0  0  0  0
 16 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 19 26  4  0  0  0  0
  2 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3798

>  <JC_XSMILES>
NC1=NC(SCC(=O)C2=CC=C(Br)C=C2)=C(C#N)C(C3=CC=CC=C3)=C1C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.581

>  <W2 Pf proliferation inhibition EC50 uM>
0.56

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>56.56

>  <Powder data?>
Yes

>  <IFI value>
0.057471264

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3799
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5395    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4521   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6236   -1.8980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4082   -1.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0213   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8059   -1.9402    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8498   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0652   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8936   -4.0640    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4521   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6236   -1.8980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0652   -3.2570    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8498   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0213   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8059   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4190   -2.4922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2475   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4629   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8606   -3.8512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4737   -4.4032    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3086   -4.4643    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.4126   -3.2381    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 25 26  1  0  0  0  0
 15 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 36 38  1  0  0  0  0
 36 39  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3799

>  <JC_XSMILES>
CC(C)(C)OC(=O)N1CCC(CC1)C2=C(C=NN2C3=CC=C(F)C=C3F)C(=O)NC4=CC=CC(=C4)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.271

>  <W2 Pf proliferation inhibition EC50 uM>
0.99

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-380
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
   -2.6462   -0.6979    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-380

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C2=NC3=CC(Cl)=CN=C3N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.565

>  <W2 Pf proliferation inhibition EC50 uM>
>1.248

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.52

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3800
  Mrv1591402191617072D          

 17 20  0  0  0  0            999 V2000
    2.2269   -4.0163    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3157   -3.1961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7044   -2.6421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8836   -2.7258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4008   -2.0568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7387   -1.3042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5595   -1.2205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0423   -1.8895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8625   -1.9783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4773   -1.4283    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2612   -1.6857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9769   -1.2754    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5883   -1.8294    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2503   -2.5820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4301   -2.4932    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8153   -3.0433    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0315   -2.7859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  2 17  1  0  0  0  0
  9 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3800

>  <JC_XSMILES>
O=C1C2=CC=CC=C2C3=NC4=NN=NN4N=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2394

>  <W2 Pf proliferation inhibition EC50 uM>
0.0987

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.428571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3801
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  4  0  0  0  0
 13 19  4  0  0  0  0
  7 20  4  0  0  0  0
 20 21  4  0  0  0  0
  4 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3801

>  <JC_XSMILES>
CCOC1=CC=C(NC2=CC=NC3=CC(Cl)=CC=C23)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.956

>  <W2 Pf proliferation inhibition EC50 uM>
0.986

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.051724138

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3805
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -3.6610   -4.5769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4060   -3.7923    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5990   -3.6207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3441   -2.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400   -4.0623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0470   -4.2338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3020   -5.0184    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1089   -5.1900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
 14 19  4  0  0  0  0
  6 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3805

>  <JC_XSMILES>
COC1=CC=C(NC(=O)CN2N=CC3=CC=CC=C23)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.984

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.021276596

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3808
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -1.4795   -1.0908    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5126   -0.2665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7732    0.2009    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2622    0.3731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2791   -0.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0497   -0.8176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8029   -0.4811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0976    0.2895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7611    1.0427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9905    1.3374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2373    1.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7507    0.2525    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1946    0.1574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7555    0.9153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4266    1.6719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9173    2.3351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5884    3.0916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2313    3.1851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7221    2.5219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3931    1.7653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2430    0.1170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2761    0.9413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0066    1.3248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0397    2.1492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3423    2.5900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6119    2.2065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5788    1.3822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  4 11  1  0  0  0  0
 10 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  2 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3808

>  <JC_XSMILES>
O=C(NC1CC2CCCC(C1)N2CCC3=CC=CC=C3)NC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1557

>  <W2 Pf proliferation inhibition EC50 uM>
0.0982

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.013157895

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-381
  Mrv1591402191617072D          

 17 17  0  0  0  0            999 V2000
   -1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-381

>  <JC_XSMILES>
CCOC(=O)CCS(=O)(=O)C1=CC=C(Br)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2369

>  <W2 Pf proliferation inhibition EC50 uM>
>1.464

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.015384615

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3812
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
  8 16  4  0  0  0  0
 16 17  4  0  0  0  0
  5 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
  3 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3812

>  <JC_XSMILES>
CCC(SC1=NN=C(C2=CC=C(C)C=C2)C(=N1)C3=CC=C(C)C=C3)C(=O)NCCOC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.477

>  <W2 Pf proliferation inhibition EC50 uM>
0.753

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
76.95

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3814
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
  7 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3814

>  <JC_XSMILES>
CC(=O)NC1=NN(C(S1)C2=CC=C(Br)C=C2)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>7.54

>  <W2 Pf proliferation inhibition EC50 uM>
0.976

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.021276596

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3819
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    2.7159   -0.7525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4801   -1.0634    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.0910   -1.7909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7094   -0.2709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5339   -0.2441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0658    0.3866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8779    0.2414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4097    0.8721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1294    1.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6612    2.2787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2218    0.7268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5021   -0.0491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3142   -0.1943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5945   -0.9702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0627   -1.6009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2506   -1.4557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9703   -0.6798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1582   -0.5346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6264   -1.1653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8142   -1.0201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1629   -1.5264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  8 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
  7 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  5 20  4  0  0  0  0
 20 21  1  0  0  0  0
  2 21  1  0  0  0  0
M  CHG  1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3819

>  <JC_XSMILES>
C[N+]1(C)CC2=CC3=C(C=C)C=C4C=CC=CC4=C3C=C2C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.654

>  <W2 Pf proliferation inhibition EC50 uM>
0.974

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-382
  Mrv1591402191617072D          

 29 30  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 21 22  1  0  0  0  0
 11 23  4  0  0  0  0
 23 24  4  0  0  0  0
  8 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-382

>  <JC_XSMILES>
CC(C)CNC(=O)C1=CN=C(NCCCN2CCCCC2C)N=C1NCC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.344

>  <W2 Pf proliferation inhibition EC50 uM>
1.462

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019230769

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3820
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0418   -5.0269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5938   -5.6400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1813   -6.3545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3744   -6.1830    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  4  0  0  0  0
  8 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3820

>  <JC_XSMILES>
CCCCCCOC1=CC=C(NC(=O)C2=CC=CS2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.396

>  <W2 Pf proliferation inhibition EC50 uM>
0.972

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3821
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
   -6.2546   -2.1005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7697   -1.4330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9492   -1.5193    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4642   -0.8518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7998   -0.0981    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6438   -0.9380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0917   -0.3250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2633    0.4820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3381   -0.6605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6236   -0.2480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1946   -0.2480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1946    0.5770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5198   -0.6605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2343   -0.2480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2343    0.5770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9488    0.9895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6632    0.5770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6632   -0.2480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9488   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3777   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0922   -1.0730    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9652   -1.3750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.7902    0.0540    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4243   -1.4810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2313   -1.6525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8112   -2.0330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0266   -1.7781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4135   -2.3301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5850   -3.1371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0281   -3.6891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3696   -3.3920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9827   -2.8400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  9 25  4  0  0  0  0
 25 26  4  0  0  0  0
  6 26  4  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3821

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N(CCC(=O)NC2=CC=CC(=C2)C(F)(F)F)C(=C1)C3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.823

>  <W2 Pf proliferation inhibition EC50 uM>
0.327

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
33.67

>  <Powder data?>
Yes

>  <IFI value>
0.027027027

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3822
  Mrv1591402191617072D          

 25 28  0  0  1  0            999 V2000
    2.6521   -0.3564    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -1.0709    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8271   -1.7854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -0.6584    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -1.4834    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.6685   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -0.2459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5205   -0.3834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5205   -0.9334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830   -1.4834    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975   -0.2459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8119    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5264   -0.2459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -2.7209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -3.9584    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -3.9584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -2.7209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -2.7209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  2  0  0  0  0
  5  2  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
  5 16  1  6  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 16 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3822

>  <JC_XSMILES>
OS(=O)(=O)[C@H](C1CC2CCN1CC2C=C)C3=CC=NC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1522

>  <W2 Pf proliferation inhibition EC50 uM>
0.0971

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3824
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    1.4229   -2.4457    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4758    0.3498    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9237    0.9629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1787    1.7475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6267    2.3606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8816    3.1452    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3296    3.7583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5845    4.5429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3915    4.7144    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9435    4.1014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6886    3.3167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
  8 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  7 22  4  0  0  0  0
 22 23  4  0  0  0  0
  5 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3824

>  <JC_XSMILES>
BrC1=CC=C2NC3=C(NCCCN4CCOCC4)N=CN=C3C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.359

>  <W2 Pf proliferation inhibition EC50 uM>
0.957

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>98.66

>  <Powder data?>
Yes

>  <IFI value>
0.078431373

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3826
  Mrv1591402191617072D          

 28 31  0  0  1  0            999 V2000
    2.8579   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    8.8806   -3.2816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4043   -3.5566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  8  7  1  1  0  0  0
  9  8  1  1  0  0  0
  9 10  1  0  0  0  0
 11 10  1  1  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 16 15  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  1  0  0  0
 17 18  2  0  0  0  0
  8 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 19 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3826

>  <JC_XSMILES>
ClCCCC(=O)O[C@H]([C@H]1C[C@@H]2CCN1C[C@@H]2C=C)C3=CC=NC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.049

>  <W2 Pf proliferation inhibition EC50 uM>
0.0968

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3827
  Mrv1591402191617072D          

 38 43  0  0  0  0            999 V2000
    3.0094    1.3724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7239    1.7849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4384    1.3724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1529    1.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8673    1.3724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8673    0.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1529    0.1349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4384    0.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1529   -0.6901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8673   -1.1026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5818   -0.6901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5818    0.1349    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2963   -1.1026    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.0107   -0.6901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0107    0.1349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7252    0.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4397    0.1349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4397   -0.6901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7252   -1.1026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8673   -1.9276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5818   -2.3401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1529   -2.3401    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4384   -1.9276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6538   -2.1826    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.1688   -1.5151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3438   -1.5151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9313   -2.2296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2669   -2.9833    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6538   -3.5353    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9393   -3.1228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1547   -3.3777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4584   -2.8257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2869   -2.0187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4978   -1.7638    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1109   -2.3158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6538   -0.8477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3988   -0.0631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4384   -1.1026    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 10 20  2  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  4  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 27 35  4  0  0  0  0
 30 35  4  0  0  0  0
 25 36  4  0  0  0  0
 36 37  2  0  0  0  0
 36 38  4  0  0  0  0
  9 38  1  0  0  0  0
 23 38  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  29
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3827

>  <JC_XSMILES>
COC1=CC=CC(=C1)C2C(C(=O)NC3=CC=CC=C3)=C(C)N=c4sc(=CC5=CNC6=CC=CC=C56)c(=O)n24

>  <PF proliferation inhibition 3D7 EC50 uM>
2.474

>  <W2 Pf proliferation inhibition EC50 uM>
0.964

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3828
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  7 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  3 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3828

>  <JC_XSMILES>
COC1=CC2=CC(C(=O)NC3=CC=CC=C3)=C(N)N=C2C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.409

>  <W2 Pf proliferation inhibition EC50 uM>
0.964

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.044776119

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-383
  Mrv1591402191617072D          

 29 30  0  0  0  0            999 V2000
   -1.2253   -0.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4326   -0.2498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2345    0.5511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8290    1.1231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6308    1.9239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1618    2.1528    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3600    2.9536    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1526    3.1824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3508    3.9833    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7471    2.6104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5397    2.8392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1342    2.2672    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9360    1.4663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9453    0.4367    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5397   -0.1354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1526    0.2078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9268    2.4960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1250    3.2968    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.5213    1.9239    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3140    2.1528    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9084    1.5807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7011    1.8095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2955    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.0882    1.4663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0974    0.4367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5489    1.8095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7563    1.5807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5581    0.7799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  2  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 12 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10 27  4  0  0  0  0
 27 28  4  0  0  0  0
  6 28  4  0  0  0  0
 28 29  4  0  0  0  0
  3 29  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   7
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-383

>  <JC_XSMILES>
CCC1=CC=C2NC(=O)C(CN(CCN(C)C)C(=S)NCCCN(C)C)=CC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.761

>  <W2 Pf proliferation inhibition EC50 uM>
>1.461

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3830
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  4  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  8 16  4  0  0  0  0
  4 16  4  0  0  0  0
  1 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 17 25  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  25
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3830

>  <JC_XSMILES>
N(N=CC1=CC=CC(OC2=CC=CC=C2)=C1)C3=NC4=CC=CC=C4N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3015

>  <W2 Pf proliferation inhibition EC50 uM>
0.962

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3831
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5363    0.3736    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2508    0.7861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0044    0.4506    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0907   -0.3699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8443   -0.7055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9306   -1.5260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2631   -2.0109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5095   -1.6753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4232   -0.8548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6696   -0.5193    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0792    1.5931    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6313    2.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4382    2.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9903    2.6477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7353    3.4324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9284    3.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3763    2.9908    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2587    1.6793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1538    2.3938    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  4  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
  7 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 16 23  1  0  0  0  0
  5 23  1  0  0  0  0
 23 24  2  0  0  0  0
  3 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
  2 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3831

>  <JC_XSMILES>
CC1=C(\C=C2/SC(=NC3=CC=CC=C3F)N(C4CCCCC4)C2=O)C5=CC=CC=C5N1CC(N)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3007

>  <W2 Pf proliferation inhibition EC50 uM>
0.961

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3836
  Mrv1591402191617072D          

 14 15  0  0  0  0            999 V2000
    2.0367   -0.4741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5986   -3.9898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7479   -5.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9275   -5.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4425   -4.8297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6221   -4.9159    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.7781   -4.0760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
  6 12  4  0  0  0  0
  4 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3836

>  <JC_XSMILES>
NC1=NC(NC2=CC=CC(Cl)=C2)=NN1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.682

>  <W2 Pf proliferation inhibition EC50 uM>
0.958

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.010752688

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3837
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 12 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 20 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3837

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(=O)NC(C2=CC=CC=C2Cl)C3=CC(Cl)=C4C=CC=NC4=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.369

>  <W2 Pf proliferation inhibition EC50 uM>
0.833

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>87.04

>  <Powder data?>
Yes

>  <IFI value>
0.063492063

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3841
  Mrv1591402191617072D          

 31 32  0  0  0  0            999 V2000
   -3.4936   -1.1725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2236   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4135   -2.1079    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6835   -3.5111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8734   -1.4843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.7048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6033   -0.0811    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8734    0.6984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6835    0.8543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2236    0.2307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0337    0.3866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5738   -0.2370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3038   -1.0166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3839   -0.0811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6540    0.6984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4641    0.8543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1139    1.3221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3038    1.1662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7637    1.7898    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9535    1.6339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4135    2.2575    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7932   -0.2370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2531    0.3866    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5231   -1.0166    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2870   -1.1725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5570   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3672   -2.1079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6372   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4473   -3.0434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0971   -3.5111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 12 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 10 21  4  0  0  0  0
 21 22  2  0  0  0  0
  8 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3841

>  <JC_XSMILES>
CCN(CC)CCN(CC1=CC2=C(C)C=C(C)C=C2NC1=O)C(=S)NCCCN(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.854

>  <W2 Pf proliferation inhibition EC50 uM>
0.723

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>76.3

>  <Powder data?>
Yes

>  <IFI value>
0.020833333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3843
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3843

>  <JC_XSMILES>
COC1=CN=CC(=C1)C2=CN=CC(=N2)N3CCN(CC3)C4=CC=NC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0804

>  <W2 Pf proliferation inhibition EC50 uM>
0.0947

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3844
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7250   -0.1085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8965    0.6985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6811    0.9534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2942    0.4014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8526    1.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0242    2.5674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6596    1.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0457    1.9319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4257   -5.3493    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 12 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 26 32  4  0  0  0  0
  5 33  4  0  0  0  0
 33 34  4  0  0  0  0
  2 34  4  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3844

>  <JC_XSMILES>
CC1=CC=C(NC(=O)C2CSC(N2C(=O)C3=CC=C(C=C3)C(C)(C)C)C4=CC=CC(F)=C4)C=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.604

>  <W2 Pf proliferation inhibition EC50 uM>
0.008

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.848

>  <Powder data?>
No

>  <IFI value>
0.042553191

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3845
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
   -0.4558    4.0064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3688    4.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7588    4.7592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5834    4.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0180    4.0837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6280    3.3567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0626    2.6554    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8872    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3218    1.9800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9318    1.2530    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1072    1.2272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6726    1.9284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3664    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1910    0.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6256   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4502   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8849   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4949   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6703   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2357   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4111   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8784   -1.5066    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1147   -1.1947    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1752   -0.3719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5452    0.1607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9765   -0.1753    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8034    3.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4134    2.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 13 26  4  0  0  0  0
 21 26  4  0  0  0  0
  6 27  4  0  0  0  0
  2 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3845

>  <JC_XSMILES>
CC1=CC=CC(N2CCN(CC2)C3=NC4=CC=CC=C4C5=NN=C(C)N35)=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
4.4

>  <W2 Pf proliferation inhibition EC50 uM>
0.943

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3848
  Mrv1591402191617072D          

 40 45  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 14 23  4  0  0  0  0
 10 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
  9 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  1  0  0  0  0
 37 39  4  0  0  0  0
 39 40  4  0  0  0  0
 34 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3848

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2C(C(=O)NC3=CN=C4C=CC=CC4=C3)C5=CC=CC=C5C(=O)N2CC6=CC=C(F)C=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
2.17

>  <W2 Pf proliferation inhibition EC50 uM>
0.941

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011764706

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-385
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  2  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-385

>  <JC_XSMILES>
CCC1=CC=C(C=C1)C(C)=NNC2=NC(O)=CC(=N2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.783

>  <W2 Pf proliferation inhibition EC50 uM>
>1.459

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3850
  Mrv1591402191617072D          

 54 63  0  0  0  0            999 V2000
    9.7953    8.1781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2078    7.4636    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7953    6.7491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9703    6.7491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5578    6.0346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9703    5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5578    4.6057    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8933    3.8520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7003    3.6805    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7373    4.5195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1853    5.1326    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6689    3.0661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0814    3.7806    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9947    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7092    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4236    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4236    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7092    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9947    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7373   -1.2195    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5578   -1.3057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8933   -0.5520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9233    0.9826    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4383    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9233    2.3174    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7953    5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2078    6.0346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2078    4.6057    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   11.0328    4.6057    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   10.0362    3.7987    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 12 13  2  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 10 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 17 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 28 32  4  0  0  0  0
 32 33  4  0  0  0  0
 25 33  4  0  0  0  0
 24 34  2  0  0  0  0
 14 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 38 42  4  0  0  0  0
 42 43  4  0  0  0  0
 35 43  4  0  0  0  0
 14 44  1  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 48 49  4  0  0  0  0
 44 49  4  0  0  0  0
  6 50  4  0  0  0  0
 50 51  4  0  0  0  0
  3 51  4  0  0  0  0
 50 52  1  0  0  0  0
 52 53  1  0  0  0  0
 52 54  2  0  0  0  0
M  CHG  2  52   1  53  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3850

>  <JC_XSMILES>
COC1=CC=C(N2C(=O)C3C(C2=O)C4(C(=O)C3(C5=CC=CC=C5)C(C6=CC=C7OCOC7=C6)=C4C8=CC=C9OCOC9=C8)C%10=CC=CC=C%10)C(=C1)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.157

>  <W2 Pf proliferation inhibition EC50 uM>
0.938

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3854
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
  2 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3854

>  <JC_XSMILES>
CC1=CC=C2C=C(C)C(NC3=CC=C(Cl)C=C3)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.426

>  <W2 Pf proliferation inhibition EC50 uM>
0.57

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
60.96

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3855
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -2.3215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2673   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5223   -4.0623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3292   -4.2338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8813   -3.6207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6263   -2.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8194   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -3.9979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  4 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 21 27  4  0  0  0  0
 19 28  1  0  0  0  0
 15 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3855

>  <JC_XSMILES>
CN1N=C(C(=O)NCC2=CC=CC=C2)C3=C1CCN(CC4=CC=CC(O)=C4)C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>6.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.935

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012195122

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3857
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    1.4401   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1546   -5.5690    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1546   -4.7440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8690   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5835   -5.5690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2980   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0125   -5.5690    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7269   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7269   -6.8065    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4414   -7.2190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1559   -6.8065    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1559   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4414   -5.5690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6129   -4.7621    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4334   -4.6758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9183   -4.0084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7388   -4.0946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0744   -4.8483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5894   -5.5158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7690   -5.4295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3857

>  <JC_XSMILES>
CN(C)CCCNC1=NC=NC2=C1NC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2334

>  <W2 Pf proliferation inhibition EC50 uM>
0.934

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.06

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3858
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -1.4087   -7.1282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -7.1282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489    0.8152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227    1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    1.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175    3.0199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483    2.5100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 28 31  1  0  0  0  0
 22 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 35 37  4  0  0  0  0
 37 38  4  0  0  0  0
 32 38  4  0  0  0  0
 38 39  4  0  0  0  0
 21 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3858

>  <JC_XSMILES>
CCCCCC1=CC=C(C=C1)C(=O)OC2=CC=CC=C2C3=C(NC(C)(C)CC(C)(C)C)N4C=CC(C)=CC4=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.739

>  <W2 Pf proliferation inhibition EC50 uM>
0.0934

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.043478261

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3860
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
    3.5724    5.9411    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868    5.5286    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.0013    5.9411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.0536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.2286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9543    1.7437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    0.9590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743    0.9590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6194    1.7437    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3894    0.2916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5689    0.3778    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0840   -0.2896    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2635   -0.2034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7786   -0.8708    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0419   -0.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5268   -1.4520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3473   -1.3658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8322   -2.0332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6527   -1.9470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9882   -1.1933    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5033   -0.5259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6828   -0.6121    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3774   -0.0309    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1075    0.6365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2281    1.3902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2568    2.0576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0787    2.8113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4062    3.4788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2267    3.3925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5622    2.6389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0773    1.9714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9280    0.5503    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 15 13  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 20 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 29 37  4  0  0  0  0
 18 37  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3860

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)C2=CC=C(O2)C=NNC3=NC(NC4=CC=CC=C4)=NC(NC5=CC=CC=C5)=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.875

>  <W2 Pf proliferation inhibition EC50 uM>
0.933

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046511628

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3861
  Mrv1591402191617072D          

 33 38  0  0  0  0            999 V2000
    0.4567   -4.3270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7117   -3.5424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9666   -2.7578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4146   -2.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6695   -1.3601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4765   -1.1885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7314   -0.4039    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1794    0.2092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4343    0.9938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2413    1.1653    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7933    0.5522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5384   -0.2324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4963    1.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9442    2.5631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1992    3.3477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0061    3.5192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5582    2.9061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3032    2.1215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0285   -1.8016    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8535   -1.8016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4056   -1.1885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2125   -1.3601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4675   -2.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9154   -2.7578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1085   -2.5862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4410   -3.0712    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7736   -2.5862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3924   -2.3162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6473   -3.1008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4543   -3.2723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0063   -2.6593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7514   -1.8746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9444   -1.7031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  3  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
  6 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
 19 27  4  0  0  0  0
  4 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3861

>  <JC_XSMILES>
N#CC1=C(C=C(N2CCN(CC2)C3CCCCC3)N4C5=CC=CC=C5N=C14)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2335

>  <W2 Pf proliferation inhibition EC50 uM>
0.932

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3862
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
M  CHG  2  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3862

>  <JC_XSMILES>
CC1=CC(Cl)=CC=C1NC(=O)C2=CC=CC=C2[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.071

>  <W2 Pf proliferation inhibition EC50 uM>
0.93

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.008196721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3863
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 10 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
  9 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 30 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3863

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2C(C(=O)NC3=CC=CC(Cl)=C3)C4=CC=CC=C4C(=O)N2C5CCCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.552

>  <W2 Pf proliferation inhibition EC50 uM>
0.93

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3864
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
   -0.0938   -7.4708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6459   -6.8577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3909   -6.0731    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429   -5.4600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -5.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 16 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 15 33  4  0  0  0  0
 27 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3864

>  <JC_XSMILES>
CCN1CCC(CC1)N2CCC(CC2)N3C(CC4=CC=CC=C4OC)=NC5=CC(F)=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
0.413

>  <W2 Pf proliferation inhibition EC50 uM>
0.35

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
37.69

>  <Powder data?>
Yes

>  <IFI value>
0.016949153

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3865
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -1.8212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
 13 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  4  0  0  0  0
  7 21  4  0  0  0  0
 21 22  1  0  0  0  0
  5 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3865

>  <JC_XSMILES>
CC1=CC=C(CN2C(C)=C3C=NN(CC(O)=O)C(=O)C3=C2C)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.01

>  <W2 Pf proliferation inhibition EC50 uM>
0.928

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3866
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.5837   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  3  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  2 10  4  0  0  0  0
 11 10  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  22
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3866

>  <JC_XSMILES>
OC1=C(CC=C)C=CC=C1C=NNC2=NC3=CC=CC=C3N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.657

>  <W2 Pf proliferation inhibition EC50 uM>
0.928

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3867
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    3.9855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    4.8105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  4  0  0  0  0
 19 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3867

>  <JC_XSMILES>
OC(CN1CCOCC1)CN2C3=CC=C(Br)C=C3C4=CC(Br)=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.991

>  <W2 Pf proliferation inhibition EC50 uM>
0.44

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
47.45

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3869
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    5.7158    4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  2  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 10 24  4  0  0  0  0
 19 24  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
 25 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3869

>  <JC_XSMILES>
ClC1=CC=C(NC(=O)CN2C3=CC=CC=C3C(=O)C4=CC=CC=C24)C(=C1)C(=O)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.817

>  <W2 Pf proliferation inhibition EC50 uM>
0.925

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.060240964

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3871
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
    6.9246    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    4.8229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    4.8229    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -0.1006    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -0.5422    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -1.9399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -2.7246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -2.8961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -3.6807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -2.2830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -1.4984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 18 19  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 20 26  4  0  0  0  0
 15 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 35 36  4  0  0  0  0
 30 36  4  0  0  0  0
  6 37  4  0  0  0  0
 37 38  4  0  0  0  0
  3 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3871

>  <JC_XSMILES>
COC1=CC=C(NC(=O)C2=C(C)NC3=C(C=NN3C2C4=CC=CC(Cl)=C4)C(=O)NC5=CC=C(C)C=C5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.508

>  <W2 Pf proliferation inhibition EC50 uM>
0.924

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3873
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435    1.9817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0645    1.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  2  0  0  0  0
  8 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 13 19  1  0  0  0  0
 14 20  4  0  0  0  0
  6 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3873

>  <JC_XSMILES>
CCSC1=NC2=C(C(=O)N1CC)C3=C(CN(C)CC3)S2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.409

>  <W2 Pf proliferation inhibition EC50 uM>
0.923

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.08

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3875
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  9 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 21 31  4  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3875

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(NC(=O)COC2=CC=CC=C2)C3=CC(Cl)=C4C=CC=NC4=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
3.57

>  <W2 Pf proliferation inhibition EC50 uM>
0.918

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3877
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    4.8136   -5.3306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5281   -4.9181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2426   -5.3306    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9570   -4.9181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9570   -4.0931    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6715   -5.3306    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3860   -4.9181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1005   -5.3306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8149   -4.9181    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.5294   -5.3306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2831   -4.9950    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.8351   -5.6081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6556   -5.5219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9911   -4.7682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.8116   -4.6820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2966   -5.3494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9610   -6.1031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1405   -6.1893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4226   -6.3226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6156   -6.1511    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0025   -6.7031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2179   -6.4482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7582   -7.0763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5786   -7.1625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9142   -7.9162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4293   -8.5836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6088   -8.4974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2732   -7.7437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 12 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 19 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3877

>  <JC_XSMILES>
CCNC(=O)NCCSC1=NC(C2=CC=CC=C2)=C(N1CC)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.633

>  <W2 Pf proliferation inhibition EC50 uM>
0.917

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-388
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
   10.5406    3.9747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7242    3.1703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5125    2.9272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6961    2.1229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0914    1.5617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3030    1.8049    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.6982    1.2437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9099    1.4869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3051    0.9258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5168    1.1689    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9120    0.6078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0956   -0.1965    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1237    0.8510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9401    1.6553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1517    1.8985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5470    1.3373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7305    0.5330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5189    0.2898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2162   -0.1120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5741   -0.8553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1094   -1.5370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2867   -1.4753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8219   -2.1569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9993   -2.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1799   -2.9002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0026   -2.9619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4673   -2.2803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2900   -2.3419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3912   -0.1120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0332   -0.8553    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8768    0.5330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0884    0.2898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4837    0.8510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6673    1.6553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4556    1.8985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0604    1.3373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8037    1.6953    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4291    2.4304    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1782    2.4304    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.1194    2.6092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 27 28  1  0  0  0  0
 19 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 36 37  1  0  0  0  0
 16 37  1  0  0  0  0
 37 38  2  0  0  0  0
 37 39  2  0  0  0  0
  6 40  1  0  0  0  0
  2 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-388

>  <JC_XSMILES>
CC1CCCN(CCCNC(=O)C2=CC=C3C(=C2)N(CC4=CC(C)=CC=C4C)C(=O)C5=CC=CC=C5S3(=O)=O)C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.073

>  <W2 Pf proliferation inhibition EC50 uM>
1.75

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.04

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3881
  Mrv1591402191617072D          

 38 43  0  0  1  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8953   -2.6447    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1774   -3.4200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6471   -4.0520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8347   -3.9087    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5525   -3.1335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0828   -2.5015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3044   -4.5407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5865   -5.3159    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0562   -5.9479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7562   -5.8047    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0384   -5.0294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5081   -4.3974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8509   -4.8862    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4443   -5.4593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1727   -5.0719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0295   -4.2595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2125   -4.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3384   -6.7232    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1315   -6.9506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1602   -7.7751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3850   -8.0572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1229   -7.4071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  9  8  1  0  0  0  0
  9 10  1  1  0  0  0
  9 11  1  6  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 24 28  1  0  0  0  0
 20 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 29 33  1  0  0  0  0
  9 34  1  0  0  0  0
  5 34  1  0  0  0  0
  6 35  4  0  0  0  0
 35 36  1  0  0  0  0
 35 37  4  0  0  0  0
  2 37  4  0  0  0  0
 37 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3881

>  <JC_XSMILES>
CC1=C(C)C2=C(CC[C@](C)(CN3CCN(CC3)C4=CC(=NC(=N4)N5CCCC5)N6CCCC6)O2)C(C)=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1752

>  <W2 Pf proliferation inhibition EC50 uM>
0.384

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
42

>  <Powder data?>
Yes

>  <IFI value>
0.051948052

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3882
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -2.0367   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -0.4741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    0.7634    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3693   -4.2590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6242   -5.0437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4492   -5.0437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7041   -4.2590    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  5 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  1 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3882

>  <JC_XSMILES>
C(NC1=CC(=NC(=N1)C2=CC=CC=N2)C3=CC=CC=N3)C4=CC=CO4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1824

>  <W2 Pf proliferation inhibition EC50 uM>
0.0914

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3884
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
  5 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 14 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 13 29  1  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3884

>  <JC_XSMILES>
CC(=O)N(C1=CC(C)=CC(C)=C1)C2=C(N3CCOCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0401

>  <W2 Pf proliferation inhibition EC50 uM>
0.0633

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.94

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3885
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  3  9  4  0  0  0  0
  9 10  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 16 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 12 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3885

>  <JC_XSMILES>
COC1=CC(=CC(Br)=C1O)C2C(=C(C)NC3=C2C(=O)CC(C3)C4=CC=CC=C4)C(=O)OCC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.85

>  <W2 Pf proliferation inhibition EC50 uM>
0.911

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046511628

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3886
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2890   -4.3257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8671   -5.1657    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3822   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7177   -6.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2328   -7.2542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5877   -7.1680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9232   -6.4143    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4383   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  3  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3886

>  <JC_XSMILES>
CCC1=CC=C(O)C(=C1)C2=NNC(=C2)C(=O)NC3=CC=CN=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.742

>  <W2 Pf proliferation inhibition EC50 uM>
0.91

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.066666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3887
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    4.8505    1.3508    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.0255    1.3508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6130    2.0653    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0255    2.7797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6130    3.4942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0255    4.2087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8505    4.2087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2630    3.4942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8505    2.7797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6130    0.6363    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7880    0.6363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4300    1.3796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6257    1.5632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9807    1.0488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9807    0.2238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6257   -0.2905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4300   -0.1070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3940    0.6363    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5690    0.6363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1565   -0.0781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5690   -0.7926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1565   -1.5071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6685   -1.5071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0810   -0.7926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6685   -0.0781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3887

>  <JC_XSMILES>
S=C(NC1CCCCC1)NC2CC3CCC(C2)N3CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.973

>  <W2 Pf proliferation inhibition EC50 uM>
0.468

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
51.45

>  <Powder data?>
Yes

>  <IFI value>
0.012658228

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3888
  Mrv1591402191617072D          

 22 26  0  0  0  0            999 V2000
    3.6774    0.1825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4379    0.9720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6131    0.9883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3427    0.2088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0005   -0.2892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5179    0.2251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9539   -0.3770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1933   -1.1665    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6293   -1.7686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7849   -2.5788    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0624   -2.9771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1250   -3.7805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9145   -4.0200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5166   -3.4560    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3292   -2.6525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5397   -2.4131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1893   -1.6662    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1505   -0.1896    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0890    0.5999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4750    1.2020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2785    1.0146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9554    1.4863    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
  7 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  6 21  4  0  0  0  0
 21 22  4  0  0  0  0
  3 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3888

>  <JC_XSMILES>
C1CC2=C(C1)C3=C(SC4=NC5=CC=CC=C5N4)N=CN=C3S2

>  <PF proliferation inhibition 3D7 EC50 uM>
6.84

>  <W2 Pf proliferation inhibition EC50 uM>
0.909

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015151515

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3890
  Mrv1591402191617072D          

 30 31  0  0  0  0            999 V2000
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.1486    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.8631    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   23.5775    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   23.5775    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   24.2920    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   25.0065    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   25.0065    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   25.7210    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   25.7210   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   26.4354   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   25.0065   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   24.2920   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   24.2920    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 20 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3890

>  <JC_XSMILES>
CCCCCCCCCCCC(=O)N(C)CCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2232

>  <W2 Pf proliferation inhibition EC50 uM>
0.02732

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.006

>  <Powder data?>
No

>  <IFI value>
0.028037383

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3893
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0727    2.3174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5577    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0727    0.9826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  2  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 13 26  4  0  0  0  0
 21 26  4  0  0  0  0
  6 27  4  0  0  0  0
  2 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3893

>  <JC_XSMILES>
CC1=CC=CC(NC(=O)CCCN2C(=O)C3=CC=CN3C4=CC=CC=C24)=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.778

>  <W2 Pf proliferation inhibition EC50 uM>
0.906

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034482759

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3895
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    5.6165   -1.2553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8095   -1.4268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8706   -0.2617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6444   -1.3657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2243   -1.1567    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6723   -1.7698    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9273   -2.5545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3752   -3.1676    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6302   -3.9522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4371   -4.1237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0781   -4.5653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7288   -4.3937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9838   -3.6091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4317   -2.9960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6867   -2.2114    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 15 14  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  1  0  0  0  0
 13 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 12 28  4  0  0  0  0
 28 29  4  0  0  0  0
  9 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3895

>  <JC_XSMILES>
CCC(C)(C)C1CCC2=C(C1)C3=C(NN=CC4=C(Cl)C=CC=C4Cl)N=CN=C3S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.733

>  <W2 Pf proliferation inhibition EC50 uM>
0.904

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.044117647

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3896
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 14 27  4  0  0  0  0
  9 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3896

>  <JC_XSMILES>
COC1=CC=CC(=N1)C2=CC=C(O)C(CN(C)CC(O)C3=CC=CC=C3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.246

>  <W2 Pf proliferation inhibition EC50 uM>
0.0904

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.025641026

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3898
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3273    1.9856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8794    1.3725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4669    0.6580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6599    0.8295    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 13 12  1  4  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
  7 26  4  0  0  0  0
  3 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3898

>  <JC_XSMILES>
COC1=CC=CC(OCC(=O)NN=C(C)CC(=O)NCC2=CC=CO2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.901

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-390
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 16 23  4  0  0  0  0
  5 24  4  0  0  0  0
 24 25  4  0  0  0  0
  2 25  4  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-390

>  <JC_XSMILES>
CC1=CC=C(NC(=O)CCCCC(=O)NC2=CC=C(C)C(Br)=C2)C=C1Br

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.155

>  <W2 Pf proliferation inhibition EC50 uM>
>1.451

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3902
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    5.6982    1.3419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8742    1.3830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9768    0.5644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0578    2.1873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4530    2.7485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6366    3.5528    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6647    2.5053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4811    1.7010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0859    1.1398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7378    1.3430    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9945    1.7010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3897    1.1398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6014    1.3830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4178    2.1873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0226    2.7485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8109    2.5053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3253    3.1503    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1503    3.1503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5083    3.8936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1173    4.6201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6874    5.2164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4307    4.8584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3200    4.0409    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1572    5.2494    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.8590    4.8157    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.1819    6.0740    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9673    3.8936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4321    4.5752    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1447    3.9553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7867    4.6986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0360    4.7602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3939    5.5035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0708    6.1851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8935    6.1235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2514    5.3802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  2  9  1  0  0  0  0
  8 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
  7 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 17 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  CHG  2  24   1  25  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3902

>  <JC_XSMILES>
CC1(C)CC(=O)C2=C(C1)NC3=CC=CC=C3N(C2C4=CC=C(S4)[N+]([O-])=O)C(=O)CC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.0898

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.011904762

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3904
  Mrv1591402191617072D          

 29 30  0  0  0  0            999 V2000
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 17 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
 13 24  4  0  0  0  0
 11 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3904

>  <JC_XSMILES>
CCOC(=O)C1=CN(C)C=C(C1C2=CC(Br)=C(OCC)C(OC)=C2)C(=O)OCC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.913

>  <W2 Pf proliferation inhibition EC50 uM>
0.897

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034482759

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3907
  Mrv1591402191617072D          

 15 15  0  0  0  0            999 V2000
    0.0000    3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 14  4  0  0  0  0
 14 15  4  0  0  0  0
  5 15  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3907

>  <JC_XSMILES>
FC(F)OC1=CC=C(NC(=O)CCl)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.317

>  <W2 Pf proliferation inhibition EC50 uM>
0.1619

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.1

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3908
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
   -3.9284   -3.5558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -4.2703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409   -7.1282    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0054   -7.8819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6185   -8.4339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3329   -8.0214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1614   -7.2144    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
  2 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
 25 30  4  0  0  0  0
 22 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3908

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)N2C=CC=N2)C3CCN(CC3)CC4=NC5=C(CCCC5)S4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.354

>  <W2 Pf proliferation inhibition EC50 uM>
0.894

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3909
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  5 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  3 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   4
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3909

>  <JC_XSMILES>
NNC1=NC(NCC2=CC=CC=C2)=NC(=N1)N3CCOCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0718

>  <W2 Pf proliferation inhibition EC50 uM>
0.0894

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.030769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3911
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    5.7454   -4.3974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -4.3974    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -2.9684    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -2.9684    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2079   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  3  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  7 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 12 26  1  0  0  0  0
 17 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3911

>  <JC_XSMILES>
COC1=CC(Br)=C(C=C1OC)C2CC(=O)NC3=CC=C4C=CC=CC4=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.386

>  <W2 Pf proliferation inhibition EC50 uM>
0.3068

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
34.37

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3914
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  3 11  4  0  0  0  0
 12 11  1  4  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  4  0  0  0  0
 14 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3914

>  <JC_XSMILES>
CCN1C2=CC=CC=C2N=C1N=NC3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0975

>  <W2 Pf proliferation inhibition EC50 uM>
0.1152

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.96

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3919
  Mrv1591402191617072D          

 19 22  0  0  0  0            999 V2000
    4.8048   -1.5924    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5552   -0.8061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1115   -0.1968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9172   -0.3739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4735    0.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2239    1.0218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4181    1.1989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8619    0.5896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0561    0.7666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8066    1.5530    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4999    0.1573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7495   -0.6290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1932   -1.2383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3875   -1.0613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1379   -0.2749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3865    0.0658    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4784    0.8856    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2865    1.0516    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6941    0.3344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
  2 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
 15 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3919

>  <JC_XSMILES>
O=C1C2=CC=CC=C2C(=O)C3=C1C=CC4=NON=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1207

>  <W2 Pf proliferation inhibition EC50 uM>
0.0886

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.308219178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3921
  Mrv1591402191617072D          

 14 15  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  2  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3921

>  <JC_XSMILES>
CC1=C(Br)C(=O)C2=CC(C)=CC=C2N1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.244

>  <W2 Pf proliferation inhibition EC50 uM>
0.884

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.028985507

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3922
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -1.2822   -1.8800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9962    3.5889    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  3  0  0  0  0
  7 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 18 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
  6 33  4  0  0  0  0
 26 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3922

>  <JC_XSMILES>
CCOC(=O)C1=C(CN2CCN(CC2)CC#N)N(CC3=CC=CC=C3)C4=CC(Br)=C(O)C=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
1.179

>  <W2 Pf proliferation inhibition EC50 uM>
0.884

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3923
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4793   -0.5874    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6543    0.8415    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    0.5396    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.3646    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    3.0146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    3.8396    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  2  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
  6 11  4  0  0  0  0
  8 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3923

>  <JC_XSMILES>
CN1C(=O)OC2=CC(=CC=C12)S(=O)(=O)N3CCN(CC3)C4=CC(Cl)=CC=C4C

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.882

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3924
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  3  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  4 17  1  0  0  0  0
 12 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3924

>  <JC_XSMILES>
C#CCN1C2=CC=CC=C2SC3=CC=CN=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0504

>  <W2 Pf proliferation inhibition EC50 uM>
0.321

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
36.42

>  <Powder data?>
Yes

>  <IFI value>
0.061728395

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3927
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    2.0701   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2997    0.6934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1067    0.8650    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.5192    0.1505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9671   -0.4626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  2  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3927

>  <JC_XSMILES>
CC(CC1=CSC=C1)NC2=NC3=NON=C3N=C2N(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.81

>  <W2 Pf proliferation inhibition EC50 uM>
0.881

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3930
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 10 17  4  0  0  0  0
  5 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
  4 26  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3930

>  <JC_XSMILES>
CN(C)C1=C(N(C(C)=O)C2=CC=C(Cl)C(Cl)=C2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.082

>  <W2 Pf proliferation inhibition EC50 uM>
0.0734

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.35

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3933
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    0.9606    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2159   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2159   -4.2703    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4985   -3.8578    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9304   -4.6828    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1966   -4.9848    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0216   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4341   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0216   -6.4137    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1966   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2159   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
  6 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3933

>  <JC_XSMILES>
COC(=O)C1=C(NC(=O)C2=CC=C(C=C2)S(=O)(=O)N3CCOCC3)SC4=C1CCN(C4)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
8.66

>  <W2 Pf proliferation inhibition EC50 uM>
0.878

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3936
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    4.7505    0.3510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0360   -0.0615    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0360   -0.8865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7505   -1.2990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7505   -2.1240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0360   -2.5365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0360   -3.3615    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3215   -3.7740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3215   -2.1240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3215   -1.2990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6071   -2.5365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6071   -3.3615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8926   -3.7740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1781   -3.3615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4637   -3.7740    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1781   -2.5365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4637   -2.1240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4637   -1.2990    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2796   -0.9410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4632   -0.1367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0512    0.5083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8762    0.5083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3905   -0.1367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2070   -0.9410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8926   -2.1240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 18 24  1  0  0  0  0
 16 25  4  0  0  0  0
 11 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3936

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CN3CCCCCC3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.57

>  <W2 Pf proliferation inhibition EC50 uM>
0.0876

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019230769

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3937
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    4.4703   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5322   -2.2844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0842   -1.6713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8912   -1.8429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1461   -2.6275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5941   -3.2406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7871   -3.0690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  1  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3937

>  <JC_XSMILES>
C(CC1=CC=CC=C1)NC2=NC=NC3=C2NC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.167

>  <W2 Pf proliferation inhibition EC50 uM>
0.1365

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.59

>  <Powder data?>
Yes

>  <IFI value>
0.219512195

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3938
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.4795   -1.0908    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5126   -0.2665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7732    0.2009    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2622    0.3731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2791   -0.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0497   -0.8176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8029   -0.4811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0976    0.2895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7611    1.0427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9905    1.3374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2373    1.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7507    0.2525    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1946    0.1574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7555    0.9153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4266    1.6719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9173    2.3351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5884    3.0916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2313    3.1851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7221    2.5219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3931    1.7653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2430    0.1170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2761    0.9413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0066    1.3248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0397    2.1492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3423    2.5900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6119    2.2065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5788    1.3822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3754    3.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4086    4.2387    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  4 11  1  0  0  0  0
 10 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  2 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 25 28  1  0  0  0  0
 28 29  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3938

>  <JC_XSMILES>
O=C(NC1CC2CCCC(C1)N2CCC3=CC=CC=C3)NC4=CC=C(C=C4)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.362

>  <W2 Pf proliferation inhibition EC50 uM>
0.425

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.55

>  <Powder data?>
Yes

>  <IFI value>
0.037974684

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3939
  Mrv1591402191617072D          

 41 46  0  0  0  0            999 V2000
    1.3363   -4.7113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3073   -3.8868    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.5788   -3.4996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1207   -3.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8492   -3.5498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8782   -2.7253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1787   -2.2880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2076   -1.4635    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4919   -1.0261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2204   -1.4133    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4629   -0.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1725    0.3212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0841    1.2649    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6349    1.1456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4025    1.4739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8583    0.7254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0550    0.3597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8811    0.4621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4594   -0.1263    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9973    1.2836    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7337    1.6554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4239    1.2035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1604    1.5753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8506    1.1234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8044    0.2997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4946   -0.1522    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0679   -0.0721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3777    0.3798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2637    1.6800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1776    2.5005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8451    2.9853    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4239    2.8361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3378    3.6566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4158    3.9923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5019    4.8128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1656    5.2976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9193    4.9619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5868    5.4468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0054    4.1414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7590    3.8058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5498   -2.6751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
 20 29  1  0  0  0  0
 14 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  1  0  0  0  0
 33 39  1  0  0  0  0
 39 40  1  0  0  0  0
  7 41  4  0  0  0  0
  3 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3939

>  <JC_XSMILES>
CSC1=CC=CC(NC(=O)C2C3OC4(C=C3)C2C(=O)N(CC5=CC=C(F)C=C5)C4C(=O)NC6CCCC(C)C6C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.433

>  <W2 Pf proliferation inhibition EC50 uM>
0.875

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-394
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    4.1349    0.9412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8494    1.3537    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5638    0.9412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2783    1.3537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9928    0.9412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7072    1.3537    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.4217    0.9412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4217    0.1162    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1362    1.3537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2224    2.1742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6093    2.7262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0294    2.3457    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4419    1.6313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1956    1.2957    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.1093    0.4752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3024    0.3037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9668   -0.4500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8899    1.0182    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
  9 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-394

>  <JC_XSMILES>
COCCCNC(=O)C1=C(C)N=C2SC=C(C)N12

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.079

>  <W2 Pf proliferation inhibition EC50 uM>
>1.448

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3940
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -0.2601    5.1202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5469    4.9487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8018    4.1641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6088    3.9926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498    3.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498   -4.0609    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8018   -4.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 12 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
 26 27  4  0  0  0  0
 20 27  4  0  0  0  0
M  CHG  1  12   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3940

>  <JC_XSMILES>
CCC1=CC=C(C=C1)C(=O)C[N+]2=C3CCCN3C(=C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.677

>  <W2 Pf proliferation inhibition EC50 uM>
0.857

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>97.99

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3941
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    1.4401   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1546   -5.5690    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1546   -4.7440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8690   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5835   -5.5690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2980   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0125   -5.5690    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7269   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7269   -6.8065    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4414   -7.2190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1559   -6.8065    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1559   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4414   -5.5690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6129   -4.7621    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4334   -4.6758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9183   -4.0084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7388   -4.0946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0744   -4.8483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8948   -4.9346    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    8.5894   -5.5158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7690   -5.4295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3941

>  <JC_XSMILES>
CN(C)CCCNC1=NC=NC2=C1NC3=CC=C(Br)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0481

>  <W2 Pf proliferation inhibition EC50 uM>
0.2312

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
26.47

>  <Powder data?>
Yes

>  <IFI value>
0.04

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3942
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    6.6784    1.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3813   -0.2736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2046   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
 12 18  4  0  0  0  0
 10 19  4  0  0  0  0
  6 19  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  11
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3942

>  <JC_XSMILES>
CC(C)CSC1=NN=C2C(NC3=C(C)C=CC=C23)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.48

>  <W2 Pf proliferation inhibition EC50 uM>
0.873

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.107142857

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3944
  Mrv1591402191617072D          

 34 39  0  0  0  0            999 V2000
    6.4938   -3.1948    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8053   -3.6493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8546   -4.4728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3091   -5.1613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4856   -5.2107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0674   -3.2803    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4148   -3.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6133   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2665   -2.8408    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6355   -2.1029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -1.4898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2765   -1.6613    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7245   -1.0482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9175   -1.2198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3655   -0.6067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4415   -0.7782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9935   -0.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7386    0.6195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0684    0.7910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6204    0.1779    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3385   -0.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1454   -0.5337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6975   -1.1468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4425   -1.9314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0798   -2.4553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4004    0.2510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9154    0.9184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4004    1.5858    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1850    1.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    1.7434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6139    1.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6139    0.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    0.0934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1850    0.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  5  1  0  0  0  0
  2  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 10 24  4  0  0  0  0
 24 25  1  0  0  0  0
  6 25  1  0  0  0  0
 22 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 26 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3944

>  <JC_XSMILES>
O=C(C1CC1)N2CCOC3=C(OCCC4=CC=CC=N4)C=C(C=C3C2)C5=CSC6=CC=CC=C56

>  <PF proliferation inhibition 3D7 EC50 uM>
0.711

>  <W2 Pf proliferation inhibition EC50 uM>
0.594

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
68.25

>  <Powder data?>
Yes

>  <IFI value>
0.00952381

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3948
  Mrv1591402191617072D          

 28 33  0  0  0  0            999 V2000
    0.4601    0.3144    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9445    0.9822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6084    1.7356    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0928    2.4034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7567    3.1568    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9133    2.3178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3978    2.9856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2183    2.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5544    2.1466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3750    2.0610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9877    2.6135    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7024    2.2016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4869    2.4571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1004    1.9055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9295    1.0984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1451    0.8429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5315    1.3945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7111    1.3076    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2267    0.6398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5629   -0.1136    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4062    0.7254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9218    0.0576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1012    0.1432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7651    0.8966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2495    1.5644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0700    1.4788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8848    2.1611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6692    2.4166    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  2  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
 24 25  4  0  0  0  0
  6 25  4  0  0  0  0
 25 26  4  0  0  0  0
  9 26  4  0  0  0  0
 21 26  4  0  0  0  0
 14 27  1  0  0  0  0
 27 28  3  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   3
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3948

>  <JC_XSMILES>
O=C1NC(=O)C2=CC=C3C4=NC5=CC(=CC=C5N4C(=O)C6=CC=C1C2=C36)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
3.94

>  <W2 Pf proliferation inhibition EC50 uM>
0.867

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.164179104

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-395
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  2  0  0  0  0
 17 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 15 22  4  0  0  0  0
 22 23  4  0  0  0  0
 12 23  4  0  0  0  0
  7 24  4  0  0  0  0
  3 24  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  21
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-395

>  <JC_XSMILES>
CCC1=CC=CC(NS(=O)(=O)C2=CC=C3NC(=O)C(=O)NC3=C2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.043

>  <W2 Pf proliferation inhibition EC50 uM>
>1.448

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3952
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   14.2894   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   13.5749   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
 12  4  1  4  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
 17 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 15 30  4  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 31 37  1  0  0  0  0
M  CHG  4   9   1  10  -1  25   1  26  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3952

>  <JC_XSMILES>
COC1=C(C=CC=C1[N+]([O-])=O)C=NNC2=NC(NC3=CC=C(C=C3)[N+]([O-])=O)=NC(=N2)N4CCN(C)CC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.34

>  <W2 Pf proliferation inhibition EC50 uM>
0.493

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
56.93

>  <Powder data?>
Yes

>  <IFI value>
0.064935065

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3956
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2869   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4849   -1.8076    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5269   -3.5692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9966   -4.4877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  9 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  3  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 13 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 20 28  1  0  0  0  0
 12 29  4  0  0  0  0
  6 29  4  0  0  0  0
 29 30  4  0  0  0  0
  3 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3956

>  <JC_XSMILES>
COC1=CC=C2C=CC(OC)=C(C3C(C#N)=C(N)OC4=C3C(=O)CC(C)(C)C4)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.448

>  <W2 Pf proliferation inhibition EC50 uM>
0.864

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3957
  Mrv1591402191617072D          

 43 48  0  0  0  0            999 V2000
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -4.2703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0087   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0087   -7.1282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8337   -7.1282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2462   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8337   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0087   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8337   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8337   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 17 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
  5 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
 42 43  4  0  0  0  0
 35 43  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  43
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3957

>  <JC_XSMILES>
COC1=CC(=CC=C1OC2CCN(CC2)CC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)NCCC5=CC6=CC=CC=C6N5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.803

>  <W2 Pf proliferation inhibition EC50 uM>
0.0944

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.94

>  <Powder data?>
No

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3959
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3058    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8933    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0863    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
  5 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  1  0  0  0  0
 14 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 13 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3959

>  <JC_XSMILES>
CC(=O)N(C1=CC=C(F)C(F)=C1)C2=C(N3CCCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.407

>  <W2 Pf proliferation inhibition EC50 uM>
0.1737

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.2

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3960
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.5763   -4.1479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2907   -4.5604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2907   -5.3854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0052   -4.1479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7197   -4.5604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4342   -4.1479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1486   -4.5604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1486   -5.3854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8631   -5.7979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5776   -5.3854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5776   -4.5604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8631   -4.1479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0346   -3.3410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8551   -3.2547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3400   -2.5873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1605   -2.6735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4961   -3.4272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3165   -3.5134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0111   -4.0946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1907   -4.0084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 14 20  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  13
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3960

>  <JC_XSMILES>
CN(C)CCNC1=NC=NC2=C1NC3=CC=C(C)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1681

>  <W2 Pf proliferation inhibition EC50 uM>
0.2542

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
29.58

>  <Powder data?>
Yes

>  <IFI value>
0.098039216

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3964
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
   -0.9429    4.0641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -3.9979    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 10 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
 15 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 25 26  1  0  0  0  0
 14 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 35 36  4  0  0  0  0
 30 36  4  0  0  0  0
 36 37  1  0  0  0  0
  5 38  4  0  0  0  0
 38 39  4  0  0  0  0
  2 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3964

>  <JC_XSMILES>
CC1=CC=C(NC(=O)C2=C3NC(C)=C(C(N3N=C2)C4=CC(Br)=CC=C4F)C(=O)NC5=CC=C(C)C=C5C)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.55

>  <W2 Pf proliferation inhibition EC50 uM>
0.857

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3965
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -1.5356    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    1.1759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -1.7116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.0215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6486   -4.4736    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8538   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0333   -4.3874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6977   -3.6337    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5484   -5.0548    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2721   -4.9686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7571   -5.6360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5775   -5.5498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9131   -4.7961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4282   -4.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6077   -4.2149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.0215    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212   -0.4741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  7  6  1  4  0  0  0
  7  8  2  0  0  0  0
  9  8  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 14 25  1  0  0  0  0
 10 25  1  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3965

>  <JC_XSMILES>
COC1=CC=C(C=NN=C2NC(=O)C(CC(=O)NC3=CC=CC=C3)S2)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.482

>  <W2 Pf proliferation inhibition EC50 uM>
0.857

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3966
  Mrv1591402191617072D          

 35 37  0  0  0  0            999 V2000
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0572   -6.1830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2502   -6.3545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8377   -5.6400    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3897   -5.0269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2182   -4.2200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4336   -3.9650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2621   -3.1581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8752   -2.6060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6598   -2.8610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2729   -2.3089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8313   -3.6679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6159   -3.9229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9146   -7.1082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5791   -7.8619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1610   -6.7726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6683   -7.4437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 11 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  4 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  2  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3966

>  <JC_XSMILES>
CC(C)N(CC(=O)NC1=CC(=NN1C2=CC=CC(C)=C2C)C(C)(C)C)C(=O)\C=C\C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.75

>  <W2 Pf proliferation inhibition EC50 uM>
0.0855

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009259259

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3967
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 12 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 11 27  1  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3967

>  <JC_XSMILES>
CC(C)OC(=O)C1=C(C)NC2=C(C1C3=CC=CC(=C3)[N+]([O-])=O)C(=O)CCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.12

>  <W2 Pf proliferation inhibition EC50 uM>
0.854

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011494253

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3968
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -4.6480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -6.0770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 21 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3968

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)S(=O)(=O)C3=C(C)C=C(C)C=C3C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1668

>  <W2 Pf proliferation inhibition EC50 uM>
0.2288

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
26.82

>  <Powder data?>
Yes

>  <IFI value>
0.047169811

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-397
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  1  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 10 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-397

>  <JC_XSMILES>
N(C1=CC=NC=C1)C2=CC(=NC(=N2)C3=CC=CC=C3)C4=CC=CN=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.884

>  <W2 Pf proliferation inhibition EC50 uM>
1.443

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3970
  Mrv1591402191617072D          

 46 50  0  0  0  0            999 V2000
    7.8592   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -12.3750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 17 27  1  0  0  0  0
 27 28  1  0  0  0  0
 14 28  1  0  0  0  0
  8 29  4  0  0  0  0
 29 30  4  0  0  0  0
  5 30  4  0  0  0  0
  2 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 39 44  4  0  0  0  0
 35 45  1  0  0  0  0
 45 46  1  0  0  0  0
 32 46  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3970

>  <JC_XSMILES>
OC(COC1=CC=C(OCC(O)CN2CCN(CCOC3=CC=CC=C3)CC2)C=C1)CN4CCN(CCOC5=CC=CC=C5)CC4

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.02

>  <W2 Pf proliferation inhibition EC50 uM>
0.853

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3971
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    0.6622   -2.9756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6622   -3.8006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3297   -4.2856    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0747   -5.0702    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2497   -5.0702    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0052   -4.2856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7898   -4.0306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4029   -4.5827    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9614   -3.2237    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7460   -2.9687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9175   -2.1617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7021   -1.9068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3696   -2.3917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0370   -1.9068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7821   -1.1222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9571   -1.1222    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2670   -0.4547    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -5.0875   -0.5410    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.9314    0.2989    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
 10  9  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
M  CHG  2  17   1  18  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3971

>  <JC_XSMILES>
CC1=NON=C1C(=O)NN=CC2=CC=C(O2)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.727

>  <W2 Pf proliferation inhibition EC50 uM>
0.42

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
49.28

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3975
  Mrv1591402191617072D          

 31 32  0  0  0  0            999 V2000
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -6.0770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 17 24  4  0  0  0  0
  9 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
 25 31  4  0  0  0  0
  6 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3975

>  <JC_XSMILES>
CC(C)(C)CC1=CC=C(OCCCC(=O)NC2=CC=C(Cl)C(N)=C2)C(CC(C)(C)C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.734

>  <W2 Pf proliferation inhibition EC50 uM>
0.848

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.083969466

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3976
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    5.8293    1.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0223    1.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2243   -1.1567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1347   -1.5983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6867   -2.2114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4937   -2.0399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7486   -1.2553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1966   -0.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.7556    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1544    1.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9614    1.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2163    2.4963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 22 27  4  0  0  0  0
 11 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3976

>  <JC_XSMILES>
CCCN1CCC2=C(C1)SC3=C2C(=O)N(C4=CC=CC=C4)C(SCC=C)=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.634

>  <W2 Pf proliferation inhibition EC50 uM>
0.847

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.078431373

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3977
  Mrv1591402191617072D          

 33 34  0  0  0  0            999 V2000
    1.2564    2.2948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2564    1.4698    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9709    1.0573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9709    0.2323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2564   -0.1802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2564   -1.0052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9239   -1.4901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6689   -2.2748    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8439   -2.2748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5890   -1.4901    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3590   -2.9422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6139   -3.7268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0535   -4.2117    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7209   -3.7268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4660   -2.9422    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5056   -3.9818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1187   -3.4297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6771   -4.7887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4617   -5.0437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6332   -5.8506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4179   -6.1056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5894   -6.9126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3740   -7.1675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9763   -7.4646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6854    1.4698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3998    1.0573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6854    2.2948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9709    2.7073    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9709    3.5323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3998    2.7073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3998    3.5323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6854    3.9448    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1143    3.9448    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  3 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  2  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3977

>  <JC_XSMILES>
COC(\C=C\C1=CSC(=N1)C2=CSC(=N2)C(C)\C=C\C=C\C(C)C)C(C)\C(OC)=C\C(N)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.235

>  <W2 Pf proliferation inhibition EC50 uM>
0.0846

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.115384615

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3978
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    1.4401   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1546   -5.5690    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1546   -4.7440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8690   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5835   -5.5690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2980   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0125   -5.5690    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7269   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7269   -6.8065    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4414   -7.2190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1559   -6.8065    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1559   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4414   -5.5690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6129   -4.7621    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4334   -4.6758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9183   -4.0084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7388   -4.0946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0744   -4.8483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8948   -4.9346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5894   -5.5158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7690   -5.4295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3978

>  <JC_XSMILES>
CN(C)CCCNC1=NC=NC2=C1NC3=CC=C(C)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0777

>  <W2 Pf proliferation inhibition EC50 uM>
0.355

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
41.98

>  <Powder data?>
Yes

>  <IFI value>
0.117647059

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-398
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    4.3489    1.5727    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5365    2.9799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8186    3.7552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6311    3.8984    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1614    3.2664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8792    2.4912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9133    4.6737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7257    4.8169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0079    5.5922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8204    5.7354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3507    5.1035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0685    4.3282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2560    4.1850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9739    3.4097    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.8085    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    2.2374    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
  2 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 21 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 28 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-398

>  <JC_XSMILES>
OC1(CCN(CC1)CC2=CC=CC=C2F)C3=CC=C4OC(=CC4=C3)C(=O)NC5=CC=C(F)C(F)=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.495

>  <W2 Pf proliferation inhibition EC50 uM>
1.851

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.83

>  <Powder data?>
Yes

>  <IFI value>
0.02970297

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3984
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    7.0714    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -0.5422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083   -1.4984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1633   -2.2830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604   -0.8853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -0.1006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    3.1465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604    3.9312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083    4.5442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014    4.3727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  2  0  0  0  0
 13 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 12 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 17 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
  6 33  4  0  0  0  0
 33 34  4  0  0  0  0
  3 34  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3984

>  <JC_XSMILES>
COC1=CC=C(CNCC2=CC3=C(NC2=O)N(N=C3C4=CC=C(C)C=C4)C5=CC=CC=C5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1329

>  <W2 Pf proliferation inhibition EC50 uM>
0.842

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.081081081

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3985
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    2.7512   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -5.4965    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -6.2812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -6.2812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8538   -6.9486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0333   -6.8624    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5484   -7.5298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2721   -7.4436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6077   -6.6899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1228   -6.0224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6977   -6.1087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4282   -6.6036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7637   -5.8500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9131   -7.2711    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7336   -7.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2185   -7.8523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0390   -7.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3745   -7.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8896   -6.3449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0691   -6.4312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1950   -6.9261    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7470   -7.5392    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5007   -7.2037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2152   -7.6162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4145   -6.3832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6075   -6.2117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2720   -5.4580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -5.4965    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
  5 29  4  0  0  0  0
  2 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3985

>  <JC_XSMILES>
CC1=NC=C(CN2CCC(CC2)C(=O)NC3=CC=C(C=C3)N4N=C(C)C=C4C)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.811

>  <W2 Pf proliferation inhibition EC50 uM>
0.84

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3986
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 14 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3986

>  <JC_XSMILES>
CC(C)(C)CC(=O)NCCCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02069

>  <W2 Pf proliferation inhibition EC50 uM>
0.1021

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>12.17

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-399
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
   -1.5395   -6.7914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.7914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -6.0770    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230   -6.0770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9355   -6.7914    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9355   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7605   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1730   -4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7605   -3.9336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1730   -3.2191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9980   -3.2191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4105   -3.9336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9980   -4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4105   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9980   -6.0770    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4105   -6.7914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2355   -6.7914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6480   -6.0770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4730   -6.0770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8855   -6.7914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4730   -7.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6480   -7.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-399

>  <JC_XSMILES>
CCN(CC)C(=O)COC1=CC=CC=C1CNCC2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.441

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3990
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    3.1465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9900    2.8916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8185    3.6986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1806    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5306    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.9979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6123    4.3559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4287    5.1602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9431    5.8052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7681    5.8052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2825    5.1602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0989    4.3559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 11 13  1  0  0  0  0
  5 14  4  0  0  0  0
 14 15  4  0  0  0  0
  2 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 19 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3990

>  <JC_XSMILES>
BrC1=CC2=C(N(CC2)C(=O)C3CC3)C(=C1)S(=O)(=O)N4CCCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.431

>  <W2 Pf proliferation inhibition EC50 uM>
0.834

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3991
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1487   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5612    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3862    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7987   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6237   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0362   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6237   -1.6839    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8612   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3461   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1308   -0.5569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1308   -1.3819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7982   -1.8668    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    8.3461   -1.6368    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3862   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5612   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  6 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 18 23  4  0  0  0  0
 14 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3991

>  <JC_XSMILES>
CCC1=NN=C2SC(=NN12)C3=CC=C(NC(=O)C4=CC=C(Br)O4)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
5.05

>  <W2 Pf proliferation inhibition EC50 uM>
0.833

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3993
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -2.9646    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    8.0652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501    9.3027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    9.3027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    7.2402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    7.2402    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    5.5902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041    3.0428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693    3.0428    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356   10.5402    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.2501   10.9527    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.8212   10.9527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
  5 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
M  CHG  2  26   1  27  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3993

>  <JC_XSMILES>
COC1=CC(=CC=C1NC(=O)CN2CCN(CC2)C(=O)C3=CC=CO3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.597

>  <W2 Pf proliferation inhibition EC50 uM>
0.832

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3994
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
    0.9130   -0.8764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0171    0.3498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7621    1.1344    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0368   -2.7887    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8438   -2.9602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0987   -3.7449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5467   -4.3580    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7397   -4.1864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4848   -3.4018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8017   -5.1426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2496   -5.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5046   -6.5403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9525   -7.1534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1456   -6.9819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8906   -6.1972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4426   -5.5841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  3  0  0  0  0
  3  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
  6 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3994

>  <JC_XSMILES>
CC1=C(C#N)C2=NC3=CC=CC=C3N2C(=C1)N4CCN(CC4)CC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.323

>  <W2 Pf proliferation inhibition EC50 uM>
0.832

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046153846

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3995
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 10 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
 33 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3995

>  <JC_XSMILES>
COC1=CC=CC=C1CN2C(=O)C3=CC(Br)=CC=C3N=C2SCC(=O)NC4=CC=CC(=C4)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.735

>  <W2 Pf proliferation inhibition EC50 uM>
0.831

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.043478261

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3997
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 13 20  4  0  0  0  0
 20 21  4  0  0  0  0
  9 21  4  0  0  0  0
  7 22  4  0  0  0  0
  2 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3997

>  <JC_XSMILES>
CC1=CC(C)=NC(NC2=NC(C)=C3C=C(C)C(C)=CC3=N2)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.323

>  <W2 Pf proliferation inhibition EC50 uM>
0.829

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3998
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
   -7.5962   -7.8427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0087   -7.1282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8337   -7.1282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2462   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8337   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2462   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0087   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -4.9848    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0087   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -3.5558    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  4  0  0  0  0
 25 33  4  0  0  0  0
 22 34  4  0  0  0  0
 34 35  4  0  0  0  0
 19 35  4  0  0  0  0
 12 36  1  0  0  0  0
 36 37  1  0  0  0  0
  9 37  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  33
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3998

>  <JC_XSMILES>
CC1=CC=C(C)C(=C1)N2CCN(CCCNC(=O)C3=CC=C(CSC4=NC5=CN=CC=C5N4)C=C3)CC2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.644

>  <W2 Pf proliferation inhibition EC50 uM>
0.1904

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23

>  <Powder data?>
Yes

>  <IFI value>
0.085714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4002
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    0.2154   -5.5781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0224   -5.4066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2773   -4.6220    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0843   -4.4505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7253   -4.0089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9802   -3.2243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4953   -2.5568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9802   -1.8894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7649   -2.1443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5495   -1.8894    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0344   -2.5568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5495   -3.2243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7649   -2.9693    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3297   -2.5568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7422   -3.2713    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7422   -1.8424    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5601   -1.9501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2146   -1.4478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3223   -0.6299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8201    0.0246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0022    0.1323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3476   -0.3699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2400   -1.1879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5744   -6.0197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3949   -5.9335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8074   -5.2190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7305   -6.6872    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1174   -7.2392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2036   -8.0597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4029   -6.8267    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  6 13  4  0  0  0  0
  9 13  4  0  0  0  0
  7 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 16 23  1  0  0  0  0
  2 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4002

>  <JC_XSMILES>
CC(N(C)CC1=C(N=C2SC=CN12)C(=O)N3CCCCCCC3)C4=C(C)SC(C)=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
>7.03

>  <W2 Pf proliferation inhibition EC50 uM>
0.825

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4003
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7550   -2.5519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3070   -3.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8945   -3.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0875   -3.7080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  2  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 12 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 10 29  4  0  0  0  0
 29 30  4  0  0  0  0
  6 30  4  0  0  0  0
 30 31  4  0  0  0  0
  3 31  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   7
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4003

>  <JC_XSMILES>
COC1=CC=C2NC(=O)C(CN(C3CCCC3)C(=S)NC4=CC=CC=C4OC)=CC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.995

>  <W2 Pf proliferation inhibition EC50 uM>
0.824

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.02173913

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4006
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 21 27  4  0  0  0  0
 15 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  2  0  0  0  0
 14 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
M  CHG  4  28   1  29  -1  31   1  32  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4006

>  <JC_XSMILES>
COC1=CC=CC=C1NC2=NC3=CC(=C(C=C3N=C2NC4=CC=CC(Cl)=C4)[N+]([O-])=O)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.0822

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4011
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7550   -0.0769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3070   -0.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8945   -1.4045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0875   -1.2330    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6687   -4.1974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8987   -5.6495    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3339   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5492   -3.9425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 11 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 18 30  4  0  0  0  0
 30 31  4  0  0  0  0
  8 31  4  0  0  0  0
 31 32  4  0  0  0  0
  5 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4011

>  <JC_XSMILES>
COC(=O)C1=CC=C2C(=O)N(CC3=CC=CO3)C(SCC(=O)N4N=C(N)C=C4C)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.337

>  <W2 Pf proliferation inhibition EC50 uM>
0.819

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4013
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 21 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4013

>  <JC_XSMILES>
COC1=CC(N)=C(Cl)C=C1C(=O)NCC2CCN(CC2)C3=NC(C)=CC(C)=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.345

>  <W2 Pf proliferation inhibition EC50 uM>
0.531

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
64.88

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4015
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.7145    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  2  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 10 24  4  0  0  0  0
 19 24  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 26 29  4  0  0  0  0
  3 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4015

>  <JC_XSMILES>
COC1=CC(NC(=O)CN2C3=CC=CC=C3C(=O)C4=CC=CC=C24)=CC(OC)=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
2.726

>  <W2 Pf proliferation inhibition EC50 uM>
0.816

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.036144578

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4016
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6039   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2539   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 34 35  4  0  0  0  0
 28 35  4  0  0  0  0
 15 36  4  0  0  0  0
 36 37  2  0  0  0  0
 36 38  4  0  0  0  0
 12 38  4  0  0  0  0
 38 39  4  0  0  0  0
  9 39  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  13
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4016

>  <JC_XSMILES>
CCN(CC)S(=O)(=O)C1=CC=C2NC=C(C(=O)NCCCN3CCN(CC3)C4=CC=C(OC)C=C4)C(=O)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.336

>  <W2 Pf proliferation inhibition EC50 uM>
0.42

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
51.56

>  <Powder data?>
Yes

>  <IFI value>
0.06

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4019
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.4752   -1.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400   -4.0623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0470   -4.2338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5990   -3.6207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4060   -3.7923    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.3441   -2.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2822   -1.8800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
  2 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  1  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4019

>  <JC_XSMILES>
CC(OC1=CC=C(Cl)C=C1C)C(=O)N2CCC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.632

>  <W2 Pf proliferation inhibition EC50 uM>
0.812

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.032258065

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-402
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    3.6791    2.8259    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9646    3.2384    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3771    3.9529    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5521    2.5239    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2501    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5356    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8212    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8212    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067    4.8884    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    4.8884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    4.8884    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3693    3.1660    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6242    2.3813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4492    2.3813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9341    1.7139    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.7041    3.1660    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.5356    4.8884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2501    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 14 19  4  0  0  0  0
  8 20  4  0  0  0  0
 20 21  4  0  0  0  0
  5 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-402

>  <JC_XSMILES>
NS(=O)(=O)C1=CC=C(N\C=C\C(=O)C2=CC=C(Cl)S2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.829

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.69

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4029
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -4.8696   -4.9879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1551   -4.5754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4407   -4.9879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7262   -4.5754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0117   -4.9879    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0117   -5.8129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2973   -6.2254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2973   -4.5754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5828   -4.9879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1317   -4.5754    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8462   -4.9879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8462   -5.8129    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5606   -4.5754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3143   -4.9110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8663   -4.2979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4538   -3.5834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6469   -3.7550    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0059   -2.9703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8343   -2.1634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7595   -3.3059    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6733   -4.1264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2864   -4.6784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0710   -4.4235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6841   -4.9755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5126   -5.7825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1257   -6.3345    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.7280   -6.0374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1149   -5.4854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4029

>  <JC_XSMILES>
CCCCN(CC)CCNC(=O)C1=CC2=C(S1)N(C)N=C2C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0898

>  <W2 Pf proliferation inhibition EC50 uM>
0.32

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
39.81

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4031
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
    6.3545    1.2502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0690    0.8377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7834    1.2502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4979    0.8377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2124    1.2502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9269    0.8377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6413    1.2502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6413    2.0752    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.3558    0.8377    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.0703    1.2502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0703    2.0752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7847    2.4877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4992    2.0752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4992    1.2502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7847    0.8377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7847    0.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4522   -0.4722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2368   -0.2173    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.8499   -0.7693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2979   -1.3824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.4019   -0.1562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.4630   -1.3213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.2476   -1.0664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0322   -0.8115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.5026   -1.8510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.9927   -0.2818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1972   -1.2568    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.6097   -1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1972   -2.6858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3722   -2.6858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9597   -3.4003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9597   -1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3722   -1.2568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1173   -0.4722    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 17 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
 33 34  4  0  0  0  0
 16 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4031

>  <JC_XSMILES>
CCCCCCC(=O)OC1=CC=CC=C1C2=C(NC(C)(C)CC(C)(C)C)N3C=CC(C)=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.636

>  <W2 Pf proliferation inhibition EC50 uM>
0.0803

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.021276596

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4033
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8810   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4941   -3.2570    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2787   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4502   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2349   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8480   -2.4922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6764   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8918   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7203   -4.3611    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.4064   -1.1332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5779   -0.3262    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.5994   -0.9617    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.2134   -1.3047    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0339   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8186   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9901   -2.4922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3770   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5924   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9793   -1.6431    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 15 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 10 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  9 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4033

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2C(CNC3=CC(=CC=C3Cl)C(F)(F)F)=NN=C2SCC4=CC=CC=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.728

>  <W2 Pf proliferation inhibition EC50 uM>
0.801

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.017241379

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4035
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    4.2584    1.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9728    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9728    2.3568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6873    1.1193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4018    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1162    1.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1162    0.2943    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8307    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5452    1.1193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2989    1.4548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5538    2.2395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3608    2.4110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9128    1.7979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7198    1.9694    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.6579    1.0133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8509    0.8418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4384    0.1273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6933   -0.6573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1413   -1.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3962   -2.0551    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.3343   -1.0989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0794   -0.3143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6314    0.2988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  9 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4035

>  <JC_XSMILES>
CC(C)NCC(O)CN1C2=CC=C(Cl)C=C2C3=CC(Cl)=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1832

>  <W2 Pf proliferation inhibition EC50 uM>
0.0389

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.87

>  <Powder data?>
Yes

>  <IFI value>
0.042553191

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4036
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 11 18  4  0  0  0  0
  9 19  4  0  0  0  0
  2 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4036

>  <JC_XSMILES>
CC1=NC2=NN=CN2C(NC3=CC=C(C)C(C)=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2419

>  <W2 Pf proliferation inhibition EC50 uM>
0.59

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>73.9

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4037
  Mrv1591402191617072D          

 20 23  0  0  0  0            999 V2000
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7780   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2629    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7780    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  8 16  4  0  0  0  0
 16 17  4  0  0  0  0
  2 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4037

>  <JC_XSMILES>
N=C1C2=C(CCC2)N(CC3=CC=CC=C3)C4=C1CCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2805

>  <W2 Pf proliferation inhibition EC50 uM>
0.329

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
41.24

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4038
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    8.7814    0.1136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9745    0.2851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4224   -0.3280    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6155   -0.1564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3605    0.6282    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0634   -0.7695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3184   -1.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7663   -2.1672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9594   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7044   -1.2111    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2564   -0.5980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3454   -1.6527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9524    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 18 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4038

>  <JC_XSMILES>
CCOC(=O)C1CCCN(C1)C(=O)C2=C(C)OC3=C2C(=O)C4=CC=CC=C4C3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.171

>  <W2 Pf proliferation inhibition EC50 uM>
0.1627

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.42

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4040
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
   -0.2649   -2.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5597   -2.2275    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9943   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6043   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0390   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8636   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2982    0.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1228    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5574    1.2530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -0.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3140   -0.3719    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3745   -1.1947    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6108   -1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4141   -2.3078    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6219   -2.5381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4253   -3.3393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0208   -3.9102    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6331   -3.5696    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4364   -4.3709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6442   -4.6012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0487   -4.0303    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2453   -3.2290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0375   -2.9987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7435   -4.2606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3391   -3.6897    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9402   -5.0618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4076   -5.6918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8422   -6.3931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6434   -6.1964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7040   -5.3736    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0781   -0.8765    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2535   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8189   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
 13 31  4  0  0  0  0
 10 31  4  0  0  0  0
 31 32  4  0  0  0  0
  6 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4040

>  <JC_XSMILES>
COC1=CC=C2C=C(C)C3=NN=C(SCC(=O)N4CCN(CC4)C(=O)C5=CC=CO5)N3C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.127

>  <W2 Pf proliferation inhibition EC50 uM>
0.796

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03539823

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4042
  Mrv1591402191617072D          

 35 37  0  0  0  0            999 V2000
    6.3545    1.2502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0690    0.8377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7834    1.2502    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4979    0.8377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4979    0.0127    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2124    1.2502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9269    0.8377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6413    1.2502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6413    2.0752    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.3558    0.8377    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.0703    1.2502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0703    2.0752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7847    2.4877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4992    2.0752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4992    1.2502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7847    0.8377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7847    0.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4522   -0.4722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2368   -0.2173    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.8499   -0.7693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2979   -1.3824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.4019   -0.1562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.4630   -1.3213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.2476   -1.0664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0322   -0.8115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.5026   -1.8510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.9927   -0.2818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1972   -1.2568    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.6097   -1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1972   -2.6858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3722   -2.6858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9597   -3.4003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9597   -1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3722   -1.2568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1173   -0.4722    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 18 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 33 34  4  0  0  0  0
 28 34  4  0  0  0  0
 34 35  4  0  0  0  0
 17 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4042

>  <JC_XSMILES>
CCOC(=O)CCC(=O)OC1=CC=CC=C1C2=C(NC(C)(C)CC(C)(C)C)N3C=CC(C)=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.658

>  <W2 Pf proliferation inhibition EC50 uM>
0.0795

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.046728972

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4043
  Mrv1591402191617072D          

 15 15  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  3  0  0  0  0
 10 13  1  0  0  0  0
 13 14  3  0  0  0  0
  6 15  4  0  0  0  0
  2 15  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4043

>  <JC_XSMILES>
CC1=CC=NC(NC(C)=C(C#N)C#N)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.549

>  <W2 Pf proliferation inhibition EC50 uM>
0.795

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4044
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
  9 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
  6 23  4  0  0  0  0
  4 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
M  CHG  2  19   1  20  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4044

>  <JC_XSMILES>
CC1=CC(=NC2=CC=C(NC(=O)C3=CC=CC(=C3)[N+]([O-])=O)C=C12)N4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.44

>  <W2 Pf proliferation inhibition EC50 uM>
0.793

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.080645161

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4045
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -4.2868    4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9849    2.9980    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599    4.4270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8971    2.3981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4491    1.7850    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0366    1.0705    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2296    1.2420    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4045

>  <JC_XSMILES>
FC(F)(F)C1=CC=C(C=C1)C(=O)NNC(=O)C2=CSN=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.641

>  <W2 Pf proliferation inhibition EC50 uM>
0.792

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4046
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
   -2.1434   11.7161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   10.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    8.4161    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    8.4161    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    7.1786    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.7661    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0470    5.4562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020    4.6715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    4.6715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3819    5.4562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
  5 16  4  0  0  0  0
 16 17  4  0  0  0  0
  2 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4046

>  <JC_XSMILES>
CC1=CC=C(NC(=O)ON=C2CCCC2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.408

>  <W2 Pf proliferation inhibition EC50 uM>
0.362

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
45.72

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4047
  Mrv1591402191617072D          

 20 23  0  0  0  0            999 V2000
   -1.8703    2.2641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9982    1.4491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7680    1.1524    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3563    0.9308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4843    0.1158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8424   -0.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0726   -0.1058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8353   -0.4881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9089   -1.3098    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5265   -0.0378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2621   -0.4113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9534    0.0390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9091    0.8628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1735    1.2363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4822    0.7860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7466    1.1595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0553    0.7092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5866    1.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2920    1.9981    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5320    1.9561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 17 18  4  0  0  0  0
  4 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4047

>  <JC_XSMILES>
CC(=O)C1=CC=C2C(=O)C3=CC=CC=C3C4=C2C1=NO4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.249

>  <W2 Pf proliferation inhibition EC50 uM>
0.791

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4053
  Mrv1591402191617072D          

 39 43  0  0  1  0            999 V2000
   -2.5058    0.6410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2594    0.3055    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3457   -0.5150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0994   -0.8505    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6782   -0.9999    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.8936   -0.7450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.8936   -2.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6782   -1.8249    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3457   -2.3098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2594   -3.1303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5058   -3.4659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4195   -4.2864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6659   -4.6219    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5796   -5.4424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0870   -4.7713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8407   -4.4357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5081   -4.9206    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2618   -4.5851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9269   -3.6152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  5  3  1  6  0  0  0
  5  6  1  0  0  0  0
  7  6  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 13 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 11 20  4  0  0  0  0
  7 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 25 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 32 38  4  0  0  0  0
 38 39  4  0  0  0  0
 24 39  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  39
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4053

>  <JC_XSMILES>
COC(=O)[C@@H]1C[C@@H](CN1CC2=CC(OC)=CC(OC)=C2)NC(=O)C3=C(C4=CC=CC=C4)C5=CC(Cl)=CC=C5N3

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.51

>  <W2 Pf proliferation inhibition EC50 uM>
0.786

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.017699115

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4054
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6116   -2.8106    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1636   -2.1975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9886   -2.1975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4011   -1.4830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9886   -0.7685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1636   -0.7685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7511   -1.4830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9441   -1.6545    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
  2 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  2  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
 19 29  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4054

>  <JC_XSMILES>
O=C(NC1=CC=CC(=C1)C2=NC3=CC=CC=C3N2)C4=CC(=O)C5=CC=CC=C5O4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.397

>  <W2 Pf proliferation inhibition EC50 uM>
0.786

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023255814

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4055
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 10 16  4  0  0  0  0
  5 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
  4 25  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4055

>  <JC_XSMILES>
CN(C)C1=C(N(C(C)=O)C2=CC=CC(F)=C2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01348

>  <W2 Pf proliferation inhibition EC50 uM>
0.01064

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.356

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4056
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4056

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C(Cl)=CC=CC2=C1NC3=CC=CC(=C3)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.785

>  <W2 Pf proliferation inhibition EC50 uM>
0.784

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.032786885

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4057
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
 16 17  1  0  0  0  0
  8 18  4  0  0  0  0
  4 18  4  0  0  0  0
 18 19  2  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4057

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CN(CC2=CC=C(F)C=C2Cl)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.358

>  <W2 Pf proliferation inhibition EC50 uM>
0.783

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-406
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5152   -4.9455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3221   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7346   -4.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1826   -3.7894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 26 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-406

>  <JC_XSMILES>
FC1=CC=CC=C1CSC2=NC3=CC=CC=C3C(=O)N2CCCC(=O)N4CCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.059

>  <W2 Pf proliferation inhibition EC50 uM>
>1.436

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4060
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    4.0954   -3.1895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -3.1895    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7809   -3.9431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1678   -4.4952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4534   -4.0827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6249   -3.2757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6997   -4.4182    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6135   -5.2387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2809   -5.7236    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1402   -5.5743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2264   -6.3948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9801   -6.7303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6476   -6.2454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5613   -5.4249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8076   -5.0894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.7605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -0.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -0.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8079   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 19 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  2  0  0  0  0
 27 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4060

>  <JC_XSMILES>
OC(CN1CCC(C1)NC(=O)C2=CC=CC=C2)CN(CC3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0819

>  <W2 Pf proliferation inhibition EC50 uM>
0.0569

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>7.27

>  <Powder data?>
No

>  <IFI value>
0.029411765

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4062
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
   -4.6573    1.6168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8369    1.5306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5013    0.7769    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6808    0.6907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1959    1.3581    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3453   -0.0630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5383   -0.2345    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9252    0.3175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4521   -1.0550    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -1.0550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6914   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6914   -2.2925    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4058   -1.0550    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1203   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8348   -1.0550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8348   -0.2300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5492    0.1825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2637   -0.2300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9782    0.1825    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6926   -0.2300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2637   -1.0550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5492   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2057   -1.3905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7578   -0.7774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3773   -2.1975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7642   -2.7495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9357   -3.5565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7203   -3.8115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8918   -4.6184    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6765   -4.8734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3334   -3.2594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1619   -2.4525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 22 23  4  0  0  0  0
 16 23  4  0  0  0  0
  9 24  4  0  0  0  0
 24 25  4  0  0  0  0
  6 25  4  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  4  0  0  0  0
 26 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4062

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N(CCC(=O)NCC2=CC=C(OC)C=C2)C(=C1)C3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.987

>  <W2 Pf proliferation inhibition EC50 uM>
0.781

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4064
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1369   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6218   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1369   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3053   -2.8329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0503   -3.6175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2253   -3.6175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9704   -2.8329    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 12 18  4  0  0  0  0
  2 18  4  0  0  0  0
  5 18  4  0  0  0  0
  3 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4064

>  <JC_XSMILES>
NC1=C(SC2=NC3=C(CCC3)C(C4=CC=CS4)=C12)C(=O)NC5=CC=C(Br)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.037

>  <W2 Pf proliferation inhibition EC50 uM>
0.776

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023255814

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4065
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
  6 12  4  0  0  0  0
  4 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
  2 20  4  0  0  0  0
 14 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4065

>  <JC_XSMILES>
CC1=CC(NC2=CC=C(O)C=C2)=NC3=CC=CC(O)=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.468

>  <W2 Pf proliferation inhibition EC50 uM>
0.407

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
52.45

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4066
  Mrv1591402191617072D          

 23 27  0  0  0  0            999 V2000
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4710    1.3770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1354    2.1307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3149    2.0445    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  4  0  0  0  0
  6 21  1  0  0  0  0
 21 22  4  0  0  0  0
  9 22  1  0  0  0  0
 14 22  4  0  0  0  0
  7 23  4  0  0  0  0
  3 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4066

>  <JC_XSMILES>
COC1=CC=C2C(CC3N(C)CCC4=CC5=C(OCO5)C2=C34)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0385

>  <W2 Pf proliferation inhibition EC50 uM>
0.121

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.6

>  <Powder data?>
Yes

>  <IFI value>
0.25

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4067
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2890   -4.3257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8671   -5.1657    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3822   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7177   -6.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2328   -7.2542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5877   -7.1680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9232   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4383   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7739   -4.9932    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4067

>  <JC_XSMILES>
CCC1=CC=C(C=C1)N2N=NC(=C2C)C(=O)NC3=CC=CC=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.681

>  <W2 Pf proliferation inhibition EC50 uM>
0.0775

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4068
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  3  9  4  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4068

>  <JC_XSMILES>
COC1=CC=C(C(O)=C1)C2=NNC(=C2)C3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.516

>  <W2 Pf proliferation inhibition EC50 uM>
0.1977

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
25.56

>  <Powder data?>
Yes

>  <IFI value>
0.106060606

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-407
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2136   -5.2049    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6985   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2136   -3.8701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
  7 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 35 39  4  0  0  0  0
 39 40  4  0  0  0  0
 32 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-407

>  <JC_XSMILES>
CCCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3OC)C(=O)C4=CC=C5OCOC5=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.862

>  <W2 Pf proliferation inhibition EC50 uM>
0.647

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>4.51

>  <Powder data?>
No

>  <IFI value>
0.009708738

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4070
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 13 16  4  0  0  0  0
  9 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4070

>  <JC_XSMILES>
COC1=NN=CC(=N1)C2=CN=NC(SC)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2366

>  <W2 Pf proliferation inhibition EC50 uM>
0.2191

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
28.35

>  <Powder data?>
Yes

>  <IFI value>
0.046153846

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4074
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 16 27  4  0  0  0  0
 11 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4074

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CNCCC3=CC=CC=C3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.657

>  <W2 Pf proliferation inhibition EC50 uM>
0.0771

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008474576

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4075
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    2.5559    2.4856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3739    2.3779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6896    1.6157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1874    0.9612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3694    1.0689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0537    1.8311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5031    0.1990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3281    0.1990    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9114   -0.3844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6259    0.0281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3404   -0.3844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3404   -1.2094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6259   -1.6219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9114   -1.2094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3281   -1.7928    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5031   -1.7928    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1874   -2.5550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6896   -3.2095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3739   -3.9717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -4.0794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0537   -3.4248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3694   -2.6626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9197   -1.2094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2053   -1.6219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4908   -1.2094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4908   -0.3844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2053    0.0281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9197   -0.3844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  4  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  1  6  4  0  0  0  0
  4  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  4  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 15 14  1  4  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 16 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
  7 28  1  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4075

>  <JC_XSMILES>
C1=CC=C(C=C1)C2=NC3=CC=CC=C3N=C(C4=CC=CC=C4)C5=CC=CC=C25

>  <PF proliferation inhibition 3D7 EC50 uM>
0.678

>  <W2 Pf proliferation inhibition EC50 uM>
0.77

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011494253

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4079
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -2.1730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -3.6020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
 12  9  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 15 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 13 32  1  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4079

>  <JC_XSMILES>
COC1=CC=C(C=C1)S(=O)(=O)N=C2C=C(NC3=CC=CC=C3OC)C(=O)C4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.338

>  <W2 Pf proliferation inhibition EC50 uM>
0.1545

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.09

>  <Powder data?>
Yes

>  <IFI value>
0.230769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-408
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9731   -4.0144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4580   -3.3470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2785   -3.4332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6140   -4.1869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1291   -4.8543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3086   -4.7681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3088   -3.6695    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0032   -5.3493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4817   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3022   -5.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2960   -0.1085    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 13 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
 12 30  4  0  0  0  0
  9 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 31 37  4  0  0  0  0
 37 38  1  0  0  0  0
  6 39  4  0  0  0  0
  2 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-408

>  <JC_XSMILES>
CC1=CC=CC(CSC2=NN=C(C(CC3=CC=CC=C3)NC(=O)C4CCCCC4)N2C5=CC=C(Cl)C=C5Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.24

>  <W2 Pf proliferation inhibition EC50 uM>
1.43

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.010752688

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4081
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    4.1974    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 15 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 24 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4081

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2CCN(CC2)C(CNC(=O)CC(C)C)C3=CC=CO3

>  <PF proliferation inhibition 3D7 EC50 uM>
6.69

>  <W2 Pf proliferation inhibition EC50 uM>
0.767

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4083
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    3.4815   -1.3651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0783   -1.0950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0138   -0.0149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7933    0.2552    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9493    1.0653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7288    1.3354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3256    1.6054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5461    1.3354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4815    2.4155    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.9556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0138    3.7658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3902    4.3058    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5866    4.1188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1604    4.8251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7005    5.4488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4605    5.1278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0783    2.6856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9224    1.8754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1429    1.6054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5192    2.1455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6751    2.9556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4547    3.2257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4170   -0.2849    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8769   -0.9086    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9571    0.3387    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0406   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8847   -1.6351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5084   -2.1752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3524   -2.9854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5729   -3.2554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9493   -2.7153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1052   -1.9052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 11 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  5 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4083

>  <JC_XSMILES>
CC(C)CN(C(C)C(=O)NC(CN1CCCC1)C2=CC=CC=C2)S(=O)(=O)CC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0602

>  <W2 Pf proliferation inhibition EC50 uM>
0.0767

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019607843

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4084
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    2.7512   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -5.4965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -6.2812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -6.2812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8538   -6.9486    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0333   -6.8624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6977   -6.1087    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5484   -7.5298    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2721   -7.4436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7571   -8.1110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5775   -8.0248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9131   -7.2711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4282   -6.6036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6077   -6.6899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1228   -6.0224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7336   -7.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2185   -7.8523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0390   -7.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3745   -7.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1950   -6.9261    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6799   -7.5936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3444   -8.3473    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5004   -7.5073    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9853   -8.1748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7304   -8.9594    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3978   -9.4443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0653   -8.9594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8499   -9.2143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8103   -8.1748    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8896   -6.3449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2252   -5.5913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0691   -6.4312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -5.4965    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 25 30  4  0  0  0  0
 20 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 17 33  4  0  0  0  0
  5 34  4  0  0  0  0
  2 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4084

>  <JC_XSMILES>
CC1=CN=C(NC(=O)NC2=CC=C(C=C2C)C3=CC=C(NC(=O)NC4=NC=C(C)S4)C(C)=C3)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0341

>  <W2 Pf proliferation inhibition EC50 uM>
0.0767

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4085
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
  6 12  4  0  0  0  0
  4 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 14 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4085

>  <JC_XSMILES>
CC1=CC(NC2=CC=C(Cl)C=C2)=NC(NCC3=CC=CC=C3)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0919

>  <W2 Pf proliferation inhibition EC50 uM>
0.1501

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.58

>  <Powder data?>
Yes

>  <IFI value>
0.046153846

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4086
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    1.4120   -1.7507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9521   -2.3743    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7622   -2.2184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3023   -2.8421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0323   -3.6216    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.2452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1124   -2.6861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3825   -1.9066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8424   -1.2829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1124   -0.5034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9226   -0.3475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4627   -0.9711    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.2728   -0.8152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8129   -1.4389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6230   -1.2829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8931   -0.5034    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7032   -0.3475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1631   -1.9066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9732   -1.7507    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2433   -0.9711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8931   -2.6861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0829   -2.8421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5428   -2.2184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7327   -2.3743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1926   -1.7507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0323   -1.4389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  4  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 14 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
  8 25  1  0  0  0  0
 12 25  4  0  0  0  0
  9 26  4  0  0  0  0
  3 26  4  0  0  0  0
M  CHG  1  12   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4086

>  <JC_XSMILES>
COC1=C(OC)C=C2C(CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C23)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.697

>  <W2 Pf proliferation inhibition EC50 uM>
0.766

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.016129032

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4087
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 27 28  1  0  0  0  0
 16 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 13 31  4  0  0  0  0
 11 32  4  0  0  0  0
  6 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4087

>  <JC_XSMILES>
COC1=CC=C2N=C(C)C=C(NC3=CC=C(OC4=CC=C5C=CC=CC5=C4Cl)C(Cl)=C3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1003

>  <W2 Pf proliferation inhibition EC50 uM>
0.491

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
64.14

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-409
  Mrv1591402191617072D          

 35 36  0  0  0  0            999 V2000
   -2.0921   -5.5539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6796   -4.8395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8546   -4.8395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4421   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8546   -3.4105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3829   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954   -3.4105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204   -3.4105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204   -4.8395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954   -4.8395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -3.4105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954   -3.4105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -2.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -2.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.9816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -1.9816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -1.2671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8079   -1.2671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2204   -1.9816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8079   -2.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -2.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -3.4105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -3.4105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954   -4.8395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -4.8395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -4.8395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -5.5539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -6.2684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0309   -6.6809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4599   -5.8559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -6.9829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 14 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  1  0  0  0  0
 32 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-409

>  <JC_XSMILES>
CCNC(=O)N1CCN(CC1)CCN(C\C=C\C2=CC=CC=C2OC)C(=O)CC(C)CC(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.426

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.025423729

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4090
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    4.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5159    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    2.9519    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4090

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C(C)(C)CCl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.699

>  <W2 Pf proliferation inhibition EC50 uM>
0.0763

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.031578947

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4091
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  8 18  4  0  0  0  0
 12 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4091

>  <JC_XSMILES>
CN(C)CCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0769

>  <W2 Pf proliferation inhibition EC50 uM>
0.0763

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4092
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 10 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 31 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  2  0  0  0  0
 26 37  4  0  0  0  0
  8 37  4  0  0  0  0
  6 38  4  0  0  0  0
 38 39  4  0  0  0  0
  3 39  4  0  0  0  0
M  CHG  4  22   1  23  -1  34   1  35  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4092

>  <JC_XSMILES>
COC1=CC=C(NC2=NC(NN=CC3=CC(=CC=C3OC)[N+]([O-])=O)=NC(NC4=CC=C(C=C4)[N+]([O-])=O)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.728

>  <W2 Pf proliferation inhibition EC50 uM>
0.762

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4096
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -2.1394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -2.7525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -3.4670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731   -3.2955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1904    0.4849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    1.2695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    1.2695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5253    0.4849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
  9 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  10
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4096

>  <JC_XSMILES>
CCC(=O)NNC1=CC(=NC(=N1)N2CCCC2)N3CCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.79

>  <W2 Pf proliferation inhibition EC50 uM>
0.76

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.044444444

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4099
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    0.7017    0.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9566   -0.3087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7413   -0.5636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3863   -0.0492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2027    0.7551    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1906   -0.2328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5485   -0.9761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1906   -1.7194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3863   -1.9030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2027   -2.7073    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7413   -1.3886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9566   -1.6436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7017   -2.4282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4717   -0.9761    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3735   -0.9761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8585   -0.3087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6431   -0.5636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6431   -1.3886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8585   -1.6436    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
  3 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
  2 14  4  0  0  0  0
  7 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4099

>  <JC_XSMILES>
CC1=C2C(O)=CC(=CC(=O)C2=C(C)O1)C3=CC=CS3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.219

>  <W2 Pf proliferation inhibition EC50 uM>
0.758

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027522936

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-410
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.1434   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4694   -2.9644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0215   -3.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6090   -4.2920    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8020   -4.1205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
  5 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-410

>  <JC_XSMILES>
OC1=CC=C(C=C1CNCCCN2C=CN=C2)C3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.059

>  <W2 Pf proliferation inhibition EC50 uM>
1.426

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.00990099

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4101
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2743    3.0830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8577    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2743    4.2497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 29 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4101

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4CCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.822

>  <W2 Pf proliferation inhibition EC50 uM>
0.0757

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028037383

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4103
  Mrv1591402191617072D          

 39 43  0  0  1  0            999 V2000
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  6  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 10 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 17 27  4  0  0  0  0
 22 27  4  0  0  0  0
  7 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
  5 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 36 39  4  0  0  0  0
  3 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4103

>  <JC_XSMILES>
COC1=CC(CN(CC[C@H](C2=CC=CC=C2)C3=C(O)C=CC4=CC=CC=C34)CC5=CC=CC=C5)=CC(OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.702

>  <W2 Pf proliferation inhibition EC50 uM>
0.0754

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.036363636

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4106
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -0.7238    5.7312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3882    4.9775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4188    4.8060    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2487    3.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4202    2.8430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007    4.2631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  9 23  4  0  0  0  0
 17 23  4  0  0  0  0
  4 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4106

>  <JC_XSMILES>
CC1=NN(CC(O)CN2C3=CC=C(Cl)C=C3C4=CC(Cl)=CC=C24)C(C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.013

>  <W2 Pf proliferation inhibition EC50 uM>
0.342

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
45.53

>  <Powder data?>
Yes

>  <IFI value>
0.006944444

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4108
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -0.4752   -1.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400   -4.0623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0470   -4.2338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5990   -3.6207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3441   -2.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8961   -2.2230    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
  4 10  4  0  0  0  0
  2 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  1  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4108

>  <JC_XSMILES>
CC(OC1=CC=CC(Cl)=C1)C(=O)N2CCC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.748

>  <W2 Pf proliferation inhibition EC50 uM>
0.75

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4109
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5395   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
  2 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 26 29  1  0  0  0  0
 29 30  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4109

>  <JC_XSMILES>
CC(NC1=CC=C(C)C(=C1)S(=O)(=O)N2CCCCC2)C(=O)NC3=CC=C(C=C3)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.406

>  <W2 Pf proliferation inhibition EC50 uM>
0.446

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
59.52

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4114
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    0.1190   -4.5039    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -5.2354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 15 24  4  0  0  0  0
  8 24  4  0  0  0  0
 11 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4114

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C2=CSC3=NC=NC(NCC4=CC=NC=C4)=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
2.891

>  <W2 Pf proliferation inhibition EC50 uM>
0.746

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4117
  Mrv1591402191617072D          

 49 53  0  0  0  0            999 V2000
   11.2115    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2115    3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4970    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4970    2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.2115    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2115    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9259    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7825    2.3479    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.3700    3.0624    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.1950    1.6335    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0681    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0681    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    3.5881    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    3.1465    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752    2.5334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2822    2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -0.5422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -1.4984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -0.8853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -0.1006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  2  0  0  0  0
 37 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 36 42  4  0  0  0  0
 32 42  4  0  0  0  0
 42 43  4  0  0  0  0
 29 43  4  0  0  0  0
 33 44  1  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 48 49  4  0  0  0  0
 44 49  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4117

>  <JC_XSMILES>
CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)NC2=CC=CC=C2C(=O)OC3=CC=C4N(C(C)=C(C(=O)OCC)C4=C3)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.726

>  <W2 Pf proliferation inhibition EC50 uM>
0.744

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4119
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -2.6462   -4.9848    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.0587   -4.2703    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.8837   -4.2703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
 10  7  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4119

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)C=NNC2=NC3=CC=CC=C3N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.818

>  <W2 Pf proliferation inhibition EC50 uM>
0.742

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.014705882

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4120
  Mrv1591402191617072D          

 36 38  0  0  0  0            999 V2000
    7.5920    1.9647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3065    1.5522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0209    1.9647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7354    1.5522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4499    1.9647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1644    1.5522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8788    1.9647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5933    1.5522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3078    1.9647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3078    2.7897    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.0222    1.5522    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.7367    1.9647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7367    2.7897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.4512    3.2022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.1657    2.7897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.1657    1.9647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.4512    1.5522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.4512    0.7272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.1186    0.2423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.9032    0.4972    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   17.5163   -0.0548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.9643   -0.6679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.0684    0.5583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.1294   -0.6069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.9141   -0.3519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.6987   -0.0970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.1690   -1.1366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.6591    0.4327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.8637   -0.5424    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   16.2762   -1.2568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.8637   -1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0387   -1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.6262   -2.6858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.6262   -1.2568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0387   -0.5424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7837    0.2423    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 19 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
 35 36  4  0  0  0  0
 18 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4120

>  <JC_XSMILES>
CCCCCCCCC(=O)OC1=CC=CC=C1C2=C(NC(C)(C)CC(C)(C)C)N3C=CC(C)=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.713

>  <W2 Pf proliferation inhibition EC50 uM>
0.074

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.046296296

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4121
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -2.7512    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    1.1759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.8866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -0.8866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -2.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3693   -2.6090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5846   -2.3541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6242   -3.3937    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4492   -3.3937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9341   -4.0611    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7546   -3.9749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0902   -3.2212    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2395   -4.6423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9040   -5.3960    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6577   -5.7315    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1503   -5.0604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5684   -6.1496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7479   -6.2359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4124   -6.9896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8973   -7.6570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7178   -7.5708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0533   -6.8171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7041   -2.6090    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 14 28  4  0  0  0  0
 10 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4121

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)C2=C(C)SC(NC(=O)CS(=O)(=O)C3=CC=CC=C3)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.525

>  <W2 Pf proliferation inhibition EC50 uM>
0.74

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4122
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    3.6020   -3.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895   -2.4454    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375    1.5395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500    2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4750    2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8875    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7125    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1250    3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7125    4.3974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8875    4.3974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4750    3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500    3.6829    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395   -2.4454    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
  5 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
  3 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4122

>  <JC_XSMILES>
COC1=CC(CN2CCC3(CC2)CC3C(=O)NCCC4=CC=CC=C4OC)=CC=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.348

>  <W2 Pf proliferation inhibition EC50 uM>
0.739

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4124
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    0.0000    6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4124

>  <JC_XSMILES>
CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N2CCC(CC2)C3=NC(=NO3)C4=CC=CN=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.64

>  <W2 Pf proliferation inhibition EC50 uM>
0.736

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.157894737

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4125
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 10 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  7 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4125

>  <JC_XSMILES>
CC1=CC=C2C=C3C(N)=C4C=CC=C(C)C4=NC3=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1153

>  <W2 Pf proliferation inhibition EC50 uM>
0.0736

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.127659574

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4127
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.0639   -2.8872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6159   -2.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4229   -2.4457    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4758    0.3498    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9237    0.9629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1787    1.7475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6267    2.3606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8816    3.1452    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3296    3.7583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5845    4.5429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3915    4.7144    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9435    4.1014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6886    3.3167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 10 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  9 24  4  0  0  0  0
 24 25  4  0  0  0  0
  7 25  4  0  0  0  0
 25 26  4  0  0  0  0
  4 26  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4127

>  <JC_XSMILES>
CCOC1=CC=C2NC3=C(NCCCN4CCOCC4)N=CN=C3C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.749

>  <W2 Pf proliferation inhibition EC50 uM>
0.2672

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
36.38

>  <Powder data?>
Yes

>  <IFI value>
0.047619048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4131
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  4  3  1  4  0  0  0
  4  5  2  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
  5 15  4  0  0  0  0
  2 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 16 23  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4131

>  <JC_XSMILES>
OC(CN=C1NC2=CC=CC=C2C(=O)S1)C3=CC=C(Cl)C(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.757

>  <W2 Pf proliferation inhibition EC50 uM>
0.0731

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.073170732

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4136
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
   -1.7575    0.3126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9606    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.9521    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 19 25  4  0  0  0  0
 16 26  4  0  0  0  0
 26 27  4  0  0  0  0
 13 27  4  0  0  0  0
 27 28  2  0  0  0  0
 26 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
 35 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4136

>  <JC_XSMILES>
CC1=CC=CC(C)=C1N2C(=S)SC3=C2N=C(SCC4=CC=CC(F)=C4)N(C3=O)C5=C(C)C=CC=C5C

>  <PF proliferation inhibition 3D7 EC50 uM>
5.16

>  <W2 Pf proliferation inhibition EC50 uM>
0.728

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4137
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  3 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4137

>  <JC_XSMILES>
OC1=C(CN2CCCCC2)C=CC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
5.63

>  <W2 Pf proliferation inhibition EC50 uM>
0.727

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4139
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175   -4.4158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483   -3.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878   -3.3762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489   -2.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227   -3.3151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    4.3034    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8913    2.8744    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 13 18  4  0  0  0  0
 11 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 28 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4139

>  <JC_XSMILES>
CC(C)(C)CC(C)(C)NC1=C(N=C2C=CC=CN12)C3=CC=CC=C3OC(=O)C4=CC=C(Cl)C(Cl)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.92

>  <W2 Pf proliferation inhibition EC50 uM>
0.0723

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.047169811

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-414
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    4.1659    0.5353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1659    1.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4514    1.7728    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7369    1.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7369    0.5353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4514    0.1228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0224    0.1228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3080    0.5353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3080    1.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0224    1.7728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0224    2.5978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8803    1.7728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8803    2.5978    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5948    1.3603    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3093    1.7728    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0237    1.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7774    1.6958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3294    1.0827    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1499    1.1690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4855    1.9226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6349    0.5015    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9169    0.3683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1719   -0.4164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6199   -1.0295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8129   -0.8579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5579   -0.0733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1100    0.5398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
  2 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 15 14  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 18 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 16 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-414

>  <JC_XSMILES>
CC(NC1=C(C)C=CC=C1C)C(=O)NN=C2CN(C(C)=O)C3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
1.956

>  <W2 Pf proliferation inhibition EC50 uM>
1.418

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4141
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 13 21  4  0  0  0  0
 21 22  1  0  0  0  0
 11 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 23 27  1  0  0  0  0
  8 27  1  0  0  0  0
  6 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
  3 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4141

>  <JC_XSMILES>
COC1=CC=C(CN2CCN(CC3=CC=C(OC)C(C)=C3C)C(CCO)C2)C(O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.648

>  <W2 Pf proliferation inhibition EC50 uM>
0.319

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>44.15

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4144
  Mrv1591402191617072D          

 35 37  0  0  0  0            999 V2000
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6993   -0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8743    0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 10 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
  2 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  CHG  2  13   1  14  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4144

>  <JC_XSMILES>
CN(CCCNC1=CC=C(C=C1[N+]([O-])=O)C(=O)NC2=CC=C(C=C2)C(F)(F)F)CC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3158

>  <W2 Pf proliferation inhibition EC50 uM>
0.72

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4146
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0468   -4.1831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4757   -4.1831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1902   -4.5956    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9047   -4.1831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9909   -3.3626    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7979   -3.1911    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1334   -2.4374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9539   -2.3512    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6485   -1.7700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8280   -1.8562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3431   -1.1888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6787   -0.4351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4991   -0.3489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9841   -1.0163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8046   -0.9301    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2895   -1.5975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2104   -3.9056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6583   -4.5187    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0309   -3.9918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5158   -3.3244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3363   -3.4106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6718   -4.1643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4923   -4.2505    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.9772   -3.5831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1869   -4.8317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3664   -4.7455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
  8 19  4  0  0  0  0
 19 20  4  0  0  0  0
  6 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  4  0  0  0  0
 27 28  4  0  0  0  0
 21 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4146

>  <JC_XSMILES>
CCCCOC1=NN(C(=O)C2=CC=CC=C2OC)C(=N1)C3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
8.97

>  <W2 Pf proliferation inhibition EC50 uM>
0.717

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.074074074

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4148
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 10 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  2  0  0  0  0
 22 33  4  0  0  0  0
  8 33  4  0  0  0  0
  6 34  4  0  0  0  0
 34 35  4  0  0  0  0
  3 35  4  0  0  0  0
M  CHG  2  30   1  31  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4148

>  <JC_XSMILES>
COC1=CC=C(NC2=NC(NN=CC3=CC=CC(Cl)=C3)=NC(NC4=CC=C(C=C4)[N+]([O-])=O)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.603

>  <W2 Pf proliferation inhibition EC50 uM>
0.717

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.039473684

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4150
  Mrv1591402191617072D          

 14 15  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
  2 13  4  0  0  0  0
 13 14  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   3
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4150

>  <JC_XSMILES>
CC1=NC2=CC=C(Cl)C=C2C(O)=C1I

>  <PF proliferation inhibition 3D7 EC50 uM>
3.47

>  <W2 Pf proliferation inhibition EC50 uM>
0.714

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.007518797

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4151
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.7145   -2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -1.2375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -1.2375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0875    2.0580    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8945    2.2295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3070    1.5150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7550    0.9019    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9265    0.0950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6802   -0.2406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5939   -1.0611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7870   -1.2326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3745   -0.5181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 21 25  1  0  0  0  0
 10 26  4  0  0  0  0
  5 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4151

>  <JC_XSMILES>
FC(F)(F)C1=CC=C(Cl)C(NC(=O)CSC2=NC=CN2C3CCCC3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.545

>  <W2 Pf proliferation inhibition EC50 uM>
0.714

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4155
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
  8 18  1  0  0  0  0
 12 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4155

>  <JC_XSMILES>
CN(C)CCCNC1=NC=NC2C=C(Cl)C=CC12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2898

>  <W2 Pf proliferation inhibition EC50 uM>
0.713

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012345679

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4156
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
  5 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4156

>  <JC_XSMILES>
ClC1=CC=C(NC(=O)NC2=CC=C(Br)C=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.712

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4158
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -4.2962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -4.2703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
 10  5  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4158

>  <JC_XSMILES>
COC1=CC(=CC=C1O)C=NNC2=NC3=CC=CC=C3N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2054

>  <W2 Pf proliferation inhibition EC50 uM>
0.3066

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
43.09

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4160
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -2.1975   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4830   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7685   -2.7346    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7685   -1.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0541   -1.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0541   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6604   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3749   -3.1471    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0894   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8038   -3.1471    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0894   -1.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3749   -1.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3749   -0.6721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0894   -0.2596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8038   -0.6721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8038   -1.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5183   -0.2596    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6045    0.5608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4115    0.7324    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8240    0.0179    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2720   -0.5952    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6604   -0.2596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0933   -0.5952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6453    0.0179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4703    0.0179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8828    0.7324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4703    1.4468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6453    1.4468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2328    0.7324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5742    0.5608    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 13 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 22 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4160

>  <JC_XSMILES>
CCN(CC)CCNC(=O)C1=CC(=CC(=C1)N2C=NN=N2)C3=CC4=CC=CC=C4S3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0616

>  <W2 Pf proliferation inhibition EC50 uM>
0.1509

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.26

>  <Powder data?>
Yes

>  <IFI value>
0.042372881

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4165
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 10 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  2  0  0  0  0
 22 33  4  0  0  0  0
  8 33  4  0  0  0  0
  6 34  4  0  0  0  0
 34 35  4  0  0  0  0
  3 35  4  0  0  0  0
M  CHG  2  30   1  31  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4165

>  <JC_XSMILES>
COC1=CC=C(NC2=NC(NN=CC3=CC=CC(F)=C3)=NC(NC4=CC=C(C=C4)[N+]([O-])=O)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.662

>  <W2 Pf proliferation inhibition EC50 uM>
0.704

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.039473684

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4166
  Mrv1591402191617072D          

 33 37  0  0  1  0            999 V2000
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.5082    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405    3.6356    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925    3.0225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4130    3.1087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800    2.3080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731    2.4795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7600    1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  6 10  1  0  0  0  0
 11 10  1  0  0  0  0
 11 12  1  6  0  0  0
 13 12  1  6  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
 22 31  4  0  0  0  0
 18 31  4  0  0  0  0
 13 32  1  0  0  0  0
 10 32  1  0  0  0  0
 32 33  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4166

>  <JC_XSMILES>
COC1=CC=C(C=C1Cl)N2[C@H]3C[C@H](N(C3)C(=O)C4=CC=CC(CN5N=C(C)C=C5C)=C4)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>3.8

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4168
  Mrv1591402191617072D          

 75 83  0  0  0  0            999 V2000
   -1.6179   -7.2342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -6.4474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6713   -6.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9193   -5.4819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7247   -5.3032    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2822   -5.9114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0876   -5.7328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0342   -6.6983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5916   -7.3065    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2287   -6.8769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3792   -7.6881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6404   -7.4552    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3619   -4.8737    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6099   -4.0868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4153   -3.9082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9727   -4.5164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7782   -4.3377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6633   -3.1214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1655   -2.4668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3951   -3.5022    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1059   -2.5132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3005   -2.6918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7430   -2.0836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9376   -2.2623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6896   -3.0491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2470   -3.6573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9990   -4.4441    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0525   -3.4787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1158   -3.2278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3638   -4.0146    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6732   -2.6196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4787   -2.7982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5146   -3.6224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1228   -4.1799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2383   -3.0748    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8603   -2.1541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1426   -1.3789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4685   -2.7115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2163   -2.3630    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2882   -1.5411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6125   -1.0678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6845   -0.2460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8626   -0.3178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4322    0.1026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5042    0.9245    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2520    1.2730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9277    0.7998    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6754    1.1483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3512    0.6751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7474    1.9702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4952    2.3188    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0717    2.4435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6551    3.0268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5986    3.1193    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3239    2.0949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6482    2.5682    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9005    2.2196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1080   -0.3707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8557   -0.0221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0360   -1.1925    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4710    0.5509    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.0545    1.1342    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.6742    0.7645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5044   -3.5358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9470   -4.1440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2956   -4.8917    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2796   -3.8180    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4228   -4.6305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9117   -3.2878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0361   -2.1900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7881   -1.4032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9827   -1.2245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4252   -1.8327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3802   -1.6541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6282   -0.8672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  3 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
  4 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 14 28  1  0  0  0  0
 22 28  4  0  0  0  0
 25 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 36 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 42 43  1  0  0  0  0
 42 44  1  0  0  0  0
 44 45  1  0  0  0  0
 45 46  1  0  0  0  0
 46 47  1  0  0  0  0
 47 48  1  0  0  0  0
 48 49  1  0  0  0  0
 48 50  1  0  0  0  0
 50 51  1  0  0  0  0
 50 52  1  0  0  0  0
 52 53  1  0  0  0  0
 52 54  1  0  0  0  0
 52 55  1  0  0  0  0
 46 55  1  0  0  0  0
 55 56  1  0  0  0  0
 56 57  1  0  0  0  0
 44 58  1  0  0  0  0
 58 59  1  0  0  0  0
 58 60  1  0  0  0  0
 40 60  1  0  0  0  0
 42 61  1  0  0  0  0
 61 62  1  0  0  0  0
 61 63  2  0  0  0  0
 38 64  1  0  0  0  0
 64 65  1  0  0  0  0
 34 65  1  0  0  0  0
 65 66  1  0  0  0  0
 64 67  1  0  0  0  0
 67 68  1  0  0  0  0
 67 69  1  0  0  0  0
 36 70  1  0  0  0  0
 32 70  4  0  0  0  0
 70 71  4  0  0  0  0
 71 72  4  0  0  0  0
 72 73  4  0  0  0  0
 31 73  4  0  0  0  0
 73 74  1  0  0  0  0
 24 74  1  0  0  0  0
 74 75  2  0  0  0  0
M  CHG  2  61   1  62  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4168

>  <JC_XSMILES>
COC1C(OC(C)C(O)C1(C)O)OC2C(OC)C(C)(O)CC3=CC4=C(C(O)=C23)C(=O)C5=C6OC7OC(C)(C(OC8CC(C)(C(OC9OC(C)C(O)C(C)(O)C9OC)C(C)O8)[N+]([O-])=O)C(C7O)N(C)C)C6=CC=C5C4=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1313

>  <W2 Pf proliferation inhibition EC50 uM>
0.0701

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.105263158

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4171
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599   -1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9849    0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 20 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 18 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4171

>  <JC_XSMILES>
CC(=O)C1=CC=CC(=C1)S(=O)(=O)NCCCNC2=NC3=CC(C)=CC(C)=C3C=C2C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
1.15

>  <W2 Pf proliferation inhibition EC50 uM>
0.698

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4173
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    3.2227    3.6495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6707    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9256    2.2518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498   -4.0609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  7 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
  5 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  CHG  1   7   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4173

>  <JC_XSMILES>
CC1=CC=C(C[N+]2=C3CCCN3C(=C2)C4=CC=C(C)C=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.538

>  <W2 Pf proliferation inhibition EC50 uM>
0.2398

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
34.5

>  <Powder data?>
Yes

>  <IFI value>
0.048780488

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4176
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.7771    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.0146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -4.2521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -3.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -3.0146    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -0.6205    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
 20 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
 33 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4176

>  <JC_XSMILES>
CC1=NC(N2CCN(CC2)C3=CC=CC=N3)=C4C(C)=C(SC4=N1)C(=O)NC5=C(F)C=CC=C5F

>  <PF proliferation inhibition 3D7 EC50 uM>
3.143

>  <W2 Pf proliferation inhibition EC50 uM>
0.694

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-418
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    5.6091   -3.3616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -2.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -2.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -3.3616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -4.1866    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7054   -4.6715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4505   -5.4562    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6255   -5.4562    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3706   -4.6715    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -0.8866    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.8630   -0.8866    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2130   -0.8866    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    1.5884    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    2.8259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669    4.0634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    2.8259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-418

>  <JC_XSMILES>
CC1=CC(=CC=C1N2C=NN=N2)S(=O)(=O)N3CCN(CC3)CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.732

>  <W2 Pf proliferation inhibition EC50 uM>
1.412

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.016129032

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4180
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  5 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  3 19  4  0  0  0  0
 14 19  4  0  0  0  0
  1 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4180

>  <JC_XSMILES>
C(NC1=NC(NC2=CC=CC=C2)=NC3=CC=CC=C13)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1579

>  <W2 Pf proliferation inhibition EC50 uM>
0.0934

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
13.49

>  <Powder data?>
Yes

>  <IFI value>
0.082089552

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4181
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  1  0  0  0  0
  9 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
 24 36  4  0  0  0  0
  6 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4181

>  <JC_XSMILES>
CCOC(=O)C1=CC=C(N2CCN(CC2)C3=CC(C)=CC=C3C)C(NC(=O)NC4=CC=C(Cl)C=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>3.54

>  <W2 Pf proliferation inhibition EC50 uM>
0.691

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4187
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    0.7097   -6.5063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8933   -5.7019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6816   -5.4587    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2885   -5.1408    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4720   -4.3365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1328   -3.7754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0507   -2.9711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8391   -2.7279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4439   -3.2890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2603   -4.0933    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0226   -1.9235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4178   -1.3624    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6014   -0.5581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0235    0.0426    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3897   -0.3149    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9945   -0.8760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7378   -0.5180    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4811   -0.8759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0858   -0.3148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8742   -0.5579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0578   -1.3622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4531   -1.9234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6647   -1.6802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1504   -2.3253    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.3254   -2.3253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9675   -3.0686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4322   -3.7503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0743   -4.4936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2516   -4.5553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7868   -3.8736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1448   -3.1303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8110   -1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 25 32  2  0  0  0  0
 11 32  1  0  0  0  0
 16 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4187

>  <JC_XSMILES>
CC(=O)NC1=CC=C(C=C1)C2NC(=O)NC3=NC4=CC=CC=C4SC(C5=CC=CC=C5)=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
1.022

>  <W2 Pf proliferation inhibition EC50 uM>
0.689

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4188
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    5.0645    1.4672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0025    2.4233    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4703   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1732   -2.7260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4281   -3.5106    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3662   -2.5545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1113   -1.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3043   -1.5983    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  6 14  4  0  0  0  0
  9 14  4  0  0  0  0
  7 15  1  0  0  0  0
 15 16  1  0  0  0  0
  4 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4188

>  <JC_XSMILES>
OC(=O)C1CC2=C(NC3=CC=CC=C23)C(N1)C4=CC=C(Cl)C=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
1.023

>  <W2 Pf proliferation inhibition EC50 uM>
0.688

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4190
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    1.8500    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223   -2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
 13 17  4  0  0  0  0
 11 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 18 25  4  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4190

>  <JC_XSMILES>
COC1=CC=C(CNC2=CC(=NC3=CC=NN23)C4=CC=C(F)C(F)=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.675

>  <W2 Pf proliferation inhibition EC50 uM>
0.687

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4191
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    2.8972    3.8750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.0808    3.0707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8691    2.8275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0527    2.0232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4479    1.4620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6596    1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4760    2.5095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6315    0.6577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4358    0.4742    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7938   -0.2691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4358   -1.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9502   -1.6575    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6315   -1.1960    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9865   -0.6816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -1.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5575   -0.6816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5575    0.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8431    0.5559    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.2720    0.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9865    0.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9502    1.1192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6488    1.8871    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7660    0.9962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2804    1.6412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0961    1.5183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6751    2.1060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4130    1.7369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2900    0.9211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4762    0.7860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
  8 20  1  0  0  0  0
 14 20  4  0  0  0  0
  9 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 25 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4191

>  <JC_XSMILES>
FC1=CC=C(C=C1)C2N(CC(=O)NC3=CC=C(Cl)C=C23)C(=O)CCC4CCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2308

>  <W2 Pf proliferation inhibition EC50 uM>
0.1804

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
26.27

>  <Powder data?>
Yes

>  <IFI value>
0.029411765

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4192
  Mrv1591402191617072D          

 13 14  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  2  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
  2 13  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  13
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4192

>  <JC_XSMILES>
CC1=C(Br)C(=O)C2=CC=CC=C2N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.532

>  <W2 Pf proliferation inhibition EC50 uM>
0.686

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4193
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    4.0431    7.2814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7076    8.0351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8871    8.1213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5515    8.8750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0364    9.5425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8569    9.4562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1925    8.7025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0130    8.6163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4979    9.2837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3184    9.1975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6539    8.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1690    7.7764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5046    7.0227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3250    6.9365    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8100    7.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6304    7.5177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9660    6.7640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4811    6.0966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6606    6.1828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1757    5.5154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5112    4.7617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0263    4.0943    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2813    3.3096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6138    2.8247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9464    3.3096    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2013    4.0943    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6138    1.9997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8993    1.5872    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3283    1.5872    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3283    0.7622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7408    0.0477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9158    0.0477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3485    7.8626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 22 26  4  0  0  0  0
 24 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 32  1  0  0  0  0
 12 33  4  0  0  0  0
  8 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4193

>  <JC_XSMILES>
CC1=CC=CC=C1C2=CC=CC(CN3CCCCC3CCN4C=C(N=N4)C(=O)NC5CC5)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.467

>  <W2 Pf proliferation inhibition EC50 uM>
0.685

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.019417476

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4196
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
    9.9292    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9292    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2148    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2148    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5003    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7858    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7858    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7858    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5003    4.8229    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    9.2148    4.4104    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    8.5003    5.6479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7858    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5003    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 22 23  1  0  0  0  0
 10 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 30 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  2  0  0  0  0
 25 36  4  0  0  0  0
  8 36  4  0  0  0  0
  6 37  4  0  0  0  0
 37 38  4  0  0  0  0
  3 38  4  0  0  0  0
M  CHG  2  33   1  34  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4196

>  <JC_XSMILES>
COC1=CC=C(NC2=NC(NN=CC3=CC4=C(OCO4)C=C3Br)=NC(NC5=CC=C(C=C5)[N+]([O-])=O)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.46

>  <W2 Pf proliferation inhibition EC50 uM>
0.684

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.064935065

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4198
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4198

>  <JC_XSMILES>
CNC1=CC=CC=C1C(=O)N(C)CCC2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.0683

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4199
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  5 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4199

>  <JC_XSMILES>
OC1=CC=C(C=C1CNC2CCN(CC2)CC3=CC=CC=C3)C4=CC=CC=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.411

>  <W2 Pf proliferation inhibition EC50 uM>
0.1432

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.03

>  <Powder data?>
Yes

>  <IFI value>
0.008547009

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-420
  Mrv1591402191617072D          

 20 23  0  0  0  0            999 V2000
    4.9920    1.2054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8204    2.0124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1530    3.1684    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5399    3.7205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9600    3.3400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3725    4.0544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1975    4.0544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6100    3.3400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1975    2.6255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3725    2.6255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  1  0  0  0  0
  6 11  4  0  0  0  0
  3 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-420

>  <JC_XSMILES>
CN1C(N(C)C2=CC=CC=C12)C3=CC=C4OCOC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.117

>  <W2 Pf proliferation inhibition EC50 uM>
>1.41

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.00621118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4203
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400   -4.0623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429   -5.4600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
  3 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 17 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
M  CHG  1  12   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4203

>  <JC_XSMILES>
CCC1=[N+](C)C2=CC=CC=C2N1CC(=O)OC3CC(C)CCC3C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2669

>  <W2 Pf proliferation inhibition EC50 uM>
0.2032

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
29.91

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4204
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 16 22  1  0  0  0  0
 14 23  4  0  0  0  0
  9 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4204

>  <JC_XSMILES>
COC1=CC=CC(=N1)C2=CC=C(O)C(CN3CCCC(C)C3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.543

>  <W2 Pf proliferation inhibition EC50 uM>
0.0679

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4205
  Mrv1591402191617072D          

 36 38  0  0  0  0            999 V2000
    4.6776    0.4189    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8758   -0.3820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2813   -0.9540    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4887   -0.7252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8942   -1.2973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1016   -1.0684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9034   -0.2676    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1108   -0.0388    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9126    0.7621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1200    0.9909    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5071    1.3341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3089    2.1350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9034    2.7070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7053    3.5078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9126    3.7367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0782    4.7663    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6726    4.1943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4653    4.4231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6634    5.2239    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0690    5.7960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2763    5.5672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6961    2.4782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8942    1.6773    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.2905    3.0502    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0832    2.8214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6776    3.3934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4703    3.1646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0648    3.7367    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8574    3.5078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4519    4.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8666    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4611    5.1095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2997    1.1053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4979    0.3044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2905    0.0756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 13 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  1  0  0  0  0
 32 33  1  0  0  0  0
 11 34  4  0  0  0  0
 34 35  4  0  0  0  0
  7 35  4  0  0  0  0
 35 36  4  0  0  0  0
  4 36  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4205

>  <JC_XSMILES>
CCOC1=CC=C2NC(=O)C(CN(CCCN3CCOCC3)C(=S)NCCCN(CC)CC)=CC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.611

>  <W2 Pf proliferation inhibition EC50 uM>
0.679

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.044247788

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4211
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
  6 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 15 14  1  4  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 25 26  1  0  0  0  0
M  CHG  2   9   1  10  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4211

>  <JC_XSMILES>
COC1=CC=C(C=C1[N+]([O-])=O)C(=O)ON=C(N)CC2=CC=C(Cl)C=C2Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
4.98

>  <W2 Pf proliferation inhibition EC50 uM>
0.675

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4213
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -9.4875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  2  8  4  0  0  0  0
  5  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4213

>  <JC_XSMILES>
FC1=CC=C(C(Cl)=C1)C(=O)N2CCN(CC2)C3=CC=C(C=C3)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1548

>  <W2 Pf proliferation inhibition EC50 uM>
0.0675

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.042553191

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4214
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
  6 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4214

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C(C)=CC(C)=CC2=C1NC3=CC=C(C=C3)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.749

>  <W2 Pf proliferation inhibition EC50 uM>
0.675

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4216
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    5.3501   -2.4848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1602   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7003   -2.0171    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9703   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5104   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0505   -1.5493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8606   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4007   -1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1307   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2109   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7510   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4809    0.1657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0210    0.7893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8311    0.6334    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1012   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9113   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1814   -1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9915   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   12.6413   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8311   -1.5493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5611   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 16 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4216

>  <JC_XSMILES>
CCN(CC)CCCC(C)NC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.002426

>  <W2 Pf proliferation inhibition EC50 uM>
0.0837

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.42

>  <Powder data?>
Yes

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4217
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    3.9942   -4.1467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9942   -4.9717    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3267   -5.4566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5817   -6.2413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4067   -6.2413    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6616   -5.4566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4462   -5.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6177   -4.3947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4024   -4.1398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0155   -4.6918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8439   -5.4988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0593   -5.7537    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8878   -6.5607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1032   -6.8156    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5009   -7.1127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3078   -6.9412    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7203   -7.6557    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1683   -8.2688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3398   -9.0757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1245   -9.3307    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2960  -10.1377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0806  -10.3926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2521  -11.1996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6390  -11.7516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8106  -12.5586    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.8544  -11.4967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6829  -10.6897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8983  -10.4348    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4146   -7.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 27 28  1  0  0  0  0
 18 29  4  0  0  0  0
 15 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4217

>  <JC_XSMILES>
CN1C=CN=C1C2CCCCN2C(=O)C3=NOC(COC4=CC=C(F)C=C4Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.832

>  <W2 Pf proliferation inhibition EC50 uM>
0.673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4218
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -3.8121   -3.0176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9916   -3.1038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5067   -2.4364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6862   -2.5226    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1342   -1.9095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3805   -2.2451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3340   -1.8326    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.0484   -2.2451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7629   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7629   -1.0076    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4774   -2.2451    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1918   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9063   -2.2451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6600   -1.9095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2120   -2.5226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7995   -3.2371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9926   -3.0655    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4667   -3.0655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0853   -3.6786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1696   -4.4633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9766   -4.6348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5287   -4.0217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2737   -3.2371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
  6 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  4 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4218

>  <JC_XSMILES>
CCCN1C=C(SCC(=O)NCC2=CC=CO2)C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
1.024

>  <W2 Pf proliferation inhibition EC50 uM>
0.673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011494253

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4219
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
   -2.6462   -3.5558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -4.2703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -7.1282    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7231   -7.8819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3362   -8.4339    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0507   -8.0214    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8792   -7.2144    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
  2 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 22 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4219

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)N2C=NN=N2)C3CCN(CC3)CC4=CC5=CC=CC=C5O4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.198

>  <W2 Pf proliferation inhibition EC50 uM>
0.416

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>61.89

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-422
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
  5 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 36 37  4  0  0  0  0
  3 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-422

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=C(Cl)C=C2)C(=O)NC3=CC=C(Br)C=C3)=C4N=CC=CC4=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.788

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>5.6

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4221
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4694   -6.1106    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0215   -5.4975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6090   -4.7830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8020   -4.9545    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1839   -5.8519    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7359   -6.4650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3234   -7.1795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5165   -7.0080    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  1  0  0  0  0
  2 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 28 30  1  0  0  0  0
 30 31  2  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 30 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4221

>  <JC_XSMILES>
O=C(NCCCCNC(=O)NC1=CC=CC(=C1)C2=NCCN2)NC3=CC=CC(=C3)C4=NCCN4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2029

>  <W2 Pf proliferation inhibition EC50 uM>
0.0672

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009009009

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4224
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  5 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4224

>  <JC_XSMILES>
OC1=CC=C(C=C1CNC2CCN(CC2)CC3=CC=CC=C3)C4=CN=CN=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.698

>  <W2 Pf proliferation inhibition EC50 uM>
0.671

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.01010101

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4230
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 10 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  2  0  0  0  0
 22 33  4  0  0  0  0
  8 33  4  0  0  0  0
M  CHG  2  30   1  31  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4230

>  <JC_XSMILES>
CN1CCN(CC1)C2=NC(NN=CC3=CC=CC(Cl)=C3)=NC(NC4=CC=C(C=C4)[N+]([O-])=O)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.29

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
43.37

>  <Powder data?>
Yes

>  <IFI value>
0.051948052

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4236
  Mrv1591402191617072D          

 32 33  0  0  0  0            999 V2000
    6.3126   -2.3197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4930   -2.2251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1817   -2.7929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6900   -3.4553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3291   -3.6446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1487   -3.7392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4765   -4.4963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2960   -4.5909    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6239   -5.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1321   -6.0104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4600   -6.7675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9682   -7.4299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2960   -8.1870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8043   -8.8494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1321   -9.6065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6404  -10.2690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9848   -8.7548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6569   -7.9977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1487   -7.3353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8209   -6.5782    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3126   -5.9158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9848   -5.1587    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7878   -3.9285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4600   -3.1714    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.6073   -4.0231    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0991   -3.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9186   -3.4553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4104   -2.7929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2299   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.7216   -2.2251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5577   -3.6446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 13 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  2  0  0  0  0
  9 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4236

>  <JC_XSMILES>
CCN(CC)CCCN(CC1=CC2=CC(CC)=CC=C2NC1=O)C(=S)NCCCN(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
2.039

>  <W2 Pf proliferation inhibition EC50 uM>
0.664

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027272727

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4241
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400   -4.0623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0470   -4.2338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5990   -3.6207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3441   -2.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8961   -2.2230    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  3  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4241

>  <JC_XSMILES>
CC1=C(C=O)C2=CC=CC=C2N1CC(=O)NC3=CC=CC(I)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.365

>  <W2 Pf proliferation inhibition EC50 uM>
0.405

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>61.22

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4243
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
  7 24  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4243

>  <JC_XSMILES>
FC1=CC=C(NC2=NC(NCC3=CC=CC=C3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0755

>  <W2 Pf proliferation inhibition EC50 uM>
0.0586

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.87

>  <Powder data?>
Yes

>  <IFI value>
0.095238095

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4245
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 18 27  4  0  0  0  0
 27 28  4  0  0  0  0
 15 28  4  0  0  0  0
 13 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 12 33  1  0  0  0  0
 32 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4245

>  <JC_XSMILES>
CC(C)COC(=O)C1=C(C)NC2=C(C1C3=CC=C(OCC4=CC=CC=C4)C=C3)C(=O)CC(C2)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.961

>  <W2 Pf proliferation inhibition EC50 uM>
0.659

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4246
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
  7 21  4  0  0  0  0
 21 22  4  0  0  0  0
  4 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4246

>  <JC_XSMILES>
CCOC1=CC=C(CCNC(=O)NC2=CC=C(F)C=C2)C=C1OCC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.751

>  <W2 Pf proliferation inhibition EC50 uM>
0.492

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>74.74

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4251
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    6.9309   -2.2185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1773   -1.8829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5098   -2.3678    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5098   -3.1928    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -3.4478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2403   -2.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4703   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 14 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4251

>  <JC_XSMILES>
CCN1CCCC1CNC2=NC=NC3=C2NC4=CC=C(C)C=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2692

>  <W2 Pf proliferation inhibition EC50 uM>
0.1377

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.01

>  <Powder data?>
Yes

>  <IFI value>
0.08

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4253
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -3.0932   -3.6193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3788   -4.0318    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3788   -4.8568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6643   -3.6193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9498   -4.0318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2353   -3.6193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4791   -4.0318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4791   -4.8568    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1936   -3.6193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9473   -3.9549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4993   -3.3418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0868   -2.6273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2798   -2.7988    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6388   -2.0142    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4673   -1.2072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3925   -2.3498    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3063   -3.1702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9194   -3.7223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7040   -3.4673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3171   -4.0194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1456   -4.8263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7587   -5.3784    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.3609   -5.0813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7478   -4.5292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4253

>  <JC_XSMILES>
CN(C)CCNC(=O)C1=CC2=C(S1)N(C)N=C2C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.339

>  <W2 Pf proliferation inhibition EC50 uM>
0.422

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
64.58

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4256
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4256

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C(Cl)Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02858

>  <W2 Pf proliferation inhibition EC50 uM>
0.0914

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>14.05

>  <Powder data?>
No

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4258
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
  9 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 16 24  4  0  0  0  0
 14 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 13 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4258

>  <JC_XSMILES>
CCCCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(OC)C(Br)=C3)C(=O)CCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.615

>  <W2 Pf proliferation inhibition EC50 uM>
0.65

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022222222

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-426
  Mrv1591402191617072D          

 19 19  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 12 19  4  0  0  0  0
  4 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-426

>  <JC_XSMILES>
CCNC1=NC(NC(C)C)=NC(NC(N)NOC)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.153

>  <W2 Pf proliferation inhibition EC50 uM>
>1.4

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4260
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2960   -0.1085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8653    0.4014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6499    0.6563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8214    1.4633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2083    2.0153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4237    1.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2522    0.9534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0968   -3.8419    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.9445   -3.6594    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2793   -2.6896    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  5 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
  4 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4260

>  <JC_XSMILES>
CN1N=C(C(=C1NC(=O)NC2=CC=CC=C2)C3=CC=C(F)C=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.392

>  <W2 Pf proliferation inhibition EC50 uM>
0.353

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
54.32

>  <Powder data?>
Yes

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4261
  Mrv1591402191617072D          

 43 47  0  0  0  0            999 V2000
    0.5942    2.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0422    2.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2971    1.3977    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2549    0.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0619    0.9561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7224   -1.3819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5474   -1.3819    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -2.0964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -2.0964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7224   -2.8109    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -3.5253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4894   -3.6116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3179   -4.4185    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0324   -4.8310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1186   -5.6515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8723   -5.9871    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9585   -6.8075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2911   -7.2925    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7122   -7.1431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8837   -7.9501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7042   -8.0363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0398   -7.2826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4267   -6.7306    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6455   -4.2790    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4525   -4.4505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7074   -5.2351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5144   -5.4067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0664   -4.7936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8115   -4.0090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0045   -3.8374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3635   -3.3959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9155   -2.7828    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7504   -2.8438    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9766   -3.9479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3349    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 22 26  4  0  0  0  0
 17 27  4  0  0  0  0
 14 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 34 37  1  0  0  0  0
  7 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
  6 40  4  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 42 43  1  0  0  0  0
 39 43  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4261

>  <JC_XSMILES>
CCOC(=O)C1=C(NC(=O)C(C)SC2=NN=C(CNC(=O)C3=CC=CO3)N2C4=CC=CC(=C4)C(F)(F)F)SC5=C1CCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.649

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.025

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4265
  Mrv1591402191617072D          

 16 18  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  2  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
  5 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4265

>  <JC_XSMILES>
ClC1=CC=C2C(=O)C3=C(CCCC3)NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.333

>  <W2 Pf proliferation inhibition EC50 uM>
0.649

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4266
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    1.4002   -4.3408    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1146   -4.7533    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1146   -5.5783    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8291   -4.3408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5436   -4.7533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2581   -4.3408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2581   -3.5158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5436   -3.1033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8291   -3.5158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1146   -3.1033    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1146   -2.2783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8291   -1.8658    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4002   -1.8658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5752   -1.8658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9877   -1.1514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4303   -0.5431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3751   -0.7216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9325   -0.1133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6843    0.6734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1211    0.8520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6784    0.2437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5451   -0.5431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2969    0.2437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8543    0.8519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6598    0.6734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9078   -0.1134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3504   -0.7217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4266

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC=C1NC(=O)C2CC2(C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.647

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4268
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
  4 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 16 27  4  0  0  0  0
  2 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  2  0  0  0  0
M  CHG  6  12   1  13  -1  24   1  25  -1  28   1  29  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4268

>  <JC_XSMILES>
CC1=NC(NC2=CC=CC(=C2)[N+]([O-])=O)=NC(NC3=CC=CC(=C3)[N+]([O-])=O)=C1[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
6.75

>  <W2 Pf proliferation inhibition EC50 uM>
0.645

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4269
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2552    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4269

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3CC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1636

>  <W2 Pf proliferation inhibition EC50 uM>
0.0467

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>7.25

>  <Powder data?>
No

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4270
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
  8 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 20 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 18 29  4  0  0  0  0
 29 30  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  28
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4270

>  <JC_XSMILES>
COCCNC(=S)N(CC1=CC=C(F)C=C1)CC2=CC3=CC=C(C)C(C)=C3NC2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.412

>  <W2 Pf proliferation inhibition EC50 uM>
0.0642

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.025

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4273
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175   -4.4158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483   -3.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878   -3.3762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489   -2.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227   -3.3151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    4.3034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4788    5.0178    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7808    3.8909    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.3518    4.7159    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 13 18  4  0  0  0  0
 11 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 31 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 34 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4273

>  <JC_XSMILES>
CC(C)(C)CC(C)(C)NC1=C(N=C2C=CC=CN12)C3=CC=CC=C3OC(=O)C4=CC=C(C=C4)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.67

>  <W2 Pf proliferation inhibition EC50 uM>
0.064

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.038095238

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4274
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 12 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
 11 29  1  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4274

>  <JC_XSMILES>
CC(C)OC(=O)C1=C(C)NC2=C(C1C3=CC=C(C=C3)[N+]([O-])=O)C(=O)CC(C)(C)C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.565

>  <W2 Pf proliferation inhibition EC50 uM>
0.2554

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
39.98

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4281
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
   -0.3705   -1.6055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4178   -1.3623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6014   -0.5580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3897   -0.3148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9945   -0.8760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7378   -0.5180    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4811   -0.8760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6647   -1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1503   -2.3253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3253   -2.3253    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8109   -1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0226   -1.9235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5083   -3.0686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3309   -3.1303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6889   -3.8736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2242   -4.5552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5821   -5.2985    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4015   -4.4935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0435   -3.7502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4530   -1.9235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6366   -2.7278    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0578   -1.3623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8742   -0.5580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0859   -0.3148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4790    0.0031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2954    0.8075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9002    1.3686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6885    1.1254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8721    0.3211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2673   -0.2400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  5 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
  9 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
  8 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  7 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4281

>  <JC_XSMILES>
CC1=CC=C2NC3=C(C(NC2=C1)C4=CC=C(F)C=C4)C(=O)CC(C3)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.833

>  <W2 Pf proliferation inhibition EC50 uM>
0.635

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4282
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 10 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 31 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  2  0  0  0  0
 26 37  4  0  0  0  0
  8 37  4  0  0  0  0
  6 38  4  0  0  0  0
 38 39  4  0  0  0  0
  3 39  4  0  0  0  0
M  CHG  4  22   1  23  -1  34   1  35  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4282

>  <JC_XSMILES>
COC1=CC=C(NC2=NC(NN=CC3=CC=CC(=C3OC)[N+]([O-])=O)=NC(NC4=CC=C(C=C4)[N+]([O-])=O)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2209

>  <W2 Pf proliferation inhibition EC50 uM>
0.635

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.064935065

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4285
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -2.1434    4.5375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.9500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.4289    5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 12 26  4  0  0  0  0
 21 26  4  0  0  0  0
  7 27  4  0  0  0  0
 27 28  4  0  0  0  0
  4 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4285

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(NC(=O)CN2C3=CC=CC=C3C(=O)C4=CC=CC=C24)C=C1Br

>  <PF proliferation inhibition 3D7 EC50 uM>
1.108

>  <W2 Pf proliferation inhibition EC50 uM>
0.632

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4286
  Mrv1591402191617072D          

 49 55  0  0  0  0            999 V2000
   -2.7512    3.1152    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    3.1152    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5127   -0.6697    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7676   -1.4544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5926   -1.4544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8476   -0.6697    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    4.3527    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    5.5902    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    6.8277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0772    8.1421    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6292    8.7552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2167    9.4697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4098    9.2982    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380    4.7652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    3.5277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4669    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4669    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.1814    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2677    1.0572    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0746    0.8857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.4871    1.6001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.9351    2.2132    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
  2 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 28 31  1  0  0  0  0
 31 32  2  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 31 35  1  0  0  0  0
 18 36  1  0  0  0  0
 36 37  2  0  0  0  0
 36 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 39 44  4  0  0  0  0
 42 45  1  0  0  0  0
 45 46  2  0  0  0  0
 46 47  1  0  0  0  0
 47 48  1  0  0  0  0
 48 49  1  0  0  0  0
 45 49  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4286

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)C2=NCCN2)NC3=CC(=CC=C3C(=O)NC4=CC=C(C=C4)C5=NCCN5)C(=O)NC6=CC=C(C=C6)C7=NCCN7

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0997

>  <W2 Pf proliferation inhibition EC50 uM>
0.0629

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018018018

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4291
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    5.8293    1.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0223    1.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2243   -1.1567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.7556    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1544    1.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1347   -1.5983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6867   -2.2114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4937   -2.0399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7486   -1.2553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1966   -0.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  4  0  0  0  0
 11 19  4  0  0  0  0
 15 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4291

>  <JC_XSMILES>
CCCN1CCC2=C(C1)SC3=C2C(=O)N(C(SC)=N3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.947

>  <W2 Pf proliferation inhibition EC50 uM>
0.627

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.115384615

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4295
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    1.4401   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1546   -5.5690    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1546   -4.7440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8690   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5835   -5.5690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2980   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0125   -5.5690    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7269   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7269   -6.8065    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4414   -7.2190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1559   -6.8065    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1559   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4414   -5.5690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6129   -4.7621    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4334   -4.6758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9183   -4.0084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7388   -4.0946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0744   -4.8483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8948   -4.9346    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.5894   -5.5158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7690   -5.4295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4295

>  <JC_XSMILES>
CN(C)CCCNC1=NC=NC2=C1NC3=CC=C(F)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0931

>  <W2 Pf proliferation inhibition EC50 uM>
0.3048

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.71

>  <Powder data?>
Yes

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4296
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
  4 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4296

>  <JC_XSMILES>
CC(C)N(C1CCN(CC1)C(C)=O)C(=O)NC2=C(F)C=CC=C2F

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.625

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4297
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  3  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  5 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 12 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
 20 29  4  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4297

>  <JC_XSMILES>
COC1=CC(=CC(Br)=C1OC)C(NC2=CC=CC=N2)C3=CC=C4C=CC=NC4=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.368

>  <W2 Pf proliferation inhibition EC50 uM>
0.2188

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>35.02

>  <Powder data?>
Yes

>  <IFI value>
0.12962963

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-430
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -1.8021    0.6464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8021    1.4714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5166    1.8839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2311    1.4714    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.5166    2.7089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8021    3.1214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0877    2.7089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0877    1.8839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3732    1.4714    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3732    0.6464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0877    0.2339    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4540    0.2037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4540   -0.6213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0557   -1.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7702   -0.5911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7702    0.2339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0557    0.6464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8495   -0.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1350   -0.5911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1350    0.2339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3732   -1.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3732   -1.8286    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0877   -0.5911    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 20  1  0  0  0  0
 13 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-430

>  <JC_XSMILES>
CC1=C(Cl)C=CC=C1NC(=O)C2C(C3C=CC2C34CC4)C(O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.251

>  <W2 Pf proliferation inhibition EC50 uM>
1.398

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4302
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -9.1855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414  -10.6145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
  5 24  4  0  0  0  0
 24 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4302

>  <JC_XSMILES>
OC1=CC=C(NC(=O)C2=CC=CC(=C2)S(=O)(=O)N3CCCCC3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
6.91

>  <W2 Pf proliferation inhibition EC50 uM>
0.621

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4304
  Mrv1591402191617072D          

 34 37  0  0  1  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4647   -4.0640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3199   -4.3189    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4915   -5.1259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1216   -5.6779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9063   -5.4230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0778   -4.6160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0339   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8186   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9901   -2.4922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3770   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5924   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -4.3257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4824   -3.5721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6318   -4.9932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4522   -4.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9372   -5.5744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6016   -6.3281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0865   -6.9955    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9070   -6.9093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7811   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2962   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  5  3  1  6  0  0  0
  5  6  1  0  0  0  0
  7  6  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 11 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  7 24  1  1  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  4  0  0  0  0
 27 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4304

>  <JC_XSMILES>
COC(=O)[C@@H]1C[C@H](CN1CC(C2=CC=CC=C2)C3=CC=CC=C3)NC(=O)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.148

>  <W2 Pf proliferation inhibition EC50 uM>
<0.02574

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>4.17

>  <Powder data?>
No

>  <IFI value>
0.016528926

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4305
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    7.0685    4.3282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2560    4.1850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7257    4.8169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0079    5.5922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4776    6.2242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9133    4.6737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6311    3.8984    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1614    3.2664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8792    2.4912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3489    1.5727    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5365    2.9799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8186    3.7552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.8085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 19 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  4  0  0  0  0
 26 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4305

>  <JC_XSMILES>
CCC(CC)CN1CCC(O)(CC1)C2=CC=C3OC(=CC3=C2)C(=O)NC4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.954

>  <W2 Pf proliferation inhibition EC50 uM>
0.617

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.016949153

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4311
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    6.4835    5.4256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6187    4.6117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3910    4.3218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0796    4.7763    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7246    4.2619    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4347    3.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8892    2.8010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6105    3.5266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0961    2.8815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3976    2.1136    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2804    3.0045    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7660    2.3595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9502    2.4825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4358    1.8374    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7938    1.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4358    0.3508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6315    0.1673    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9865    0.6816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720    0.2691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5575    0.6816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5575    1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720    1.9191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9865    1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6315    2.0210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9502   -0.2942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7744   -0.2571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0642   -1.0295    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.4192   -1.5439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7307   -1.0894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 14 24  1  0  0  0  0
 16 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4311

>  <JC_XSMILES>
CCC1=NOC(C)=C1C(=O)NCCN2CC(OC3=CC=CC=C3C2)C4=CSC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.827

>  <W2 Pf proliferation inhibition EC50 uM>
0.615

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4313
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0470   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -4.9820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1830   -5.6495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -4.9820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3819   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1665   -3.9425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 11 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 10 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
 38 39  1  0  0  0  0
 30 39  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4313

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)N(C(C(=O)NC2CCCCC2)C3=CN(C)N=C3C)C(=O)C4COC5=CC=CC=C5O4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.443

>  <W2 Pf proliferation inhibition EC50 uM>
0.614

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.017094017

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4314
  Mrv1591402191617072D          

 44 46  0  0  0  0            999 V2000
   -0.1105   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -4.6480    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -3.9336    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895   -3.9336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6645   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0770   -6.0770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9020   -6.0770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3145   -6.7914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9020   -7.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0770   -7.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6645   -6.7914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395   -6.7914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395   -7.6164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395   -5.9664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145   -6.7914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -6.0770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3145   -8.2204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0289   -7.8079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6000   -8.6329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7270   -8.9349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3145   -9.6493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -3.2191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -3.2191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.9336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -3.9336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5230   -3.2191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480   -3.2191    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7605   -2.5046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -2.5046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5230   -1.7901    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480   -1.7901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7605   -1.0757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5855   -1.0757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9980   -0.3612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5855    0.3533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7605    0.3533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480   -0.3612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.5046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 15 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
  6 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 38 43  4  0  0  0  0
 35 44  4  0  0  0  0
 29 44  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4314

>  <JC_XSMILES>
CCNC(=O)N(CCCCOC1=CC=C(C=C1C(C)(C)CC)C(C)(C)CC)CC2=CC=C(OC)C(OCC3=CC=CC=C3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.595

>  <W2 Pf proliferation inhibition EC50 uM>
0.061

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009433962

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4317
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -5.8070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5695    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3320    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0945    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3320   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2695    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0395   -1.0396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5082    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0395    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 21  1  0  0  0  0
 13 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 22  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4317

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)N2C(=O)C3C4CC(C(Br)C4Br)C3C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.441

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>72.49

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-432
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -1.5356    5.5902    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041    3.0428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492    2.2581    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693    3.0428    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4886    7.3126    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2337    8.0972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4087    8.0972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1537    7.3126    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
  2 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-432

>  <JC_XSMILES>
O=C(C1CCN(CC1)C(=O)C2=CSC=N2)C3=NC=CS3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.39

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4320
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -4.1974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -4.9820    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
  9 18  4  0  0  0  0
  5 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  7 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4320

>  <JC_XSMILES>
ClC1=CC=C2N=C(C=C(C(=O)NC3=NOC=C3)C2=C1)C4=CC=CN=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.501

>  <W2 Pf proliferation inhibition EC50 uM>
0.606

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4322
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    2.0367   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    2.4134    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8476   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -3.0215    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -2.5366    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -1.2991    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
  7 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
  5 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
 18 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4322

>  <JC_XSMILES>
COC(=O)C1=CN(CC2=CC=C(OC)C=C2)C=C(C1C3=CC=CS3)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
5.64

>  <W2 Pf proliferation inhibition EC50 uM>
0.602

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.025

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4323
  Mrv1591402191617072D          

 41 46  0  0  0  0            999 V2000
   -3.1627   -7.3562    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1627   -8.1812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4482   -8.5937    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4482   -9.4187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7808   -9.9036    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0357  -10.6882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8607  -10.6882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1156   -9.9036    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5508  -11.3557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7303  -11.2694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2454  -11.9369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5809  -12.6905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4014  -12.7768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8863  -12.1093    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8771   -8.5937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8771   -9.4187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5916   -9.8312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3061   -9.4187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0206   -9.8312    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7350   -9.4187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4495   -9.8312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1640   -9.4187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1640   -8.5937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4495   -8.1812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7350   -8.5937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8784   -8.1812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8784   -7.3562    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -9.5929   -8.5937    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.3074   -8.1812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.0611   -8.5167    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -11.6131   -7.9036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.2006   -7.1892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.3936   -7.3607    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  -12.4336   -7.9899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.7691   -8.7435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -13.5896   -8.8298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -14.0745   -8.1623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -13.7390   -7.4087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.9185   -7.3224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3061   -8.5937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5916   -8.1812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  2 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 23 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 29 33  4  0  0  0  0
 31 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 18 40  4  0  0  0  0
 40 41  4  0  0  0  0
 15 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4323

>  <JC_XSMILES>
O=C(NC1=NC(=CS1)C2=CC=CC=N2)C3=CC=C(OC4=CC=C(C=C4)C(=O)NC5=NC(=CS5)C6=CC=CC=N6)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.235

>  <W2 Pf proliferation inhibition EC50 uM>
0.602

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.126436782

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4326
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7615   -5.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0964   -5.4349    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
  4 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  3  0  0  0  0
 16 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
 19 25  4  0  0  0  0
  2 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4326

>  <JC_XSMILES>
NC1=NC(SCC(=O)C2=CC=C(Cl)C=C2)=C(C#N)C(C3=CC=CO3)=C1C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
2.284

>  <W2 Pf proliferation inhibition EC50 uM>
0.595

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.007142857

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4328
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    4.8229    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 10 19  4  0  0  0  0
  2 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4328

>  <JC_XSMILES>
CC1=NC2=NC(C)=NN2C(NC3=CC=C(Br)C=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.728

>  <W2 Pf proliferation inhibition EC50 uM>
0.595

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.019607843

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4333
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    1.4289   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1904   -0.3401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    0.4445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    0.4445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5253   -0.3401    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
  7 12  4  0  0  0  0
  3 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 13 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4333

>  <JC_XSMILES>
OC1=C(C=C(Cl)C2=CC=CN=C12)C(NC(=O)COC3=CC=CC=C3)C4=CC=CO4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.491

>  <W2 Pf proliferation inhibition EC50 uM>
0.589

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4335
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175   -4.4158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483   -3.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878   -3.3762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489   -2.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227   -3.3151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    1.4455    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 13 18  4  0  0  0  0
 11 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 33 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4335

>  <JC_XSMILES>
CC(C)(C)CC(C)(C)NC1=C(N=C2C=CC=CN12)C3=CC=CC=C3OC(=O)C4=CC=CC=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.822

>  <W2 Pf proliferation inhibition EC50 uM>
0.0588

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.047169811

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-434
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    3.0919   -4.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4243    0.3820    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3895    0.7555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8343    1.3656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0282    1.1899    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0850    2.1516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5298    2.7617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7805    3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5866    3.7235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1419    3.1133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8911    2.3274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 10 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  7 26  1  0  0  0  0
 21 26  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-434

>  <JC_XSMILES>
CC1=CC=C(CN2C(=O)C(O)(CC(=O)C3=CC=CC=C3)C4=CC=CC=C24)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
7.01

>  <W2 Pf proliferation inhibition EC50 uM>
8.96

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>64.52

>  <Powder data?>
Yes

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4340
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  2  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 14 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 10 25  4  0  0  0  0
  4 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4340

>  <JC_XSMILES>
CCNC1=NC(OC)=NC(OC2=NN(C(=O)C=C2)C3=CC=CC=C3)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.548

>  <W2 Pf proliferation inhibition EC50 uM>
0.584

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4343
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 10 16  4  0  0  0  0
  5 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
  4 25  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4343

>  <JC_XSMILES>
CN(C)C1=C(N(C(C)=O)C2=CC=CC(O)=C2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0467

>  <W2 Pf proliferation inhibition EC50 uM>
0.0582

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4344
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
  7 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4344

>  <JC_XSMILES>
CCOC1=CC=C(C=C1Cl)C2C(=CNC=C2C(=O)OC)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3039

>  <W2 Pf proliferation inhibition EC50 uM>
0.581

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4346
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -5.6206   -0.8623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9061   -0.4498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1916   -0.8623    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4772   -0.4498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4772    0.3752    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7627   -0.8623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0482   -0.4498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3338   -0.8623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3338   -1.6873    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0482   -2.0998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7627   -1.6873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6193   -2.0998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0952   -1.6873    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6193   -2.9248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3338   -3.3373    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0952   -3.3373    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8097   -2.9248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8097   -2.0998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5241   -1.6873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2386   -2.0998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9531   -1.6873    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6675   -2.0998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3125   -1.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1169   -1.7690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4748   -2.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1169   -3.2556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3125   -3.4391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6675   -2.9248    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9531   -3.3373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9531   -4.1623    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2386   -2.9248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5241   -3.3373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 22 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  2  0  0  0  0
 29 31  4  0  0  0  0
 20 31  4  0  0  0  0
 31 32  4  0  0  0  0
 17 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4346

>  <JC_XSMILES>
CCOC(=O)C1CCN(CC1)C(=O)C(=O)NC2=CC=C3N=C4CCCCCN4C(=O)C3=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.998

>  <W2 Pf proliferation inhibition EC50 uM>
0.58

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4348
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.0694    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1544   -0.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9614   -0.8867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2163   -1.6713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5134   -0.2736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2243    1.9817    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 13 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
  7 22  4  0  0  0  0
 11 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4348

>  <JC_XSMILES>
CCCN1CCC2=C(C1)SC3=NC(SCC(C)=C)=NC(N)=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.799

>  <W2 Pf proliferation inhibition EC50 uM>
0.383

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>66.32

>  <Powder data?>
Yes

>  <IFI value>
0.14

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4350
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.9519    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    5.8098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    6.5242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    5.6479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    4.8229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  4  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
 14 26  4  0  0  0  0
 12 27  4  0  0  0  0
 27 28  2  0  0  0  0
 27 29  4  0  0  0  0
 10 29  4  0  0  0  0
 29 30  1  0  0  0  0
  6 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 34 37  4  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 37 40  4  0  0  0  0
 31 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4350

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N=c2sc(=CC3=CC(Br)=C(OCC=C)C(OC)=C3)c(=O)n2C1C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.576

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.01459854

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4351
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    2.9646    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9646    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2501    2.0009    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2501    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9646    0.7634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5356    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5356   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8212   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8212    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0597   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1953   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0203   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2752   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0598   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6729   -2.0811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5014   -2.8881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1145   -3.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8991   -3.1852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5122   -3.7372    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -4.0706   -2.3782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4575   -1.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6291   -1.0192    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.2897   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7746   -3.9035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3778   -3.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9571   -2.7512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 26 27  1  0  0  0  0
 16 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 28 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4351

>  <JC_XSMILES>
CCOC(=O)C1CCN(CC1)C(=O)C2=CC(=NN2CC3=CC=C(Cl)C=C3Cl)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.34

>  <W2 Pf proliferation inhibition EC50 uM>
0.576

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.016260163

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4354
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    3.7778    3.7927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5615    3.5349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1766    4.0847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9603    3.8269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1289    3.0193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5138    2.4695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7301    2.7273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6824    1.6619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4832    1.4634    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.8273    0.7136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6509    0.7600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1029    0.0698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7312   -0.6667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9076   -0.7131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4556   -0.0229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6480   -0.1915    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0126    0.3348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0279    1.1596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2482    1.4291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0079    2.2183    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7510    0.7708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9290    0.6998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5795   -0.0475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0520   -0.7239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8739   -0.6529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2234    0.0944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
  8 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 17 26  1  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4354

>  <JC_XSMILES>
CC1=CC=CC(=C1)C2SC3=CC=CC=C3N=C4C2C(=O)C5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2996

>  <W2 Pf proliferation inhibition EC50 uM>
0.14

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
24.43

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4355
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4710   -5.5020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1354   -6.2557    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3149   -6.1695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7629   -6.7826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9424   -6.6963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6069   -7.4500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2200   -8.0020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9344   -7.5895    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
  2 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
 20 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4355

>  <JC_XSMILES>
O=C(CSC1=NN2C(C=C1)=NN=C2C3=CC=CS3)NC4=CC=C5OCCOC5=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.447

>  <W2 Pf proliferation inhibition EC50 uM>
0.573

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4356
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    4.0716    1.5745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2470    1.5487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8124    2.2499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    2.2242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5978    1.4972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0325    0.7959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8571    0.8217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2917    0.1205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7732    1.4714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3386    2.1727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4626    1.9760    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5232    1.1532    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.2406    0.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4373    0.0402    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7286    2.8997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0551    3.1575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8464    3.7162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5532    2.9254    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9432    3.6524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5086    4.3537    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7678    3.6782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1578    4.4052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9824    4.4310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4170    3.7297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0270    3.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2024    2.9770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  2  0  0  0  0
 10 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
  4 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4356

>  <JC_XSMILES>
CC1=CC2=C(C=C1C)c3c(ssc3=S)C(C)(C)N2C(=O)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.6

>  <W2 Pf proliferation inhibition EC50 uM>
0.572

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4358
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4358

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Cl)C=C3)C(=O)CC(C2)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2935

>  <W2 Pf proliferation inhibition EC50 uM>
0.398

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>69.81

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4359
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    5.1170    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8315    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5459    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2604    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9749    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9749    1.3607    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6894    0.1232    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.4038    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4038    1.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1183    1.7732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8328    1.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8328    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1183    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1183   -0.7018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7857   -1.1867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5704   -0.9317    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1835   -1.4838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6314   -2.0969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7355   -0.8707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7966   -2.0358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5812   -1.7809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3658   -1.5259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.8361   -2.5655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3262   -0.9963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5308   -1.9713    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.9433   -2.6858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5308   -3.4003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7058   -3.4003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2933   -4.1147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2933   -2.6858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7058   -1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4509   -1.1867    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 15 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
 31 32  4  0  0  0  0
 14 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4359

>  <JC_XSMILES>
CCCCC(=O)OC1=CC=CC=C1C2=C(NC(C)(C)CC(C)(C)C)N3C=CC(C)=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.854

>  <W2 Pf proliferation inhibition EC50 uM>
0.057

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.046728972

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-436
  Mrv1591402191617072D          

 15 16  0  0  0  0            999 V2000
    4.8950    0.0996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2500    0.6140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3729    1.4298    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7279    1.9441    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
    4.3729    2.4585    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700    1.2008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656    1.0173    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206    1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062    1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917    1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917    2.3566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062    2.7691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206    2.3566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656    2.8710    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700    2.6874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
  4 15  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-436

>  <JC_XSMILES>
CCOP1(=O)COC2=CC=CC=C2OC1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.145

>  <W2 Pf proliferation inhibition EC50 uM>
>1.383

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4360
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 11 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 10 26  1  0  0  0  0
M  CHG  2  19   1  20  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4360

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(C=C3)[N+]([O-])=O)C(=O)CCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.902

>  <W2 Pf proliferation inhibition EC50 uM>
0.57

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011363636

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4366
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    2.8972    3.8750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.0808    3.0707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8691    2.8275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0527    2.0232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4479    1.4620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6596    1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4760    2.5095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6315    0.6577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4358    0.4742    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7938   -0.2691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4358   -1.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9502   -1.6575    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6315   -1.1960    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9865   -0.6816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -1.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5575   -0.6816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5575    0.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8431    0.5559    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720    0.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9865    0.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9502    1.1192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6488    1.8871    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7660    0.9962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2804    1.6412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0961    1.5183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6105    2.1633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4263    2.0403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7277    1.2723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2133    0.6273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3976    0.7503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
  8 20  1  0  0  0  0
 14 20  4  0  0  0  0
  9 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 25 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4366

>  <JC_XSMILES>
FC1=CC=C(C=C1)C2N(CC(=O)NC3=CC=C(F)C=C23)C(=O)CCC4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.566

>  <W2 Pf proliferation inhibition EC50 uM>
0.365

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
64.39

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4367
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6484    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6484    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  5 14  4  0  0  0  0
  9 14  4  0  0  0  0
  2 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 16 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4367

>  <JC_XSMILES>
OC(CNC1=CC=CC2=CC=CC=C12)CN3C4=CC=C(Cl)C=C4C5=CC(Cl)=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
0.403

>  <W2 Pf proliferation inhibition EC50 uM>
0.3063

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
54.21

>  <Powder data?>
Yes

>  <IFI value>
0.057692308

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4370
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    3.2789    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2426   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0676   -0.3020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2426    0.5230    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2426   -1.1270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 28 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4370

>  <JC_XSMILES>
CC1CCN(CC1)C2=NC(C)=NC3=C2C(C)=C(S3)C(=O)NC4=CC=C(C=C4)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.562

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4374
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
  7 24  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4374

>  <JC_XSMILES>
ClC1=CC=C(NC2=NC(NC3=CC=C(Cl)C=C3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.148

>  <W2 Pf proliferation inhibition EC50 uM>
0.1102

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.64

>  <Powder data?>
Yes

>  <IFI value>
0.037267081

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4375
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.1895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -1.7605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0294   -3.2820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8499   -3.3682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1854   -2.6145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4774   -3.8951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7323   -4.6797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6704   -3.7235    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4375

>  <JC_XSMILES>
CCCN(CCC)S(=O)(=O)C1=CC(Br)=CC2=C1N(CC2)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.988

>  <W2 Pf proliferation inhibition EC50 uM>
0.561

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4378
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -2.4243   -1.4900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6397   -1.7450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4681   -2.5519    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007   -3.7080    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6077   -3.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0202   -4.5940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6077   -5.3084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7827   -5.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8452   -4.5940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2577   -3.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8452   -3.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2577   -2.4506    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8452   -1.7361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0202   -3.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  4  0  0  0  0
  3 15  4  0  0  0  0
  6 15  4  0  0  0  0
  4 16  2  0  0  0  0
 16 17  1  4  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  2  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
 19 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4378

>  <JC_XSMILES>
CCN1C(SC2=C(OC)C=CC(OC)=C12)=NC(=O)C3=CC(=O)C4=CC=CC=C4O3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.497

>  <W2 Pf proliferation inhibition EC50 uM>
0.0556

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4379
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 12 19  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4379

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)C(=O)C2=CC=C(Cl)C(Cl)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2507

>  <W2 Pf proliferation inhibition EC50 uM>
0.555

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-438
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 21 27  4  0  0  0  0
  6 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 35 37  4  0  0  0  0
 37 38  4  0  0  0  0
 32 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-438

>  <JC_XSMILES>
CCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC(Cl)=C3)C(=O)COC4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.421

>  <W2 Pf proliferation inhibition EC50 uM>
>1.375

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4381
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0396    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4875    2.4777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8465    2.0361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1015    2.8207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9084    2.9922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1634    3.7769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6113    4.3900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8663    5.1746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8044    4.2184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5494    3.4338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 13 24  4  0  0  0  0
 10 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
  9 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4381

>  <JC_XSMILES>
CCC1=CC=C(C=C1)C2N3N=CC(C(=O)NC4=CC=C(C)C=C4)=C3NC(C)=C2C(=O)NC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.504

>  <W2 Pf proliferation inhibition EC50 uM>
0.554

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4382
  Mrv1591402191617072D          

 37 41  0  0  1  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4054    3.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4054    4.0789    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.8179    4.7933    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6429    4.7933    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0554    5.5078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6429    6.2223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8179    6.2223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4054    5.5078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 31 30  1  0  0  0  0
 31 29  1  0  0  0  0
 31 32  1  1  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4382

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4C[C@H]4C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.727

>  <W2 Pf proliferation inhibition EC50 uM>
0.0553

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4384
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
  9 20  1  0  0  0  0
 20 21  2  0  0  0  0
  7 22  4  0  0  0  0
  2 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4384

>  <JC_XSMILES>
CC1=CC(C)=CC(NC2=C(N)C(=O)C3=CC=CC=C3C2=O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.969

>  <W2 Pf proliferation inhibition EC50 uM>
0.551

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4385
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4385

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)C2N(C)C3=CC=CC=C3N2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.913

>  <W2 Pf proliferation inhibition EC50 uM>
0.551

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.057324841

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4386
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.0639   -2.8872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6159   -2.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4229   -2.4457    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5798   -0.8764    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.8348   -0.0918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6418    0.0797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8967    0.8644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  4  0  0  0  0
  7 19  4  0  0  0  0
 19 20  4  0  0  0  0
  4 20  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4386

>  <JC_XSMILES>
CCOC1=CC=C2NC3=NC(SCC=C)=NN=C3C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
5.62

>  <W2 Pf proliferation inhibition EC50 uM>
0.549

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.112903226

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4387
  Mrv1591402191617072D          

 32 35  0  0  1  0            999 V2000
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -12.7875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -11.5500    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302  -12.7875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 16 15  1  0  0  0  0
 16 11  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 14 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
  6 31  4  0  0  0  0
 31 32  4  0  0  0  0
  3 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4387

>  <JC_XSMILES>
COC1=CC=C(CNCCN2CCN(C[C@@H]2CC3=CC=C(O)C=C3)C4=CC=CC=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0521

>  <W2 Pf proliferation inhibition EC50 uM>
0.0549

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.026315789

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4389
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
 18 30  4  0  0  0  0
 14 30  4  0  0  0  0
 30 31  2  0  0  0  0
 17 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  1  0  0  0  0
 32 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4389

>  <JC_XSMILES>
CN1CCN(CC1)CC2=C(O)C=CC3=C2OC(=C(OC4=CC=C(C=C4)C(C)(C)C)C3=O)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.799

>  <W2 Pf proliferation inhibition EC50 uM>
0.547

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4392
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
    3.5723   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8580    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5691    1.6002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0994    0.6817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2296   -1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001    0.8251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8124    0.6818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2821    1.6003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7146    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4291    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1436    4.5375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8580    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5725    3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8580    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 12 19  1  0  0  0  0
 19 20  2  0  0  0  0
 13 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 11 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
 22 30  1  0  0  0  0
 21 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  1  0  0  0  0
 36 38  4  0  0  0  0
 31 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4392

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2C3=C(CC(C)(C)CC3=O)N(C4=C2C(=O)CC(C)(C)C4)C5=CC=C(Cl)C(Cl)=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.43

>  <W2 Pf proliferation inhibition EC50 uM>
0.546

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4393
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    2.0367   -0.4741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4888   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6603   -0.7221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4449   -0.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0580   -1.0192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8865   -1.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1019   -2.0811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4131   -0.7221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3715   -0.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5430    0.3398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0701    0.8918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8547    0.6369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0262   -0.1701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5986   -3.9898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7479   -5.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9275   -5.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4425   -4.8297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7781   -4.0760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  3 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  2 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  4  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 10 20  2  0  0  0  0
 20 21  1  4  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4393

>  <JC_XSMILES>
O=C1N(C2CCCCC2)C(SC1=CC3=CC=CC=C3)=NC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.348

>  <W2 Pf proliferation inhibition EC50 uM>
0.545

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4397
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
   -3.8837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -4.2703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489    0.8152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227    1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    1.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175    3.0199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483    2.5100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
 21 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 31 37  4  0  0  0  0
 37 38  4  0  0  0  0
 20 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4397

>  <JC_XSMILES>
COC1=CC(OC)=CC(=C1)C(=O)OC2=CC=CC=C2C3=C(NC(C)(C)CC(C)(C)C)N4C=CC(C)=CC4=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.946

>  <W2 Pf proliferation inhibition EC50 uM>
0.054

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028037383

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4401
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    2.8579   11.3036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   10.0661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   10.0661    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   11.3036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   11.7161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   12.5411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   12.9536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   12.5411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   11.7161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    9.2411    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184    9.2411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684    9.2411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.5286    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.5286    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964    4.2187    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414    3.4340    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315    2.7666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615    4.2187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4401

>  <JC_XSMILES>
CC(C)N(CC1=CC=CC=C1)S(=O)(=O)C2=CC=C(C=C2)C(=O)NC3=NOC(C)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.688

>  <W2 Pf proliferation inhibition EC50 uM>
0.538

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4402
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    2.4856   -3.3002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3106   -3.3002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7231   -4.0147    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3106   -4.7291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4856   -4.7291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5481   -4.0147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9606   -4.7291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7856   -4.7291    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1981   -5.4436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7856   -6.1581    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1981   -6.8726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0231   -6.8726    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4356   -6.1581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0231   -5.4436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5751   -4.8305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3288   -5.1661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0825   -4.8305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7499   -5.3154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6637   -6.1359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3311   -6.6208    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.9100   -6.4715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2426   -5.9866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 13 22  4  0  0  0  0
 16 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4402

>  <JC_XSMILES>
CCN(CC)CCNC1=NC=NC2=C1NC3=CC=C(F)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2774

>  <W2 Pf proliferation inhibition EC50 uM>
0.1694

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
31.53

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4403
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  8 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  1  0  0  0  0
  6 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4403

>  <JC_XSMILES>
CC1=CC=CC(NC(C2=CC=NC=C2)C3=CC=C4C=CC=NC4=C3O)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.669

>  <W2 Pf proliferation inhibition EC50 uM>
0.375

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
69.88

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4404
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    4.7079    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  4  0  0  0  0
 14 19  4  0  0  0  0
  7 20  4  0  0  0  0
  2 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4404

>  <JC_XSMILES>
CC1=CC(C)=CC(NC2=CC(C)=NC3=NC(C)=NN23)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.594

>  <W2 Pf proliferation inhibition EC50 uM>
0.536

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4407
  Mrv1591402191617072D          

 15 15  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4407

>  <JC_XSMILES>
CCCCSCC(O)CN1CCCCC1

>  <PF proliferation inhibition 3D7 EC50 uM>
5.28

>  <W2 Pf proliferation inhibition EC50 uM>
0.534

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4409
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
  5 16  4  0  0  0  0
 16 17  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4409

>  <JC_XSMILES>
CCCCC1=C(C)N=C2C=CC(Br)=CC2=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.962

>  <W2 Pf proliferation inhibition EC50 uM>
0.532

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4412
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.8018   -4.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498   -4.0609    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498    3.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8018    4.1641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6088    3.9926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1608    4.6056    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9059    5.3903    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 15 22  4  0  0  0  0
 11 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
  9 27  4  0  0  0  0
 23 27  4  0  0  0  0
M  CHG  1  11   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4412

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C[N+](CC(=O)C3=CC=CC(OC)=C3)=C4CCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.954

>  <W2 Pf proliferation inhibition EC50 uM>
0.53

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.025

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4414
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 10 17  4  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4414

>  <JC_XSMILES>
CCN1CCN(CC1)CC2=CC(Cl)=CC(Cl)=C2O

>  <PF proliferation inhibition 3D7 EC50 uM>
3.004

>  <W2 Pf proliferation inhibition EC50 uM>
0.529

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4419
  Mrv1591402191617072D          

 30 31  0  0  1  0            999 V2000
    1.8974   -1.4869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7076   -1.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2477   -1.9546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0578   -1.7987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5979   -2.4224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4080   -2.2665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6781   -1.4869    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9481   -2.8901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7582   -2.7342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0283   -1.9546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4882   -1.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8384   -1.7987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6781   -3.6696    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2632   -4.2512    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.0411   -3.9763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1734   -5.0713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8734   -5.5080    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4763   -5.5124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6967   -5.2423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1605   -5.8694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3494   -5.7185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0745   -4.9407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2634   -4.7898    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9885   -4.0120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5247   -3.3850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1774   -3.8611    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6107   -4.3137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4218   -4.4645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8585   -3.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4174   -3.0674    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
  8 13  1  0  0  0  0
 14 13  1  0  0  0  0
 14 15  1  1  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
 19 28  4  0  0  0  0
 28 29  1  0  0  0  0
 13 29  1  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4419

>  <JC_XSMILES>
CCCCNC(=O)C(CC(C)C)N1[C@@H](C)C(=O)NC2=CC=C(NC(C)=O)C=C2C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02825

>  <W2 Pf proliferation inhibition EC50 uM>
0.0672

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>12.76

>  <Powder data?>
No

>  <IFI value>
0.024691358

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4421
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
  6 17  4  0  0  0  0
 17 18  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4421

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C=CC(CC)=CC2=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.716

>  <W2 Pf proliferation inhibition EC50 uM>
0.525

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4422
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -3.6791   10.1277    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501   10.1277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    8.8902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    8.8902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    8.4777    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2337    7.7632    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4087    9.1922    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    8.0652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    7.2402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    7.2402    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.0027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186    4.2803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637    3.4956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387    3.4956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837    4.2803    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4422

>  <JC_XSMILES>
ClC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=S)NCC3=CC=CO3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.973

>  <W2 Pf proliferation inhibition EC50 uM>
0.524

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4425
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
  6 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4425

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C=CC=CC2=C1NC3=CC=C(C=C3)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.343

>  <W2 Pf proliferation inhibition EC50 uM>
0.386

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>73.81

>  <Powder data?>
Yes

>  <IFI value>
0.061538462

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4428
  Mrv1591402191617072D          

 31 33  0  0  1  0            999 V2000
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  9  8  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  1  6  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
  7 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 25 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4428

>  <JC_XSMILES>
CN(C)[C@@H]1CCN(C[C@@H]1CCC(=O)NCCCN2CCOCC2)CC3=CC=CC(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.593

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01536

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>2.944

>  <Powder data?>
No

>  <IFI value>
0.018181818

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4429
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    2.4820    0.5756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1964    0.1631    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1964   -0.6619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9109    0.5756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6254    0.1631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6254   -0.6619    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3399    0.5756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0543    0.1631    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8080    0.4987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0629    1.2833    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8699    1.4548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4220    0.8418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1670    0.0571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3600   -0.1144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9475   -0.8289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2025   -1.6135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6504   -2.2266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8435   -2.0551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5885   -1.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1406   -0.6573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  8 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4429

>  <JC_XSMILES>
CN(C)CC(O)CN1C2=CC=CC=C2C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.74

>  <W2 Pf proliferation inhibition EC50 uM>
0.2748

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
52.77

>  <Powder data?>
Yes

>  <IFI value>
0.038167939

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4431
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    2.0329   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329    0.6039    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2079    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954    1.3184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0296    1.3184    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4421    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2671    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6796    1.3184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2671    2.0329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4421    2.0329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
  4 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 14 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4431

>  <JC_XSMILES>
CC1=CC(NCCN2CCCCC2)=C3C=CC4=CC=CC=C4C3=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0441

>  <W2 Pf proliferation inhibition EC50 uM>
0.081

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.59

>  <Powder data?>
Yes

>  <IFI value>
0.070175439

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4432
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    2.1434   -4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.4105    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -4.8395    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
  9 23  4  0  0  0  0
  5 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4432

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(NC2=CC(=O)C3=CC=CC=C3C2=O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.549

>  <W2 Pf proliferation inhibition EC50 uM>
0.519

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.070422535

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4433
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007   -6.1830    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6077   -6.3545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0202   -5.6400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4681   -5.0269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6129   -5.0269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1649   -5.6400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7524   -6.3545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9454   -6.1830    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
  1 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4433

>  <JC_XSMILES>
C(COC1=CC=C(C=C1)C2=NCCN2)COC3=CC=C(C=C3)C4=NCCN4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00558

>  <W2 Pf proliferation inhibition EC50 uM>
0.0518

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018348624

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4435
  Mrv1591402191617072D          

 35 40  0  0  0  0            999 V2000
    6.4938   -3.1948    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8053   -3.6493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8546   -4.4728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4718   -5.0202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9244   -5.6375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3072   -5.0900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0674   -3.2803    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4148   -3.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6133   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2665   -2.8408    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6355   -2.1029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -1.4898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2765   -1.6613    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7245   -1.0482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9175   -1.2198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3655   -0.6067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4415   -0.7782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9935   -0.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7386    0.6195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0684    0.7910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6204    0.1779    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3385   -0.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1454   -0.5337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6975   -1.1468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4425   -1.9314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0798   -2.4553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4004    0.2510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9154    0.9184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4004    1.5858    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1850    1.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    1.7434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6139    1.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6139    0.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    0.0934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1850    0.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  3  6  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 12 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  4  0  0  0  0
 25 26  1  0  0  0  0
  7 26  1  0  0  0  0
 23 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 27 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4435

>  <JC_XSMILES>
O=C(C1CCC1)N2CCOC3=C(OCCC4=CC=CC=N4)C=C(C=C3C2)C5=CSC6=CC=CC=C56

>  <PF proliferation inhibition 3D7 EC50 uM>
0.754

>  <W2 Pf proliferation inhibition EC50 uM>
0.515

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>99.62

>  <Powder data?>
Yes

>  <IFI value>
0.02

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4437
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4437

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(Cl)=C(C=C1N2CCOCC2)N3CCOCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.036

>  <W2 Pf proliferation inhibition EC50 uM>
0.515

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.014388489

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4438
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    6.9246    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    5.6479    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.3523    6.0604    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.9233    6.0604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -0.1006    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -0.5422    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -1.9399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -2.7246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -2.8961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -3.6807    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -2.2830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -1.4984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 17 18  1  0  0  0  0
  9 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
 14 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 31 37  4  0  0  0  0
  5 38  4  0  0  0  0
 38 39  1  0  0  0  0
 38 40  4  0  0  0  0
  2 40  4  0  0  0  0
M  CHG  2  25   1  26  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4438

>  <JC_XSMILES>
CC1=CC=C(NC(=O)C2=C(C)NC3=C(C=NN3C2C4=CC=C(C=C4)[N+]([O-])=O)C(=O)NC5=CC=C(F)C=C5)C(C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.585

>  <W2 Pf proliferation inhibition EC50 uM>
0.514

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-444
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
  8 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
 33 34  1  0  0  0  0
  6 35  4  0  0  0  0
 35 36  4  0  0  0  0
  3 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-444

>  <JC_XSMILES>
COC1=CC=C(CN(CC2CCN(CC2)C(=O)C3=CC=CC=C3Cl)C(=O)C4=CC=C(Cl)C=C4Cl)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
7.25

>  <W2 Pf proliferation inhibition EC50 uM>
3.31

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
24.3

>  <Powder data?>
Yes

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4443
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
  4 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  2 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  CHG  2  13   1  14  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4443

>  <JC_XSMILES>
CC1=CC(NC2=CC=C(C=C2O)[N+]([O-])=O)=NC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.357

>  <W2 Pf proliferation inhibition EC50 uM>
0.1437

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
28.05

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4446
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -1.6549   -3.5227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6549   -4.3477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9404   -4.7602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9404   -5.5852    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6549   -5.9977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6549   -6.8227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3693   -5.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3693   -4.7602    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0838   -5.9977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0838   -6.8227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7983   -7.2352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5127   -6.8227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2272   -7.2352    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5127   -5.9977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2272   -5.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2272   -4.7602    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9417   -4.3477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9417   -3.5227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2239   -2.7474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6936   -2.1154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8811   -2.2587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5989   -3.0340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1292   -3.6659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7542   -3.6659    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0363   -4.4412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8488   -4.5844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3791   -3.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0969   -3.1772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2845   -3.0340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7983   -5.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 18 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
 14 30  4  0  0  0  0
  9 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4446

>  <JC_XSMILES>
CC1=CN=C(C)C(=N1)C2=CC=C(O)C(CNCC3(CCCCC3)N4CCCCC4)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.326

>  <W2 Pf proliferation inhibition EC50 uM>
0.0398

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>7.78

>  <Powder data?>
No

>  <IFI value>
0.009708738

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4448
  Mrv1591402191617072D          

 30 35  0  0  0  0            999 V2000
    3.6461    3.0977    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4772    2.2901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3082    1.4826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9230    0.9325    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7432    1.0214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0812    0.2688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4698   -0.2852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7541    0.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9703   -0.1324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8013   -0.9399    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4161   -1.4900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2472   -2.2975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4633   -2.5549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8485   -2.0048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0175   -1.1973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2944   -3.3624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9092   -3.9125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7402   -4.7200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9564   -4.9775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3416   -4.4274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5106   -3.6199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3554    0.4177    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5352    0.3289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0524   -0.3401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2317   -0.2565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1063    0.4961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3765    1.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1973    1.0815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8086    1.6354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5244    1.2252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  3  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
  9 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
  3 30  4  0  0  0  0
 22 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4448

>  <JC_XSMILES>
N#CC1=C2CCCC2=C(N3CCN(CC3)C4CCCCC4)N5C6=CC=CC=C6N=C15

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1832

>  <W2 Pf proliferation inhibition EC50 uM>
0.511

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.014705882

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4449
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1839   -5.0269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7359   -5.6400    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3234   -6.3545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6590   -7.1082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5165   -6.1830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4449

>  <JC_XSMILES>
CCCCOC1=CC=C(C=C1)C(=O)NC2=NOC(C)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
3.161

>  <W2 Pf proliferation inhibition EC50 uM>
0.51

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4450
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 11 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 10 26  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4450

>  <JC_XSMILES>
COC1=CC=CC=C1NC2=C(N3CCCCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02802

>  <W2 Pf proliferation inhibition EC50 uM>
0.0401

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.87

>  <Powder data?>
Yes

>  <IFI value>
0.176470588

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4451
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
  6 11  4  0  0  0  0
  3 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 12 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 24 32  4  0  0  0  0
 20 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4451

>  <JC_XSMILES>
OC1=C(C=CC2=CC=CN=C12)C(NC3=CC=CC=N3)C4=CC=CC(OC5=CC=CC=C5)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.328

>  <W2 Pf proliferation inhibition EC50 uM>
0.32

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
62.82

>  <Powder data?>
Yes

>  <IFI value>
0.123076923

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4452
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -3.8837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4452

>  <JC_XSMILES>
CC(C)N(C)CC1=CC(=CC=C1O)C2=NC3=CC=CC=C3S2

>  <PF proliferation inhibition 3D7 EC50 uM>
7.87

>  <W2 Pf proliferation inhibition EC50 uM>
0.509

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.080357143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4454
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    4.1763    5.1414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    5.1414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138    4.4270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1763    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388    4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6513    5.1414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6513    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8888    2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138    2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1263    2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138    1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8888    1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763    2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1263    0.8546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9513    0.8546    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3638    0.1401    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.9513   -0.5743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3638   -1.2888    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.1888   -1.2888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6013   -2.0033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1888   -2.7177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3638   -2.7177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9513   -2.0033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1263   -0.5743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138   -1.2888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8888   -1.2888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -0.5743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8888    0.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138    0.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 19 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 16 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4454

>  <JC_XSMILES>
CCN(CC)C(=O)COC1=CC=C(C=C1)C2=NN=C(N3CCCCC3)C4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
1.738

>  <W2 Pf proliferation inhibition EC50 uM>
0.508

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.030769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4456
  Mrv1591402191617072D          

 50 59  0  0  0  0            999 V2000
   11.0328    6.0346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2078    6.0346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7953    6.7491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9703    6.7491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5578    6.0346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9703    5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7953    5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5578    4.6057    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8933    3.8520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7003    3.6805    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7373    4.5195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1853    5.1326    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6689    3.0661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0814    3.7806    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9947    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7092    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4236    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4236    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7092    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9947    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7373   -1.2195    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5578   -1.3057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8933   -0.5520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9233    0.9826    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4383    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9233    2.3174    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 13 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 11 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 18 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 29 33  4  0  0  0  0
 33 34  4  0  0  0  0
 26 34  4  0  0  0  0
 25 35  2  0  0  0  0
 15 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 42 43  1  0  0  0  0
 39 43  4  0  0  0  0
 43 44  4  0  0  0  0
 36 44  4  0  0  0  0
 15 45  1  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 48 49  4  0  0  0  0
 49 50  4  0  0  0  0
 45 50  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4456

>  <JC_XSMILES>
CC1=CC=CC(=C1)N2C(=O)C3C(C2=O)C4(C(=O)C3(C5=CC=CC=C5)C(C6=CC=C7OCOC7=C6)=C4C8=CC=C9OCOC9=C8)C%10=CC=CC=C%10

>  <PF proliferation inhibition 3D7 EC50 uM>
1.073

>  <W2 Pf proliferation inhibition EC50 uM>
0.508

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4457
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 13 19  1  0  0  0  0
 14 20  4  0  0  0  0
 20 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4457

>  <JC_XSMILES>
CC1CCCCN1S(=O)(=O)C2=CC3=C(NC(=O)CO3)C=C2C

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.505

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4458
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  2  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  4  0  0  0  0
 15 31  4  0  0  0  0
 22 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4458

>  <JC_XSMILES>
CCC1CCCCN1CCCNC(=O)C2=CN(CC)C(=O)C3=CC(OC)=C(OC)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.449

>  <W2 Pf proliferation inhibition EC50 uM>
0.505

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4461
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  2 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 21 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 25 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4461

>  <JC_XSMILES>
O=C(N1CCN(CC1)CC2=CC=CC=C2)C3=CC=C4N=C(SC4=C3)N5CCCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.907

>  <W2 Pf proliferation inhibition EC50 uM>
0.503

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4462
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4462

>  <JC_XSMILES>
COC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N(C)C(=O)NC4=CC=CC=C4F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1616

>  <W2 Pf proliferation inhibition EC50 uM>
0.0623

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>12.4

>  <Powder data?>
No

>  <IFI value>
0.049019608

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4469
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.9000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 16 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4469

>  <JC_XSMILES>
CCOC(=O)COC1=CC=C(C=C1OC)C2NC(=S)NC(C)=C2C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
4.03

>  <W2 Pf proliferation inhibition EC50 uM>
0.496

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-447
  Mrv1591402191617072D          

 35 37  0  0  0  0            999 V2000
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3260    0.9019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8781    1.5150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4656    2.2295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6586    2.0580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
 12 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 10 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
  6 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-447

>  <JC_XSMILES>
COC1=CC=C(CCNC2=NC(NCCCN3CCCC3)=NC=C2C(=O)NCC(C)C)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.809

>  <W2 Pf proliferation inhibition EC50 uM>
>1.351

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.00952381

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4470
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
   10.6265    5.0142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8060    5.1005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2540    4.4874    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5003    4.8229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5865    5.6434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9734    6.1955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3935    5.8150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7858    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7858    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  2  7  4  0  0  0  0
  4  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 24 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 22 30  4  0  0  0  0
 11 31  4  0  0  0  0
 31 32  4  0  0  0  0
  8 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4470

>  <JC_XSMILES>
CC1=NN(C(C)=C1)C2=CC=C(NC(=O)C3CCN(CC3)CC4=CC5=NON=C5C=C4)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.43

>  <W2 Pf proliferation inhibition EC50 uM>
0.412

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>83.17

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4474
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.1612   -1.5395    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.9862   -0.1105    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4474

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC=C(C=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1658

>  <W2 Pf proliferation inhibition EC50 uM>
0.319

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
64.64

>  <Powder data?>
Yes

>  <IFI value>
0.027272727

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4476
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    2.5820   -6.1716    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.0300   -5.5585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2230   -5.7301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9259   -4.3323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2849   -4.7739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.9870   -3.1672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2392   -4.2713    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2203   -0.9238    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2822   -1.8800    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3441   -2.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8961   -2.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6412   -1.4384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8342   -1.2669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 17 22  4  0  0  0  0
 12 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 25 30  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4476

>  <JC_XSMILES>
ClC1=CC=C(C=C1)S(=O)(=O)NC(CC2=CNC3=CC=CC=C23)C(=O)N4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.719

>  <W2 Pf proliferation inhibition EC50 uM>
0.488

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4477
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007   -1.2330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6077   -1.4045    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0202   -0.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4681   -0.0769    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8407   -0.6038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3256   -1.2712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1461   -1.1850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4816   -0.4313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9967    0.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1762    0.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  2  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   3
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4477

>  <JC_XSMILES>
O=C1NN(CC2COC(O2)C3=CC=CC=C3)C(=O)C4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
0.678

>  <W2 Pf proliferation inhibition EC50 uM>
0.488

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4480
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    3.6130    4.9232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0255    4.2087    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6130    3.4942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0255    2.7797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6130    2.0653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7880    2.0653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3755    2.7797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5505    2.7797    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1380    3.4942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7880    3.4942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3755    4.2087    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5505    4.2087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0255    1.3508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8505    1.3508    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6130    0.6363    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7880    0.6363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4300    1.3796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6257    1.5632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9807    1.0488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9807    0.2238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6257   -0.2905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4300   -0.1070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3940    0.6363    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5690    0.6363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1455    0.2238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1455    1.0488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 16 22  1  0  0  0  0
 21 23  1  0  0  0  0
 18 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4480

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1OC)C(=O)NC2CC3CCC(C2)N3C4CC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.45

>  <W2 Pf proliferation inhibition EC50 uM>
0.487

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4485
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 12 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4485

>  <JC_XSMILES>
OC1=CC=C(Cl)C=C1C(=O)NC2=C3C=CC=CC3=NC4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
1.13

>  <W2 Pf proliferation inhibition EC50 uM>
0.484

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4487
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
   -1.2670   -0.8675    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.8243   -1.4757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3817   -0.8674    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4118   -2.1901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6974   -2.6026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0171   -2.1901    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7316   -2.6026    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
    0.3191   -3.3171    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4460   -3.0151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1605   -2.6026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8750   -3.0151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8750   -3.8401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1605   -4.2526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4460   -3.8401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1441   -1.8882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7316   -1.1737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1441   -0.4592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9691   -0.4592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3816   -1.1737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9691   -1.8882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2368   -2.1901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9513   -2.6026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9513   -3.4276    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6658   -3.8401    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0783   -3.1257    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3803   -4.2526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3803   -5.0776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0947   -5.4901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8092   -5.0776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8092   -4.2526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0947   -3.8401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2533   -4.5546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4283   -4.5546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0158   -5.2691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4283   -5.9835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2533   -5.9835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6658   -5.2691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  7 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  4 21  1  0  0  0  0
  2 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 24 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4487

>  <JC_XSMILES>
ClC1(Cl)C(COP(=S)(C2=CC=CC=C2)C3=CC=CC=C3)C1COP(=S)(C4=CC=CC=C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.385

>  <W2 Pf proliferation inhibition EC50 uM>
0.484

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4488
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
 10 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 14 21  4  0  0  0  0
  9 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
  8 30  1  0  0  0  0
 30 31  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4488

>  <JC_XSMILES>
CN1CCN(CC1)C2=C(N(C(C)=O)C3=CC(C)=CC(C)=C3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.067

>  <W2 Pf proliferation inhibition EC50 uM>
0.0612

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.65

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4491
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 20 21  2  0  0  0  0
 11 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  3  0  0  0  0
 17 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4491

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2CC(=O)N3CN(CSC3=C2C#N)CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.638

>  <W2 Pf proliferation inhibition EC50 uM>
0.482

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4492
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.0215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8538   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1893   -5.2273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7044   -5.8947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8839   -5.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3990   -6.4759    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.5484   -5.0548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0333   -4.3874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2991   -2.7666    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1276   -1.9596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7407   -1.4076    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3430   -1.7047    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1714   -0.8977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6132   -0.6428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7847    0.1642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1716    0.7162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3431    1.5232    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.6130    0.4613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7845   -0.3457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -0.6006    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.6486   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1335   -5.1410    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9812   -4.9585    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3160   -3.9887    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
  6 12  4  0  0  0  0
  5 13  4  0  0  0  0
  2 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 24 25  1  0  0  0  0
  4 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4492

>  <JC_XSMILES>
CN1N=C(C(C2=CC=C(Br)C=C2)=C1NC(=O)NC3=CC=C(F)C=C3F)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2115

>  <W2 Pf proliferation inhibition EC50 uM>
0.2062

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
42.82

>  <Powder data?>
Yes

>  <IFI value>
0.008403361

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4497
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3058    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8933    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0863    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
  5 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 13 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 12 27  1  0  0  0  0
 27 28  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4497

>  <JC_XSMILES>
CC(=O)N(C1=CC=C(I)C=C1)C2=C(N3CCCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.553

>  <W2 Pf proliferation inhibition EC50 uM>
0.2244

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
46.95

>  <Powder data?>
Yes

>  <IFI value>
0.013333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4498
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    2.2374    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.9284    1.5229    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -5.1659    2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 36 38  2  0  0  0  0
M  CHG  2  36   1  37  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4498

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4=CC=C(C)C(=C4)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.744

>  <W2 Pf proliferation inhibition EC50 uM>
0.0477

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4499
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -4.2355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -5.6645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 15 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
  8 23  4  0  0  0  0
 23 24  4  0  0  0  0
  5 24  4  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4499

>  <JC_XSMILES>
CC(=O)NC1=CC=C(NS(=O)(=O)C2=CC(=CC=C2Cl)[N+]([O-])=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.475

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-450
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8971   -5.0269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4491   -5.6400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0366   -6.3545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2296   -6.1830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 11 21  4  0  0  0  0
 21 22  4  0  0  0  0
  8 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 25 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-450

>  <JC_XSMILES>
CC(C)CNC(=O)C1=CN=C(NCCCN2CCCC2)N=C1NCC3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.474

>  <W2 Pf proliferation inhibition EC50 uM>
>1.35

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.00952381

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4503
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -2.0470    2.8379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8128   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4628   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 14 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
  7 30  4  0  0  0  0
  2 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4503

>  <JC_XSMILES>
CC1=CC=C(O)C(NC(=O)C2=C3N=C(C=C(N3N=C2)C(F)(F)F)C4=CC=CC=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.816

>  <W2 Pf proliferation inhibition EC50 uM>
0.472

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4506
  Mrv1591402191617072D          

 36 41  0  0  0  0            999 V2000
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2487    3.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007    4.2631    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3882    4.9775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7238    5.7312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5442    5.8174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8798    6.5711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3949    7.2386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5744    7.1523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2388    6.3986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4188    4.8060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0319    5.3580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8603    6.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4734    6.7170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2580    6.4621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4296    5.6551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8165    5.1031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  7 14  4  0  0  0  0
  4 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  2 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 22 36  4  0  0  0  0
 30 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4506

>  <JC_XSMILES>
OC(CN1C=NC(C2=CC=CC=C2)=C1C3=CC=CC=C3)CN4C5=CC=C(Cl)C=C5C6=CC(Cl)=CC=C46

>  <PF proliferation inhibition 3D7 EC50 uM>
0.589

>  <W2 Pf proliferation inhibition EC50 uM>
0.0997

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.2

>  <Powder data?>
Yes

>  <IFI value>
0.023255814

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4507
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
  8 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
  7 23  1  0  0  0  0
 23 24  2  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4507

>  <JC_XSMILES>
ClC1=CC=C(NC2=C(N3CCCCC3)C(=O)C4=CC=CC=C4C2=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.319

>  <W2 Pf proliferation inhibition EC50 uM>
0.2498

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
53.16

>  <Powder data?>
Yes

>  <IFI value>
0.053333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4509
  Mrv1591402191617072D          

 30 35  0  0  0  0            999 V2000
    1.8147   -4.3198    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1002   -4.7324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3857   -4.3199    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3857   -3.4949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3288   -3.0824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3289   -2.2574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3856   -1.8449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1001   -2.2574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1001   -3.0824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3855   -1.0199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3499   -1.3936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0995   -0.6033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0995    0.1441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8350    0.5178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5706    0.1441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5706   -0.6033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8350   -0.9770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1211   -1.3936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3682   -0.8143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9497   -0.2290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7473   -0.4400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9634   -1.2362    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3819   -1.8214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5843   -1.6104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3855   -0.2725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1003   -5.5574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7677   -6.0422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5128   -6.8269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6878   -6.8269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4328   -6.0423    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 13 14  1  0  0  0  0
 12 17  1  0  0  0  0
 10 18  1  0  0  0  0
 16 17  1  0  0  0  0
 14 25  1  0  0  0  0
 16 18  1  0  0  0  0
 15 16  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 10 25  1  0  0  0  0
 12 13  1  0  0  0  0
  2 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4509

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)C23CC4CC(CC(C4)(C2)C5=CC=CC=C5)C3)C6=CC=CS6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.645

>  <W2 Pf proliferation inhibition EC50 uM>
0.468

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4511
  Mrv1591402191617072D          

 30 34  0  0  1  0            999 V2000
    1.7174    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7174    0.9916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4319    1.4041    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.4319    2.2291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1464    2.6416    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2839    2.0916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2839    1.5416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1464    0.9916    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.8608    1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8608    2.2291    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.5753    2.6416    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.5753    3.4666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2898    3.8791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0043    3.4666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2898    4.7041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0043    5.1166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0905    5.9371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8975    6.1086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3100    5.3941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7579    4.7810    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.2898    2.2291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0043    2.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7187    2.2291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7187    1.4041    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0043    0.9916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0043    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2898   -0.2459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5753    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5753    0.9916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2898    1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  3  2  1  1  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  6  0  0  0
  3  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  0  0  0  0
 10  5  1  0  0  0  0
 10 11  1  1  0  0  0
 11 12  1  1  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 11 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 21 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4511

>  <JC_XSMILES>
C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](OC(=O)CC3=CC=CS3)C4=CC=NC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0622

>  <W2 Pf proliferation inhibition EC50 uM>
0.0466

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.025

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4512
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    5.3203    2.0754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0347    2.4879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0347    3.3129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7492    2.0754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4637    2.4879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1782    2.0754    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8926    2.4879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6071    2.0754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6071    1.2504    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3216    2.4879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0360    2.0754    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.7897    2.4110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0447    3.1956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8516    3.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4037    2.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2106    2.9256    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   13.1487    1.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3417    1.7979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9292    1.0834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1842    0.2988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6322   -0.3143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8871   -1.0989    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   10.8252   -0.1428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5702    0.6419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1223    1.2550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  4  0  0  0  0
 19 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4512

>  <JC_XSMILES>
CC(C)CCNCC(O)CN1C2=CC=C(Br)C=C2C3=CC(Br)=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2701

>  <W2 Pf proliferation inhibition EC50 uM>
0.0885

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19

>  <Powder data?>
Yes

>  <IFI value>
0.100719424

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4513
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
   -3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
  5 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 39 40  4  0  0  0  0
  3 40  4  0  0  0  0
M  CHG  2  31   1  32  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4513

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=CC=C2OC)C(=O)C3=CC=C(Cl)C(=C3)[N+]([O-])=O)=C4N=CC=CC4=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.204

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01821

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>3.91

>  <Powder data?>
No

>  <IFI value>
0.054347826

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4515
  Mrv1591402191617072D          

 25 27  0  0  1  0            999 V2000
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264    2.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964    1.3099    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256    0.3627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7077    1.1380    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -0.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7683   -0.6990    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  7  6  1  6  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  1  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 10 15  4  0  0  0  0
  9 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  3  0  0  0  0
 16 19  1  0  0  0  0
 19 20  3  0  0  0  0
 16 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
  6 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4515

>  <JC_XSMILES>
CCN1CC=C2[C@H](C1)[C@@H](C3=CC=C(C)S3)C(C#N)(C#N)C(N)=C2C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
1.678

>  <W2 Pf proliferation inhibition EC50 uM>
0.464

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.032786885

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4516
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    9.0364   -0.6710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4843   -1.2841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6774   -1.1126    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1253   -1.7257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3803   -2.5103    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3184   -1.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7663   -2.1672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9594   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7044   -1.2111    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2564   -0.5980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0634   -0.7695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3454   -1.6527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9524    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 18 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4516

>  <JC_XSMILES>
CCOC(=O)C1CCN(CC1)C(=O)C2=C(C)OC3=C2C(=O)C4=CC=CC=C4C3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2007

>  <W2 Pf proliferation inhibition EC50 uM>
0.1027

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
22.18

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4517
  Mrv1591402191617072D          

 14 13  0  0  0  0            999 V2000
    0.8250    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0625    0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750    1.4289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3000    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7125    2.1434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7125    0.7145    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500   -1.4289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  4  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  2  0  0  0  0
  2  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4517

>  <JC_XSMILES>
CC(=NNC(N)=S)C(C)=NNC(N)=S

>  <PF proliferation inhibition 3D7 EC50 uM>
0.572

>  <W2 Pf proliferation inhibition EC50 uM>
0.462

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011235955

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-452
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    1.8465   -1.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -0.4849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4211    0.9744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0886    1.4593    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5074    0.1539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945   -2.4454    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2195   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -3.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945   -3.8743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -4.5888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -4.5888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445   -3.8743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -3.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
  6 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
  3 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-452

>  <JC_XSMILES>
CCN1C(=O)N(CC(N)=O)C(=O)C12CCN(CC2)CC3=CC=C(C=C3)N(C)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
7.79

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
57.8

>  <Powder data?>
Yes

>  <IFI value>
0.038461538

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4520
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5700    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
  5 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 13 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 12 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4520

>  <JC_XSMILES>
CC(=O)N(C1=CC=CC(F)=C1)C2=C(N3CCCCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1462

>  <W2 Pf proliferation inhibition EC50 uM>
0.1089

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.66

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4522
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -3.5782   -0.8637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7578   -0.7774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3453   -0.0630    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5383   -0.2345    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4521   -1.0550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -1.0550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6914   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6914   -2.2925    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4058   -1.0550    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1203   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8348   -1.0550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9210   -0.2345    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7280   -0.0630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1405   -0.7774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5884   -1.3905    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2057   -1.3905    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3773   -2.1975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7642   -2.7495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9357   -3.5565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7203   -3.8115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8918   -4.6184    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3334   -3.2594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1619   -2.4525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
  5 17  4  0  0  0  0
  2 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4522

>  <JC_XSMILES>
CC1=NN=C(SCC(=O)NCC2=CC=CO2)N1C3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>8.95

>  <W2 Pf proliferation inhibition EC50 uM>
0.459

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4524
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4524

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2=NC(=CN=C2N)C3=CC=NC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0358

>  <W2 Pf proliferation inhibition EC50 uM>
0.0457

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4526
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    2.5923   -6.8754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8472   -6.0908    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6542   -5.9193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2952   -5.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5501   -4.6931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9981   -4.0800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2530   -3.2954    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7681   -2.6279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9431   -2.6279    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2530   -1.9605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9981   -1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2134   -0.9209    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2134   -0.0959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6004    0.4561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7719    1.2631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5565    1.5180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1696    0.9660    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9981    0.1590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4830   -0.5084    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0376   -2.2154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7521   -1.8029    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4666   -2.2154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1810   -1.8029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8955   -1.3904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4666   -3.0404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7521   -3.4529    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0376   -3.0404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1810   -3.4529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8955   -3.8654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  3  0  0  0  0
 22 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  7 27  4  0  0  0  0
 20 27  4  0  0  0  0
 25 28  1  0  0  0  0
 28 29  3  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4526

>  <JC_XSMILES>
CN(C)CCCN1C(N)=C(C2=NC3=CC=CC=C3N2)C4=NC(C#N)=C(N=C14)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.463

>  <W2 Pf proliferation inhibition EC50 uM>
0.2739

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
60.16

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4527
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2032   -2.7666    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8163   -3.3186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6448   -4.1256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6010   -3.0637    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2140   -3.6157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9987   -3.3608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6118   -3.9128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4402   -4.7198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0533   -5.2718    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.6556   -4.9747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0425   -4.4227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2579   -4.6776    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -3.8062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6486   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -3.8062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2991   -2.7666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5145   -2.5117    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.5541   -1.9820    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.0442   -3.5512    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 21 22  1  0  0  0  0
 10 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
  9 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4527

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C(NC(=O)NC3=CC=C(F)C=C3F)N(C)N=C2C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2423

>  <W2 Pf proliferation inhibition EC50 uM>
0.356

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
78.25

>  <Powder data?>
Yes

>  <IFI value>
0.024590164

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4529
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -3.5723    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -4.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1061   -2.9738    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2376    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0012   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4529

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC=C4F)C(=O)OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0347

>  <W2 Pf proliferation inhibition EC50 uM>
0.0332

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.32

>  <Powder data?>
Yes

>  <IFI value>
0.047619048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-453
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  2  9  4  0  0  0  0
  6 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-453

>  <JC_XSMILES>
CC1=CC(C)=C(C(C)=C1)S(=O)(=O)NCC2=CC=C(Cl)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
6.59

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.91

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4531
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -3.5724   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  7 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4531

>  <JC_XSMILES>
NNC(=O)CNC(C1=CC=CC=C1)C2=CC(Br)=CC=C2NC(=O)C3=CC=CC=C3Br

>  <PF proliferation inhibition 3D7 EC50 uM>
0.342

>  <W2 Pf proliferation inhibition EC50 uM>
0.453

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.030769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4533
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 10 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
  7 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4533

>  <JC_XSMILES>
CC(C)NC(=O)C1=CC=C(OC2CCN(CC2)CC3CCCCC3)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.476

>  <W2 Pf proliferation inhibition EC50 uM>
0.2978

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
65.9

>  <Powder data?>
Yes

>  <IFI value>
0.028169014

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4534
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8653    0.4014    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4534

>  <JC_XSMILES>
COC1=CC(OC)=CC(=C1)C(=O)NCc2n[nH]c(=S)n2C3=CC=CC(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.565

>  <W2 Pf proliferation inhibition EC50 uM>
0.45

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011494253

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4536
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -1.3144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 23 29  4  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 33 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4536

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC(Cl)=C4)C(=O)OC5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2013

>  <W2 Pf proliferation inhibition EC50 uM>
0.0758

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.85

>  <Powder data?>
Yes

>  <IFI value>
0.082352941

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4537
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    4.4025    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1170    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8315    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5459    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2604    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9749    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9749    1.3607    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6894    0.1232    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.4038    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4038    1.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1183    1.7732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8328    1.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8328    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1183    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1183   -0.7018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7857   -1.1867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5704   -0.9317    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1835   -1.4838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6314   -2.0969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7355   -0.8707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7966   -2.0358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5812   -1.7809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3658   -1.5259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.8361   -2.5655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3262   -0.9963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5308   -1.9713    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.9433   -2.6858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5308   -3.4003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7058   -3.4003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2933   -4.1147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2933   -2.6858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7058   -1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4509   -1.1867    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 16 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
 32 33  4  0  0  0  0
 15 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4537

>  <JC_XSMILES>
CCCCCC(=O)OC1=CC=CC=C1C2=C(NC(C)(C)CC(C)(C)C)N3C=CC(C)=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.703

>  <W2 Pf proliferation inhibition EC50 uM>
0.0448

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.046728972

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4538
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    4.5164    4.2059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1039    3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5164    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3414    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7539    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3414    1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5164    1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1039    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4539    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7179    2.0361    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769    2.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2485    3.2846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8616    2.7326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4538

>  <JC_XSMILES>
CCC1CCCCN1S(=O)(=O)C2=CC(Br)=CC3=C2N(CC3)C(=O)C4CC4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.844

>  <W2 Pf proliferation inhibition EC50 uM>
0.448

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4539
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  1  0  0  0  0
 10 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4539

>  <JC_XSMILES>
CCCNC(=O)N1CCC2(CC1)CC(=O)C3=CC(C)=CC=C3O2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.87

>  <W2 Pf proliferation inhibition EC50 uM>
0.448

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4541
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    8.4669   -6.6616    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -5.0116    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -7.4866    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -6.2491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -7.4866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8476   -7.9715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926   -8.7562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676   -8.7562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -7.9715    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
  4 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4541

>  <JC_XSMILES>
ClC1=CC(=CC=C1OC2CCN(CC2)CC3CCCCC3)C(=O)NCC4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.719

>  <W2 Pf proliferation inhibition EC50 uM>
0.0446

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4542
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    6.3235    0.2277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -1.0098    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -1.0098    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -2.2473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5620   -2.7322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3467   -2.4773    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3071   -3.5169    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4821   -3.5169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9972   -4.1843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2272   -2.7322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4425   -2.4773    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6975   -1.6927    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1876   -3.2619    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6579   -2.2224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0448   -2.7744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2602   -2.5195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0887   -1.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7018   -1.1605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4864   -1.4154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5302   -0.3535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7456   -0.0985    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433    0.1986    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9718    1.0055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5849    1.5576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3695    1.3026    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5410    0.4956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9279   -0.0564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9826    1.8546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8111    2.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4242    3.2137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2527    4.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2088    2.9587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3803    2.1517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7672    1.5997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9388    0.7927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
  6 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
 27 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 30 36  4  0  0  0  0
 36 37  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   9
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4542

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC(C)=C1S(=O)(=O)N2CCCC(C2)C(=O)N3CCN(CC3)C4=CC(C)=CC=C4C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2314

>  <W2 Pf proliferation inhibition EC50 uM>
0.367

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>82.34

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4546
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    0.2498   -4.0609    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6707    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9256    2.2518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6285    0.8541    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 10 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  8 23  4  0  0  0  0
 19 23  4  0  0  0  0
M  CHG  1  10   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4546

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C2=C[N+](CC3=CC=CC=C3Cl)=C4CCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.784

>  <W2 Pf proliferation inhibition EC50 uM>
0.384

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>87.03

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4547
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    2.8340    0.2762    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8340   -0.5488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5014   -1.0338    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2465   -1.8184    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4215   -1.8184    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.0338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -0.7788    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2637    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -0.7788    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    0.0058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830    0.6732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526    1.4269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034    0.5870    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884    1.2544    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3088    1.1682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7938    1.8357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6142    1.7494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0992    2.4169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7636    3.1705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9431    3.2568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6076    4.0104    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.4582    2.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    0.0058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119    0.6732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763    1.4269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613    2.0944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817    2.0081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173    1.2544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324    0.5870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 14 13  1  4  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 16 22  4  0  0  0  0
 10 23  4  0  0  0  0
  7 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4547

>  <JC_XSMILES>
NC1=NON=C1N2N=NC(C(=O)NN=CC3=CC=CC(Cl)=C3)=C2C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.427

>  <W2 Pf proliferation inhibition EC50 uM>
0.441

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4554
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    4.8395   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2520   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  4  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  1  6  4  0  0  0  0
  4  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 15 20  4  0  0  0  0
 16 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4554

>  <JC_XSMILES>
C1=CC=C(C=C1)C2=CC=NC3=C2C=CC4=C(C=CN=C34)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.329

>  <W2 Pf proliferation inhibition EC50 uM>
0.43

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.13740458

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4559
  Mrv1591402191617072D          

 35 40  0  0  0  0            999 V2000
    3.1740   -4.9012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4289   -4.1166    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9440   -3.4491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190   -3.4491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065   -2.7346    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190   -2.0202    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065   -1.3057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8860   -1.2195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0420   -0.5520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1039    0.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5519    1.0172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8069    1.8018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6138    1.9734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1659    1.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9109    0.5756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4289   -2.7817    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -3.0366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9280   -2.6241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6425   -3.0366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6425   -3.8616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9280   -4.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -3.8616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3670   -5.0727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1121   -5.8573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3051   -6.0289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7530   -5.4158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0080   -4.6311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8150   -4.4596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  5  4  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
  7 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  3 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
  2 29  4  0  0  0  0
 24 29  4  0  0  0  0
  1 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4559

>  <JC_XSMILES>
C(N1C(NN=NC2=NC3=CC=CC=C3N2CC4=CC=CC=C4)=NC5=CC=CC=C15)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0854

>  <W2 Pf proliferation inhibition EC50 uM>
0.0819

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.18

>  <Powder data?>
Yes

>  <IFI value>
0.060344828

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-456
  Mrv1591402191617072D          

 26 30  0  0  1  0            999 V2000
    3.8353   -6.8814    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3035   -6.2507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4913   -6.3959    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5838   -5.4748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0519   -4.8441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3322   -4.0682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1444   -3.9229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6762   -4.5536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3959   -5.3296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4247   -3.1470    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.2368   -3.0018    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5171   -2.2259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9853   -1.5952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2655   -0.8192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0777   -0.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6095   -1.3047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4216   -1.1595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9534   -1.7902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6731   -2.5662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8610   -2.7114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3292   -2.0807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1731   -1.7404    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5218   -1.2340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8390   -1.6970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0683   -2.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8928   -2.5163    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
 10  7  1  1  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 16 21  4  0  0  0  0
 22 13  1  0  0  0  0
 22 23  1  1  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 26 25  1  1  0  0  0
 26 10  1  0  0  0  0
 26 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-456

>  <JC_XSMILES>
OC(=O)C1=CC=C(C=C1)[C@@H]2NC3=C(C=CC4=CC=CC=C34)[C@@H]5C=CC[C@H]25

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.343

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4563
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  2  0  0  0  0
  6 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
  3 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4563

>  <JC_XSMILES>
COC1=CC=C(NC(C)=C2C(=O)C3=CC=CC=C3C2=O)C(OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.268

>  <W2 Pf proliferation inhibition EC50 uM>
0.426

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4564
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.8018   -4.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498   -4.0609    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076    1.3686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3444    0.7556    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473    2.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8543    2.3248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1092    3.1094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5572    3.7225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498    3.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8121    4.5071    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.6191    4.6787    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.2601    5.1202    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 11 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
  9 28  4  0  0  0  0
 24 28  4  0  0  0  0
M  CHG  3  11   1  21   1  22  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4564

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C[N+](CC(=O)C3=CC=C(C=C3)[N+]([O-])=O)=C4CCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.518

>  <W2 Pf proliferation inhibition EC50 uM>
0.426

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.025

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4567
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.8866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2032   -1.9416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -2.9812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6486   -3.6486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4691   -3.5624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9540   -4.2298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -4.9835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7980   -5.0697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3130   -4.4023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -2.9812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8538   -3.6486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1893   -4.4023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7044   -5.0697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8839   -4.9835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5484   -4.2298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0333   -3.5624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2991   -1.9416    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.5541   -1.1570    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0442   -2.7262    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5145   -1.6867    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3430   -0.8797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4417   -0.6247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6132    0.1822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.7343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7845    0.4793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9561   -0.3276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1716    1.5412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3431    2.3482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6354    1.7128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9786    1.3697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 16 23  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 31 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 34 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4567

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N(C2=CC=CC=C2)C(C3=CC=CC=C3)=C1S(=O)(=O)NC4=CC=C(C=C4)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.696

>  <W2 Pf proliferation inhibition EC50 uM>
0.425

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.030927835

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4568
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    5.0013    0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1763   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.8263   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4568

>  <JC_XSMILES>
ClC(Cl)(Cl)C(=O)NC1=CC=CC=C1N2CCN(CC2)C(=O)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.538

>  <W2 Pf proliferation inhibition EC50 uM>
0.425

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4569
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
    0.4507    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -2.8414    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6329   -3.6421    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4614   -4.4490    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1759   -4.8615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2621   -5.6820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0158   -6.0176    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1020   -6.8381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4346   -7.3230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8557   -7.1736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0272   -7.9806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8477   -8.0668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1833   -7.3131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5702   -6.7611    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7890   -4.3095    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5960   -4.4810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8509   -5.2657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6579   -5.4372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2099   -4.8241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9550   -4.0395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5070   -3.4264    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.1480   -3.8679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 22 26  4  0  0  0  0
 17 27  4  0  0  0  0
 14 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 28 34  4  0  0  0  0
  7 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
  6 37  4  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 36 41  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4569

>  <JC_XSMILES>
CCOC(=O)C1=C(NC(=O)C(C)SC2=NN=C(CNC(=O)C3=CC=CO3)N2C4=CC=CC(Cl)=C4)SC5=C1CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.424

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012195122

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4570
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    3.8989   -4.4309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919   -4.6024    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  1  0  0  0  0
 12 17  4  0  0  0  0
  9 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
 24 25  4  0  0  0  0
 18 25  4  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4570

>  <JC_XSMILES>
COC1=CC=C(NC2=C(C(=O)C3=CC=CC=C23)C4=CC=C(OC)C=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.437

>  <W2 Pf proliferation inhibition EC50 uM>
0.423

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047619048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4573
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    7.0685    4.3282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2560    4.1850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7257    4.8169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0079    5.5922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4776    6.2242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9133    4.6737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6311    3.8984    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1614    3.2664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8792    2.4912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3489    1.5727    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5365    2.9799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8186    3.7552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.8085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 19 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4573

>  <JC_XSMILES>
CCC(CC)CN1CCC(O)(CC1)C2=CC=C3OC(=CC3=C2)C(=O)NC4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.344

>  <W2 Pf proliferation inhibition EC50 uM>
0.36

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>85.85

>  <Powder data?>
Yes

>  <IFI value>
0.034482759

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4574
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    3.9855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    4.8105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3529    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3529    7.2855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    7.6980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    7.2855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  2 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 18 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4574

>  <JC_XSMILES>
OC(CN1CCN(CC1)CC2=CC=CC=C2)CN3C4=CC=C(Cl)C=C4C5=CC(Cl)=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2178

>  <W2 Pf proliferation inhibition EC50 uM>
0.0657

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.68

>  <Powder data?>
Yes

>  <IFI value>
0.011494253

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4576
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
  8 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
  7 23  1  0  0  0  0
 23 24  2  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4576

>  <JC_XSMILES>
CC1=CC=C(NC2=C(N3CCCCC3)C(=O)C4=CC=CC=C4C2=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.131

>  <W2 Pf proliferation inhibition EC50 uM>
0.0775

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.54

>  <Powder data?>
Yes

>  <IFI value>
0.0390625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4578
  Mrv1591402191617072D          

 24 28  0  0  0  0            999 V2000
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1369   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6218   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4468   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8593   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6798   -1.4986    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513   -2.3056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1369   -2.7181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5238   -2.1661    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.6050   -2.6412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2725   -2.1563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0261   -2.4918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1124   -3.3123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4449   -3.7972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6912   -3.4617    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1369   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  1  9  1  0  0  0  0
  6 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 11 24  4  0  0  0  0
  5 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4578

>  <JC_XSMILES>
C1OC2=CC3=C(C=C2O1)N=C(NC4=NC(=CS4)C5=CC=CC=N5)S3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.65

>  <W2 Pf proliferation inhibition EC50 uM>
0.417

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.177777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-458
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    5.6091   -1.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -2.6598    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2765   -3.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0216   -3.9294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1966   -3.9294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9416   -3.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -2.8898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9855   -2.0828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2009   -1.8279    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0293   -1.0209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2447   -0.7660    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0732    0.0410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6863    0.5930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5147    1.4000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1278    1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7301    1.6549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5586    2.4619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7740    2.7168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6024    3.5238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1822    3.7788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3537    4.5857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2594    5.1378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0440    4.8828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2155    4.0758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4709    0.3381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0840    0.8901    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9125    1.6971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5256    2.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3540    3.0561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9671    3.6081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7517    3.3532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9233    2.5462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3102    1.9942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6424   -0.4689    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  2  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 13 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
 25 34  4  0  0  0  0
 10 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-458

>  <JC_XSMILES>
CN1CCCC1CCNC2=NC=C(C(=O)NCCC3=CC=CC=C3)C(NCC4CCCCC4)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.598

>  <W2 Pf proliferation inhibition EC50 uM>
1.342

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009615385

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4580
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175   -4.4158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483   -3.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878   -3.3762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489   -2.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227   -3.3151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8913    2.8744    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 13 18  4  0  0  0  0
 11 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 28 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4580

>  <JC_XSMILES>
CC(C)(C)CC(C)(C)NC1=C(N=C2C=CC=CN12)C3=CC=CC=C3OC(=O)C4=CC=CC(Cl)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.629

>  <W2 Pf proliferation inhibition EC50 uM>
0.0416

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.047169811

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4581
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 19 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4581

>  <JC_XSMILES>
CCCCC1=CC=C(C=C1)C(=O)N(C)CCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.427

>  <W2 Pf proliferation inhibition EC50 uM>
0.0416

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.031578947

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4582
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 12 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 11 27  1  0  0  0  0
 27 28  2  0  0  0  0
  9 29  4  0  0  0  0
 29 30  4  0  0  0  0
  6 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4582

>  <JC_XSMILES>
CCOC(=O)C1=CC=C(NC2=C(N3CCCCC3)C(=O)C4=CC=CC=C4C2=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2434

>  <W2 Pf proliferation inhibition EC50 uM>
0.334

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>80.46

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4590
  Mrv1591402191617072D          

 15 16  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4412   -3.0584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.6417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2745   -3.0584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 12 15  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4590

>  <JC_XSMILES>
FC1=CC=CC=C1NNC(=O)C2CCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.49

>  <W2 Pf proliferation inhibition EC50 uM>
0.0406

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.034482759

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4591
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -1.4924    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8419   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -0.1576    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
  6 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 14 26  4  0  0  0  0
 26 27  2  0  0  0  0
  2 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  25
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4591

>  <JC_XSMILES>
CC(NC(=S)N(CC1=CC=CO1)CC2=CC3=CC4=C(OCO4)C=C3NC2=O)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.372

>  <W2 Pf proliferation inhibition EC50 uM>
0.405

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.05785124

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4597
  Mrv1591402191617072D          

 39 44  0  0  0  0            999 V2000
    1.5925   -1.3668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    1.1082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771    1.3632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320    2.1478    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8620    0.6957    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771    0.0283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320   -0.7563    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6870    0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0995   -0.0188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9245   -0.0188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3370    0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9245    1.4102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0995    1.4102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3370    2.1247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7495    2.8391    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.0515    1.7122    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.6225    2.5372    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    2.3457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    2.7582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6717    0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1533    0.6957    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    1.1082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510    1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    1.1082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799    1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799    2.3457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    2.7582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510    2.3457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510   -0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510   -0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654   -1.3668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799   -0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799   -0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
  5 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  1  0  0  0  0
  3 24  1  0  0  0  0
 24 25  2  0  0  0  0
 21 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 26 33  2  0  0  0  0
  3 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4597

>  <JC_XSMILES>
CCC12C3C(C(=O)N(C3=O)C4=CC=CC(=C4)C(F)(F)F)C(CC)(C1=O)C(C5=CC=CC=C5)=C2C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
2.409

>  <W2 Pf proliferation inhibition EC50 uM>
0.401

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4598
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
    3.2789    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7179   -1.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4630   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0150   -2.6088    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3440   -2.1672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8960   -1.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6411   -0.7695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1659   -0.5980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4208    0.1866    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513   -4.9500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    7.5658   -5.3625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    6.1368   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  1  0  0  0  0
  4 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 31 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  2  0  0  0  0
M  CHG  2  34   1  35  -1
M  STY  1   1 DAT
M  SAL   1  1   5
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4598

>  <JC_XSMILES>
OC1=NC(=NC2=C1N=NN2CC3=C(F)C=CC=C3Cl)C4CCN(CC4)C(=O)C5=CC=C(C=C5)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2101

>  <W2 Pf proliferation inhibition EC50 uM>
0.401

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.078947368

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4599
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -9.4875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.5901   -9.7895    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.4151   -8.3605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 15 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 30 33  1  0  0  0  0
  7 34  1  0  0  0  0
  2 34  1  0  0  0  0
M  CHG  2  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4599

>  <JC_XSMILES>
CC1CC(C)CN(CCCNC2=CC=C(C=C2[N+]([O-])=O)C(=O)NC3=CC=C(C=C3)C(F)(F)F)C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1187

>  <W2 Pf proliferation inhibition EC50 uM>
0.401

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4601
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3848   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8545   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 14 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 22 29  4  0  0  0  0
 29 30  4  0  0  0  0
 12 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4601

>  <JC_XSMILES>
CCCC(=O)N1CCN(CC1)C2=NC(CC3=CC=CC=C3)=C4COC(C)(C)CC4=C2C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.324

>  <W2 Pf proliferation inhibition EC50 uM>
0.363

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>90.88

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4602
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3441   -2.8361    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2822   -1.8800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9638    0.0501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5159   -0.5630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1034   -1.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2964   -1.1059    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
  7 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 24 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4602

>  <JC_XSMILES>
CC1=C(C)C2=CC(=CC=C2N1CC3=CC=C(F)C=C3)C(=O)NCC4=CC=CO4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0782

>  <W2 Pf proliferation inhibition EC50 uM>
0.399

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4604
  Mrv1591402191617072D          

 42 48  0  0  0  0            999 V2000
   -5.1212   -3.5558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -2.8414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0087   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0087   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6731   -6.4529    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2862   -7.0049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2862   -7.8299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.0007   -8.2424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.7152   -7.8299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.7152   -7.0049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.0007   -6.5924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8292   -5.7855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
  2 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 23 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 31 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 36 41  4  0  0  0  0
 41 42  4  0  0  0  0
 34 42  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  42
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4604

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)C2=NC3=CC=CC=C3N2)C4=CC=CC(=N4)C(=O)NC5=CC=C(C=C5)C6=NC7=CC=CC=C7N6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1208

>  <W2 Pf proliferation inhibition EC50 uM>
0.1263

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
31.72

>  <Powder data?>
Yes

>  <IFI value>
0.111111111

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4605
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -1.4604    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -2.3215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5410   -3.0752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3615   -2.9890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5330   -2.1820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8185   -1.7695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4662   -1.0582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2545   -1.3014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5559   -2.0693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1434   -2.7838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3276   -2.9068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7229   -2.3456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
  6 14  4  0  0  0  0
 14 15  4  0  0  0  0
  4 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 20 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4605

>  <JC_XSMILES>
C=CCN1N=C(C(=O)N2CCCC2)C3=C1CCC(C3)N4CCCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.772

>  <W2 Pf proliferation inhibition EC50 uM>
0.0398

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.024096386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4606
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    0.9355    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9355    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6645    0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
  7 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4606

>  <JC_XSMILES>
CCC(C)NCC(O)(C1=CC=C(Cl)C=C1)C2=CC=C(Cl)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.639

>  <W2 Pf proliferation inhibition EC50 uM>
0.1843

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
46.33

>  <Powder data?>
Yes

>  <IFI value>
0.013157895

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4607
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    1.3222    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    2.0009    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.1759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -3.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1661   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9866   -3.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -2.9774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8372   -2.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1728   -1.5563    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0168   -2.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4682   -1.7287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  1  0  0  0  0
 14 24  4  0  0  0  0
 11 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4607

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2=CSC(NC3=CC=CC(Cl)=C3C)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
8.21

>  <W2 Pf proliferation inhibition EC50 uM>
0.355

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>89.3

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4609
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2822   -1.8800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  2  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
 12 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4609

>  <JC_XSMILES>
O=C(N1CCCCC1)N2N=NC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
1.306

>  <W2 Pf proliferation inhibition EC50 uM>
0.396

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.033333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4611
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    2.1434   -4.5375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
  4 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4611

>  <JC_XSMILES>
ClC1=CC(=CC=C1OC2CCN(CC2)CC3CCCCC3)C(=O)NCC#C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.499

>  <W2 Pf proliferation inhibition EC50 uM>
0.396

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.097222222

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4615
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2630    0.1043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3022   -5.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 23 24  4  0  0  0  0
 17 24  4  0  0  0  0
 15 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  4  0  0  0  0
 25 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4615

>  <JC_XSMILES>
CCC1CCCCN1C(=O)C2CC(=O)N(C2C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.387

>  <W2 Pf proliferation inhibition EC50 uM>
0.394

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4616
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -0.6941   -1.5205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6941   -2.3455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0204   -2.7580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7349   -2.3455    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0204   -3.5830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6941   -3.9955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4085   -3.5830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4085   -2.7580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1230   -2.3455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1230   -1.5205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4085   -1.1080    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8375   -1.1080    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5191   -1.5727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3075   -1.3296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6089   -0.5616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1964    0.1529    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3806    0.2758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7758   -0.2853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6611    0.8345    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4838    0.7729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9486    1.4545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5906    2.1978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7679    2.2595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3032    1.5778    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4805    1.6395    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.0157    0.9578    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.1225    2.3828    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0553    2.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5201    3.5611    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3737    3.3442    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7370    2.4147    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 12 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
 22 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 28 31  1  0  0  0  0
M  CHG  2  25   1  26  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4616

>  <JC_XSMILES>
CC1=C(Cl)C=CC=C1NC(=S)N2CCCN(CC2)C3=CC=C(C=C3[N+]([O-])=O)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2538

>  <W2 Pf proliferation inhibition EC50 uM>
0.2023

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
51.44

>  <Powder data?>
Yes

>  <IFI value>
0.025

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4617
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    1.4243   -1.3895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8112   -1.9415    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8974   -2.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -2.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0408   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7553   -2.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4698   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1842   -2.7620    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8987   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8987   -3.9995    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6132   -2.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6132   -1.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3277   -1.5245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0421   -1.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0421   -2.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3277   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7566   -3.1745    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    9.4711   -2.7620    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    8.7566   -3.9995    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3277   -0.6995    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    8.0421   -0.2870    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    6.6132   -0.2870    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1437   -3.0975    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4083   -2.4844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2288   -2.5707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5643   -3.3244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3848   -3.4106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8697   -2.7432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5342   -1.9895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7137   -1.9032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0042   -1.7700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3313   -1.0163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1518   -0.9301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4874   -0.1764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0025    0.4910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1820    0.4048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -0.3489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 14 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
  3 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 25 32  4  0  0  0  0
  2 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
M  CHG  4  18   1  19  -1  21   1  22  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4617

>  <JC_XSMILES>
CN1C(SCCCCNC(=O)C2=CC(=CC(=C2)[N+]([O-])=O)[N+]([O-])=O)=NC(C3=CC=CC=C3)=C1C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.411

>  <W2 Pf proliferation inhibition EC50 uM>
0.0337

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.57

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4618
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8171    1.7895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1527    2.5432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9732    2.4570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  7 19  4  0  0  0  0
 14 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4618

>  <JC_XSMILES>
CN(C)CCNC1=C2CCCC2=NC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.579

>  <W2 Pf proliferation inhibition EC50 uM>
0.2415

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
61.42

>  <Powder data?>
Yes

>  <IFI value>
0.022988506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4619
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1759    4.3338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9605    4.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9605    3.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1759    2.9989    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 29 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4619

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.667

>  <W2 Pf proliferation inhibition EC50 uM>
0.0393

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4622
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    0.6490   -2.2790    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0390   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6043   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9943   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5597    0.5775    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8189   -0.0980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2535   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0781   -0.7735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6108   -0.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4141    0.6578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3745   -0.4553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3140   -1.2781    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -1.4747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1228   -2.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2982   -2.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8636   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0758   -0.0207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0500    0.8039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8028   -0.4107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5040    0.0239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2310   -0.3661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2568   -1.1907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5556   -1.6253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8285   -1.2353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  2  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
  7 16  4  0  0  0  0
 11 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4622

>  <JC_XSMILES>
CC1=CC(=O)OC2=C3C(C)=C(OC3=CC=C12)C(=O)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.441

>  <W2 Pf proliferation inhibition EC50 uM>
0.392

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.055045872

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4623
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
    6.4296    1.0622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9950    0.3610    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1704    0.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7804    1.1137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9558    1.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5212    0.4383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9112   -0.2887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7358   -0.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4766   -0.9900    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8666   -1.7170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6912   -1.7427    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4319   -2.4182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8219   -3.1452    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3873   -3.8465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6992   -4.6103    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0691   -5.1429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0434   -5.9675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3164   -6.3575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6151   -5.9229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6409   -5.0983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3679   -4.7083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645   -3.9070    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6520   -0.9642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7698   -1.7808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8683   -1.2220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2620   -0.2372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4608   -0.0406    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4002    0.7822    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1640    1.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3606    1.8953    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6966    0.4640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
  9 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  2  0  0  0  0
 29 31  4  0  0  0  0
  6 31  1  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4623

>  <JC_XSMILES>
COC1=CC=C2C(=C1)N(C(=O)CSC3=NC4=CC=CC=C4O3)C(C)(C)c5ssc(=S)c25

>  <PF proliferation inhibition 3D7 EC50 uM>
0.345

>  <W2 Pf proliferation inhibition EC50 uM>
0.392

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011494253

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4624
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  4  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 16 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 14 25  4  0  0  0  0
 12 26  4  0  0  0  0
 26 27  2  0  0  0  0
 26 28  4  0  0  0  0
 10 28  4  0  0  0  0
 28 29  1  0  0  0  0
  6 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4624

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N=c2sc(=CC3=CC(CC=C)=C(O)C(OC)=C3)c(=O)n2C1C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.391

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012345679

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4627
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489    0.8152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227    1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    1.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175    3.0199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483    2.5100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 12 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
 11 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4627

>  <JC_XSMILES>
CC(=O)OC1=CC=CC=C1C2=C(NC(C)(C)CC(C)(C)C)N3C=CC=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.489

>  <W2 Pf proliferation inhibition EC50 uM>
0.0367

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>9.44

>  <Powder data?>
No

>  <IFI value>
0.037735849

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4630
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -4.2962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -4.2703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -4.2703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  6  5  1  4  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
  5 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
  3 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4630

>  <JC_XSMILES>
COC1=CC(C=NNC2=NC3=CC=CC=C3N2)=CC(OC)=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1755

>  <W2 Pf proliferation inhibition EC50 uM>
0.339

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
87.47

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4634
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -1.9317   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1067   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5433   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5983   -3.3875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  4  0  0  0  0
  8 21  4  0  0  0  0
 21 22  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4634

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=NN3C(O)=C4CCCCC4=NC3=C2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2558

>  <W2 Pf proliferation inhibition EC50 uM>
0.384

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.109090909

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4635
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 13 12  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 15 22  4  0  0  0  0
 22 23  1  0  0  0  0
 11 24  4  0  0  0  0
  6 24  4  0  0  0  0
 24 25  4  0  0  0  0
  3 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4635

>  <JC_XSMILES>
COC1=CC=C2N=C(C)C=C(NN=CC3=CC=CC(OC)=C3O)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02507

>  <W2 Pf proliferation inhibition EC50 uM>
0.02348

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.12

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4640
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    6.2102    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4640

>  <JC_XSMILES>
CSC1=CC=CC=C1CN2CCC3=C(C2)SC(=N3)N4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.369

>  <W2 Pf proliferation inhibition EC50 uM>
0.0381

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4642
  Mrv1591402191617072D          

 44 49  0  0  0  0            999 V2000
   -3.8837    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    1.7771    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4628    0.9521    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8128    0.9521    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
 20 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 18 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 30 33  1  0  0  0  0
 11 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
 42 43  1  0  0  0  0
 35 44  4  0  0  0  0
  9 44  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4642

>  <JC_XSMILES>
CC1=CC=CC=C1OC2=CC(NC(=O)C3=NN4C(CC(NC4=C3)C5=CC=CC=C5)C(F)(F)F)=CC(OC6=CC=CC=C6C)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.359

>  <W2 Pf proliferation inhibition EC50 uM>
0.38

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.008064516

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4647
  Mrv1591402191617072D          

 19 19  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
  4 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4647

>  <JC_XSMILES>
CC1=CC(=CC(=C1C)S(=O)(=O)NCCO)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.377

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.029850746

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4648
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 19 28  4  0  0  0  0
 15 28  4  0  0  0  0
 28 29  2  0  0  0  0
 18 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 30 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4648

>  <JC_XSMILES>
CCN1CCN(CC1)CC2=C(O)C=CC3=C2OC(=C(OC4=CC=CC=C4Br)C3=O)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.387

>  <W2 Pf proliferation inhibition EC50 uM>
0.377

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4649
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -0.2934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  2  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 17 25  4  0  0  0  0
 25 26  2  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 14 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 27 31  4  0  0  0  0
 31 32  1  0  0  0  0
 30 33  1  0  0  0  0
 33 34  2  0  0  0  0
 33 35  1  0  0  0  0
 35 36  1  0  0  0  0
 35 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4649

>  <JC_XSMILES>
CCOC1=CC=CC=C1NC(=O)CN2C(=O)N(CC3=CC=CC=C3)C(=O)C4=C2SC(=C4C)C(=O)N(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.883

>  <W2 Pf proliferation inhibition EC50 uM>
0.377

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-465
  Mrv1591402191617072D          

 37 39  0  0  0  0            999 V2000
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3427   -4.9455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5357   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1232   -4.4025    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6753   -3.7894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5037   -2.9825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2809   -2.7275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4524   -1.9206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1607   -1.3685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0108   -0.5616    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.9453   -1.6235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5584   -1.0714    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.1168   -2.4304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2002   -5.8707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1354   -6.6244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5535   -5.5351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9539   -6.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -5.7750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.4467   -6.0770    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717   -4.6480    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 14 21  4  0  0  0  0
 11 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  4 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 31 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 34 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-465

>  <JC_XSMILES>
CC(C)N(CC(=O)NC1=CC(=NN1C2=CC=C(Cl)C(Cl)=C2)C(C)(C)C)C(=O)C3=CC=C(C=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.845

>  <W2 Pf proliferation inhibition EC50 uM>
1.326

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019047619

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4651
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
  6 11  4  0  0  0  0
  3 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 12 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4651

>  <JC_XSMILES>
OC1=C(C=CC2=CC=CN=C12)C(NC(=O)C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.533

>  <W2 Pf proliferation inhibition EC50 uM>
0.376

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4652
  Mrv1591402191617072D          

 18 18  0  0  0  0            999 V2000
    4.2868    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  5  4  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
  7 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4652

>  <JC_XSMILES>
NC(=S)NN=CC(=NNC(N)=S)C1=CC=CC=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0481

>  <W2 Pf proliferation inhibition EC50 uM>
0.0376

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.11023622

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4653
  Mrv1591402191617072D          

 29 32  0  0  1  0            999 V2000
    0.9051   -4.3827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5151   -3.6557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9497   -2.9545    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5597   -2.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2649   -2.2017    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9943   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6043   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0390   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8636   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2982    0.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1228    0.5517    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5127   -0.1753    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.3140   -0.3719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3745   -1.1947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6108   -1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0781   -0.8765    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2535   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8189   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5574    1.2530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1674    1.9800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4266    2.6554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8612    3.3567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4712    4.0837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8166    1.9284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3820    1.2272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6412    1.9027    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.0312    1.1757    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    6.0758    2.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 11 10  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  1  1  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 16 15  1  1  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
  6 18  4  0  0  0  0
 11 19  1  1  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 25 26  4  0  0  0  0
 19 26  4  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  2  0  0  0  0
M  CHG  2  27   1  28  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4653

>  <JC_XSMILES>
CCOC(=O)C1=CC=C2N[C@H]([C@H]3CC=C[C@H]3C2=C1)C4=CC=C(OC)C(=C4)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.39

>  <W2 Pf proliferation inhibition EC50 uM>
0.376

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4656
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -1.0079    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7780    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2629    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7780   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 10 21  4  0  0  0  0
 17 21  4  0  0  0  0
  8 22  4  0  0  0  0
  4 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4656

>  <JC_XSMILES>
CCOC1=CC=CC(NC2=C3CCCC3=NC4=NC=NN24)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.597

>  <W2 Pf proliferation inhibition EC50 uM>
0.374

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4657
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
 12 11  1  4  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4657

>  <JC_XSMILES>
OC1=CC=C2C=CC=CC2=C1C=NNC(=O)C3=CC=CN=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.875

>  <W2 Pf proliferation inhibition EC50 uM>
0.373

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.147058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4658
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -1.3144    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 16 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 14 28  1  0  0  0  0
 23 28  4  0  0  0  0
 15 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 29 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4658

>  <JC_XSMILES>
COC1=CC(Cl)=C(C)C=C1NC(=O)C2C(N(CC(C)C)C(=O)C3=CC=CC=C23)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.578

>  <W2 Pf proliferation inhibition EC50 uM>
0.373

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.090909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4660
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    4.0992   -3.3499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0992   -4.1749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7666   -4.6598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5117   -5.4445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6867   -5.4445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4317   -4.6598    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9966   -6.1119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6611   -6.8656    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8171   -6.0257    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3020   -6.6931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1270   -6.6931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3820   -7.4777    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1666   -7.7327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3381   -8.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1227   -8.7946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2943   -9.6016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6812  -10.1536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8527  -10.9606    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.8965   -9.8986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7250   -9.0917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9404   -8.8367    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.7145   -7.9627    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0471   -7.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  4  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 12 22  4  0  0  0  0
 22 23  4  0  0  0  0
 10 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4660

>  <JC_XSMILES>
CC1=CC(=NO1)C(=O)NC2=CN(CC3=CC=C(Cl)C=C3Cl)N=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.62

>  <W2 Pf proliferation inhibition EC50 uM>
0.371

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4663
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.5597   -2.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9943   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6043   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0390   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6490    0.6290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8636   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2982    0.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9082    1.3045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0836    1.3302    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3428    2.0057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9528    2.7327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3874    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2120    3.4082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1674    1.9800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1228    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0049    1.3683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9064    0.8095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -0.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0781   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6108   -1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4141   -2.3078    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3745   -1.1947    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3140   -0.3719    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2535   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8189   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  7 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  2  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 20 25  1  0  0  0  0
  6 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4663

>  <JC_XSMILES>
CC1=CC(C)=C2N(C(=O)C3=CC=CC=C3)C(C)(C)C4=C(C(=S)SS4)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.523

>  <W2 Pf proliferation inhibition EC50 uM>
0.37

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4666
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    0.5657   -3.7429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2801   -4.1554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2801   -4.9804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9946   -5.3929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9946   -6.2179    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2801   -6.6304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -6.2179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -5.3929    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1488   -6.6304    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8633   -6.2179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6170   -6.5535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1690   -5.9404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7565   -5.2259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9495   -5.3974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2801   -7.4554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9476   -7.9403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6926   -8.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8676   -8.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3827   -9.3924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6127   -7.9403    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7091   -6.6304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7091   -7.4554    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4235   -6.2179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1380   -6.6304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8525   -6.2179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8525   -5.3929    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5670   -6.6304    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2814   -6.2179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3677   -5.3974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1746   -5.2259    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5871   -5.9404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4076   -6.0266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0351   -6.5535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
  6 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 15 20  4  0  0  0  0
  5 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4666

>  <JC_XSMILES>
CCCCN(C(C(=O)NC1CCCC1)C2=CC=C(C)O2)C(=O)CCC(=O)NC3=NOC(C)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02225

>  <W2 Pf proliferation inhibition EC50 uM>
0.0369

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018181818

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-467
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -0.0926   -1.4091    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 Si  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4914   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9039   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4914   -3.1894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664   -3.1894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1914   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6336   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0461   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6336   -1.7606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1914   -1.7606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7143    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  4 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  4 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  2 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-467

>  <JC_XSMILES>
O=C(O[Si](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.322

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4675
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
    4.7674    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2243   -1.1567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1347   -1.5983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6867   -2.2114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4937   -2.0399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7486   -1.2553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5556   -1.0837    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.1966   -0.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.7556    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4515    0.1425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2585    0.3140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8105   -0.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6175   -0.1276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8724    0.6570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6794    0.8286    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.3204    1.2701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5134    1.0986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 13 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
 21 31  4  0  0  0  0
  9 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4675

>  <JC_XSMILES>
CN1CCC2=C(C1)SC3=C2C(=O)N(C4=CC=CC(Cl)=C4)C(SCC5=CC=C(Cl)C=C5)=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.054

>  <W2 Pf proliferation inhibition EC50 uM>
0.363

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.115384615

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4676
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801   -1.0164    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2426   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6551   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2426   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769   -1.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8839   -1.4811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4359   -2.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1810   -2.8788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3740   -3.0504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8220   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  2  0  0  0  0
  3  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  5 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 18 30  4  0  0  0  0
 15 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4676

>  <JC_XSMILES>
CN1C(=O)N(CC2=CC=CC=C2)C(=O)C3=C1N=C(SCC(=O)NC4=CC=CC=C4)N3CC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.854

>  <W2 Pf proliferation inhibition EC50 uM>
0.362

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4677
  Mrv1591402191617072D          

 27 31  0  0  0  0            999 V2000
    3.6092    4.6002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7778    3.7927    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5615    3.5349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1766    4.0847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9603    3.8269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1289    3.0193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5138    2.4695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7301    2.7273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6824    1.6619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4832    1.4634    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.8273    0.7136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6509    0.7600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1029    0.0698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7312   -0.6667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9076   -0.7131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4556   -0.0229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6480   -0.1915    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0126    0.3348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0279    1.1596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2482    1.4291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0079    2.2183    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7510    0.7708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9290    0.6998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5795   -0.0475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0520   -0.7239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8739   -0.6529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2234    0.0944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
  9 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  1  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4677

>  <JC_XSMILES>
COC1=CC=CC(=C1)C2SC3=CC=CC=C3NC4=C2C(=O)C5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.577

>  <W2 Pf proliferation inhibition EC50 uM>
0.362

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4678
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    1.2375    7.6485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    6.8235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230    6.4110    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    6.4110    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    5.5860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664    5.1735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664    4.3485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    3.9360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    4.3485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    5.1735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    3.1110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2845    2.6261    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6194    2.6261    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395    0.4125    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 13 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4678

>  <JC_XSMILES>
CC(=O)NC1=CC=C(C=C1)C2=NC3=C(N2)C4=CC(I)=CC=C4C5=CC=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2956

>  <W2 Pf proliferation inhibition EC50 uM>
0.362

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046875

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-468
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7615   -5.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0964   -5.4349    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3264   -6.8870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9908   -7.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4757   -8.3081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2962   -8.2219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7811   -8.8893    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.6318   -7.4682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1468   -6.8007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4522   -7.3820    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -4.7878   -6.6283    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -4.9372   -8.0494    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 11 10  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
  9 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
  7 30  4  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 31 36  1  0  0  0  0
  5 37  4  0  0  0  0
 37 38  1  0  0  0  0
 37 39  4  0  0  0  0
  2 39  4  0  0  0  0
M  CHG  2  25   1  26  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-468

>  <JC_XSMILES>
CC1=CC=C(NC2=NC(NN=CC3=CC=C(O3)C4=CC=C(Cl)C(=C4)[N+]([O-])=O)=NC(=N2)N5CCOCC5)C(Br)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.065

>  <W2 Pf proliferation inhibition EC50 uM>
1.319

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4680
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
  9 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 16 24  4  0  0  0  0
 14 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 13 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4680

>  <JC_XSMILES>
CCSCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(OC)C(Br)=C3)C(=O)CCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.371

>  <W2 Pf proliferation inhibition EC50 uM>
0.36

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023255814

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4681
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 15 22  4  0  0  0  0
 13 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 12 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4681

>  <JC_XSMILES>
CCCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Cl)C(Cl)=C3)C(=O)CCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.574

>  <W2 Pf proliferation inhibition EC50 uM>
0.359

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022988506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4682
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
    4.3206    2.3003    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4980    2.3620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1400    3.1053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3173    3.1669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8526    2.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2105    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0332    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3912    0.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2162    0.9370    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7305    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5189    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1237   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9401   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1517   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5470   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8037   -0.8703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0604   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8768    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0884    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9049    1.3395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4837   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6673   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4556   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0625   -1.3914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2461   -2.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6413   -2.7569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1471   -2.5137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3306   -1.7094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2741   -1.1483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
  8 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 17 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4682

>  <JC_XSMILES>
FC1=CC=CC=C1C2NC3=CC=CC=C3NC4=C2C(=O)CC(C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.462

>  <W2 Pf proliferation inhibition EC50 uM>
0.359

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011764706

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4683
  Mrv1591402191617072D          

 43 48  0  0  0  0            999 V2000
   12.1144    2.8904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5624    2.2773    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.8173    1.4927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6243    1.3211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8792    0.5365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3272   -0.0766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5202    0.0949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2653    0.8796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4583    1.0511    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.9063    0.4380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0993    0.6095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8444    1.3941    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.3964    2.0072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2034    1.8357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0374    1.5657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7825    2.3503    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4854    0.9526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6784    1.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -1.5105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195   -1.9230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195   -2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050   -3.1605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095   -2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239   -3.1605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095   -1.9230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050   -1.5105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896    1.6387    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 26 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 35 36  4  0  0  0  0
 30 36  4  0  0  0  0
 28 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  1  0  0  0  0
 40 42  4  0  0  0  0
 42 43  4  0  0  0  0
 25 43  4  0  0  0  0
 37 43  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4683

>  <JC_XSMILES>
COC1=CC=CC=C1N2CCN(CC2)C(=O)CCCCSC3=NN=C4C(=N3)N(CC5=CC=C(F)C=C5)C6=CC=C(F)C=C46

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2653

>  <W2 Pf proliferation inhibition EC50 uM>
0.2067

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>57.73

>  <Powder data?>
Yes

>  <IFI value>
0.009090909

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4686
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -6.2599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -7.0445    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -7.0445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -7.7120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8671   -8.4657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6876   -8.5519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3822   -9.1331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7177   -9.8868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2328  -10.5542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5877  -10.4680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9232   -9.7143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4383   -9.0469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0726  -11.1354    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7401  -10.6505    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4052  -11.6203    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5575  -11.8029    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2220  -12.5565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7069  -13.2240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5274  -13.1377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8629  -12.3841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3780  -11.7166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -6.2599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
  8 27  4  0  0  0  0
  5 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4686

>  <JC_XSMILES>
CC(C)(C)C1=CSC(NC(=O)C2=CC=C(C=C2)S(=O)(=O)N3CCCCC3)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.1753

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
49.1

>  <Powder data?>
Yes

>  <IFI value>
0.033707865

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4689
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 16 15  1  4  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 20 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4689

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1OC)C(=O)ON=C(N)CC2=CC=CC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2796

>  <W2 Pf proliferation inhibition EC50 uM>
0.1711

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.06

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-469
  Mrv1591402191617072D          

 43 46  0  0  0  0            999 V2000
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  2  0  0  0  0
 18 33  4  0  0  0  0
 33 34  4  0  0  0  0
 15 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  2  0  0  0  0
 35 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 41 43  1  0  0  0  0
M  CHG  2  30   1  31  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-469

>  <JC_XSMILES>
COC1=CC=CC=C1N2CCN(CC2)C3=CC=C(NC(=O)\C=C\C4=CC=C(C=C4)[N+]([O-])=O)C=C3C(=O)NCCCN(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2904

>  <W2 Pf proliferation inhibition EC50 uM>
0.1214

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.921

>  <Powder data?>
No

>  <IFI value>
0.101010101

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4692
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -3.6791   10.1277    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501   10.1277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    8.8902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    8.8902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    8.4777    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2337    7.7632    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4087    9.1922    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    8.0652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    7.2402    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.0027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186    4.2803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637    3.4956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387    3.4956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837    4.2803    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4692

>  <JC_XSMILES>
ClC1=CC=C(C=C1)S(=O)(=O)N2CCC(CC2)C(=O)NCC3=CC=CO3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.514

>  <W2 Pf proliferation inhibition EC50 uM>
0.355

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.008849558

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4698
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
 10 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
  9 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
  8 29  1  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4698

>  <JC_XSMILES>
CC1CCN(CC1)C2=C(N(C(C)=O)C3=CC=CC(F)=C3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2412

>  <W2 Pf proliferation inhibition EC50 uM>
0.2333

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
66.41

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-470
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    1.8500    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4539    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1039    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7179    2.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769    2.4777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-470

>  <JC_XSMILES>
CC1CCCN(C1)S(=O)(=O)C2=CC(Br)=CC3=C2N(CC3)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.73

>  <W2 Pf proliferation inhibition EC50 uM>
1.318

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4701
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    1.0856   -4.4667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4725   -3.9146    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3121   -4.1696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4836   -4.9765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2683   -5.2315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8814   -4.6794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7098   -3.8725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9252   -3.6175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -2.8106    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -2.1975    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -1.4830    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -1.6545    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 21 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
M  CHG  2  26   1  27  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4701

>  <JC_XSMILES>
COC1=CC=CC=C1N2N=NN=C2SCC(=O)NC3=CC(=CC=C3C)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.651

>  <W2 Pf proliferation inhibition EC50 uM>
0.349

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027522936

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4705
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    1.0663   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227    1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489    0.8152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    1.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483    2.5100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175    3.0199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 14 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
 30 31  4  0  0  0  0
 13 31  4  0  0  0  0
  3 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4705

>  <JC_XSMILES>
CCC(C(=O)OC1=CC=CC=C1C2=C(NC(C)(C)CC(C)(C)C)N3C=CC(C)=CC3=N2)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.894

>  <W2 Pf proliferation inhibition EC50 uM>
0.0347

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4706
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4888   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5986   -3.9898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7479   -5.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9275   -5.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5919   -6.2508    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7714   -6.3370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4359   -7.0907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4425   -4.8297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7781   -4.0760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 14 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
  9 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
  6 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  22
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4706

>  <JC_XSMILES>
CCOC(=O)C1=C(C)C(CC2=CC=C(OCC)C=C2)=C(C)N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2787

>  <W2 Pf proliferation inhibition EC50 uM>
0.347

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015151515

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4708
  Mrv1591402191617072D          

 38 43  0  0  0  0            999 V2000
    7.5345   -0.6513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7499   -0.9062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368   -0.3542    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3522   -0.6091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1807   -1.4161    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7391   -0.0571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8253    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5398    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0717    1.0990    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9001    1.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5132    2.4580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3417    3.2649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9548    3.8170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7394    3.5620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9110    2.7550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2979    2.2030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5196    0.4859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9321   -0.2286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5196   -0.9431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6946   -0.9431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2821   -1.6576    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2821   -0.2286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6946    0.4859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1426    1.0990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3889    0.7634    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4752   -0.0571    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8621   -0.6091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0336   -1.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4205   -1.9681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3641   -1.7132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5356   -0.9062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0775   -0.3542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3141    1.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7010    2.4580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8726    3.2649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6572    3.5199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2703    2.9678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0988    2.1609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
  6 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 22 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 24 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4708

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N(CC2=CC=CC=C2)C3=C1C=C(O)C4=C3C(=NN4C5=CC=CC=C5)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
1.061

>  <W2 Pf proliferation inhibition EC50 uM>
0.345

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-471
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -1.4604    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2784   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5159    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    0.7310    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7534    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5159    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 12 22  1  0  0  0  0
  8 22  1  0  0  0  0
  6 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-471

>  <JC_XSMILES>
COC(=O)C1=C(SC2=C1CCN(CC(C)C3=CC=CC=C3)C2)S(=O)(=O)NCCN(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.606

>  <W2 Pf proliferation inhibition EC50 uM>
>1.318

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.029126214

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4711
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
   -0.2228   -1.9441    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -0.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -0.1923    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3821    0.6120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9868    1.1732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8032    1.9775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4080    2.5386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2244    3.3430    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1964    2.2955    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8011    2.8566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5895    2.6134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7731    1.8091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1683    1.2480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3799    1.4912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7752    0.9300    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -0.3758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8843    0.2692    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7279   -1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -1.8624    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -2.0460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3821   -2.8503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9868   -3.4115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8032   -4.2158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0149   -4.4590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4101   -3.8978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5937   -3.0935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
  8 18  4  0  0  0  0
  6 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 23 30  1  0  0  0  0
  5 30  4  0  0  0  0
 30 31  4  0  0  0  0
  2 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4711

>  <JC_XSMILES>
ClC1=CC=C2N(CC3=CC(=O)N4C=CC=CC4=N3)C(=O)CN=C(C5=CC=CC=C5)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
3.55

>  <W2 Pf proliferation inhibition EC50 uM>
0.344

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4713
  Mrv1591402191617072D          

 44 51  0  0  0  0            999 V2000
    3.8903    2.0532    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028    1.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278    1.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5403    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8903    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0653    0.6243    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804   -0.0431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353   -0.8278    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804    1.2917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353    2.0764    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    3.9243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2875    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1125    0.6243    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -2.6757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 13 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 11 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 24 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 31 38  2  0  0  0  0
 15 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 39 44  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4713

>  <JC_XSMILES>
FC1=CC=CC=C1N2C(=O)C3C(C2=O)C5(C4=CC=CC=C4)C(=O)C3(C6=CC=CC=C6)C(C7=CC=CC=C7)=C5C8=CC=CC=C8

>  <PF proliferation inhibition 3D7 EC50 uM>
0.811

>  <W2 Pf proliferation inhibition EC50 uM>
0.344

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4714
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -0.3327   -6.5651    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.4189   -5.7447    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.2485   -5.2597    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1726   -5.4091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8400   -5.8940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5937   -5.5585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6799   -4.7380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0125   -4.2531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2588   -4.5886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -3.4326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -3.0201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6417   -2.2131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4856   -2.8806    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 15 13  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 18 26  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  STY  1   1 DAT
M  SAL   1  1  26
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4714

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(=C1)C2=CC=C(O2)C=NNC3=NC4=CC=CC=C4N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.379

>  <W2 Pf proliferation inhibition EC50 uM>
0.344

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4715
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -0.9429   -5.4600    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400   -4.0623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  1  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4715

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C(=O)CC2OC(=O)C3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.717

>  <W2 Pf proliferation inhibition EC50 uM>
0.342

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.053333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4716
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1759    4.3338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9605    4.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9605    3.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1759    2.9989    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 29 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4716

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4=CC=CO4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.828

>  <W2 Pf proliferation inhibition EC50 uM>
0.0341

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4719
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
  6 28  4  0  0  0  0
 17 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4719

>  <JC_XSMILES>
CCOC(=O)C1=C(CSC2=CC=CC=C2)OC3=CC(CN(C)C)=C(O)C(Cl)=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.321

>  <W2 Pf proliferation inhibition EC50 uM>
0.2095

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
61.57

>  <Powder data?>
Yes

>  <IFI value>
0.046153846

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4720
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175   -4.4158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483   -3.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878   -3.3762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489   -2.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227   -3.3151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    4.3034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    5.0178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    5.0178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    4.3034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 13 18  4  0  0  0  0
 11 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  2  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4720

>  <JC_XSMILES>
CC(C)(C)CC(C)(C)NC1=C(N=C2C=CC=CN12)C3=CC=CC=C3OC(=O)\C=C\C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.457

>  <W2 Pf proliferation inhibition EC50 uM>
0.034

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4722
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  6  5  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  8 18  4  0  0  0  0
 13 18  4  0  0  0  0
  4 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4722

>  <JC_XSMILES>
CC1=NC(NN=CC2=C(O)C=CC3=CC=CC=C23)=CC(=N1)N4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.609

>  <W2 Pf proliferation inhibition EC50 uM>
0.339

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4723
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -0.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -0.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    5.6479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  4  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 12 24  4  0  0  0  0
 24 25  2  0  0  0  0
 24 26  4  0  0  0  0
 10 26  4  0  0  0  0
 26 27  1  0  0  0  0
  6 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 34 35  4  0  0  0  0
 28 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4723

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N=c2sc(=CC3=CC=CC=C3OC(C)=O)c(=O)n2C1C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.515

>  <W2 Pf proliferation inhibition EC50 uM>
0.339

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.070588235

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4724
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  4  0  0  0  0
  4 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 25 26  4  0  0  0  0
 19 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4724

>  <JC_XSMILES>
CCCC1=C(C(=O)OCC)C2=CC(O)=CC=C2N1C3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1328

>  <W2 Pf proliferation inhibition EC50 uM>
0.339

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4725
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
   -0.3657    5.7135    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0957    4.9339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.7780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9845    3.9984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4444    3.3748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.5952    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5246    2.4393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0647    3.0630    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7946    1.6598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6048    1.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1449    2.1275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9550    1.9716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2251    1.1921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0352    1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3052    0.2566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7651   -0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9550   -0.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6850    0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8748    0.7243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3347    0.1007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5246    0.2566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9845   -0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1744   -0.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0957    0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4444    1.1921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2546    1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3657    3.5307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6358    4.3103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 10 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  9 26  4  0  0  0  0
 21 26  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4725

>  <JC_XSMILES>
ClC1=CC=C(NC(=O)C2=C3CCC4=CC=CC=C4C3=NC5=CC=CC=C25)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.41

>  <W2 Pf proliferation inhibition EC50 uM>
0.338

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4726
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  3 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 10 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  1  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4726

>  <JC_XSMILES>
O=C1C(NC2CCCC2)=C(N3CCCCC3)C(=O)C4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02238

>  <W2 Pf proliferation inhibition EC50 uM>
0.0342

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.14

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4728
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   10.0618   -0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2368   -0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8243   -1.3184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2368   -2.0329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8243   -2.7474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2368   -3.4618    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8243   -4.1763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9993   -2.7474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5868   -3.4618    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    7.5868   -2.0329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9993   -1.3184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7618   -2.0329    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3493   -2.7474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7618   -3.4618    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5243   -2.7474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1118   -3.4618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.4618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -2.7474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.0329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1118   -2.0329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5243   -1.3184    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3493   -1.3184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7618   -0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5868   -0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3493    0.1105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5243    0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1118    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743    0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7618    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3493    1.5395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9993    0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8243    0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2368    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8243    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9993    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5868    2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
  3 11  4  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 25 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
 38 39  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4728

>  <JC_XSMILES>
COC1=CC(OC)=C(Br)C(=C1)N2C(=O)C3=CC=CC=C3N=C2C(C)N(CCC(C)C)C(=O)C4=CC=CC=C4C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
<0.0337

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028037383

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4730
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
  6 11  4  0  0  0  0
  3 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 12 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4730

>  <JC_XSMILES>
OC1=C(C=CC2=CC=CN=C12)C(NC(=O)CC3=CC=CC=C3)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.209

>  <W2 Pf proliferation inhibition EC50 uM>
0.337

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.09375

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4732
  Mrv1591402191617072D          

 19 19  0  0  0  0            999 V2000
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 14 15  2  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4732

>  <JC_XSMILES>
CCCN(CCC)C1=CC(=O)C(=CC1=O)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2159

>  <W2 Pf proliferation inhibition EC50 uM>
0.1707

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
50.9

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4733
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  3 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4733

>  <JC_XSMILES>
COC1=CC(CNC2=CC=C(C=C2)N3CCCCC3)=CC=C1OCC4=CC=CC=C4F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.475

>  <W2 Pf proliferation inhibition EC50 uM>
0.335

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4736
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
  9 33  1  0  0  0  0
 33 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4736

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2C(C(=O)NC3=CC(Cl)=C(OC)C=C3OC)C4=CC=CC=C4C(=O)N2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.378

>  <W2 Pf proliferation inhibition EC50 uM>
0.333

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4737
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
  6 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 16 27  1  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4737

>  <JC_XSMILES>
CCOC(=O)C(CC1=CC=C(O)C=C1)NC2=CC(=O)C(=O)C3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3046

>  <W2 Pf proliferation inhibition EC50 uM>
0.333

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4738
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -0.6895   -0.9185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1175   -0.7470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6695   -1.3601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4765   -1.1885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7314   -0.4039    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1794    0.2092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4343    0.9938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9494    1.6613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4343    2.3287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2190    2.0738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2190    1.2488    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0285   -1.8016    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8535   -1.8016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4056   -1.1885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2125   -1.3601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4675   -2.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9154   -2.7578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1085   -2.5862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4410   -3.0712    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7736   -2.5862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9666   -2.7578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7117   -3.5424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4567   -4.3270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4146   -2.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3924   -2.3162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  7 11  4  0  0  0  0
  4 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  3  0  0  0  0
 21 24  4  0  0  0  0
  3 24  4  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4738

>  <JC_XSMILES>
CCC1=C(NCC2=CC=CO2)N3C4=CC=CC=C4N=C3C(C#N)=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2707

>  <W2 Pf proliferation inhibition EC50 uM>
0.333

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03649635

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4740
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -1.3222    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    2.0009    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    1.1759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0597   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1953   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2897   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1101   -3.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4457   -2.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2662   -2.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7511   -2.9774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4155   -3.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9005   -4.3985    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7209   -4.3123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5951   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2595   -4.5710    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4390   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0203   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5052   -3.2361    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2752   -1.7840    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  4  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 15 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 13 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 11 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4740

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2=CC(=CC3=CC=CC(OC)=C3OC)C(=O)O2

>  <PF proliferation inhibition 3D7 EC50 uM>
4.76

>  <W2 Pf proliferation inhibition EC50 uM>
0.332

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4743
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -3.8837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -4.2703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489    0.8152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227    1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    1.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175    3.0199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483    2.5100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 19 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  4  0  0  0  0
 18 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4743

>  <JC_XSMILES>
COC1=CC=CC(=C1)C(=O)OC2=CC=CC=C2C3=C(NC(C)(C)CC(C)(C)C)N4C=CC=CC4=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.27

>  <W2 Pf proliferation inhibition EC50 uM>
0.033

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4744
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.7623   -1.5236    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0478   -1.1111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6667   -1.5236    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6667   -2.3486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0008   -2.8335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2542   -3.6181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0792   -3.6181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3341   -2.8335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0478   -0.2861    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6955    0.0719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8791    0.8762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3647    1.5212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4603    1.5212    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9747    0.8762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7911    0.0719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8183    2.2645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3535    2.9461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7115    3.6894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5342    3.7511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9989    3.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6410    2.3261    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8921    4.4944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2501    5.2377    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  2  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
  9 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4744

>  <JC_XSMILES>
S=C(NC1CCCC1)N2CCCN(CC2)C3=CC=C(C=N3)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.65

>  <W2 Pf proliferation inhibition EC50 uM>
0.33

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.007874016

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4745
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2942    0.4014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0788    0.6563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2504    1.4633    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.6919    0.1043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5204   -0.7027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4559   -4.0144    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
 13 14  1  0  0  0  0
  3 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  2 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4745

>  <JC_XSMILES>
CC1=C(C(=O)NC2=CC(Cl)=CC=C2Cl)C(=NO1)C3=CC=CC=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.369

>  <W2 Pf proliferation inhibition EC50 uM>
0.33

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011494253

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4747
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    1.0663   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227    1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489    0.8152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    1.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483    2.5100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175    3.0199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 14 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 13 30  4  0  0  0  0
  3 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4747

>  <JC_XSMILES>
CCC(C(=O)OC1=CC=CC=C1C2=C(NC(C)(C)CC(C)(C)C)N3C=CC=CC3=N2)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.685

>  <W2 Pf proliferation inhibition EC50 uM>
0.0329

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.047169811

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4750
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    2.1435    1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4291    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3790    0.3412    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1433   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7143    1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -2.4749    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -4.1249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4291   -4.9499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -4.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 10 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  8 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4750

>  <JC_XSMILES>
CCOC(=O)C1=CN(C=C(C1C2=CC=CC=C2OCC)C(=O)OCC)C3=CC(C)=CC=C3C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2639

>  <W2 Pf proliferation inhibition EC50 uM>
0.328

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4751
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -5.0605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -6.4895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 21 27  1  0  0  0  0
 27 28  1  0  0  0  0
  6 29  4  0  0  0  0
 29 30  4  0  0  0  0
  3 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4751

>  <JC_XSMILES>
CCC1=CC=C(NC(=O)C2=CC=C(F)C(=C2)S(=O)(=O)NC3CCCC(C)C3C)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.353

>  <W2 Pf proliferation inhibition EC50 uM>
0.2156

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
65.96

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4753
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.1190   -4.5039    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2822   -1.8800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 11 21  1  0  0  0  0
 16 21  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4753

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC=C1CN2C(=O)C(=O)C3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.71

>  <W2 Pf proliferation inhibition EC50 uM>
0.326

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4754
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
    2.1434    5.3625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184    4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684    4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -1.4924    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8419   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -0.1576    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007   -0.4170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6077   -0.2455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0202   -0.9600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4681   -1.5731    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  4  0  0  0  0
 25 26  4  0  0  0  0
 18 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  2  0  0  0  0
 27 29  4  0  0  0  0
 16 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 31 35  4  0  0  0  0
 10 36  4  0  0  0  0
  5 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4754

>  <JC_XSMILES>
FC(F)(F)C1=CC=C(Cl)C(NC(=O)CSC2=NC3=CC4=C(OCO4)C=C3C(=O)N2CC5=CC=CO5)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2469

>  <W2 Pf proliferation inhibition EC50 uM>
0.326

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.043478261

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4758
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    8.6203   -1.3503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8933   -1.7403    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1920   -1.3057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4650   -1.6956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7638   -1.2610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0368   -1.6510    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0110   -2.4756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7896   -0.4364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5166   -0.0464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2178   -0.4811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9448   -0.0911    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0883   -0.0018    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1141    0.8228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3613   -0.3918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3355   -1.2164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6601    0.0428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5995    0.8656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7983    1.0622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3637    0.3610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8963   -0.2691    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391    0.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1045   -0.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2799   -0.2887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1101    0.4383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3245    1.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1491    1.1137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5837    1.8150    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8176    2.1212    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7523    2.6226    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4083    1.7892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
  8 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  2  0  0  0  0
 27 30  1  0  0  0  0
 18 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4758

>  <JC_XSMILES>
COC1=CC(OC)=C(C=C1Cl)N(C)C(=O)C2=CC3=C(S2)C4=CC=CC=C4S(=O)(=O)C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.113

>  <W2 Pf proliferation inhibition EC50 uM>
0.1793

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>55.65

>  <Powder data?>
Yes

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4760
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
  7 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 17 26  4  0  0  0  0
 26 27  1  0  0  0  0
M  CHG  2  14   1  15  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4760

>  <JC_XSMILES>
CCCC(=O)NC(C1=CC=CC(=C1)[N+]([O-])=O)C2=CC=C3C=CC=NC3=C2O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.32

>  <W2 Pf proliferation inhibition EC50 uM>
0.1249

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
38.81

>  <Powder data?>
Yes

>  <IFI value>
0.119402985

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4761
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    3.2227    3.6495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6707    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9256    2.2518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498   -4.0609    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  7 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
  5 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  CHG  1   7   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4761

>  <JC_XSMILES>
CC1=CC=C(C[N+]2=C3CCCN3C(=C2)C4=CC=C(F)C=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.867

>  <W2 Pf proliferation inhibition EC50 uM>
0.321

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4762
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -1.3222    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    2.0009    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2752   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0203   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1953   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2897   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1101   -3.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4457   -2.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2662   -2.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7511   -2.9774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4155   -3.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5951   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2595   -4.5710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5716   -2.8911    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.9071   -2.1375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.0565   -3.5586    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0597   -1.7840    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8443   -1.5291    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.5052   -3.2361    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.1696   -3.9898    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.3257   -3.1499    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 12 24  4  0  0  0  0
  9 24  4  0  0  0  0
 24 25  1  0  0  0  0
 11 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
M  CHG  6  21   1  22  -1  24   1  25  -1  26   1  27  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4762

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2N=C(C(NC3=CC=C(C=C3C)[N+]([O-])=O)=[N+]2[O-])[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.297

>  <W2 Pf proliferation inhibition EC50 uM>
0.32

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4764
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -4.9455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -5.1170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -4.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1262   -4.3163    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6111   -4.9837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4316   -4.8975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9836   -5.5106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7373   -5.1750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6511   -4.3546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8441   -4.1830    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -3.7894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9252   -2.9825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7098   -2.7275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3229   -3.2796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1075   -3.0246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2791   -2.2177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6660   -1.6656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8814   -1.9206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
  8 16  4  0  0  0  0
  5 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  2 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 24 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4764

>  <JC_XSMILES>
O=C(NCC1=NN=C(SCC2CCCO2)N1CC3=CC=CC=C3)C4=CC=CC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
1.866

>  <W2 Pf proliferation inhibition EC50 uM>
<0.02648

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.28

>  <Powder data?>
No

>  <IFI value>
0.017241379

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4765
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  6 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 16 22  1  0  0  0  0
 11 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4765

>  <JC_XSMILES>
CCOC(=O)C1=C(CC)N=C(N=C1C(=O)N2CCC(C)CC2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01296

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.06

>  <Powder data?>
No

>  <IFI value>
0.02247191

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4766
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    3.6664    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    5.8098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    5.8098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    6.5242    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  4 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  2 17  4  0  0  0  0
 14 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4766

>  <JC_XSMILES>
CC1=NC(N2CCCCC2)=C3C(C)=C(SC3=N1)C(=O)N4CCN(CC4)C5=CC=CC(Cl)=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.319

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4767
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  2  0  0  0  0
M  CHG  2  29   1  30  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4767

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2CC(=O)C3=C(C2)NC(=O)CC3C4=CC=C(C=C4)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2618

>  <W2 Pf proliferation inhibition EC50 uM>
0.2292

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
72.2

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4769
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8936    1.5700    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6782    1.8249    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6782    2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3457    3.1348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8936    2.9049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
  3 12  4  0  0  0  0
 12 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4769

>  <JC_XSMILES>
COC1=CC=C2C(Cl)=C(SC2=C1Cl)C(=O)NC3=NOC(C)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.43

>  <W2 Pf proliferation inhibition EC50 uM>
0.3161

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4770
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4770

>  <JC_XSMILES>
FC1=CC=CC=C1NNC(=O)C2=C(F)C=CC=C2Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
<0.0316

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4772
  Mrv1591402191617072D          

 24 28  0  0  0  0            999 V2000
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6116    2.1394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1636    2.7525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7511    3.4670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0060    4.2516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4540    4.8647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6470    4.6932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3921    3.9086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9441    3.2955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  3 11  1  0  0  0  0
  6 11  4  0  0  0  0
  2 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 12 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4772

>  <JC_XSMILES>
O=C(N1CCC2=CC=CC=C12)C3=C4CCCC4=NC5=CC=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
1.942

>  <W2 Pf proliferation inhibition EC50 uM>
<0.0367

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.67

>  <Powder data?>
No

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4774
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0992    1.0091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0992    1.8341    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.0890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.8736    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9457    3.0451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2006    3.8298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0076    4.0013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5596    3.3882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3047    2.6036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4977    2.4321    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3687    1.4216    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
  2 10  4  0  0  0  0
  3 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 14 22  4  0  0  0  0
 11 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4774

>  <JC_XSMILES>
CC1=C(N2C=CC=NC2=N1)C3=CSC(NC4=CC=CC=N4)=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1886

>  <W2 Pf proliferation inhibition EC50 uM>
0.3137

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4775
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
   -1.1962   -6.4292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4817   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2328   -6.4292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9473   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6617   -6.4292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3762   -6.0167    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0907   -6.4292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8443   -6.0937    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.0159   -5.2867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3964   -6.7067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9839   -7.4212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1769   -7.2497    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.2169   -6.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5524   -5.8668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3729   -5.7806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8578   -6.4480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6783   -6.3618    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5223   -7.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0072   -7.8692    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7018   -7.2880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 13 20  4  0  0  0  0
M  CHG  1   8   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4775

>  <JC_XSMILES>
CCCCCSC1=[N+](C)C(=CS1)C2=CC=C(O)C(O)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2536

>  <W2 Pf proliferation inhibition EC50 uM>
0.3131

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.06504065

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4776
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  4  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  1  6  4  0  0  0  0
  4  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4776

>  <JC_XSMILES>
C1=CC=C(N=C1)C2=CC=CC(=N2)C3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1545

>  <W2 Pf proliferation inhibition EC50 uM>
0.0392

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.56

>  <Powder data?>
Yes

>  <IFI value>
0.216216216

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-478
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    5.7158   -1.6500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-478

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(Cl)=C1N2CCN(CC2)S(=O)(=O)CC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.165

>  <W2 Pf proliferation inhibition EC50 uM>
1.305

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4780
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -5.5337   -5.6992    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 17 25  4  0  0  0  0
  5 26  4  0  0  0  0
 26 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4780

>  <JC_XSMILES>
ClC1=CC=C(OCC(=O)NC2=CC=CC(=C2)C3=NC4=NC=CC=C4O3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.638

>  <W2 Pf proliferation inhibition EC50 uM>
0.3108

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4781
  Mrv1591402191617072D          

 35 40  0  0  0  0            999 V2000
    7.9564    5.4761    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3244    6.0064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5492    6.2886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4059    7.1010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0379    7.6313    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8132    7.3492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9564    6.5367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8947    8.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5266    8.9741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3834    9.7866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0154   10.3169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7906   10.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9339    9.2222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3019    8.6919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9119    5.2919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3244    4.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9119    3.8630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0869    3.8630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5349    3.2499    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8675    4.4059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6744    4.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0869    5.2919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
  2 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
 20 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 30 34  4  0  0  0  0
 34 35  4  0  0  0  0
 27 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4781

>  <JC_XSMILES>
OC1(CCN(CC1)CC2CCCCC2)C3=CC=C4OC(=CC4=C3)C(=O)NC5=CC=C6OCOC6=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.442

>  <W2 Pf proliferation inhibition EC50 uM>
0.3108

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.042372881

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4782
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1839   -5.0269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7359   -5.6400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3234   -6.3545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5165   -6.1830    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -2.8106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -2.1975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -1.4830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -1.6545    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  4  0  0  0  0
  7 20  4  0  0  0  0
  2 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4782

>  <JC_XSMILES>
O=C(NC(=S)NC1=CC=C(NC(=O)C2=CC=CS2)C=C1)C3=CC=CO3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.468

>  <W2 Pf proliferation inhibition EC50 uM>
0.3106

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4783
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6817   -0.4647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4700   -0.2216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7714    0.5464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3589    1.2609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5431    1.3838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0617    0.8227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  4 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 13 19  1  0  0  0  0
 12 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 11 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4783

>  <JC_XSMILES>
CC(=O)N(C1CCCCC1)C2=C(N3CCCCCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1368

>  <W2 Pf proliferation inhibition EC50 uM>
0.0939

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
30.24

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4784
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -1.3144    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 12 23  1  0  0  0  0
 18 23  4  0  0  0  0
 13 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 24 28  4  0  0  0  0
  8 29  4  0  0  0  0
 29 30  4  0  0  0  0
  3 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4784

>  <JC_XSMILES>
COC1=CC(OC)=C(NC(=O)C2C(N(C)C(=O)C3=CC=CC=C23)C4=CC=CS4)C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.32

>  <W2 Pf proliferation inhibition EC50 uM>
0.3105

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027027027

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4786
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -2.1730    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -3.6020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
  4 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   5
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4786

>  <JC_XSMILES>
OC1=NC(=NC(=C1Br)C(F)(F)F)C2=CC=CC=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.49

>  <W2 Pf proliferation inhibition EC50 uM>
<0.02563

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.27

>  <Powder data?>
No

>  <IFI value>
0.087719298

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-479
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7146   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7146   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4291    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8580   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5725   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869   -1.6501    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1099   -0.3836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9344   -0.3548    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0811    0.4409    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1387   -1.2081    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.2774    0.2872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1597    0.9868    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.9771    0.7243    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4222   -0.1500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
 17 18  1  0  0  0  0
  8 18  1  0  0  0  0
 12 18  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 10 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-479

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=NC(N=C3C=CC(Cl)=CN23)(C(F)(F)F)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.21

>  <W2 Pf proliferation inhibition EC50 uM>
>1.304

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4793
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    4.7079    7.8375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    7.0125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    4.5375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8829    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5329    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7179    2.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4630    2.8207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0150    3.4338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8220    3.2623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769    2.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4793

>  <JC_XSMILES>
ClC1=CC=C(C=C1Cl)S(=O)(=O)NCCNC2=NC=NC3=C2C(=CS3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2902

>  <W2 Pf proliferation inhibition EC50 uM>
0.3072

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.016666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4794
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4794

>  <JC_XSMILES>
CC(C)OC(=O)C1=C(C)NC2=C(C1C3=CC=C(F)C=C3)C(=O)CC(C2)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.358

>  <W2 Pf proliferation inhibition EC50 uM>
0.0913

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
29.73

>  <Powder data?>
Yes

>  <IFI value>
0.070588235

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-480
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 14 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 25 35  4  0  0  0  0
 11 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-480

>  <JC_XSMILES>
COC1=CC=CC=C1CNC2=NC=C(C(=O)NCC3=CC=CC=C3)C(NCCC4=CC=CC=C4)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.284

>  <W2 Pf proliferation inhibition EC50 uM>
>1.299

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019230769

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4802
  Mrv1591402191617072D          

 20 20  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164    0.1105    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414    1.5395    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.7145    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    0.7145    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  2  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
  4 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4802

>  <JC_XSMILES>
CC1CN(C(C)CN1C(=O)C(Cl)(Cl)Cl)C(=O)C(Cl)(Cl)Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
2.054

>  <W2 Pf proliferation inhibition EC50 uM>
0.3022

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4804
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -1.4398   -0.5616    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.2683   -1.3685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4836   -1.6235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3121   -2.4304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9252   -2.9825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7098   -2.7275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8814   -1.9206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -3.7894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -4.9455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -5.1170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -4.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1262   -4.3163    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 14 23  4  0  0  0  0
 18 23  4  0  0  0  0
  9 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  8 26  4  0  0  0  0
 26 27  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  25
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4804

>  <JC_XSMILES>
BrC1=CC=C(C=C1)n2c(CNC(=O)C3=CC=CC4=CC=CC=C34)n[nH]c2=S

>  <PF proliferation inhibition 3D7 EC50 uM>
0.293

>  <W2 Pf proliferation inhibition EC50 uM>
0.3012

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022222222

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4806
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
  8 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4806

>  <JC_XSMILES>
CC1=CC(C)=C2CN(COC2=C1)CC3=CC=CC=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1918

>  <W2 Pf proliferation inhibition EC50 uM>
0.3003

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.033333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4808
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.5050    5.6355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3200    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3300    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 10 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4808

>  <JC_XSMILES>
CC(C)(C)NCC(O)CN1C2=CC=C(Cl)C=C2C3=CC(Cl)=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2578

>  <W2 Pf proliferation inhibition EC50 uM>
0.0563

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.78

>  <Powder data?>
Yes

>  <IFI value>
0.024

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4809
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -0.8250   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.2211    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -0.2211    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    1.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0799    1.9925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8646    2.2474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    2.4774    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2549    1.9925    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    0.4934    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    3.3024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    3.7149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    4.5399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    4.9524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    5.7774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    4.5399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.7149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.2211    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8875   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7125   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1250   -3.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7125   -3.7934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1250   -4.5079    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9500   -4.5079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8875   -3.7934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750   -4.5079    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -4.5079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750   -3.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
  4 14  4  0  0  0  0
 14 15  2  0  0  0  0
 11 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
  3 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 27 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4809

>  <JC_XSMILES>
CCC(N1N=C(C)C2=C(C)N(N=C2C1=O)C3=CC=C(C)C=C3)C(=O)NCC4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2732

>  <W2 Pf proliferation inhibition EC50 uM>
0.2993

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4812
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    0.2498   -4.0609    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076    1.3686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473    2.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8543    2.3248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1092    3.1094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5572    3.7225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498    3.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  8 23  4  0  0  0  0
 19 23  4  0  0  0  0
M  CHG  1  10   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4812

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C2=C[N+](CCC3=CC=CC=C3)=C4CCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.38

>  <W2 Pf proliferation inhibition EC50 uM>
0.2988

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.05

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4815
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4815

>  <JC_XSMILES>
OC1=CC2=CC=CC=C2C=C1C(=O)NC3=CC=CC=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.327

>  <W2 Pf proliferation inhibition EC50 uM>
0.2981

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.123076923

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4816
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  4  0  0  0  0
  7 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4816

>  <JC_XSMILES>
CCCCCCC1=CC(O)=C2C3=C(CCC(C)C3)C(=O)OC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.364

>  <W2 Pf proliferation inhibition EC50 uM>
0.2967

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.072463768

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4818
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -0.7238    5.7312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3882    4.9775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4188    4.8060    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2487    3.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4202    2.8430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007    4.2631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  9 23  4  0  0  0  0
 17 23  4  0  0  0  0
  4 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4818

>  <JC_XSMILES>
CC1=NN(CC(O)CN2C3=CC=C(I)C=C3C4=CC(I)=CC=C24)C(C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.193

>  <W2 Pf proliferation inhibition EC50 uM>
0.2962

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.007246377

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4821
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3058    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8933    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0863    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
  5 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 13 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 12 27  1  0  0  0  0
 27 28  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4821

>  <JC_XSMILES>
CC(=O)N(C1=CC=C(F)C=C1)C2=C(N3CCCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.646

>  <W2 Pf proliferation inhibition EC50 uM>
0.0759

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
25.75

>  <Powder data?>
Yes

>  <IFI value>
0.081081081

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4822
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  1  0  0  0  0
  8 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 20 26  4  0  0  0  0
 26 27  1  0  0  0  0
  6 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4822

>  <JC_XSMILES>
CC1=CC=NC(NC(C2=CC=C3C=CC=NC3=C2O)C4=CC=CC(Cl)=C4Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1522

>  <W2 Pf proliferation inhibition EC50 uM>
0.1441

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>48.96

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4824
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -2.1730   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -3.4914    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -0.6336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    0.0809    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -0.6336    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
  8 19  4  0  0  0  0
 19 20  4  0  0  0  0
  4 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4824

>  <JC_XSMILES>
CCCC1=CC(O)=C2C3=C(CN(C)CC3)C(=O)OC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.554

>  <W2 Pf proliferation inhibition EC50 uM>
0.2939

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4826
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -8.2500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -8.2500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  2  0  0  0  0
 27 29  4  0  0  0  0
 19 29  4  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4826

>  <JC_XSMILES>
CCCCC(CC)C(=O)N1CCN(CC1)C(CC)C2=NC3=CC=CC=C3C(=O)N2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.374

>  <W2 Pf proliferation inhibition EC50 uM>
0.2938

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4827
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
  8 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 24 32  4  0  0  0  0
  6 32  4  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4827

>  <JC_XSMILES>
CCN(CC)C1=NC(NN=CC2=CC=CC(=C2OC)[N+]([O-])=O)=NC(NC3=CC=CC=C3)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2442

>  <W2 Pf proliferation inhibition EC50 uM>
0.2936

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.051948052

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4829
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  5 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 13 21  4  0  0  0  0
 10 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4829

>  <JC_XSMILES>
CN(C)CC1=C(O)C=CC2=C1C=C(CC3=CC=CC=C3)O2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2186

>  <W2 Pf proliferation inhibition EC50 uM>
0.059

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.12

>  <Powder data?>
Yes

>  <IFI value>
0.00729927

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-483
  Mrv1591402191617072D          

 45 49  0  0  0  0            999 V2000
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6085    2.5612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 17 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
  3 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  2  0  0  0  0
 36 38  4  0  0  0  0
 28 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  1  0  0  0  0
 43 45  4  0  0  0  0
 39 45  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-483

>  <JC_XSMILES>
CCC(N(CCC1=CC=CC=C1)C(=O)NC2=C(C=CC=C2C(C)C)C(C)C)C3=NC4=CC=CC=C4C(=O)N3C5=CC=CC(C)=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.071

>  <W2 Pf proliferation inhibition EC50 uM>
1.103

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.51

>  <Powder data?>
No

>  <IFI value>
0.009433962

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4830
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
  6 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  2  0  0  0  0
 20 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  2  0  0  0  0
 24 26  4  0  0  0  0
 18 26  4  0  0  0  0
 26 27  4  0  0  0  0
 14 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4830

>  <JC_XSMILES>
CCOC1=CC(=CC=C1OC(C)C)C2=NN(C)C3=NC(=O)N(C)C(=O)C3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.333

>  <W2 Pf proliferation inhibition EC50 uM>
0.02931

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.307692308

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4831
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    6.2102    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    3.5881    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    3.1465    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    3.9312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    4.1027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    4.8873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    5.5004    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429    6.2850    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7499    6.4565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5569    6.6281    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5784    7.2635    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9214    5.6496    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    5.3289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    4.5442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.9521    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8128   -0.1271    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4628   -0.1271    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 21 27  4  0  0  0  0
 27 28  4  0  0  0  0
 18 28  4  0  0  0  0
 14 29  4  0  0  0  0
 11 29  4  0  0  0  0
 29 30  1  0  0  0  0
  8 30  1  0  0  0  0
 10 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
 31 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4831

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2CC(N3N=CC(C(=O)NC4=CC=C(OC(F)(F)F)C=C4)=C3N2)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2821

>  <W2 Pf proliferation inhibition EC50 uM>
0.293

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4837
  Mrv1591402191617072D          

 30 35  0  0  1  0            999 V2000
    5.6979   -2.4050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2130   -1.7376    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3925   -1.8238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0570   -2.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2365   -2.6637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7516   -1.9963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9311   -2.0825    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4462   -1.4151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7817   -0.6614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6022   -0.5752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0871   -1.2426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9076   -1.1564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2968    0.0060    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.4718    0.0060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2169    0.7907    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4506    1.2756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1956    2.0602    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6294    2.0602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1143    2.7276    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8843    1.2756    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1392    2.0602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9642    2.0602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2192    1.2756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5517    0.7907    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6806    2.7276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5010    2.6414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9860    3.3088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6504    4.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8299    4.1487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3450    3.4813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
  3 12  4  0  0  0  0
 13  9  1  6  0  0  0
 13 14  1  0  0  0  0
 15 14  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 20 18  1  0  0  0  0
 15 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 13 24  1  0  0  0  0
 20 24  1  1  0  0  0
 17 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4837

>  <JC_XSMILES>
COC1=CC=C2OCC(=CC2=C1)[C@@H]3C[C@H]4CN(C(=O)[C@]45CCCN35)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.588

>  <W2 Pf proliferation inhibition EC50 uM>
0.2893

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-484
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -0.2228   -2.7691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2228   -1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -0.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -0.1923    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -0.3758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7279   -1.1191    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -1.8624    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -2.0460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3821   -2.8503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9868   -3.4115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8032   -4.2158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0149   -4.4590    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4101   -3.8978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5937   -3.0935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8843    0.2692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5829    1.0371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0973    1.6821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9131    1.5592    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2145    0.7912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7001    0.1462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 11 18  1  0  0  0  0
  6 18  4  0  0  0  0
 18 19  4  0  0  0  0
  3 19  4  0  0  0  0
  8 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-484

>  <JC_XSMILES>
CCC1=CC=C2N=C(NN=C(C3=CC=NC=C3)C2=C1)C4=CC=NC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.887

>  <W2 Pf proliferation inhibition EC50 uM>
>1.296

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4840
  Mrv1591402191617072D          

 46 51  0  0  0  0            999 V2000
    1.8670    3.5755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3820    2.9081    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5616    2.9943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0766    2.3269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7438    2.4131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0794    3.1668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5945    3.8342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9300    4.5879    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7505    4.6741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2260    3.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7109    4.4154    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3754    5.1691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2288    1.7457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0492    1.8319    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    0.9920    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    0.8205    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1262    0.1913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4617   -0.5624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2822   -0.6486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7671    0.0188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4316    0.7725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6111    0.8587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9165    1.4399    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -4.7370    1.3537    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.5810    2.1936    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
 17 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 30 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  1  0  0  0  0
 39 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 37 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 29 45  4  0  0  0  0
 45 46  2  0  0  0  0
M  CHG  2  26   1  27  -1
M  STY  1   1 DAT
M  SAL   1  1  44
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4840

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1OC)C(=O)N2N=C(CC2C3=CC=CC(=C3)[N+]([O-])=O)C4=C(C5=CC=CC=C5)C6=CC(Br)=CC=C6NC4=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.362

>  <W2 Pf proliferation inhibition EC50 uM>
0.2878

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011111111

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4841
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
   -0.6880   -4.6754    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0300   -5.5585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8505   -5.4723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1860   -6.2260    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5729   -6.7780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8585   -6.3655    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042    0.1028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757    0.9097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612    1.3222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481    0.7702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  1  0  0  0  0
 17 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 16 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   7
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4841

>  <JC_XSMILES>
O=C(\C=C\C1=CNC=N1)N2CCC(CC2)N3C(CC4CCCC4)=NC5=CC=CN=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.671

>  <W2 Pf proliferation inhibition EC50 uM>
0.02874

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009708738

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4842
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6839    0.7846    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6675    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4521    1.0550    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0652    1.6070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    2.0945    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8974    2.7620    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 13 20  4  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 10 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4842

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=C(SC)SC(I)=C3)C(=O)CC(C)(C)C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.798

>  <W2 Pf proliferation inhibition EC50 uM>
0.2866

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.01459854

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4844
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -0.5837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489    0.8152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227    1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    1.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175    3.0199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483    2.5100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 14 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
 30 31  4  0  0  0  0
 13 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4844

>  <JC_XSMILES>
CN(C)C(=O)OC1=CC=CC=C1C2=C(NC(C)(C)CC(C)(C)C)N3C=CC(C)=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.576

>  <W2 Pf proliferation inhibition EC50 uM>
0.02851

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.047169811

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4845
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 12 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 17 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  4  0  0  0  0
 24 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4845

>  <JC_XSMILES>
CCOC1=CC(=CC(Cl)=C1O)C2CC(=O)NC3=C2C(=O)CC(C3)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.612

>  <W2 Pf proliferation inhibition EC50 uM>
0.2848

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4849
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
  6 11  4  0  0  0  0
  3 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 12 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4849

>  <JC_XSMILES>
OC1=C(C=CC2=CC=CN=C12)C(NC3=CC=CC=N3)C4=CC=C(Br)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.358

>  <W2 Pf proliferation inhibition EC50 uM>
0.2839

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.112676056

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4851
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 23 29  4  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4851

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC(Br)=C4)C(=O)OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2337

>  <W2 Pf proliferation inhibition EC50 uM>
0.0416

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.71

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4852
  Mrv1591402191617072D          

 39 44  0  0  0  0            999 V2000
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -1.0396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9719   -3.6945    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1514   -3.7807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8158   -3.0270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 15 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  4  0  0  0  0
  8 34  4  0  0  0  0
 25 34  4  0  0  0  0
  6 35  1  0  0  0  0
 35 36  1  0  0  0  0
 35 37  1  0  0  0  0
  3 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4852

>  <JC_XSMILES>
COC1COC(OC2=C3COC(=O)C3=C(C4=CC=C5OCOC5=C4)C6=CC(OC)=C(OC)C=C26)C(O)C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0817

>  <W2 Pf proliferation inhibition EC50 uM>
0.02826

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.276923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4853
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    1.3222   -0.8866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -2.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -2.6090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -3.3937    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -3.3937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -4.0611    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -2.6090    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -2.3541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0284   -2.9061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8131   -2.6512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9846   -1.8442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7692   -1.5893    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9407   -0.7823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1123    0.0247    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7477   -0.9538    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1338   -0.6108    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3715   -1.2922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4131   -1.5471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4888   -2.3541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6603   -1.5471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1019   -2.9061    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5498   -3.5192    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6539   -2.2930    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7150   -3.4582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4996   -3.2032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1127   -3.7552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9411   -4.5622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5542   -5.1143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1565   -4.8172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5434   -4.2651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  2  0  0  0  0
  6  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 12 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  4  0  0  0  0
  4 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   5
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4853

>  <JC_XSMILES>
CCC1=C(NC(=O)N1C2=CC=C(OC(F)(F)F)C=C2)C(C)S(=O)(=O)C3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0478

>  <W2 Pf proliferation inhibition EC50 uM>
0.01622

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.75

>  <Powder data?>
No

>  <IFI value>
0.012195122

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4857
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4857

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C=CC(Cl)=CC2=C1NCCCN(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.826

>  <W2 Pf proliferation inhibition EC50 uM>
0.1354

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.21

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4858
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
  2 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 29 32  1  0  0  0  0
 32 33  2  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 32 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4858

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)C3=NCCCN3)NC4=CC=C(C=C4)C5=NCCCN5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0344

>  <W2 Pf proliferation inhibition EC50 uM>
0.0204

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>7.28

>  <Powder data?>
No

>  <IFI value>
0.035087719

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4859
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -4.4120    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1946   -1.8980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0339   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8186   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9901   -2.4922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7747   -2.2373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3770   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5924   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5485   -1.1332    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.9354   -0.5812    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.3331   -0.8783    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
M  CHG  2  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4859

>  <JC_XSMILES>
CN1N=CC(I)=C1C(=O)NC2=CC=C(C)C(=C2)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1922

>  <W2 Pf proliferation inhibition EC50 uM>
0.2801

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4860
  Mrv1591402191617072D          

 43 47  0  0  0  0            999 V2000
    0.3391    3.5800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5941    2.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0421    2.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4011    2.6239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9531    3.2371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7600    3.0656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0150    2.2809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4630    1.6678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7180    0.8832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1660    0.2701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5250    0.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6560    1.8393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1040    1.2262    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2970    1.3977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3704    1.8826    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2550    0.7846    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0619    0.9561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3169    1.7407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1239    1.9122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3789    2.6968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8269    3.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0199    3.1384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7649    2.3538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8580   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4291   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7143   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4288   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1433   -2.8876    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  8 12  4  0  0  0  0
  4 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 16 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  2  0  0  0  0
 34 36  4  0  0  0  0
 26 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  1  0  0  0  0
 40 42  4  0  0  0  0
 42 43  4  0  0  0  0
 37 43  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4860

>  <JC_XSMILES>
CC(C)C1=CC=CC(C(C)C)=C1NC(=O)N(CC2=CC=CC=C2)C(C)C3=NC4=CC=CC=C4C(=O)N3C5=CC=C(Br)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.322

>  <W2 Pf proliferation inhibition EC50 uM>
0.02798

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4863
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -1.3144    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 12 26  1  0  0  0  0
 21 26  4  0  0  0  0
 13 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 27 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4863

>  <JC_XSMILES>
CCC1=CC=CC=C1NC(=O)C2C(N(CC(C)C)C(=O)C3=CC=CC=C23)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.364

>  <W2 Pf proliferation inhibition EC50 uM>
0.2701

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>97.18

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4865
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  6 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 15 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4865

>  <JC_XSMILES>
CCOC1=CC(=CC(Br)=C1OCC)C2C(=CNC=C2C(=O)OC)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.388

>  <W2 Pf proliferation inhibition EC50 uM>
0.2773

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4866
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
  9 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4866

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(C2=CC=C(C=C2)N(C)C)C3=CC=C(C=C3)N(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.353

>  <W2 Pf proliferation inhibition EC50 uM>
0.2771

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.136363636

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4868
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3058    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8933    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0863    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
  4 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 13 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 12 27  1  0  0  0  0
 27 28  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4868

>  <JC_XSMILES>
CC(=O)N(C1=CC=CC=C1C)C2=C(N3CCCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0839

>  <W2 Pf proliferation inhibition EC50 uM>
0.0319

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.53

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4869
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    5.6424   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.5396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.9979    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1806    3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.5306    3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -0.1006    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -0.5422    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507   -1.9399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957   -2.7246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6112   -2.8961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1633   -2.2830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9702   -2.4545    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083   -1.4984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604   -0.8853    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 14 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 27 33  4  0  0  0  0
 33 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4869

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2=NC3=C(C=NN3C(=C2)C(F)(F)F)C(=O)NC4=CC=CC(Cl)=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
2.606

>  <W2 Pf proliferation inhibition EC50 uM>
0.2747

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4872
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -1.3523   -6.4519    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1728   -6.5381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5083   -7.2918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3288   -7.3780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8137   -6.7106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4782   -5.9569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6577   -5.8707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3221   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7346   -4.4025    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1826   -3.7894    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5152   -4.9455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 17 26  4  0  0  0  0
 11 27  4  0  0  0  0
  8 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4872

>  <JC_XSMILES>
ClC1=CC=CC=C1C2=NSC(SCC(=O)NC3=CC=C4OCCOC4=C3)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.593

>  <W2 Pf proliferation inhibition EC50 uM>
0.273

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4873
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8653    0.4014    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 19 26  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4873

>  <JC_XSMILES>
COC1=CC=CC(=C1)C(=O)NCc2n[nH]c(=S)n2C3=CC=C(Cl)C(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2749

>  <W2 Pf proliferation inhibition EC50 uM>
0.2728

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4874
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -7.8592    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
 10  9  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 18 31  4  0  0  0  0
 31 32  4  0  0  0  0
 15 32  4  0  0  0  0
  9 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
  6 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4874

>  <JC_XSMILES>
CCN(CC)C1=CC=C(C=NNC(=O)C2=CC=C(NC3=NC(=CS3)C4=CC=CC=C4)C=C2)C(O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1511

>  <W2 Pf proliferation inhibition EC50 uM>
0.0548

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.12

>  <Powder data?>
Yes

>  <IFI value>
0.272727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4875
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -1.3144    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  3  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 15 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 13 27  1  0  0  0  0
 22 27  4  0  0  0  0
 14 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 28 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4875

>  <JC_XSMILES>
COC1=CC=C(Cl)C=C1NC(=O)C2C(N(CC(C)C)C(=O)C3=CC=CC=C23)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.837

>  <W2 Pf proliferation inhibition EC50 uM>
0.2721

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.090909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4876
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  3  0  0  0  0
 19 24  1  0  0  0  0
 24 25  1  0  0  0  0
 16 25  1  0  0  0  0
 14 26  4  0  0  0  0
  9 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4876

>  <JC_XSMILES>
CC(C)(C)CC(C)(C)C1=CC=C(O)C(CN2CCN(CCC#N)CC2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.287

>  <W2 Pf proliferation inhibition EC50 uM>
0.2717

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4878
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    3.6959    0.4515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9509   -0.3331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7578   -0.5046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0128   -1.2893    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5278   -1.9567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7028   -1.9567    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.2903   -2.6712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4653   -2.6712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0528   -1.9567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0528   -3.3856    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3884   -4.1393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1954   -4.3108    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7753   -4.6913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0608   -4.2788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2762   -4.5338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3369   -3.9818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1654   -3.1748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6193   -2.9198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2324   -3.4719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0128   -2.6241    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7974   -2.3692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7974   -1.5442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5119   -1.1317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5119   -0.3067    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2263   -1.5442    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9408   -1.1317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2263   -2.3692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9408   -2.7817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5119   -2.7817    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5119   -3.6067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  1  0  0  0  0
 14 19  4  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  4 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  2  0  0  0  0
 23 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  2  0  0  0  0
 27 29  4  0  0  0  0
 21 29  4  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4878

>  <JC_XSMILES>
CCCN1C(SCC(=O)N2C(C)CC3=CC=CC=C23)=NC4=C1C(=O)N(C)C(=O)N4C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
<0.0271

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.03539823

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4880
  Mrv1591402191617072D          

 41 46  0  0  0  0            999 V2000
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3428   -1.8076    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0702   -3.9674    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5551   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3801   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7926   -4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3801   -4.7289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7926   -5.4434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6176   -5.4434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0301   -4.7289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6176   -4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0301   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0702   -2.6326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3251   -1.8479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  4  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 11 20  4  0  0  0  0
 20 21  2  0  0  0  0
 20 22  4  0  0  0  0
  9 22  4  0  0  0  0
 22 23  1  0  0  0  0
  6 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 24 35  4  0  0  0  0
 30 35  4  0  0  0  0
  7 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 36 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4880

>  <JC_XSMILES>
CCOC(=O)C1=C(N=c2sc(=CC3=CC=CC=C3O)c(=O)n2C1C4=C(OC)C=CC5=CC=CC=C45)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
2.316

>  <W2 Pf proliferation inhibition EC50 uM>
0.2706

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4882
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -0.7145    2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    1.7605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    3.1895    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
  9 25  4  0  0  0  0
  5 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4882

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(NC(=S)N2CCSC2C3=CC=C(Br)C=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2173

>  <W2 Pf proliferation inhibition EC50 uM>
0.1165

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
43.33

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4883
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 12 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 20 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4883

>  <JC_XSMILES>
COC1=CC=CC(=C1)C(=O)NC(C2=CC=C(Cl)C=C2)C3=CC(Cl)=C4C=CC=NC4=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.312

>  <W2 Pf proliferation inhibition EC50 uM>
0.268

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4884
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    8.9339    9.2222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3019    8.6919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5266    8.9741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3834    9.7866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6081   10.0687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8947    8.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0379    7.6313    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8132    7.3492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9564    6.5367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3244    6.0064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9564    5.4761    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5492    6.2886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4059    7.1010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9119    5.2919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3244    4.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9119    3.8630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0869    3.8630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5349    3.2499    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8675    4.4059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6744    4.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0869    5.2919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 19 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 29 33  4  0  0  0  0
 33 34  4  0  0  0  0
 26 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4884

>  <JC_XSMILES>
CCC(CC)CN1CCC(O)(CC1)C2=CC=C3OC(=CC3=C2)C(=O)NC4=CC=C5OCOC5=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2463

>  <W2 Pf proliferation inhibition EC50 uM>
0.268

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034782609

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4885
  Mrv1591402191617072D          

 44 48  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.2999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1060    3.7987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8578    0.8249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8078    0.4838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8580   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4291   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7146   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4288   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1433   -2.8876    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4288   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 16 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
  3 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  2  0  0  0  0
 35 37  4  0  0  0  0
 27 37  4  0  0  0  0
 37 38  1  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  1  0  0  0  0
 41 43  4  0  0  0  0
 43 44  4  0  0  0  0
 38 44  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4885

>  <JC_XSMILES>
CCC(N(CC1=CC=CC=C1)C(=O)NC2=C(C=CC=C2C(C)C)C(C)C)C3=NC4=CC=CC=C4C(=O)N3C5=CC=C(Cl)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.423

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009174312

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4886
  Mrv1591402191617072D          

 28 29  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184   -4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684   -4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7474  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -14.4375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4886

>  <JC_XSMILES>
FC(F)(F)C1=CC=C(N=C1)S(=O)(=O)CC(=O)NNS(=O)(=O)C2=CC=C(Cl)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.344

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009090909

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4888
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    1.2850   -6.8423    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.0902   -6.0406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2986   -5.8084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1038   -5.0068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7007   -4.4372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4923   -4.6694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6871   -5.4711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5059   -3.6356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1028   -3.0660    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2858   -3.4034    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4806   -2.6017    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -1.6585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5873   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -0.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -1.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2722   -2.3696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8691   -2.9391    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4670   -1.5679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2587   -1.3358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4535   -0.5341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8566    0.0354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0514    0.8371    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0649   -0.1967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8701   -0.9984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 15 21  1  0  0  0  0
 14 15  1  0  0  0  0
 13 14  1  0  0  0  0
 12 20  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
 17 19  1  0  0  0  0
 16 17  1  0  0  0  0
 19 20  1  0  0  0  0
 13 18  1  0  0  0  0
 15 16  1  0  0  0  0
 11 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4888

>  <JC_XSMILES>
FC1=CC=C(C=C1)C(=O)ON(C2C3CC4CC(C3)CC2C4)C(=O)C5=CC=C(F)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4889
  Mrv1591402191617072D          

 23 23  0  0  0  0            999 V2000
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    0.3020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -1.1270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -1.1270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    0.3020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  9 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
  4 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4889

>  <JC_XSMILES>
CC(=O)C(=NNC1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.014492754

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-489
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -4.9820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -5.6495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -6.4032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -7.0706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -6.9844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -7.6518    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -6.2307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -5.5632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3390   -4.8096    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -3.9425    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -3.1355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -2.8806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -3.4326    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -4.2396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -4.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5204   -3.1777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6919   -2.3707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4765   -2.1158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0896   -2.6678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8743   -2.4128    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0458   -1.6059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9181   -3.4748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1335   -3.7297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
  7 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 22 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  4  0  0  0  0
 25 32  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-489

>  <JC_XSMILES>
CCOC(=O)C1=C(NC(=C1)C2=CC=C(Cl)C=C2Cl)N3CCN(CC3)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.368

>  <W2 Pf proliferation inhibition EC50 uM>
>1.728

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>13.4

>  <Powder data?>
No

>  <IFI value>
0.007936508

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4890
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -0.3121   -4.1696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9252   -3.6175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -2.8106    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -2.1975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1262   -2.2837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6111   -1.6163    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4316   -1.7025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7671   -2.4562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5876   -2.5424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0726   -1.8750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8930   -1.9612    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -4.7370   -1.1213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9165   -1.0351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -1.4830    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -1.6545    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
  4 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  3 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 22 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4890

>  <JC_XSMILES>
CCN1C(CNC2=CC=C(Cl)C=C2)=NN=C1SCC(=O)NC3=CC=CC(C)=C3C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4894
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7311   -5.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1436   -6.6449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5916   -7.2580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8379   -6.9225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9241   -6.1020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4894

>  <JC_XSMILES>
CCN(CC)C(=O)C1=CN(N=N1)C2CCN(CC2)CC3=CC=CO3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017699115

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4896
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4915   -5.0307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8270   -5.7844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2139   -6.3364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3002   -7.1569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4995   -5.9239    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4896

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2=NC3=CC=CC=C3N2C4CCN(CC4)CC5=CC=C(C)O5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009615385

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4897
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 22  4  0  0  0  0
  7 22  4  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4897

>  <JC_XSMILES>
CCN(CC)CC1=CC2=CC=C(C)C=C2N(CC(=O)OC)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.01

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-490
  Mrv1591402191617072D          

 30 35  0  0  0  0            999 V2000
    6.1088    3.7250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9528    4.3924    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7732    4.4787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1857    5.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7732    5.9076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1857    6.6221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0107    6.6221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4232    5.9076    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0107    5.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  4  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  1  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  5 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 21 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1   1
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  20
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-490

>  <JC_XSMILES>
N1C2=CC=C(C=C2N=C1C3=CC=CN=C3)C4=CC=C5NC(=NC5=C4)C6=CC=CN=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
1.414

>  <W2 Pf proliferation inhibition EC50 uM>
1.287

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4902
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    2.2105    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0332    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4980    2.3620    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3912    0.9370    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2162    0.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5741    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1094    2.3620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4673    3.1053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2900    3.1669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7548    2.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3968    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6480    3.9102    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4707    3.9719    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.1832    4.5919    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7305    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5470   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1517   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9401   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1237   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5189    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7025    1.3395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8037   -0.8703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0604   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4556   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6673   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4837   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0884    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8768    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
  5 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 20 21  2  0  0  0  0
 16 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
  4 28  1  0  0  0  0
 23 28  4  0  0  0  0
M  CHG  2  12   1  13  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4902

>  <JC_XSMILES>
CC(=O)N1C(C2=CC=C(C=C2)[N+]([O-])=O)C3=C(CCCC3=O)NC4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.05

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4903
  Mrv1591402191617072D          

 44 48  0  0  0  0            999 V2000
   -9.4460   -4.5837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.6391   -4.7552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0870   -4.1421    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3420   -3.3575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7899   -2.7444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2801   -4.3137    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4516   -5.1206    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1085   -3.5067    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4731   -4.4852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9211   -3.8721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1141   -4.0436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8591   -4.8283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4112   -5.4413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2182   -5.2698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0522   -4.9998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7972   -5.7844    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5001   -4.3867    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6932   -4.5582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1411   -3.9451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3127   -3.1381    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5982   -2.7256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3207   -4.0314    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9082   -4.7458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0832   -4.7458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3293   -5.4603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0832   -6.1748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9082   -6.1748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3207   -5.4603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1457   -5.4603    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5582   -6.1748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 27 35  1  0  0  0  0
 30 35  4  0  0  0  0
 22 36  4  0  0  0  0
 19 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
 42 43  1  0  0  0  0
 43 44  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4903

>  <JC_XSMILES>
CCN(CC)S(=O)(=O)C1=CC=C(C=C1)C(=O)NCC2=NN=C(SCC(=O)N3CCC4=CC=CC=C34)N2C5=CC=CC=C5OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4904
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.3739    2.3234    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0300    4.1626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8370    3.9911    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919    3.2065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3890    4.6042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1341    5.3888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6861    6.0019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4931    5.8304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7480    5.0458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1960    4.4327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  5 13  4  0  0  0  0
 13 14  2  0  0  0  0
  2 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4904

>  <JC_XSMILES>
O=C(CCn1c2ccccc2oc1=S)N3CCN(CC3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.044117647

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4905
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    3.5724    1.2375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8653    0.4014    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  9  5  1  4  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 10 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 16 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4905

>  <JC_XSMILES>
FC1=CC=C(C=C1Cl)N=C2SCC(=O)N2C3=CC=C(F)C(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4906
  Mrv1591402191617072D          

 19 19  0  0  0  0            999 V2000
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4906

>  <JC_XSMILES>
CCCCCCCCC(=O)NC1=C(C)C=CC=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009615385

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4907
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -4.5888    7.7270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8743    8.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8743    8.9645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599    9.3770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4454    8.9645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4454    8.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599    7.7270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309    7.7270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309    6.9020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164    8.1395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020    7.7270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    8.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    7.7270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    6.9020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    6.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020    6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414    6.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414    5.6645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    5.2520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    5.2520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4907

>  <JC_XSMILES>
FC1=CC=CC(=C1)C(=O)NC2CCN(CC2)CC(=O)NC3CC3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.015873016

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4910
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -1.3099    0.6720    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.5955    0.2595    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.1190    0.6720    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5955   -0.5655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -0.9780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -1.8030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5955   -2.2155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -1.8030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -0.9780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5955   -3.0405    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0720   -3.5254    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -4.3100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0080   -4.3100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4929   -4.9774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2379   -5.7621    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9054   -6.2470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5728   -5.7621    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3179   -4.9774    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9054   -7.0720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1909   -7.4845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1909   -8.3095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9054   -8.7220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9054   -9.5470    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.6198   -8.3095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6198   -7.4845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2629   -3.5254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0475   -3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8321   -3.0155    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7926   -2.4858    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3025   -4.0551    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 13 26  4  0  0  0  0
 10 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4910

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)N2N=CC(C3=NC(=NO3)C4=CC=C(Cl)C=C4)=C2C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.208

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.00862069

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4911
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
   -2.2216    0.2288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8345    0.5720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0418    0.3432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5526    0.9153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3453    0.6864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9398    1.2585    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7416    2.0593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3361    2.6314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1287    2.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9490    2.2881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3545    1.7161    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4381    1.9449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0326    1.3729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8253    1.6017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0234    2.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.9746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6363    2.7458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0418    3.3178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2400    4.1186    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7508    3.0890    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3453    3.6610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1471    4.4619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7416    5.0339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5342    4.8051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1287    5.3771    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.7324    4.0042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1379    3.4322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7324    1.0297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3269    1.6017    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9305    0.2288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7232    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9213   -0.8008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7140   -1.0297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9121   -1.8305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3177   -2.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5250   -2.1737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3269   -1.3729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
  7 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4911

>  <JC_XSMILES>
CCCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=C(Cl)C=C3)C(=O)CCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.161

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4912
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    2.0367    1.0527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.2902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1331    0.5678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8781   -0.2169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0531   -0.2169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7982    0.5678    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    2.2902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    3.5277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6791    3.5277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4327    3.1921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9848    3.8052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5723    4.5197    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7653    4.3482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    3.5277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.5277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 13 23  4  0  0  0  0
 23 24  4  0  0  0  0
 10 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4912

>  <JC_XSMILES>
O=C(NCC1CCCO1)C2=CN=C(NCCCN3C=CN=C3)N=C2NCCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.012

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.00952381

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4916
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  7 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  6 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4916

>  <JC_XSMILES>
NC1=NC(N)=C2C(OC3=CC=CC=C3)=CC=CC2=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.448

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4917
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    3.3629    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6484    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6484    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    3.9855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6484    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6484    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3629    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3629    3.9855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0774    5.2230    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7918    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5063    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2208    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2208    3.9855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5063    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7918    3.9855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
  2 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 21 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4917

>  <JC_XSMILES>
OC(COC1=CC=CC=C1C(=O)NC2=CC=CC=C2)CN3C4=CC=CC=C4C5=CC=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2815

>  <W2 Pf proliferation inhibition EC50 uM>
0.2669

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-493
  Mrv1591402191617072D          

 28 29  0  0  0  0            999 V2000
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
  8 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  6 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-493

>  <JC_XSMILES>
CC(C)CNC1=NC(NCCCN(C)C)=NC=C1C(=O)NCC2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3157

>  <W2 Pf proliferation inhibition EC50 uM>
>1.286

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.02020202

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4932
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3848   -1.0942    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8545   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1367   -2.7880    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.0793   -2.2949    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.6298   -1.7306    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
  6 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
 10 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4932

>  <JC_XSMILES>
CC1=CC(C)=C2C(=O)CC(N)(OC2=C1)C(Cl)(Cl)Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.435

>  <W2 Pf proliferation inhibition EC50 uM>
0.2605

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4933
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9139   -2.3174    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9441   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7511   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1636   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6116   -1.3144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
  4 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  2  0  0  0  0
 15 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 13 25  1  0  0  0  0
  2 25  1  0  0  0  0
  3 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 29 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4933

>  <JC_XSMILES>
CC1=C(C(C2=CC=CC=C2F)C3=C(CC(CC3=O)C4=CC=CC=C4)N1)C(=O)OC5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.541

>  <W2 Pf proliferation inhibition EC50 uM>
0.2593

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034883721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4938
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -2.0600   -7.4378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3455   -7.8503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6310   -7.4378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0834   -7.8503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7979   -7.4378    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5124   -7.8503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5124   -8.6753    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2268   -7.4378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9413   -7.8503    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6558   -7.4378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3702   -7.8503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1239   -7.5148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2955   -6.7078    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7434   -6.0947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1559   -5.3802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9629   -5.5518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0491   -6.3722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6760   -8.1279    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2635   -8.8423    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4565   -8.6708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4964   -8.0416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8320   -7.2880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6525   -7.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1374   -7.8692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8018   -8.6228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9814   -8.7091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4938

>  <JC_XSMILES>
CCCCNC(=O)CSCC1=C(N2C=CC=C2)N(N=C1)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2531

>  <W2 Pf proliferation inhibition EC50 uM>
0.257

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4939
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 11 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4939

>  <JC_XSMILES>
CCCN1CCC(CC1)NC(C2=CC=CC=C2)C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.753

>  <W2 Pf proliferation inhibition EC50 uM>
0.0519

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.21

>  <Powder data?>
Yes

>  <IFI value>
0.016129032

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-494
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6425    1.0799    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6425   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  2  0  0  0  0
 14 16  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  4 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
  2 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-494

>  <JC_XSMILES>
O=C1C=C(CSC2=NC3=C(SC=C3)C(=O)N2CC4=CC=CC=C4)N=C5C=CC=CN15

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.285

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4943
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    0.3020    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -1.1270    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  9 12  4  0  0  0  0
 12 13  4  0  0  0  0
  3 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  2  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4943

>  <JC_XSMILES>
COC1=C2OC=CC2=C(OC)C3=C1OC(=CC3=O)C(Cl)(Cl)Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.646

>  <W2 Pf proliferation inhibition EC50 uM>
0.2545

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.040540541

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4944
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 22 23  2  0  0  0  0
  9 24  4  0  0  0  0
 24 25  4  0  0  0  0
  6 25  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4944

>  <JC_XSMILES>
CCOC(=O)C1=CC=C(NCC2=C(C)NC3=CC=CC=C3C2=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.342

>  <W2 Pf proliferation inhibition EC50 uM>
0.2542

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4945
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    0.5597   -2.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9943   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6043   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0390   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8636   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2982    0.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9082    1.3045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0836    1.3302    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3428    2.0057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0309    2.7695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6610    3.3021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3622    2.8675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1656    2.0663    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1228    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0049    1.3683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9064    0.8095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -0.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3140   -0.3719    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3745   -1.1947    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6108   -1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4141   -2.3078    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0781   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2535   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8189   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
  6 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  2  0  0  0  0
 20 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
  5 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4945

>  <JC_XSMILES>
CC1=CC=C2N(C(=O)C3=CC=CO3)C(C)(C)c4ssc(=S)c4C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2758

>  <W2 Pf proliferation inhibition EC50 uM>
0.2542

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.007462687

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4949
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  3 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 11 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
  2 25  1  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4949

>  <JC_XSMILES>
O=C1C(NC2CCCCC2)=C(N3CCOCC3)C(=O)C4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1386

>  <W2 Pf proliferation inhibition EC50 uM>
0.1158

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
46.08

>  <Powder data?>
Yes

>  <IFI value>
0.037593985

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4952
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    1.4229   -2.4457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4758    0.3498    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2828    0.5213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5377    1.3059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3447    1.4774    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5996    2.2621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4066    2.4336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9586    1.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7037    1.0359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8967    0.8644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
  8 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  7 21  4  0  0  0  0
 21 22  4  0  0  0  0
  5 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4952

>  <JC_XSMILES>
CC1=CC=C2NC3=C(NCCN4CCCCC4)N=CN=C3C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2163

>  <W2 Pf proliferation inhibition EC50 uM>
0.099

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
39.71

>  <Powder data?>
Yes

>  <IFI value>
0.1

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4954
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0300    4.1626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8370    3.9911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919    3.2065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8989    3.0350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 12 18  4  0  0  0  0
  7 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4954

>  <JC_XSMILES>
CC(=O)C1=C(C)N(CC(=O)NC2=CC=CC(C)=C2)C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.329

>  <W2 Pf proliferation inhibition EC50 uM>
0.2484

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4957
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    6.5925   -4.8418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8546   -4.4728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1661   -4.9273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8053   -3.6493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4938   -3.1948    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0674   -3.2803    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4148   -3.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6133   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2665   -2.8408    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6355   -2.1029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -1.4898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2765   -1.6613    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7245   -1.0482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9175   -1.2198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3655   -0.6067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4415   -0.7782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9935   -0.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7386    0.6195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0684    0.7910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6204    0.1779    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3385   -0.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1454   -0.5337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6975   -1.1468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4425   -1.9314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0798   -2.4553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4004    0.2510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9154    0.9184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4004    1.5858    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1850    1.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    1.7434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6139    1.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6139    0.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    0.0934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1850    0.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 10 24  4  0  0  0  0
 24 25  1  0  0  0  0
  6 25  1  0  0  0  0
 22 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 26 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4957

>  <JC_XSMILES>
CC(C)C(=O)N1CCOC2=C(OCCC3=CC=CC=N3)C=C(C=C2C1)C4=CSC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1828

>  <W2 Pf proliferation inhibition EC50 uM>
0.1247

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
50.58

>  <Powder data?>
Yes

>  <IFI value>
0.019230769

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4958
  Mrv1591402191617072D          

 23 27  0  0  0  0            999 V2000
    1.9289   -4.8850    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9288   -4.0600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1934   -4.4337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6428   -3.6434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3783   -4.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1139   -3.6434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6644   -4.4337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1139   -2.8960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3783   -2.5223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6428   -2.8960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9288   -3.3126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3783   -1.6973    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7108   -1.2124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9658   -0.4278    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7908   -0.4278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3428    0.1853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1497    0.0138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4047   -0.7708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8527   -1.3839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0457   -1.2124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0878    0.9700    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.2808    1.1415    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.6398    1.5831    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
  2  7  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  4 10  1  0  0  0  0
  6  8  1  0  0  0  0
  2 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 15 20  4  0  0  0  0
 16 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
M  CHG  2  21   1  22  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4958

>  <JC_XSMILES>
OC12CC3CC(C1)CC(C3)(C2)N4N=NC5=C(C=CC=C45)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.536

>  <W2 Pf proliferation inhibition EC50 uM>
0.2451

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-496
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
  5 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-496

>  <JC_XSMILES>
OC1=CC=C(C=C1CN2CCCCC2)C3=NC4=CC=CC=C4S3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.139

>  <W2 Pf proliferation inhibition EC50 uM>
0.786

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.13

>  <Powder data?>
No

>  <IFI value>
0.11965812

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4960
  Mrv1591402191617072D          

 17 20  0  0  0  0            999 V2000
    0.2029   -3.9896    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1709   -3.2541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9675   -3.0397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1802   -2.2426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5962   -1.6599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2004   -1.8742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4131   -2.6713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1478   -3.0467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9183   -2.7518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0482   -1.9371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8187   -1.6423    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4593   -2.1621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3294   -2.9768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5589   -3.2717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4290   -4.0864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6585   -4.3812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0179   -3.8614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  4  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  1 17  4  0  0  0  0
  8 17  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   1
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4960

>  <JC_XSMILES>
N1C2=CC=CC=C2C3=C4C=NC=CC4=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0853

>  <W2 Pf proliferation inhibition EC50 uM>
0.02423

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4961
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
  6 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
  5 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 23 24  4  0  0  0  0
  3 24  4  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4961

>  <JC_XSMILES>
COC1=CC(C2CC(=O)NC(C)=C2C(=O)OC(C)C)=C(OC)C=C1Br

>  <PF proliferation inhibition 3D7 EC50 uM>
1.031

>  <W2 Pf proliferation inhibition EC50 uM>
0.242

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4962
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
  7 18  4  0  0  0  0
 18 19  4  0  0  0  0
  4 19  4  0  0  0  0
M  CHG  1   7   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4962

>  <JC_XSMILES>
CN(C)C1=CC=[N+](CC(=O)C2=CC=C(Br)C=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2109

>  <W2 Pf proliferation inhibition EC50 uM>
0.1828

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
75.61

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4964
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
    0.6985    5.8150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5235    5.8150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9360    5.1005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7610    5.1005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3131    4.4874    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9805    5.6434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5936    6.1955    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3782    5.9405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1233    5.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6332    6.7251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1629    5.6856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7760    6.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3890    6.7896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3280    5.6245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2239    6.8507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1735    5.8150    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7610    6.5294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9360    6.5294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 32 36  4  0  0  0  0
 36 37  4  0  0  0  0
 29 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4964

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4=CC=C5OCOC5=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.831

>  <W2 Pf proliferation inhibition EC50 uM>
0.02413

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028037383

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4965
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    2.2396    1.8959    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    3.1334    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    4.3709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    4.7834    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975    4.3709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5205    3.6834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5205    4.2334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3328    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0472    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0472    4.3709    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3328    4.7834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3328    5.6084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    6.0209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    6.8459    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    5.6084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    4.7834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    4.3709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
  5 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 18 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4965

>  <JC_XSMILES>
OC1=CC=C(C=C1CNC2CN3CCC2CC3)C4=CC=NC5=CC(Cl)=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.986

>  <W2 Pf proliferation inhibition EC50 uM>
<0.02412

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008547009

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4967
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  8 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4967

>  <JC_XSMILES>
CCCCC(=O)NC(C1=CC=CC=C1)C2=CC=C3C=CC=NC3=C2O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.387

>  <W2 Pf proliferation inhibition EC50 uM>
0.2393

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-497
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4748   -3.9898    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -3.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1661   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9866   -3.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -2.9774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1426   -2.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8372   -2.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0168   -2.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-497

>  <JC_XSMILES>
CCC(=O)N1CCN(C1)C(=O)C2=CC=C(C)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.501

>  <W2 Pf proliferation inhibition EC50 uM>
1.281

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4972
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -3.7045   -3.7297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -3.1777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -3.4326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -2.8806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -3.1355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -3.9425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -4.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -4.2396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -4.1974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -4.1974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -4.9820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -5.6495    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -5.5632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 13 22  4  0  0  0  0
 17 22  4  0  0  0  0
 10 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
  9 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4972

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2C(COC3=CC=CC4=CC=CC=C34)=NN=C2SC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.524

>  <W2 Pf proliferation inhibition EC50 uM>
0.2365

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.028301887

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4973
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
   -3.4717   -2.1976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0237   -2.8107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8307   -2.6391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3827   -3.2522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1897   -3.0807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4446   -2.2961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8926   -1.6830    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0856   -1.8545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6647   -2.3691    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1127   -1.7560    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3676   -0.9714    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8156   -0.3583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0086   -0.5298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -1.3144    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -2.6420    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  1  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 14 18  4  0  0  0  0
 15 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
 19 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4973

>  <JC_XSMILES>
C(CC1=CC=CN=C1)NC2=NC=CN3C(=CN=C23)C4=CC=C5C=CC=CC5=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1154

>  <W2 Pf proliferation inhibition EC50 uM>
0.0812

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
34.35

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4980
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -0.7238    5.7312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3882    4.9775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4188    4.8060    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2487    3.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4202    2.8430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007    4.2631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6212    4.1768    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  9 23  4  0  0  0  0
 17 23  4  0  0  0  0
  4 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
  2 26  4  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4980

>  <JC_XSMILES>
CC1=NN(CC(O)CN2C3=CC=C(Br)C=C3C4=CC(Br)=CC=C24)C(C)=C1Br

>  <PF proliferation inhibition 3D7 EC50 uM>
0.769

>  <W2 Pf proliferation inhibition EC50 uM>
0.1772

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
75.15

>  <Powder data?>
Yes

>  <IFI value>
0.034883721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4982
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    6.1368    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2525    0.4595    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0371    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0371    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7046    2.0244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2525    1.7944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4982

>  <JC_XSMILES>
CC(C)C1=CC=C(C=C1)N(C)C2=NC(C)=NC3=C2C(C)=C(S3)C(=O)NC4=NOC(C)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2481

>  <W2 Pf proliferation inhibition EC50 uM>
0.2355

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011764706

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4983
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2495    0.0862    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231    1.0550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964    1.3099    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2550    0.7846    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 11 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  9 21  1  0  0  0  0
 18 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 10 27  1  0  0  0  0
  6 27  2  0  0  0  0
 27 28  1  0  0  0  0
  7 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4983

>  <JC_XSMILES>
CCOC(=O)C1C(CC2=C(C(C3=C(C)C=CS3)C(=C(C)N2)C(=O)OCC)C1=O)C4=CC=CC=C4OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.984

>  <W2 Pf proliferation inhibition EC50 uM>
0.2351

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034883721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4987
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400   -4.0623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0470   -4.2338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5990   -3.6207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3441   -2.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
  3 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4987

>  <JC_XSMILES>
OCC1=NC2=CC=CC=C2N1CCOC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.0233

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.007936508

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4989
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4989

>  <JC_XSMILES>
OCC1CCCCN1CC2=CC(=CC=C2O)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.034

>  <W2 Pf proliferation inhibition EC50 uM>
<0.02325

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008403361

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4992
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  8 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  7 24  4  0  0  0  0
 24 25  4  0  0  0  0
  4 25  4  0  0  0  0
 20 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4992

>  <JC_XSMILES>
CN(C)C1=CC=C2N(C(=O)C3=CC=CC=C3)C4=CC=C(C=C4SC2=C1)N(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2177

>  <W2 Pf proliferation inhibition EC50 uM>
0.2319

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03875969

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4993
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 12 21  4  0  0  0  0
 11 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 25  1  0  0  0  0
 22 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 10 31  1  0  0  0  0
  6 31  2  0  0  0  0
 31 32  1  0  0  0  0
  7 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 36 39  4  0  0  0  0
 39 40  4  0  0  0  0
 33 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4993

>  <JC_XSMILES>
CCOC(=O)C1C(CC2=C(C(C3=CC=C(OC)C(OC)=C3)C(=C(C)N2)C(=O)OCC)C1=O)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2752

>  <W2 Pf proliferation inhibition EC50 uM>
0.1775

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>76.58

>  <Powder data?>
Yes

>  <IFI value>
0.046511628

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4996
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9638    0.0501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5159   -0.5630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1034   -1.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2964   -1.1059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
  9 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
  2 22  4  0  0  0  0
  6 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4996

>  <JC_XSMILES>
CN1N=C(C)C2=C(C)C(CCC(=O)N3CCCC3)=C(C)N=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.36

>  <W2 Pf proliferation inhibition EC50 uM>
<0.0158

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.85

>  <Powder data?>
No

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4998
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4369   -3.1745    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6918   -3.9591    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0244   -4.4440    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3570   -3.9591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5723   -4.2140    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5204   -0.7027    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 15 16  1  0  0  0  0
  7 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4998

>  <JC_XSMILES>
CCOC(=O)C1=C(N(N=N1)C2=NON=C2N)C3=CC=C(Br)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2871

>  <W2 Pf proliferation inhibition EC50 uM>
0.2298

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4999
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8810   -2.7050    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9908   -5.1657    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -4.3257    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6318   -4.9932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4522   -4.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9372   -5.5744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6016   -6.3281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0865   -6.9955    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.7811   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2962   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  2  0  0  0  0
 13 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4999

>  <JC_XSMILES>
CCOC1=CC=CC=C1n2c(N)c(sc2=S)C(=O)NC3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.968

>  <W2 Pf proliferation inhibition EC50 uM>
0.2295

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-500
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 18 29  4  0  0  0  0
 24 29  4  0  0  0  0
 11 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 34 37  4  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 37 40  4  0  0  0  0
 31 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-500

>  <JC_XSMILES>
COC1=CC=CC(=C1)C(=O)N(CCCC(C)NC2=CC(OC)=CC3=CC=CN=C23)CC4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.476

>  <W2 Pf proliferation inhibition EC50 uM>
0.513

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>4.01

>  <Powder data?>
No

>  <IFI value>
0.038095238

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5000
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
   -5.0013    7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    7.0125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8263    7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1763    7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592    8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592    9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   10.7250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881   11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881   11.9625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   11.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026   12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171   11.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315   12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.1460   11.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.8605   12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.8605   13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.1460   13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315   13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171   11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026   10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026    9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171    9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315    9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315   10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 27 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 18 40  4  0  0  0  0
 40 41  4  0  0  0  0
 15 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5000

>  <JC_XSMILES>
CS(=O)(=O)N1CCCCC1C(=O)NCC2=CC=C(OC3CCN(CC3)CC(C4=CC=CC=C4)C5=CC=CC=C5)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.022

>  <W2 Pf proliferation inhibition EC50 uM>
0.02287

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5002
  Mrv1591402191617072D          

 42 49  0  0  0  0            999 V2000
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
 13 22  4  0  0  0  0
  1 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 26 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 35 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 29 42  4  0  0  0  0
 33 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5002

>  <JC_XSMILES>
C(CN1CCN(CC1)C2=CC=NC3=CC4=CC=CC=C4C=C23)N5CCN(CC5)C6=CC=NC7=CC8=CC=CC=C8C=C67

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1765

>  <W2 Pf proliferation inhibition EC50 uM>
0.2283

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.081967213

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5003
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 19 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 24 34  4  0  0  0  0
 28 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5003

>  <JC_XSMILES>
CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CC3=CC(=CC=C3O)C4=CC=NC5=CC(Cl)=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
2.806

>  <W2 Pf proliferation inhibition EC50 uM>
0.2282

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5007
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
  9 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
  8 24  1  0  0  0  0
 24 25  2  0  0  0  0
  6 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5007

>  <JC_XSMILES>
OC1=CC=CC(NC2=C(N3CCCCC3)C(=O)C4=CC=CC=C4C2=O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.212

>  <W2 Pf proliferation inhibition EC50 uM>
0.2272

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5009
  Mrv1591402191617072D          

 32 37  0  0  0  0            999 V2000
    0.6009   -4.5382    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.0134   -3.8237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6009   -3.1092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0134   -2.3948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8384   -2.3948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2509   -3.1092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8384   -3.8237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2509   -1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0759   -1.6803    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4884   -0.9658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0759   -0.2513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2509   -0.2513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8384   -0.9658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0315   -0.7943    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9452    0.0262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2778    0.5111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3640    1.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1177    1.6672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7851    1.1822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6989    0.3618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4884   -2.3948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0759   -3.1092    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3134   -2.3948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7984   -3.0622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5830   -2.8073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2975   -3.2198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0119   -2.8073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7264   -3.2198    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    7.0119   -1.9823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2975   -1.5698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5830   -1.9823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7984   -1.7273    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
  8 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 15 20  4  0  0  0  0
  9 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
 31 32  4  0  0  0  0
 23 32  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5009

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C2N(CCC3=C2NC4=CC=CC=C34)C(=O)C5=CC6=CC(Br)=CC=C6O5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.887

>  <W2 Pf proliferation inhibition EC50 uM>
0.226

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-501
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
    6.2102    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0983    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5108    4.2999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089   -0.1271    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 16 17  1  0  0  0  0
  9 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 22  1  0  0  0  0
 11 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-501

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2CC(N3N=CN=C3N2C(=O)C4CC4)C5=CC=CC=C5Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
1.315

>  <W2 Pf proliferation inhibition EC50 uM>
>1.279

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5012
  Mrv1591402191617072D          

 28 33  0  0  0  0            999 V2000
    1.5663   -3.7210    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8518   -4.1335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8519   -4.9585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1374   -5.3710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.9586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.1336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -3.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -2.8960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -2.4835    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -1.6585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -1.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5873   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -0.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2915   -5.3711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2915   -6.1961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0059   -6.6087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7204   -6.1962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5050   -6.4512    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9900   -5.7838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5051   -5.1163    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7205   -5.3712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0060   -4.9587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 13 14  1  0  0  0  0
 12 17  1  0  0  0  0
 10 18  1  0  0  0  0
 16 17  1  0  0  0  0
 14 19  1  0  0  0  0
 16 18  1  0  0  0  0
 15 16  1  0  0  0  0
 10 19  1  0  0  0  0
 12 13  1  0  0  0  0
  5 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5012

>  <JC_XSMILES>
OC1=CC=C(C=C1CNC23CC4CC(CC(C4)C2)C3)C5=CC=C6OCOC6=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.832

>  <W2 Pf proliferation inhibition EC50 uM>
0.2253

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.017857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5015
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1118   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4618   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
  2 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5015

>  <JC_XSMILES>
CN(C(=O)CCNS(=O)(=O)C1=CC(Br)=CN=C1N)C2=CC=C(C)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.923

>  <W2 Pf proliferation inhibition EC50 uM>
0.224

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.025

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5016
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 14 29  4  0  0  0  0
  9 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5016

>  <JC_XSMILES>
COC1=CC=CC(=N1)C2=CC=C(O)C(CN3CCC(CC3)CC4=CC=CC=C4)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.306

>  <W2 Pf proliferation inhibition EC50 uM>
0.0861

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
38.45

>  <Powder data?>
Yes

>  <IFI value>
0.019230769

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5017
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.0146    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.9082    1.8876    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0832    3.3165    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
  8 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
  5 23  4  0  0  0  0
 23 24  4  0  0  0  0
  3 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5017

>  <JC_XSMILES>
CSC1=NN2C(C)=C(CC3=CC=CC(=C3)C(F)(F)F)C(C)=NC2=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2701

>  <W2 Pf proliferation inhibition EC50 uM>
0.2235

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.0125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5018
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
   -0.6678   -3.8802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7125   -3.0564    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0215   -2.6058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0662   -1.7820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6248   -1.3314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3606   -1.7045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1303   -1.4074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3063   -0.6014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0462   -0.2365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7928   -0.5875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9839   -1.3900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8008   -1.5054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1094   -2.2705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6011   -2.9203    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7842   -2.8050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4756   -2.0398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6507   -2.0476    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2026   -2.7403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4997   -3.5100    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4053   -2.5283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7143   -2.9789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7590   -3.8027    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0680   -4.2534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0385    0.5885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3202    0.9942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3124    1.8192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0230    2.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0153    3.0633    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    3.7413    1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7490    1.0076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  7 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
  6 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5018

>  <JC_XSMILES>
COC1=CC=C2C3CC(=NC4=CC=CC=C4N3C(=O)C2=C1OC)C5=CC=C(I)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.416

>  <W2 Pf proliferation inhibition EC50 uM>
0.2233

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.007246377

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5019
  Mrv1591402191617072D          

 37 42  0  0  0  0            999 V2000
    6.4938   -3.1948    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8053   -3.6493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8546   -4.4728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5925   -4.8418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3247   -4.4618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9125   -5.0408    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.5434   -5.7787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7276   -5.6557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0674   -3.2803    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4148   -3.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6133   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2665   -2.8408    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6355   -2.1029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -1.4898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2765   -1.6613    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7245   -1.0482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9175   -1.2198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3655   -0.6067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4415   -0.7782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9935   -0.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7386    0.6195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0684    0.7910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6204    0.1779    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3385   -0.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1454   -0.5337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6975   -1.1468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4425   -1.9314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0798   -2.4553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4004    0.2510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9154    0.9184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4004    1.5858    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1850    1.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    1.7434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6139    1.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6139    0.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    0.0934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1850    0.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  2  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 14 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 13 27  4  0  0  0  0
 27 28  1  0  0  0  0
  9 28  1  0  0  0  0
 25 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 29 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5019

>  <JC_XSMILES>
O=C(CC1=CSC=C1)N2CCOC3=C(OCCC4=CC=CC=N4)C=C(C=C3C2)C5=CSC6=CC=CC=C56

>  <PF proliferation inhibition 3D7 EC50 uM>
0.379

>  <W2 Pf proliferation inhibition EC50 uM>
0.2233

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.019417476

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5021
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    5.0013   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -8.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -8.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
  4 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5021

>  <JC_XSMILES>
ClC1=CC(=CC=C1OC2CCN(CC2)CC3CCCCC3)C(=O)NC4CC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1194

>  <W2 Pf proliferation inhibition EC50 uM>
0.0503

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
22.63

>  <Powder data?>
Yes

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5022
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -9.1474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -9.9320    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -9.1474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2460  -10.5995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5815  -11.3532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0966  -12.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2761  -11.9344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2088  -12.6018    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1268  -13.3555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9473  -13.4417    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3581  -14.0229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0226  -14.7766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5075  -15.4440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3280  -15.3578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6635  -14.6041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4840  -14.5179    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1786  -13.9367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8129  -16.0252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6334  -15.9390    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4774  -16.7789    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9623  -17.4463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6267  -18.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1116  -18.8675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9321  -18.7812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2677  -18.0275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7828  -17.3601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4170  -19.4487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1621  -20.2333    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8295  -20.7182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4970  -20.2333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2816  -20.4882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2420  -19.4487    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0594  -11.1807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4255  -10.5132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  2  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 17 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 27 30  1  0  0  0  0
 30 31  2  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
 30 35  1  0  0  0  0
 10 36  4  0  0  0  0
 36 37  4  0  0  0  0
  7 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5022

>  <JC_XSMILES>
CC1CN=C(N1)C2=CC=C(NC(=O)C3=CC=C(C(N)=C3)C(=O)NC4=CC=C(C=C4)C5=NCC(C)N5)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.047

>  <W2 Pf proliferation inhibition EC50 uM>
0.02222

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5023
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    4.5063    0.8732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0716    1.5745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2470    1.5487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8124    2.2499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    2.2242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5978    1.4972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0325    0.7959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8571    0.8217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2917    0.1205    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1163    0.1462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7732    1.4714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2406    0.8414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5232    1.1532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2244    0.7186    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4626    1.9760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0926    2.5086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9464    3.3206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8689    2.2293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3386    2.1727    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7286    2.8997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2940    3.6009    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6840    4.3279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2494    5.0291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5734    5.0897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7700    5.8909    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0688    6.3256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0082    7.1483    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.5613    5.7929    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5532    2.9254    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 15 19  1  0  0  0  0
 11 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 23 28  4  0  0  0  0
 20 29  2  0  0  0  0
  5 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5023

>  <JC_XSMILES>
COC1=CC2=C(C=C1OC)C3=NC(=O)C(C(C)C)N3C(SCC4=CSC(Cl)=N4)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.423

>  <W2 Pf proliferation inhibition EC50 uM>
0.03156

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.28

>  <Powder data?>
No

>  <IFI value>
0.036585366

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5024
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    2.9887   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4012   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2262   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7111   -1.2680    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0681    1.3646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7825    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7825    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0681   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7111   -2.6029    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
  6 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
  5 22  4  0  0  0  0
 22 23  4  0  0  0  0
  3 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5024

>  <JC_XSMILES>
CCC1=NN2C(NC3=CC=C4OCCOC4=C3)=CC(C)=NC2=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.36

>  <W2 Pf proliferation inhibition EC50 uM>
0.2191

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5027
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    5.8098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    6.5242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    6.5242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    5.8098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5027

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.926

>  <W2 Pf proliferation inhibition EC50 uM>
0.02163

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-503
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3289   -1.9230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9933   -1.1693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1728   -1.2555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 20 26  4  0  0  0  0
 18 27  4  0  0  0  0
  7 27  4  0  0  0  0
 27 28  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-503

>  <JC_XSMILES>
COCCNCC1=CC2=CC3=C(OCO3)C=C2N(CC4=CC=CC(F)=C4)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.273

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.054545455

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5031
  Mrv1591402191617072D          

 36 41  0  0  0  0            999 V2000
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -5.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3909   -6.0731    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429   -5.4600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6459   -6.8577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4528   -7.0293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7078   -7.8139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5147   -7.9854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0668   -7.3723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8118   -6.5877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0049   -6.4162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 14 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 13 29  4  0  0  0  0
 24 29  4  0  0  0  0
  3 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5031

>  <JC_XSMILES>
C1CN(CCC1N2CCC(CC2)N3C(CCC4=CC=CC=C4)=NC5=CC=CN=C35)CC6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1533

>  <W2 Pf proliferation inhibition EC50 uM>
0.1746

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
81.36

>  <Powder data?>
Yes

>  <IFI value>
0.019230769

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5032
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    5.8119   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975   -1.0709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -2.7209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -2.7209    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -0.2459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -0.2459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    0.9916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8060    0.8541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8060    0.3041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -0.2459    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    0.9916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975    1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975    2.2291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 10 26  4  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5032

>  <JC_XSMILES>
COC1=CC=C2N=CC=C(C(OC(C)=O)C3CC4CCN3CC4C=C)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2403

>  <W2 Pf proliferation inhibition EC50 uM>
0.2128

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.016260163

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5033
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    1.4401   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1546   -5.5690    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1546   -4.7440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8690   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5835   -5.5690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2980   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0125   -5.5690    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7269   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7269   -6.8065    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4414   -7.2190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1559   -6.8065    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1559   -5.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4414   -5.5690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6129   -4.7621    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4334   -4.6758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9183   -4.0084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7388   -4.0946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0744   -4.8483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8948   -4.9346    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.5894   -5.5158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7690   -5.4295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5033

>  <JC_XSMILES>
CN(C)CCCNC1=NC=NC2=C1NC3=CC=C(Cl)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02607

>  <W2 Pf proliferation inhibition EC50 uM>
0.0437

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.68

>  <Powder data?>
Yes

>  <IFI value>
0.117647059

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5035
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    0.7177   -7.4118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3822   -6.6581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4383   -6.5719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8671   -5.9907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -5.2370    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -4.5695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -3.7849    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -3.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -4.5695    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8810   -3.5300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0525   -2.7230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8372   -2.4681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4502   -3.0201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2787   -3.8271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4941   -4.0820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  8 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 20 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5035

>  <JC_XSMILES>
CC(C)COC1=NN(C(=N1)C2=CC=CC=C2)S(=O)(=O)C3=CC=CC4=CC=CN=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0423

>  <W2 Pf proliferation inhibition EC50 uM>
0.00456

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>2.16

>  <Powder data?>
No

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5036
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 11 10  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5036

>  <JC_XSMILES>
CC1=CC=C(C=C1)C(=O)NN=C(C)C2=CC=CC=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.35

>  <W2 Pf proliferation inhibition EC50 uM>
0.2087

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5037
  Mrv1591402191617072D          

 16 18  0  0  0  0            999 V2000
    0.7145   -2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
  5 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5037

>  <JC_XSMILES>
FC1=CC=C2NC3=CC=CC=C3C(=O)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1864

>  <W2 Pf proliferation inhibition EC50 uM>
0.2085

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5039
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
  4 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  2 22  4  0  0  0  0
 16 22  4  0  0  0  0
M  CHG  2  12   1  13  -1
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5039

>  <JC_XSMILES>
CC1=CC(NC2=CC=CC(=C2)[N+]([O-])=O)=NC3=CC(O)=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.672

>  <W2 Pf proliferation inhibition EC50 uM>
0.0751

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
36.3

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-504
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3022   -5.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4582   -5.0906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  2  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-504

>  <JC_XSMILES>
CCOC(=O)c1sc(=S)n(c1N)C2=CC=C(C=C2)N(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.192

>  <W2 Pf proliferation inhibition EC50 uM>
>1.273

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.015384615

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5047
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    0.9130   -0.8764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0171    0.3498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7621    1.1344    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0368   -2.7887    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8438   -2.9602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0987   -3.7449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5467   -4.3580    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7397   -4.1864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4848   -3.4018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8017   -5.1426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6086   -5.3141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8636   -6.0987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3115   -6.7118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5046   -6.5403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2496   -5.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  3  0  0  0  0
  3  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
  6 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5047

>  <JC_XSMILES>
CC1=C(C#N)C2=NC3=CC=CC=C3N2C(=C1)N4CCN(CC4)C5CCCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0635

>  <W2 Pf proliferation inhibition EC50 uM>
0.203

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.028776978

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5050
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    3.5439    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2584    1.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9728    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9728    2.3568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6873    2.7693    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6873    1.1193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4018    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1162    1.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1162    0.2943    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8307    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5452    1.1193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2989    1.4548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5538    2.2395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3608    2.4110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9128    1.7979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7198    1.9694    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.6579    1.0133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8509    0.8418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4384    0.1273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6933   -0.6573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1413   -1.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3962   -2.0551    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.3343   -1.0989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0794   -0.3143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6314    0.2988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  4  0  0  0  0
 19 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5050

>  <JC_XSMILES>
CCC(CO)NCC(O)CN1C2=CC=C(Cl)C=C2C3=CC(Cl)=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.368

>  <W2 Pf proliferation inhibition EC50 uM>
0.0406

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.1

>  <Powder data?>
Yes

>  <IFI value>
0.064516129

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5051
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    0.4210    3.7125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7780   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2629    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7780    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  1  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5051

>  <JC_XSMILES>
FC1=CC=C(CN2C3=C(CCC3)C(=N)C4=C2CCC4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2661

>  <W2 Pf proliferation inhibition EC50 uM>
0.2018

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5053
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  2 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 12 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5053

>  <JC_XSMILES>
OC(CNC1CCCCC1)CN2C3=CC=C(Cl)C=C3C4=CC(Cl)=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.333

>  <W2 Pf proliferation inhibition EC50 uM>
0.1155

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
57.31

>  <Powder data?>
Yes

>  <IFI value>
0.069767442

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5054
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    0.2498   -4.0609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6707    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2227    3.6495    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.9256    2.2518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  8 23  4  0  0  0  0
 19 23  4  0  0  0  0
M  CHG  1  10   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5054

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=C[N+](CC3=CC=C(Cl)C=C3)=C4CCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.373

>  <W2 Pf proliferation inhibition EC50 uM>
0.1526

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>75.72

>  <Powder data?>
Yes

>  <IFI value>
0.1

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5055
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -1.7065   -0.6783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2940    0.0362    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7065    0.7506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2940    1.4651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5489    2.2497    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8815    2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2140    2.2497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5706    2.5047    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1837    1.9526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7357    2.5657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6316    1.3395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7968    1.4006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5814    1.6555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3660    1.9105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3265    2.4402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8363    0.8709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4690    1.4651    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0565    0.7506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4690    0.0362    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8815    3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5959    3.9721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5959    4.7971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8815    5.2096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1670    4.7971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1670    3.9721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5475    3.5596    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2619    3.9721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2619    4.7971    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9764    3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6909    3.9721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4053    3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1198    3.9721    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5055

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)CCCCl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.753

>  <W2 Pf proliferation inhibition EC50 uM>
0.02015

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.046728972

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5057
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.8018   -4.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498   -4.0609    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076    1.3686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3444    0.7556    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473    2.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8543    2.3248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1092    3.1094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5572    3.7225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8121    4.5071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498    3.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
  9 26  4  0  0  0  0
 22 26  4  0  0  0  0
M  CHG  1  11   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5057

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C[N+](CC(=O)C3=CC=C(C)C=C3)=C4CCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.745

>  <W2 Pf proliferation inhibition EC50 uM>
0.2004

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5058
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  4  0  0  0  0
  9 26  4  0  0  0  0
 26 27  4  0  0  0  0
  6 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5058

>  <JC_XSMILES>
CCOC(=O)C1=CC=C(NC2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.482

>  <W2 Pf proliferation inhibition EC50 uM>
0.2002

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5059
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0339   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8186   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9901   -2.4922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7747   -2.2373    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3770   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5924   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8810   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0525   -1.8980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8372   -1.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0087   -0.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7933   -0.5812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4064   -1.1332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2349   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4502   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4941   -3.2570    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3226   -4.0640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5379   -4.3189    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9357   -4.6160    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7641   -5.4230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9572   -5.2515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5711   -5.5945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5926   -6.2300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
  9 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  8 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 22 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 34 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5059

>  <JC_XSMILES>
CC1=CC=C(C=C1)N2C(SCC3=CC=C(F)C=C3)=NN=C2C(CC4=CC=CC=C4)NC(=O)NC(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.33

>  <W2 Pf proliferation inhibition EC50 uM>
0.1246

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>62.31

>  <Powder data?>
Yes

>  <IFI value>
0.032608696

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5060
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2243   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
  3 17  4  0  0  0  0
 10 17  4  0  0  0  0
M  CHG  1  10   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5060

>  <JC_XSMILES>
CCN1C2=CC=CC=C2[N+]3=C(C)C=C(C)N=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2664

>  <W2 Pf proliferation inhibition EC50 uM>
0.1994

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5064
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9909    3.6664    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659    4.4914    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659    2.8414    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 32 35  1  0  0  0  0
 35 36  1  0  0  0  0
 35 37  1  0  0  0  0
 35 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5064

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4=CC=C(C=C4)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.847

>  <W2 Pf proliferation inhibition EC50 uM>
0.01992

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.070175439

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5065
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -3.0516   -1.1549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0228   -0.3304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2944    0.0569    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2656    0.8814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9652    1.3186    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371    1.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752    0.3126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2822    0.4841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0451    1.9188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7360    2.6837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2439    3.3338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9349    4.0988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1179    4.2136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8089    4.9785    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3168    5.6286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6100    3.5635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9190    2.7986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
  6 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  4  0  0  0  0
 24 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5065

>  <JC_XSMILES>
CCOC(=O)C1(CCN(CC1)C(=O)C2=C3OCCOC3=CS2)CC4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2637

>  <W2 Pf proliferation inhibition EC50 uM>
0.1989

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5066
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5700    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
  5 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 14 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 13 29  1  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5066

>  <JC_XSMILES>
CC(=O)N(C1=CC=C(F)C(F)=C1)C2=C(N3CCCCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2377

>  <W2 Pf proliferation inhibition EC50 uM>
0.0947

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
47.67

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5069
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
    1.4461    6.8949    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9982    6.2818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7432    5.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9362    5.3256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2953    4.8841    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0403    4.0994    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5923    3.4863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3993    3.6579    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6543    4.4425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1022    5.0556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4793    4.4425    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7342    3.6579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5188    3.4029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1319    3.9550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9165    3.7000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0881    2.8930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4750    2.3410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6903    2.5960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
 12 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5069

>  <JC_XSMILES>
NCC(=O)N1CCN2C(C1)=NC(=C2NC3=CC=C4OCOC4=C3)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1615

>  <W2 Pf proliferation inhibition EC50 uM>
0.1982

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-507
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  5 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 26 32  4  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-507

>  <JC_XSMILES>
CCC(C)N(CCC(=O)N1CCN(CC1)CC2=CC=CC=C2)C(=O)NC3=CC=CC(Cl)=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.563

>  <W2 Pf proliferation inhibition EC50 uM>
>1.062

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.39

>  <Powder data?>
No

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5071
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -9.1474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -9.1474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
  4 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 28 31  1  0  0  0  0
 31 32  2  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 31 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5071

>  <JC_XSMILES>
NC1=CC(=CC=C1C(=O)NC2=CC=C(C=C2)C3=NCCN3)C(=O)NC4=CC=C(C=C4)C5=NCCN5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2903

>  <W2 Pf proliferation inhibition EC50 uM>
0.1792

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
90.57

>  <Powder data?>
Yes

>  <IFI value>
0.025862069

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5074
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5074

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Br)C=C3)C(=O)CC(C2)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.498

>  <W2 Pf proliferation inhibition EC50 uM>
0.1976

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5078
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    5.6370   -6.5971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -5.7721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -5.3596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -5.7721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -4.5346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -4.1221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -3.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -2.8846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -3.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -4.1221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -2.0596    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -1.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -0.8221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -0.4096    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935   -0.4096    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935    0.4154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791    0.8279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791    1.6529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935    2.0654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080    1.6529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080    0.8279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935   -2.0596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935   -2.8846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791   -3.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0646   -2.8846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0646   -2.0596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791   -1.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791   -0.8221    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -1.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3514   -2.0596    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -0.8221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3514   -0.4096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4377    0.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2446    0.5824    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6571   -0.1320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4641   -0.3036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7190   -1.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1670   -1.7013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3600   -1.5298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1051   -0.7451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 11 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 32 40  4  0  0  0  0
 35 40  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  34
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5078

>  <JC_XSMILES>
COC(=O)C1=CC=C(C=C1)N(C(C(=O)NC2CCCCC2)C3=CC=CC=C3F)C(=O)CC4=CNC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2002

>  <W2 Pf proliferation inhibition EC50 uM>
0.1967

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.054545455

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5079
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  3  0  0  0  0
  4  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 21 22  1  0  0  0  0
 10 23  4  0  0  0  0
  3 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5079

>  <JC_XSMILES>
CCC1=C(C#N)C(N)=NC(SCC(=O)C2=CC=C(C)C=C2C)=C1C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3082

>  <W2 Pf proliferation inhibition EC50 uM>
0.1961

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5084
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    8.6143    8.0345    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.2787    7.2808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7636    6.6134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4281    5.8597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6076    5.7734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2720    5.0198    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4516    4.9335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1160    4.1799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6009    3.5124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2955    4.0936    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9600    3.3400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3725    2.6255    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8204    2.0124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1530    3.1684    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1227    6.4409    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4582    7.1946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5084

>  <JC_XSMILES>
ClC1=CC=C(OCC(=O)NC2=NN=C(S2)C3=CC=C4OCOC4=C3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>13.77

>  <Powder data?>
No

>  <IFI value>
0.017094017

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5085
  Mrv1591402191617072D          

 48 55  0  0  0  0            999 V2000
   -0.8328    2.0582    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7736    1.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4567    0.7727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3975   -0.0502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6553   -0.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0277    0.0523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6514   -0.4877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7357    0.6202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3315    1.5580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9552    1.0180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0143    0.1951    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4743   -0.4286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7972   -0.0651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4140    0.4827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1969    0.2225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3630   -0.5856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7462   -1.1335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9633   -0.8732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3465   -1.4211    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5125   -2.2292    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206   -2.0632    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6786   -3.0373    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7044   -2.3953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1565   -1.7785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3484   -1.9445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0882   -2.7274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7199   -2.8935    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9802   -3.6763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4323   -4.2932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3758   -4.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6361   -3.3442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4442   -3.1782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1459   -0.8459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3119   -1.6540    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7627   -0.2980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5966    0.5101    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2134    1.0580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9963    0.7978    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1624   -0.0104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5455   -0.5582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6131    1.3456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4471    2.1537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0639    2.7016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8468    2.4414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0128    1.6333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3960    1.0854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5086    1.4989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0314    0.8752    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  4  0  0  0  0
 31 32  4  0  0  0  0
 23 32  4  0  0  0  0
 16 33  1  0  0  0  0
 33 34  2  0  0  0  0
 33 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 35 40  1  0  0  0  0
 38 41  1  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 41 46  4  0  0  0  0
  9 47  1  0  0  0  0
 47 48  1  0  0  0  0
  2 48  4  0  0  0  0
  6 48  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5085

>  <JC_XSMILES>
O=C1C=CC=C2C3CC(CN(C3)C4=CC=C(C=C4NS(=O)(=O)C5=CC=C6OCCOC6=C5)C(=O)N7CCN(CC7)C8=CC=CC=N8)CN12

>  <PF proliferation inhibition 3D7 EC50 uM>
2.018

>  <W2 Pf proliferation inhibition EC50 uM>
0.1941

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5087
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
   -5.3745    4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6600    3.9464    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9455    4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9455    5.1839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2311    5.5964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5166    5.1839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8021    5.5964    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0877    5.1839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5166    4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2311    3.9464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8021    3.9464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0877    4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3732    3.9464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3732    3.1214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3413    2.7089    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0877    2.7089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0877    1.8839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3732    1.4714    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3732    0.6464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4540    0.2037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4540   -0.6213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0558   -1.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7702   -0.5911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7702    0.2339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0558    0.6464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8495   -0.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1350   -0.5911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1350    0.2339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8021    3.1214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 25 26  1  0  0  0  0
 22 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 26 28  1  0  0  0  0
 16 29  4  0  0  0  0
 11 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5087

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CNCC3CC4C=CC3C45CC5)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.35

>  <W2 Pf proliferation inhibition EC50 uM>
0.0398

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.61

>  <Powder data?>
Yes

>  <IFI value>
0.017094017

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5088
  Mrv1591402191617072D          

 16 18  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  5 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 16  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5088

>  <JC_XSMILES>
ClC1=CC=C2C(=C1)N=CC=C2N3CCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2833

>  <W2 Pf proliferation inhibition EC50 uM>
0.1243

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
64.54

>  <Powder data?>
Yes

>  <IFI value>
0.057142857

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5090
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    3.8673   -2.5381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0751   -2.3078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8784   -1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1147   -1.1947    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1752   -0.3719    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5452    0.1607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7689   -0.1186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1389    0.4140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2851    1.2259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0614    1.5052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6914    0.9726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9765   -0.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3664    0.5517    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1910    0.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5810    1.3045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1464    2.0057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5364    2.7327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1018    3.4340    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.3610    2.7585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7956    2.0573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4056    1.3302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8402    0.6290    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6256   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4502   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8849   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7095   -0.7735    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0994   -0.0465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4949   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9295   -2.2275    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5395   -2.9545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6703   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2357   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4111   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  5 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 21 22  1  0  0  0  0
 14 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  4  0  0  0  0
 23 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
 12 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5090

>  <JC_XSMILES>
CCC1=NN(C2=CC=CC=C2)C3=NC(C4=CC(Br)=CC=C4O)=C5C=C(OC)C(OC)=CC5=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.466

>  <W2 Pf proliferation inhibition EC50 uM>
0.192

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5091
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 16 22  1  0  0  0  0
 19 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  1  0  0  0  0
 11 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5091

>  <JC_XSMILES>
CC(C)OC(=O)C1=C(C)N=C(N=C1C(=O)N2CCN(C(C)C2)C(=O)NC3=CC=CC=C3C)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.135

>  <W2 Pf proliferation inhibition EC50 uM>
0.0995

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
51.86

>  <Powder data?>
Yes

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5093
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
    4.0865   -8.2397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4990   -7.5252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0865   -6.8107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4990   -6.0963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0865   -5.3818    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4990   -4.6673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3240   -4.6673    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0865   -3.9529    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4990   -3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0865   -2.5239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2615   -2.5239    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490   -3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2615   -3.9529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490   -4.6673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490   -1.8094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0240   -1.8094    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2615   -1.0950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0240   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7545   -0.7930    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7545    0.0320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1414    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3129    1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0975    1.6459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7106    1.0939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391    0.2869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0865   -1.0950    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4990   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0865    0.3340    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3240   -0.3805    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7365    0.3340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3240    1.0484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7365    1.7629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5615    1.7629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9740    1.0484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5615    0.3340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7990    1.0484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6240    1.0484    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 13 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 19 27  4  0  0  0  0
 22 27  4  0  0  0  0
 17 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 36 38  1  0  0  0  0
 38 39  3  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5093

>  <JC_XSMILES>
CCCCNC(=O)N1CCN(CC1C)C(=O)C(CC2=CNC3=CC=CC=C23)NC(=O)NC4=CC=CC(=C4)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1535

>  <W2 Pf proliferation inhibition EC50 uM>
0.1906

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5097
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 16 29  4  0  0  0  0
 11 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5097

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CN(C)CC(O)C3=CC=CC=C3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2427

>  <W2 Pf proliferation inhibition EC50 uM>
0.1244

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
66.34

>  <Powder data?>
Yes

>  <IFI value>
0.00990099

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5098
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
   -3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -2.5855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
  5 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 33 34  4  0  0  0  0
  3 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5098

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=C(F)C=C2)C(=O)C(C)(C)CCl)=C3N=CC=CC3=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.469

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00343

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>1.831

>  <Powder data?>
No

>  <IFI value>
0.010526316

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5099
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
   13.2589   -5.1800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5444   -4.7675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.8300   -5.1800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8300   -6.0050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1155   -6.4175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4010   -6.0050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6164   -6.2600    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1315   -5.5925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3065   -5.5925    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.8940   -4.8781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0690   -4.8781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6565   -5.5925    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6565   -4.1636    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8315   -4.1636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4190   -4.8781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5940   -4.8781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1815   -4.1636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5940   -3.4491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1815   -2.7346    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3565   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9440   -3.4491    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9440   -2.0202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190   -2.0202    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065   -1.3057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8860   -1.2195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0420   -0.5520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4190   -3.4491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.6164   -4.9251    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4010   -5.1800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1155   -4.7675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 26 33  4  0  0  0  0
 33 34  4  0  0  0  0
 24 34  4  0  0  0  0
 18 35  4  0  0  0  0
 14 35  4  0  0  0  0
  8 36  4  0  0  0  0
 36 37  4  0  0  0  0
  6 37  4  0  0  0  0
 37 38  4  0  0  0  0
  3 38  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1   7
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  34
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5099

>  <JC_XSMILES>
COC1=CC=C2NC(SCC(=O)NC3=CC=CC(NC(=O)CSC4=NC5=CC(OC)=CC=C5N4)=N3)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1232

>  <W2 Pf proliferation inhibition EC50 uM>
0.0954

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>50.95

>  <Powder data?>
Yes

>  <IFI value>
0.130952381

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-510
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    2.6733   -6.1220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1213   -5.5089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3762   -4.7243    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8913   -4.0569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663   -4.0569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -4.7714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663   -5.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -6.2003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9894   -6.9540    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7963   -7.1255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3763   -7.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3763   -8.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3382   -8.7435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0527   -8.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0527   -7.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3382   -7.0935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1667   -6.2865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9486   -6.0234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2572   -5.4665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3762   -3.3894    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1213   -2.6048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3143   -2.4333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0594   -1.6487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6114   -1.0356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4184   -1.2071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6733   -1.9917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1608   -3.6444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8753   -3.2319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5898   -3.6444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5898   -4.4694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8753   -4.8819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1608   -4.4694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
  4 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 20 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
  3 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  CHG  1  20   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-510

>  <JC_XSMILES>
CCN1C(=C/C=C/C2=[N+](C)C3=CC=CC=C3C2(C)C)\N(C4=CC=CC=C4)C5=CC=CC=C15

>  <PF proliferation inhibition 3D7 EC50 uM>
1.405

>  <W2 Pf proliferation inhibition EC50 uM>
1.263

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.285714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5100
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 29 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5100

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.654

>  <W2 Pf proliferation inhibition EC50 uM>
0.01871

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5101
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -4.7051    0.7485    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7667   -0.0742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9440   -0.1358    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5894   -0.0125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8284   -0.8969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5717   -1.2548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6333   -2.0775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9517   -2.5423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2084   -2.1843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1467   -1.3616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4034   -1.0037    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7218   -1.4684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7834   -2.2911    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9785   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9785   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3335    0.2289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5292    0.0454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5292   -1.4412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3335   -1.6248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 14 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
 29 30  4  0  0  0  0
 21 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5101

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC=C1NC(=S)N2CCCN(CC2)C3=NC4=CC=C(Cl)C=C4S3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1194

>  <W2 Pf proliferation inhibition EC50 uM>
0.1455

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
77.81

>  <Powder data?>
Yes

>  <IFI value>
0.061946903

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5103
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  4  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 11 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  3 16  4  0  0  0  0
  9 16  4  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5103

>  <JC_XSMILES>
CC[N+]1=C(SC)C=CC2=CC(OC)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0924

>  <W2 Pf proliferation inhibition EC50 uM>
0.1863

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.079365079

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5104
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    5.8098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    5.8098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5104

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)CCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.853

>  <W2 Pf proliferation inhibition EC50 uM>
0.01861

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-511
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -1.2731   -4.1850    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4913   -3.9214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2278   -4.7032    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7549   -3.1396    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.2904   -3.6578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4530   -2.8490    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2348   -2.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8540   -3.1307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6357   -2.8671    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2549   -3.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0743   -3.3171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5519   -2.6443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3733   -2.7215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7171   -3.4714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2396   -4.1442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4182   -4.0670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8112   -4.6258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9065   -5.4452    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0922   -4.2212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3105   -4.4847    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6913   -3.9395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9096   -4.2031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 10 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  8 21  4  0  0  0  0
 21 22  4  0  0  0  0
  5 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-511

>  <JC_XSMILES>
FC(F)(F)C1=CC=C2N=C3C4=CC=CC=C4C(=O)C3=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.139

>  <W2 Pf proliferation inhibition EC50 uM>
1.263

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5112
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -3.6020    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -2.1730    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  6 13  4  0  0  0  0
  2 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  3  0  0  0  0
  4 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5112

>  <JC_XSMILES>
NC1=NC(=NC(C2=CC=CC=C2)=C1C#N)C(Cl)(Cl)Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.498

>  <W2 Pf proliferation inhibition EC50 uM>
0.184

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.014705882

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5115
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -0.8250   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -0.9355    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.2211    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8875   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7080   -2.4507    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8795   -3.2577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1650   -3.6702    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5519   -3.1181    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6332   -3.5932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3006   -3.1083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0543   -3.4439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1405   -4.2644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4731   -4.7493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7194   -4.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8942   -4.5999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9804   -5.4204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5616   -4.1150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    1.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    1.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  3 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5115

>  <JC_XSMILES>
CCN(C(=O)CSC1=NC(=NO1)C2=CC=C(C=C2)C(C)C)C3=CC=CC(C)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.356

>  <W2 Pf proliferation inhibition EC50 uM>
0.1832

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5117
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.9962   -4.9848    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -3.8578    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1232   -4.6828    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
 10  9  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
  9 22  4  0  0  0  0
  5 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5117

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(C=NNC2=NC3=CC=CC=C3N2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0946

>  <W2 Pf proliferation inhibition EC50 uM>
0.1154

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
63.2

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5119
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 24 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5119

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=C(Br)C=C3)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.45

>  <W2 Pf proliferation inhibition EC50 uM>
0.1812

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.048780488

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5121
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0681   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7825   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7825   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4970   -2.7604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.2115   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0681   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9966   -3.8404    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5117   -3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9966   -2.5055    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  2  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  6 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 22 26  4  0  0  0  0
 26 27  4  0  0  0  0
 19 27  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5121

>  <JC_XSMILES>
CCOC(=O)C1=C(O)C2=CC=C(OC)C=C2N=C1C3=CC=C4OCOC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.127

>  <W2 Pf proliferation inhibition EC50 uM>
0.1797

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5124
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
  5 14  4  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5124

>  <JC_XSMILES>
CC(C)(C)C1=CC=C2OCN(CC2=C1)C3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.099

>  <W2 Pf proliferation inhibition EC50 uM>
0.0369

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.75

>  <Powder data?>
Yes

>  <IFI value>
0.018181818

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5126
  Mrv1591402191617072D          

 27 31  0  0  0  0            999 V2000
    1.3416    5.2524    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5106    4.4449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2944    4.1874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4633    3.3799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2472    3.1225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4161    2.3150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8013    1.7649    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0175    2.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8485    2.8298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9703    0.9574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7541    0.7000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4698    1.1102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0812    0.5562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7432   -0.1964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9230   -0.1075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3082   -0.6576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4772   -1.4651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6461   -2.2727    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5244   -0.4002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8086   -0.8104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1973   -0.2565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3765   -0.3401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1063    0.3289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2317    1.0815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0524    1.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5352    0.4961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3554    0.4073    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  3  0  0  0  0
 16 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 10 27  4  0  0  0  0
 19 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5126

>  <JC_XSMILES>
OCCN1CCN(CC1)C2=C3CCCC3=C(C#N)C4=NC5=CC=CC=C5N24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2069

>  <W2 Pf proliferation inhibition EC50 uM>
0.1766

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023255814

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5127
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    3.3396   -4.3667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6251   -4.7792    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6251   -5.6042    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9106   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1962   -5.6042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3396   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3396   -6.8417    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0540   -5.6042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685   -6.0167    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.4830   -5.6042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5692   -4.7837    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3762   -4.6122    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7887   -5.3267    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2367   -5.9398    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4082   -6.7467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1928   -7.0017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3643   -7.8087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7512   -8.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9228   -9.1677    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7074   -9.4226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9666   -8.1057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7951   -7.2988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6092   -5.4129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0941   -4.7455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9146   -4.8317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2501   -5.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7652   -6.2528    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9447   -6.1666    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 21 22  4  0  0  0  0
 15 22  4  0  0  0  0
 13 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5127

>  <JC_XSMILES>
CCN(CC)C(=O)CSC1=NN=C(N1C2=CC=C(OC)C=C2)C3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.287

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00558

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.19

>  <Powder data?>
No

>  <IFI value>
0.036363636

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5129
  Mrv1591402191617072D          

 27 31  0  0  0  0            999 V2000
    4.2243    5.1501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0080    4.8923    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1766    4.0847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9603    3.8269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1289    3.0193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5138    2.4695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7301    2.7273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5615    3.5349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6824    1.6619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4832    1.4634    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.8273    0.7136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6509    0.7600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1029    0.0698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7312   -0.6667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9076   -0.7131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4556   -0.0229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6480   -0.1915    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0126    0.3348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2234    0.0944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8739   -0.6529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0520   -0.7239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5795   -0.0475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9290    0.6998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7510    0.7708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2482    1.4291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0079    2.2183    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0279    1.1596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
  9 27  1  0  0  0  0
 18 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5129

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2SC3=CC=CC=C3N=C4C5=CC=CC=C5C(O)=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2383

>  <W2 Pf proliferation inhibition EC50 uM>
0.1745

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5131
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
    3.0919   -4.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
  8 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
  7 34  4  0  0  0  0
 29 34  4  0  0  0  0
  5 35  4  0  0  0  0
 35 36  4  0  0  0  0
  2 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5131

>  <JC_XSMILES>
CC1=CC=C(CN2C(SCC3=CC=C(C=C3)C(=O)NCCC4=CC=CC=C4)=NC5=CC=NC=C25)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.7

>  <W2 Pf proliferation inhibition EC50 uM>
0.1735

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5132
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 16 22  1  0  0  0  0
 14 23  4  0  0  0  0
  9 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5132

>  <JC_XSMILES>
COC1=CC=CC(=N1)C2=CC=C(O)C(CN3CCC(C)CC3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.337

>  <W2 Pf proliferation inhibition EC50 uM>
0.1293

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
74.95

>  <Powder data?>
Yes

>  <IFI value>
0.017391304

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5135
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0123    0.2416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.3417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1640   -0.7163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7895   -1.4513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0444   -2.2360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8514   -2.4075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0544   -1.0768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2396   -0.9477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105   -0.1329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8456    0.2416    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 11 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 24 27  1  0  0  0  0
 22 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 20 30  1  0  0  0  0
 22 30  1  0  0  0  0
 10 31  4  0  0  0  0
  6 31  4  0  0  0  0
 31 32  4  0  0  0  0
  3 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5135

>  <JC_XSMILES>
COC1=CC=C2N=CC=C(C(OC(=O)CCC(O)=O)C3CC45CC(C=C)C4CCN35)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01402

>  <W2 Pf proliferation inhibition EC50 uM>
0.0775

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
45.67

>  <Powder data?>
Yes

>  <IFI value>
0.054545455

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5138
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
    0.5597   -2.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9943   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6043   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0390   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6490    0.6290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8636   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2982    0.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9082    1.3045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0836    1.3302    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3428    2.0057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9528    2.7327    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3874    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0755    4.1978    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7056    4.7304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7313    5.5550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4583    5.9450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1596    5.5104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1338    4.6858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4068    4.2958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2102    3.4945    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.1228    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0049    1.3683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9064    0.8095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -0.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0781   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6108   -1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4141   -2.3078    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3745   -1.1947    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3140   -0.3719    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2535   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8189   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
  7 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  2  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 25 30  1  0  0  0  0
  6 30  4  0  0  0  0
 30 31  4  0  0  0  0
  2 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5138

>  <JC_XSMILES>
CC1=CC(C)=C2N(C(=O)COC3=NC4=CC=CC=C4S3)C(C)(C)C5=C(C(=S)SS5)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1251

>  <W2 Pf proliferation inhibition EC50 uM>
0.1692

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5139
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.1460    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.1460    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 21 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
 23 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5139

>  <JC_XSMILES>
COC1=CC=CC=C1NC(=O)N2CCN(CC2C)C(=O)C3=NC(=NC(C)=C3C(=O)OC(C)C)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.529

>  <W2 Pf proliferation inhibition EC50 uM>
<0.0169

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009433962

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5141
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.0694    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1544   -0.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9614   -0.8867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2163   -1.6713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2243    1.9817    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
  7 21  4  0  0  0  0
 11 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5141

>  <JC_XSMILES>
CCCN1CCC2=C(C1)SC3=NC(SCC=C)=NC(N)=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.623

>  <W2 Pf proliferation inhibition EC50 uM>
0.1677

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.14

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5142
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9441   -0.0045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7511    0.1670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1636   -0.5475    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6116   -1.1606    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7831   -1.9675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5677   -2.2225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7392   -3.0294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1261   -3.5815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3415   -3.3265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1700   -2.5196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0866    0.9207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4222    1.6744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8403    0.5851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3330    1.2562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  5 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 27 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5142

>  <JC_XSMILES>
CC(C)CN(CC(=O)NC1=CC(=NN1C2=CC=CC=C2)C(C)(C)C)C(=O)C3=CC(Cl)=CC(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.229

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01667

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5143
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 12 21  4  0  0  0  0
 11 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 25  1  0  0  0  0
 22 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 10 31  1  0  0  0  0
  6 31  2  0  0  0  0
 31 32  1  0  0  0  0
  7 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 37 40  4  0  0  0  0
 33 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5143

>  <JC_XSMILES>
CCOC(=O)C1C(CC2=C(C(C3=CC=C(OC)C(OC)=C3)C(=C(C)N2)C(=O)OCC)C1=O)C4=CC=CC(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.376

>  <W2 Pf proliferation inhibition EC50 uM>
0.1667

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034883721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5147
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
  9 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
M  CHG  2  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5147

>  <JC_XSMILES>
COC(=O)C1=CNC=C(C1C2=CC=C(Cl)C(=C2)[N+]([O-])=O)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1352

>  <W2 Pf proliferation inhibition EC50 uM>
0.1652

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5152
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  2 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5152

>  <JC_XSMILES>
OC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)CN3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.881

>  <W2 Pf proliferation inhibition EC50 uM>
0.144

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
87.89

>  <Powder data?>
Yes

>  <IFI value>
0.01459854

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5155
  Mrv1591402191617072D          

 21 21  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  3 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  2  0  0  0  0
  2 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5155

>  <JC_XSMILES>
CC(N(CC1=CC=CC=C1)S(C)(=O)=O)C(=O)NCCCN

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.0162

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.039215686

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-516
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3260   -1.7269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8781   -2.3400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4656   -3.0545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6586   -2.8830    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  2 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-516

>  <JC_XSMILES>
O=C(COC1=CC=CC=C1)NC2=NC=CS2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.258

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.074766355

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5160
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 17 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
  5 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5160

>  <JC_XSMILES>
COC1=CC(=CC=C1OC2CCN(CC2)CC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)NCC#C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2071

>  <W2 Pf proliferation inhibition EC50 uM>
0.0883

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
55.04

>  <Powder data?>
Yes

>  <IFI value>
0.02739726

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5163
  Mrv1591402191617072D          

 33 35  0  0  1  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4647   -4.0640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0778   -4.6160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8624   -4.3611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0339   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4755   -4.9131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0886   -5.4651    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9235   -5.5262    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0275   -4.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -4.3257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4824   -3.5721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6318   -4.9932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4522   -4.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9372   -5.5744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6016   -6.3281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0865   -6.9955    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9070   -6.9093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7811   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2962   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4757   -5.8331    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9908   -5.1657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  5  3  1  6  0  0  0
  5  6  1  0  0  0  0
  7  6  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
  7 21  1  1  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  4  0  0  0  0
 24 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5163

>  <JC_XSMILES>
COC(=O)[C@@H]1C[C@H](CN1CC2=CC=C(C=C2)C(F)(F)F)NC(=O)C3=CC=C(OC)C=C3OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.347

>  <W2 Pf proliferation inhibition EC50 uM>
0.159

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034782609

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5164
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
   -1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007   -1.2330    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6077   -1.4045    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0202   -0.6900    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4681   -0.0769    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6397    0.7300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4243    0.9850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0374    0.4329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8220    0.6879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9935    1.4948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3804    2.0469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5958    1.7919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 13 26  4  0  0  0  0
 26 27  2  0  0  0  0
 12 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 28 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  25
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5164

>  <JC_XSMILES>
CCOC(=O)C1CCN(CC1)C(C2=CC3=CC(OC)=C(OC)C=C3NC2=O)C4=NN=NN4CC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.419

>  <W2 Pf proliferation inhibition EC50 uM>
0.158

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.010309278

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5166
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  8 21  4  0  0  0  0
 21 22  2  0  0  0  0
  6 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5166

>  <JC_XSMILES>
CN(C)CCN(CC1=CC2=CC3=C(OCCO3)C=C2NC1=O)C(=O)NC4=CC=C(C)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.984

>  <W2 Pf proliferation inhibition EC50 uM>
0.1571

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.063492063

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5168
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   19.2907   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 16 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5168

>  <JC_XSMILES>
CCOC(=O)CCC(=O)N(C)CCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.673

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01562

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.027522936

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-517
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -1.4604    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2784   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5159   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5159    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 12 22  1  0  0  0  0
  8 22  1  0  0  0  0
  6 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 26 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-517

>  <JC_XSMILES>
COC(=O)C1=C(SC2=C1CCN(CCCC3=CC=CC=C3)C2)S(=O)(=O)N4CCN(C)CC4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.421

>  <W2 Pf proliferation inhibition EC50 uM>
1.257

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019607843

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5170
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    0.7145    0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6039   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.2539   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
  8 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 15 23  4  0  0  0  0
  5 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5170

>  <JC_XSMILES>
FC(F)(F)C1=CC=C(N2CCOCC2)C(NC(=O)C(Cl)(Cl)Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.376

>  <W2 Pf proliferation inhibition EC50 uM>
0.1163

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
74.79

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5171
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 23 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5171

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC=C(C=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.326

>  <W2 Pf proliferation inhibition EC50 uM>
<0.0156

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.05

>  <Powder data?>
No

>  <IFI value>
0.028301887

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5172
  Mrv1591402191617072D          

 44 50  0  0  0  0            999 V2000
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -0.5422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -0.3707    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -1.9399    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5534   -1.8537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8889   -2.6074    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2759   -3.1594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3621   -3.9799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1158   -4.3154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2020   -5.1359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5346   -5.6208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7809   -5.2853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6946   -4.4648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5614   -2.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8077   -3.0825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7215   -3.9029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0322   -4.2385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6996   -3.7536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6134   -2.9331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1403   -2.5975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    3.1465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    3.9312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    4.5442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    4.3727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  4  0  0  0  0
 12 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
  7 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 29 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
 36 43  4  0  0  0  0
  6 43  4  0  0  0  0
 43 44  4  0  0  0  0
  2 44  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5172

>  <JC_XSMILES>
CC1=CC(C)=C2N(CC(O)CN3C=NC(C4=CC=CC=C4)=C3C5=CC=CC=C5)C(C6=CC=CC=C6)=C(C7=CC=CC=C7)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.35

>  <W2 Pf proliferation inhibition EC50 uM>
0.1551

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022988506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5175
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 16 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 26 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 23 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5175

>  <JC_XSMILES>
CCOC1=CC(=CC=C1O)C2CC(=O)NC3=C2C(=O)CC(C3)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.781

>  <W2 Pf proliferation inhibition EC50 uM>
0.1548

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5176
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  6 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  5 22  4  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5176

>  <JC_XSMILES>
CC(=O)NC1=C(NCC2=CC=CC=C2)C3=CC=CC=C3SC1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.505

>  <W2 Pf proliferation inhibition EC50 uM>
0.1545

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.02173913

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5178
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -1.5356    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    5.5902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    4.3527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    3.1152    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186    1.8053    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637    1.0206    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387    1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837    1.8053    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8538    0.3532    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1087   -0.4314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4413   -0.9163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7738   -0.4314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0288    0.3532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5438    1.0206    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 22 26  1  0  0  0  0
 26 27  2  0  0  0  0
  7 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5178

>  <JC_XSMILES>
CC1=CC=C(C)C(NC(=O)C2CCCN(C2)C3=NN=C(S3)N4CCCC4=O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>5.75

>  <W2 Pf proliferation inhibition EC50 uM>
0.1543

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5179
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    1.1490    8.2926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7011    7.6795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5080    7.8510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4461    6.8949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9982    6.2818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8051    6.4533    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7432    5.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9362    5.3256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2953    4.8841    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0403    4.0994    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5923    3.4863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3993    3.6579    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6543    4.4425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1022    5.0556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4793    4.4425    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7342    3.6579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5188    3.4029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1319    3.9550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9165    3.7000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0881    2.8930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4750    2.3410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6903    2.5960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 16 23  4  0  0  0  0
 12 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 28 32  4  0  0  0  0
 32 33  4  0  0  0  0
 25 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5179

>  <JC_XSMILES>
CC(C)CC(N)C(=O)N1CCN2C(C1)=NC(C3=CC=CC=C3)=C2NC4=CC=C5OCOC5=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1191

>  <W2 Pf proliferation inhibition EC50 uM>
0.1224

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>79.53

>  <Powder data?>
Yes

>  <IFI value>
0.04109589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-518
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 12 22  1  0  0  0  0
M  CHG  1   5   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-518

>  <JC_XSMILES>
CCCCN1C=CC=C\C1=C/C2=[N+](CC)C3=CC=CC=C3S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1204

>  <W2 Pf proliferation inhibition EC50 uM>
0.2261

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.799

>  <Powder data?>
Yes

>  <IFI value>
0.181818182

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5180
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5253   -5.4349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -6.2195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9605   -6.8870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1904   -5.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7553   -6.8870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5758   -6.8007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0607   -7.4682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8812   -7.3820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3661   -8.0494    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1866   -7.9632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6715   -8.6306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4920   -8.5444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9769   -9.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7974   -9.1256    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    8.6414   -9.9655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8209  -10.0517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3360   -9.3843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5155   -9.4705    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -8.2219    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9047   -8.3081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5691   -9.0618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4197   -7.6407    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  2  7  4  0  0  0  0
  4  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 10 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
  8 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5180

>  <JC_XSMILES>
CC1=NN(C(C)=C1)C2=CC(NN=CC3=CC(Br)=CC=C3O)=NC(C)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2366

>  <W2 Pf proliferation inhibition EC50 uM>
0.1535

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5182
  Mrv1591402191617072D          

 21 21  0  0  0  0            999 V2000
    1.7309   -4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809   -4.4270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809   -2.9980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2059   -2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -2.2836    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4434   -2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8559   -1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6809   -1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0934   -2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6809   -2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8559   -2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9184   -2.2836    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    8.3309   -1.5691    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    8.3309   -2.9980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9039   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0309   -4.4270    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
  7 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
M  CHG  2  15   1  16  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5182

>  <JC_XSMILES>
CC(C)C(=O)NC(NC1=CC=C(C=C1)[N+]([O-])=O)C(Cl)(Cl)Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1951

>  <W2 Pf proliferation inhibition EC50 uM>
0.1042

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
68.26

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5183
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164   -3.4105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -4.8395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
  6 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5183

>  <JC_XSMILES>
CC1=CC(Cl)=C(C=C1OCC(=O)NC2CCCCC2)S(=O)(=O)N3CCSCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.186

>  <W2 Pf proliferation inhibition EC50 uM>
0.1526

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5185
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    3.1612   -4.9580    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.4468   -4.5455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0343   -5.2600    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8593   -3.8311    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7323   -4.1330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7323   -3.3080    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0178   -2.8955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3034   -3.3080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3034   -4.1330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0178   -4.5455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8463   -5.3525    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0258   -5.4387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4591   -6.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2796   -6.0199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6151   -5.2663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1302   -4.5988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3097   -4.6851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4468   -2.8955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4468   -2.0705    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.1612   -3.3080    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8757   -2.8955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5902   -3.3080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3047   -2.8955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
  5 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
 12 17  4  0  0  0  0
  6 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  11
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5185

>  <JC_XSMILES>
FC(F)(F)C1N(CCC2=C1NC3=CC=CC=C23)C(=S)NCC=C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2083

>  <W2 Pf proliferation inhibition EC50 uM>
0.1076

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
70.68

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5186
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 10 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5186

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3)C(=O)CC(C2)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.342

>  <W2 Pf proliferation inhibition EC50 uM>
0.152

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022988506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5187
  Mrv1591402191617072D          

 28 29  0  0  0  0            999 V2000
    3.2649   -6.6981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5049   -6.3771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7985   -6.8034    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1749   -6.2633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4958   -5.5033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3178   -5.5736    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6680   -5.1059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2081   -4.4823    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0182   -4.6382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2883   -5.4177    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5583   -4.0145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3685   -4.1704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9086   -3.5468    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7187   -3.7027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2588   -3.0791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0689   -3.2350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3390   -4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1491   -4.1704    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    8.7989   -4.6382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9887   -4.4823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6385   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8590   -5.2200    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.4181   -4.6800    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.9086   -5.7296    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.0696   -4.7969    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.2447   -4.8128    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.4682   -4.0746    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 13 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  5 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
M  CHG  2  26   1  27  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5187

>  <JC_XSMILES>
CC1=NC=C(N1CCOC(=O)NC(NC2=CC=C(Br)C=C2)C(Cl)(Cl)Cl)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2291

>  <W2 Pf proliferation inhibition EC50 uM>
0.1519

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-519
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2982    1.2210    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308    0.3960    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9962    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -0.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9962   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2337   -0.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -0.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4712   -1.3349    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4712    0.0940    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
  8 22  4  0  0  0  0
 22 23  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-519

>  <JC_XSMILES>
CC1=CC(C)=C2N=C(NS(=O)(=O)C3=CC=CC(=C3)C(O)=O)SC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.693

>  <W2 Pf proliferation inhibition EC50 uM>
1.251

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5191
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 10 16  4  0  0  0  0
  8 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5191

>  <JC_XSMILES>
CSC1=NN2C(C)=C(CC3=CC=CC(F)=C3)C(C)=NC2=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2975

>  <W2 Pf proliferation inhibition EC50 uM>
0.1517

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012820513

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5195
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6081   -2.8265    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1773   -2.3166    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -2.0617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5751   -2.6137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4035   -3.4207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6189   -3.6756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0058   -3.1236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1792   -2.8265    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2960   -0.1085    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
  6 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5195

>  <JC_XSMILES>
COC(=O)C1=C(NC(=O)NN2CCCCC2)ON=C1C3=C(Cl)C=CC=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2771

>  <W2 Pf proliferation inhibition EC50 uM>
0.151

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.016806723

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5196
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
  9 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
  6 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
 20 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  1  0  0  0  0
 32 35  1  0  0  0  0
 19 35  1  0  0  0  0
M  CHG  2  16   1  17  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5196

>  <JC_XSMILES>
CCOC(=O)C1=C(N)N(C2=CC=CC(=C2)[N+]([O-])=O)C3=C(C1C4=CC=C(Br)C=C4)C(=O)CC(C)(C)C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.26

>  <W2 Pf proliferation inhibition EC50 uM>
0.1504

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5197
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.8018   -4.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498   -4.0609    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076    1.3686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3444    0.7556    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473    2.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8543    2.3248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1092    3.1094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5572    3.7225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8121    4.5071    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.2498    3.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
  9 26  4  0  0  0  0
 22 26  4  0  0  0  0
M  CHG  1  11   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5197

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C[N+](CC(=O)C3=CC=C(Cl)C=C3)=C4CCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.641

>  <W2 Pf proliferation inhibition EC50 uM>
0.1502

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.05

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-520
  Mrv1591402191617072D          

 42 46  0  0  0  0            999 V2000
    4.1244  -10.5244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0910  -10.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2398  -11.6224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849  -12.4070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599  -12.4070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9049  -11.6224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6749  -13.0745    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0105  -13.8282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5256  -14.4956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7051  -14.4094    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3695  -13.6557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8545  -12.9882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2202  -15.0768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5557  -15.8305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3762  -15.9167    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0708  -16.4979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4064  -17.2516    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9214  -17.9190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2570  -18.6727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7721  -19.3401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0484  -19.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5333  -19.9213    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1978  -20.6750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6827  -21.3425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5032  -21.2562    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3471  -22.0961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8321  -22.7636    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4965  -23.5172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9814  -24.1847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8019  -24.0985    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1375  -23.3448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6525  -22.6773    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2868  -24.7659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0319  -25.5505    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6993  -26.0354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3668  -25.5505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7793  -26.2650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1204  -25.2150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1118  -24.7659    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3840  -18.5002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1010  -17.8328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
 31 34  1  0  0  0  0
 34 35  2  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  1  0  0  0  0
 37 40  1  0  0  0  0
 34 40  1  0  0  0  0
 22 41  4  0  0  0  0
 41 42  4  0  0  0  0
 19 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-520

>  <JC_XSMILES>
CC1(C)CN=C(S1)N2CCN(CC2)CC(O)COC3=CC=C(OCC(O)CN4CCN(CC4)C5=NCC(C)(C)S5)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.423

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5200
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    0.8205    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
  7 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
  5 25  1  0  0  0  0
 25 26  2  0  0  0  0
  6 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 27 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5200

>  <JC_XSMILES>
CC(C)CN1C(C(C(=O)NC2=CC(F)=CC=C2F)C3=CC=CC=C3C1=O)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2603

>  <W2 Pf proliferation inhibition EC50 uM>
0.15

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.064516129

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5201
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -3.6791   10.1277    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501   10.1277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    8.8902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    8.8902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    8.4777    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2337    7.7632    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4087    9.1922    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    8.0652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    7.2402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    7.2402    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.0027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186    4.2803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637    3.4956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387    3.4956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837    4.2803    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 21 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5201

>  <JC_XSMILES>
ClC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=S)NCC3CCCO3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.653

>  <W2 Pf proliferation inhibition EC50 uM>
0.1492

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5203
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
    7.7359   -5.6400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3234   -6.3545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5165   -6.1830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1839   -5.0269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 20 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5203

>  <JC_XSMILES>
C1CCN(C1)CCN2CCN(CC2)C3=CC=CC(=N3)C4=CC=CC5=CC=CN=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0584

>  <W2 Pf proliferation inhibition EC50 uM>
0.1034

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
70.09

>  <Powder data?>
Yes

>  <IFI value>
0.04

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5204
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
    4.5063    0.8732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0716    1.5745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2470    1.5487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8124    2.2499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    2.2242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5978    1.4972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0325    0.7959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8571    0.8217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2917    0.1205    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1163    0.1462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7732    1.4714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2406    0.8414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5232    1.1532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4626    1.9760    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3386    2.1727    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7286    2.8997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2940    3.6009    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5306    3.5751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9652    4.2764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7898    4.2506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2244    4.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8344    5.6789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0098    5.7046    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5752    5.0034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5532    2.9254    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2244    0.7186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1986   -0.1060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8999   -0.5406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6269   -0.1506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6526    0.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9514    1.1086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 16 25  4  0  0  0  0
  5 25  4  0  0  0  0
 13 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5204

>  <JC_XSMILES>
COC1=CC2=C(C=C1OC)C3=NC(=NN3C(NCC4=CC=CN=C4)=N2)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1825

>  <W2 Pf proliferation inhibition EC50 uM>
0.1475

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5205
  Mrv1591402191617072D          

 51 57  0  0  0  0            999 V2000
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -3.5558    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -4.9848    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0087   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0681   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0681   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7825    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4970   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4970   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7825   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 34 39  1  0  0  0  0
 37 40  1  0  0  0  0
 40 41  2  0  0  0  0
 40 42  1  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 42 47  4  0  0  0  0
 29 48  4  0  0  0  0
 48 49  4  0  0  0  0
 49 50  4  0  0  0  0
 27 50  4  0  0  0  0
 50 51  4  0  0  0  0
 25 51  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5205

>  <JC_XSMILES>
O=C(CN1CCN(CC1)C(=O)C2=CC=CC=C2)NC3=CC=C(C=C3)C4=NC5=CC(NC(=O)CN6CCN(CC6)C(=O)C7=CC=CC=C7)=CC=C5O4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2354

>  <W2 Pf proliferation inhibition EC50 uM>
0.1459

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.0375

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5206
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    7.1162    0.2943    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1162    1.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4018    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6873    1.1193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9728    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2584    1.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2584    0.2943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5439   -0.1182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8294    0.2943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8294    1.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5439    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8307    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5452    1.1193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2989    1.4548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5538    2.2395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3608    2.4110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9128    1.7979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7198    1.9694    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   10.6579    1.0133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8509    0.8418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4384    0.1273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6933   -0.6573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1413   -1.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3962   -2.0551    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    8.3343   -1.0989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0794   -0.3143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6314    0.2988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  2 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 13 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5206

>  <JC_XSMILES>
OC(CNCC1=CC=CC=C1)CN2C3=CC=C(Br)C=C3C4=CC(Br)=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3115

>  <W2 Pf proliferation inhibition EC50 uM>
0.01355

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.3

>  <Powder data?>
Yes

>  <IFI value>
0.052631579

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5207
  Mrv1591402191617072D          

 33 37  0  0  1  0            999 V2000
    2.2396   -3.8791    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.2396   -3.0541    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.9540   -2.6416    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -2.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -3.0541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -2.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -1.8166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -1.8166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -0.5791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    0.6584    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2396    1.0709    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.2396    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    2.3084    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.0915    1.7584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0915    1.2084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    0.6584    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.8959    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.3830    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    0.6584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.8959    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 13 12  1  6  0  0  0
 14 13  1  6  0  0  0
 14 15  1  0  0  0  0
 16 15  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 21 20  1  0  0  0  0
 16 21  1  0  0  0  0
 21 22  1  1  0  0  0
 22 23  2  0  0  0  0
 13 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 24 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5207

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(=C1)C(=O)O[C@@H]([C@@H]2C[C@@H]3CCN2C[C@@H]3C=C)C4=CC=NC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.396

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01454

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009259259

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5208
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5082    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
  7 21  4  0  0  0  0
 21 22  4  0  0  0  0
  4 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5208

>  <JC_XSMILES>
CN(C)C1=CC=C(NC(=O)C2C3OC(C=C3)C2C(O)=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1201

>  <W2 Pf proliferation inhibition EC50 uM>
0.0477

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
32.81

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-521
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -4.2868   -0.8250    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -5.0013    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-521

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)N2CCN(CC2)C(=S)NCC=C

>  <PF proliferation inhibition 3D7 EC50 uM>
2.369

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5210
  Mrv1591402191617072D          

 34 39  0  0  0  0            999 V2000
    1.3363   -4.7113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3073   -3.8868    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.5788   -3.4996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1207   -3.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8492   -3.5498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8782   -2.7253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1787   -2.2880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2076   -1.4635    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4919   -1.0262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2204   -1.4133    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4629   -0.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1725    0.3212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0841    1.2649    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6349    1.1456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4025    1.4739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8583    0.7254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0550    0.3597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8811    0.4621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4594   -0.1263    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9973    1.2836    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7337    1.6554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1857    2.3456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5574    1.6092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2637    1.6800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1776    2.5004    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8451    2.9853    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4239    2.8361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3378    3.6566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4158    3.9923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5019    4.8128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1656    5.2976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9193    4.9619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0054    4.1414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5498   -2.6751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 23  1  0  0  0  0
 20 24  1  0  0  0  0
 14 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
  7 34  4  0  0  0  0
  3 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5210

>  <JC_XSMILES>
CSC1=CC=CC(NC(=O)C2C3OC4(C=C3)C2C(=O)N(C5CC5)C4C(=O)NC6CCCCC6)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.753

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01448

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5214
  Mrv1591402191617072D          

 36 40  0  0  1  0            999 V2000
   -2.0473   -0.5791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3328   -0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3328    0.6584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0473    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0473    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3328    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3328    3.1334    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    1.8959    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.8106    1.0709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    0.6584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396    1.0709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -0.5791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -1.8166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -0.5791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -2.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -3.4666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7001   -2.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3501   -2.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771    2.9959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771    2.4459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396    1.8959    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    4.3709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 11 10  1  0  0  0  0
 11 12  1  1  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 11 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 25 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 27 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  2  0  0  0  0
 10 35  4  0  0  0  0
  6 35  4  0  0  0  0
 35 36  4  0  0  0  0
  3 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5214

>  <JC_XSMILES>
COC1=CC=C2N=CC=C([C@H](OC(=O)C3=CC=C(C=C3)C(C)(C)C)C4CC5CCN4CC5C=C)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02598

>  <W2 Pf proliferation inhibition EC50 uM>
0.1029

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
72.45

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5215
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  -12.1460   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  -12.8605   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -13.5749   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.8605   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 20 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 22 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
  7 39  4  0  0  0  0
  3 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5215

>  <JC_XSMILES>
CCC1=CC=CC(NC(=O)N2CCN(CC2C)C(=O)C3=NC(=NC(C)=C3C(=O)OC(C)C)C4=CC=CC=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.719

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01415

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5218
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
    7.4678    4.2525    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.4722    3.4275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1888    3.0189    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1933    2.1938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4810    1.7776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7644    2.1863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7599    3.0113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4854    0.9526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6784    1.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3054    1.0432    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6449    0.2913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0348   -0.2640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3181    0.1447    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 19 24  4  0  0  0  0
 17 25  4  0  0  0  0
 13 25  4  0  0  0  0
  8 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
  8 29  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5218

>  <JC_XSMILES>
FC1=CC=C(C=C1)C5(CCCSC2=NN=C3C(NC4=CC=CC=C34)=N2)OCCO5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.4

>  <W2 Pf proliferation inhibition EC50 uM>
0.141

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046728972

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5223
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3022   -5.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7871   -6.5979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6076   -6.5117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9431   -5.7580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7636   -5.6718    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4582   -5.0906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 12 11  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 17 23  4  0  0  0  0
 11 24  4  0  0  0  0
  8 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
  9 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5223

>  <JC_XSMILES>
CC1=CC=C(C=C1)N2C(=CC(C=NNC(=O)C3=CC=CC(O)=C3)=C2C4=CC=CC=C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1501

>  <W2 Pf proliferation inhibition EC50 uM>
0.1389

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5224
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 16 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5224

>  <JC_XSMILES>
COC1=CC=CC=C1N2CCN(CC2)CC3=CC(C)=C(C)C=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.383

>  <W2 Pf proliferation inhibition EC50 uM>
0.0805

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
58.01

>  <Powder data?>
Yes

>  <IFI value>
0.029411765

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5226
  Mrv1591402191617072D          

 40 45  0  0  0  0            999 V2000
    2.6242   -8.3540    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0722   -7.7409    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2652   -7.9124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7132   -7.2993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9681   -6.5147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -5.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.1599    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919   -4.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8370   -5.3870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0300   -5.5585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7751   -6.3432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3271   -6.9562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 17 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 16 32  4  0  0  0  0
 27 32  4  0  0  0  0
  7 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
  5 39  4  0  0  0  0
 39 40  4  0  0  0  0
  2 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5226

>  <JC_XSMILES>
OC1=CC=C(CC(C(=O)N2CCC(CC2)N3C(CC4=CC=C(F)C=C4)=NC5=CC=CN=C35)C6=CC=CC=C6)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.351

>  <W2 Pf proliferation inhibition EC50 uM>
0.1384

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.070707071

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5228
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  5 26  4  0  0  0  0
 26 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5228

>  <JC_XSMILES>
ClC1=CC=C2C(NCCCCNC(=O)CCC3=CC=CC=C3)=CC=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1419

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01377

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037735849

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5230
  Mrv1591402191617072D          

 13 13  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5230

>  <JC_XSMILES>
CC(=O)NCCC1=CC=C(O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.671

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01374

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.014814815

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5232
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 11 18  2  0  0  0  0
  2 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5232

>  <JC_XSMILES>
O=C1C2=CC=CC=C2C(=O)C(N3CCCCC3)=C1N4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1374

>  <W2 Pf proliferation inhibition EC50 uM>
0.0341

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
24.88

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-524
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6704   -3.9817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9918   -4.8246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6044   -4.1538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1401   -4.9002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9525   -5.0435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2347   -5.8188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7044   -6.4507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8919   -6.3075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6098   -5.5322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
  8 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 16 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-524

>  <JC_XSMILES>
CCOC(=O)C(=O)N1C2=CC=C(C)C=C2C(C)(CC1(C)C)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.133

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.010752688

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5241
  Mrv1591402191617072D          

 47 52  0  0  0  0            999 V2000
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0032   -5.3493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4817   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1461   -6.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6744   -6.8566    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6310   -7.4378    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2955   -8.1915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7804   -8.8589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6009   -8.7727    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9365   -8.0190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4515   -7.3516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0858   -9.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7503  -10.1938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9298  -10.2801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5942  -11.0337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0791  -11.7012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8996  -11.6149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2352  -10.8613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9063   -9.3539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3912  -10.0213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2117   -9.9351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5473   -9.1814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0623   -8.5140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2419   -8.6002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5204   -0.7027    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1335   -1.2547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 27 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 10 40  1  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  1  0  0  0  0
 44 45  1  0  0  0  0
 43 46  4  0  0  0  0
 46 47  4  0  0  0  0
 40 47  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  13
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5241

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C(N=C(N2)SCCCCC(=O)N3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5)C6=CC=C(OC)C=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.185

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01341

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009259259

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5243
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 24  1  0  0  0  0
 21 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 10 30  1  0  0  0  0
  6 30  2  0  0  0  0
 30 31  1  0  0  0  0
  7 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 35 38  4  0  0  0  0
 38 39  4  0  0  0  0
 32 39  4  0  0  0  0
M  CHG  2  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5243

>  <JC_XSMILES>
CCOC(=O)C1C(CC2=C(C(C3=CC=C(C=C3)[N+]([O-])=O)C(=C(C)N2)C(=O)OCC)C1=O)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.685

>  <W2 Pf proliferation inhibition EC50 uM>
0.1337

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5244
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -3.7120   15.6448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0476   14.8912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5627   14.2237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8982   13.4701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7187   13.3838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0543   12.6301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5693   11.9627    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9049   11.2090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4200   10.5416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5950   10.5416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3400    9.7570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0075    9.2720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6749    9.7570    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0075    8.4470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7220    8.0345    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2930    8.0345    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2930    7.2095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8805    6.4951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7055    6.4951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2036   14.0513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8681   14.8049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 19  1  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5244

>  <JC_XSMILES>
CC1=CC=C(CSCC2=CC=C(O2)C(=O)NC3CC3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.418

>  <W2 Pf proliferation inhibition EC50 uM>
0.1327

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5245
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  2 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5245

>  <JC_XSMILES>
CC(NCC1=CC=CC=C1)C2=CC(Cl)=CC=C2O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.592

>  <W2 Pf proliferation inhibition EC50 uM>
0.0972

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
73.27

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5248
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    2.2308   -4.4153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7459   -3.7479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9254   -3.8341    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0815   -2.9942    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5966   -2.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7716   -2.3268    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5166   -1.5422    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2680   -1.2872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4395   -0.4803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8811   -1.8393    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1841   -1.0572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7027   -0.3872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8515   -1.5422    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7361   -0.4441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4812    0.3405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0332    0.9536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8402    0.7820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0951   -0.0026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5431   -0.6157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3922    1.3951    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.1373    2.1798    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.1992    1.2236    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
  7 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
  5 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5248

>  <JC_XSMILES>
CC(=O)NC1=NN(C(C)=O)C(C)(S1)C2=CC=C(C=C2)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.497

>  <W2 Pf proliferation inhibition EC50 uM>
0.1318

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5249
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
    5.6370   -6.5971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -5.7721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -5.3596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -5.7721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -4.5346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -4.1221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -3.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -2.8846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -3.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -4.1221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -2.0596    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -1.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -0.8221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -0.4096    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935   -0.4096    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935    0.4154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791    0.8279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791    1.6529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935    2.0654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080    1.6529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080    0.8279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935   -2.0596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935   -2.8846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791   -3.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0646   -2.8846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0646   -2.0596    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791   -1.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -1.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3514   -2.0596    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -0.8221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3514   -0.4096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4377    0.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2446    0.5824    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6571   -0.1320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4641   -0.3036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7190   -1.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1670   -1.7013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3600   -1.5298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1051   -0.7451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 11 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 31 39  4  0  0  0  0
 34 39  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  33
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5249

>  <JC_XSMILES>
COC(=O)C1=CC=C(C=C1)N(C(C(=O)NC2CCCCC2)C3=CC=CN=C3)C(=O)CC4=CNC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2325

>  <W2 Pf proliferation inhibition EC50 uM>
0.1317

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.036363636

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5250
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
  6 11  4  0  0  0  0
  3 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 12 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 20 26  4  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5250

>  <JC_XSMILES>
OC1=C(C=CC2=CC=CN=C12)C(NC3=CC=CC=N3)C4=CC=CC(Cl)=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1743

>  <W2 Pf proliferation inhibition EC50 uM>
0.1315

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5252
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -0.7145    2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    1.7605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    3.1895    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6081   -2.8265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4366   -3.6335    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8011   -2.6550    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4151   -2.9980    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
  9 28  4  0  0  0  0
  5 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5252

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(NC(=S)N2CCCC2C3=CC=CC=C3C(F)(F)F)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2135

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01299

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018181818

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5253
  Mrv1591402191617072D          

 43 49  0  0  0  0            999 V2000
    6.5888    3.9139    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7654    3.1081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1558    2.5522    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3325    1.7463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1187    1.4963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2954    0.6905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6858    0.1346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8996    0.3845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7229    1.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9367    1.4403    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8667    2.2624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2360    2.7942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1662    1.6853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5828    0.7397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4049    0.8096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9521    1.2715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2752    0.7999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5283    1.1503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4584    1.9723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1353    2.4439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0654    3.2660    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8822    2.0935    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4140    2.7242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0816    0.4405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6912    0.9964    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2582   -0.3653    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0444   -0.6153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2211   -1.4212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6115   -1.9771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8253   -1.7271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6486   -0.9213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7882   -2.7829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1786   -3.3389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3552   -4.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7457   -4.7006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9594   -4.4507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7828   -3.6448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3924   -3.0889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5516    2.8581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2160    3.3473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8865    2.8666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6365    2.0804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8116    2.0751    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  2  0  0  0  0
 20 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  1  0  0  0  0
 12 23  1  0  0  0  0
  6 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
 29 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
  2 39  1  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 39 43  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5253

>  <JC_XSMILES>
O=C(NC1=CC(=CC=C1N2CC3CC(C2)C4=CC=CC(=O)N4C3)C(=O)N5CCC(CC5)CC6=CC=CC=C6)C7=CC=CS7

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0744

>  <W2 Pf proliferation inhibition EC50 uM>
0.0644

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
49.68

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5254
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
  6 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 17 25  4  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5254

>  <JC_XSMILES>
CCOC1=CC2=C(C=C1OCC)C(NCC2)C3=CC(OC)=C(O)C=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.362

>  <W2 Pf proliferation inhibition EC50 uM>
0.0958

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
74.16

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5256
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  1  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  3 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5256

>  <JC_XSMILES>
N1N(N(N=C1C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1368

>  <W2 Pf proliferation inhibition EC50 uM>
0.1291

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.090909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5258
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    0.8205    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
  7 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
  5 25  1  0  0  0  0
 25 26  2  0  0  0  0
  6 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 27 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5258

>  <JC_XSMILES>
CC(C)CN1C(C(C(=O)NC2=CC=C(F)C=C2F)C3=CC=CC=C3C1=O)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2188

>  <W2 Pf proliferation inhibition EC50 uM>
0.1286

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.060606061

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5259
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  1  0  0  0  0
 10 24  1  0  0  0  0
  5 24  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5259

>  <JC_XSMILES>
COC(=O)C1C(C)CC2=C(C(CC(=O)N2)C3=CC=C(Cl)C=C3Cl)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.991

>  <W2 Pf proliferation inhibition EC50 uM>
0.1284

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-526
  Mrv1591402191617072D          

 15 16  0  0  0  0            999 V2000
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -3.1499    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1661   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9866   -3.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -2.9774    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8372   -2.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0168   -2.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
  6 14  4  0  0  0  0
  3 14  4  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-526

>  <JC_XSMILES>
CSC1=NN=C(CN2CCSCC2)N1C

>  <PF proliferation inhibition 3D7 EC50 uM>
2.026

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5261
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    1.3222    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242    0.4614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492    1.8904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -0.4741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -2.9491    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -2.9491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1331   -4.2590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8781   -5.0437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0531   -5.0437    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7982   -4.2590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5682   -5.7111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9038   -6.4648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7243   -6.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0598   -7.3047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5749   -7.9721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7544   -7.8859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4189   -7.1322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -1.7116    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 12 28  4  0  0  0  0
  8 28  4  0  0  0  0
 28 29  2  0  0  0  0
 10 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 30 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5261

>  <JC_XSMILES>
CC(C)(C)NC(=O)C1=CN(C=C(C(=O)NC2CCN(C2)CC3=CC=CC=C3)C1=O)C4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1878

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01277

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009708738

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5263
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    2.8340    0.2762    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8340   -0.5488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5014   -1.0338    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2465   -1.8184    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4215   -1.8184    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.0338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -0.7788    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2637    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -0.7788    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    0.0058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830    0.6732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526    1.4269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034    0.5870    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884    1.2544    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3088    1.1682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7938    1.8357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6142    1.7494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0992    2.4169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7636    3.1705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2485    3.8380    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9431    3.2568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6076    4.0104    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.4582    2.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    0.0058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119    0.6732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763    1.4269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613    2.0944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817    2.0081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173    1.2544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324    0.5870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667    2.6756    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.7311    3.4292    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.8871    2.5893    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 14 13  1  4  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 16 23  4  0  0  0  0
 10 24  4  0  0  0  0
  7 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 28 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
M  CHG  2  31   1  32  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5263

>  <JC_XSMILES>
NC1=NON=C1N2N=NC(C(=O)NN=CC3=CC=C(F)C(Br)=C3)=C2C4=CC=C(C=C4)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2915

>  <W2 Pf proliferation inhibition EC50 uM>
0.1276

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5266
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633    1.9817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6484    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3629    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6484    3.5730    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3629    3.9855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3629    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0774    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7918    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5063    5.2230    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.7918    3.9855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0774    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0774    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  2  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
  4 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  3 17  4  0  0  0  0
 12 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5266

>  <JC_XSMILES>
CC(N1N2C(C)=CC(=O)N=C2C3=CC=CC=C13)C(=O)NC4=CC=C(F)C=C4C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.283

>  <W2 Pf proliferation inhibition EC50 uM>
0.1265

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5267
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769    2.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8839    2.3061    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8220    3.2623    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0150    3.4338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4630    2.8207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3440    2.9922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5989    3.7769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4059    3.9484    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9579    3.3353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0469    4.3900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7601    4.2184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2700   -1.8242    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  4  0  0  0  0
 14 21  4  0  0  0  0
  9 22  4  0  0  0  0
 22 23  4  0  0  0  0
  7 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5267

>  <JC_XSMILES>
CCC1=CC=CC2=C1N(CC(=O)NC3=CC=C(OC)C=C3)C=C2C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2253

>  <W2 Pf proliferation inhibition EC50 uM>
0.1265

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5268
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    0.8205    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 11 18  4  0  0  0  0
  7 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
  5 25  1  0  0  0  0
 25 26  2  0  0  0  0
  6 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 27 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5268

>  <JC_XSMILES>
CC(C)CN1C(C(C(=O)NC2=CC=C(F)C(Cl)=C2)C3=CC=CC=C3C1=O)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1206

>  <W2 Pf proliferation inhibition EC50 uM>
0.1204

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>95.2

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5269
  Mrv1591402191617072D          

 41 44  0  0  0  0            999 V2000
   -3.2405   -3.2091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7004   -2.5855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8903   -2.7414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3502   -2.1177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5401   -2.2736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8101   -1.8059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0802   -2.5855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3502   -1.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1604   -1.3382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7004   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5106   -0.8704    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0507   -0.2468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8608   -0.4027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4009    0.2209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2110    0.0650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4811   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9410   -1.3382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1308   -1.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2912   -0.8704    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8313   -0.2468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5612   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7806   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0011   -1.9200    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5602   -1.3800    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0507   -2.4296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8608   -2.5855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4009   -1.9618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1308   -3.3650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5908   -3.9887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8608   -4.7682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7806   -3.8327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5106   -3.0532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7004   -2.8973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2700   -3.0532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5401   -3.2091    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8101   -3.9887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2700   -4.6123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5401   -4.4564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8101   -3.6768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6203   -3.5209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 12 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 26 33  4  0  0  0  0
 33 34  1  0  0  0  0
  5 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 35 40  4  0  0  0  0
 40 41  4  0  0  0  0
  3 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5269

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=C(C=C2)N(C)C)S(=O)(=O)C3=C(C)C=C(C)C=C3C)=C4N=CC=CC4=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.533

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01335

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.56

>  <Powder data?>
No

>  <IFI value>
0.027522936

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-527
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3339   -2.4026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -1.6180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -1.6180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6687   -2.4026    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
  2 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 14 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-527

>  <JC_XSMILES>
CC(NC(=O)CC1=CC=C(F)C=C1)C(N2CCOCC2)C3=CC=CS3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.012

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.02

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5271
  Mrv1591402191617072D          

 20 20  0  0  0  0            999 V2000
   -1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
  6 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5271

>  <JC_XSMILES>
CCOC(=O)C(=CNC1=CC=C(I)C=N1)C(=O)OCC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1898

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01257

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.025316456

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5273
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    0.4210    3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7780   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2629    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7780    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  1  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5273

>  <JC_XSMILES>
ClC1=CC=C(CN2C3=C(CCC3)C(=N)C4=C2CCC4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0627

>  <W2 Pf proliferation inhibition EC50 uM>
0.125

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5274
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -1.3144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
  9 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 19 20  1  0  0  0  0
 13 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 19 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 31 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5274

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=C(Cl)C=C4)C(=O)OC5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2605

>  <W2 Pf proliferation inhibition EC50 uM>
0.1249

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5275
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5690   -3.3498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0993   -4.2683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1027   -5.9945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0421   -5.9945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3242   -6.7697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7939   -7.4017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9815   -7.2585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4512   -7.8904    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.6993   -6.4832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2296   -5.8512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
  6 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
 25 34  1  0  0  0  0
  5 34  4  0  0  0  0
 34 35  4  0  0  0  0
  2 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5275

>  <JC_XSMILES>
CC1=CC=C2N(C(=O)COC3=CC=C4C=CC=CC4=C3)C(C)(C)CC(C)(C5=CC=C(Cl)C=C5)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.1242

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5276
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -2.6462   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -4.2703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -4.2703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  7  6  1  4  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
  6 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5276

>  <JC_XSMILES>
COC1=CC=C(C=NNC2=NC3=CC(Cl)=CC=C3N2)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2387

>  <W2 Pf proliferation inhibition EC50 uM>
0.1114

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>89.79

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5277
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    3.2704    5.6645    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.9849    5.2520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    5.6645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138    5.2520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283    5.6645    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.4138    4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    3.1895    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283    3.1895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138    1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427    0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138    0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849    0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849    4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 24  1  0  0  0  0
  7 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5277

>  <JC_XSMILES>
ClC1=CC(Cl)=CC(NC(=O)NC2=CC=CC=C2C(=O)NCC3CC3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.184

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01238

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.033898305

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5278
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    0.8205    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  7 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
  5 23  1  0  0  0  0
 23 24  2  0  0  0  0
  6 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5278

>  <JC_XSMILES>
CC(C)CN1C(C(C(=O)NC2=CC=CC=N2)C3=CC=CC=C3C1=O)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.364

>  <W2 Pf proliferation inhibition EC50 uM>
0.1233

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023255814

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-528
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    0.4161   -5.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4944    3.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 12 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
 29 30  1  0  0  0  0
 20 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 10 34  4  0  0  0  0
 19 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-528

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)N2C=C(C3=CC=CC=C3)C4=C(SCC5=CC(C)=CC=C5C)N=CN=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
2.011

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5281
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
  6 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5281

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C(OC)=CC=CC2=C1NC3=CC=C(C=C3)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.592

>  <W2 Pf proliferation inhibition EC50 uM>
0.123

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5282
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5282

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(=O)CC3C4=CC=C(C=C4)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.182

>  <W2 Pf proliferation inhibition EC50 uM>
0.1229

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5284
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
  4 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 29 32  1  0  0  0  0
 32 33  2  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 32 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5284

>  <JC_XSMILES>
NC1=CC(=CC=C1C(=O)NC2=CC=C(C=C2)C3=NCCCN3)C(=O)NC4=CC=C(C=C4)C5=NCCCN5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1898

>  <W2 Pf proliferation inhibition EC50 uM>
0.1226

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.026315789

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5287
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    2.8734    0.4022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0665    0.2306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9104   -0.4368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3584   -1.0499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7389    0.3702    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4534    0.7827    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7934   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809   -0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0309   -1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8514   -2.0382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0229   -2.8452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3084   -3.2577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6954   -2.7056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2222   -4.0782    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8897   -4.5631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6433   -4.2275    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8034   -5.3836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4709   -5.8685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3846   -6.6890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6309   -7.0245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5447   -7.8450    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.9635   -6.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0497   -5.7191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9059   -3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0809   -3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3316   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0809   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9059   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  3  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
 11 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5287

>  <JC_XSMILES>
CC1=C(C(C)=NO1)S(=O)(=O)N(CC(O)CN2CCC(C2)NC(=O)C3=CC=C(F)C=C3)CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.447

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01212

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009708738

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5288
  Mrv1591402191617072D          

 27 31  0  0  0  0            999 V2000
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  3  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 12 25  4  0  0  0  0
 16 25  4  0  0  0  0
 10 26  4  0  0  0  0
 26 27  4  0  0  0  0
  7 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5288

>  <JC_XSMILES>
C1CN(CCO1)C2=CC=C(NC3=CC=NC4=CC5=CC=CC=C5C=C34)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.672

>  <W2 Pf proliferation inhibition EC50 uM>
0.0839

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
69.46

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5290
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    2.7455    0.3751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9859   -0.4141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7656   -0.6836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4201   -0.1813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.3798    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.5649   -1.1296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3886   -1.0832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8406   -1.7734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4689   -2.5099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6452   -2.5563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1932   -1.8661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3856   -2.0347    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7503   -1.5084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9611   -1.7488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6116   -2.4961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7896   -2.5671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3172   -1.8907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6667   -1.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4886   -1.0724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2514    0.6263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4678    0.8841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2991    1.6917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9142    2.2415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7456    3.0491    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.6979    1.9837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8665    1.1761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
  3 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  1  0  0  0  0
 14 19  4  0  0  0  0
  4 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5290

>  <JC_XSMILES>
OC1=C2C(SC3=CC=CC=C3N=C2C4=CC=CC=C14)C5=CC=C(Br)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.337

>  <W2 Pf proliferation inhibition EC50 uM>
0.0577

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>48.02

>  <Powder data?>
Yes

>  <IFI value>
0.010752688

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5292
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    0.5214    4.5181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3009    4.4508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0520    3.7051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0381    5.3694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8539    5.2464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2664    4.5319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9650    3.7640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5261    3.1592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1766    3.5208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0537    2.7050    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5667    4.8082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3346    5.1096    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 16 30  4  0  0  0  0
 24 30  4  0  0  0  0
 11 31  1  0  0  0  0
  4 31  1  0  0  0  0
 31 32  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5292

>  <JC_XSMILES>
CC1(C)C2CCC1(C)C(=O)N(CC(O)CN3C4=CC=C(Cl)C=C4C5=CC(Cl)=CC=C35)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1176

>  <W2 Pf proliferation inhibition EC50 uM>
0.1196

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.02027027

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5293
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    4.2629   -2.1988    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2629   -3.0238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9304   -3.5088    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6754   -4.2934    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8504   -4.2934    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5955   -3.5088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -3.2538    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7387    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -3.2538    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -2.4692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2460   -1.8018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4255   -1.8880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0594   -1.2206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2761   -0.4669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0966   -0.3806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5815   -1.0481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -2.4692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0408   -1.8018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8613   -1.8880    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7053   -1.0481    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1902   -0.3806    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8546    0.3730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3396    1.0405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0040    1.7941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4889    2.4616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3094    2.3754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7943    3.0428    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.6450    1.6217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4654    1.5354    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.1600    0.9542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 10 17  4  0  0  0  0
  7 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 21 20  1  4  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 23 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5293

>  <JC_XSMILES>
NC1=NON=C1N2N=NC(C3=CC=CC=C3)=C2C(=O)NN=CC4=CC=C(F)C(Br)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.342

>  <W2 Pf proliferation inhibition EC50 uM>
0.1194

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5294
  Mrv1591402191617072D          

 19 19  0  0  0  0            999 V2000
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 13 19  4  0  0  0  0
  4 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5294

>  <JC_XSMILES>
CCNC1=NC(NC(C)CC)=NC(ON=C(C)C)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.441

>  <W2 Pf proliferation inhibition EC50 uM>
0.1183

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5295
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.9497   -2.9545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5597   -2.2275    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9943   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6043   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0390   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8636   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2982    0.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9082    1.3045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0836    1.3302    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3428    2.0057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9528    2.7327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3874    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2120    3.4082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1674    1.9800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5574    1.2530    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.1228    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0049    1.3683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9064    0.8095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -0.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0781   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6108   -1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4141   -2.3078    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3745   -1.1947    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3140   -0.3719    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2535   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8189   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
  7 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 21 26  1  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5295

>  <JC_XSMILES>
COC1=CC=C2N(C(=O)C3=CC=CC=C3F)C(C)(C)C4=C(C(=S)SS4)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.652

>  <W2 Pf proliferation inhibition EC50 uM>
0.1179

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5296
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 26 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 23 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5296

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2CC(=O)C3=C(C2)NC(=O)CC3C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.616

>  <W2 Pf proliferation inhibition EC50 uM>
0.1175

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5297
  Mrv1591402191617072D          

 78 78  0  0  0  0            999 V2000
   -0.9355    2.6665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5230    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355    1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8205    0.7388    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3019   -1.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5231   -1.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5394   -1.8414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5394   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8249   -3.0789    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -3.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684   -2.6665    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3808   -3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9683   -4.0954    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2058   -3.3810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -2.6665    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3328   -3.0790    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3328   -3.9040    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0473   -2.6665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7618   -3.0790    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0473   -1.8415    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8723   -1.8415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2848   -2.5560    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2848   -1.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8723   -0.4126    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5868   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3013   -0.4126    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5868    0.8249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8724    1.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2849    1.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1099    1.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8724    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474    2.6664    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474    3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7619    3.9039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329    3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3330    4.7289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6185    3.4914    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2060    4.2059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6185    4.9203    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3810    4.2059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9685    3.4914    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2540    3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2540    4.7289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    2.6664    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.6665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3809    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8251    3.9040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0181    3.7324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8251    4.7290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9685    4.9204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1839    5.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3810    5.6348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2849    3.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1134    4.1878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1099    3.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3013    1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5563    2.0220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0158    0.8249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1098   -1.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7229   -0.5751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5223   -1.8416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6183   -4.0954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4030   -4.3504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2058   -4.8099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8059   -4.5171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5394   -4.3164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3019   -2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4734   -3.3629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5231   -2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  2  0  0  0  0
 36 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  2  0  0  0  0
 40 42  1  0  0  0  0
 42 43  1  0  0  0  0
 42 44  1  0  0  0  0
 44 45  1  0  0  0  0
 45 46  2  0  0  0  0
 45 47  1  0  0  0  0
 47 48  1  0  0  0  0
 48 49  1  0  0  0  0
 49 50  2  0  0  0  0
 49 51  1  0  0  0  0
 51 52  1  0  0  0  0
 52 53  1  0  0  0  0
  4 53  1  0  0  0  0
 53 54  2  0  0  0  0
 51 55  1  0  0  0  0
 55 56  1  0  0  0  0
 55 57  1  0  0  0  0
 47 58  1  0  0  0  0
 58 59  1  0  0  0  0
 58 60  1  0  0  0  0
 38 61  1  0  0  0  0
 61 62  1  0  0  0  0
 61 63  1  0  0  0  0
 34 64  1  0  0  0  0
 64 65  1  0  0  0  0
 64 66  1  0  0  0  0
 30 67  1  0  0  0  0
 67 68  1  0  0  0  0
 67 69  1  0  0  0  0
 21 70  1  0  0  0  0
 70 71  1  0  0  0  0
 70 72  1  0  0  0  0
 17 73  1  0  0  0  0
 73 74  1  0  0  0  0
 73 75  1  0  0  0  0
 13 76  1  0  0  0  0
 76 77  1  0  0  0  0
 76 78  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5297

>  <JC_XSMILES>
CC(C)C1NC(=O)C(C)OC(=O)C(NC(=O)C(OC(=O)C(NC(=O)C(C)OC(=O)C(NC(=O)C(OC(=O)C(NC(=O)C(C)OC(=O)C(NC(=O)C(OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0916

>  <W2 Pf proliferation inhibition EC50 uM>
0.01173

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.277108434

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5298
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    1.3688   -5.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8168   -4.4668    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0717   -3.6821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5197   -3.0690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7747   -2.2844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2226   -1.6713    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4776   -0.8867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5816   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1337   -2.7260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8787   -3.5106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4308   -4.1237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.3283    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2845   -0.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1956   -1.7698    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1029    1.5092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9234    1.4230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0949    0.6160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3805    0.2035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633    1.9817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
  8 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  1  0  0  0  0
 18 24  4  0  0  0  0
 24 25  2  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 16 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 33 34  4  0  0  0  0
 26 34  4  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5298

>  <JC_XSMILES>
COC1=CC(OC)=C(C=C1Cl)N(C)C(=O)C2=CN(C3CCCC3)C(=O)C4=C2C5=CC=CC=C5N4C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0977

>  <W2 Pf proliferation inhibition EC50 uM>
0.0553

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
47.21

>  <Powder data?>
Yes

>  <IFI value>
0.066666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5299
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5299

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Br)C=C3)C(=O)CC(C2)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.378

>  <W2 Pf proliferation inhibition EC50 uM>
0.1163

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-530
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -0.3444    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076    1.3686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473    2.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9368    0.2971    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9937   -0.7363    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
  9 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-530

>  <JC_XSMILES>
CC1=CC=CC=C1N2C3CS(=O)(=O)CC3N(C2=O)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.92

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.047619048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5301
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    0.8205    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  7 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
  5 24  1  0  0  0  0
 24 25  2  0  0  0  0
  6 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5301

>  <JC_XSMILES>
CC(C)CN1C(C(C(=O)NC2=CC=CC=C2F)C3=CC=CC=C3C1=O)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2033

>  <W2 Pf proliferation inhibition EC50 uM>
0.1158

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5304
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5304

>  <JC_XSMILES>
CC1=CC=C(F)C=C1NC(=O)C2=CC(Cl)=CC=C2NC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1914

>  <W2 Pf proliferation inhibition EC50 uM>
0.1148

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5305
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5305

>  <JC_XSMILES>
ClC1=CC=C2C(NCCCCNC(=O)C3=CC=CC=C3Cl)=CC=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.761

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01366

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.99

>  <Powder data?>
No

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5309
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -2.1434    1.2375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5309

>  <JC_XSMILES>
FC1=CC=C(C=C1)C2=NC3=CC(=CC=C3CN2CC=C)C(=O)NCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01425

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>12.6

>  <Powder data?>
No

>  <IFI value>
0.038961039

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5311
  Mrv1591402191617072D          

 44 45  0  0  1  0            999 V2000
    1.9370   -0.9916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2192   -1.7668    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0317   -1.9100    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.7495   -1.1348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2798   -0.5028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0922   -0.6460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3744   -1.4212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8442   -2.0532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1869   -1.5644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4691   -2.3396    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.9389   -2.9717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2816   -2.4829    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.8119   -1.8508    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5638   -3.2581    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.3763   -3.4013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0335   -3.8901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2211   -3.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5371   -3.2856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6908   -4.3789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8783   -4.2357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -4.8677    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6303   -5.6429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5961   -3.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1264   -2.8284    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7836   -3.3172    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5014   -2.5420    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6890   -2.3988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4068   -1.6236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1587   -3.0308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4409   -3.8061    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3462   -2.8876    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.0640   -2.1124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1840   -3.5196    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.7144   -2.8877    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5305   -3.9321    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5305   -4.7571    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.2450   -5.1695    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1839   -5.1696    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.1839   -5.9946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8984   -4.7572    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.8985   -3.9322    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6129   -5.1697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3274   -4.7572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6128   -5.9947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  6  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  4  0  0  0
  6  7  2  0  0  0  0
  7  8  1  4  0  0  0
  7  9  1  0  0  0  0
 10  9  1  0  0  0  0
 10 11  1  6  0  0  0
 12 10  1  0  0  0  0
 12 13  1  6  0  0  0
 12 14  1  0  0  0  0
 14 15  1  6  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  4  0  0  0
 19 17  1  4  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 26 25  1  0  0  0  0
 26  3  1  0  0  0  0
 26 27  1  6  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 31 29  1  0  0  0  0
 31 32  1  1  0  0  0
 31 33  1  0  0  0  0
 33 34  1  6  0  0  0
 33 35  1  0  0  0  0
 36 35  1  0  0  0  0
 36 37  1  1  0  0  0
 38 36  1  0  0  0  0
 38 39  1  6  0  0  0
 38 40  1  0  0  0  0
 40 41  1  0  0  0  0
 33 41  1  1  0  0  0
 40 42  1  1  0  0  0
 42 43  1  0  0  0  0
 42 44  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5311

>  <JC_XSMILES>
CO[C@H]1C=CC=C(C)C[C@@H](C)[C@H](O)[C@H](C)C=C(C)C=C(OC)C(=O)O[C@@H]1C(C)C(O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@H](O2)C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.491

>  <W2 Pf proliferation inhibition EC50 uM>
0.01127

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.196428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5312
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
M  CHG  2  24   1  25  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5312

>  <JC_XSMILES>
COC1=CC=CC=C1NC(=S)N2CCN(CC2)C3=CC=C(C=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.577

>  <W2 Pf proliferation inhibition EC50 uM>
0.1127

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5313
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5313

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC(C)=C3)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0913

>  <W2 Pf proliferation inhibition EC50 uM>
0.0359

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
31.95

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5315
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    4.8229    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    3.1729    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 12 19  4  0  0  0  0
 10 20  4  0  0  0  0
  2 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5315

>  <JC_XSMILES>
CC1=NC2=NC(C)=NN2C(NC3=CC=C(Cl)C(Cl)=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1227

>  <W2 Pf proliferation inhibition EC50 uM>
0.1119

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5318
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 12 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 11 27  1  0  0  0  0
 27 28  2  0  0  0  0
  9 29  4  0  0  0  0
 29 30  4  0  0  0  0
  6 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5318

>  <JC_XSMILES>
CCCCOC1=CC=C(NC2=C(N3CCCCC3)C(=O)C4=CC=CC=C4C2=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00986

>  <W2 Pf proliferation inhibition EC50 uM>
0.01717

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.5

>  <Powder data?>
Yes

>  <IFI value>
0.109589041

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-532
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 14 21  2  0  0  0  0
 13 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-532

>  <JC_XSMILES>
CCOC1=CC=CC=C1NC(=O)C2C(C3=CC=CC=C3)=C2C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.799

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5320
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 11 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 10 26  1  0  0  0  0
 26 27  2  0  0  0  0
  8 28  4  0  0  0  0
 28 29  4  0  0  0  0
  5 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5320

>  <JC_XSMILES>
CC(=O)NC1=CC=C(NC2=C(N3CCCCC3)C(=O)C4=CC=CC=C4C2=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0528

>  <W2 Pf proliferation inhibition EC50 uM>
0.1107

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5321
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -2.5990   -3.6207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3441   -2.8361    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2822   -1.8800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 14 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
  8 28  4  0  0  0  0
 12 28  4  0  0  0  0
  6 29  4  0  0  0  0
 29 30  4  0  0  0  0
  3 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5321

>  <JC_XSMILES>
COC1=CC=C(CN2C(C)=NC3=CC(NC(=O)NC4=CC=CC=C4)=C(C)N=C23)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.373

>  <W2 Pf proliferation inhibition EC50 uM>
0.1103

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5322
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   -4.8946   -6.2491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -6.2491    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -5.0116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -7.4866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6548   -7.9715    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9097   -8.7562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7347   -8.7562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9897   -7.9715    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -4.1866    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235   -2.9491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4669   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4669   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4199    0.0108    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1650    0.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3400    0.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0850    0.0108    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
  4 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 29 31  1  0  0  0  0
 31 32  2  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 31 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5322

>  <JC_XSMILES>
NC1=CC(=CC=C1C(=O)NC2=CC=CC(=C2)C3=NCCN3)C(=O)NC4=CC=CC(=C4)C5=NCCN5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1987

>  <W2 Pf proliferation inhibition EC50 uM>
0.1098

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.026785714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5325
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  7 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 19 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5325

>  <JC_XSMILES>
CCCC(=O)NC(C(C)C)C(=O)N1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.387

>  <W2 Pf proliferation inhibition EC50 uM>
0.0109

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009433962

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5326
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 10 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 15 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5326

>  <JC_XSMILES>
COC1=CC(=CC=C1O)C2CC(=O)NC3=C2C(=O)CC(C3)C4=CC=CC=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.815

>  <W2 Pf proliferation inhibition EC50 uM>
0.1086

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5327
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  3  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 10 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 14 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  1  0  0  0  0
 36 38  4  0  0  0  0
 38 39  4  0  0  0  0
 33 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5327

>  <JC_XSMILES>
CCOC1=CC=CC=C1C2C(C#N)=C(NC(C)=C2C(=O)NC3=CC=CC=C3)SCC(=O)NC4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.352

>  <W2 Pf proliferation inhibition EC50 uM>
0.1069

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.036144578

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5328
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -1.3144    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 12 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 10 25  1  0  0  0  0
 20 25  4  0  0  0  0
 11 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
  6 31  4  0  0  0  0
 31 32  4  0  0  0  0
  3 32  4  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5328

>  <JC_XSMILES>
COC1=CC=C(NC(=O)C2C(N(C3CCCC3)C(=O)C4=CC=CC=C24)C5=CC=CS5)C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1276

>  <W2 Pf proliferation inhibition EC50 uM>
0.1069

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5329
  Mrv1591402191617072D          

 17 17  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5329

>  <JC_XSMILES>
OC(=O)CCCC(=O)NC1=CC=C(C=C1)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
2.077

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01062

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.025423729

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5330
  Mrv1591402191617072D          

 37 42  0  0  0  0            999 V2000
    6.4938   -3.1948    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8053   -3.6493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8546   -4.4728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5925   -4.8418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3247   -4.4618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9125   -5.0408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5434   -5.7787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7276   -5.6557    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0674   -3.2803    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4148   -3.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6133   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2665   -2.8408    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6355   -2.1029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -1.4898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2765   -1.6613    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7245   -1.0482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9175   -1.2198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3655   -0.6067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4415   -0.7782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9935   -0.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7386    0.6195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0684    0.7910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6204    0.1779    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3385   -0.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1454   -0.5337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6975   -1.1468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4425   -1.9314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0798   -2.4553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4004    0.2510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9154    0.9184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4004    1.5858    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1850    1.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    1.7434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6139    1.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6139    0.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    0.0934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1850    0.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  2  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 14 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 13 27  4  0  0  0  0
 27 28  1  0  0  0  0
  9 28  1  0  0  0  0
 25 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 29 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5330

>  <JC_XSMILES>
O=C(CC1=CC=CS1)N2CCOC3=C(OCCC4=CC=CC=N4)C=C(C=C3C2)C5=CSC6=CC=CC=C56

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1792

>  <W2 Pf proliferation inhibition EC50 uM>
0.106

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.019607843

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5331
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 10 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  1  0  0  0  0
M  CHG  2  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5331

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=C(C=C3)[N+]([O-])=O)C(=O)CC(C2)C4=CC=CC=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1144

>  <W2 Pf proliferation inhibition EC50 uM>
0.1054

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.054347826

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5335
  Mrv1591402191617072D          

 44 48  0  0  0  0            999 V2000
    6.3514   -7.0096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -6.5971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -5.7721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -5.3596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -5.7721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -4.5346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -4.1221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -3.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -2.8846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -3.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -4.1221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -2.0596    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -1.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -0.8221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -0.4096    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935   -0.4096    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935    0.4154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791    0.8279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791    1.6529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935    2.0654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080    1.6529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080    0.8279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935   -2.0596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935   -2.8846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791   -3.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0646   -2.8846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0646   -2.0596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3501   -1.6471    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3501   -0.8221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791   -1.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791   -0.8221    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0646   -0.4096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -1.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3514   -2.0596    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -0.8221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3514   -0.4096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4377    0.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2446    0.5824    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6571   -0.1320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4641   -0.3036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7190   -1.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1670   -1.7013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3600   -1.5298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1051   -0.7451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 13 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 23 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 12 33  1  0  0  0  0
 33 34  2  0  0  0  0
 33 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 36 44  4  0  0  0  0
 39 44  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  38
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5335

>  <JC_XSMILES>
CCOC(=O)C1=CC=C(C=C1)N(C(C(=O)NC2CCCCC2)C3=CC=CC(OC)=C3OC)C(=O)CC4=CNC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0542

>  <W2 Pf proliferation inhibition EC50 uM>
0.1039

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.019230769

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5336
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    4.4509   -5.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8989   -4.4309    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919   -4.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8370   -5.3870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0300   -5.5585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6288    1.5387    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  3  0  0  0  0
 15 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 12 23  4  0  0  0  0
 18 23  4  0  0  0  0
  7 24  4  0  0  0  0
  3 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5336

>  <JC_XSMILES>
COC1=CC=CC(NC(=O)CN2C(C)=C(C#N)C3=CC=CC=C23)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0796

>  <W2 Pf proliferation inhibition EC50 uM>
0.1036

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5339
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175   -4.4158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483   -3.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878   -3.3762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489   -2.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227   -3.3151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    4.3034    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    1.4455    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 13 18  4  0  0  0  0
 11 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 33 34  4  0  0  0  0
 28 34  4  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5339

>  <JC_XSMILES>
CC(C)(C)CC(C)(C)NC1=C(N=C2C=CC=CN12)C3=CC=CC=C3OC(=O)C4=CC=C(Cl)C=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.279

>  <W2 Pf proliferation inhibition EC50 uM>
0.01032

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028301887

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5340
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
    9.1814    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669    3.1152    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.8777    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.8777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    0.6402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -1.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -2.6598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2765   -3.1447    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0216   -3.9294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1966   -3.9294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9416   -3.1447    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -1.4223    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -0.1848    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3248   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0393   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0393   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3248   -1.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7538   -1.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5074   -1.4993    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.0595   -2.1124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6470   -2.8268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8400   -2.6553    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 20 24  1  0  0  0  0
  7 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 31 34  1  0  0  0  0
 34 35  2  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 34 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5340

>  <JC_XSMILES>
CC(=O)NC1=CC(=CC=C1C(=O)NC2=CC=C(C=C2)C3=NCCN3)C(=O)NC4=CC=C(C=C4)C5=NCCN5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.323

>  <W2 Pf proliferation inhibition EC50 uM>
0.103

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5343
  Mrv1591402191617072D          

 33 37  0  0  1  0            999 V2000
   -3.8837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.3646    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.2089    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 21 20  1  0  0  0  0
 21 22  1  6  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 19 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 18 32  4  0  0  0  0
 32 33  4  0  0  0  0
 16 33  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  33
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5343

>  <JC_XSMILES>
CCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(N[C@H](C)C5=CC=CC=C5)N=CN=C4N3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.378

>  <W2 Pf proliferation inhibition EC50 uM>
0.02849

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
27.83

>  <Powder data?>
Yes

>  <IFI value>
0.066666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5344
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 24  1  0  0  0  0
 21 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 10 30  1  0  0  0  0
  6 30  2  0  0  0  0
 30 31  1  0  0  0  0
  7 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
M  CHG  2  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5344

>  <JC_XSMILES>
CCOC(=O)C1C(CC2=C(C(C3=CC=C(C=C3)[N+]([O-])=O)C(=C(C)N2)C(=O)OCC)C1=O)C4=CC=CC=C4OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1137

>  <W2 Pf proliferation inhibition EC50 uM>
0.1023

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.069767442

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5345
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -0.5812   -1.3054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -0.4849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    1.3099    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4875    2.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7425    3.2623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1904    3.8754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5494    3.4338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2195   -1.0164    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195   -1.0164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396   -1.0396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 25 26  1  0  0  0  0
 12 27  1  0  0  0  0
  3 27  1  0  0  0  0
 27 28  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5345

>  <JC_XSMILES>
CCN1C(=O)N(CCC(C)C)C2(CCN(CC2)CC3=CC(Cl)=CC=C3O)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.348

>  <W2 Pf proliferation inhibition EC50 uM>
0.1022

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5347
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2427    1.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7124    0.4623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -1.3144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 11 18  1  0  0  0  0
  8 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
  6 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 22 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5347

>  <JC_XSMILES>
CC1=CC=CC2=CC(CNC3CCOC(C)(C)C3)=C(N=C12)N4CCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02139

>  <W2 Pf proliferation inhibition EC50 uM>
0.0397

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
39.05

>  <Powder data?>
Yes

>  <IFI value>
0.017241379

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5348
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -8.2500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.4467   -9.3770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717   -7.9480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171  -10.3125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   11.4315   -9.9000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   10.7171  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
M  CHG  2  23   1  24  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5348

>  <JC_XSMILES>
COCCNC(=S)N1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1756

>  <W2 Pf proliferation inhibition EC50 uM>
0.1012

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-535
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    2.5559    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051    4.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    4.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176    5.4138    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.2426    5.4138    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.0051    6.1283    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  2  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 30 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  2  0  0  0  0
M  CHG  2  33   1  34  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-535

>  <JC_XSMILES>
CN(C1=CC=CC=C1)C2=NC=NC3=C2C(C)=C(S3)C(=O)N4CCN(CC4)C5=CC=C(C=C5)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.651

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5352
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175   -4.4158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483   -3.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878   -3.3762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489   -2.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227   -3.3151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    3.5889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 13 18  4  0  0  0  0
 11 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5352

>  <JC_XSMILES>
CC(C)(C)CC(C)(C)NC1=C(N=C2C=CC=CN12)C3=CC=CC=C3OC(=O)C4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.349

>  <W2 Pf proliferation inhibition EC50 uM>
0.01005

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028301887

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5355
  Mrv1591402191617072D          

 32 37  0  0  0  0            999 V2000
    0.6511   -2.9967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0636   -2.2822    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8886   -2.2822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3011   -1.5677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1261   -1.5677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5386   -2.2822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1261   -2.9967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3011   -2.9967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3636   -2.2822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8485   -2.9496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5935   -3.7343    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1456   -4.3474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9525   -4.1758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5046   -4.7889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2496   -5.5735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6621   -6.2880    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1101   -6.9011    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1963   -7.7216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5289   -8.2065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7752   -7.8710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6890   -7.0505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3564   -6.5655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4427   -5.7451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8906   -5.1320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6331   -2.6947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3476   -3.1072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0620   -2.6947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0620   -1.8697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3476   -1.4572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6331   -1.8697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8485   -1.6148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5935   -0.8301    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
 23 24  4  0  0  0  0
 12 24  4  0  0  0  0
 10 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  1  0  0  0  0
  9 31  1  0  0  0  0
 31 32  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5355

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C(NC3=CC=C4OC5=CC=CC=C5C4=C3)C6=CC=CC=C6C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1424

>  <W2 Pf proliferation inhibition EC50 uM>
0.1

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5357
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
  6 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
 17 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5357

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C=CC=CC2=C1NC3=CC=C(OC)C(OC)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0665

>  <W2 Pf proliferation inhibition EC50 uM>
0.0846

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
85.43

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5358
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    2.2374    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 29 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5358

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4=CC=CC(Cl)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.424

>  <W2 Pf proliferation inhibition EC50 uM>
0.00989

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5359
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5359

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=C(F)C=C3)C(=O)CC(C2)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1879

>  <W2 Pf proliferation inhibition EC50 uM>
0.0982

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.036144578

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-536
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    1.2488    2.5288    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6198    1.7920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4434    1.7448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8144    1.0079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3618    0.3182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8779   -0.3254    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6495   -0.0335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3828   -0.4116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0768    0.0344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0376    0.8585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7317    1.3045    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4649    0.9264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1590    1.3724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1198    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8138    2.6424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5471    2.2644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5863    1.4403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8923    0.9943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3043    1.2366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6103    0.7906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5381    0.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0855   -0.3244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2618   -0.2772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1092    0.4596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3435    1.1494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1671    1.1022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  4  0  0  0  0
  4 20  4  0  0  0  0
  7 20  4  0  0  0  0
  5 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
  2 26  1  0  0  0  0
 21 26  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-536

>  <JC_XSMILES>
O=C1CC2=C(NC3=CC=C(OCC4=CC=CC=C4)C=C23)C5CC=CCC15

>  <PF proliferation inhibition 3D7 EC50 uM>
1.589

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5361
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -5.0013    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 20 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 11 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
  8 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5361

>  <JC_XSMILES>
COCCNC(=O)C1=CC=C(OC2CCN(CC2)CC(C3=CC=CC=C3)C4=CC=CC=C4)C(OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3029

>  <W2 Pf proliferation inhibition EC50 uM>
0.0749

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>76.68

>  <Powder data?>
Yes

>  <IFI value>
0.01369863

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5363
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
  5 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5363

>  <JC_XSMILES>
OC1=CC=C(C=C1CNCCC2=CC=C(F)C=C2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.691

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00974

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.034188034

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5365
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -5.7158    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -5.0013    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -5.0013    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559   -1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309   -0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5365

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=S)NCCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0972

>  <W2 Pf proliferation inhibition EC50 uM>
0.0971

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5366
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    1.4289    5.7750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
 17 22  4  0  0  0  0
 12 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
  5 30  4  0  0  0  0
 30 31  4  0  0  0  0
  2 31  4  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5366

>  <JC_XSMILES>
FC1=CC=C(NC(=O)C2=C3CN(CCC3=NC4=CC=CC=C24)CC5=CC=CC=C5)C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.799

>  <W2 Pf proliferation inhibition EC50 uM>
0.0967

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5368
  Mrv1591402191617072D          

 43 48  0  0  0  0            999 V2000
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599   -2.9980    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9849   -4.4270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1842    1.8695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2448    1.8695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 13 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
  5 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 33 34  4  0  0  0  0
 25 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  2  0  0  0  0
 23 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  2  0  0  0  0
 37 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 40 42  1  0  0  0  0
 40 43  1  0  0  0  0
 35 43  1  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5368

>  <JC_XSMILES>
COC1=CC(=CC=C1OC2=CC=C(C=C2C(F)(F)F)[N+]([O-])=O)C3NC4=CC=C5C=CC=CC5=C4C6=C3C(=O)CC(C)(C)C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2848

>  <W2 Pf proliferation inhibition EC50 uM>
0.0958

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5369
  Mrv1591402191617072D          

 37 43  0  0  0  0            999 V2000
    5.9735   -1.0761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7257   -0.2892    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3975    0.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1798   -0.0724    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1497    0.9765    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8215    1.4554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3247    0.9840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7782    1.6021    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9697    1.4379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3067    1.9288    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6349    1.4499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8828    0.6630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7077    0.6556    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2542    0.0375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0627    0.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8838   -0.6037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4919   -1.1612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3131   -1.9666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5262   -2.2144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9181   -1.6569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0969   -0.8515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3252    0.0550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5730   -0.7319    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5198    0.2338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9622   -0.3743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1569   -0.1954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0910    0.5914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4666    1.1995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2720    1.0207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8295    1.6288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5817    2.4157    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6671    1.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1882    2.4064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5306    3.1570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3518    3.2358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8307    2.5640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4883    1.8134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
  2 15  1  0  0  0  0
  7 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 12 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
 11 30  1  0  0  0  0
 30 31  2  0  0  0  0
  7 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5369

>  <JC_XSMILES>
CN1C(=O)N(C)C2(N=C3SC4=C(N3NC12C5=CC=CC=C5)C(=O)C6=CC=CC=C6C4=O)C7=CC=CC=C7

>  <PF proliferation inhibition 3D7 EC50 uM>
2.827

>  <W2 Pf proliferation inhibition EC50 uM>
0.0955

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.044444444

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5373
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  1  0  0  0  0
 10 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  9 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 25 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5373

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=CC(Cl)=C3Cl)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2072

>  <W2 Pf proliferation inhibition EC50 uM>
0.0937

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.048192771

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5374
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 14 21  4  0  0  0  0
 12 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 11 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 27 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5374

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Cl)C(Cl)=C3)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1432

>  <W2 Pf proliferation inhibition EC50 uM>
0.0492

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
52.58

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5377
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    0.6538   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489    0.8152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227    1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    1.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175    3.0199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483    2.5100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 19 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
 35 36  4  0  0  0  0
 18 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5377

>  <JC_XSMILES>
CCC1=CC=C(C=C1)C(=O)OC2=CC=CC=C2C3=C(NC(C)(C)CC(C)(C)C)N4C=CC(C)=CC4=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.454

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00929

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.074766355

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5379
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 12 19  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5379

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(=C1)C(=O)C2=CC=C(Cl)C(Cl)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.612

>  <W2 Pf proliferation inhibition EC50 uM>
0.0575

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
62.37

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-538
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.6538    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  3 15  1  0  0  0  0
  6 15  4  0  0  0  0
  4 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
M  CHG  1  22   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-538

>  <JC_XSMILES>
CCN1C(\SC2=CC(NC(C)=O)=CC=C12)=C\C3=CC=CC=[N+]3C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.404

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5380
  Mrv1591402191617072D          

 42 42  0  0  0  0            999 V2000
    4.0263   11.1826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2399   10.3857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6565    9.8023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8700    9.0054    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6669    8.7919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2503    9.3753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0472    9.1617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2867    8.4221    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
    2.7033    9.0054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9064    8.7919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3230    9.3753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8700    7.8387    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6565    7.0418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2399    6.4585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0263    5.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6669    8.0522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2503    7.4689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0367    6.6720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7033    7.8387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9168    7.0418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3335    6.4585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5366    6.6720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3230    7.4689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9064    8.0522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9532    6.0886    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
    0.3698    6.6720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4271    6.4585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0104    7.0418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3698    5.5053    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5834    4.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2135    3.3281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4271    5.7188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0104    5.1354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8073    5.3489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5366    5.5053    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3230    4.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9064    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6929    3.3281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3335    5.7188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9168    5.1354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7033    4.3385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  8 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
  8 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 25 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 29 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 25 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 36 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
M  CHG  2   8   1  25   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5380

>  <JC_XSMILES>
CCCN(CCC)[P+](CCC)(N(CCC)CCC)C1=CC=C(C=C1)[P+](CCC)(N(CCC)CCC)N(CCC)CCC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1932

>  <W2 Pf proliferation inhibition EC50 uM>
0.0668

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
72.63

>  <Powder data?>
Yes

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5381
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  4  0  0  0  0
 14 19  4  0  0  0  0
  7 20  4  0  0  0  0
 20 21  4  0  0  0  0
  4 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5381

>  <JC_XSMILES>
CCOC1=CC=C(NC2=CC(=O)OC3=CC=CC=C23)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.61

>  <W2 Pf proliferation inhibition EC50 uM>
0.0919

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5382
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -6.0770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -4.6480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 14 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5382

>  <JC_XSMILES>
CCCCS(=O)(=O)N(C)CCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0688

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00918

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5383
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -9.1474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -9.9320    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -9.1474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6914   -8.8925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0783   -9.4445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7064   -9.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8779   -8.3826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6625   -8.1277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2756   -8.6797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1041   -9.4867    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0602   -8.4248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6733   -8.9768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4579   -8.7219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6295   -7.9149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4141   -7.6599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5856   -6.8530    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0272   -8.2120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8118   -7.9570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4249   -8.5091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2095   -8.2541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3811   -7.4472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7680   -6.8951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9833   -7.1501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.1657   -7.1922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.8331   -7.6771    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.5006   -7.1922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.2456   -6.4076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.4206   -6.4076    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.9357   -5.7402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0164   -7.3628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2318   -7.6178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1879   -6.5559    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.5748   -6.0038    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -4.9725   -6.3009    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2648   -7.8306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5198   -8.0855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  2  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 24 27  1  0  0  0  0
 27 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 27 31  1  0  0  0  0
 31 32  1  0  0  0  0
 17 33  4  0  0  0  0
 33 34  4  0  0  0  0
 14 34  4  0  0  0  0
 33 35  1  0  0  0  0
 35 36  1  0  0  0  0
 35 37  2  0  0  0  0
 10 38  4  0  0  0  0
 38 39  4  0  0  0  0
  7 39  4  0  0  0  0
M  CHG  2  35   1  36  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5383

>  <JC_XSMILES>
CN1CCN=C1C2=CC=C(NC(=O)C3=CC=C(C(=O)NC4=CC=C(C=C4)C5=NCCN5C)C(=C3)[N+]([O-])=O)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0725

>  <W2 Pf proliferation inhibition EC50 uM>
0.00913

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.108108108

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5387
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 10 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 15 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5387

>  <JC_XSMILES>
CCCCN(C)CC1=CC(=CC=C1O)C2=CC=CC(OC)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.875

>  <W2 Pf proliferation inhibition EC50 uM>
0.0903

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034188034

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5389
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5389

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4=CC=CC=C4C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.757

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00903

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.038095238

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5393
  Mrv1591402191617072D          

 17 20  0  0  0  0            999 V2000
    2.7865    1.2324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3309    1.9202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5075    1.8695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1397    1.1310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5264    0.5791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4830   -0.2447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0349   -0.8579    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8588   -0.9013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5953    0.4432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2626    0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4720   -0.3495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1638   -0.7990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8990   -0.4246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9424    0.3993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2506    0.8488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5154    0.4744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9635    1.0876    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  1  0  0  0  0
  1 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  4 17  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5393

>  <JC_XSMILES>
C1CCC23CCNC(C2C1)C4=CC=CC=C4O3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2696

>  <W2 Pf proliferation inhibition EC50 uM>
0.0436

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.64

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5394
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
  4 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 13 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 12 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5394

>  <JC_XSMILES>
CC(=O)N(C1=CC=CC=C1C)C2=C(N3CCCCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.034

>  <W2 Pf proliferation inhibition EC50 uM>
0.01812

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.25

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5395
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849    2.9980    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599    4.4270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    0.8205    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
  7 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
  5 27  1  0  0  0  0
 27 28  2  0  0  0  0
  6 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 29 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5395

>  <JC_XSMILES>
CC(C)CN1C(C(C(=O)NC2=CC=CC(=C2)C(F)(F)F)C3=CC=CC=C3C1=O)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1946

>  <W2 Pf proliferation inhibition EC50 uM>
0.0888

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5396
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4215   -0.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2465   -0.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5014   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8340   -1.9524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
 16 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 15 25  4  0  0  0  0
 25 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 10 33  4  0  0  0  0
  6 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5396

>  <JC_XSMILES>
CCOC(=O)C1=CC=CC(NC(=O)CC2N(C3CCCC3)C(=O)N(C2=O)C4=CC=CC=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2755

>  <W2 Pf proliferation inhibition EC50 uM>
0.0884

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5397
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  4  0  0  0  0
 24 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5397

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3F)C(=O)CC(C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.231

>  <W2 Pf proliferation inhibition EC50 uM>
0.0884

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023255814

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5399
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659    3.6664    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    5.0953    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
 35 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5399

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4=CC=C(Cl)C=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.728

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00881

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.056603774

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5400
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    2.3596   -3.4255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6451   -3.8380    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6451   -4.6630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3596   -5.0755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3596   -5.9005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6451   -6.3130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9307   -5.9005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9307   -5.0755    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2162   -6.3130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2162   -7.1380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4983   -7.5505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2127   -7.1380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9272   -7.5505    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2127   -6.3130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9272   -5.9005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6417   -6.3130    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3562   -5.9005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0107   -6.4028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8286   -6.2951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3308   -5.6406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2232   -4.8226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5686   -4.3204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7507   -4.4281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2485   -5.0826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4983   -5.9005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 17 24  1  0  0  0  0
 14 25  4  0  0  0  0
  9 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5400

>  <JC_XSMILES>
COC1=CC=CC(=N1)C2=CC=C(O)C(CNC3CCCCCCC3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0719

>  <W2 Pf proliferation inhibition EC50 uM>
0.02031

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.14

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5401
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -4.2868    6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1118    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4618    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 22 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 13 35  4  0  0  0  0
 35 36  4  0  0  0  0
 10 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5401

>  <JC_XSMILES>
CC(C)(C)CC(=O)NCC1=CC=C(OC2CCN(CC2)CC(C3=CC=CC=C3)C4=CC=CC=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.155

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00877

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.070422535

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5402
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659    3.6664    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5402

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4=CC=C(F)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.897

>  <W2 Pf proliferation inhibition EC50 uM>
0.0087

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028037383

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5405
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
   -2.0155   -6.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0413   -5.4516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7683   -5.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7940   -4.2370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0928   -3.8024    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3658   -4.1923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3400   -5.0169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1186   -2.9778    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4173   -2.5432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4431   -1.7186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7418   -1.2839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0148   -1.6739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6864   -1.2393    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4134   -1.6293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4392   -2.4539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1147   -1.1947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1752   -0.3719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9765   -0.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3664    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9318    1.2530    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.1910    0.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6256   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4502   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8849   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4949   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9295   -2.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6703   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2357   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4111   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8784   -1.5066    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0109   -2.4985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6903   -2.9331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
 28 29  4  0  0  0  0
 18 29  4  0  0  0  0
 29 30  4  0  0  0  0
 16 30  4  0  0  0  0
 12 31  4  0  0  0  0
 31 32  4  0  0  0  0
  9 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5405

>  <JC_XSMILES>
CC1CCN(CC1)CC2=CC=C(NC(=O)C3=CC4=C(Cl)N=C5C=CC(C)=CC5=C4S3)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0451

>  <W2 Pf proliferation inhibition EC50 uM>
0.0649

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>75.83

>  <Powder data?>
Yes

>  <IFI value>
0.081081081

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5406
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5406

>  <JC_XSMILES>
COC1=CN=CC(=C1)C2=CN=CC(=N2)C3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0949

>  <W2 Pf proliferation inhibition EC50 uM>
0.0852

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5408
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1995   -0.5701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7146    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
 10 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 16 22  1  0  0  0  0
 15 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  1  0  0  0  0
 14 31  1  0  0  0  0
 31 32  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5408

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)N(C(C)=O)C2=C(N3CCN(C)CC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0787

>  <W2 Pf proliferation inhibition EC50 uM>
0.01095

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.93

>  <Powder data?>
Yes

>  <IFI value>
0.090909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5409
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5409

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C(C)=CC=CC2=C1NC3=CC=C(C=C3)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1187

>  <W2 Pf proliferation inhibition EC50 uM>
0.0846

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5410
  Mrv1591402191617072D          

 39 44  0  0  0  0            999 V2000
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -0.5422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -0.3707    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -1.9399    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -1.7684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919   -2.3815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8370   -3.1661    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0300   -3.3376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -2.7246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3890   -3.7792    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1341   -4.5638    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6861   -5.1769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4312   -5.9615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6242   -6.1331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0722   -5.5200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3271   -4.7354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    3.1465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    3.9312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    4.5442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    4.3727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  6 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 24 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 31 38  4  0  0  0  0
  5 38  4  0  0  0  0
 38 39  4  0  0  0  0
  2 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5410

>  <JC_XSMILES>
CC1=CC=C2N(CC(O)CN3CCN(CC3)CC4=CC=CC=C4)C(C5=CC=CC=C5)=C(C6=CC=CC=C6)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.824

>  <W2 Pf proliferation inhibition EC50 uM>
0.0845

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035971223

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5412
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
  7 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 20 26  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
  3 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5412

>  <JC_XSMILES>
COC1=CC(CN(CCCN2CCOCC2)C(=O)NC3=CC=CC(C)=C3)=CC=C1OCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.00839

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017699115

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5413
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    2.2374    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 29 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5413

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4=CC=CC(F)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.581

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00837

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028301887

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5414
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
    1.8848   -6.4894    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7053   -6.4032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0408   -5.6495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -4.9820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1902   -7.0706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8546   -7.8243    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3396   -8.4917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0040   -9.2454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4889   -9.9128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1534  -10.6665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3329  -10.7527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8480  -10.0853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1835   -9.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0342   -7.9105    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9479   -7.0900    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1204   -8.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2137   -7.9967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8781   -8.7504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0576   -8.8367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4273   -8.1692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0917   -7.4155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7288   -7.3293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 16 21  4  0  0  0  0
  2 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 23 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  2  0  0  0  0
 31 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5414

>  <JC_XSMILES>
OC(CN1CCC(C1)NC(=O)C2=CC=CC3=CC=CC=C23)CN(CC4=CC=CC=C4)S(=O)(=O)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0825

>  <W2 Pf proliferation inhibition EC50 uM>
<0.0083

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.02970297

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5416
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    3.0467    6.3334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8568    6.1775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3969    6.8011    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1269    5.3979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9370    5.2420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2070    4.4624    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6670    3.8388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8568    3.9947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3167    3.3711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5868    2.5915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5066    3.5270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0172    4.3065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2872    3.5270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7471    2.9033    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0974    3.3711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3674    2.5915    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1568    2.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8632    2.7780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5855    2.3794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6014    1.5545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3237    1.1559    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.8950    1.1283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1727    1.5269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3932    1.2569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0722    0.4969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2536    0.3948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9326   -0.3652    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7559    1.0528    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0768    1.8128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8955    1.9148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 16 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5416

>  <JC_XSMILES>
CC(C)CCN(CCC(C)C)CC(O)CN1C2=CC=C(Cl)C=C2C3=CC(Cl)=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2919

>  <W2 Pf proliferation inhibition EC50 uM>
0.0828

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035087719

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5417
  Mrv1591402191617072D          

 29 31  0  0  1  0            999 V2000
    2.2396    1.0709    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2396    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    2.3084    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.0915    1.7584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0915    1.2084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    0.6584    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.8959    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.3830    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    0.6584    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.5251   -0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -0.5791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -1.8166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0099   -2.6371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7970   -2.8086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2095   -2.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6575   -1.4810    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    0.6584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.8959    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  1  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  0  0  0  0
  3  8  1  0  0  0  0
  8  9  1  1  0  0  0
  9 10  2  0  0  0  0
  1 11  1  1  0  0  0
 11 12  1  1  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 11 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5417

>  <JC_XSMILES>
[H][C@@]1(C[C@@H]2CCN1C[C@@H]2C=C)[C@@H](OC(=O)CC3=CC=CS3)C4=CC=NC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0098

>  <W2 Pf proliferation inhibition EC50 uM>
0.0787

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
95.09

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-542
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
   -8.8337   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8337    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -1.4124    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -0.5874    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  2  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
 35 36  4  0  0  0  0
 27 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-542

>  <JC_XSMILES>
CC1CC(C)CN(C1)S(=O)(=O)C2=CC=C(C=C2)C(=O)NC3=CC=C(C=C3)C4=NC5=CC=C(C)C=C5S4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.319

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.022988506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5422
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
   -3.5723    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -4.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1061   -2.9738    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2376    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0404   -1.3146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.9277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -2.6421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3730   -2.4706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 33 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5422

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC=C4F)C(=O)OC5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0404

>  <W2 Pf proliferation inhibition EC50 uM>
0.01195

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.89

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5426
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 18 26  4  0  0  0  0
 26 27  4  0  0  0  0
 15 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5426

>  <JC_XSMILES>
COC1=CN=CC(=C1)C2=CN=CC(=N2)C3=CC=C(OC4=CC=CC=C4)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0439

>  <W2 Pf proliferation inhibition EC50 uM>
0.0798

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5427
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    1.6710   -0.7910    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6710   -1.6160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3854   -2.0285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3854   -2.8535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6710   -3.2660    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9565   -2.8535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9565   -2.0285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2420   -1.6160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2420   -0.7910    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5013   -0.4330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6849    0.3713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1705    1.0163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6545    1.0163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1689    0.3713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9853   -0.4330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6710   -4.0910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3854   -4.5035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3854   -5.3285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6710   -5.7410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9565   -5.3285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9565   -4.5035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
  9 15  1  0  0  0  0
  5 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5427

>  <JC_XSMILES>
OC1=CC=C(C=C1CN2CCCCCC2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2415

>  <W2 Pf proliferation inhibition EC50 uM>
0.0537

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
67.44

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5428
  Mrv1591402191617072D          

 66 72  0  0  1  0            999 V2000
    9.1070    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6945    3.2704    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8695    3.2704    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.4570    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6320    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2195    3.2704    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.6320    3.9849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4570    3.9849    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.8695    4.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945    3.2704    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820    2.5559    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.3945    1.8414    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.2195    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820    1.1270    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.7573    0.8448    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570    1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445    1.8414    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.9195    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.9195   -1.0164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.2695   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.1715   -0.8070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8205    0.0862    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.3725   -0.5269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1262   -0.1913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0400    0.6292    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.2330    0.8007    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6530    1.1812    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.4600    1.0097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8725    1.7242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3205    2.3373    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.5668    2.0017    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4920    3.1442    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.2766    3.3992    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4482    4.2061    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -5.2131    3.8971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8853    4.9058    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8351    4.7582    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -4.0066    5.5651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0504    4.5032    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.4374    5.0553    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6527    4.8003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8789    3.6963    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.0943    3.4413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.6674    1.3099    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5812    2.1304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.0396    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570    2.5559    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.4574    2.9931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1283    3.3804    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8279    3.8176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8388    0.3145    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.0635    0.0323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4708   -0.2158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2460    0.0664    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3275   -1.0283    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  1  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  6  5  1  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  0  0  0  0
  3  8  1  0  0  0  0
  8  9  1  6  0  0  0
  6 10  1  6  0  0  0
 11 10  1  1  0  0  0
 11 12  1  0  0  0  0
 12 13  1  6  0  0  0
 12 14  1  0  0  0  0
 14 15  1  6  0  0  0
 14 16  1  0  0  0  0
 17 16  1  0  0  0  0
 17 18  1  1  0  0  0
 19 18  1  6  0  0  0
 19 20  1  0  0  0  0
 21 20  1  0  0  0  0
 21 22  1  1  0  0  0
 22 23  1  0  0  0  0
 24 21  1  0  0  0  0
 24 25  1  1  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 19 27  1  0  0  0  0
 26 28  1  1  0  0  0
 29 28  1  0  0  0  0
 29 30  1  1  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 34 33  1  0  0  0  0
 34 35  1  0  0  0  0
 31 35  1  1  0  0  0
 34 36  1  1  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 39 38  1  0  0  0  0
 39 40  1  6  0  0  0
 36 40  1  1  0  0  0
 41 39  1  1  0  0  0
 41 42  1  0  0  0  0
 43 42  1  0  0  0  0
 43 44  1  1  0  0  0
 43 45  1  6  0  0  0
 46 43  1  0  0  0  0
 46 47  1  6  0  0  0
 48 46  1  0  0  0  0
 48 49  1  1  0  0  0
 49 50  1  0  0  0  0
 51 48  1  0  0  0  0
 41 51  1  0  0  0  0
 51 52  1  6  0  0  0
 53 29  1  0  0  0  0
 53 54  1  6  0  0  0
 54 55  1  0  0  0  0
 56 53  1  0  0  0  0
 26 56  1  0  0  0  0
 56 57  1  1  0  0  0
 58 17  1  0  0  0  0
 11 58  1  0  0  0  0
 58 59  1  1  0  0  0
 58 60  1  6  0  0  0
 60 61  1  0  0  0  0
 14 62  1  1  0  0  0
 62 63  1  6  0  0  0
 62 64  1  0  0  0  0
 64 65  1  0  0  0  0
 64 66  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5428

>  <JC_XSMILES>
CO[C@H]1CC[C@@H](O[C@@H]1C)O[C@H]2[C@H](C)[C@](O)(O[C@@H](C[C@@H]3C[C@@H](OC)[C@@H](C)[C@]4(O3)O[C@](C)([C@H]5CC[C@H](O5)[C@H]6CC[C@@H](O6)[C@H]7O[C@](C)(O)[C@H](C)[C@@H](OC)[C@@H]7C)[C@H](OC)[C@H]4C)[C@]2(C)OC)[C@@H](C)C(O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01332

>  <W2 Pf proliferation inhibition EC50 uM>
0.001926

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.422

>  <Powder data?>
No

>  <IFI value>
0.155172414

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5429
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 19 28  4  0  0  0  0
 23 28  4  0  0  0  0
 14 29  4  0  0  0  0
  9 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5429

>  <JC_XSMILES>
COC1=CC=CC(=N1)C2=CC=C(O)C(CNC(C)C3=CC=CC4=CC=CC=C34)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2846

>  <W2 Pf proliferation inhibition EC50 uM>
0.0484

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
61.17

>  <Powder data?>
Yes

>  <IFI value>
0.025641026

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-543
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309    3.8230    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    5.2520    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
  3 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  2  0  0  0  0
 31 33  4  0  0  0  0
 23 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-543

>  <JC_XSMILES>
CCC(N1CCN(CC1)C(=O)NC2=CC=CC=C2C(F)(F)F)C3=NC4=CC=CC=C4C(=O)N3CC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.304

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.020833333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5430
  Mrv1591402191617072D          

 22 24  0  0  1  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
  2 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5430

>  <JC_XSMILES>
C[C@H](NC1=CN=CC(=N1)C2=CC=C(Cl)C=C2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0537

>  <W2 Pf proliferation inhibition EC50 uM>
0.0562

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
71.04

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5435
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    6.4302   -4.5375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.9697    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3197    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 16 25  4  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
  5 29  4  0  0  0  0
 29 30  4  0  0  0  0
  2 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5435

>  <JC_XSMILES>
ClC1=CC=C2C(NCCCCNS(=O)(=O)C3=CC=C4C=CC=CC4=C3)=CC=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2676

>  <W2 Pf proliferation inhibition EC50 uM>
0.00495

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.41

>  <Powder data?>
No

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5437
  Mrv1591402191617072D          

 20 23  0  0  0  0            999 V2000
    0.5143   -1.1166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6172   -0.3136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0748    0.1356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2085    0.9110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0256    1.1394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9312    1.9784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1609    2.2278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4843    2.5864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3662    3.3874    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1901    2.1632    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3043    1.3317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1458    1.3207    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6255    0.6445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4352    0.6481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1489   -0.0403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3323    0.1687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4170   -0.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7541    0.6492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9882   -0.2839    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7009   -0.7358    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
  2 17  1  0  0  0  0
 17 18  1  0  0  0  0
  5 18  1  0  0  0  0
 11 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5437

>  <JC_XSMILES>
CC1CCC2C(C)C(=O)OC3OC(C)C4CC1C23OO4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01906

>  <W2 Pf proliferation inhibition EC50 uM>
0.00762

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-544
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 12 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  4  0  0  0  0
 10 35  4  0  0  0  0
 35 36  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-544

>  <JC_XSMILES>
COC1=CC=C(C=C1Cl)N2N=C(C(=O)NCC(=O)NCCCN3CCOCC3)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.259

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5440
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  1  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
 14 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5440

>  <JC_XSMILES>
C(CC1=CC=CC=C1)NC2=CC=CC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1277

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00752

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5442
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 13 19  4  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 25 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5442

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC(Cl)=C3)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0882

>  <W2 Pf proliferation inhibition EC50 uM>
0.0556

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>74.62

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5443
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 12 21  4  0  0  0  0
 11 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 25  1  0  0  0  0
 22 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 10 31  1  0  0  0  0
  6 31  2  0  0  0  0
 31 32  1  0  0  0  0
  7 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5443

>  <JC_XSMILES>
CCOC(=O)C1C(CC2=C(C(C3=CC=C(OC)C(OC)=C3)C(=C(C)N2)C(=O)OCC)C1=O)C4=CC=CC=C4OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0831

>  <W2 Pf proliferation inhibition EC50 uM>
0.0744

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034883721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5444
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3149   -5.3445    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.1354   -5.4307    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4710   -4.6770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2780   -4.5055    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9918   -4.8246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6044   -4.1538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 19 20  2  0  0  0  0
 16 21  1  0  0  0  0
  8 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5444

>  <JC_XSMILES>
CCOC(=O)C(=O)N1C2=CC=CC=C2c3c(ssc3=S)C1(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0916

>  <W2 Pf proliferation inhibition EC50 uM>
0.0735

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5446
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
   -3.5723    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4850   -2.3175    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -4.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7146   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2376    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0404   -1.3146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.9277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -2.6421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3730   -2.4706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 21 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 34 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5446

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC=C4OC)C(=O)OC5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.212

>  <W2 Pf proliferation inhibition EC50 uM>
0.0728

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5447
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 20 24  4  0  0  0  0
 13 24  4  0  0  0  0
 11 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 10 30  1  0  0  0  0
 27 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5447

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC(Br)=C(OC)C(OCC)=C3)C(=O)C(C(C)C2)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.7

>  <W2 Pf proliferation inhibition EC50 uM>
0.0727

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046511628

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5448
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    2.4920    4.9595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3021    5.1154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8422    4.4918    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5722    3.7123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7620    3.5564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6522    4.6477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1923    4.0240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0024    4.1799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5424    3.5564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2724    2.7768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3525    3.7123    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8926    3.0887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7027    3.2446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9726    4.0240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7828    4.1799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3229    3.5564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1329    3.7123    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.0528    2.7768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2427    2.6209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9726    1.8415    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1626    1.6856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8926    0.9060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0825    0.7502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5424    1.3737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7323    1.2178    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1923    1.8415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8125    2.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6225    2.3092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  4  0  0  0  0
 27 28  4  0  0  0  0
 12 28  4  0  0  0  0
 21 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5448

>  <JC_XSMILES>
CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC3=CC=C(OC)C=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00813

>  <W2 Pf proliferation inhibition EC50 uM>
0.01422

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.61

>  <Powder data?>
Yes

>  <IFI value>
0.069518717

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-545
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0470   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3819   -4.1974    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  4  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  7 11  4  0  0  0  0
  2 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-545

>  <JC_XSMILES>
CC(=NOC(=O)C1=CC=CO1)C2=CN=CC=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.248

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.026315789

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5451
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5159    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    4.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5451

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.52

>  <W2 Pf proliferation inhibition EC50 uM>
<0.0079

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.08

>  <Powder data?>
No

>  <IFI value>
0.027272727

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5453
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674    1.3099    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 10 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
  9 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 22 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5453

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=CS3)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1304

>  <W2 Pf proliferation inhibition EC50 uM>
0.0709

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5455
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -2.5855   -3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480   -2.7770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480   -1.3480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -0.6336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -1.3480    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -3.4914    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -4.2059    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  4  0  0  0  0
  6 21  4  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5455

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N=C2C3=CC=CC=C3OC(=O)C2=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.0705

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5458
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.2822   -0.7752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8125    0.1433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5082    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4372    1.5246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8245    0.8538    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2118    1.5822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7746    2.2819    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0363    1.6110    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4236    2.3394    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2481    2.3682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6354    3.0967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4599    3.1255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8472    3.8539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4101    4.5535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5856    4.5247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1983    3.7963    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  2  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 15 14  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5458

>  <JC_XSMILES>
CC1(C)C2CCC(C2)C1(C)NC(=S)NN=CC3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0348

>  <W2 Pf proliferation inhibition EC50 uM>
0.0382

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
54.71

>  <Powder data?>
Yes

>  <IFI value>
0.25974026

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5464
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 24  1  0  0  0  0
 21 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 10 30  1  0  0  0  0
  6 30  2  0  0  0  0
 30 31  1  0  0  0  0
  7 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 36 39  4  0  0  0  0
 32 39  4  0  0  0  0
M  CHG  2  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5464

>  <JC_XSMILES>
CCOC(=O)C1C(CC2=C(C(C3=CC=C(C=C3)[N+]([O-])=O)C(=C(C)N2)C(=O)OCC)C1=O)C4=CC=CC(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0542

>  <W2 Pf proliferation inhibition EC50 uM>
0.0372

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>54.56

>  <Powder data?>
Yes

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5467
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  6 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  3  0  0  0  0
 22 25  4  0  0  0  0
 25 26  4  0  0  0  0
  4 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
 25 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5467

>  <JC_XSMILES>
CC(C)C1=NC(N2CCN(CC2)C(=O)NC3=CC=CC=C3)=C(C#N)C4=C1COC(C)(C)C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0538

>  <W2 Pf proliferation inhibition EC50 uM>
0.0677

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024096386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5468
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    5.0080    4.8923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1766    4.0847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9603    3.8269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1289    3.0193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5138    2.4695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7301    2.7273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5615    3.5349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6824    1.6619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4832    1.4634    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.8273    0.7136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6509    0.7600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1029    0.0698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7312   -0.6667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9076   -0.7131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4556   -0.0229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6480   -0.1915    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0126    0.3348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2234    0.0944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8739   -0.6529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0520   -0.7239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5795   -0.0475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9290    0.6998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7510    0.7708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2482    1.4291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0079    2.2183    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0279    1.1596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
  8 26  1  0  0  0  0
 17 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5468

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2SC3=CC=CC=C3N=C4C5=CC=CC=C5C(O)=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2491

>  <W2 Pf proliferation inhibition EC50 uM>
0.0464

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
68.61

>  <Powder data?>
Yes

>  <IFI value>
0.02173913

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-547
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 11 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
 23 32  4  0  0  0  0
  8 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-547

>  <JC_XSMILES>
CN(C)CCCNC1=NC=C(C(=O)NCCC2=CC=CC=C2)C(NCC3CCCCC3)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.237

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009708738

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5470
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 10 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5470

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Cl)C=C3)C(=O)CC(C)(C)C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1161

>  <W2 Pf proliferation inhibition EC50 uM>
0.0676

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5471
  Mrv1591402191617072D          

 47 51  0  0  1  0            999 V2000
   -1.8291   -1.5890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3811   -0.9759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1262   -0.1913    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.0400    0.6292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2330    0.8007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8205    0.0862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3725   -0.5269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.1715   -0.8070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.9195    1.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195   -1.0164    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.5070   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445   -1.0164    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.1570   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945   -2.4454    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945   -1.0164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9332   -0.0198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5463   -0.5718    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2607   -0.1593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0892    0.6477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2687    0.7339    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.8562    1.4484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0144   -0.4949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1006   -1.3153    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8543   -1.6509    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -5.3930   -2.3349    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4478   -2.2240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2482   -3.0245    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5218   -1.1660    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -7.2754   -1.5015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4355   -0.3455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6818   -0.0099    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -5.5956    0.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  6  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  3  7  1  0  0  0  0
  8  6  1  0  0  0  0
  8  9  1  6  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  1  0  0  0  0
 14 13  1  0  0  0  0
 14 15  1  1  0  0  0
 16 14  1  0  0  0  0
 16 17  1  6  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 12 19  1  0  0  0  0
 20 18  1  0  0  0  0
 20 21  1  1  0  0  0
 20 22  1  0  0  0  0
 22 23  1  6  0  0  0
 23 24  1  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  2  0  0  0  0
 12 30  1  1  0  0  0
  8 30  1  0  0  0  0
  3 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 35 34  1  0  0  0  0
 35 31  1  0  0  0  0
 35 36  1  1  0  0  0
 33 37  1  0  0  0  0
 37 38  1  0  0  0  0
 39 38  1  0  0  0  0
 39 40  1  1  0  0  0
 39 41  1  6  0  0  0
 41 42  1  0  0  0  0
 39 43  1  0  0  0  0
 43 44  1  1  0  0  0
 43 45  1  0  0  0  0
 46 45  1  0  0  0  0
 46 37  1  0  0  0  0
 46 47  1  1  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5471

>  <JC_XSMILES>
CC[C@@]1(CCC(O1)[C@@]2(C)CC[C@@]3(C[C@@H](O)[C@H](C)C(O3)[C@H](C)[C@H](OC)C(C)C(O)=O)O2)C4OC(C[C@H]4C)C5O[C@](O)(CO)[C@@H](C)C[C@H]5C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.002792

>  <W2 Pf proliferation inhibition EC50 uM>
<0.000868

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.291

>  <Powder data?>
No

>  <IFI value>
0.081967213

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5472
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 13 19  4  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 25 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5472

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC(Br)=C3)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1714

>  <W2 Pf proliferation inhibition EC50 uM>
0.0659

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5477
  Mrv1591402191617072D          

 19 19  0  0  0  0            999 V2000
   -0.5662   -4.8202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1483   -5.2327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8628   -4.8202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5772   -5.2327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2917   -4.8202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0062   -5.2327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7206   -4.8202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4351   -5.2327    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1496   -4.8202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2358   -3.9997    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0428   -3.8282    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.4553   -4.5427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2758   -4.6289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6113   -5.3826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1264   -6.0500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4318   -5.4688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7674   -6.2225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5878   -6.3087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9033   -5.1558    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 12 19  4  0  0  0  0
  9 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5477

>  <JC_XSMILES>
CCCCCCCSC1=NSC(NC(=O)CCC)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.309

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00651

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.036585366

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5478
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2890   -4.3257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8671   -5.1657    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3822   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7177   -6.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2328   -7.2542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5683   -8.0079    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.5877   -7.1680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9232   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4383   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7739   -4.9932    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5478

>  <JC_XSMILES>
COC1=CC=CC(=C1)C2=NOC(=C2)C(=O)NC3=CC(Cl)=CC=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.906

>  <W2 Pf proliferation inhibition EC50 uM>
0.065

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5479
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  2  0  0  0  0
M  CHG  2  29   1  30  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5479

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(=O)CC3C4=CC=C(C=C4)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.346

>  <W2 Pf proliferation inhibition EC50 uM>
0.0649

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-548
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3897   -0.9019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8377   -1.5150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2502   -2.2295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0572   -2.0580    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0714   -1.0799    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5564   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0714    0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  4 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  3  0  0  0  0
 10 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
  2 17  1  0  0  0  0
 13 17  1  0  0  0  0
  3 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-548

>  <JC_XSMILES>
CC1=C(C(C2=CC=CO2)C(C#N)=C3SCCN13)C(=O)OCC=C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.209

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.010638298

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5481
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  2  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5481

>  <JC_XSMILES>
CC1CC(C)CN(C1)C(=O)C2=C(Cl)C3=CC=CC=C3S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0357

>  <W2 Pf proliferation inhibition EC50 uM>
0.0645

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5482
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 11 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 10 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 27 36  4  0  0  0  0
M  CHG  2  19   1  20  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5482

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(C=C3)[N+]([O-])=O)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1803

>  <W2 Pf proliferation inhibition EC50 uM>
0.064

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5484
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    5.0953    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5484

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4=CC=CC=C4F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.951

>  <W2 Pf proliferation inhibition EC50 uM>
0.00635

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5486
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    2.0945    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 11 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 26 29  4  0  0  0  0
 29 30  4  0  0  0  0
 23 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5486

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CSC=C3)C(=O)CC(C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3018

>  <W2 Pf proliferation inhibition EC50 uM>
0.062

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5487
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  2  0  0  0  0
 21 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 35 40  1  0  0  0  0
M  CHG  2  29   1  30  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5487

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=C(C=C4)[N+]([O-])=O)C(=O)OC5CCCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.194

>  <W2 Pf proliferation inhibition EC50 uM>
0.0617

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.048192771

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5489
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   -2.9987    1.1716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4466    0.5585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6397    0.7300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8112    1.5370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8327    0.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4681   -0.0769    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0202   -0.6900    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6077   -1.4045    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007   -1.2330    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 11 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 24 34  4  0  0  0  0
 34 35  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  33
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5489

>  <JC_XSMILES>
CCC(C)(C)N1N=NN=C1C(N2CCN(CC2)C3=CC=CC=C3)C4=CC5=CC=C(C)C=C5NC4=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.453

>  <W2 Pf proliferation inhibition EC50 uM>
0.0614

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.018018018

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-549
  Mrv1591402191617072D          

 25 29  0  0  0  0            999 V2000
    0.0115   -1.8328    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6789   -2.3177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4326   -1.9821    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5189   -1.1617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8514   -0.6767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9377    0.1437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6913    0.4793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9463    1.2639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7713    1.2639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0262    0.4793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7799    0.1437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8661   -0.6767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1987   -1.1617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2725   -0.8261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3588   -0.0056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5927   -3.1382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2602   -3.6231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1739   -4.4436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4202   -4.7791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2472   -4.2942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0009   -4.6298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6683   -4.1449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5821   -3.3244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8284   -2.9888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1610   -3.4737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  4 14  4  0  0  0  0
 14 15  4  0  0  0  0
  7 15  4  0  0  0  0
 10 15  4  0  0  0  0
  2 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 16 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-549

>  <JC_XSMILES>
O=C(NC1=CC=C2CCC3=CC=CC1=C23)C4=CC=CC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.198

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5492
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   19.2907   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 16 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5492

>  <JC_XSMILES>
CCCCCCCC(=O)N(C)CCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2422

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00587

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>9.69

>  <Powder data?>
No

>  <IFI value>
0.063157895

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5493
  Mrv1591402191617072D          

 29 30  0  0  1  0            999 V2000
   -2.9114   -3.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1969   -3.0012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4824   -3.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7680   -3.0012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0535   -3.4137    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6610   -3.0012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6610   -2.1762    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3755   -3.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3755   -4.2387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0899   -4.6512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0899   -5.4762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0899   -3.0012    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0283   -2.1785    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.2603   -1.8771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6330   -1.6173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3899   -0.8290    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4488   -1.7403    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8613   -2.4548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6771   -2.3318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1915   -2.9768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8901   -3.7448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4045   -4.3898    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1031   -5.1578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6174   -5.8028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2873   -5.2807    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0743   -3.8677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5599   -3.2227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7716   -3.4659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6486   -4.2817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  8 12  1  0  0  0  0
 13 12  1  0  0  0  0
 13 14  1  1  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 27 28  1  0  0  0  0
 12 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5493

>  <JC_XSMILES>
CCCCNC(=O)C(\C=C\C)N1[C@@H](C)C(=O)NC2=CC=C(NC(C)=O)C=C2C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1988

>  <W2 Pf proliferation inhibition EC50 uM>
0.00457

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.59

>  <Powder data?>
No

>  <IFI value>
0.012345679

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5494
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5494

>  <JC_XSMILES>
CC(C)OC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3Cl)C(=O)CC(C2)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2969

>  <W2 Pf proliferation inhibition EC50 uM>
0.0384

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>64.23

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5495
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 13 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 12 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  4  0  0  0  0
 27 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5495

>  <JC_XSMILES>
COCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(F)C=C3)C(=O)CC(C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.161

>  <W2 Pf proliferation inhibition EC50 uM>
0.059

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034482759

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5496
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0650   -1.1029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0162   -0.2164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7681   -0.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4380   -0.0745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3561    0.7464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6041    1.0859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0658    0.6044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  1  0  0  0  0
  3 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  7 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
M  CHG  2  21   1  22  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5496

>  <JC_XSMILES>
CCN1C2=CC=C(C=C2N(CC)C1(C)C3=CC=CC=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2039

>  <W2 Pf proliferation inhibition EC50 uM>
0.0397

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
67.64

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5497
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 12 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 11 27  1  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 34 37  4  0  0  0  0
 28 37  4  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5497

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC(=C3)[N+]([O-])=O)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1448

>  <W2 Pf proliferation inhibition EC50 uM>
0.0364

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>62.37

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5498
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -4.2869    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 13 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 12 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5498

>  <JC_XSMILES>
CCC(C)OC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3F)C(=O)CC(C2)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2052

>  <W2 Pf proliferation inhibition EC50 uM>
0.0583

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024096386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5499
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    0.3544   -4.6019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0688   -5.0144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0688   -5.8394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7833   -4.6019    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4978   -5.0144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2123   -4.6019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9267   -5.0144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6412   -4.6019    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3557   -5.0144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4419   -5.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2489   -6.0064    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6614   -5.2919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1093   -4.6788    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.4819   -5.2057    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.3956   -4.3852    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5681   -6.0261    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3023   -5.1194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6379   -4.3657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4584   -4.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9433   -4.9470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6077   -5.7006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7873   -5.7869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8288   -6.3869    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.2157   -6.9389    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2768   -5.7738    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3808   -7.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1878   -6.8284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7398   -7.4415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4849   -8.2262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0369   -8.8392    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.6779   -8.3977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1259   -7.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 10 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5499

>  <JC_XSMILES>
CC(C)OCCCNC1=C(N=C(S1)S(=O)(=O)C2=CC=CC=C2)S(=O)(=O)C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0941

>  <W2 Pf proliferation inhibition EC50 uM>
0.0581

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5500
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
  9 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
  8 24  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5500

>  <JC_XSMILES>
CC1CCN(CC1)C2=C(NC3CCCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00908

>  <W2 Pf proliferation inhibition EC50 uM>
0.01418

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
24.42

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5502
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -2.3215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4010   -3.1230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1496   -3.4698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8874   -3.1008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0590   -2.2938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5350   -1.6566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7101   -1.6689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8010   -2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6260   -0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -2.7604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
  4 14  4  0  0  0  0
 14 15  4  0  0  0  0
  2 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 25 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5502

>  <JC_XSMILES>
CN1N=C(C(=O)N2CCCCCC2)C3=C1CCC(C3)NCC(C)(C)N4CCOCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02249

>  <W2 Pf proliferation inhibition EC50 uM>
0.00552

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>9.56

>  <Powder data?>
No

>  <IFI value>
0.012048193

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5504
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 13 19  4  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 25 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5504

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC(C)=C3)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2363

>  <W2 Pf proliferation inhibition EC50 uM>
0.0572

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.0875

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5505
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5505

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=C(F)C=C4)C(=O)OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00945

>  <W2 Pf proliferation inhibition EC50 uM>
0.01305

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
22.83

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5507
  Mrv1591402191617072D          

 20 19  0  0  0  0            999 V2000
    5.3625    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5375    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5375    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5375    1.3184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7125    2.1434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3000    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7125    0.7145    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750    1.4289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0625    0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -1.4289    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -2.1434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.8579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.5724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  9  8  1  0  0  0  0
  9 10  2  0  0  0  0
 11 10  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5507

>  <JC_XSMILES>
CC(C)(C)NC(=S)NN=CC=NNC(=S)NC(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.21

>  <W2 Pf proliferation inhibition EC50 uM>
0.0569

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047244094

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5510
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
   -5.5723   -3.3400    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8578   -2.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8578   -2.1025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1434   -1.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4289   -2.1025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4289   -2.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1434   -3.3400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7144   -1.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6282   -0.8695    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9607   -2.0255    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
 13 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 25 26  4  0  0  0  0
 17 26  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  26
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5510

>  <JC_XSMILES>
NC1=CC=C(C=C1)C2=NC3=CC=C(C=C3N2)C4=NC5=CC=C(N)C=C5N4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1196

>  <W2 Pf proliferation inhibition EC50 uM>
0.0556

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.025641026

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5511
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -1.3144    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 10 24  1  0  0  0  0
 19 24  4  0  0  0  0
 11 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
  6 30  4  0  0  0  0
 30 31  4  0  0  0  0
  3 31  4  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5511

>  <JC_XSMILES>
COC1=CC=C(NC(=O)C2C(N(CC(C)C)C(=O)C3=CC=CC=C23)C4=CC=CS4)C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0914

>  <W2 Pf proliferation inhibition EC50 uM>
0.0556

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5512
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4257   -5.3493    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.9106   -6.0167    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.6052   -5.4355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  2 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  2  0  0  0  0
 13 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
M  CHG  2  23   1  24  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5512

>  <JC_XSMILES>
CC(CCC1=CC=CC=C1)N2CC(OC2=S)C3=CC=CC(=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3069

>  <W2 Pf proliferation inhibition EC50 uM>
0.01799

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
32.84

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5513
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  4  0  0  0  0
 24 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5513

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=C(F)C=C3)C(=O)CC(C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1909

>  <W2 Pf proliferation inhibition EC50 uM>
0.0547

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023255814

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5514
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489    0.8152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227    1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    1.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175    3.0199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483    2.5100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 12 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
 28 29  4  0  0  0  0
 11 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5514

>  <JC_XSMILES>
CC(=O)OC1=CC=CC=C1C2=C(NC(C)(C)CC(C)(C)C)N3C=CC(C)=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.389

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00533

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.046728972

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5515
  Mrv1591402191617072D          

 36 41  0  0  0  0            999 V2000
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2487    3.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007    4.2631    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3882    4.9775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7238    5.7312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5442    5.8174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8798    6.5711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3949    7.2386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5744    7.1523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2388    6.3986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4188    4.8060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0319    5.3580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8603    6.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4734    6.7170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2580    6.4621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4296    5.6551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8165    5.1031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  7 14  4  0  0  0  0
  4 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  2 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 22 36  4  0  0  0  0
 30 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5515

>  <JC_XSMILES>
OC(CN1C=NC(C2=CC=CC=C2)=C1C3=CC=CC=C3)CN4C5=CC=C(Br)C=C5C6=CC(Br)=CC=C46

>  <PF proliferation inhibition 3D7 EC50 uM>
0.952

>  <W2 Pf proliferation inhibition EC50 uM>
0.0532

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.007194245

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5518
  Mrv1591402191617072D          

 16 16  0  0  0  0            999 V2000
   -0.7145    4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  5  4  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
M  CHG  2  14   1  15  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5518

>  <JC_XSMILES>
NC(=S)NN=CC1=CC(=CC=C1O)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0686

>  <W2 Pf proliferation inhibition EC50 uM>
0.052

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5519
  Mrv1591402191617072D          

 33 35  0  0  1  0            999 V2000
    1.1537    3.4130    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3857    3.1116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2628    2.2958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5052    1.9944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6281    1.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3961    0.8772    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.4578    0.0545    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7433   -0.3580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0288    0.0545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0288    0.8795    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6856   -0.3580    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4001    0.0545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1146   -0.3580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8291    0.0545    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1146   -1.1830    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7433   -1.1830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0288   -1.5955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0288   -2.4205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7433   -2.8330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4578   -2.4205    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4578   -1.5955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1394   -0.4102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0165   -1.2260    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9278   -0.1670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4421   -0.8120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2579   -0.6891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7723   -1.3341    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5593    0.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0450    0.7239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2292    0.6010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8167    1.3154    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0009    1.4384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7577    2.2267    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  6  5  1  6  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
  8 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  7 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
  6 32  1  0  0  0  0
 32 33  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5519

>  <JC_XSMILES>
NCCCC[C@@H]1N(C(C(=O)NCC(O)=O)C2=CC=CN=C2)C(=O)C3=CC(O)=CC=C3NC1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1154

>  <W2 Pf proliferation inhibition EC50 uM>
<0.0063

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>12.12

>  <Powder data?>
No

>  <IFI value>
0.011764706

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-552
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 11 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
  7 27  4  0  0  0  0
 27 28  4  0  0  0  0
  4 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-552

>  <JC_XSMILES>
CCOC1=CC=C(NC2=NC(=NC(=N2)N3CCCCC3)N4CCCCC4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.187

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5521
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5521

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Cl)C=C3)C(=O)CC(C2)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0894

>  <W2 Pf proliferation inhibition EC50 uM>
0.0515

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5522
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 12 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 11 27  1  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 34 35  4  0  0  0  0
 28 35  4  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5522

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(C=C3)[N+]([O-])=O)C(=O)CC(C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.281

>  <W2 Pf proliferation inhibition EC50 uM>
0.0514

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5524
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435    1.9817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0025    2.4233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5546    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3615    2.8649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6165    2.0803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0645    1.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4515    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2585    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8105    1.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5556    1.9087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7486    2.0803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1966    1.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  2  0  0  0  0
  8 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  7 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 18 30  4  0  0  0  0
  6 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5524

>  <JC_XSMILES>
CCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)C4=C(CN(CC4)CC5=CC=CC=C5)S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0858

>  <W2 Pf proliferation inhibition EC50 uM>
0.0348

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>68.36

>  <Powder data?>
Yes

>  <IFI value>
0.028368794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5527
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    5.0594   -4.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4719   -3.8855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0594   -3.1711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4719   -2.4566    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2969   -2.4566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7094   -1.7421    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7094   -3.1711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2969   -3.8855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5344   -3.1711    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9469   -3.8855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7719   -3.8855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1844   -4.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7719   -5.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1844   -6.0289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7719   -6.7434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2862   -7.3884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1027   -8.1927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3594   -8.5507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6161   -8.1927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4325   -7.3884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9469   -6.7434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5344   -6.0289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7094   -6.0289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9469   -5.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5344   -4.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0594   -1.7421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2344   -1.7421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8219   -1.0276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2344   -0.3132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8219    0.4013    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2344    1.1158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8219    1.8302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0594   -0.3132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4719   -1.0276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 15 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
 13 24  4  0  0  0  0
 24 25  4  0  0  0  0
 10 25  4  0  0  0  0
  4 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 29 33  4  0  0  0  0
 33 34  4  0  0  0  0
 26 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5527

>  <JC_XSMILES>
CCCN(C(=O)C(=O)NC1=CC=C2N=C3CCCCCN3C(=O)C2=C1)C4=CC=C(OCC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0899

>  <W2 Pf proliferation inhibition EC50 uM>
0.0501

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5528
  Mrv1591402191617072D          

 27 31  0  0  0  0            999 V2000
    4.4243   -5.3708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7098   -4.9583    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9953   -5.3709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9954   -6.1959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2809   -6.6084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5664   -6.1960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5664   -5.3710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2808   -4.9584    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8519   -4.9585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1374   -5.3710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.9586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.1336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2916   -3.7211    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -3.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -2.8960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -2.4835    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -1.6585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -1.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5873   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -0.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8518   -4.1335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
 20 21  1  0  0  0  0
 19 24  1  0  0  0  0
 17 25  1  0  0  0  0
 23 24  1  0  0  0  0
 21 26  1  0  0  0  0
 23 25  1  0  0  0  0
 22 23  1  0  0  0  0
 17 26  1  0  0  0  0
 19 20  1  0  0  0  0
 14 27  4  0  0  0  0
  9 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5528

>  <JC_XSMILES>
COC1=CC=CC(=N1)C2=CC=C(O)C(CNC34CC5CC(CC(C5)C3)C4)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2067

>  <W2 Pf proliferation inhibition EC50 uM>
0.05

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034482759

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5529
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 12 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 24 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5529

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=CC(O)=C3)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.092

>  <W2 Pf proliferation inhibition EC50 uM>
0.05

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-553
  Mrv1591402191617072D          

 17 17  0  0  0  0            999 V2000
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559    0.3020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309   -1.1270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  9 17  4  0  0  0  0
  5 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-553

>  <JC_XSMILES>
CC(=O)NC1=CC=CC(NC(=O)C(F)(F)F)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.185

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.047619048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5531
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9139    0.6674    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5531

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3OC)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0741

>  <W2 Pf proliferation inhibition EC50 uM>
0.0492

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023255814

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5532
  Mrv1591402191617072D          

 24 25  0  0  1  0            999 V2000
    3.6685   -1.0709    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.6685   -0.2459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    0.1666    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.5205   -0.3834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5205   -0.9334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830   -1.4834    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975   -0.2459    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.8119    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5264   -0.2459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -1.4834    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.2396   -1.0709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -2.7209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -3.9584    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -3.9584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -2.7209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -2.3084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  1  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  0  0  0  0
  3  8  1  0  0  0  0
  8  9  1  1  0  0  0
  9 10  1  0  0  0  0
  1 11  1  6  0  0  0
 11 12  1  1  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 20 24  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5532

>  <JC_XSMILES>
[H][C@]1(C[C@@H]2CCN1C[C@@H]2CC)[C@H](O)C3=CC=NC4=CC=C(OCC)C=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0318

>  <W2 Pf proliferation inhibition EC50 uM>
0.02573

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
53.82

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5533
  Mrv1591402191617072D          

 43 47  0  0  0  0            999 V2000
   -0.1508    3.3519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6719    3.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0299    2.5469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8526    2.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2105    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0332    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4980    2.3620    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3912    0.9370    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2162    0.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5741    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1094    2.3620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4673    3.1053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2900    3.1669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7548    2.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3968    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6480    3.9102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0059    4.6535    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.3913    3.5522    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.9047    4.2682    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.7305    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5470   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1517   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9401   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1237   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5189    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7025    1.3395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5448   -1.3914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3332   -1.1483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9380   -1.7094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7544   -2.5137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3592   -3.0749    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1475   -2.8317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9660   -2.7569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7825   -3.5612    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9941   -3.8044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3613   -2.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8037   -0.8703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0604   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4556   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6673   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4837   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0884    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8768    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
  9 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 25 26  2  0  0  0  0
 23 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 27 36  4  0  0  0  0
 21 37  2  0  0  0  0
 37 38  1  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
  8 43  1  0  0  0  0
 38 43  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5533

>  <JC_XSMILES>
CCCCCC(=O)N1C(C2=CC=C(C=C2)C(F)(F)F)C3=C(CC(CC3=O)C4=CC=C(OC)C(OC)=C4)NC5=CC=CC=C15

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1072

>  <W2 Pf proliferation inhibition EC50 uM>
0.047

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.033707865

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5534
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5534

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Br)C=C3)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0377

>  <W2 Pf proliferation inhibition EC50 uM>
0.0469

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.048780488

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5536
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    4.8229    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 12 19  4  0  0  0  0
 10 20  4  0  0  0  0
  2 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5536

>  <JC_XSMILES>
CC1=NC2=NC(C)=NN2C(NC3=CC=C(Br)C(C)=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.053

>  <W2 Pf proliferation inhibition EC50 uM>
0.0458

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5537
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760    2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309    3.3320    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0408    3.9995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    0.8205    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 11 16  4  0  0  0  0
  7 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
  5 23  1  0  0  0  0
 23 24  2  0  0  0  0
  6 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5537

>  <JC_XSMILES>
CC(C)CN1C(C(C(=O)NC2=NOC(C)=C2)C3=CC=CC=C3C1=O)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0856

>  <W2 Pf proliferation inhibition EC50 uM>
0.0453

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5539
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -0.9355   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2211   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2211   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355    0.4125    0.0000 B   0  5  0  0  0  0  0  0  0  0  0  0
   -0.9355    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2211    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2211    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7605    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9980   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4105    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9980    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  4  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  1  6  4  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  7 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
  7 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  CHG  1   7  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5539

>  <JC_XSMILES>
C1=CC=C(C=C1)[B-](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1236

>  <W2 Pf proliferation inhibition EC50 uM>
0.0448

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012658228

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-554
  Mrv1591402191617072D          

 28 29  0  0  0  0            999 V2000
    4.7289   -7.2039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9039   -7.2039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4914   -6.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664   -6.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -6.4895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -5.0605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1914   -5.0605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2211   -4.3461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1914   -3.6316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.6316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.3461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2211   -2.9171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0461   -2.9171    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4586   -2.2026    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7441   -1.7901    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730   -2.6151    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8711   -1.4882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6961   -1.4882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1086   -0.7737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6961   -0.0592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1086    0.6552    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9336    0.6552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8711   -0.0592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4586   -0.7737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9039   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 25 26  4  0  0  0  0
 19 26  4  0  0  0  0
  3 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-554

>  <JC_XSMILES>
COC(CNC(=O)C1CCC(CC1)CNS(=O)(=O)C2=CC=C(OC)C=C2)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.185

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.02173913

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5540
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -4.2869    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5540

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3Cl)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0662

>  <W2 Pf proliferation inhibition EC50 uM>
0.0448

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5541
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5152    3.2955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3221    3.4670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7346    2.7525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1826    2.1394    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 11 13  1  0  0  0  0
  7 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 22 26  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5541

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1NC2CC2)N3CCN(CC3)C(=O)C4=CC=CO4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1004

>  <W2 Pf proliferation inhibition EC50 uM>
0.0445

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012048193

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5542
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  6 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 11 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5542

>  <JC_XSMILES>
CCOC(=O)C1=C(CC)NC2=C(C1C3=CC=C(Br)C=C3)C(=O)CC(C)(C)C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.408

>  <W2 Pf proliferation inhibition EC50 uM>
0.0441

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5543
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 13 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 12 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5543

>  <JC_XSMILES>
CCC(C)OC(=O)C1=C(C)NC2=C(C1C3=CC=C(Cl)C=C3)C(=O)CC(C2)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2164

>  <W2 Pf proliferation inhibition EC50 uM>
0.0438

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5545
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5545

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(F)C=C3)C(=O)CC(C2)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.095

>  <W2 Pf proliferation inhibition EC50 uM>
0.0428

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034883721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5546
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 16 22  1  0  0  0  0
 19 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
 11 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5546

>  <JC_XSMILES>
CC(C)OC(=O)C1=C(C)N=C(N=C1C(=O)N2CCN(C(C)C2)C(=O)NC3CCCCC3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0844

>  <W2 Pf proliferation inhibition EC50 uM>
0.0417

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.028301887

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5547
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -1.3144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
  9 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 19 20  1  0  0  0  0
 13 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 19 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 31 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5547

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=C(F)C=C4)C(=O)OC5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0986

>  <W2 Pf proliferation inhibition EC50 uM>
0.0416

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034883721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5549
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -1.4534   -0.6979    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -3.5854    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2451   -3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8951   -3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  4  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  5 21  4  0  0  0  0
  2 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5549

>  <JC_XSMILES>
ClC1=CC2=C(CCCC2=NOS(=O)(=O)C3=CC=CC=C3)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1576

>  <W2 Pf proliferation inhibition EC50 uM>
0.0409

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.02238806

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-555
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
  3 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-555

>  <JC_XSMILES>
COC1=CC=C(CN2CC(=O)N(C2=S)C3=CC=C(Cl)C=C3)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.183

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5550
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5550

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3Cl)C(=O)CC(C2)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0442

>  <W2 Pf proliferation inhibition EC50 uM>
0.0408

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.032258065

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5551
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 13 23  4  0  0  0  0
 11 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 10 29  1  0  0  0  0
 26 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5551

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC(Br)=C(OC)C(OC)=C3)C(=O)C(C(C)C2)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.537

>  <W2 Pf proliferation inhibition EC50 uM>
0.0404

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5552
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -3.5723    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4850   -2.3175    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -4.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7146   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2376    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0012   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 21 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5552

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC=C4OC)C(=O)OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0919

>  <W2 Pf proliferation inhibition EC50 uM>
0.0398

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034883721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5553
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 17 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
 13 24  4  0  0  0  0
 11 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 10 30  1  0  0  0  0
 27 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5553

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC(Br)=C(OCC)C(OC)=C3)C(=O)C(C(C)C2)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2553

>  <W2 Pf proliferation inhibition EC50 uM>
0.0396

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.058139535

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5556
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    1.1525   -1.8050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1525   -2.6300    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4380   -3.0425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2764   -2.6300    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4380   -3.8675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1055   -4.3524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8901   -4.0975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8505   -5.1370    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0255   -5.1370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4594   -5.8045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2799   -5.7182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8319   -6.3313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6604   -7.1383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5856   -5.9958    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4993   -5.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1124   -4.6233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6924   -5.0038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3000   -6.4083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3000   -7.2333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0145   -7.6458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7290   -7.2333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7290   -6.4083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0145   -5.9958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0145   -5.1708    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2294   -4.3524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0140   -4.0975    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 11 17  4  0  0  0  0
 14 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
  9 25  1  0  0  0  0
  5 25  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5556

>  <JC_XSMILES>
COC(=O)C1=C(C)NC(=CC2=C(C)N(C(C)=C2)C3=CC=CC=C3F)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02

>  <W2 Pf proliferation inhibition EC50 uM>
0.0383

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5562
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3149   -5.3445    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.1354   -5.4307    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4710   -4.6770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2780   -4.5055    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9918   -4.8246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6044   -4.1538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 20 21  2  0  0  0  0
 17 22  1  0  0  0  0
  8 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5562

>  <JC_XSMILES>
CCOC(=O)C(=O)N1C2=CC=C(C)C=C2C3=C(SSC3=S)C1(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0465

>  <W2 Pf proliferation inhibition EC50 uM>
0.0377

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5563
  Mrv1591402191617072D          

 32 37  0  0  0  0            999 V2000
   -0.8409    5.2171    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0571    4.9597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5578    5.5098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3416    5.2524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5106    4.4449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2944    4.1874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4633    3.3799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2472    3.1225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4161    2.3150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8013    1.7649    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0175    2.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8485    2.8298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9703    0.9574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7541    0.7000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4698    1.1102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0812    0.5562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7432   -0.1964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9230   -0.1075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3082   -0.6576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4772   -1.4651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6461   -2.2727    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5244   -0.4002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8086   -0.8104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1973   -0.2565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3765   -0.3401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1063    0.3289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2317    1.0815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0524    1.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5352    0.4961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3554    0.4073    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8957    3.8948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1119    4.1522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  3  0  0  0  0
 19 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 13 30  4  0  0  0  0
 22 30  4  0  0  0  0
  5 31  4  0  0  0  0
 31 32  4  0  0  0  0
  2 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5563

>  <JC_XSMILES>
FC1=CC=C(CN2CCN(CC2)C3=C4CCCC4=C(C#N)C5=NC6=CC=CC=C6N35)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01981

>  <W2 Pf proliferation inhibition EC50 uM>
0.0377

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5564
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -1.3144    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  1  0  0  0  0
 20 25  4  0  0  0  0
 12 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
  7 31  4  0  0  0  0
 31 32  4  0  0  0  0
  4 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5564

>  <JC_XSMILES>
CCOC1=CC=C(NC(=O)C2C(N(CC(C)C)C(=O)C3=CC=CC=C23)C4=CC=CS4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0783

>  <W2 Pf proliferation inhibition EC50 uM>
0.0367

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5567
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
  7 19  4  0  0  0  0
  2 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5567

>  <JC_XSMILES>
CC1=CC(C)=NC(NC(=N)NC2=CC=CC=C2O)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.379

>  <W2 Pf proliferation inhibition EC50 uM>
0.0362

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5568
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
  5 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5568

>  <JC_XSMILES>
OC1=CC=C(C=C1CNC2CCCCC2)C3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0402

>  <W2 Pf proliferation inhibition EC50 uM>
0.00628

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.4

>  <Powder data?>
Yes

>  <IFI value>
0.017391304

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-557
  Mrv1591402191617072D          

 27 30  0  0  1  0            999 V2000
    9.8538    4.1855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3689    3.5180    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5484    3.6043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0635    2.9368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2430    3.0231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9074    3.7767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3923    4.4442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2128    4.3579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0869    3.8630    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.5349    3.2499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8675    4.4059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2544    4.9580    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6744    4.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0100    5.3311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  9  6  1  6  0  0  0
  9 10  1  0  0  0  0
 11 10  1  0  0  0  0
 11 12  1  6  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
 11 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
  9 26  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-557

>  <JC_XSMILES>
COC1=CC=C(C=C1)[C@@H]2C[C@H](OC(=O)C3=CC=C4OCOC4=C3)C(=O)N2C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.175

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5572
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 23 29  4  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5572

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC(C)=C4)C(=O)OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0821

>  <W2 Pf proliferation inhibition EC50 uM>
0.01915

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
54.83

>  <Powder data?>
Yes

>  <IFI value>
0.060240964

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5573
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5573

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3Cl)C(=O)CC(C2)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2513

>  <W2 Pf proliferation inhibition EC50 uM>
0.0349

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.05952381

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5575
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
   -3.5723    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -4.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -4.9501    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1061   -2.9738    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2376    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0404   -1.3146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.9277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -2.6421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3730   -2.4706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
  9 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 19 20  1  0  0  0  0
 13 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 27 28  1  0  0  0  0
 19 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 32 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5575

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=C(Cl)C=C4Cl)C(=O)OC5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1256

>  <W2 Pf proliferation inhibition EC50 uM>
0.0347

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5577
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -3.5723    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -4.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1061   -2.9738    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2376    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0012   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5577

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC=C4Br)C(=O)OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01369

>  <W2 Pf proliferation inhibition EC50 uM>
0.00784

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.34

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5578
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -1.3144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
  9 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 19 20  1  0  0  0  0
 13 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 19 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 30 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5578

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC=C4)C(=O)OC5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1242

>  <W2 Pf proliferation inhibition EC50 uM>
0.0335

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.058139535

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5579
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 13 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 12 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  4  0  0  0  0
 27 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5579

>  <JC_XSMILES>
COCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Cl)C=C3)C(=O)CC(C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1673

>  <W2 Pf proliferation inhibition EC50 uM>
0.0332

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046511628

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5580
  Mrv1591402191617072D          

 20 23  0  0  0  0            999 V2000
    4.2673   -0.8918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6051   -0.4544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9132   -0.8692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3711   -0.2732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4635    0.5492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6626    0.7731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1235    0.1905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3850    1.5332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6322    1.7847    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0633    1.9734    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8472    1.7131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445    1.5007    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5449    1.7057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2043    2.1473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0122    1.0344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5420    0.3715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7170    0.3608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1777    1.0297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4073    1.9444    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1058    2.3873    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
  2 17  1  0  0  0  0
 17 18  1  0  0  0  0
  5 18  1  0  0  0  0
 11 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 13 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5580

>  <JC_XSMILES>
CC1CCC2C(C)C(O)OC3OC4(C)CCC1C23OO4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00705

>  <W2 Pf proliferation inhibition EC50 uM>
0.00331

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.075471698

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5583
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  4  0  0  0  0
 26 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5583

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC(F)=C3)C(=O)CC(C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0724

>  <W2 Pf proliferation inhibition EC50 uM>
0.0329

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5584
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
   10.7171  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894  -12.3750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
  2 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 30 33  1  0  0  0  0
 33 34  2  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 33 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5584

>  <JC_XSMILES>
O=C(NCCCCCCNC(=O)NC1=CC=C(C=C1)C2=NCCCN2)NC3=CC=C(C=C3)C4=NCCCN4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1082

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00328

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.054054054

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5585
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -3.5723   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1060   -2.8013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 13 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 12 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 27 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5585

>  <JC_XSMILES>
COCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3C)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1095

>  <W2 Pf proliferation inhibition EC50 uM>
0.0323

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.075949367

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5586
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5586

>  <JC_XSMILES>
CCC1=NC(N)=NC(N)=C1C2=CC=C(Cl)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0319

>  <W2 Pf proliferation inhibition EC50 uM>
0.01456

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
45.62

>  <Powder data?>
Yes

>  <IFI value>
0.041176471

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5591
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 13 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 12 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  4  0  0  0  0
 27 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5591

>  <JC_XSMILES>
CCC(C)OC(=O)C1=C(C)NC2=C(C1C3=CC=C(O)C=C3)C(=O)CC(C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.03119

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5592
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -4.2869    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 11 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  4  0  0  0  0
 27 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5592

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC(Cl)=C3Cl)C(=O)CC(C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2333

>  <W2 Pf proliferation inhibition EC50 uM>
0.03084

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5594
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 24 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5594

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3F)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0505

>  <W2 Pf proliferation inhibition EC50 uM>
0.03056

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047619048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5595
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  1  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5595

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC(Cl)=C3Cl)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0329

>  <W2 Pf proliferation inhibition EC50 uM>
0.03052

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5598
  Mrv1591402191617072D          

 38 43  0  0  0  0            999 V2000
    7.3178   -4.6155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5499   -4.9170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3423   -5.7154    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5188   -5.7648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0746   -6.4600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2174   -4.9968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8546   -4.4728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8053   -3.6493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4938   -3.1948    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0674   -3.2803    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4148   -3.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6133   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2665   -2.8408    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6355   -2.1029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -1.4898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2765   -1.6613    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7245   -1.0482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9175   -1.2198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3655   -0.6067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4415   -0.7782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9935   -0.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7386    0.6195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0684    0.7910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6204    0.1779    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3385   -0.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1454   -0.5337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6975   -1.1468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4425   -1.9314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0798   -2.4553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4004    0.2510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9154    0.9184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4004    1.5858    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1850    1.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    1.7434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6139    1.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6139    0.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    0.0934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1850    0.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 15 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 14 28  4  0  0  0  0
 28 29  1  0  0  0  0
 10 29  1  0  0  0  0
 26 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 30 38  4  0  0  0  0
 33 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5598

>  <JC_XSMILES>
CN1N=C(C)C=C1C(=O)N2CCOC3=C(OCCC4=CC=CC=N4)C=C(C=C3C2)C5=CSC6=CC=CC=C56

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0325

>  <W2 Pf proliferation inhibition EC50 uM>
0.01394

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
46.88

>  <Powder data?>
Yes

>  <IFI value>
0.019230769

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5599
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -0.9404   -3.1102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6549   -3.5227    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6549   -4.3477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9404   -4.7602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9404   -5.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6549   -5.9977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6549   -6.8227    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3693   -7.2352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3693   -5.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3693   -4.7602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0838   -5.9977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0838   -6.8227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7983   -7.2352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5127   -6.8227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2272   -7.2352    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5127   -5.9977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2272   -5.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2272   -4.7602    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9417   -4.3477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9417   -3.5227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2239   -2.7474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6936   -2.1154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8811   -2.2587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5989   -3.0340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1292   -3.6659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7542   -3.6659    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0363   -4.4412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8488   -4.5844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3791   -3.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0969   -3.1772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2845   -3.0340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7983   -5.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 20 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
 16 32  4  0  0  0  0
 11 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5599

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CNCC3(CCCCC3)N4CCCCC4)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0437

>  <W2 Pf proliferation inhibition EC50 uM>
0.0113

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
38.04

>  <Powder data?>
Yes

>  <IFI value>
0.008849558

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5602
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  3  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 19 34  4  0  0  0  0
 34 35  2  0  0  0  0
 34 36  4  0  0  0  0
 16 36  4  0  0  0  0
 36 37  4  0  0  0  0
 13 37  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5602

>  <JC_XSMILES>
CN(C1=CC=C(Br)C=C1)S(=O)(=O)C2=CC=C3NC=C(C(=O)N4CCN(CC4)C5=CC=CC=C5)C(=O)C3=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
<0.002831

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.051282051

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5603
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 25 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5603

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3C)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1344

>  <W2 Pf proliferation inhibition EC50 uM>
0.02745

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5605
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  4  0  0  0  0
 25 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5605

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3F)C(=O)CC(C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0741

>  <W2 Pf proliferation inhibition EC50 uM>
0.02706

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034883721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5607
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  4  0  0  0  0
 18 27  4  0  0  0  0
 13 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 11 31  4  0  0  0  0
 31 32  4  0  0  0  0
  6 32  4  0  0  0  0
 32 33  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5607

>  <JC_XSMILES>
CCOC(=O)C1=CN(CC)C2=CC(N(C)CCC3=CC=C(OC)C(OC)=C3)=C(F)C=C2C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1031

>  <W2 Pf proliferation inhibition EC50 uM>
0.02674

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046875

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5608
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 25 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5608

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3Br)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0732

>  <W2 Pf proliferation inhibition EC50 uM>
0.02671

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5609
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 25 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5609

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3F)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02758

>  <W2 Pf proliferation inhibition EC50 uM>
0.02642

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5611
  Mrv1591402191617072D          

 16 18  0  0  0  0            999 V2000
    2.0329   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  4  0  0  0  0
  5 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5611

>  <JC_XSMILES>
CC1=CC=C2C=CC3=CC=C(C)N=C3C2=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0971

>  <W2 Pf proliferation inhibition EC50 uM>
0.02434

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.171428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5615
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
  9 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 19 20  1  0  0  0  0
 13 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 19 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5615

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=C(F)C=C4)C(=O)OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0834

>  <W2 Pf proliferation inhibition EC50 uM>
0.02315

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034883721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5616
  Mrv1591402191617072D          

 27 31  0  0  0  0            999 V2000
   -5.3745    4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6600    3.9464    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9455    4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9455    5.1839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2311    5.5964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5166    5.1839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5166    4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2311    3.9464    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8021    3.9464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0877    4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3732    3.9464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3732    3.1214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3413    2.7089    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0877    2.7089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0877    1.8839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3732    1.4714    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3732    0.6464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4540    0.2037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4540   -0.6213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0558   -1.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7702   -0.5911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7702    0.2339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0558    0.6464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8495   -0.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1350   -0.5911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1350    0.2339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8021    3.1214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 23 24  1  0  0  0  0
 20 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 26  1  0  0  0  0
 14 27  4  0  0  0  0
  9 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5616

>  <JC_XSMILES>
COC1=CC=CC(=N1)C2=CC=C(O)C(CNCC3CC4C=CC3C45CC5)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1528

>  <W2 Pf proliferation inhibition EC50 uM>
0.01987

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>85.94

>  <Powder data?>
Yes

>  <IFI value>
0.043103448

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5617
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9138    0.6674    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  1  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5617

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=C(F)C=CC=C3Cl)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0767

>  <W2 Pf proliferation inhibition EC50 uM>
0.02297

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5619
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -4.2869    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  4  0  0  0  0
 26 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5619

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3Cl)C(=O)CC(C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02722

>  <W2 Pf proliferation inhibition EC50 uM>
0.02205

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-562
  Mrv1591402191617072D          

 15 16  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  2  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-562

>  <JC_XSMILES>
ClC(Cl)=C1N=C(OC1=O)C2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.155

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5621
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -3.5723    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -4.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -4.1251    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1061   -2.9738    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2376    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0012   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 23 29  4  0  0  0  0
 29 30  1  0  0  0  0
 21 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5621

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC(Cl)=C4Cl)C(=O)OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0676

>  <W2 Pf proliferation inhibition EC50 uM>
0.01807

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>87.3

>  <Powder data?>
Yes

>  <IFI value>
0.047619048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5623
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    4.1763   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6513   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8888   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8888    0.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138    0.9059    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1263    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9513    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3638   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1888   -0.5230    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    9.9513   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1263   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  4  0  0  0  0
 13 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5623

>  <JC_XSMILES>
CCN(CC)CCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00716

>  <W2 Pf proliferation inhibition EC50 uM>
0.00601

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
29.85

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5624
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -4.2869    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  4  0  0  0  0
 26 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5624

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3F)C(=O)CC(C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.055

>  <W2 Pf proliferation inhibition EC50 uM>
0.02009

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5625
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  2 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 15 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5625

>  <JC_XSMILES>
CN(CC(O)C1=CC=CC=C1)CC2=CC(=CC=C2O)C3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.223

>  <W2 Pf proliferation inhibition EC50 uM>
0.01417

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>70.93

>  <Powder data?>
Yes

>  <IFI value>
0.008547009

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5626
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    1.6710   -0.7910    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6710   -1.6160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3854   -2.0285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3854   -2.8535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6710   -3.2660    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9565   -2.8535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9565   -2.0285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2420   -1.6160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2420   -0.7910    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5013   -0.4330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6849    0.3713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1705    1.0163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6545    1.0163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1689    0.3713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9853   -0.4330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6710   -4.0910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3854   -4.5035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3854   -5.3285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6710   -5.7410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6710   -6.5660    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.9565   -5.3285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9565   -4.5035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
  9 15  1  0  0  0  0
  5 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5626

>  <JC_XSMILES>
OC1=CC=C(C=C1CN2CCCCCC2)C3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1105

>  <W2 Pf proliferation inhibition EC50 uM>
0.01958

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.017094017

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5627
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -4.2869    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5627

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3F)C(=O)CC(C2)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2539

>  <W2 Pf proliferation inhibition EC50 uM>
0.01856

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5629
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -1.2822   -1.8800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  7 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 21 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
  6 30  4  0  0  0  0
 18 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5629

>  <JC_XSMILES>
CCOC(=O)C1=C(NC(=O)C2=CC=CC=C2)SC3=C(O)C(CN(CC)CC)=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2674

>  <W2 Pf proliferation inhibition EC50 uM>
0.00844

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>46.75

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5633
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -4.2869    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 11 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  4  0  0  0  0
 27 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5633

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Cl)C=C3Cl)C(=O)CC(C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0369

>  <W2 Pf proliferation inhibition EC50 uM>
0.01625

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5634
  Mrv1591402191617072D          

 18 19  0  0  1  0            999 V2000
    4.1602   -1.0828    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.0038   -1.0718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4847   -0.3939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0068    0.2926    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.6811    0.7443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5578    0.9897    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8433    0.5368    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6086   -0.3986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8783   -0.8901    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.7836   -1.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3381   -2.3406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0457   -1.9164    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.7230   -2.3637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0591   -0.6611    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.5079   -1.2569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7752    0.1162    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.0054    0.3735    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4689    0.5664    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  1  0  0  0
  2  3  1  0  0  0  0
  4  3  1  0  0  0  0
  4  5  1  6  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  1  8  1  0  0  0  0
  9  8  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
  1 12  1  0  0  0  0
 12 13  1  6  0  0  0
  9 14  1  1  0  0  0
 14 15  1  1  0  0  0
 14 16  1  0  0  0  0
 16 17  1  1  0  0  0
 16 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5634

>  <JC_XSMILES>
[H][C@@]12CC[C@]3(C)OOC14[C@@]([H])(CC[C@H]2C)[C@@H](C)[C@@H](O)O[C@]4([H])O3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01178

>  <W2 Pf proliferation inhibition EC50 uM>
0.0071

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
44.94

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5639
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -1.3144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  2  0  0  0  0
 21 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 35 39  1  0  0  0  0
M  CHG  2  29   1  30  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5639

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=C(C=C4)[N+]([O-])=O)C(=O)OC5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.03096

>  <W2 Pf proliferation inhibition EC50 uM>
0.01475

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5641
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  1  0  0  0  0
 10 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  9 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 25 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5641

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=C(Cl)C=C3Cl)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1686

>  <W2 Pf proliferation inhibition EC50 uM>
0.01428

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.060240964

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5642
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 24 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5642

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=C(F)C=C3)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02793

>  <W2 Pf proliferation inhibition EC50 uM>
0.01401

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.070588235

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5644
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -3.5723   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1060   -2.8013    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 13 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 12 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 27 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5644

>  <JC_XSMILES>
COCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3Cl)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0504

>  <W2 Pf proliferation inhibition EC50 uM>
0.01325

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023255814

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5645
  Mrv1591402191617072D          

 42 46  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
  3 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  2  0  0  0  0
 32 34  4  0  0  0  0
 24 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  1  0  0  0  0
 38 40  4  0  0  0  0
 40 41  1  0  0  0  0
 40 42  4  0  0  0  0
 35 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5645

>  <JC_XSMILES>
CCC(N(CCC1=CC=CC=C1)C(=O)COC2=CC=C(Cl)C=C2)C3=NC4=CC=CC=C4C(=O)N3C5=CC=C(F)C(Cl)=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.941

>  <W2 Pf proliferation inhibition EC50 uM>
<0.000849

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.45

>  <Powder data?>
No

>  <IFI value>
0.028301887

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5646
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -3.5723   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1060   -2.8013    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 21 22  1  0  0  0  0
 13 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 12 27  1  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 34 37  4  0  0  0  0
 28 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5646

>  <JC_XSMILES>
COCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Cl)C=C3Cl)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02236

>  <W2 Pf proliferation inhibition EC50 uM>
0.01313

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5647
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
   -3.5723    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -4.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1061   -2.9738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2376    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0404   -1.3146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.9277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -2.6421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3730   -2.4706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 33 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5647

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC=C4C)C(=O)OC5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0334

>  <W2 Pf proliferation inhibition EC50 uM>
0.0131

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047619048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5648
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 11 21  4  0  0  0  0
 15 21  4  0  0  0  0
  9 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  7 24  4  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5648

>  <JC_XSMILES>
CCN(CC)CC1=CC(NC2=CC=NC3=CC(Cl)=CC=C23)=CC=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01029

>  <W2 Pf proliferation inhibition EC50 uM>
0.01304

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.025906736

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5651
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 25 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5651

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(F)C=C3)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01834

>  <W2 Pf proliferation inhibition EC50 uM>
0.0124

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5652
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -4.2869    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 11 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 27 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5652

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC(Cl)=C3Cl)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0484

>  <W2 Pf proliferation inhibition EC50 uM>
0.01192

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5653
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -3.5723   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1060   -2.8013    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 13 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 12 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 27 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5653

>  <JC_XSMILES>
COCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3F)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.082

>  <W2 Pf proliferation inhibition EC50 uM>
0.0118

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5655
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  1  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5655

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Cl)C=C3Cl)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02543

>  <W2 Pf proliferation inhibition EC50 uM>
0.01158

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.082352941

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5657
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -4.2869    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5657

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3C)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0127

>  <W2 Pf proliferation inhibition EC50 uM>
0.00978

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5658
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2942    0.4014    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6081   -2.8265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8235   -3.0814    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.2212   -3.3785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0058   -3.1236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1773   -2.3166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -2.0617    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1335   -1.2547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  9 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5658

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2C(SCC(=O)NC3=CC(Cl)=CC=C3OC)=NN=C2C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.096

>  <W2 Pf proliferation inhibition EC50 uM>
<0.001064

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.45

>  <Powder data?>
No

>  <IFI value>
0.044247788

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5659
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 16 30  4  0  0  0  0
 11 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5659

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CN3CCC(CC3)C4=CC=CC=C4)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.508

>  <W2 Pf proliferation inhibition EC50 uM>
0.00912

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.017241379

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-566
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    4.2868    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 21 22  1  0  0  0  0
 11 23  4  0  0  0  0
 23 24  4  0  0  0  0
  8 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-566

>  <JC_XSMILES>
CC(C)CNC(=O)C1=CN=C(NCCCN2CCCCC2C)N=C1NC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.148

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5660
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 25 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5660

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3Cl)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00505

>  <W2 Pf proliferation inhibition EC50 uM>
0.00874

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5663
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
   -3.5723    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -4.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1061   -2.9738    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2376    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0404   -1.3146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.9277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -2.6421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3730   -2.4706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 33 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5663

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC=C4Cl)C(=O)OC5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0558

>  <W2 Pf proliferation inhibition EC50 uM>
0.00738

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.05952381

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5665
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -4.7651   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2251   -2.0171    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4149   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8748   -1.5493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5246   -1.0816    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444   -2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261    0.3216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362    0.1657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763    0.7893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6864    0.6334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9565   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7666   -0.3020    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.4164   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -1.7052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164   -2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763   -3.5762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -2.4848    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7946   -2.4848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9845   -2.6407    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2546   -4.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647   -3.8880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3347   -3.1084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1449   -2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
  5 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 36 37  4  0  0  0  0
  3 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5665

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=C(Cl)C=C2)C(=O)NC3=CC=CC=C3F)=C4N=CC=CC4=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.093

>  <W2 Pf proliferation inhibition EC50 uM>
<0.000572

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.25

>  <Powder data?>
No

>  <IFI value>
0.036697248

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5666
  Mrv1591402191617072D          

 18 18  0  0  0  0            999 V2000
    0.5678    1.9393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5678    1.1143    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2352    0.6294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0198    0.8843    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1913    1.6913    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9760    1.9462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1475    2.7532    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5891    1.3942    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.9803   -0.1553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4652   -0.8227    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2857   -0.7365    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7706   -1.4039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5911   -1.3177    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4350   -2.1576    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.1553   -0.1553    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3297   -0.8227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0997    0.6294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8843    0.8843    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  3  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
  9 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
  2 17  1  0  0  0  0
 17 18  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5666

>  <JC_XSMILES>
CN1C(NNC(N)=S)C(NNC(N)=S)N(C)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00892

>  <W2 Pf proliferation inhibition EC50 uM>
0.00621

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5667
  Mrv1591402191617072D          

 30 35  0  0  0  0            999 V2000
   -1.9562   -0.8856    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042   -1.4986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481   -2.1661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612   -2.7181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612   -3.5431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -3.9556    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -3.5431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -2.7181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -2.3056    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -4.7806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -5.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -6.0181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0047   -6.4306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7191   -6.0181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7191   -5.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0047   -4.7806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1762   -3.9736    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9967   -3.8874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3322   -4.6411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  2 10  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
  3 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 22 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5667

>  <JC_XSMILES>
O=C1N(CC2CN(CCN12)CC3=CC=CC4=C3OCO4)CC5=CC6=CC=CC=C6S5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.727

>  <W2 Pf proliferation inhibition EC50 uM>
<0.000572

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.013888889

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5668
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -4.2869    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5668

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3F)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00671

>  <W2 Pf proliferation inhibition EC50 uM>
0.00541

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-567
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 12 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  4  0  0  0  0
 10 33  4  0  0  0  0
 33 34  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-567

>  <JC_XSMILES>
COC1=CC=C(C=C1Cl)N2N=C(C(=O)NCC(=O)NC3=CC=C(F)C=C3)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.143

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.034883721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5670
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 25 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5670

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Br)C=C3)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01823

>  <W2 Pf proliferation inhibition EC50 uM>
0.00481

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5672
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -4.2869    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 11 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 27 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5672

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Cl)C=C3Cl)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00762

>  <W2 Pf proliferation inhibition EC50 uM>
0.00436

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5674
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -3.5723    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -4.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -4.9501    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1061   -2.9738    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2376    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0012   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
 29 30  1  0  0  0  0
 21 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5674

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=C(Cl)C=C4Cl)C(=O)OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0063

>  <W2 Pf proliferation inhibition EC50 uM>
0.00391

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5676
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3149   -5.3445    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.1354   -5.4307    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4710   -4.6770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2780   -4.5055    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9918   -4.8246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6044   -4.1538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 21 22  2  0  0  0  0
 18 23  1  0  0  0  0
  8 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5676

>  <JC_XSMILES>
CCOC(=O)C(=O)N1C2=CC=C(OC)C=C2C3=C(SSC3=S)C1(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.002431

>  <W2 Pf proliferation inhibition EC50 uM>
0.00319

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-569
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    2.4757   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9908   -5.1657    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -4.3257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0980   -0.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4323    0.3627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2890   -4.3257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8671   -5.1657    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3822   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 10 23  1  0  0  0  0
 17 23  4  0  0  0  0
  6 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-569

>  <JC_XSMILES>
COC(=O)C1=C(SC(S1)=C2C(=S)C(C)(C)NC3=CC(C)=CC=C23)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.14

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-570
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  4 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-570

>  <JC_XSMILES>
NC(=O)\C(NC(=O)C1=CC=CC=C1)=C/C2=CC=CC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.14

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-573
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
   -4.6631   -0.9982    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -4.1914   -0.3213    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -4.5418    0.4256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3694   -0.3914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8977    0.2855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0757    0.2155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7254   -0.5315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1970   -1.2083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8467   -1.9552    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.0191   -1.1383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9033   -0.6015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3635    0.0224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3966   -0.2983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3266   -1.1203    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4768   -1.3077    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9505   -1.6601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7299   -1.3898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9693   -0.6003    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7942   -0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4519   -0.0860    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1288   -0.5577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9322   -0.3703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4962   -0.9724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2568   -1.7619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4534   -1.9493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8894   -1.3472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0645   -1.3635    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4068   -1.8614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4230   -2.6863    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
  4 10  4  0  0  0  0
  7 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 16 14  1  4  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 19 27  1  0  0  0  0
 27 28  4  0  0  0  0
 17 28  4  0  0  0  0
 28 29  2  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-573

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C(Cl)=C1)C2=CC=C(O2)C=c3SC4=NC5=CC=CC=C5n4c3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.127

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-574
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7578   -5.5020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4222   -6.2557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6018   -6.1695    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 22 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 27 28  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-574

>  <JC_XSMILES>
CCOC(=O)N1CCN(CC1)C(=O)CCCCn2c(=S)[nH]c3ccsc3c2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.126

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.022988506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-579
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
   -0.0953   -3.7139    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6473   -3.1008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3924   -2.3162    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4146   -2.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6695   -1.3601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4765   -1.1885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0285   -1.8016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8535   -1.8016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4056   -1.1885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2125   -1.3601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4675   -2.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2744   -2.3162    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8265   -1.7031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5715   -0.9185    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6334   -1.8746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2465   -1.3226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9610   -1.7351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7895   -2.5421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9690   -2.6283    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9154   -2.7578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1085   -2.5862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4410   -3.0712    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9224   -3.7412    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8890   -3.6843    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7736   -2.5862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9666   -2.7578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4543   -3.2723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7899   -4.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6103   -3.9398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7819   -3.1328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0674   -2.7203    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  4  0  0  0  0
  8 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
  7 25  4  0  0  0  0
 25 26  4  0  0  0  0
  4 26  4  0  0  0  0
  2 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 27 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-579

>  <JC_XSMILES>
O=C(NC1=CC=C2C3=CC=C(NC(=O)C4=CC=CS4)C=C3S(=O)(=O)C2=C1)C5=CC=CS5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.109

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037878788

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-581
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  3  0  0  0  0
  9 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 17 27  1  0  0  0  0
 22 27  4  0  0  0  0
 12 28  4  0  0  0  0
 28 29  4  0  0  0  0
  7 29  4  0  0  0  0
 29 30  4  0  0  0  0
  4 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-581

>  <JC_XSMILES>
CCOC1=CC=C2C=C(C#N)C(SCC(=O)N3CC(=O)NC4=CC=CC=C34)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.107

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-582
  Mrv1591402191617072D          

 26 28  0  0  1  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4647   -4.0640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0778   -4.6160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8624   -4.3611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0339   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -4.3257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6318   -4.9932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4522   -4.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9372   -5.5744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6016   -6.3281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0865   -6.9955    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9070   -6.9093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7811   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2962   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  5  3  1  6  0  0  0
  5  6  1  0  0  0  0
  7  6  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  7 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 25 26  4  0  0  0  0
 19 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-582

>  <JC_XSMILES>
CNC(=O)[C@@H]1C[C@H](CN1CC2=CC=CC=C2)NCC3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.102

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-584
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 15 21  4  0  0  0  0
 10 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
  8 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-584

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=NN(CC(=O)NC3=CC=CC(C)=C3)C(=O)C4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.088

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.011764706

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-585
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -7.8592    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
  5 15  4  0  0  0  0
 15 16  2  0  0  0  0
 11 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  2  0  0  0  0
 28 31  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-585

>  <JC_XSMILES>
COCCN1C(=S)NC2=CC(=CC=C2C1=O)C(=O)NCCC3=CC=C(C=C3)S(N)(=O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.08

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-587
  Mrv1591402191617072D          

 39 41  0  0  0  0            999 V2000
   -4.1027   -2.3848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3882   -2.7973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3882   -3.6223    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6738   -4.0348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9593   -3.6223    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6738   -4.8598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3412   -5.3448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1258   -5.0898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0863   -6.1294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5712   -6.7968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3917   -6.7106    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2356   -7.5505    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7206   -8.2179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3850   -8.9716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2613   -6.1294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7763   -6.7968    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9559   -6.7106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4709   -7.3780    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6203   -5.9569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2002   -5.8707    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.5357   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1232   -4.4025    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6753   -3.7894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3427   -4.9455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9558   -5.4975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0063   -5.3448    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 24 37  4  0  0  0  0
 21 37  4  0  0  0  0
 37 38  1  0  0  0  0
 15 39  4  0  0  0  0
  6 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-587

>  <JC_XSMILES>
CCOC(=O)C1=C(C)C(C(=O)OCC)=C(NC(=O)CSC2=NN=C(CNC(=O)COC3=CC=CC=C3)N2C)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.076

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.011904762

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-589
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9638    0.0501    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5159   -0.5630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1034   -1.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2964   -1.1059    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.4389   -2.0311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2594   -2.1174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5950   -2.8710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1100   -3.5385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2896   -3.4522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9540   -2.6986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  2  0  0  0  0
  3  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
  7 12  4  0  0  0  0
 13  9  1  0  0  0  0
 13 14  2  0  0  0  0
 15 14  1  4  0  0  0
 15 16  2  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-589

>  <JC_XSMILES>
CN1C(=O)N(C)C2=CC(=CC=C12)C=NN=C3NC=C(S3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.071

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-59
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 27 28  1  0  0  0  0
  6 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-59

>  <JC_XSMILES>
CCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=C(Cl)C=C3C)C(=O)CCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1

>  <W2 Pf proliferation inhibition EC50 uM>
1.736

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>0.3052

>  <Powder data?>
No

>  <IFI value>
0.029126214

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-590
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
   -2.2337    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9962    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9962    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2337    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2982   -0.3960    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308    0.4290    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 17 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 15 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-590

>  <JC_XSMILES>
CC1=CC=C(C=C1)S(=O)(=O)NC2=NN3C(C=C(NC3=N2)C4=CC=CC=C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.066

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.02247191

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-592
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -1.5365    1.2104    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5365    0.3854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8220   -0.0271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8220   -0.8521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5365   -1.2646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2509   -0.8521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2509   -0.0271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5365   -2.0896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2509   -2.5021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8220   -2.5021    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8220   -3.3271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5365   -3.7396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2509   -3.3271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9654   -3.7396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9654   -4.5646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2509   -4.9771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2509   -5.8021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5365   -6.2146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8220   -5.8021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1075   -6.2146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1075   -7.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8220   -7.4521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5365   -7.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5365   -4.5646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1075   -2.0896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1692   -1.2669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4356   -0.7057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2514   -0.8287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6639   -1.5432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3625   -2.3111    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5741   -2.5543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4512   -3.3701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 16 24  4  0  0  0  0
 12 24  4  0  0  0  0
 10 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 25 31  1  0  0  0  0
 31 32  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-592

>  <JC_XSMILES>
FC1=CC=C(C=C1)C(=O)N(CC2=CC=CC(OC3=CC=CC=C3)=C2)C4CCCCNC4=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.063

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-594
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  2  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-594

>  <JC_XSMILES>
COC1=CC=CC=C1NC(=O)C2=NNC(=O)C3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.058

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-595
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.0940    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7087    0.8085    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  3  0  0  0  0
  8 20  4  0  0  0  0
 20 21  4  0  0  0  0
  6 21  4  0  0  0  0
 21 22  4  0  0  0  0
  3 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-595

>  <JC_XSMILES>
COC1=CC=C2N=C(NC(=O)C3=CC=C(C=C3)C#N)SC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.058

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.010204082

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-599
  Mrv1591402191617072D          

 16 16  0  0  0  0            999 V2000
   -0.3382    3.8913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1632    3.8913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757    3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9882    2.4623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2901    3.5893    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2901    4.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0046    4.8268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757    4.8268    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612    2.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1467    2.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5678    1.9393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5678    1.1143    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2352    0.6294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9803   -0.1553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1553   -0.1553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0997    0.6294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  2  0  0  0  0
  3  9  1  0  0  0  0
  9 10  3  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 16  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-599

>  <JC_XSMILES>
CCC(C)(OC(C)=O)C#CCN1CCCC1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.046

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-600
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -1.3222    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    2.0009    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    1.1759    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0597   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1953   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0203   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2752   -1.7840    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5052   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1696   -3.9898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3491   -4.0760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1358   -3.4086    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0136   -4.8297    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4985   -5.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1630   -6.2508    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3190   -5.4109    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6546   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4750   -4.5710    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 16 23  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-600

>  <JC_XSMILES>
COC1=CC=C(C=C1Cl)C2=CC=C(O2)C=C3C(=O)NC(=S)NC3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.044

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-601
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    1.7605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    3.1895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7474    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  3  0  0  0  0
 11 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
  8 33  4  0  0  0  0
 28 33  4  0  0  0  0
  6 34  4  0  0  0  0
  2 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-601

>  <JC_XSMILES>
CC1=CC=CC(NC2=NN=C(C3=CC=C(C)C(=C3)S(=O)(=O)NC(C)(C)C#C)C4=CC=CC=C24)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.044

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-603
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    3.0368   -2.7887    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4229   -2.4457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6778   -3.2303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1258   -3.8434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -3.6718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0639   -2.8872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6159   -2.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9130   -0.8764    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5798   -0.8764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1319   -1.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9389   -1.3180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4909   -1.9311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2359   -2.7157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4290   -2.8872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8769   -2.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  3 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
 13 21  4  0  0  0  0
 17 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-603

>  <JC_XSMILES>
O=c1n(C2CCCCC2)c(=S)[nH]c3sc4CN(CCc4c13)CC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.037

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-606
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  5 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  9 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-606

>  <JC_XSMILES>
CC(C)CC1=NC2=CC(=CC=C2CN1CC3=CC=CC=C3)C(=O)NC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.034

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037974684

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-608
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5395   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-608

>  <JC_XSMILES>
CCNC(=O)NS(=O)(=O)C1=CN=CC=C1SC2=CC=CC(C)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.032

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-609
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    3.1465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604    3.9312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2673    4.1027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5223    4.8873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9702    5.5004    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1633    5.3289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083    4.5442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  5  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  4 11  4  0  0  0  0
 12  9  1  4  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-609

>  <JC_XSMILES>
CC1=CC2=C(C=C1C)N(C=N2)N=CC3=CC=CN=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.021

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-61
  Mrv1591402191617072D          

 34 35  0  0  1  0            999 V2000
    7.1447    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    8.4161    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    8.5737    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1448    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6598    7.8460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    6.7660    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.2869    7.1785    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869    8.0035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    8.4160    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    8.4160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    9.2410    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.2868    9.6535    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1855   10.2855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2461   10.2856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303    8.4161    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    9.6536    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.1447   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    9.2411    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    8.5736    9.6536    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0014    5.9410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869    5.5285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869    4.7035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9544    4.2186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6994    3.4340    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8744    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3895    2.7665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6195    4.2186    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  2  0  0  0  0
  8  9  1  4  0  0  0
 10  9  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 15 14  1  0  0  0  0
 15 16  1  6  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 22 20  1  0  0  0  0
 22 23  1  6  0  0  0
 24 22  1  0  0  0  0
 24  2  1  0  0  0  0
 24 25  1  1  0  0  0
 10 26  1  1  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-61

>  <JC_XSMILES>
C[C@H]1CCCC(C)=CC[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)\C(C)=C\C2=CSC(C)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0854

>  <W2 Pf proliferation inhibition EC50 uM>
0.02581

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.00621

>  <Powder data?>
Yes

>  <IFI value>
0.056603774

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-611
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-611

>  <JC_XSMILES>
CC1CCCN(C1)CC2=NN=NN2C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.011

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-613
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-613

>  <JC_XSMILES>
CC1=C(Cl)C=CC=C1NC(=O)CCC(=O)NNC(=O)C2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.006

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-614
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5269   -3.0308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9966   -2.1123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-614

>  <JC_XSMILES>
CC1CC(C)(C)NC(=S)N1CCC(=O)NCCC2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.006

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-615
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
  8 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  6 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-615

>  <JC_XSMILES>
CC(C)CNC1=NC(NCCN2CCCCC2)=NC=C1C(=O)NCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.005

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-616
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
   -3.4656    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    3.2384    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -3.7741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -6.2491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7982   -6.7340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0531   -7.5187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8781   -7.5187    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1331   -6.7340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4669   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4669    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    2.4134    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 12 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 10 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
  6 35  4  0  0  0  0
 35 36  4  0  0  0  0
  3 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-616

>  <JC_XSMILES>
COC1=CC=C(CCNC2=NC(NCCCN3C=CN=C3)=NC=C2C(=O)NCC4=CC=CC=C4)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.004

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.00952381

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-617
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 18 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-617

>  <JC_XSMILES>
CN1CCN(CC1)C(=O)C2=CC=CC(=C2)C3=NC(=CN=C3N)C4=CC=NC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.002

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-618
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2773   -1.9371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1100   -1.2663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 10 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-618

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3NC2(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.97

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046153846

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-620
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0968   -3.8419    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  2  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  3  0  0  0  0
 11 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-620

>  <JC_XSMILES>
O=C(N1CCOCC1)C2=NC(C#N)=C(O2)N3CCOCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.995

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-625
  Mrv1591402191617072D          

 29 30  0  0  0  0            999 V2000
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 11 19  4  0  0  0  0
 19 20  4  0  0  0  0
  8 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-625

>  <JC_XSMILES>
CC(C)CNC(=O)C1=CN=C(NCCCN(C)C)N=C1NCCC2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.983

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009615385

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-626
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2252    0.8227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8299    1.3838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6457    1.2609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0582    0.5464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7568   -0.2216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9685   -0.4647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 10 16  1  0  0  0  0
  9 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
  7 20  4  0  0  0  0
 20 21  4  0  0  0  0
  4 21  4  0  0  0  0
 21 22  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-626

>  <JC_XSMILES>
OC(=O)C1=CNC2=CC(N3CCCCCC3)=C(F)C=C2C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.8

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-629
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5517    3.0153    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9234    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -0.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -0.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -0.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -0.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.8084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1903    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9234    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9234    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9234    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  4  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 12 28  4  0  0  0  0
 28 29  2  0  0  0  0
 28 30  4  0  0  0  0
 10 30  4  0  0  0  0
 30 31  1  0  0  0  0
  6 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 39 41  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-629

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N=c2sc(=CC3=CC=CC=C3OCC4=CC=CC=C4)c(=O)n2C1C5=CC=CC=C5OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
9.73

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-633
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -0.0001    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4676    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1269   -2.5071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6118   -3.1746    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3019   -2.5071    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2960   -0.1085    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.1890    0.5589    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.4675    0.6985    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1525   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3324   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1529   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6379   -5.1768    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0035   -3.0883    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  4 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
  9 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  CHG  2  17   1  18  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-633

>  <JC_XSMILES>
CC(=O)C1=C(O)C(=O)N(C1C2=CC=CC=C2[N+]([O-])=O)C3=CC=C(Br)C=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.61

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-635
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    0.9433    4.7720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1721    3.9794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6001    3.3849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9729    3.7812    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2018    2.9886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6297    2.3941    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8585    1.6015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6594    1.4033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2314    1.9978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0323    1.7996    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0026    2.7904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5746    3.3849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3458    4.1775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5701    4.4583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5974    5.2828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3900    5.5117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8526    4.8285    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8882    0.6107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4602    1.2051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2611    1.0070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4899    0.2143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9179   -0.3801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1170   -0.1820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3162    0.0162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5153    0.2143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9433   -0.3801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1424   -0.1820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0864    0.6107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4857    1.2051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2865    1.0070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
  5 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
  8 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 18 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
  7 30  1  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-635

>  <JC_XSMILES>
CC(C)SC1=NC2=C(C(=O)N1CC3=CC=CO3)C4(CCCCC4)CC5=CC=CC=C25

>  <PF proliferation inhibition 3D7 EC50 uM>
9.56

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-636
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1904    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    2.0945    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5253    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 10 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  3  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 22  4  0  0  0  0
 22 23  4  0  0  0  0
  6 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-636

>  <JC_XSMILES>
CCN(CC)C1=CC=C2C(C3=CSC=C3)C(C#N)=C(N)OC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.54

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.090909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-639
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  2 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 14 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-639

>  <JC_XSMILES>
O=C(NCC1=CC=CC=C1)C2=CN=C(NCCN3CCCCC3)N=C2NCCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.95

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.00952381

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-640
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    0.6078   -3.0723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067   -2.6598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212   -3.0723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356   -2.6598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356   -1.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067   -1.8348    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.6402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.8777    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    3.1152    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.8777    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.6402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8476   -0.6697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926   -1.4544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676   -1.4544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -0.6697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.6402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 15 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 28 32  1  0  0  0  0
 26 33  4  0  0  0  0
 12 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-640

>  <JC_XSMILES>
CC1CCCCN1CCCNC2=NC=C(C(=O)NCC3=CC=CC=C3)C(NC4CCCC4)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.943

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009433962

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-645
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-645

>  <JC_XSMILES>
CN(C)CCCNC(=O)C1=CC=C(C=C1)C2=CN=CC(=N2)C3=CC=CC(O)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.923

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-649
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2411   -5.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9862   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1612   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9062   -5.4349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1216   -5.1800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 11 21  4  0  0  0  0
 21 22  4  0  0  0  0
  8 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 25 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-649

>  <JC_XSMILES>
CC(C)CNC(=O)C1=CN=C(NCCC2CCCN2C)N=C1NCC3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.92

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-652
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   10.4583    1.0511    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    9.9063    0.4380    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   10.1612   -0.3466    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0993    0.6095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5473   -0.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7403    0.1680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4854    0.9526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6784    1.1241    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3813   -0.2736    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.0374    1.5657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8444    1.3941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 19 24  4  0  0  0  0
 17 25  4  0  0  0  0
 13 25  4  0  0  0  0
  7 26  4  0  0  0  0
 26 27  4  0  0  0  0
  4 27  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  STY  1   1 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-652

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(NC(=O)CSC2=NN=C3C(NC4=CC=CC=C34)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
9.11

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022900763

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-661
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -4.2962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -4.2703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
  9 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 21 28  4  0  0  0  0
  7 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-661

>  <JC_XSMILES>
CCN(CC)CC1=CC(NC2=NC3=CC=CC=C3N2)=CC(CN(CC)CC)=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.864

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-662
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  7 16  4  0  0  0  0
 11 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-662

>  <JC_XSMILES>
CON(C)C(=O)C1=CC=CC2=CC=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.856

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.032520325

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-664
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6586   -3.7080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4656   -3.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8781   -3.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3260   -2.5519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4976   -1.7450    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 22 26  1  0  0  0  0
 26 27  2  0  0  0  0
 15 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 31 36  1  0  0  0  0
 28 37  4  0  0  0  0
 12 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-664

>  <JC_XSMILES>
CC1CCCCN1CCCNC2=NC=C(C(=O)NCCCN3CCCC3=O)C(NCC4CCCCC4)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.85

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.039215686

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-677
  Mrv1591402191617072D          

 16 16  0  0  0  0            999 V2000
    1.4981    2.1449    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9959    1.4904    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
    0.4936    2.1449    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7581    1.1747    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0738    0.4125    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
    2.7283    0.9147    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7283   -0.0897    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7581   -0.3497    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9959   -0.6654    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
    1.4981   -1.3199    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4936   -1.3199    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2337   -0.3497    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0821    0.4125    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7366   -0.0897    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7366    0.9147    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2337    1.1747    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  2 16  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-677

>  <JC_XSMILES>
OP1(O)=NP(O)(O)=NP(O)(O)=NP(O)(O)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.811

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.015151515

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-678
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 13 19  1  0  0  0  0
  6 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-678

>  <JC_XSMILES>
COC1=CC=C(OCCOCCN2CCN(C)CC2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>8.08

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-680
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
  6 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
  3 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-680

>  <JC_XSMILES>
COC1=CC=C(NC(=O)COC2=CC=CC=C2C(C)C)C(OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
7.95

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.014925373

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-683
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -2.8579    3.3000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.1434    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731    3.2955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800    3.4670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925    2.7525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4130    2.6663    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.0405    2.1394    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 14 19  4  0  0  0  0
  7 20  4  0  0  0  0
 20 21  4  0  0  0  0
  4 21  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-683

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(OCCOC(=O)C2=CC=C(Br)O2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.782

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.007692308

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-685
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9049   -6.6724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599   -7.4570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849   -7.4570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2398   -6.6724    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0244   -6.4175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
  8 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  6 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-685

>  <JC_XSMILES>
CC(C)CNC1=NC(NCCC2CCCN2C)=NC=C1C(=O)NCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.775

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019047619

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-686
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0300    4.1626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8370    3.9911    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919    3.2065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3890    4.6042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1341    5.3888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6861    6.0019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4931    5.8304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7480    5.0458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1960    4.4327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
  6 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
 30 31  4  0  0  0  0
  5 31  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  31
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-686

>  <JC_XSMILES>
COC(=O)C1=C(NC(=O)C(C)N2CCN(CC2)C3CCCCC3)C4=CC(Cl)=CC=C4N1

>  <PF proliferation inhibition 3D7 EC50 uM>
7.74

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.102040816

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-687
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1904    3.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    4.5695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    4.5695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5253    3.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9441    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7511    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1636    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6116   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 11 21  4  0  0  0  0
 21 22  4  0  0  0  0
  8 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 24 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-687

>  <JC_XSMILES>
CC(C)CNC(=O)C1=CN=C(NCCCN2CCCC2)N=C1NC3CCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.774

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019047619

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-697
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -2.7512   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -3.7741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -6.2491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3693   -6.7340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6242   -7.5187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4492   -7.5187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7041   -6.7340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  2 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  1  0  0  0  0
 14 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-697

>  <JC_XSMILES>
O=C(NCC1=CC=CC=C1)C2=CN=C(NCCCN3CCCC3)N=C2NCC4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.733

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009708738

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-699
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4539   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1039   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2934   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2934   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0079   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7224   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7224   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0079   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  2 10  4  0  0  0  0
  6 10  4  0  0  0  0
  5 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-699

>  <JC_XSMILES>
CC1=CC=C(C2=NSN=C12)S(=O)(=O)NNC(=O)C3CCC(CC3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.727

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-702
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 18 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 33 34  4  0  0  0  0
 28 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-702

>  <JC_XSMILES>
CCOC(=O)N1CCN(CC1)C(=O)CSC2=NC(=CN2C3=CC=C(C)C=C3)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.71

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-703
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 10 15  1  0  0  0  0
  8 16  4  0  0  0  0
  3 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-703

>  <JC_XSMILES>
CSC1=NC(N)=NC(SC2CCCC=C2)=C1C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
7.06

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-705
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5332    2.9644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9811    3.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3936    4.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2006    4.1205    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8137    4.6725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 11 21  4  0  0  0  0
 21 22  4  0  0  0  0
  8 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-705

>  <JC_XSMILES>
CC(C)CNC(=O)C1=CN=C(NCCC2CCCN2C)N=C1NCCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.699

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.00952381

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-707
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
 11 29  4  0  0  0  0
 29 30  4  0  0  0  0
  8 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-707

>  <JC_XSMILES>
CC1=CC=CC(=C1)C2=CC=C(NC(=O)C3CCN(CC3)CC4=CN=C(C)N=C4)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>6.88

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-715
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6194   -5.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8743   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6993   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9543   -5.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7389   -5.1800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9104   -4.3730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6950   -4.1181    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8666   -3.3111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6512   -3.0562    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8227   -2.2492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2096   -1.6972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3811   -0.8902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1658   -0.6352    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7680   -0.3382    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9396    0.4688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7242    0.7238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3373    0.1717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.1219    0.4267    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2934    1.2336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.6803    1.7857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8957    1.5307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4250   -1.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8119   -1.4001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0273   -1.6550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3598   -1.1701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6924   -1.6550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9473   -2.4396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7723   -2.4396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2535   -2.7591    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  2  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 13 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 26 30  1  0  0  0  0
 24 31  4  0  0  0  0
 10 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-715

>  <JC_XSMILES>
CN1CCCC1CCNC2=NC=C(C(=O)NCC3=CC=CC=C3)C(NC4CCCC4)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.658

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019417476

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-717
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9543   -7.9099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -8.6945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -8.6945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6194   -7.9099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  2 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  1  0  0  0  0
 14 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-717

>  <JC_XSMILES>
O=C(NCC1=CC=CC=C1)C2=CN=C(NCCCN3CCCC3)N=C2NCCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.648

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019047619

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-718
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    9.2881   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197   -4.5375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   19.2907   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 17 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-718

>  <JC_XSMILES>
CCCCCCC(=O)NC1CCC(CC1)NC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.63

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-723
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-723

>  <JC_XSMILES>
CC(C)CNC1=NC(NCCCN)=NC=C1C(=O)NCCC2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.598

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019047619

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-725
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    4.3355    2.0414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3613    1.2168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0883    0.8268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6601    0.7822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8963    1.0941    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3637    0.4640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7983   -0.2372    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5995   -0.0406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2295   -0.5732    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4083   -0.9642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8429   -1.6655    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6675   -1.6397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1021   -2.3409    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9267   -2.3152    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7121   -3.0679    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1467   -3.7692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7567   -4.4962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1914   -5.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0159   -5.1717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4059   -4.4447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9713   -3.7434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3613   -3.0164    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.8014   -5.9244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4114   -6.6514    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.5284   -6.3144    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.0744   -5.5344    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.5837   -0.9900    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1491   -0.2887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3245   -0.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1101    0.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2799    1.1137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1045    1.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391    0.4383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 18 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 10 27  2  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
  6 33  1  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-725

>  <JC_XSMILES>
CC(C)C1N=C2N(C1=O)C(SCC(=O)NC3=CC(=CC=C3Cl)C(F)(F)F)=NC4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
5.91

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-727
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    7.5658    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9232    0.9826    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4383    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9232    2.3174    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9947    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9947    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7092    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4236    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1381    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4236    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  9 12  4  0  0  0  0
 12 13  4  0  0  0  0
  6 13  4  0  0  0  0
 13 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
  7 24  4  0  0  0  0
 24 25  4  0  0  0  0
  4 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-727

>  <JC_XSMILES>
CCCC1=CC2=C(OC(CC)=C(C2=O)C3=CC=C4OCOC4=C3)C=C1OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
5.84

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.048192771

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-728
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.9519    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    5.8098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    3.6664    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    4.3808    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8913    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3038    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8913    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3038    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.9519    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  7 11  4  0  0  0  0
 11 12  4  0  0  0  0
  4 12  4  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 18 24  4  0  0  0  0
 16 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 28 34  4  0  0  0  0
 26 35  4  0  0  0  0
 14 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-728

>  <JC_XSMILES>
CCOC1=CC=C2N=C(SC2=C1)SC3=NC(NC4=CC=CC(C)=C4)=NC(NC5=CC=CC(C)=C5)=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
5.81

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012048193

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-729
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -3.3722   -6.2832    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -3.0366   -5.5295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4491   -4.8150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8971   -4.2019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2296   -5.3580    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164   -4.8395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -3.4105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 15 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-729

>  <JC_XSMILES>
BrC1=CC=C(S1)S(=O)(=O)NCCC(=O)N2CCC3=CC=CC=C3C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>5.6

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-73
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-73

>  <JC_XSMILES>
O=C(CC1=CC=CN=C1)N2CCC(CC2)OC3=CC=NC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.626

>  <W2 Pf proliferation inhibition EC50 uM>
0.1409

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.1039

>  <Powder data?>
No

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-730
  Mrv1591402191617072D          

 36 41  0  0  0  0            999 V2000
   -1.8212    2.1599    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.9979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1060   -4.8999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6580   -5.5130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2455   -6.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4385   -6.0559    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8254   -6.6080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9117   -7.4284    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1580   -7.7640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6060   -7.1509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0185   -6.4364    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 22 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 27 31  4  0  0  0  0
 14 32  4  0  0  0  0
 10 32  4  0  0  0  0
 32 33  1  0  0  0  0
  7 33  1  0  0  0  0
 33 34  2  0  0  0  0
  5 35  4  0  0  0  0
 35 36  4  0  0  0  0
  2 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-730

>  <JC_XSMILES>
ClC1=CC=C(CN2C(=O)C3=CC=CC(N4CCN(CC4)CC5=CC=CN5C6=NC=CS6)=C3C2=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
5.47

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.025862069

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-731
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    3.2704    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  3  0  0  0  0
  4  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  3 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-731

>  <JC_XSMILES>
CCC1=C(C#N)C(N)=NC2=C1C(N)=C(S2)C(=O)C3=CC=C(Br)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
5.46

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-732
  Mrv1591402191617072D          

 33 34  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4681   -0.9019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6397   -0.0950    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0202   -1.5150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6077   -2.2295    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007   -2.0580    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8407   -1.4288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3256   -2.0962    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1762   -0.6751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
  5 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-732

>  <JC_XSMILES>
CCCC(N(C(=O)C1=C(N)C(=NS1)C(N)=O)C2=CC=C(C=C2)C(C)C)C(=O)NCCC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
5.44

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.048387097

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-733
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -1.8846   -4.8582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6296   -4.0736    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8227   -3.9021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5677   -3.1175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2392   -2.9459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7913   -3.5590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5363   -4.3437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2706   -4.5152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5256   -5.2998    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.3325   -5.4713    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0265   -5.9129    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5983   -3.3875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1503   -4.0006    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5983   -0.4834    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
  6 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 14 28  4  0  0  0  0
 18 28  4  0  0  0  0
M  CHG  2   9   1  10  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-733

>  <JC_XSMILES>
COC1=CC=C(C=C1[N+]([O-])=O)C(=O)N2N=C(N)C3=CC4=CC=C(C)C=C4N=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
>5.42

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-734
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    1.3222    7.2402    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    7.2402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    9.3027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   10.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   10.9527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   10.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.5277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    2.2902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8476    1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926    1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676    1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127    1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    6.0027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  2 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 20 24  1  0  0  0  0
 15 25  4  0  0  0  0
 25 26  4  0  0  0  0
 12 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-734

>  <JC_XSMILES>
O=C(NCCC1=CC=CC=C1)C2=CN=C(NCCCN3CCCC3)N=C2NC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.541

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009615385

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-736
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
   -0.7145   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
  2 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-736

>  <JC_XSMILES>
ClC1=CC=C(OC(=O)CNC(=O)C2=CC=CC=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.537

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-739
  Mrv1591402191617072D          

 30 31  0  0  0  0            999 V2000
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 14 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  7 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  5 26  4  0  0  0  0
 25 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-739

>  <JC_XSMILES>
COC(=O)C1=CC(NC(=S)NC(=O)C2=C(OC)C=CC=C2OC)=CC(=C1)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
5.17

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-74
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  6 21  4  0  0  0  0
 21 22  4  0  0  0  0
  3 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-74

>  <JC_XSMILES>
COC1=CC=C(CN2CCC(CC2)SC3=NC=CC=N3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.444

>  <W2 Pf proliferation inhibition EC50 uM>
0.95

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.702

>  <Powder data?>
No

>  <IFI value>
0.013888889

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-740
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3088   -3.6695    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 11 17  1  0  0  0  0
 17 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 19 26  4  0  0  0  0
  9 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-740

>  <JC_XSMILES>
COC1=CC=C(OC)C(NC2=C(Cl)C(=O)N(C2=O)C3=CC=C(C)C(Cl)=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
5.07

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-743
  Mrv1591402191617072D          

 51 58  0  0  0  0            999 V2000
   -3.4088    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6944    2.1918    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    2.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654   -1.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6944   -1.9332    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4088   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771    0.7967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320    1.5814    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8620    0.1293    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771   -0.5381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320   -1.3228    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6870    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0995    0.8438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9245    0.8438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3370    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9245   -0.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0995   -0.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1620    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5745    0.8438    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5745   -0.5852    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3995   -0.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    2.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    3.0168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    3.4293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    3.0168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    2.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6717    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1533    0.1293    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -1.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -2.7582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -3.1707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635   -2.7582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635   -1.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  4  0  0  0  0
 11 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 25 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 30 33  1  0  0  0  0
 33 34  2  0  0  0  0
 33 35  1  0  0  0  0
 35 36  1  0  0  0  0
 21 37  1  0  0  0  0
  9 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 38 43  4  0  0  0  0
 37 44  1  0  0  0  0
 19 44  1  0  0  0  0
 44 45  2  0  0  0  0
 19 46  1  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 48 49  4  0  0  0  0
 49 50  4  0  0  0  0
 50 51  4  0  0  0  0
 46 51  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-743

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C(C3=CC=C(OC)C=C3)C4(C5C(C(=O)N(C5=O)C6=CC=C(C=C6)C(=O)OC)C2(C7=CC=CC=C7)C4=O)C8=CC=CC=C8

>  <PF proliferation inhibition 3D7 EC50 uM>
4.83

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-744
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
   -2.1434    0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8984    1.9856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4504    1.3725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0379    0.6580    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2309    0.8295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
  5 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-744

>  <JC_XSMILES>
ClC1=CC=C(OCCCC(=O)NCCCN2C=CN=C2)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.48

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.015625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-747
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6753    2.1394    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1232    2.7525    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5357    3.4670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3427    3.2955    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2002    4.2207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6203    4.3069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9559    5.0606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4709    5.7280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8065    6.4817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3495    5.6418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6851    4.8881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8545    0.3627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3848   -0.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
  7 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  2  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
  6 30  4  0  0  0  0
 30 31  4  0  0  0  0
  3 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-747

>  <JC_XSMILES>
COC1=CC=C2N(C(=O)CSC3=NN=C(O3)C4=CC=C(C)C=C4)C(C)(C)C=C(C)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.467

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-748
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
  6 20  4  0  0  0  0
  2 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-748

>  <JC_XSMILES>
CC1=CC=NC(NC2=NC(=CS2)C3=CC=C(Cl)C=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.51

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.064516129

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-75
  Mrv1591402191617072D          

 59 62  0  0  1  0            999 V2000
   -5.0505   -1.0613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7604   -0.2890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9466   -0.1541    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.4228   -0.7915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6565    0.6182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8426    0.7532    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.5525    1.5255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7386    1.6604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2148    1.0230    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.6781    1.6496    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5049    0.2507    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3188    0.1158    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.6089   -0.6565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5046    0.6033    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.9244   -0.1070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0848    1.3135    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2056    0.1835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1972   -0.6415    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9243    0.5886    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6345    0.1688    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.3916    0.4967    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.9373   -0.1221    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8288   -0.2645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3348    0.3872    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1566   -1.0215    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.6649   -1.6840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9762   -1.1162    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4679   -0.4537    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3040   -1.8732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8122   -2.5357    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1235   -1.9679    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.6153   -1.3054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4348   -1.4001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7626   -2.1571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2709   -2.8196    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4513   -2.7249    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9596   -3.3874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2874   -4.1444    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1401   -3.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6483   -3.9552    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8288   -3.8605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3370   -4.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5010   -3.1035    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.9927   -2.4410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6814   -3.0088    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1897   -3.6713    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3536   -2.2518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8453   -1.5893    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5340   -2.1571    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.0423   -2.8196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2227   -2.7249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1051   -1.9679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3866   -1.3054    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -1.4001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7123   -0.6525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5116   -0.8568    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5713    1.3018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3585    1.5487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9639    1.8601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  0  0  0  0
  3  4  1  1  0  0  0
  3  5  1  0  0  0  0
  6  5  1  1  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  9  8  1  0  0  0  0
  9 10  1  1  0  0  0
  9 11  1  0  0  0  0
 12 11  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  6  0  0  0
  9 14  1  6  0  0  0
 14 15  1  0  0  0  0
 14 16  1  1  0  0  0
 14 17  1  6  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 20 19  1  1  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 25 23  1  0  0  0  0
 25 26  1  6  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 29 30  2  0  0  0  0
 31 29  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 31 36  1  6  0  0  0
 36 37  1  0  0  0  0
 37 38  2  0  0  0  0
 37 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  2  0  0  0  0
 43 41  1  0  0  0  0
 43 44  1  1  0  0  0
 43 45  1  0  0  0  0
 45 46  1  0  0  0  0
 45 47  1  0  0  0  0
 47 48  2  0  0  0  0
 49 47  1  0  0  0  0
 49 50  1  0  0  0  0
 50 51  1  0  0  0  0
 51 52  1  0  0  0  0
 52 53  1  0  0  0  0
 53 54  1  0  0  0  0
 49 54  1  1  0  0  0
 54 55  1  0  0  0  0
 20 55  1  0  0  0  0
 55 56  2  0  0  0  0
 21 57  1  6  0  0  0
 57 58  1  0  0  0  0
 57 59  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-75

>  <JC_XSMILES>
CC[C@H](C)C[C@H]1CC[C@@](O)(O[C@@H]1C)[C@](C)(O)C(=O)N[C@H]2[C@@H](OC(=O)[C@@H](C)N(O)C(=O)[C@@H]3CCCNN3C(=O)CNC(=O)[C@H](C)N(O)C(=O)[C@H]4CCCNN4C2=O)C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.438

>  <W2 Pf proliferation inhibition EC50 uM>
0.567

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.465

>  <Powder data?>
No

>  <IFI value>
0.34351145

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-751
  Mrv1591402191617072D          

 12 13  0  0  0  0            999 V2000
    3.2789    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8092   -1.0445    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7486   -1.0445    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  2  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-751

>  <JC_XSMILES>
OC1CCS(=O)(=O)C2=C1C=CS2

>  <PF proliferation inhibition 3D7 EC50 uM>
4.18

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-752
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.0190   -4.8395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.8440   -3.4105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.8997   -4.2019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4517   -4.8150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0392   -5.5295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2942   -6.3141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7421   -6.9272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9351   -6.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6802   -5.9711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2322   -5.3580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  2  0  0  0  0
 15 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 23 31  1  0  0  0  0
 26 31  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  11
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-752

>  <JC_XSMILES>
CN(C)CCNC(=O)C1=CNC2=CC=C(C=C2C1=O)S(=O)(=O)N3CCC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.418

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-756
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  9 19  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
  2 20  4  0  0  0  0
  7 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-756

>  <JC_XSMILES>
ClC1=CC=C2N=C(C=C(C(=O)NC3=CC=CN=C3)C2=C1)C4=CC=CN=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
3.96

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-760
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   10.6104   -3.7741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -3.7741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -1.2991    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    2.0009    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959    4.8884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959    5.7134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104    6.1259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3248    5.7134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3248    4.8884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5633   -5.4965    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3084   -6.2812    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.4834   -6.2812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2284   -5.4965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 14 29  4  0  0  0  0
 10 29  4  0  0  0  0
  7 30  1  0  0  0  0
  3 30  1  0  0  0  0
  2 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 31 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-760

>  <JC_XSMILES>
O=C(N1CCCC(COC2=CC=CC(CN3CCC(CC3)CC4=CC=CC=C4)=C2)C1)C5=NSN=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>3.67

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.019417476

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-763
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    1.3556   -6.4729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -6.0604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -0.7477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5970   -1.6662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -1.2680    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3429   -1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1129   -3.3875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 10 17  1  0  0  0  0
 17 18  2  0  0  0  0
 11 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
  9 25  1  0  0  0  0
 20 25  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  22
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-763

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2C3=C(CC(C)(C)CC3=O)NC4=NNC(C)=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
>3.32

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.051948052

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-766
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    3.4990    0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.1970    1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3720   -0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.3646    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -2.6021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5023   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2168   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2168   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5023   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878   -0.5396    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  6 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  5 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-766

>  <JC_XSMILES>
CS(=O)(=O)C1=C(C2CCCN(C2)C(=O)C3=CC=CC=N3)N4N=CN=C4N=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3107

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-767
  Mrv1591402191617072D          

 23 23  0  0  0  0            999 V2000
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -4.4270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -2.9980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 13 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-767

>  <JC_XSMILES>
CCCCN(CCCC)S(=O)(=O)C1=NC(C)=C(Cl)C(C)=C1C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
3.093

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-769
  Mrv1591402191617072D          

 16 18  0  0  0  0            999 V2000
    3.0332    1.6803    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3912    0.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2162    0.9370    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7305    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5189    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1237   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9401   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1517   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5470   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8037   -0.8703    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0604   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4556   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6673   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4837   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0884    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8768    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  1  0  0  0  0
 11 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-769

>  <JC_XSMILES>
O=C1NC2=CC=CC=C2SC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
>3.027

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-773
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0339   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8186   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9901   -2.4922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7747   -2.2373    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.3770   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5924   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-773

>  <JC_XSMILES>
NC(=O)C1=CC=C(C=C1)N2N=NN=C2SCC3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.826

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015873016

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-776
  Mrv1591402191617072D          

 47 54  0  0  0  0            999 V2000
    6.3653    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5403    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278    1.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028    1.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8903    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0653    0.6243    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804   -0.0431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353   -0.8278    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804    1.2917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353    2.0764    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    3.9243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2875    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1125    0.6243    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -2.6757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8903   -0.8047    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.3028   -1.5191    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.1057   -1.0596    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 13 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
  9 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 22 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 29 36  2  0  0  0  0
 13 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
  5 43  4  0  0  0  0
 43 44  4  0  0  0  0
  2 44  4  0  0  0  0
 43 45  1  0  0  0  0
 45 46  1  0  0  0  0
 45 47  2  0  0  0  0
M  CHG  2  45   1  46  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-776

>  <JC_XSMILES>
CC1=CC=C(N2C(=O)C3C(C2=O)C5(C4=CC=CC=C4)C(=O)C3(C6=CC=CC=C6)C(C7=CC=CC=C7)=C5C8=CC=CC=C8)C(=C1)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.642

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-779
  Mrv1591402191617072D          

 20 23  0  0  1  0            999 V2000
   -0.2162    4.0966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4149    3.5957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2966    2.7988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4527    2.5026    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.9277    2.2978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6833    2.6264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3723    2.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0766    2.5247    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4260    1.3055    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.1022    0.8329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3833    0.4610    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.5557    0.3058    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.7444   -0.4776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7593    0.0703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2822    0.7593    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7864    1.5254    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.0386    1.8254    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6992    1.3752    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.8031    2.1742    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2379    1.1626    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  9  7  1  0  0  0  0
  9 10  1  1  0  0  0
 11 10  1  1  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  6  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 16 15  1  0  0  0  0
 16  5  1  0  0  0  0
 16 17  1  1  0  0  0
 18 16  1  0  0  0  0
  9 18  1  0  0  0  0
 18 19  1  1  0  0  0
 18 20  1  0  0  0  0
 12 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-779

>  <JC_XSMILES>
C\C=C(/Cl)C1=CC(=O)[C@]23C[C@H]2[C@@]4(C)CO[C@@]1(O)[C@@]3(O)O4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2053

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.068627451

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-78
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    4.9524    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3454    2.4777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7044    2.0361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9594    2.8207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7663    2.9922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0213    3.7769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8282    3.9484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3803    3.3353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1253    2.5507    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3184    2.3791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  3 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 14 25  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-78

>  <JC_XSMILES>
CC1=C(C(=O)NCC2=CC=CN=C2)C3=C(O1)C(=O)C4=CC=CC=C4C3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.503

>  <W2 Pf proliferation inhibition EC50 uM>
1.75

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.913

>  <Powder data?>
Yes

>  <IFI value>
0.175

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-780
  Mrv1591402191617072D          

 20 23  0  0  0  0            999 V2000
    3.3523   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5433   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1067   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
 10 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   9
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-780

>  <JC_XSMILES>
OC1=C2CCCCC2=NC3=CC(=NN13)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.927

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-782
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  2  8  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 17 24  4  0  0  0  0
 12 25  4  0  0  0  0
 25 26  2  0  0  0  0
 25 27  4  0  0  0  0
  9 27  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  10
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-782

>  <JC_XSMILES>
CC1CN(CC(C)O1)C2=NC3=C(CCN(C3)C4=CC(Cl)=NC(C)=N4)C(=O)N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1757

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-784
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2786   -8.1246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8913   -7.4538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 18 19  1  0  0  0  0
 12 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-784

>  <JC_XSMILES>
CCCCOC1=CC=C(C=C1)N2C(N)=NC(N)=NC2(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1555

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-785
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8163   -1.7466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0416   -1.7466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 18 19  1  0  0  0  0
 12 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-785

>  <JC_XSMILES>
CCOC(=O)C1=CC=CC(=C1)N2C(N)=NC(N)=NC2(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1477

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-786
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    4.3613   -0.3918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6601    0.0428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5995    0.8656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2295    1.3982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0833    2.2101    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0058    1.1189    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6358    1.6515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4121    1.3722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0422    1.9048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8184    1.6255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9647    0.8135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3346    0.2809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5584    0.5602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7983    1.0622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3637    0.3610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8963   -0.2691    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391    0.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1045   -0.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2799   -0.2887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1101    0.4383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3245    1.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1491    1.1137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5837    1.8150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1937    2.5420    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6283    3.2432    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.3296    2.8086    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9271    3.6778    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0629    3.9445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6729    4.6715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1075    5.3727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9321    5.3470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3668    6.0482    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.3221    4.6199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8875    3.9187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4083    1.7892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  3 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  2  0  0  0  0
 25 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 33 34  4  0  0  0  0
 28 34  4  0  0  0  0
 23 35  4  0  0  0  0
 14 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-786

>  <JC_XSMILES>
CC1=C(C(=O)OCC2=CC=CC=C2)C3=C(O1)C4=CC=CC=C4C(NS(=O)(=O)C5=CC=C(F)C=C5)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.432

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-789
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    2.0720    5.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8567    5.2550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0282    6.0620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8128    6.3170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4259    5.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2544    4.9580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8675    4.4059    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6744    4.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0869    3.8630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8406    3.5274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7544    2.7069    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.5794    2.7069    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8406    1.8865    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9474    2.5354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5349    3.2499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4697    4.7030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2982    3.8960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
  6 29  4  0  0  0  0
  2 29  4  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-789

>  <JC_XSMILES>
CC1=CC=CC(N2N=C3CS(=O)(=O)CC3=C2NC(=O)C4=CC=C5OCOC5=C4)=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1243

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.034482759

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-791
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5986   -3.9898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7479   -5.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9275   -5.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4425   -4.8297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7781   -4.0760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  8  7  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  2  0  0  0  0
 11 15  2  0  0  0  0
 15 16  1  4  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-791

>  <JC_XSMILES>
CC1=CC=CC=C1C=C2SC(NC2=O)=NC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.058

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-792
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    1.4289   -7.4250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  8  7  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 27 28  1  0  0  0  0
 16 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 13 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-792

>  <JC_XSMILES>
ClC1=CC=CC=C1C=CC(=O)NC2=CC=C(OC3=CC=C4C=CC=CC4=C3Cl)C(Cl)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.034

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-794
  Mrv1591402191617072D          

 44 51  0  0  0  0            999 V2000
    2.8353   -0.8278    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804   -0.0431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804    1.2917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353    2.0764    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0653    0.6243    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8903    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5403   -0.8046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278   -1.5191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028   -1.5191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8903   -0.8046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    3.9243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2875    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1125    0.6243    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -2.6757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  4 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
  3 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 24 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 31 38  2  0  0  0  0
 15 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 39 44  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-794

>  <JC_XSMILES>
O=C1C2C(C(=O)N1CC3=CC=CC=C3)C5(C4=CC=CC=C4)C(=O)C2(C6=CC=CC=C6)C(C7=CC=CC=C7)=C5C8=CC=CC=C8

>  <PF proliferation inhibition 3D7 EC50 uM>
0.822

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-795
  Mrv1591402191617072D          

 47 54  0  0  0  0            999 V2000
    6.3653    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5403    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8903    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028    1.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278    1.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5403    2.0532    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.3653    2.0532    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.1278    2.7677    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0653    0.6243    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804   -0.0431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353   -0.8278    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804    1.2917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353    2.0764    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    3.9243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2875    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1125    0.6243    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -2.6757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 18 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 14 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 27 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 35 40  4  0  0  0  0
 34 41  2  0  0  0  0
 18 41  1  0  0  0  0
 41 42  1  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 42 47  4  0  0  0  0
M  CHG  2   8   1   9  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-795

>  <JC_XSMILES>
CC1=CC=C(C=C1[N+]([O-])=O)N2C(=O)C3C(C2=O)C5(C4=CC=CC=C4)C(=O)C3(C6=CC=CC=C6)C(C7=CC=CC=C7)=C5C8=CC=CC=C8

>  <PF proliferation inhibition 3D7 EC50 uM>
0.822

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-799
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
    4.2868    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -5.4349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -6.2195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -5.4349    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -6.8870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8671   -7.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3822   -8.3081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4383   -8.2219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9232   -8.8893    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5877   -9.6430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2328   -9.7292    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0726  -10.3104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7371  -11.0641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2220  -11.7315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0425  -11.6453    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3780  -10.8916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8931  -10.2242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2287   -9.4705    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.7437   -8.8031    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.0491   -9.3843    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7739   -7.4682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2890   -6.8007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  2  0  0  0  0
 27 40  4  0  0  0  0
 40 41  4  0  0  0  0
 24 41  4  0  0  0  0
M  CHG  4   1  -1   2   1  37   1  38  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-799

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C3=NN=C(O3)C4=CC=C(NC(=O)C5=CC=CC=C5[N+]([O-])=O)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.406

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-80
  Mrv1591402191617072D          

 42 46  0  0  1  0            999 V2000
    0.4917   -3.1816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2228   -2.7691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9373   -3.1816    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2228   -1.9441    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -0.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -0.1923    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -0.3758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8843    0.2692    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7279   -1.1191    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.5529   -1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9654   -0.4047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5529    0.3098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9654    1.0243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7904    1.0243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2029    1.7387    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2029    0.3098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7904   -0.4047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -1.8624    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8843   -2.5075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5829   -3.2754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0973   -3.9204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7959   -4.6884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9801   -4.8114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4657   -4.1664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7671   -3.3984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7001   -2.3845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0015   -1.6165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2145   -3.0295    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0303   -2.9065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5447   -3.5516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3604   -3.4286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8748   -4.0736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5734   -4.8416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7576   -4.9645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2433   -4.3195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -2.0460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3821   -2.8503    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 12 10  1  0  0  0  0
 12 13  1  6  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 22 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
 21 39  1  0  0  0  0
 39 40  2  0  0  0  0
 39 41  1  0  0  0  0
  8 41  4  0  0  0  0
 41 42  4  0  0  0  0
  5 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-80

>  <JC_XSMILES>
CC(=O)NC1=CC=C2NC(=O)[C@H](CC3=CC=C(O)C=C3)N(C(C4CCCCC4)C(=O)NCC5=CC=CC=C5)C(=O)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.807

>  <W2 Pf proliferation inhibition EC50 uM>
0.555

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.659

>  <Powder data?>
No

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-802
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 11 17  4  0  0  0  0
  6 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
M  CHG  2  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-802

>  <JC_XSMILES>
OC(=O)C1=CC(=CC=C1OC2=CN=CC(Cl)=C2)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0333

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-805
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8245   -4.0962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4372   -3.4254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
 16 17  1  0  0  0  0
 10 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-805

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)N2C(N)=NC(N)=NC2(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01879

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-810
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    7.0714   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -0.5396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569    1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-810

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C(=O)NC2=CC3=NSN=C3C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.249

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.042253521

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-811
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 15 21  4  0  0  0  0
 12 22  4  0  0  0  0
  8 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-811

>  <JC_XSMILES>
OC1=CC=C(C=C1)C2=CN=CC(NCC3=CC=CC(O)=C3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.626

>  <W2 Pf proliferation inhibition EC50 uM>
1.248

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-812
  Mrv1591402191617072D          

 35 40  0  0  0  0            999 V2000
   -6.4110   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9985   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1735   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7610   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9360   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5235   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9360   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7610   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6985   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2136   -1.3951    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8860    2.0445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065    2.1307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0420    1.3770    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190    2.8452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065    3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190    4.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9440    4.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3565    4.9886    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9440    5.7031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3565    3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9440    2.8452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2136   -2.7299    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
 20 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  4  0  0  0  0
 24 31  4  0  0  0  0
 13 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 11 34  4  0  0  0  0
 34 35  4  0  0  0  0
  9 35  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  35
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-812

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=NC3=CC(CC4=CC=C5NC(=NC5=C4)C6=CC=C(OC)C=C6)=CC=C3N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2335

>  <W2 Pf proliferation inhibition EC50 uM>
0.775

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.22

>  <Powder data?>
Yes

>  <IFI value>
0.257142857

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-816
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    8.5737    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9151    1.2330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1081    1.4045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6956    0.6900    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2476    0.0769    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0761   -0.7300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6892   -1.2821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5177   -2.0890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7330   -2.3440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5615   -3.1509    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.1199   -1.7919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2915   -0.9850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7725    2.1582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4370    2.9119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0189    1.8226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5262    2.4937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 11 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  4 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 27 36  4  0  0  0  0
 31 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-816

>  <JC_XSMILES>
CC(C)N(CC(=O)NC1=CC(=NN1C2=CC=C(Cl)C=C2)C(C)(C)C)C(=O)C3=CC=CC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
1.208

>  <W2 Pf proliferation inhibition EC50 uM>
>1.237

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009803922

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-817
  Mrv1591402191617072D          

 15 15  0  0  0  0            999 V2000
    1.9967    1.9393    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2822    2.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5678    1.9393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1467    2.3518    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5678    1.1143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2352    0.6294    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9803   -0.1553    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.1553   -0.1553    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0997    0.6294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8843    0.8843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4974    0.3323    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0558    1.6913    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2822    3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5678    3.5893    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9967    3.5893    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
  2 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-817

>  <JC_XSMILES>
OC(C(O)C1=NSN=C1C(O)=O)C(O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.408

>  <W2 Pf proliferation inhibition EC50 uM>
>1.236

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-818
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -2.9646    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    8.0652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    9.3027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    9.3027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    7.2402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    4.7652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1331    3.0428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8781    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0531    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7982    3.0428    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    7.2402    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067   10.5402    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.6078   10.9527    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.8212   10.9527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  9  8  1  4  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 15 24  4  0  0  0  0
 11 24  4  0  0  0  0
  8 25  4  0  0  0  0
  4 25  4  0  0  0  0
 25 26  1  0  0  0  0
  6 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  2  0  0  0  0
M  CHG  2  27   1  28  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-818

>  <JC_XSMILES>
CCOC1=CC(=CC(C=NC2=CC=CC(NC(=O)C3=CC=CO3)=C2)=C1O)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.236

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-821
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
  3 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  2  0  0  0  0
 28 30  4  0  0  0  0
 19 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-821

>  <JC_XSMILES>
CCC(N(CC)C(=O)C1=CC=C2C=CC=CC2=C1)C3=NC4=CC(Cl)=CC=C4C(=O)N3CC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.22

>  <W2 Pf proliferation inhibition EC50 uM>
1.232

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-822
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3832   -6.2599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -7.0445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3033   -7.0445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0483   -6.2599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
  8 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  6 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-822

>  <JC_XSMILES>
CC(C)CNC1=NC(NCCCN2CCCC2)=NC=C1C(=O)NCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.664

>  <W2 Pf proliferation inhibition EC50 uM>
>1.231

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-824
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    4.1912    1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5414    0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3515    0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8916    0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7017    0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9718    1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7819    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3220    0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4317    1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6216    1.5493    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0815    2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2713    2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7313    2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8114    3.5762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3515    2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1617    3.1084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4317    3.8880    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7017    2.4848    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5119    2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0520    2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8621    2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1321    2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5921    3.5762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7819    3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2418    4.0439    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5119    4.8234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2418   -0.3216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0520   -0.1657    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9718   -1.1012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5119   -1.7248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2418   -2.5043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4317   -2.6603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1617   -3.4398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3515   -3.5957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8114   -2.9721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0815   -2.1925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8916   -2.0366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1617   -1.2571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
  6 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 39 40  4  0  0  0  0
 31 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-824

>  <JC_XSMILES>
CCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3OC)C(=O)C4=CC=C5C=CC=CC5=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.752

>  <W2 Pf proliferation inhibition EC50 uM>
>1.228

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-827
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -4.8395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.4105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 21 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 18 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-827

>  <JC_XSMILES>
CN1CCN(CC1)S(=O)(=O)C2=CC(=CC=C2C)C3=NN=C(N4CCOCC4)C5=CC=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.222

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-829
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    1.9878   -3.3762    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489   -2.2111    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227   -3.3151    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6073    2.1742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2204    1.6222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 14  1  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  7 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-829

>  <JC_XSMILES>
FC(F)(F)C(=O)C1=CN(C(=O)C2CC2)C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
1.367

>  <W2 Pf proliferation inhibition EC50 uM>
>1.221

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.015384615

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-835
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572   -0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.7322    0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
 25 31  4  0  0  0  0
 31 32  4  0  0  0  0
 22 32  4  0  0  0  0
 17 33  4  0  0  0  0
 13 33  4  0  0  0  0
 33 34  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-835

>  <JC_XSMILES>
CCOC(=O)C(C)OC1=CC=CC2=C1C=CN(CC(=O)NC3=CC=C(OC(F)(F)F)C=C3)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.218

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-837
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    5.0013   -1.2375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
  6 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  CHG  4   1  -1   2   1  10   1  11  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-837

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(=CC(=C1)[N+]([O-])=O)C(=O)NC2CCN(CC2)CC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.476

>  <W2 Pf proliferation inhibition EC50 uM>
1.218

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.015037594

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-839
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.8997    1.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0927    1.6501    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4593    1.0370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2663    1.2085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8183    0.5954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5633   -0.1892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7563   -0.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2043    0.2524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1153   -0.8023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6674   -0.1893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4743   -0.3608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0264    0.2522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8334    0.0807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0883   -0.7040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5362   -1.3170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7293   -1.1455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4479   -1.2872    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7028   -2.0719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2178   -2.7393    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5278   -2.0719    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7827   -1.2873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5674   -1.5423    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  9 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
  9 21  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-839

>  <JC_XSMILES>
COC1=CC=C(C=C1)C3(CC2=CC=CC=C2)NC(=O)NC3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.339

>  <W2 Pf proliferation inhibition EC50 uM>
>1.217

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-840
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  2  0  0  0  0
 16 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-840

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1OC)\C=C2/SC(=NC2=O)C3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.217

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-85
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7565    0.1395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4209    0.8932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6005    0.8070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  1  0  0  0  0
  9 22  4  0  0  0  0
  2 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-85

>  <JC_XSMILES>
CC1=NC2=NC=NN2C(NC3=CC4=CC=CC=C4C=C3O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.345

>  <W2 Pf proliferation inhibition EC50 uM>
1.292

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.754

>  <Powder data?>
Yes

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-851
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 15 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 30 35  1  0  0  0  0
 27 36  4  0  0  0  0
 12 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-851

>  <JC_XSMILES>
CC1CCCCN1CCCNC2=NC=C(C(=O)NCCC3=CC=CC=C3)C(NCC4CCCCC4)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.602

>  <W2 Pf proliferation inhibition EC50 uM>
1.201

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-853
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    1.7605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-853

>  <JC_XSMILES>
CC(CCCC(C)(C)O)NC1=CN=CC(=N1)C2=CC=C(C=C2)C(N)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.199

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-854
  Mrv1591402191617072D          

 36 41  0  0  0  0            999 V2000
   -9.8591    2.7691    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -9.1446    3.1816    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -9.1446    4.0066    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4302    2.7691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7157    3.1816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0012    2.7691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0012    1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7157    1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4302    1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2868    1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2868    0.7066    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5723    1.9441    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8578    1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1434    1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4289    1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4289    0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1434    0.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8578    0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7144    0.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9607    0.6296    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6282   -0.5264    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 19 27  4  0  0  0  0
 23 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 35 36  4  0  0  0  0
 28 36  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  STY  1   1 DAT
M  SAL   1  1  27
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-854

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)C3=NC4=CC(=CC=C4N3)C5=NC6=CC=CC=C6O5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.049

>  <W2 Pf proliferation inhibition EC50 uM>
1.199

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-855
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    2.7512    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    2.0009    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0284   -2.0811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1431   -2.8881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4700   -3.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2546   -3.1852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4262   -2.3782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8131   -1.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4888   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1019   -2.0811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8865   -1.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4996   -2.3782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3281   -3.1852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5434   -3.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9303   -2.8881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 11 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
  9 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
  6 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-855

>  <JC_XSMILES>
CCN(CC)C1=CC=C(C2N(CCN2CC3=CC=CC=C3)CC4=CC=CC=C4)C(O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.361

>  <W2 Pf proliferation inhibition EC50 uM>
2.822

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.56

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-857
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
   -3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
  5 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 39 40  4  0  0  0  0
  3 40  4  0  0  0  0
M  CHG  2  31   1  32  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-857

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=CC=C2OC)C(=O)C3=CC=C(C)C(=C3)[N+]([O-])=O)=C4N=CC=CC4=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.873

>  <W2 Pf proliferation inhibition EC50 uM>
0.555

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.64

>  <Powder data?>
No

>  <IFI value>
0.018348624

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-859
  Mrv1591402191617072D          

 29 30  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1118   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4618   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -4.6480    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -6.0770    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
  5 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  3 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-859

>  <JC_XSMILES>
COC1=CC(NC(=O)C(F)(F)F)=C(C=C1OC)C(=O)C2=CC=C(C=C2)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.135

>  <W2 Pf proliferation inhibition EC50 uM>
>1.196

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019607843

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-86
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    4.9279   -2.1896    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6260   -1.0626    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8010   -2.4915    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
  9 28  4  0  0  0  0
  5 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-86

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(NC2=NC3=NON=C3N=C2NC4=CC=C(Br)C=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
7.62

>  <W2 Pf proliferation inhibition EC50 uM>
5.2

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.13

>  <Powder data?>
Yes

>  <IFI value>
0.222222222

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-863
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -3.6020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.1730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 14 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-863

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)S(=O)(=O)OC2=CC=CC3=CC=CN=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.694

>  <W2 Pf proliferation inhibition EC50 uM>
>1.194

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-865
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    3.4166    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    4.3727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    4.9858    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5614    5.7928    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2759    6.2053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8889    5.6533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5534    4.8996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  2  0  0  0  0
  3  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
  9 19  4  0  0  0  0
 19 20  4  0  0  0  0
  7 20  4  0  0  0  0
  8 21  4  0  0  0  0
  2 21  4  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-865

>  <JC_XSMILES>
CN1C(=O)N(C)C2=C(N(CC(O)CN3CCCC3)C=N2)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.194

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.042735043

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-868
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    5.0013    3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0032   -5.3493    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3390   -2.3346    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  9  8  1  4  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 20 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
 28 29  1  0  0  0  0
  8 30  4  0  0  0  0
  4 30  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-868

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(C=NNC(=N)SC2CC(=O)N(C2=O)C3=CC(Cl)=CC=C3Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.193

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-869
  Mrv1591402191617072D          

 17 16  0  0  0  0            999 V2000
    2.1434    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2539    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.4289    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
   -0.8250    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    2.8579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.6039    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    1.4289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  5 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
M  CHG  1   5   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-869

>  <JC_XSMILES>
CCCN[P+](CC(C)C)(NCCC)NCCC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2109

>  <W2 Pf proliferation inhibition EC50 uM>
0.398

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.34

>  <Powder data?>
Yes

>  <IFI value>
0.109090909

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-873
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -1.5246   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -0.8802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -1.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -1.3480    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    0.0552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9058   -0.1007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3657    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444    0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9845    0.9907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.7702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0957    1.9262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358    1.3025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459    1.4584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    2.2380    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860    0.8348    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961    0.9907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362    0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164    1.3025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763    1.9262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662    1.7702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261    2.3939    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961    3.1734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261   -1.9716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -1.8157    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -2.7512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961   -3.3748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261   -4.1543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -4.3103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459   -5.0898    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -3.6866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459   -2.9071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
  6 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 31 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-873

>  <JC_XSMILES>
CCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3OC)C(=O)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.878

>  <W2 Pf proliferation inhibition EC50 uM>
1.05

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.82

>  <Powder data?>
No

>  <IFI value>
0.01

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-874
  Mrv1591402191617072D          

 25 29  0  0  0  0            999 V2000
    0.2688    1.8302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0932    1.8009    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5308    2.5004    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1438    3.2290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5814    3.9284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4059    3.8992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7928    3.1706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3553    2.4712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7422    1.7425    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5667    1.7133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0042    2.4127    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9536    0.9847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5161    0.2853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0461   -0.3470    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.8112   -0.0383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7540    0.7847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5191    1.0934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0491    0.4611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6115   -0.2383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6916    0.3145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1182   -0.2787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2611   -1.0912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3769    0.0833    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4921    0.9003    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3047    1.0431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  1  0  0  0  0
 13 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
  9 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-874

>  <JC_XSMILES>
COC1=CC=CC=C1N2C(=O)C3=C(SC4=C3CCC4)N5C(C)=NN=C25

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.19

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-877
  Mrv1591402191617072D          

 36 37  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1763   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8263   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 14 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 26 29  4  0  0  0  0
 29 30  4  0  0  0  0
 23 30  4  0  0  0  0
 11 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
 33 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-877

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(=O)C(CCC(CNC(C)(C)C)C(=O)C2=CC=C(OC)C=C2)CNC(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.121

>  <W2 Pf proliferation inhibition EC50 uM>
1.189

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-878
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 12 19  4  0  0  0  0
 19 20  4  0  0  0  0
  9 20  4  0  0  0  0
  5 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
  3 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-878

>  <JC_XSMILES>
COC1=CC(CN(C)C2=CC=C3N=C(N)N=C(N)C3=C2)=CC(OC)=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00731

>  <W2 Pf proliferation inhibition EC50 uM>
1.189

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-879
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -0.9355    0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2210   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2211   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9356   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3645   -2.0624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0790   -2.4749    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3340   -3.2595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1410   -3.4310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3959   -4.2156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8439   -4.8287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0369   -4.6572    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7820   -3.8726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7770   -1.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6020   -1.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0145   -0.6334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6019    0.0810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7769    0.0810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3645   -0.6335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9520   -2.7769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7146   -3.4915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1271   -4.2059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9521   -4.2059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3646   -3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  8 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  8 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-879

>  <JC_XSMILES>
ClC1=CC=CC(=C1)C(NC2=CC=CN=C2)(C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.618

>  <W2 Pf proliferation inhibition EC50 uM>
1.188

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-881
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
    0.5942    2.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0422    2.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2971    1.3977    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2549    0.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0619    0.9561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7224   -1.3819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5474   -1.3819    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -2.0964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7224   -2.8109    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -3.5253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4894   -3.6116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3179   -4.4185    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0324   -4.8310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1186   -5.6515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8723   -5.9871    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9585   -6.8075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7122   -7.1431    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2911   -7.2925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5374   -6.9569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1300   -7.4418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0438   -8.2623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7099   -8.5979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7961   -9.4184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3773   -8.1130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6455   -4.2790    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4525   -4.4505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7074   -5.2351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5144   -5.4067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0664   -4.7936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8115   -4.0090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3635   -3.3959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0045   -3.8374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3349    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 21 27  4  0  0  0  0
 16 28  4  0  0  0  0
 13 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 29 35  4  0  0  0  0
  7 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
  6 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 37 41  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-881

>  <JC_XSMILES>
CCOC(=O)C1=C(NC(=O)CSC2=NN=C(CNC(=O)C3=CC=CC(C)=C3)N2C4=CC=CC(C)=C4)SC5=C1CCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.595

>  <W2 Pf proliferation inhibition EC50 uM>
>1.187

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.023255814

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-882
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    1.3222   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -3.7741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -4.2590    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -5.0437    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -5.0437    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -4.2590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4888   -4.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1019   -4.5561    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8865   -4.3012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4996   -4.8532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3281   -5.6602    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5434   -5.9151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9303   -5.3631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9411   -6.2122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7258   -5.9573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3389   -6.5093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1673   -7.3163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3827   -7.5712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7696   -7.0192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9850   -7.2741    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-882

>  <JC_XSMILES>
CC(C)N1N=NN=C1CN2CCN(CC2)C3=CC=CC=C3F

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.477

>  <W2 Pf proliferation inhibition EC50 uM>
>1.187

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.016666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-883
  Mrv1591402191617072D          

 36 38  0  0  0  0            999 V2000
   -7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 12 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 10 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
  6 33  4  0  0  0  0
 33 34  4  0  0  0  0
  3 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-883

>  <JC_XSMILES>
COC1=CC=C(CCNC2=NC(NCCCN(C)C)=NC=C2C(=O)NCC3=CC=CC=C3)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.605

>  <W2 Pf proliferation inhibition EC50 uM>
>1.187

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-884
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -8.2500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7550   -4.2019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3070   -4.8150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8945   -5.5295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0875   -5.3580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4744   -5.9100    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 21 25  1  0  0  0  0
 25 26  2  0  0  0  0
 14 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 27 37  4  0  0  0  0
 11 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-884

>  <JC_XSMILES>
COC1=CC=CC=C1CNC2=NC=C(C(=O)NCCCN3CCCC3=O)C(NCCC4=CC=CC=C4)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2136

>  <W2 Pf proliferation inhibition EC50 uM>
1.187

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019417476

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-885
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    2.8579   -4.9500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -1.4924    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8419   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -0.1576    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  4  0  0  0  0
 22 23  4  0  0  0  0
 10 23  1  0  0  0  0
 15 23  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-885

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(=C1)C2CC(=O)NC3=CC4=C(OCO4)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
>10.19

>  <W2 Pf proliferation inhibition EC50 uM>
>11.85

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.04

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-886
  Mrv1591402191617072D          

 12 13  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  2  0  0  0  0
  7  9  4  0  0  0  0
  4  9  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
 11 12  1  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1   9
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-886

>  <JC_XSMILES>
ClC1=CC2=C(NC(=O)N2)N=C1Br

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.184

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-889
  Mrv1591402191617072D          

 33 36  0  0  1  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4647   -4.0640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3199   -4.3189    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4915   -5.1259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1216   -5.6779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9063   -5.4230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0778   -4.6160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0339   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8186   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9901   -2.4922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3770   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5924   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -4.3257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4824   -3.5721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6318   -4.9932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4522   -4.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9372   -5.5744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6016   -6.3281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7811   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2962   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4757   -5.8331    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  5  3  1  6  0  0  0
  5  6  1  0  0  0  0
  7  6  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 11 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  7 24  1  1  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-889

>  <JC_XSMILES>
COC(=O)[C@@H]1C[C@H](CN1CC(C2=CC=CC=C2)C3=CC=CC=C3)NC(=O)C4=CC=CC=C4F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.065

>  <W2 Pf proliferation inhibition EC50 uM>
>1.182

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.026785714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-892
  Mrv1591402191617072D          

 21 21  0  0  0  0            999 V2000
    2.1434    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
 12 13  1  4  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-892

>  <JC_XSMILES>
COC(=O)N(C)C(C)(C)C(C)=NOC(=O)C1=CC=CC=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.619

>  <W2 Pf proliferation inhibition EC50 uM>
>1.177

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-893
  Mrv1591402191617072D          

 20 23  0  0  0  0            999 V2000
   -0.2203   -0.8765    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.6043   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9943   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8189   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2535   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0781   -0.7735    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6108   -0.1434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3745   -0.4553    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3140   -1.2781    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -1.4747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1228   -2.2017    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2982   -2.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9082   -2.9545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3428   -3.6557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9528   -4.3827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1282   -4.4085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6936   -3.7073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0836   -2.9802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8636   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0390   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 12 19  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
  2 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-893

>  <JC_XSMILES>
ClC1=CC=C2N3N=NN=C3N=C(C4=CC=CC=C4)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.177

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.030769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-894
  Mrv1591402191617072D          

 41 46  0  0  0  0            999 V2000
   -0.8123    2.7643    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.8123    1.9393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0978    1.5268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0978    0.7018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8123    0.2893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5268    0.7018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5268    1.5268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8123   -0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1449   -1.0206    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3998   -1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2248   -1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4798   -1.0206    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7097   -2.4727    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5302   -2.3865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0151   -3.0539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6796   -3.8076    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8356   -2.9677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3205   -3.6351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1410   -3.5489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4766   -2.7952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9917   -2.1278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1712   -2.2140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0851   -2.4727    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
    0.5700   -3.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3905   -3.0539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8754   -3.7213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5399   -4.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7194   -4.5612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2345   -3.8938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5823   -2.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4961   -3.7781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1635   -4.2630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9172   -3.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0034   -3.1070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3360   -2.6221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7525   -1.9878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6663   -1.1673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3337   -0.6824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0874   -1.0179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1737   -1.8384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5062   -2.3233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 10 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 23 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 23 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 36 41  4  0  0  0  0
M  CHG  1  23   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-894

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C2=NC(=C(O2)SCC(=O)C3=CC=CC=C3)[P+](C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.851

>  <W2 Pf proliferation inhibition EC50 uM>
>1.177

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.214285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-895
  Mrv1591402191617072D          

 17 17  0  0  0  0            999 V2000
   -1.4289    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    1.7605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    3.1895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-895

>  <JC_XSMILES>
CCOP(=O)(OCC)C(O)C1=CC=C(C)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.176

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-898
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    5.4957    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.0146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.8396    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 14 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
 26 30  4  0  0  0  0
 11 30  4  0  0  0  0
 30 31  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-898

>  <JC_XSMILES>
COC1=CC(OC)=CC(=C1)N2C(=O)N(CC(=O)C3=CC=C(F)C=C3)C4=C(SC=C4)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.173

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019607843

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-899
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 13 21  4  0  0  0  0
 21 22  2  0  0  0  0
 21 23  4  0  0  0  0
  9 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-899

>  <JC_XSMILES>
CCCNC(=O)CSC1=NC(C)=C(CC2=CC=CC=C2)C(=O)N1C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.279

>  <W2 Pf proliferation inhibition EC50 uM>
1.172

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009259259

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-90
  Mrv1591402191617072D          

 54 58  0  0  0  0            999 V2000
    3.9497    0.4670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7744    0.4919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2082   -0.2098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9491    0.1531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7465    0.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9736   -0.4286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7981   -0.4577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0806    0.3174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4307    0.8256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1681    0.0393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4804    0.8029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8815   -0.3751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3637    0.2943    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.5003   -0.9206    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.0008   -1.5765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7025   -1.1426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3638   -2.3173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5752   -3.1148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3503   -3.3973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3212   -4.2218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5280   -4.4488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0670   -3.7647    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.2500   -5.5363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0136   -5.8487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8356   -6.2497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5049   -6.7320    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.2900   -6.8686    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.6342   -7.3691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0680   -8.0708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8926   -8.0460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8933   -7.7320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0959   -7.9435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8134   -8.7186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9889   -8.6895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7618   -7.8963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4460   -7.4353    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6743   -7.6182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3620   -8.3818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9609   -7.2039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4786   -7.8732    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3421   -6.6583    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8416   -6.0025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1398   -6.4363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4786   -5.2616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2672   -4.4641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4921   -4.1816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5212   -3.3572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3143   -3.1301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7754   -3.8143    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5924   -2.0426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8288   -1.7303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0068   -1.3292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3374   -0.8469    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5524   -0.7104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 32 36  1  0  0  0  0
 35 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  1  0  0  0  0
 39 40  2  0  0  0  0
 39 41  1  0  0  0  0
 41 42  1  0  0  0  0
 42 43  1  0  0  0  0
 42 44  1  0  0  0  0
 44 45  1  0  0  0  0
 45 46  1  0  0  0  0
 46 47  1  0  0  0  0
 47 48  1  0  0  0  0
 48 49  1  0  0  0  0
 45 49  1  0  0  0  0
 48 50  1  0  0  0  0
 50 51  1  0  0  0  0
 50 52  1  0  0  0  0
 52 53  2  0  0  0  0
 52 54  1  0  0  0  0
  3 54  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-90

>  <JC_XSMILES>
CCC1CC2CCC(O2)C(C)C(=O)OC(C)CC3CCC(O3)C(C)C(=O)OC(CC)CC4CCC(O4)C(C)C(=O)OC(C)CC5CCC(O5)C(C)C(=O)O1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1619

>  <W2 Pf proliferation inhibition EC50 uM>
0.2281

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.356

>  <Powder data?>
No

>  <IFI value>
0.240740741

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-900
  Mrv1591402191617072D          

 18 18  0  0  0  0            999 V2000
    0.0000    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-900

>  <JC_XSMILES>
CCN(CC)S(=O)(=O)C1=CC(=CC=C1Cl)C(O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.64

>  <W2 Pf proliferation inhibition EC50 uM>
>1.172

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.079365079

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-901
  Mrv1591402191617072D          

 39 43  0  0  1  0            999 V2000
   -0.8212   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067   -1.7116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -2.9491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -3.7741    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.7041   -4.2590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -5.0437    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6242   -5.0437    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -4.2590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -5.7111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -5.6249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1661   -6.2923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9866   -6.2061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -5.4524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8372   -4.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0168   -4.8712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4682   -4.2037    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -5.7111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7546   -5.6249    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5986   -6.4648    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -7.1322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7479   -7.8859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9275   -7.9721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4425   -7.3047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7781   -6.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5919   -8.7258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0768   -9.3932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7413  -10.1469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9208  -10.2331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4359   -9.5657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7714   -8.8120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3846   -9.6519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2051   -9.7382    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4709   -8.8315    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2984  -10.4724    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  8  1  6  0  0  0
  9 10  1  0  0  0  0
 11 10  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 11 22  1  1  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
 27 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 36 38  1  0  0  0  0
 36 39  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-901

>  <JC_XSMILES>
CN1CCC(CC1)N[C@@H]2C[C@H](N(C2)CC3=CC=CC=C3Cl)C(=O)N4CCN(CC4)C5=CC=CC(=C5)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.171

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.01

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-905
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 21 22  1  0  0  0  0
 11 23  4  0  0  0  0
 23 24  4  0  0  0  0
  8 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 27 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-905

>  <JC_XSMILES>
CC(C)CNC(=O)C1=CN=C(NCCCN2CCCCC2C)N=C1NCC3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.434

>  <W2 Pf proliferation inhibition EC50 uM>
1.167

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-907
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    6.4302   -2.0625    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.3033   -5.0605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -6.4895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 13 24  4  0  0  0  0
 24 25  4  0  0  0  0
 10 25  4  0  0  0  0
  5 26  4  0  0  0  0
 26 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-907

>  <JC_XSMILES>
BrC1=CC=C(NS(=O)(=O)C2=CC=C(NC(=O)NC3=CC=CC=C3)C=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.662

>  <W2 Pf proliferation inhibition EC50 uM>
1.163

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-908
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    8.4488    2.5720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9344    1.9270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1187    2.0499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6043    1.4049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7885    1.5279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4871    2.2958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0015    2.9409    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8172    2.8179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6713    2.4188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3699    3.1868    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1569    1.7738    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5149    1.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1569    0.2872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3526    0.1036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7076    0.6180    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9230    0.3631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4380    1.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9230    1.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7076    1.4430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3526    1.9574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1690    2.7617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3807    3.0049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1971    3.8092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8019    4.3703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5902    4.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7738    3.3228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6183    5.1746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4347    5.9789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4226    5.3582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8140    4.9911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 19 20  1  0  0  0  0
 11 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-908

>  <JC_XSMILES>
CCC1=CC=C(C=C1)C(=O)N2CCCN3C=CC=C3C2C4=CC=C(C=C4)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.161

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.075268817

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-909
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
    5.0013    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  3  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  5 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  3 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  3  0  0  0  0
 12 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  3  0  0  0  0
 25 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 23 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 28 37  1  0  0  0  0
 37 38  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-909

>  <JC_XSMILES>
N#CC1=NC(C2=CC=CC=C2)=C(N=C1C#N)C3=CC=C(C=C3)C4=NC(C#N)=C(N=C4C5=CC=CC=C5)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
1.612

>  <W2 Pf proliferation inhibition EC50 uM>
1.159

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-910
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   10.7570   -4.5888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9320   -4.5888    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.5195   -3.8743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6945   -3.8743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2820   -3.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6945   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2820   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4570   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0445   -1.0164    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2195   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8070   -1.7309    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2195    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0445    0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445    0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.5195   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9320   -3.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7570   -3.1599    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.1695   -3.8743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 25 31  1  0  0  0  0
  6 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-910

>  <JC_XSMILES>
COC1=CC=C(CCNC(=O)C2=CC(=CC=C2F)S(=O)(=O)N3CCC4(CC3)OCCO4)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.159

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.023255814

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-913
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-913

>  <JC_XSMILES>
COC1=CC=CC=C1\C=C\CN2CCN(CC2)C3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.629

>  <W2 Pf proliferation inhibition EC50 uM>
>1.151

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-914
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -5.0013    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599    1.3480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9849    2.7770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
  3 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 20 29  4  0  0  0  0
 29 30  2  0  0  0  0
 29 31  4  0  0  0  0
 17 31  4  0  0  0  0
 31 32  4  0  0  0  0
 14 32  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-914

>  <JC_XSMILES>
CCN(C1=CC=C(F)C=C1)S(=O)(=O)C2=CC=C3NC=C(C(=O)NCCC(C)C)C(=O)C3=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.151

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-915
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 11 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-915

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2N3N=CN=C3NC(C)=C2C(N)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.38

>  <W2 Pf proliferation inhibition EC50 uM>
1.151

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-919
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
  3 11  4  0  0  0  0
  1 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  11
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-919

>  <JC_XSMILES>
C(SC1=NC2=CC=NC=C2N1)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.15

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-921
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    5.5388   -3.5308    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.8244   -3.1183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2369   -2.4038    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.4119   -3.8328    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.1099   -2.7058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3954   -3.1183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6809   -2.7058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6809   -1.8808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3954   -1.4683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1099   -1.8808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8244   -1.4683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5388   -1.8808    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2533   -1.4683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2533   -0.6433    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9678   -1.8808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6822   -1.4683    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6822   -0.6433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9678   -0.2308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9678    0.5942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6822    1.0067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3967    0.5942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3967   -0.2308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1112   -0.6433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1112   -1.4683    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.8545   -1.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0381   -2.6306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5237   -3.2756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6987   -3.2756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1843   -2.6306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3679   -1.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6822    1.8317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9678    2.2442    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9678    3.0692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6822    3.4817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3967    3.0692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3967    2.2442    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 24 30  1  0  0  0  0
 20 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-921

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC=C1CNC(=O)COC2=CC=C(C=C2CN3CCCCCC3)C4=NC=CC=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.146

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028037383

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-925
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  3 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  2  0  0  0  0
 31 33  4  0  0  0  0
 23 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  1  0  0  0  0
 37 39  4  0  0  0  0
 39 40  4  0  0  0  0
 34 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-925

>  <JC_XSMILES>
CCC(N(CCC1=CC=CC=C1)C(=O)COC2=CC=CC=C2)C3=NC4=CC=CC=C4C(=O)N3C5=CC=C(F)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.026

>  <W2 Pf proliferation inhibition EC50 uM>
1.145

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.010752688

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-927
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  3  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 13 22  1  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-927

>  <JC_XSMILES>
COC1=CC=C(Br)C=C1S(=O)(=O)N2CCCC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
9.95

>  <W2 Pf proliferation inhibition EC50 uM>
11.45

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015384615

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-933
  Mrv1591402191617072D          

 17 17  0  0  0  0            999 V2000
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
  2 16  4  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-933

>  <JC_XSMILES>
CC1=C(C)C(C)=C(CNC(=S)NN)C(C)=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
4.09

>  <W2 Pf proliferation inhibition EC50 uM>
>11.37

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.02020202

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-935
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -2.3020    3.6226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0470    2.8379    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8128   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4628   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.3646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 16 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
  9 36  4  0  0  0  0
  3 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-935

>  <JC_XSMILES>
COC1=CC=C(OC)C(NC(=O)C2=C3N=C(C=C(N3N=C2)C(F)(F)F)C4=CC=C(OC)C(OC)=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.136

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-936
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2309   -1.6545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0379   -1.4830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4504   -2.1975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8984   -2.8106    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.0699   -3.6175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5253   -5.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1904   -5.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 11 21  4  0  0  0  0
 21 22  4  0  0  0  0
  8 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 24 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-936

>  <JC_XSMILES>
CC(C)CNC(=O)C1=CN=C(NCCC2CCCN2C)N=C1NC3CCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.908

>  <W2 Pf proliferation inhibition EC50 uM>
1.136

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019047619

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-938
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
   -2.9362   -2.9562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8272   -2.1384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4809   -1.6351    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2723   -1.8681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7385   -1.1874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2352   -0.5337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4579   -0.8104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7773   -0.3442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0332   -0.7006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3525   -0.2345    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4159    0.5881    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6085   -0.5909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0722   -0.1247    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0525    0.6908    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5074    1.2968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3302    1.2368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7964    0.5562    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6212    0.5702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1627    1.1927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9725    1.0349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2408    0.2548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6993   -0.3677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8895   -0.2099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2305   -0.7062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5548   -0.2327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7875   -0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7276   -1.3585    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2044    2.0641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6117    2.1854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9147    2.9527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4017    3.5988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4144    3.4775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7174    2.7102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 17 25  4  0  0  0  0
 25 26  1  0  0  0  0
 13 26  1  0  0  0  0
 26 27  2  0  0  0  0
 15 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-938

>  <JC_XSMILES>
CCN1CCCC1CNC(=O)CN2N=C(CN3C4=CC=CC=C4C=C3C2=O)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.134

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-94
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    2.0367    2.8259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8617   -0.4741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2117   -0.4741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4888   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6603   -0.7221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4449   -0.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0580   -1.0192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8865   -1.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1019   -2.0811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7546   -3.1499    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5986   -3.9898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7479   -5.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9275   -5.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4425   -4.8297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7781   -4.0760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 14 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-94

>  <JC_XSMILES>
CC1=CC=C(C=C1)S(=O)(=O)N2CCN(C2C3=CC=CC=C3)C(=O)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
6.29

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.56

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-940
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    0.8928   -3.9359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4803   -3.2215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8928   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4803   -1.7925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8928   -1.0780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7178   -1.0780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1303   -0.3636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9553   -0.3636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3678   -1.0780    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3678    0.3509    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1928    0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6777    1.0183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4228    1.8030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6158    1.9745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9748    2.4160    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7199    3.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9129    3.3722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6580    4.1568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2100    4.7699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0170    4.5984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5690    5.2115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3760    5.0400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6309    4.2553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0789    3.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2719    3.8138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8913   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8913    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6777   -0.3165    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1303   -1.7925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7178   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 16 25  4  0  0  0  0
 20 25  4  0  0  0  0
 12 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
 27 32  4  0  0  0  0
 11 32  4  0  0  0  0
  6 33  4  0  0  0  0
 33 34  4  0  0  0  0
  3 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-940

>  <JC_XSMILES>
COC1=CC=C(CC(=O)NC2=C(C(=O)NC3=CC=CC4=CC=CC=C34)C5=C(CCCC5)S2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.133

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-942
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -2.5697   -6.1158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8247   -5.3312    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2726   -4.7181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5276   -3.9335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9755   -3.3204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1686   -3.4919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9136   -4.2766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4657   -4.8897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6165   -2.8788    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8715   -2.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3194   -1.4811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4875   -1.6527    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7425   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1904   -3.0504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8465   -1.2111    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -0.4849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    1.3099    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 17 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-942

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2CCN(CC2)C(=O)C3=C(C)C(=O)OC34CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.617

>  <W2 Pf proliferation inhibition EC50 uM>
>1.129

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-944
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6586    4.5330    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4656    4.7045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8781    5.4190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7031    5.4190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1156    4.7045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7031    3.9900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8781    3.9900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3260    3.3769    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
 12 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  4  0  0  0  0
 10 35  4  0  0  0  0
 35 36  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-944

>  <JC_XSMILES>
COC1=CC=C(C=C1Cl)N2N=C(C(=O)NCC(=O)NC3=NC4=CC=CC=C4S3)C5=CC=CC=C5C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.129

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.046511628

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-947
  Mrv1591402191617072D          

 38 43  0  0  0  0            999 V2000
    2.0329    0.6039    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3829   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2079   -3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954   -4.3974    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2079   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -4.3974    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8079   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579    0.6039    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  3  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
  6 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
  2 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 19 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  3  0  0  0  0
 27 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 17 32  1  0  0  0  0
 18 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 14 38  4  0  0  0  0
 33 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-947

>  <JC_XSMILES>
NC1=C(C#N)C(C2=CC=C(F)C=C2)C3=C(O1)C4=C(C(C5=CC=C(F)C=C5)C(C#N)=C(N)O4)C6=CC=CC=C36

>  <PF proliferation inhibition 3D7 EC50 uM>
4.09

>  <W2 Pf proliferation inhibition EC50 uM>
2.436

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.6

>  <Powder data?>
Yes

>  <IFI value>
0.06779661

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-948
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0392   -4.0481    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5912   -3.4350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1787   -2.7205    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6282   -2.8920    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4117   -3.5212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7473   -4.2749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5678   -4.3611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0527   -3.6937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7171   -2.9400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8966   -2.8538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  2 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-948

>  <JC_XSMILES>
O=C(CCCC1=NC(=NO1)C2=CC=CC=C2)NCC3=CC=CN=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.767

>  <W2 Pf proliferation inhibition EC50 uM>
1.127

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-951
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    4.9747    4.1844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4227    3.5713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6776    2.7867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1256    2.1736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3805    1.3890    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8956    0.7216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0706    0.7216    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6581    0.0071    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8331    0.0071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3482   -0.6604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6031   -1.4450    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5635   -0.4054    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5635    0.4196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0496    0.9716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1220    1.7786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9066    2.0335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5197    1.4815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3482    0.6745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3805    0.0541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1651    0.3091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1651    1.1341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8796    1.5466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8796    2.3716    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5941    1.1341    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5941    0.3091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3085   -0.1034    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8796   -0.1034    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8796   -0.9284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  1  0  0  0  0
 13 18  4  0  0  0  0
  6 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  5 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  2  0  0  0  0
 25 27  4  0  0  0  0
 20 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  24
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-951

>  <JC_XSMILES>
CCCCN1C(NN=C2C(=O)NC3=CC=CC=C23)=NC4=C1C(=O)NC(=O)N4C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.595

>  <W2 Pf proliferation inhibition EC50 uM>
1.126

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.013071895

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-952
  Mrv1591402191617072D          

 31 36  0  0  0  0            999 V2000
    1.4838    2.0961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6633    2.1824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3277    2.9360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8126    3.6035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6331    3.5172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9687    2.7636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9687    4.2709    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878    4.4104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5023    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5023    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2168    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9312    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7159    2.0930    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2008    2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7159    3.4279    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9312    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2168    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734    5.6479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    6.8854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    7.2979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    8.1229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    8.5354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    8.1229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    7.2979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    6.8854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    5.6479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 10 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 23 31  4  0  0  0  0
  8 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-952

>  <JC_XSMILES>
C1CCC2=C(C1)SC3=C2C(NCC4=CC=C5OCOC5=C4)=NC(CC6=CC=CC=C6)=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.126

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-953
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    1.8500    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1520    6.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9770    6.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699   -2.4454    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -3.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801   -2.4454    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676   -3.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051   -1.0164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  8  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 35 38  4  0  0  0  0
 27 38  4  0  0  0  0
 25 39  1  0  0  0  0
 21 39  1  0  0  0  0
 39 40  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-953

>  <JC_XSMILES>
CCCN(CC1CC1)C(=O)C2CCCN(C2)C3=CC=CC4=C3C(=O)N(CC5=CC(OC)=C(OC)C(OC)=C5)C4=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.125

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.054545455

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-959
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8653    0.4014    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6499    0.6563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2630    0.1043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0476    0.3592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2191    1.1662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6060    1.7182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8214    1.4633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8871   -5.0906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 11 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  4  0  0  0  0
 25 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-959

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2C=C(N=C2SCC(=O)NC3=CC=CC=C3)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.18

>  <W2 Pf proliferation inhibition EC50 uM>
>11.18

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-960
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    2.7845   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.6021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -3.0146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -3.8396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -3.0146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.3646    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    3.5854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5852    4.4059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3922    4.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8047    3.8630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2527    3.2499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 19 23  4  0  0  0  0
 23 24  2  0  0  0  0
 23 25  4  0  0  0  0
 16 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 28 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-960

>  <JC_XSMILES>
COC(=O)C1=CC=CC=C1NC(=O)CSC2=NC3=C(SC=C3)C(=O)N2CCN4CCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.18

>  <W2 Pf proliferation inhibition EC50 uM>
>11.18

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-962
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
   -8.6945   -1.0164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.6945    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4570   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2195    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9820   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9820    1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3320    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0945    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3320   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2695    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0395   -1.0396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5082    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0395    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2195   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0445   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 21 25  1  0  0  0  0
 23 26  1  0  0  0  0
 20 26  1  0  0  0  0
 26 27  1  0  0  0  0
 17 27  1  0  0  0  0
 27 28  2  0  0  0  0
  7 29  4  0  0  0  0
 29 30  4  0  0  0  0
  4 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-962

>  <JC_XSMILES>
OC(=O)C1=CC=C(NC(=O)C2=CC=C(C=C2)N3C(=O)C4C5CC(C=C5)C4C3=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.18

>  <W2 Pf proliferation inhibition EC50 uM>
>11.18

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-963
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
  5 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-963

>  <JC_XSMILES>
CC1=CC=C(CC(=O)NC2=CC=C(I)C=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.18

>  <W2 Pf proliferation inhibition EC50 uM>
>11.18

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-965
  Mrv1591402191617072D          

 55 62  0  0  0  0            999 V2000
   -6.7798    1.8589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7798    1.0339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4943    0.6214    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0654    0.6214    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0654   -0.2036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3509   -0.6161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3509   -1.4411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0654   -1.8536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7798   -1.4411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7798   -0.6161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0654   -2.6786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3979   -3.1635    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6529   -3.9481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4779   -3.9481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7328   -3.1635    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9628   -4.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6272   -5.3693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1121   -6.0367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9326   -5.9505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2682   -5.1968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7833   -4.5293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1679   -4.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3475   -4.5293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8625   -5.1968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1981   -5.9505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7132   -6.6179    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0487   -7.3716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5638   -8.0390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8994   -8.7927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7198   -8.8789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2048   -8.2115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8692   -7.4578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0554   -9.6326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6429  -10.3471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1949  -10.9602    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9486  -10.6246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8624   -9.8041    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6631  -11.0371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6631  -11.8621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3776  -12.2746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0920  -11.8621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8065  -12.2746    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8065  -13.0996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0920  -13.5121    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.5210  -13.5121    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0920  -11.0371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3776  -10.6246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8224  -10.4333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3375   -9.7659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5170   -9.8521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1815  -10.6058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6664  -11.2732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4869  -11.1870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0186   -6.0367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5035   -5.3693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 13 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 30 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 33 37  4  0  0  0  0
 36 38  1  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  1  0  0  0  0
 42 43  1  0  0  0  0
 43 44  1  0  0  0  0
 43 45  2  0  0  0  0
 41 46  4  0  0  0  0
 46 47  4  0  0  0  0
 38 47  4  0  0  0  0
 34 48  1  0  0  0  0
 48 49  4  0  0  0  0
 49 50  4  0  0  0  0
 50 51  4  0  0  0  0
 51 52  4  0  0  0  0
 52 53  4  0  0  0  0
 48 53  4  0  0  0  0
 25 54  4  0  0  0  0
 54 55  4  0  0  0  0
 22 55  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  37
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-965

>  <JC_XSMILES>
CC(=O)NC1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=CC=C3)C4=CC=C(OC5=CC=C(C=C5)C6=C(N=C(N6)C7=CC=C(NC(C)=O)C=C7)C8=CC=CC=C8)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
6.95

>  <W2 Pf proliferation inhibition EC50 uM>
5.59

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
50.07

>  <Powder data?>
Yes

>  <IFI value>
0.015384615

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-966
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  6  5  1  4  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 11 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
  5 28  4  0  0  0  0
 28 29  4  0  0  0  0
  2 29  4  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-966

>  <JC_XSMILES>
OC1=CC=C(C=NNC(=O)\C(NC(=O)C2=CC=CC=C2)=C\C3=CC=CC=C3)C=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.114

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-969
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    0.7145   -6.1875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-969

>  <JC_XSMILES>
FC1=CC=CC(=C1)C(=O)NNC(=O)C(=O)N2CCOCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.112

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-974
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    4.3586    7.1878    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1036    6.4032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2967    6.2317    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6557    5.7901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4007    5.0055    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9528    4.3924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7732    4.4787    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1088    3.7250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  6 14  4  0  0  0  0
  9 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-974

>  <JC_XSMILES>
NC(=O)CSC1=NN=C2C=CC(=NN12)C3=CC=C4OCOC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.106

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-975
  Mrv1591402191617072D          

 36 38  0  0  0  0            999 V2000
   -0.5230   -5.4730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -5.4730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5230   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895   -7.6164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -8.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145   -7.6164    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -8.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2520   -8.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6645   -7.6164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4895   -7.6164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9020   -8.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4895   -9.0454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9020   -9.7599    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7270   -9.7599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1395  -10.4743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9645  -10.4743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3770  -11.1888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9645  -11.9033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1395  -11.9033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7270  -11.1888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6645   -9.0454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2520   -6.9020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6645   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4895   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9020   -5.4730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7270   -5.4730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1395   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7270   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9020   -6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 17 26  4  0  0  0  0
 13 26  4  0  0  0  0
 11 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-975

>  <JC_XSMILES>
CCN(CC)CCCC(C)N(CC1=CC=CC(OCC2=CC=CC=C2)=C1)C(=O)NCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.105

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.02

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-981
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -10.7250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -9.5980    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559  -11.0270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
  6 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
M  CHG  4   1  -1   2   1  10   1  11  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-981

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(=CC(=C1)[N+]([O-])=O)C(=O)N2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.18

>  <W2 Pf proliferation inhibition EC50 uM>
1.101

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.050420168

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-984
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -0.9851   -6.1818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400   -5.3972    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0247   -5.1422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0247   -4.3172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400   -4.0623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7551   -4.7297    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6921   -3.8323    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.6059   -3.0118    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.4458   -4.1679    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
 10  9  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 15 20  4  0  0  0  0
  4 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
M  CHG  2  21   1  22  -1
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-984

>  <JC_XSMILES>
CN1C=C(C(=N1)C(=O)NN=CC2=CNC3=CC=CC=C23)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.944

>  <W2 Pf proliferation inhibition EC50 uM>
1.098

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.067669173

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-987
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  7  6  1  4  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  4  0  0  0  0
  3 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-987

>  <JC_XSMILES>
COC1=CC=C(C=NNC2=NC(O)=CC(=N2)C3=CC=CC=C3)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.632

>  <W2 Pf proliferation inhibition EC50 uM>
>1.098

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-989
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    3.3523    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    5.6479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
 17 18  2  0  0  0  0
  6 19  4  0  0  0  0
 19 20  4  0  0  0  0
  3 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-989

>  <JC_XSMILES>
COC1=CC=C(Cn2c(=S)[nH]c3ccsc3c2=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.427

>  <W2 Pf proliferation inhibition EC50 uM>
1.096

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.022988506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-998
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    4.2868    0.5786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.2464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9543   -0.7313    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -1.5160    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -1.5160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6194   -0.7313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3894   -2.1834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7250   -2.9371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2400   -3.6045    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4196   -3.5183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0840   -2.7646    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5689   -2.0972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2334   -1.3435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4129   -1.2573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0773   -0.5036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5622    0.1639    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3827    0.0776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7183   -0.6761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2267    0.9175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7116    1.5850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3761    2.3386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8610    3.0061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6815    2.9198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0170    2.1662    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5321    1.4987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9346   -4.1857    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1896   -4.9703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5221   -5.4553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8547   -4.9703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1096   -4.1857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 10 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 26 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-998

>  <JC_XSMILES>
CC1=NOC(=C1)C2=CN=C(N=C2C3CCN(CC3)CC4=CC=CN=C4)N5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1904

>  <W2 Pf proliferation inhibition EC50 uM>
>1.088

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-999
  Mrv1591402191617072D          

 40 42  0  0  0  0            999 V2000
   -4.7651   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2251   -2.0171    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4149   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8748   -1.5493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5246   -1.0816    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444   -2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261    0.3216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362    0.1657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763    0.7893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6864    0.6334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9565   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7666   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3067    0.3216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6864   -1.5493    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4966   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -1.7052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2866   -3.6903    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8457   -3.1502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -4.1998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7946   -2.4848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9845   -2.6407    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2546   -4.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647   -3.8880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3347   -3.1084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1449   -2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 14 23  4  0  0  0  0
 12 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 30 33  1  0  0  0  0
  5 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 39 40  4  0  0  0  0
  3 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-999

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=C(OC)C(OC)=C2)C(=O)CC(C)CC(C)(C)C)=C3N=CC=CC3=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.037

>  <W2 Pf proliferation inhibition EC50 uM>
0.64

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.89

>  <Powder data?>
No

>  <IFI value>
0.036363636

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1065
  Mrv1591402191617072D          

 41 44  0  0  0  0            999 V2000
    0.6538   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4856   -2.8806    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -3.4326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -4.2576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -4.6701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -4.2576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2422   -4.6701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2422   -5.4951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -3.4326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -3.0201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6417   -2.2131    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1937   -1.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9388   -0.8154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1318   -0.6439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8769    0.1407    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0922   -0.1142    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6615    0.3957    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6219    0.9254    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7921    2.0533    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8136    2.6888    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1566    1.0748    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  4  0  0  0  0
 13 14  4  0  0  0  0
  7 14  4  0  0  0  0
 14 15  1  0  0  0  0
  5 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  2  0  0  0  0
  3 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  2  0  0  0  0
 29 32  2  0  0  0  0
 25 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 35 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 33 40  4  0  0  0  0
 40 41  4  0  0  0  0
 24 41  4  0  0  0  0
M  CHG  1  25   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1065

>  <JC_XSMILES>
CCC(\C=C1/SC2=CC=C(OC)C=C2N1CCCS(O)(=O)=O)=C/C3=[N+](CCCS(O)(=O)=O)C4=CC(OC)=CC=C4S3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.473

>  <W2 Pf proliferation inhibition EC50 uM>
1.04

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.05

>  <Powder data?>
Yes

>  <IFI value>
0.227272727

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1667
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 15 21  1  0  0  0  0
  7 22  4  0  0  0  0
  3 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1667

>  <JC_XSMILES>
COC1=CC=CC(CN2CCN(CC2)C3CCCC(C)C3)=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>6.7

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2042
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2042

>  <JC_XSMILES>
COC1=CC=CC=C1C(=O)N2CCN(CC2)CC3=CC=C4C=CC=CC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.86

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023255814

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2336
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    5.1717   -0.1894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1717   -1.0144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4572   -1.4269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4572   -2.2519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1717   -2.6644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1717   -3.4894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4572   -3.9019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7427   -3.4894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7427   -2.6644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0283   -2.2519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3138   -2.6644    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3138   -3.4894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5993   -3.9019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8848   -3.4894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8848   -2.6644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5993   -2.2519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1704   -2.2519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5441   -2.6644    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1704   -1.4269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5729   -1.0690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7565   -0.2646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2421    0.3804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5829    0.3804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0973   -0.2646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9137   -1.0690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 19 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2336

>  <JC_XSMILES>
CCOC1=CC=CC=C1CN2CCCC(C2)C(=O)N3CCCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
4.4

>  <W2 Pf proliferation inhibition EC50 uM>
1.416

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
37.35

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2819
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599    0.5230    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9849    1.9520    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2819

>  <JC_XSMILES>
FC1=CC=CC=C1C(=O)N2CCN(CC2)CC3=CC=CC=C3C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.511

>  <W2 Pf proliferation inhibition EC50 uM>
2.472

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011764706

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5483
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.9500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    4.5375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   12.8605    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 23 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  CHG  2  12   1  23   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5483

>  <JC_XSMILES>
CC1=CC(N)=C2C=CC=CC2=[N+]1CCCCCCCCCC[N+]3=C(C)C=C(N)C4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0614

>  <W2 Pf proliferation inhibition EC50 uM>
0.0197

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
30.99

>  <Powder data?>
Yes

>  <IFI value>
0.057894737

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
